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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WDR41-ADSL (FusionGDB2 ID:98302)

Fusion Gene Summary for WDR41-ADSL

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR41-ADSL
Fusion gene ID: 98302
HgeneTgene
Gene symbol

WDR41

ADSL

Gene ID

55255

158

Gene nameWD repeat domain 41adenylosuccinate lyase
SynonymsMSTP048AMPS|ASASE|ASL
Cytomap

5q13.3-q14.1

22q13.1

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 41adenylosuccinate lyaseadenylosuccinase
Modification date2020031320200315
UniProtAcc.

P30566

Ensembl transtripts involved in fusion geneENST00000512033, ENST00000296679, 
ENST00000414719, ENST00000507029, 
ENST00000216194, ENST00000454266, 
ENST00000342312, ENST00000480775, 
Fusion gene scores* DoF score6 X 6 X 4=1445 X 8 X 5=200
# samples 77
** MAII scorelog2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/200*10)=-1.51457317282976
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDR41 [Title/Abstract] AND ADSL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWDR41(76754886)-ADSL(40750251), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneADSL

GO:0006167

AMP biosynthetic process

11428554


check buttonFusion gene breakpoints across WDR41 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ADSL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-EM-A1CV-11AWDR41chr5

76754886

-ADSLchr22

40750251

+
ChimerDB4Non-CancerTCGA-EM-A1CV-11AWDR41chr5

76754886

-ADSLchr22

40750251

+


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Fusion Gene ORF analysis for WDR41-ADSL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000512033ENST00000216194WDR41chr5

76754886

-ADSLchr22

40750251

+
intron-3CDSENST00000512033ENST00000454266WDR41chr5

76754886

-ADSLchr22

40750251

+
intron-3CDSENST00000512033ENST00000342312WDR41chr5

76754886

-ADSLchr22

40750251

+
intron-intronENST00000512033ENST00000480775WDR41chr5

76754886

-ADSLchr22

40750251

+
In-frameENST00000296679ENST00000216194WDR41chr5

76754886

-ADSLchr22

40750251

+
In-frameENST00000296679ENST00000454266WDR41chr5

76754886

-ADSLchr22

40750251

+
In-frameENST00000296679ENST00000342312WDR41chr5

76754886

-ADSLchr22

40750251

+
5CDS-intronENST00000296679ENST00000480775WDR41chr5

76754886

-ADSLchr22

40750251

+
5UTR-3CDSENST00000414719ENST00000216194WDR41chr5

76754886

-ADSLchr22

40750251

+
5UTR-3CDSENST00000414719ENST00000454266WDR41chr5

76754886

-ADSLchr22

40750251

+
5UTR-3CDSENST00000414719ENST00000342312WDR41chr5

76754886

-ADSLchr22

40750251

+
5UTR-intronENST00000414719ENST00000480775WDR41chr5

76754886

-ADSLchr22

40750251

+
In-frameENST00000507029ENST00000216194WDR41chr5

76754886

-ADSLchr22

40750251

+
In-frameENST00000507029ENST00000454266WDR41chr5

76754886

-ADSLchr22

40750251

+
In-frameENST00000507029ENST00000342312WDR41chr5

76754886

-ADSLchr22

40750251

+
5CDS-intronENST00000507029ENST00000480775WDR41chr5

76754886

-ADSLchr22

40750251

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296679WDR41chr576754886-ENST00000216194ADSLchr2240750251+23227873761839487
ENST00000296679WDR41chr576754886-ENST00000454266ADSLchr2240750251+19327873761839487
ENST00000296679WDR41chr576754886-ENST00000342312ADSLchr2240750251+21377873761662428
ENST00000507029WDR41chr576754886-ENST00000216194ADSLchr2240750251+1877342961394432
ENST00000507029WDR41chr576754886-ENST00000454266ADSLchr2240750251+1487342961394432
ENST00000507029WDR41chr576754886-ENST00000342312ADSLchr2240750251+1692342961217373

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296679ENST00000216194WDR41chr576754886-ADSLchr2240750251+0.0016362580.9983638
ENST00000296679ENST00000454266WDR41chr576754886-ADSLchr2240750251+0.0031477240.99685234
ENST00000296679ENST00000342312WDR41chr576754886-ADSLchr2240750251+0.0021470620.9978529
ENST00000507029ENST00000216194WDR41chr576754886-ADSLchr2240750251+0.0011955090.99880445
ENST00000507029ENST00000454266WDR41chr576754886-ADSLchr2240750251+0.0023177810.9976822
ENST00000507029ENST00000342312WDR41chr576754886-ADSLchr2240750251+0.0011064480.99889356

