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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WDHD1-LGALS3 (FusionGDB2 ID:98185)

Fusion Gene Summary for WDHD1-LGALS3

check button Fusion gene summary
Fusion gene informationFusion gene name: WDHD1-LGALS3
Fusion gene ID: 98185
HgeneTgene
Gene symbol

WDHD1

LGALS3

Gene ID

11169

3958

Gene nameWD repeat and HMG-box DNA binding protein 1galectin 3
SynonymsAND-1|AND1|CHTF4|CTF4CBP35|GAL3|GALBP|GALIG|L31|LGALS2|MAC2
Cytomap

14q22.2-q22.3

14q22.3

Type of geneprotein-codingprotein-coding
DescriptionWD repeat and HMG-box DNA-binding protein 1Acidic nucleoplasmic DNA-binding protein 1CTF4, chromosome transmission fidelity factor 4 homologgalectin-335 kDa lectinIgE-binding proteinMAC-2 antigenadvanced glycation end-product receptor 3carbohydrate-binding protein 35epididymis secretory sperm binding proteingalactose-specific lectin 3laminin-binding proteinlectin L-29lectin, galacto
Modification date2020031320200322
UniProtAcc.

Q08380

Ensembl transtripts involved in fusion geneENST00000360586, ENST00000420358, 
ENST00000359167, ENST00000421192, 
ENST00000254301, ENST00000553755, 
ENST00000554715, 
Fusion gene scores* DoF score7 X 9 X 8=5046 X 9 X 4=216
# samples 1211
** MAII scorelog2(12/504*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/216*10)=-0.973527788638809
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDHD1 [Title/Abstract] AND LGALS3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWDHD1(55493429)-LGALS3(55606993), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLGALS3

GO:0002548

monocyte chemotaxis

10925302

TgeneLGALS3

GO:0030593

neutrophil chemotaxis

10925302

TgeneLGALS3

GO:0031334

positive regulation of protein complex assembly

24846175

TgeneLGALS3

GO:0045806

negative regulation of endocytosis

19706535

TgeneLGALS3

GO:0048245

eosinophil chemotaxis

10925302

TgeneLGALS3

GO:0048246

macrophage chemotaxis

10925302

TgeneLGALS3

GO:0050918

positive chemotaxis

10925302

TgeneLGALS3

GO:0070232

regulation of T cell apoptotic process

8692888

TgeneLGALS3

GO:0071674

mononuclear cell migration

10925302

TgeneLGALS3

GO:0071677

positive regulation of mononuclear cell migration

10925302

TgeneLGALS3

GO:0090280

positive regulation of calcium ion import

10925302

TgeneLGALS3

GO:1903078

positive regulation of protein localization to plasma membrane

24846175

TgeneLGALS3

GO:2001200

positive regulation of dendritic cell differentiation

16116184

TgeneLGALS3

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

22761016


check buttonFusion gene breakpoints across WDHD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LGALS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1464-01AWDHD1chr14

55493429

-LGALS3chr14

55606993

+
ChimerDB4OVTCGA-24-1464WDHD1chr14

55493428

-LGALS3chr14

55606992

+
ChimerDB4OVTCGA-24-1464-01AWDHD1chr14

55493429

-LGALS3chr14

55606993

+
ChimerDB4OVTCGA-24-1464-01AWDHD1chr14

55493746

-LGALS3chr14

55606993

+


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Fusion Gene ORF analysis for WDHD1-LGALS3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000360586ENST00000254301WDHD1chr14

