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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WIPF2-PSMD3 (FusionGDB2 ID:98609)

Fusion Gene Summary for WIPF2-PSMD3

check button Fusion gene summary
Fusion gene informationFusion gene name: WIPF2-PSMD3
Fusion gene ID: 98609
HgeneTgene
Gene symbol

WIPF2

PSMD3

Gene ID

147179

5709

Gene nameWAS/WASL interacting protein family member 2proteasome 26S subunit, non-ATPase 3
SynonymsWICH|WIREP58|RPN3|S3|TSTA2
Cytomap

17q21.2

17q21.1

Type of geneprotein-codingprotein-coding
DescriptionWAS/WASL-interacting protein family member 2WASP-binding proteinWASP-interacting protein-related proteinWIP- and CR16-homologous proteinWIP-related protein26S proteasome non-ATPase regulatory subunit 326S proteasome regulatory subunit RPN326S proteasome regulatory subunit S3proteasome (prosome, macropain) 26S subunit, non-ATPase, 3proteasome subunit p58tissue specific transplantation antigen 2
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000494757, ENST00000323571, 
ENST00000585043, ENST00000394103, 
ENST00000536600, ENST00000583130, 
ENST00000264639, ENST00000541736, 
Fusion gene scores* DoF score40 X 12 X 16=768016 X 18 X 8=2304
# samples 5021
** MAII scorelog2(50/7680*10)=-3.94110631094643
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/2304*10)=-3.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WIPF2 [Title/Abstract] AND PSMD3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWIPF2(38375744)-PSMD3(38144936), # samples:2
Anticipated loss of major functional domain due to fusion event.WIPF2-PSMD3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
WIPF2-PSMD3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across WIPF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PSMD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8289WIPF2chr17

38375744

+PSMD3chr17

38144935

+
ChimerDB4STADTCGA-BR-8289-01AWIPF2chr17

38375744

+PSMD3chr17

38144936

+
ChimerDB4STADTCGA-EQ-8122-01AWIPF2chr17

38421398

+PSMD3chr17

38144936

+
ChimerDB4STADTCGA-BR-8289-01AWIPF2chr17

38375744

-PSMD3chr17

38144936

+


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Fusion Gene ORF analysis for WIPF2-PSMD3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000494757ENST00000264639WIPF2chr17

38375744

+PSMD3chr17

38144935

+
3UTR-3CDSENST00000494757ENST00000541736WIPF2chr17

38375744

+PSMD3chr17

38144935

+
5UTR-3CDSENST00000323571ENST00000264639WIPF2chr17

38375744

+PSMD3chr17

38144935

+
5UTR-3CDSENST00000323571ENST00000541736WIPF2chr17

38375744

+PSMD3chr17

38144935

+
5UTR-3CDSENST00000585043ENST00000264639WIPF2chr17

38375744

+PSMD3chr17

38144935

+
5UTR-3CDSENST00000585043ENST00000541736WIPF2chr17

38375744

+PSMD3chr17

38144935

+
5UTR-3CDSENST00000394103ENST00000264639WIPF2chr17

38375744

+PSMD3chr17

38144935

+
5UTR-3CDSENST00000394103ENST00000541736WIPF2chr17

38375744

+PSMD3chr17

38144935

+
5UTR-3CDSENST00000536600ENST00000264639WIPF2chr17

38375744

+PSMD3chr17

38144935

+
5UTR-3CDSENST00000536600ENST00000541736WIPF2chr17

38375744

+PSMD3chr17

38144935

+
intron-3CDSENST00000583130ENST00000264639WIPF2chr17

38375744

+PSMD3chr17

38144935

+
intron-3CDSENST00000583130ENST00000541736WIPF2chr17

38375744

+PSMD3chr17

38144935

+
3UTR-3CDSENST00000494757ENST00000264639WIPF2chr17

38375744

+PSMD3chr17

38144936

+
3UTR-3CDSENST00000494757ENST00000541736WIPF2chr17

38375744

+PSMD3chr17

38144936

+
5UTR-3CDSENST00000323571ENST00000264639WIPF2chr17

38375744

+PSMD3chr17

38144936

+
5UTR-3CDSENST00000323571ENST00000541736WIPF2chr17

38375744

+PSMD3chr17

38144936

+
5UTR-3CDSENST00000585043ENST00000264639WIPF2chr17

38375744

+PSMD3chr17

38144936

+
5UTR-3CDSENST00000585043ENST00000541736WIPF2chr17

38375744

+PSMD3chr17

38144936

+
5UTR-3CDSENST00000394103ENST00000264639WIPF2chr17

38375744

+PSMD3chr17

38144936

+
5UTR-3CDSENST00000394103ENST00000541736WIPF2chr17

38375744

+PSMD3chr17

38144936

+
5UTR-3CDSENST00000536600ENST00000264639WIPF2chr17

38375744

+PSMD3chr17

38144936

+
5UTR-3CDSENST00000536600ENST00000541736WIPF2chr17

38375744

+PSMD3chr17

38144936

+
intron-3CDSENST00000583130ENST00000264639WIPF2chr17

38375744

+PSMD3chr17

38144936

+
intron-3CDSENST00000583130ENST00000541736WIPF2chr17

38375744

+PSMD3chr17

38144936

+
3UTR-3CDSENST00000494757ENST00000264639WIPF2chr17

38421398

+PSMD3chr17

38144936

+
3UTR-3CDSENST00000494757ENST00000541736WIPF2chr17

38421398

+PSMD3chr17

38144936

+
Frame-shiftENST00000323571ENST00000264639WIPF2chr17

38421398

+PSMD3chr17

38144936

+
Frame-shiftENST00000323571ENST00000541736WIPF2chr17

38421398

+PSMD3chr17

38144936

+
Frame-shiftENST00000585043ENST00000264639WIPF2chr17

38421398

+PSMD3chr17

38144936

+
Frame-shiftENST00000585043ENST00000541736WIPF2chr17

38421398

+PSMD3chr17

38144936

+
intron-3CDSENST00000394103ENST00000264639WIPF2chr17

38421398

+PSMD3chr17

38144936

+
intron-3CDSENST00000394103ENST00000541736WIPF2chr17

38421398

+PSMD3chr17

38144936

+
intron-3CDSENST00000536600ENST00000264639WIPF2chr17

38421398

+PSMD3chr17

38144936

+
intron-3CDSENST00000536600ENST00000541736WIPF2chr17

38421398

+PSMD3chr17

38144936

+
Frame-shiftENST00000583130ENST00000264639WIPF2chr17

38421398

+PSMD3chr17

38144936

+
Frame-shiftENST00000583130ENST00000541736WIPF2chr17

38421398

+PSMD3chr17

38144936

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for WIPF2-PSMD3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
WIPF2chr1738375744+PSMD3chr1738144935+1.26E-141
WIPF2chr1738375744+PSMD3chr1738144935+1.26E-141
WIPF2chr1738421398+PSMD3chr1738144935+2.83E-101
WIPF2chr1738375744+PSMD3chr1738144935+1.26E-141
WIPF2chr1738375744+PSMD3chr1738144935+1.26E-141
WIPF2chr1738421398+PSMD3chr1738144935+2.83E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for WIPF2-PSMD3


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for WIPF2-PSMD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for WIPF2-PSMD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WIPF2-PSMD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WIPF2-PSMD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePSMD3C0019693HIV Infections1CTD_human
TgenePSMD3C4505456HIV Coinfection1CTD_human