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Fusion Genomic Features for WDR41-ADSL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
WDR41chr576754886-ADSLchr2240750251+0.389233620.6107664
WDR41chr576754886-ADSLchr2240750251+0.389233620.6107664

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for WDR41-ADSL


check button Go to

FGviewer for the breakpoints of chr5:76754886-chr22:40750251

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ADSL

P30566

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. {ECO:0000269|PubMed:10888601}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR41chr5:76754886chr22:40750251ENST00000296679-51340_79137.0460.0RepeatNote=WD 1
HgeneWDR41chr5:76754886chr22:40750251ENST00000296679-51382_128137.0460.0RepeatNote=WD 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR41chr5:76754886chr22:40750251ENST00000296679-513131_168137.0460.0RepeatNote=WD 3
HgeneWDR41chr5:76754886chr22:40750251ENST00000296679-513220_258137.0460.0RepeatNote=WD 4
HgeneWDR41chr5:76754886chr22:40750251ENST00000296679-513321_359137.0460.0RepeatNote=WD 5
HgeneWDR41chr5:76754886chr22:40750251ENST00000296679-513403_441137.0460.0RepeatNote=WD 6
TgeneADSLchr5:76754886chr22:40750251ENST00000216194213111_112134.0485.0RegionNote=Substrate binding
TgeneADSLchr5:76754886chr22:40750251ENST0000021619421320_21134.0485.0RegionNote=Substrate binding%3B shared with neighboring subunit
TgeneADSLchr5:76754886chr22:40750251ENST0000021619421385_87134.0485.0RegionNote=Substrate binding
TgeneADSLchr5:76754886chr22:40750251ENST00000342312212111_112134.0426.0RegionNote=Substrate binding
TgeneADSLchr5:76754886chr22:40750251ENST0000034231221220_21134.0426.0RegionNote=Substrate binding%3B shared with neighboring subunit
TgeneADSLchr5:76754886chr22:40750251ENST0000034231221285_87134.0426.0RegionNote=Substrate binding


