|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:VTA1-AIG1 (FusionGDB2 ID:97899) |
Fusion Gene Summary for VTA1-AIG1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VTA1-AIG1 | Fusion gene ID: 97899 | Hgene | Tgene | Gene symbol | VTA1 | AIG1 | Gene ID | 51534 | 51390 |
| Gene name | vesicle trafficking 1 | androgen induced 1 | |
| Synonyms | C6orf55|DRG-1|DRG1|HSPC228|LIP5|My012|SBP1 | AIG-1|dJ95L4.1 | |
| Cytomap | 6q24.1-q24.2 | 6q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vacuolar protein sorting-associated protein VTA1 homologLYST-interacting protein 5SKD1-binding protein 1Vps20-associated 1 homologdopamine-responsive gene 1 proteinhomolog of mouse SKD1-binding protein 1vesicle (multivesicular body) trafficking 1 | androgen-induced gene 1 proteinFAHFA hydrolase AIG1fatty acid esters of hydroxy fatty acids hydrolase AIG1 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q9NVV5 | |
| Ensembl transtripts involved in fusion gene | ENST00000367630, ENST00000367621, ENST00000452973, ENST00000491881, | ENST00000357847, ENST00000344492, ENST00000275235, ENST00000367598, ENST00000494282, ENST00000367596, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 16 X 12 X 9=1728 |
| # samples | 4 | 17 | |
| ** MAII score | log2(4/80*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(17/1728*10)=-3.34549656602577 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: VTA1 [Title/Abstract] AND AIG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | VTA1(142468536)-AIG1(143605247), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | VTA1-AIG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across VTA1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across AIG1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-CD-8525-01A | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
Top |
Fusion Gene ORF analysis for VTA1-AIG1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000367630 | ENST00000357847 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| Frame-shift | ENST00000367630 | ENST00000344492 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| Frame-shift | ENST00000367630 | ENST00000275235 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| 5CDS-intron | ENST00000367630 | ENST00000367598 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| 5CDS-intron | ENST00000367630 | ENST00000494282 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| 5CDS-intron | ENST00000367630 | ENST00000367596 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| In-frame | ENST00000367621 | ENST00000357847 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| In-frame | ENST00000367621 | ENST00000344492 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| In-frame | ENST00000367621 | ENST00000275235 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| 5CDS-intron | ENST00000367621 | ENST00000367598 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| 5CDS-intron | ENST00000367621 | ENST00000494282 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| 5CDS-intron | ENST00000367621 | ENST00000367596 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| In-frame | ENST00000452973 | ENST00000357847 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| In-frame | ENST00000452973 | ENST00000344492 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| In-frame | ENST00000452973 | ENST00000275235 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| 5CDS-intron | ENST00000452973 | ENST00000367598 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| 5CDS-intron | ENST00000452973 | ENST00000494282 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| 5CDS-intron | ENST00000452973 | ENST00000367596 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| intron-3CDS | ENST00000491881 | ENST00000357847 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| intron-3CDS | ENST00000491881 | ENST00000344492 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| intron-3CDS | ENST00000491881 | ENST00000275235 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| intron-intron | ENST00000491881 | ENST00000367598 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| intron-intron | ENST00000491881 | ENST00000494282 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| intron-intron | ENST00000491881 | ENST00000367596 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000367621 | VTA1 | chr6 | 142468536 | + | ENST00000357847 | AIG1 | chr6 | 143605247 | + | 1089 | 143 | 31 | 450 | 139 |
| ENST00000367621 | VTA1 | chr6 | 142468536 | + | ENST00000344492 | AIG1 | chr6 | 143605247 | + | 1089 | 143 | 31 | 450 | 139 |
| ENST00000367621 | VTA1 | chr6 | 142468536 | + | ENST00000275235 | AIG1 | chr6 | 143605247 | + | 921 | 143 | 31 | 453 | 140 |
| ENST00000452973 | VTA1 | chr6 | 142468536 | + | ENST00000357847 | AIG1 | chr6 | 143605247 | + | 1085 | 139 | 27 | 446 | 139 |
| ENST00000452973 | VTA1 | chr6 | 142468536 | + | ENST00000344492 | AIG1 | chr6 | 143605247 | + | 1085 | 139 | 27 | 446 | 139 |
| ENST00000452973 | VTA1 | chr6 | 142468536 | + | ENST00000275235 | AIG1 | chr6 | 143605247 | + | 917 | 139 | 27 | 449 | 140 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000367621 | ENST00000357847 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + | 0.06739697 | 0.93260306 |
| ENST00000367621 | ENST00000344492 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + | 0.06739697 | 0.93260306 |
| ENST00000367621 | ENST00000275235 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + | 0.021845918 | 0.97815406 |
| ENST00000452973 | ENST00000357847 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + | 0.06432543 | 0.9356746 |
| ENST00000452973 | ENST00000344492 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + | 0.06432543 | 0.9356746 |
| ENST00000452973 | ENST00000275235 | VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605247 | + | 0.019472806 | 0.98052716 |
Top |
Fusion Genomic Features for VTA1-AIG1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605246 | + | 0.005868156 | 0.99413186 |
| VTA1 | chr6 | 142468536 | + | AIG1 | chr6 | 143605246 | + | 0.005868156 | 0.99413186 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for VTA1-AIG1 |