55493429

-LGALS3chr14

55606993

+
5CDS-3UTRENST00000360586ENST00000553755WDHD1chr14

55493429

-LGALS3chr14

55606993

+
5CDS-3UTRENST00000360586ENST00000554715WDHD1chr14

55493429

-LGALS3chr14

55606993

+
intron-3CDSENST00000420358ENST00000254301WDHD1chr14

55493429

-LGALS3chr14

55606993

+
intron-3UTRENST00000420358ENST00000553755WDHD1chr14

55493429

-LGALS3chr14

55606993

+
intron-3UTRENST00000420358ENST00000554715WDHD1chr14

55493429

-LGALS3chr14

55606993

+
intron-3CDSENST00000359167ENST00000254301WDHD1chr14

55493429

-LGALS3chr14

55606993

+
intron-3UTRENST00000359167ENST00000553755WDHD1chr14

55493429

-LGALS3chr14

55606993

+
intron-3UTRENST00000359167ENST00000554715WDHD1chr14

55493429

-LGALS3chr14

55606993

+
5UTR-3CDSENST00000421192ENST00000254301WDHD1chr14

55493429

-LGALS3chr14

55606993

+
5UTR-3UTRENST00000421192ENST00000553755WDHD1chr14

55493429

-LGALS3chr14

55606993

+
5UTR-3UTRENST00000421192ENST00000554715WDHD1chr14

55493429

-LGALS3chr14

55606993

+
In-frameENST00000360586ENST00000254301WDHD1chr14

55493428

-LGALS3chr14

55606992

+
5CDS-3UTRENST00000360586ENST00000553755WDHD1chr14

55493428

-LGALS3chr14

55606992

+
5CDS-3UTRENST00000360586ENST00000554715WDHD1chr14

55493428

-LGALS3chr14

55606992

+
intron-3CDSENST00000420358ENST00000254301WDHD1chr14

55493428

-LGALS3chr14

55606992

+
intron-3UTRENST00000420358ENST00000553755WDHD1chr14

55493428

-LGALS3chr14

55606992

+
intron-3UTRENST00000420358ENST00000554715WDHD1chr14

55493428

-LGALS3chr14

55606992

+
intron-3CDSENST00000359167ENST00000254301WDHD1chr14

55493428

-LGALS3chr14

55606992

+
intron-3UTRENST00000359167ENST00000553755WDHD1chr14

55493428

-LGALS3chr14

55606992

+
intron-3UTRENST00000359167ENST00000554715WDHD1chr14

55493428

-LGALS3chr14

55606992

+
5UTR-3CDSENST00000421192ENST00000254301WDHD1chr14

55493428

-LGALS3chr14

55606992

+
5UTR-3UTRENST00000421192ENST00000553755WDHD1chr14

55493428

-LGALS3chr14

55606992

+
5UTR-3UTRENST00000421192ENST00000554715WDHD1chr14

55493428

-LGALS3chr14

55606992

+
5UTR-3CDSENST00000360586ENST00000254301WDHD1chr14

55493746

-LGALS3chr14

55606993

+
5UTR-3UTRENST00000360586ENST00000553755WDHD1chr14

55493746

-LGALS3chr14

55606993

+
5UTR-3UTRENST00000360586ENST00000554715WDHD1chr14

55493746

-LGALS3chr14

55606993

+
5UTR-3CDSENST00000420358ENST00000254301WDHD1chr14

55493746

-LGALS3chr14

55606993

+
5UTR-3UTRENST00000420358ENST00000553755WDHD1chr14

55493746

-LGALS3chr14

55606993

+
5UTR-3UTRENST00000420358ENST00000554715WDHD1chr14

55493746

-LGALS3chr14

55606993

+
intron-3CDSENST00000359167ENST00000254301WDHD1chr14

55493746

-LGALS3chr14

55606993

+
intron-3UTRENST00000359167ENST00000553755WDHD1chr14

55493746

-LGALS3chr14

55606993

+
intron-3UTRENST00000359167ENST00000554715WDHD1chr14

55493746

-LGALS3chr14

55606993

+
5UTR-3CDSENST00000421192ENST00000254301WDHD1chr14

55493746

-LGALS3chr14

55606993

+
5UTR-3UTRENST00000421192ENST00000553755WDHD1chr14

55493746

-LGALS3chr14

55606993

+
5UTR-3UTRENST00000421192ENST00000554715WDHD1chr14

55493746

-LGALS3chr14

55606993

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360586WDHD1chr1455493429-ENST00000254301LGALS3chr1455606993+686143158553131
ENST00000360586WDHD1chr1455493428-ENST00000254301LGALS3chr1455606992+686143158553131

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360586ENST00000254301WDHD1chr1455493429-LGALS3chr1455606993+0.0163934340.9836066
ENST00000360586ENST00000254301WDHD1chr1455493428-LGALS3chr1455606992+0.0163934340.9836066