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Fusion Gene Sequence for WDR41-ADSL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000296679_ENST00000216194_TCGA-EM-A1CV-11A_WDR41_chr5_76754886_-_ADSL_chr22_40750251_length(transcript)=2322nt_BP=787nt
GTCGGGTTGCTGCTCCGCGCGCGTCCACCAGGGGCCGCTCGAGCTACCTAAGCTCCGTGCGCTACCCGGCGGCGCTCCCGCGCGTGCTCA
CTCGGAGCAGCGCGCGCCCCGCAATCGCCGCAGCCGCCCCCGCCGTCGGCCGCCGCACCCCAAGCGACTGCCCAAACTAAGCCTCCGTGG
CTGGGTACGGGAGCGCTTTGGGGACAAAAATTCTCCCTCAACTGTGGTCTGCATTCCTTCGGCCCGTGGGCTGATCTGGGGCGGGAAGTA
TTAGCGTCTCAGTTGCGCTGCAGCCGGGGAGGAAGGAGGAGGCCGAGCCTGGGGCGGAGTTTGGGCTGACTGGGGCTGGACCGGGCAAGA
CGCCGCCGCTGCCCGGATGTTGCGATGGCTGATCGGGGGAGGCCGAGAACCGCAGGGACTGGCCGAGAAATCTCCTTTACAGACAATAGG
TGAAGAACAAACCCAGAATCCCTACACTGAACTGCTAGTACTGAAGGCTCATCATGATATTGTACGATTTCTGGTACAGTTAGATGACTA
CAGATTTGCATCTGCTGGTGATGATGGAATTGTAGTTGTGTGGAATGCCCAGACAGGGGAAAAACTTTTAGAACTGAATGGACACACTCA
AAAGATAACAGCTATTATTACATTTCCTTCCTTGGAATCTTGTGAAGAGAAAAATCAACTCATCTTGACAGCCTCTGCTGATAGAACAGT
TATTGTGTGGGATGGTGATACTACCAGACAAGTTCAGAGAATATCATGCTTCCAGTCTACTGTAAAGCTTGCCAGAGTGATCTCTCGGCT
TGCCGACTTTGCTAAGGAACGAGCCAGTCTACCCACATTAGGTTTCACACATTTCCAGCCTGCACAGCTGACCACAGTTGGGAAACGTTG
CTGTCTTTGGATTCAGGATCTTTGCATGGATCTCCAGAACTTGAAGCGTGTCCGAGATGACCTGCGCTTCCGGGGAGTAAAGGGTACCAC
TGGCACTCAGGCCAGTTTCCTGCAGCTCTTTGAGGGAGATGACCATAAGGTAGAGCAGCTTGACAAGATGGTGACAGAAAAGGCAGGATT
TAAGAGAGCTTTCATCATCACAGGGCAGACATATACACGAAAAGTGGATATTGAAGTACTGTCTGTGCTGGCTAGCTTGGGGGCATCAGT
GCACAAGATTTGCACCGACATACGCCTCCTGGCAAACCTCAAGGAGATGGAGGAACCCTTTGAAAAACAGCAGATTGGCTCAAGTGCGAT
GCCATATAAGCGGAATCCCATGCGTTCAGAACGTTGCTGCAGTCTTGCCCGCCACCTGATGACCCTTGTCATGGACCCGCTACAGACAGC
ATCTGTCCAGTGGTTTGAACGCACACTGGATGATAGTGCCAACCGACGGATCTGTTTGGCCGAGGCATTTCTTACCGCAGATACTATATT
GAATACGCTGCAGAACATTTCTGAAGGATTGGTCGTGTACCCCAAAGTAATTGAACGGCGCATTCGGCAAGAGCTGCCTTTCATGGCCAC
AGAGAACATCATCATGGCCATGGTCAAAGCTGGAGGTAGCCGCCAGGATTGCCATGAGAAAATCAGAGTGCTTTCTCAGCAGGCAGCTTC
TGTGGTTAAGCAGGAAGGGGGTGACAATGACCTCATAGAGCGTATCCAGGTTGATGCCTACTTCAGTCCCATTCACTCCCAGTTGGATCA
TTTACTGGATCCTTCTTCTTTCACTGGTCGTGCCTCCCAGCAGGTGCAGAGATTCTTAGAAGAGGAGGTGTATCCCCTGTTAAAACCATA
TGAAAGCGTGATGAAGGTGAAAGCAGAATTATGTCTGTAGAGTTGGAAGAGAATTAAACGAAAATCATTGTTAATTGCTGAGGCATGAAA
ATTGTGTTACTATAATGCCTTATTTTACCTCGAGAATTGTTACCTTAAATTAGTACAGCACTTTCTTCTTCCCATGGTGCTTTCCTGTTT
CTCAGTCTCACATTTCTCAACAAGGCAAAAACAAAGAGCGTTGAAGTTGACTCTGCTCTTGCATAGTAAATGTAGTTCATACTTGATCTC
TGTTCTTTCAAGGCATATTTTCCAGCTGCCTCAAGTTTAGTCCTTTTCACGTGTTCATTTGCTTGTAAAGTAGCAAGAAATTTCTGGTCC
TGTCTTCTAAAAGTGAATTTGATCTAGGTCTAGCAAAATAACCTGGACTCAGTGATTGAGTCAATGGTCAGATACCTTTTATTTCGGTTA

>In-frame_ENST00000296679_ENST00000216194_TCGA-EM-A1CV-11A_WDR41_chr5_76754886_-_ADSL_chr22_40750251_length(amino acids)=487AA_start in transcript=376_stop in transcript=1839
MLRWLIGGGREPQGLAEKSPLQTIGEEQTQNPYTELLVLKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAI
ITFPSLESCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQ
DLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICT
DIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQN
ISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLDHLLDPS

--------------------------------------------------------------
>In-frame_ENST00000296679_ENST00000454266_TCGA-EM-A1CV-11A_WDR41_chr5_76754886_-_ADSL_chr22_40750251_length(transcript)=1932nt_BP=787nt
GTCGGGTTGCTGCTCCGCGCGCGTCCACCAGGGGCCGCTCGAGCTACCTAAGCTCCGTGCGCTACCCGGCGGCGCTCCCGCGCGTGCTCA
CTCGGAGCAGCGCGCGCCCCGCAATCGCCGCAGCCGCCCCCGCCGTCGGCCGCCGCACCCCAAGCGACTGCCCAAACTAAGCCTCCGTGG
CTGGGTACGGGAGCGCTTTGGGGACAAAAATTCTCCCTCAACTGTGGTCTGCATTCCTTCGGCCCGTGGGCTGATCTGGGGCGGGAAGTA
TTAGCGTCTCAGTTGCGCTGCAGCCGGGGAGGAAGGAGGAGGCCGAGCCTGGGGCGGAGTTTGGGCTGACTGGGGCTGGACCGGGCAAGA
CGCCGCCGCTGCCCGGATGTTGCGATGGCTGATCGGGGGAGGCCGAGAACCGCAGGGACTGGCCGAGAAATCTCCTTTACAGACAATAGG
TGAAGAACAAACCCAGAATCCCTACACTGAACTGCTAGTACTGAAGGCTCATCATGATATTGTACGATTTCTGGTACAGTTAGATGACTA
CAGATTTGCATCTGCTGGTGATGATGGAATTGTAGTTGTGTGGAATGCCCAGACAGGGGAAAAACTTTTAGAACTGAATGGACACACTCA
AAAGATAACAGCTATTATTACATTTCCTTCCTTGGAATCTTGTGAAGAGAAAAATCAACTCATCTTGACAGCCTCTGCTGATAGAACAGT
TATTGTGTGGGATGGTGATACTACCAGACAAGTTCAGAGAATATCATGCTTCCAGTCTACTGTAAAGCTTGCCAGAGTGATCTCTCGGCT
TGCCGACTTTGCTAAGGAACGAGCCAGTCTACCCACATTAGGTTTCACACATTTCCAGCCTGCACAGCTGACCACAGTTGGGAAACGTTG
CTGTCTTTGGATTCAGGATCTTTGCATGGATCTCCAGAACTTGAAGCGTGTCCGAGATGACCTGCGCTTCCGGGGAGTAAAGGGTACCAC
TGGCACTCAGGCCAGTTTCCTGCAGCTCTTTGAGGGAGATGACCATAAGGTAGAGCAGCTTGACAAGATGGTGACAGAAAAGGCAGGATT
TAAGAGAGCTTTCATCATCACAGGGCAGACATATACACGAAAAGTGGATATTGAAGTACTGTCTGTGCTGGCTAGCTTGGGGGCATCAGT
GCACAAGATTTGCACCGACATACGCCTCCTGGCAAACCTCAAGGAGATGGAGGAACCCTTTGAAAAACAGCAGATTGGCTCAAGTGCGAT
GCCATATAAGCGGAATCCCATGCGTTCAGAACGTTGCTGCAGTCTTGCCCGCCACCTGATGACCCTTGTCATGGACCCGCTACAGACAGC
ATCTGTCCAGTGGTTTGAACGCACACTGGATGATAGTGCCAACCGACGGATCTGTTTGGCCGAGGCATTTCTTACCGCAGATACTATATT
GAATACGCTGCAGAACATTTCTGAAGGATTGGTCGTGTACCCCAAAGTAATTGAACGGCGCATTCGGCAAGAGCTGCCTTTCATGGCCAC
AGAGAACATCATCATGGCCATGGTCAAAGCTGGAGGTAGCCGCCAGGATTGCCATGAGAAAATCAGAGTGCTTTCTCAGCAGGCAGCTTC
TGTGGTTAAGCAGGAAGGGGGTGACAATGACCTCATAGAGCGTATCCAGGTTGATGCCTACTTCAGTCCCATTCACTCCCAGTTGGATCA
TTTACTGGATCCTTCTTCTTTCACTGGTCGTGCCTCCCAGCAGGTGCAGAGATTCTTAGAAGAGGAGGTGTATCCCCTGTTAAAACCATA
TGAAAGCGTGATGAAGGTGAAAGCAGAATTATGTCTGTAGAGTTGGAAGAGAATTAAACGAAAATCATTGTTAATTGCTGAGGCATGAAA

>In-frame_ENST00000296679_ENST00000454266_TCGA-EM-A1CV-11A_WDR41_chr5_76754886_-_ADSL_chr22_40750251_length(amino acids)=487AA_start in transcript=376_stop in transcript=1839
MLRWLIGGGREPQGLAEKSPLQTIGEEQTQNPYTELLVLKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAI
ITFPSLESCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQ
DLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICT
DIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQN
ISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLDHLLDPS

--------------------------------------------------------------
>In-frame_ENST00000296679_ENST00000342312_TCGA-EM-A1CV-11A_WDR41_chr5_76754886_-_ADSL_chr22_40750251_length(transcript)=2137nt_BP=787nt
GTCGGGTTGCTGCTCCGCGCGCGTCCACCAGGGGCCGCTCGAGCTACCTAAGCTCCGTGCGCTACCCGGCGGCGCTCCCGCGCGTGCTCA
CTCGGAGCAGCGCGCGCCCCGCAATCGCCGCAGCCGCCCCCGCCGTCGGCCGCCGCACCCCAAGCGACTGCCCAAACTAAGCCTCCGTGG
CTGGGTACGGGAGCGCTTTGGGGACAAAAATTCTCCCTCAACTGTGGTCTGCATTCCTTCGGCCCGTGGGCTGATCTGGGGCGGGAAGTA
TTAGCGTCTCAGTTGCGCTGCAGCCGGGGAGGAAGGAGGAGGCCGAGCCTGGGGCGGAGTTTGGGCTGACTGGGGCTGGACCGGGCAAGA
CGCCGCCGCTGCCCGGATGTTGCGATGGCTGATCGGGGGAGGCCGAGAACCGCAGGGACTGGCCGAGAAATCTCCTTTACAGACAATAGG
TGAAGAACAAACCCAGAATCCCTACACTGAACTGCTAGTACTGAAGGCTCATCATGATATTGTACGATTTCTGGTACAGTTAGATGACTA
CAGATTTGCATCTGCTGGTGATGATGGAATTGTAGTTGTGTGGAATGCCCAGACAGGGGAAAAACTTTTAGAACTGAATGGACACACTCA
AAAGATAACAGCTATTATTACATTTCCTTCCTTGGAATCTTGTGAAGAGAAAAATCAACTCATCTTGACAGCCTCTGCTGATAGAACAGT
TATTGTGTGGGATGGTGATACTACCAGACAAGTTCAGAGAATATCATGCTTCCAGTCTACTGTAAAGCTTGCCAGAGTGATCTCTCGGCT
TGCCGACTTTGCTAAGGAACGAGCCAGTCTACCCACATTAGGTTTCACACATTTCCAGCCTGCACAGCTGACCACAGTTGGGAAACGTTG
CTGTCTTTGGATTCAGGATCTTTGCATGGATCTCCAGAACTTGAAGCGTGTCCGAGATGACCTGCGCTTCCGGGGAGTAAAGGGTACCAC
TGGCACTCAGGCCAGTTTCCTGCAGCTCTTTGAGGGAGATGACCATAAGGTAGAGCAGCTTGACAAGATGGTGACAGAAAAGGCAGGATT
TAAGAGAGCTTTCATCATCACAGGGCAGACATATACACGAAAAGTGGATATTGAAGTACTGTCTGTGCTGGCTAGCTTGGGGGCATCAGT
GCACAAGATTTGCACCGACATACGCCTCCTGGCAAACCTCAAGGAGATGGAGGAACCCTTTGAAAAACAGCAGATTGGCTCAAGTGCGAT
GCCATATAAGCGGAATCCCATGCGTTCAGAACGTTGCTGCAGTCTTGCCCGCCACCTGATGACCCTTGTCATGGACCCGCTACAGACAGC
ATCTGTCCAGTGGTTTGAACGCACACTGGATGATAGTGCCAACCGACGGATCTGTTTGGCCGAGGCATTTCTTACCGCAGATACTATATT
GAATACGCTGCAGAACATTTCTGAAGGATTGGTCGTGTACCCCAAAGTAATTGAACGGCGCATTCGGCAAGAGCTGCCTTTCATGGCCAC
AGAGAACATCATCATGGCCATGGTCAAAGCTGGAGGTAGCCGCCAGGTGCAGAGATTCTTAGAAGAGGAGGTGTATCCCCTGTTAAAACC
ATATGAAAGCGTGATGAAGGTGAAAGCAGAATTATGTCTGTAGAGTTGGAAGAGAATTAAACGAAAATCATTGTTAATTGCTGAGGCATG
AAAATTGTGTTACTATAATGCCTTATTTTACCTCGAGAATTGTTACCTTAAATTAGTACAGCACTTTCTTCTTCCCATGGTGCTTTCCTG
TTTCTCAGTCTCACATTTCTCAACAAGGCAAAAACAAAGAGCGTTGAAGTTGACTCTGCTCTTGCATAGTAAATGTAGTTCATACTTGAT
CTCTGTTCTTTCAAGGCATATTTTCCAGCTGCCTCAAGTTTAGTCCTTTTCACGTGTTCATTTGCTTGTAAAGTAGCAAGAAATTTCTGG
TCCTGTCTTCTAAAAGTGAATTTGATCTAGGTCTAGCAAAATAACCTGGACTCAGTGATTGAGTCAATGGTCAGATACCTTTTATTTCGG

>In-frame_ENST00000296679_ENST00000342312_TCGA-EM-A1CV-11A_WDR41_chr5_76754886_-_ADSL_chr22_40750251_length(amino acids)=428AA_start in transcript=376_stop in transcript=1662
MLRWLIGGGREPQGLAEKSPLQTIGEEQTQNPYTELLVLKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAI
ITFPSLESCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQ
DLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICT
DIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQN

--------------------------------------------------------------
>In-frame_ENST00000507029_ENST00000216194_TCGA-EM-A1CV-11A_WDR41_chr5_76754886_-_ADSL_chr22_40750251_length(transcript)=1877nt_BP=342nt
AGTTGCGCTGCAGCCGGGGAGGAAGGAGGAGGCCGAGCCTGGGGCGGAGTTTGGGCTGACTGGGGCTGGACCGGGCAAGACGCCGCCGCT
GCCCGGATGTTGCGATGGCTGATCGGGGGAGGCCGAGAACCGCAGGGACTGGCCGAGACAGGGGAAAAACTTTTAGAACTGAATGGACAC
ACTCAAAAGATAACAGCTATTATTACATTTCCTTCCTTGGAATCTTGTGAAGAGAAAAATCAACTCATCTTGACAGCCTCTGCTGATAGA
ACAGTTATTGTGTGGGATGGTGATACTACCAGACAAGTTCAGAGAATATCATGCTTCCAGTCTACTGTAAAGCTTGCCAGAGTGATCTCT
CGGCTTGCCGACTTTGCTAAGGAACGAGCCAGTCTACCCACATTAGGTTTCACACATTTCCAGCCTGCACAGCTGACCACAGTTGGGAAA
CGTTGCTGTCTTTGGATTCAGGATCTTTGCATGGATCTCCAGAACTTGAAGCGTGTCCGAGATGACCTGCGCTTCCGGGGAGTAAAGGGT
ACCACTGGCACTCAGGCCAGTTTCCTGCAGCTCTTTGAGGGAGATGACCATAAGGTAGAGCAGCTTGACAAGATGGTGACAGAAAAGGCA
GGATTTAAGAGAGCTTTCATCATCACAGGGCAGACATATACACGAAAAGTGGATATTGAAGTACTGTCTGTGCTGGCTAGCTTGGGGGCA
TCAGTGCACAAGATTTGCACCGACATACGCCTCCTGGCAAACCTCAAGGAGATGGAGGAACCCTTTGAAAAACAGCAGATTGGCTCAAGT
GCGATGCCATATAAGCGGAATCCCATGCGTTCAGAACGTTGCTGCAGTCTTGCCCGCCACCTGATGACCCTTGTCATGGACCCGCTACAG
ACAGCATCTGTCCAGTGGTTTGAACGCACACTGGATGATAGTGCCAACCGACGGATCTGTTTGGCCGAGGCATTTCTTACCGCAGATACT
ATATTGAATACGCTGCAGAACATTTCTGAAGGATTGGTCGTGTACCCCAAAGTAATTGAACGGCGCATTCGGCAAGAGCTGCCTTTCATG
GCCACAGAGAACATCATCATGGCCATGGTCAAAGCTGGAGGTAGCCGCCAGGATTGCCATGAGAAAATCAGAGTGCTTTCTCAGCAGGCA
GCTTCTGTGGTTAAGCAGGAAGGGGGTGACAATGACCTCATAGAGCGTATCCAGGTTGATGCCTACTTCAGTCCCATTCACTCCCAGTTG
GATCATTTACTGGATCCTTCTTCTTTCACTGGTCGTGCCTCCCAGCAGGTGCAGAGATTCTTAGAAGAGGAGGTGTATCCCCTGTTAAAA
CCATATGAAAGCGTGATGAAGGTGAAAGCAGAATTATGTCTGTAGAGTTGGAAGAGAATTAAACGAAAATCATTGTTAATTGCTGAGGCA
TGAAAATTGTGTTACTATAATGCCTTATTTTACCTCGAGAATTGTTACCTTAAATTAGTACAGCACTTTCTTCTTCCCATGGTGCTTTCC
TGTTTCTCAGTCTCACATTTCTCAACAAGGCAAAAACAAAGAGCGTTGAAGTTGACTCTGCTCTTGCATAGTAAATGTAGTTCATACTTG
ATCTCTGTTCTTTCAAGGCATATTTTCCAGCTGCCTCAAGTTTAGTCCTTTTCACGTGTTCATTTGCTTGTAAAGTAGCAAGAAATTTCT
GGTCCTGTCTTCTAAAAGTGAATTTGATCTAGGTCTAGCAAAATAACCTGGACTCAGTGATTGAGTCAATGGTCAGATACCTTTTATTTC

>In-frame_ENST00000507029_ENST00000216194_TCGA-EM-A1CV-11A_WDR41_chr5_76754886_-_ADSL_chr22_40750251_length(amino acids)=432AA_start in transcript=96_stop in transcript=1394
MLRWLIGGGREPQGLAETGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKLARVISRL
ADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGF
KRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTA
SVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAAS

--------------------------------------------------------------
>In-frame_ENST00000507029_ENST00000454266_TCGA-EM-A1CV-11A_WDR41_chr5_76754886_-_ADSL_chr22_40750251_length(transcript)=1487nt_BP=342nt
AGTTGCGCTGCAGCCGGGGAGGAAGGAGGAGGCCGAGCCTGGGGCGGAGTTTGGGCTGACTGGGGCTGGACCGGGCAAGACGCCGCCGCT
GCCCGGATGTTGCGATGGCTGATCGGGGGAGGCCGAGAACCGCAGGGACTGGCCGAGACAGGGGAAAAACTTTTAGAACTGAATGGACAC
ACTCAAAAGATAACAGCTATTATTACATTTCCTTCCTTGGAATCTTGTGAAGAGAAAAATCAACTCATCTTGACAGCCTCTGCTGATAGA
ACAGTTATTGTGTGGGATGGTGATACTACCAGACAAGTTCAGAGAATATCATGCTTCCAGTCTACTGTAAAGCTTGCCAGAGTGATCTCT
CGGCTTGCCGACTTTGCTAAGGAACGAGCCAGTCTACCCACATTAGGTTTCACACATTTCCAGCCTGCACAGCTGACCACAGTTGGGAAA
CGTTGCTGTCTTTGGATTCAGGATCTTTGCATGGATCTCCAGAACTTGAAGCGTGTCCGAGATGACCTGCGCTTCCGGGGAGTAAAGGGT
ACCACTGGCACTCAGGCCAGTTTCCTGCAGCTCTTTGAGGGAGATGACCATAAGGTAGAGCAGCTTGACAAGATGGTGACAGAAAAGGCA
GGATTTAAGAGAGCTTTCATCATCACAGGGCAGACATATACACGAAAAGTGGATATTGAAGTACTGTCTGTGCTGGCTAGCTTGGGGGCA
TCAGTGCACAAGATTTGCACCGACATACGCCTCCTGGCAAACCTCAAGGAGATGGAGGAACCCTTTGAAAAACAGCAGATTGGCTCAAGT
GCGATGCCATATAAGCGGAATCCCATGCGTTCAGAACGTTGCTGCAGTCTTGCCCGCCACCTGATGACCCTTGTCATGGACCCGCTACAG
ACAGCATCTGTCCAGTGGTTTGAACGCACACTGGATGATAGTGCCAACCGACGGATCTGTTTGGCCGAGGCATTTCTTACCGCAGATACT
ATATTGAATACGCTGCAGAACATTTCTGAAGGATTGGTCGTGTACCCCAAAGTAATTGAACGGCGCATTCGGCAAGAGCTGCCTTTCATG
GCCACAGAGAACATCATCATGGCCATGGTCAAAGCTGGAGGTAGCCGCCAGGATTGCCATGAGAAAATCAGAGTGCTTTCTCAGCAGGCA
GCTTCTGTGGTTAAGCAGGAAGGGGGTGACAATGACCTCATAGAGCGTATCCAGGTTGATGCCTACTTCAGTCCCATTCACTCCCAGTTG
GATCATTTACTGGATCCTTCTTCTTTCACTGGTCGTGCCTCCCAGCAGGTGCAGAGATTCTTAGAAGAGGAGGTGTATCCCCTGTTAAAA
CCATATGAAAGCGTGATGAAGGTGAAAGCAGAATTATGTCTGTAGAGTTGGAAGAGAATTAAACGAAAATCATTGTTAATTGCTGAGGCA

>In-frame_ENST00000507029_ENST00000454266_TCGA-EM-A1CV-11A_WDR41_chr5_76754886_-_ADSL_chr22_40750251_length(amino acids)=432AA_start in transcript=96_stop in transcript=1394
MLRWLIGGGREPQGLAETGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKLARVISRL
ADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGF
KRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTA
SVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAAS

--------------------------------------------------------------
>In-frame_ENST00000507029_ENST00000342312_TCGA-EM-A1CV-11A_WDR41_chr5_76754886_-_ADSL_chr22_40750251_length(transcript)=1692nt_BP=342nt
AGTTGCGCTGCAGCCGGGGAGGAAGGAGGAGGCCGAGCCTGGGGCGGAGTTTGGGCTGACTGGGGCTGGACCGGGCAAGACGCCGCCGCT
GCCCGGATGTTGCGATGGCTGATCGGGGGAGGCCGAGAACCGCAGGGACTGGCCGAGACAGGGGAAAAACTTTTAGAACTGAATGGACAC
ACTCAAAAGATAACAGCTATTATTACATTTCCTTCCTTGGAATCTTGTGAAGAGAAAAATCAACTCATCTTGACAGCCTCTGCTGATAGA
ACAGTTATTGTGTGGGATGGTGATACTACCAGACAAGTTCAGAGAATATCATGCTTCCAGTCTACTGTAAAGCTTGCCAGAGTGATCTCT
CGGCTTGCCGACTTTGCTAAGGAACGAGCCAGTCTACCCACATTAGGTTTCACACATTTCCAGCCTGCACAGCTGACCACAGTTGGGAAA
CGTTGCTGTCTTTGGATTCAGGATCTTTGCATGGATCTCCAGAACTTGAAGCGTGTCCGAGATGACCTGCGCTTCCGGGGAGTAAAGGGT
ACCACTGGCACTCAGGCCAGTTTCCTGCAGCTCTTTGAGGGAGATGACCATAAGGTAGAGCAGCTTGACAAGATGGTGACAGAAAAGGCA
GGATTTAAGAGAGCTTTCATCATCACAGGGCAGACATATACACGAAAAGTGGATATTGAAGTACTGTCTGTGCTGGCTAGCTTGGGGGCA
TCAGTGCACAAGATTTGCACCGACATACGCCTCCTGGCAAACCTCAAGGAGATGGAGGAACCCTTTGAAAAACAGCAGATTGGCTCAAGT
GCGATGCCATATAAGCGGAATCCCATGCGTTCAGAACGTTGCTGCAGTCTTGCCCGCCACCTGATGACCCTTGTCATGGACCCGCTACAG
ACAGCATCTGTCCAGTGGTTTGAACGCACACTGGATGATAGTGCCAACCGACGGATCTGTTTGGCCGAGGCATTTCTTACCGCAGATACT
ATATTGAATACGCTGCAGAACATTTCTGAAGGATTGGTCGTGTACCCCAAAGTAATTGAACGGCGCATTCGGCAAGAGCTGCCTTTCATG
GCCACAGAGAACATCATCATGGCCATGGTCAAAGCTGGAGGTAGCCGCCAGGTGCAGAGATTCTTAGAAGAGGAGGTGTATCCCCTGTTA
AAACCATATGAAAGCGTGATGAAGGTGAAAGCAGAATTATGTCTGTAGAGTTGGAAGAGAATTAAACGAAAATCATTGTTAATTGCTGAG
GCATGAAAATTGTGTTACTATAATGCCTTATTTTACCTCGAGAATTGTTACCTTAAATTAGTACAGCACTTTCTTCTTCCCATGGTGCTT
TCCTGTTTCTCAGTCTCACATTTCTCAACAAGGCAAAAACAAAGAGCGTTGAAGTTGACTCTGCTCTTGCATAGTAAATGTAGTTCATAC
TTGATCTCTGTTCTTTCAAGGCATATTTTCCAGCTGCCTCAAGTTTAGTCCTTTTCACGTGTTCATTTGCTTGTAAAGTAGCAAGAAATT
TCTGGTCCTGTCTTCTAAAAGTGAATTTGATCTAGGTCTAGCAAAATAACCTGGACTCAGTGATTGAGTCAATGGTCAGATACCTTTTAT

>In-frame_ENST00000507029_ENST00000342312_TCGA-EM-A1CV-11A_WDR41_chr5_76754886_-_ADSL_chr22_40750251_length(amino acids)=373AA_start in transcript=96_stop in transcript=1217
MLRWLIGGGREPQGLAETGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKLARVISRL
ADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGF
KRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTA
SVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQVQRFLEEEVYPLLKP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for WDR41-ADSL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WDR41-ADSL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WDR41-ADSL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneADSLC0268126Adenylosuccinate lyase deficiency (disorder)11CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneADSLC4721811Adenylosuccinate lyase deficiency type 13CTD_human
TgeneADSLC4721812Adenylosuccinate lyase deficiency type 43CTD_human
TgeneADSLC4721813Adenylosuccinate lyase deficiency type 33CTD_human
TgeneADSLC4721814Adenylosuccinate lyase deficiency type 23CTD_human
TgeneADSLC0004352Autistic Disorder1CTD_human
TgeneADSLC0543888Epileptic encephalopathy1GENOMICS_ENGLAND
TgeneADSLC3714756Intellectual Disability1GENOMICS_ENGLAND