| Go to FGviewer for the breakpoints of chr6:142468536-chr6:143605247 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | AIG1 |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888). {ECO:0000269|PubMed:27018888}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000275235 | 2 | 7 | 145_156 | 133.0 | 246.0 | Topological domain | Cytoplasmic | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000275235 | 2 | 7 | 180_193 | 133.0 | 246.0 | Topological domain | Extracellular | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000275235 | 2 | 7 | 217_238 | 133.0 | 246.0 | Topological domain | Cytoplasmic | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000344492 | 1 | 5 | 111_124 | 81.0 | 187.0 | Topological domain | Extracellular | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000344492 | 1 | 5 | 145_156 | 81.0 | 187.0 | Topological domain | Cytoplasmic | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000344492 | 1 | 5 | 180_193 | 81.0 | 187.0 | Topological domain | Extracellular | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000344492 | 1 | 5 | 217_238 | 81.0 | 187.0 | Topological domain | Cytoplasmic | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000357847 | 2 | 6 | 145_156 | 133.0 | 239.0 | Topological domain | Cytoplasmic | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000357847 | 2 | 6 | 180_193 | 133.0 | 239.0 | Topological domain | Extracellular | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000357847 | 2 | 6 | 217_238 | 133.0 | 239.0 | Topological domain | Cytoplasmic | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000494282 | 0 | 4 | 111_124 | 0 | 138.0 | Topological domain | Extracellular | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000494282 | 0 | 4 | 145_156 | 0 | 138.0 | Topological domain | Cytoplasmic | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000494282 | 0 | 4 | 180_193 | 0 | 138.0 | Topological domain | Extracellular | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000494282 | 0 | 4 | 1_12 | 0 | 138.0 | Topological domain | Cytoplasmic | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000494282 | 0 | 4 | 217_238 | 0 | 138.0 | Topological domain | Cytoplasmic | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000494282 | 0 | 4 | 31_44 | 0 | 138.0 | Topological domain | Extracellular | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000494282 | 0 | 4 | 68_87 | 0 | 138.0 | Topological domain | Cytoplasmic | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000275235 | 2 | 7 | 157_179 | 133.0 | 246.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000275235 | 2 | 7 | 194_216 | 133.0 | 246.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000344492 | 1 | 5 | 125_144 | 81.0 | 187.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000344492 | 1 | 5 | 157_179 | 81.0 | 187.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000344492 | 1 | 5 | 194_216 | 81.0 | 187.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000344492 | 1 | 5 | 88_110 | 81.0 | 187.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000357847 | 2 | 6 | 157_179 | 133.0 | 239.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000357847 | 2 | 6 | 194_216 | 133.0 | 239.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000494282 | 0 | 4 | 125_144 | 0 | 138.