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Fusion Genomic Features for WDHD1-LGALS3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
WDHD1chr1455493428-LGALS3chr1455606992+0.083189140.9168108
WDHD1chr1455493428-LGALS3chr1455606992+0.083189140.9168108
WDHD1chr1455493745-LGALS3chr1455606992+0.0276992580.9723007
WDHD1chr1455493428-LGALS3chr1455606992+0.083189140.9168108
WDHD1chr1455493428-LGALS3chr1455606992+0.083189140.9168108
WDHD1chr1455493745-LGALS3chr1455606992+0.0276992580.9723007

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for WDHD1-LGALS3


check button Go to

FGviewer for the breakpoints of chr14:55493429-chr14:55606993

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LGALS3

Q08380

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells. {ECO:0000269|PubMed:11146440, ECO:0000269|PubMed:8034587, ECO:0000269|PubMed:9501082}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLGALS3chr14:55493428chr14:55606992ENST0000025430126118_248114.0251.0DomainGalectin
TgeneLGALS3chr14:55493429chr14:55606993ENST0000025430126118_248114.0251.0DomainGalectin
TgeneLGALS3chr14:55493428chr14:55606992ENST0000025430126226_241114.0251.0MotifNuclear export signal
TgeneLGALS3chr14:55493429chr14:55606993ENST0000025430126226_241114.0251.0MotifNuclear export signal
TgeneLGALS3chr14:55493428chr14:55606992ENST0000025430126181_187114.0251.0RegionBeta-galactoside binding
TgeneLGALS3chr14:55493429chr14:55606993ENST0000025430126181_187114.0251.0RegionBeta-galactoside binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDHD1chr14:55493428chr14:55606992ENST00000360586-226829_83625.6666666666666681130.0Compositional biasNote=Glu-rich (acidic)
HgeneWDHD1chr14:55493428chr14:55606992ENST00000360586-226862_87825.6666666666666681130.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneWDHD1chr14:55493429chr14:55606993ENST00000360586-226829_83625.6666666666666681130.0Compositional biasNote=Glu-rich (acidic)
HgeneWDHD1chr14:55493429chr14:55606993ENST00000360586-226862_87825.6666666666666681130.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneWDHD1chr14:55493428chr14:55606992ENST00000360586-2261016_107925.6666666666666681130.0DNA bindingHMG box
HgeneWDHD1chr14:55493429chr14:55606993ENST00000360586-2261016_107925.6666666666666681130.0DNA bindingHMG box
HgeneWDHD1chr14:55493428chr14:55606992ENST00000360586-22611_5025.6666666666666681130.0RepeatNote=WD 1
HgeneWDHD1chr14:55493428chr14:55606992ENST00000360586-226134_17325.6666666666666681130.0RepeatNote=WD 4
HgeneWDHD1chr14:55493428chr14:55606992ENST00000360586-226184_22325.6666666666666681130.0RepeatNote=WD 5
HgeneWDHD1chr14:55493428chr14:55606992ENST00000360586-226228_26725.6666666666666681130.0RepeatNote=WD 6
HgeneWDHD1chr14:55493428chr14:55606992ENST00000360586-226271_31025.6666666666666681130.0RepeatNote=WD 7
HgeneWDHD1chr14:55493428chr14:55606992ENST00000360586-22652_9125.6666666666666681130.0RepeatNote=WD 2
HgeneWDHD1chr14:55493428chr14:55606992ENST00000360586-22692_13125.6666666666666681130.0RepeatNote=WD 3
HgeneWDHD1chr14:55493429chr14:55606993ENST00000360586-22611_5025.6666666666666681130.0RepeatNote=WD 1
HgeneWDHD1chr14:55493429chr14:55606993ENST00000360586-226134_17325.6666666666666681130.0RepeatNote=WD 4
HgeneWDHD1chr14:55493429chr14:55606993ENST00000360586-226184_22325.6666666666666681130.0RepeatNote=WD 5
HgeneWDHD1chr14:55493429chr14:55606993ENST00000360586-226228_26725.6666666666666681130.0RepeatNote=WD 6
HgeneWDHD1chr14:55493429chr14:55606993ENST00000360586-226271_31025.6666666666666681130.0RepeatNote=WD 7
HgeneWDHD1chr14:55493429chr14:55606993ENST00000360586-22652_9125.6666666666666681130.0RepeatNote=WD 2
HgeneWDHD1chr14:55493429chr14:55606993ENST00000360586-22692_13125.6666666666666681130.0RepeatNote=WD 3
TgeneLGALS3chr14:55493428chr14:55606992ENST000002543012636_109114.0251.0RegionNote=8 X 9 AA tandem repeats of Y-P-G-X(3)-P-G-A
TgeneLGALS3chr14:55493429chr14:55606993ENST000002543012636_109114.0251.0RegionNote=8 X 9 AA tandem repeats of Y-P-G-X(3)-P-G-A
TgeneLGALS3chr14:55493428chr14:55606992ENST0000025430126101_109114.0251.0RepeatNote=8%3B approximate
TgeneLGALS3chr14:55493428chr14:55606992ENST000002543012636_44114.0251.0RepeatNote=1
TgeneLGALS3chr14:55493428chr14:55606992ENST000002543012645_53114.0251.0RepeatNote=2
TgeneLGALS3chr14:55493428chr14:55606992ENST000002543012654_62114.0251.0RepeatNote=3
TgeneLGALS3chr14:55493428chr14:55606992ENST000002543012663_69114.0251.0RepeatNote=4%3B approximate
TgeneLGALS3chr14:55493428chr14:55606992ENST000002543012670_78114.0251.0RepeatNote=5
TgeneLGALS3chr14:55493428chr14:55606992ENST000002543012679_88114.0251.0RepeatNote=6%3B approximate
TgeneLGALS3chr14:55493428chr14:55606992ENST000002543012689_100114.0251.0RepeatNote=7%3B approximate
TgeneLGALS3chr14:55493429chr14:55606993ENST0000025430126101_109114.0251.0RepeatNote=8%3B approximate
TgeneLGALS3chr14:55493429chr14:55606993ENST000002543012636_44114.0251.0RepeatNote=1
TgeneLGALS3chr14:55493429chr14:55606993ENST000002543012645_53114.0251.0RepeatNote=2
TgeneLGALS3chr14:55493429chr14:55606993ENST000002543012654_62114.0251.0RepeatNote=3
TgeneLGALS3chr14:55493429chr14:55606993ENST000002543012663_69114.0251.0RepeatNote=4%3B approximate
TgeneLGALS3chr14:55493429chr14:55606993ENST000002543012670_78114.0251.0RepeatNote=5
TgeneLGALS3chr14:55493429chr14:55606993ENST000002543012679_88114.0251.0RepeatNote=6%3B approximate
TgeneLGALS3chr14:55493429chr14:55606993ENST000002543012689_100114.0251.0RepeatNote=7%3B approximate