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000494282 | 0 | 4 | 13_30 | 0 | 138.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000494282 | 0 | 4 | 157_179 | 0 | 138.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000494282 | 0 | 4 | 194_216 | 0 | 138.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000494282 | 0 | 4 | 45_67 | 0 | 138.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000494282 | 0 | 4 | 88_110 | 0 | 138.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000275235 | 2 | 7 | 111_124 | 133.0 | 246.0 | Topological domain | Extracellular | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000275235 | 2 | 7 | 1_12 | 133.0 | 246.0 | Topological domain | Cytoplasmic | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000275235 | 2 | 7 | 31_44 | 133.0 | 246.0 | Topological domain | Extracellular | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000275235 | 2 | 7 | 68_87 | 133.0 | 246.0 | Topological domain | Cytoplasmic | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000344492 | 1 | 5 | 1_12 | 81.0 | 187.0 | Topological domain | Cytoplasmic | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000344492 | 1 | 5 | 31_44 | 81.0 | 187.0 | Topological domain | Extracellular | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000344492 | 1 | 5 | 68_87 | 81.0 | 187.0 | Topological domain | Cytoplasmic | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000357847 | 2 | 6 | 111_124 | 133.0 | 239.0 | Topological domain | Extracellular | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000357847 | 2 | 6 | 1_12 | 133.0 | 239.0 | Topological domain | Cytoplasmic | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000357847 | 2 | 6 | 31_44 | 133.0 | 239.0 | Topological domain | Extracellular | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000357847 | 2 | 6 | 68_87 | 133.0 | 239.0 | Topological domain | Cytoplasmic | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000275235 | 2 | 7 | 125_144 | 133.0 | 246.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000275235 | 2 | 7 | 13_30 | 133.0 | 246.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000275235 | 2 | 7 | 45_67 | 133.0 | 246.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000275235 | 2 | 7 | 88_110 | 133.0 | 246.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000344492 | 1 | 5 | 13_30 | 81.0 | 187.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000344492 | 1 | 5 | 45_67 | 81.0 | 187.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000357847 | 2 | 6 | 125_144 | 133.0 | 239.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000357847 | 2 | 6 | 13_30 | 133.0 | 239.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000357847 | 2 | 6 | 45_67 | 133.0 | 239.0 | Transmembrane | Helical | |
| Tgene | AIG1 | chr6:142468536 | chr6:143605247 | ENST00000357847 | 2 | 6 | 88_110 | 133.0 | 239.0 | Transmembrane | Helical |
Top |