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Fusion Gene Sequence for WDHD1-LGALS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000360586_ENST00000254301_TCGA-24-1464-01A_WDHD1_chr14_55493429_-_LGALS3_chr14_55606993_length(transcript)=686nt_BP=143nt
GCGGGAAGCAGCTCTTGTGGATCCTCAGTGGCGGAGGCTCGGTCACCCGGATAGGTAAAGGAAAACATGCCTGCCACACGGAAGCCAATG
AGATATGGGCATACAGAGGGACACACGGAGGTCTGTTTTGATGATTCTGGGAGATTGTGCCTTATAACCTGCCTTTGCCTGGGGGAGTGG
TGCCTCGCATGCTGATAACAATTCTGGGCACGGTGAAGCCCAATGCAAACAGAATTGCTTTAGATTTCCAAAGAGGGAATGATGTTGCCT
TCCACTTTAACCCACGCTTCAATGAGAACAACAGGAGAGTCATTGTTTGCAATACAAAGCTGGATAATAACTGGGGAAGGGAAGAAAGAC
AGTCGGTTTTCCCATTTGAAAGTGGGAAACCATTCAAAATACAAGTACTGGTTGAACCTGACCACTTCAAGGTTGCAGTGAATGATGCTC
ACTTGTTGCAGTACAATCATCGGGTTAAAAAACTCAATGAAATCAGCAAACTGGGAATTTCTGGTGACATAGACCTCACCAGTGCTTCAT
ATACCATGATATAATCTGAAAGGGGCAGATTAAAAAAAAAAAAAGAATCTAAACCTTACATGTGTAAAGGTTTCATGTTCACTGTGAGTG

>In-frame_ENST00000360586_ENST00000254301_TCGA-24-1464-01A_WDHD1_chr14_55493429_-_LGALS3_chr14_55606993_length(amino acids)=131AA_start in transcript=158_stop in transcript=553
MPLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNNWGREERQSVFPFESGKPFKIQVLVEPDHF

--------------------------------------------------------------
>In-frame_ENST00000360586_ENST00000254301_TCGA-24-1464_WDHD1_chr14_55493428_-_LGALS3_chr14_55606992_length(transcript)=686nt_BP=143nt
GCGGGAAGCAGCTCTTGTGGATCCTCAGTGGCGGAGGCTCGGTCACCCGGATAGGTAAAGGAAAACATGCCTGCCACACGGAAGCCAATG
AGATATGGGCATACAGAGGGACACACGGAGGTCTGTTTTGATGATTCTGGGAGATTGTGCCTTATAACCTGCCTTTGCCTGGGGGAGTGG
TGCCTCGCATGCTGATAACAATTCTGGGCACGGTGAAGCCCAATGCAAACAGAATTGCTTTAGATTTCCAAAGAGGGAATGATGTTGCCT
TCCACTTTAACCCACGCTTCAATGAGAACAACAGGAGAGTCATTGTTTGCAATACAAAGCTGGATAATAACTGGGGAAGGGAAGAAAGAC
AGTCGGTTTTCCCATTTGAAAGTGGGAAACCATTCAAAATACAAGTACTGGTTGAACCTGACCACTTCAAGGTTGCAGTGAATGATGCTC
ACTTGTTGCAGTACAATCATCGGGTTAAAAAACTCAATGAAATCAGCAAACTGGGAATTTCTGGTGACATAGACCTCACCAGTGCTTCAT
ATACCATGATATAATCTGAAAGGGGCAGATTAAAAAAAAAAAAAGAATCTAAACCTTACATGTGTAAAGGTTTCATGTTCACTGTGAGTG

>In-frame_ENST00000360586_ENST00000254301_TCGA-24-1464_WDHD1_chr14_55493428_-_LGALS3_chr14_55606992_length(amino acids)=131AA_start in transcript=158_stop in transcript=553
MPLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNNWGREERQSVFPFESGKPFKIQVLVEPDHF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for WDHD1-LGALS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WDHD1-LGALS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WDHD1-LGALS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLGALS3C0023893Liver Cirrhosis, Experimental2CTD_human
TgeneLGALS3C0000786Spontaneous abortion1CTD_human
TgeneLGALS3C0000822Abortion, Tubal1CTD_human
TgeneLGALS3C0007621Neoplastic Cell Transformation1CTD_human
TgeneLGALS3C0014859Esophageal Neoplasms1CTD_human
TgeneLGALS3C0016059Fibrosis1CTD_human
TgeneLGALS3C0019193Hepatitis, Toxic1CTD_human
TgeneLGALS3C0024623Malignant neoplasm of stomach1CTD_human
TgeneLGALS3C0025202melanoma1CTD_human
TgeneLGALS3C0027051Myocardial Infarction1CTD_human
TgeneLGALS3C0027540Necrosis1CTD_human
TgeneLGALS3C0027627Neoplasm Metastasis1CTD_human
TgeneLGALS3C0027697Nephritis1CTD_human
TgeneLGALS3C0038356Stomach Neoplasms1CTD_human
TgeneLGALS3C0042373Vascular Diseases1CTD_human
TgeneLGALS3C0546837Malignant neoplasm of esophagus1CTD_human
TgeneLGALS3C0860207Drug-Induced Liver Disease1CTD_human
TgeneLGALS3C1262760Hepatitis, Drug-Induced1CTD_human
TgeneLGALS3C1536220ST segment elevation myocardial infarction1CTD_human
TgeneLGALS3C1623038Cirrhosis1CTD_human
TgeneLGALS3C1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneLGALS3C3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneLGALS3C3830362Early Pregnancy Loss1CTD_human
TgeneLGALS3C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneLGALS3C4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneLGALS3C4552766Miscarriage1CTD_human