Fusion Gene Sequence for VTA1-AIG1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000367621_ENST00000357847_TCGA-CD-8525-01A_VTA1_chr6_142468536_+_AIG1_chr6_143605247_length(transcript)=1089nt_BP=143nt GCGAGTAGGAAGTGGTGAGTTCGGAGTAGAGATGGCCGCGCTTGCACCGCTGCCCCCGCTCCCCGCACAGTTCAAGAGCATACAGCATCA TCTGAGGACGGCTCAGGAGCATGACAAGCGAGACCCTGTGGTGGCTTATTACTCACACGACGGTTCTGCCCTTTATATTAATCGAGATGA GGACATCGCACCATCAGTATCCCAGCAGGAGCAGCGGACTTACCGCCATATGTACCTTCTCTGTTGGCTATATATTATGGGTGTGCTGGG TGCATCATGTAACTGGCATGTGGGTGTACCCTTTCCTGGAACACATTGGCCCAGGAGCCAGAATCATCTTCTTTGGGTCTACAACCATCT TAATGAACTTCCTGTACCTGCTGGGAGAAGTTCTGAACAACTATATCTGGGATACACAGAAAAGTATGGAAGAAGAGAAAGAAAAGCCTA AATTGGAATGAGATCCAAGTCTAAACGCAAGAGCTAGATTGAGCCGCCATTGAAGACTCCTTCCCCTCGGGCATTGGCAGTGGGGGAGAA AAGGCTTCAAAGGAACTTGGTGGCATCAGCACCCCCCTCCCCCAATGAGGACACCTTTTATATATAAATATGTATAAACATAGAATACAG TTGTTTCCAAAAGAACTCACCCTCACTGTGTGTTAAAGAATTCTTCCCAAAGTCATTACTGATAATAACATTTTTTCCTTTTCTAGTTTT AAAACCAGAATTGGACCTTGGATTTTTATTTTGGCAATTGTAACTCCATCTAATCAAGAAAGAATAAAAGTTTATTGCACTTCTTTTTGA GAAATATGTTAAAGTCAAAGGGGCATATATAGAGTAAGGCTTTTGTGTATTTAATCCTAAAGGTGGCTGTAATCATGAACCTAGGCCACC ATGGGGACCTGAGAGGGAAGGGGACAGATGTTTCTCATTGCATAATGTCACAGTTGCCTCAAATGAGCACCATTTGTAATAATGATGTCA ATTTCATGAAAAGCCTGAGTGTATTGCATCTCTTGATTTAATCATGTGAAACTTTTCCTAGATGCAAATGCTGACTAATAAAGACAAAGC >In-frame_ENST00000367621_ENST00000357847_TCGA-CD-8525-01A_VTA1_chr6_142468536_+_AIG1_chr6_143605247_length(amino acids)=139AA_start in transcript=31_stop in transcript=450 MAALAPLPPLPAQFKSIQHHLRTAQEHDKRDPVVAYYSHDGSALYINRDEDIAPSVSQQEQRTYRHMYLLCWLYIMGVLGASCNWHVGVP -------------------------------------------------------------- >In-frame_ENST00000367621_ENST00000344492_TCGA-CD-8525-01A_VTA1_chr6_142468536_+_AIG1_chr6_143605247_length(transcript)=1089nt_BP=143nt GCGAGTAGGAAGTGGTGAGTTCGGAGTAGAGATGGCCGCGCTTGCACCGCTGCCCCCGCTCCCCGCACAGTTCAAGAGCATACAGCATCA TCTGAGGACGGCTCAGGAGCATGACAAGCGAGACCCTGTGGTGGCTTATTACTCACACGACGGTTCTGCCCTTTATATTAATCGAGATGA GGACATCGCACCATCAGTATCCCAGCAGGAGCAGCGGACTTACCGCCATATGTACCTTCTCTGTTGGCTATATATTATGGGTGTGCTGGG TGCATCATGTAACTGGCATGTGGGTGTACCCTTTCCTGGAACACATTGGCCCAGGAGCCAGAATCATCTTCTTTGGGTCTACAACCATCT TAATGAACTTCCTGTACCTGCTGGGAGAAGTTCTGAACAACTATATCTGGGATACACAGAAAAGTATGGAAGAAGAGAAAGAAAAGCCTA AATTGGAATGAGATCCAAGTCTAAACGCAAGAGCTAGATTGAGCCGCCATTGAAGACTCCTTCCCCTCGGGCATTGGCAGTGGGGGAGAA AAGGCTTCAAAGGAACTTGGTGGCATCAGCACCCCCCTCCCCCAATGAGGACACCTTTTATATATAAATATGTATAAACATAGAATACAG TTGTTTCCAAAAGAACTCACCCTCACTGTGTGTTAAAGAATTCTTCCCAAAGTCATTACTGATAATAACATTTTTTCCTTTTCTAGTTTT AAAACCAGAATTGGACCTTGGATTTTTATTTTGGCAATTGTAACTCCATCTAATCAAGAAAGAATAAAAGTTTATTGCACTTCTTTTTGA GAAATATGTTAAAGTCAAAGGGGCATATATAGAGTAAGGCTTTTGTGTATTTAATCCTAAAGGTGGCTGTAATCATGAACCTAGGCCACC ATGGGGACCTGAGAGGGAAGGGGACAGATGTTTCTCATTGCATAATGTCACAGTTGCCTCAAATGAGCACCATTTGTAATAATGATGTCA ATTTCATGAAAAGCCTGAGTGTATTGCATCTCTTGATTTAATCATGTGAAACTTTTCCTAGATGCAAATGCTGACTAATAAAGACAAAGC >In-frame_ENST00000367621_ENST00000344492_TCGA-CD-8525-01A_VTA1_chr6_142468536_+_AIG1_chr6_143605247_length(amino acids)=139AA_start in transcript=31_stop in transcript=450 MAALAPLPPLPAQFKSIQHHLRTAQEHDKRDPVVAYYSHDGSALYINRDEDIAPSVSQQEQRTYRHMYLLCWLYIMGVLGASCNWHVGVP -------------------------------------------------------------- >In-frame_ENST00000367621_ENST00000275235_TCGA-CD-8525-01A_VTA1_chr6_142468536_+_AIG1_chr6_143605247_length(transcript)=921nt_BP=143nt GCGAGTAGGAAGTGGTGAGTTCGGAGTAGAGATGGCCGCGCTTGCACCGCTGCCCCCGCTCCCCGCACAGTTCAAGAGCATACAGCATCA TCTGAGGACGGCTCAGGAGCATGACAAGCGAGACCCTGTGGTGGCTTATTACTCACACGACGGTTCTGCCCTTTATATTAATCGAGATGA GGACATCGCACCATCAGTATCCCAGCAGGAGCAGCGGACTTACCGCCATATGTACCTTCTCTGTTGGCTATATATTATGGGTGTGCTGGG TGCATCATGTAACTGGCATGTGGGTGTACCCTTTCCTGGAACACATTGGCCCAGGAGCCAGAATCATCTTCTTTGGGTCTACAACCATCT TAATGAACTTCCTGTACCTGCTGGGAGAAGTTCTGAACAACTATATCTGGGATACACAGAAAAAGCCTCCATCTTGGCAAGATATGAAAA TTAAGTTTATGTACCTAGGACCATCTAGTTAGTTCCACAAAGACAGATGTTTTGTGCCAAGTAAGTATCATCCTCATTTACAAGAGGGGT CACAAACTGCTGGCCTCCCCCAACTTCTACCTATCAAGTTCTGTTAGGCCTACATCGTGGAATTTTTGTTTTTGAATCAGTATTTTAAAA TTGGGTGATTTTGGCTGGGCGCAGTGGCTCATGCCTGTAATCCCGGCACTTTGGGAGACTGAGGCAGGTGGATCACGAGGTCAAGAGATG GAGACCATCCTGGCCAACATGGTGAAATCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGCGTGTGCCTGTAGTCCCAGG TACTCGGGAGGCTGAGGCAGGAGAACTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATCATGCCACTGCACCCCAGCCTGGC >In-frame_ENST00000367621_ENST00000275235_TCGA-CD-8525-01A_VTA1_chr6_142468536_+_AIG1_chr6_143605247_length(amino acids)=140AA_start in transcript=31_stop in transcript=453 MAALAPLPPLPAQFKSIQHHLRTAQEHDKRDPVVAYYSHDGSALYINRDEDIAPSVSQQEQRTYRHMYLLCWLYIMGVLGASCNWHVGVP -------------------------------------------------------------- >In-frame_ENST00000452973_ENST00000357847_TCGA-CD-8525-01A_VTA1_chr6_142468536_+_AIG1_chr6_143605247_length(transcript)=1085nt_BP=139nt GTAGGAAGTGGTGAGTTCGGAGTAGAGATGGCCGCGCTTGCACCGCTGCCCCCGCTCCCCGCACAGTTCAAGAGCATACAGCATCATCTG AGGACGGCTCAGGAGCATGACAAGCGAGACCCTGTGGTGGCTTATTACTCACACGACGGTTCTGCCCTTTATATTAATCGAGATGAGGAC ATCGCACCATCAGTATCCCAGCAGGAGCAGCGGACTTACCGCCATATGTACCTTCTCTGTTGGCTATATATTATGGGTGTGCTGGGTGCA TCATGTAACTGGCATGTGGGTGTACCCTTTCCTGGAACACATTGGCCCAGGAGCCAGAATCATCTTCTTTGGGTCTACAACCATCTTAAT GAACTTCCTGTACCTGCTGGGAGAAGTTCTGAACAACTATATCTGGGATACACAGAAAAGTATGGAAGAAGAGAAAGAAAAGCCTAAATT GGAATGAGATCCAAGTCTAAACGCAAGAGCTAGATTGAGCCGCCATTGAAGACTCCTTCCCCTCGGGCATTGGCAGTGGGGGAGAAAAGG CTTCAAAGGAACTTGGTGGCATCAGCACCCCCCTCCCCCAATGAGGACACCTTTTATATATAAATATGTATAAACATAGAATACAGTTGT TTCCAAAAGAACTCACCCTCACTGTGTGTTAAAGAATTCTTCCCAAAGTCATTACTGATAATAACATTTTTTCCTTTTCTAGTTTTAAAA CCAGAATTGGACCTTGGATTTTTATTTTGGCAATTGTAACTCCATCTAATCAAGAAAGAATAAAAGTTTATTGCACTTCTTTTTGAGAAA TATGTTAAAGTCAAAGGGGCATATATAGAGTAAGGCTTTTGTGTATTTAATCCTAAAGGTGGCTGTAATCATGAACCTAGGCCACCATGG GGACCTGAGAGGGAAGGGGACAGATGTTTCTCATTGCATAATGTCACAGTTGCCTCAAATGAGCACCATTTGTAATAATGATGTCAATTT CATGAAAAGCCTGAGTGTATTGCATCTCTTGATTTAATCATGTGAAACTTTTCCTAGATGCAAATGCTGACTAATAAAGACAAAGCCACC >In-frame_ENST00000452973_ENST00000357847_TCGA-CD-8525-01A_VTA1_chr6_142468536_+_AIG1_chr6_143605247_length(amino acids)=139AA_start in transcript=27_stop in transcript=446 MAALAPLPPLPAQFKSIQHHLRTAQEHDKRDPVVAYYSHDGSALYINRDEDIAPSVSQQEQRTYRHMYLLCWLYIMGVLGASCNWHVGVP -------------------------------------------------------------- >In-frame_ENST00000452973_ENST00000344492_TCGA-CD-8525-01A_VTA1_chr6_142468536_+_AIG1_chr6_143605247_length(transcript)=1085nt_BP=139nt GTAGGAAGTGGTGAGTTCGGAGTAGAGATGGCCGCGCTTGCACCGCTGCCCCCGCTCCCCGCACAGTTCAAGAGCATACAGCATCATCTG AGGACGGCTCAGGAGCATGACAAGCGAGACCCTGTGGTGGCTTATTACTCACACGACGGTTCTGCCCTTTATATTAATCGAGATGAGGAC ATCGCACCATCAGTATCCCAGCAGGAGCAGCGGACTTACCGCCATATGTACCTTCTCTGTTGGCTATATATTATGGGTGTGCTGGGTGCA TCATGTAACTGGCATGTGGGTGTACCCTTTCCTGGAACACATTGGCCCAGGAGCCAGAATCATCTTCTTTGGGTCTACAACCATCTTAAT GAACTTCCTGTACCTGCTGGGAGAAGTTCTGAACAACTATATCTGGGATACACAGAAAAGTATGGAAGAAGAGAAAGAAAAGCCTAAATT GGAATGAGATCCAAGTCTAAACGCAAGAGCTAGATTGAGCCGCCATTGAAGACTCCTTCCCCTCGGGCATTGGCAGTGGGGGAGAAAAGG CTTCAAAGGAACTTGGTGGCATCAGCACCCCCCTCCCCCAATGAGGACACCTTTTATATATAAATATGTATAAACATAGAATACAGTTGT TTCCAAAAGAACTCACCCTCACTGTGTGTTAAAGAATTCTTCCCAAAGTCATTACTGATAATAACATTTTTTCCTTTTCTAGTTTTAAAA CCAGAATTGGACCTTGGATTTTTATTTTGGCAATTGTAACTCCATCTAATCAAGAAAGAATAAAAGTTTATTGCACTTCTTTTTGAGAAA TATGTTAAAGTCAAAGGGGCATATATAGAGTAAGGCTTTTGTGTATTTAATCCTAAAGGTGGCTGTAATCATGAACCTAGGCCACCATGG GGACCTGAGAGGGAAGGGGACAGATGTTTCTCATTGCATAATGTCACAGTTGCCTCAAATGAGCACCATTTGTAATAATGATGTCAATTT CATGAAAAGCCTGAGTGTATTGCATCTCTTGATTTAATCATGTGAAACTTTTCCTAGATGCAAATGCTGACTAATAAAGACAAAGCCACC >In-frame_ENST00000452973_ENST00000344492_TCGA-CD-8525-01A_VTA1_chr6_142468536_+_AIG1_chr6_143605247_length(amino acids)=139AA_start in transcript=27_stop in transcript=446 MAALAPLPPLPAQFKSIQHHLRTAQEHDKRDPVVAYYSHDGSALYINRDEDIAPSVSQQEQRTYRHMYLLCWLYIMGVLGASCNWHVGVP -------------------------------------------------------------- >In-frame_ENST00000452973_ENST00000275235_TCGA-CD-8525-01A_VTA1_chr6_142468536_+_AIG1_chr6_143605247_length(transcript)=917nt_BP=139nt GTAGGAAGTGGTGAGTTCGGAGTAGAGATGGCCGCGCTTGCACCGCTGCCCCCGCTCCCCGCACAGTTCAAGAGCATACAGCATCATCTG AGGACGGCTCAGGAGCATGACAAGCGAGACCCTGTGGTGGCTTATTACTCACACGACGGTTCTGCCCTTTATATTAATCGAGATGAGGAC ATCGCACCATCAGTATCCCAGCAGGAGCAGCGGACTTACCGCCATATGTACCTTCTCTGTTGGCTATATATTATGGGTGTGCTGGGTGCA TCATGTAACTGGCATGTGGGTGTACCCTTTCCTGGAACACATTGGCCCAGGAGCCAGAATCATCTTCTTTGGGTCTACAACCATCTTAAT GAACTTCCTGTACCTGCTGGGAGAAGTTCTGAACAACTATATCTGGGATACACAGAAAAAGCCTCCATCTTGGCAAGATATGAAAATTAA GTTTATGTACCTAGGACCATCTAGTTAGTTCCACAAAGACAGATGTTTTGTGCCAAGTAAGTATCATCCTCATTTACAAGAGGGGTCACA AACTGCTGGCCTCCCCCAACTTCTACCTATCAAGTTCTGTTAGGCCTACATCGTGGAATTTTTGTTTTTGAATCAGTATTTTAAAATTGG GTGATTTTGGCTGGGCGCAGTGGCTCATGCCTGTAATCCCGGCACTTTGGGAGACTGAGGCAGGTGGATCACGAGGTCAAGAGATGGAGA CCATCCTGGCCAACATGGTGAAATCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGCGTGTGCCTGTAGTCCCAGGTACT CGGGAGGCTGAGGCAGGAGAACTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATCATGCCACTGCACCCCAGCCTGGCAACA >In-frame_ENST00000452973_ENST00000275235_TCGA-CD-8525-01A_VTA1_chr6_142468536_+_AIG1_chr6_143605247_length(amino acids)=140AA_start in transcript=27_stop in transcript=449 MAALAPLPPLPAQFKSIQHHLRTAQEHDKRDPVVAYYSHDGSALYINRDEDIAPSVSQQEQRTYRHMYLLCWLYIMGVLGASCNWHVGVP -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for VTA1-AIG1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | VTA1 | chr6:142468536 | chr6:143605247 | ENST00000367630 | + | 1 | 8 | 2_75 | 37.333333333333336 | 308.0 | CHMP5 |
| Hgene | VTA1 | chr6:142468536 | chr6:143605247 | ENST00000367630 | + | 1 | 8 | 2_186 | 37.333333333333336 | 308.0 | IST1 |
| Hgene | VTA1 | chr6:142468536 | chr6:143605247 | ENST00000367630 | + | 1 | 8 | 198_307 | 37.333333333333336 | 308.0 | VPS4B |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for VTA1-AIG1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for VTA1-AIG1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies