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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:WRB-ERG (FusionGDB2 ID:98720) |
Fusion Gene Summary for WRB-ERG |
Fusion gene summary |
Fusion gene information | Fusion gene name: WRB-ERG | Fusion gene ID: 98720 | Hgene | Tgene | Gene symbol | WRB | ERG | Gene ID | 7485 | 2078 |
Gene name | guided entry of tail-anchored proteins factor 1 | ETS transcription factor ERG | |
Synonyms | CHD5|WRB | erg-3|p55 | |
Cytomap | 21q22.2 | 21q22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | tail-anchored protein insertion receptor WRBcongenital heart disease 5 proteintryptophan rich basic protein | transcriptional regulator ERGERG, ETS transcription factorFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian | |
Modification date | 20200313 | 20200320 | |
UniProtAcc | . | Q9Y282 | |
Ensembl transtripts involved in fusion gene | ENST00000333781, ENST00000541890, ENST00000398753, ENST00000380708, ENST00000466787, | ENST00000398907, ENST00000398905, ENST00000288319, ENST00000398897, ENST00000398911, ENST00000398910, ENST00000417133, ENST00000442448, ENST00000453032, ENST00000398919, ENST00000429727, ENST00000485493, | |
Fusion gene scores | * DoF score | 6 X 4 X 6=144 | 21 X 74 X 12=18648 |
# samples | 8 | 96 | |
** MAII score | log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(96/18648*10)=-4.27984269352035 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: WRB [Title/Abstract] AND ERG [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | WRB(40752412)-ERG(39817544), # samples:4 | ||
Anticipated loss of major functional domain due to fusion event. | WRB-ERG seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. WRB-ERG seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. WRB-ERG seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. WRB-ERG seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ERG | GO:0045944 | positive regulation of transcription by RNA polymerase II | 18195090|23913826 |
Fusion gene breakpoints across WRB (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across ERG (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | PAAD | TCGA-3E-AAAY-01A | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
ChimerDB4 | PAAD | TCGA-3E-AAAY | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
ChimerDB4 | PAAD | TCGA-3E-AAAY | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
ChimerDB4 | PAAD | TCGA-3E-AAAY | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
ChimerDB4 | PAAD | TCGA-3E-AAAY-01A | WRB | chr21 | 40752412 | - | ERG | chr21 | 39817544 | - |
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Fusion Gene ORF analysis for WRB-ERG |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000333781 | ENST00000398907 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
In-frame | ENST00000333781 | ENST00000398905 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
In-frame | ENST00000333781 | ENST00000288319 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5CDS-intron | ENST00000333781 | ENST00000398897 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5CDS-intron | ENST00000333781 | ENST00000398911 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5CDS-intron | ENST00000333781 | ENST00000398910 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5CDS-intron | ENST00000333781 | ENST00000417133 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5CDS-intron | ENST00000333781 | ENST00000442448 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5CDS-intron | ENST00000333781 | ENST00000453032 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5CDS-intron | ENST00000333781 | ENST00000398919 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5CDS-intron | ENST00000333781 | ENST00000429727 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5CDS-intron | ENST00000333781 | ENST00000485493 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
In-frame | ENST00000541890 | ENST00000398907 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
In-frame | ENST00000541890 | ENST00000398905 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
In-frame | ENST00000541890 | ENST00000288319 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5CDS-intron | ENST00000541890 | ENST00000398897 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5CDS-intron | ENST00000541890 | ENST00000398911 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5CDS-intron | ENST00000541890 | ENST00000398910 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5CDS-intron | ENST00000541890 | ENST00000417133 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5CDS-intron | ENST00000541890 | ENST00000442448 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5CDS-intron | ENST00000541890 | ENST00000453032 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5CDS-intron | ENST00000541890 | ENST00000398919 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5CDS-intron | ENST00000541890 | ENST00000429727 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5CDS-intron | ENST00000541890 | ENST00000485493 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5UTR-3CDS | ENST00000398753 | ENST00000398907 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5UTR-3CDS | ENST00000398753 | ENST00000398905 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5UTR-3CDS | ENST00000398753 | ENST00000288319 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5UTR-intron | ENST00000398753 | ENST00000398897 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5UTR-intron | ENST00000398753 | ENST00000398911 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5UTR-intron | ENST00000398753 | ENST00000398910 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5UTR-intron | ENST00000398753 | ENST00000417133 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5UTR-intron | ENST00000398753 | ENST00000442448 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5UTR-intron | ENST00000398753 | ENST00000453032 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5UTR-intron | ENST00000398753 | ENST00000398919 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5UTR-intron | ENST00000398753 | ENST00000429727 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
5UTR-intron | ENST00000398753 | ENST00000485493 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-3CDS | ENST00000380708 | ENST00000398907 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-3CDS | ENST00000380708 | ENST00000398905 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-3CDS | ENST00000380708 | ENST00000288319 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-intron | ENST00000380708 | ENST00000398897 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-intron | ENST00000380708 | ENST00000398911 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-intron | ENST00000380708 | ENST00000398910 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-intron | ENST00000380708 | ENST00000417133 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-intron | ENST00000380708 | ENST00000442448 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-intron | ENST00000380708 | ENST00000453032 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-intron | ENST00000380708 | ENST00000398919 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-intron | ENST00000380708 | ENST00000429727 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-intron | ENST00000380708 | ENST00000485493 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-3CDS | ENST00000466787 | ENST00000398907 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-3CDS | ENST00000466787 | ENST00000398905 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-3CDS | ENST00000466787 | ENST00000288319 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-intron | ENST00000466787 | ENST00000398897 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-intron | ENST00000466787 | ENST00000398911 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-intron | ENST00000466787 | ENST00000398910 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-intron | ENST00000466787 | ENST00000417133 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-intron | ENST00000466787 | ENST00000442448 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-intron | ENST00000466787 | ENST00000453032 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-intron | ENST00000466787 | ENST00000398919 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-intron | ENST00000466787 | ENST00000429727 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
intron-intron | ENST00000466787 | ENST00000485493 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - |
Frame-shift | ENST00000333781 | ENST00000398907 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
Frame-shift | ENST00000333781 | ENST00000398905 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
Frame-shift | ENST00000333781 | ENST00000288319 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5CDS-5UTR | ENST00000333781 | ENST00000398897 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5CDS-5UTR | ENST00000333781 | ENST00000398911 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5CDS-5UTR | ENST00000333781 | ENST00000398910 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5CDS-5UTR | ENST00000333781 | ENST00000417133 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5CDS-5UTR | ENST00000333781 | ENST00000442448 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5CDS-5UTR | ENST00000333781 | ENST00000453032 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5CDS-5UTR | ENST00000333781 | ENST00000398919 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5CDS-5UTR | ENST00000333781 | ENST00000429727 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5CDS-intron | ENST00000333781 | ENST00000485493 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
Frame-shift | ENST00000541890 | ENST00000398907 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
Frame-shift | ENST00000541890 | ENST00000398905 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
Frame-shift | ENST00000541890 | ENST00000288319 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5CDS-5UTR | ENST00000541890 | ENST00000398897 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5CDS-5UTR | ENST00000541890 | ENST00000398911 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5CDS-5UTR | ENST00000541890 | ENST00000398910 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5CDS-5UTR | ENST00000541890 | ENST00000417133 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5CDS-5UTR | ENST00000541890 | ENST00000442448 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5CDS-5UTR | ENST00000541890 | ENST00000453032 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5CDS-5UTR | ENST00000541890 | ENST00000398919 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5CDS-5UTR | ENST00000541890 | ENST00000429727 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5CDS-intron | ENST00000541890 | ENST00000485493 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5UTR-3CDS | ENST00000398753 | ENST00000398907 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5UTR-3CDS | ENST00000398753 | ENST00000398905 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5UTR-3CDS | ENST00000398753 | ENST00000288319 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5UTR-5UTR | ENST00000398753 | ENST00000398897 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5UTR-5UTR | ENST00000398753 | ENST00000398911 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5UTR-5UTR | ENST00000398753 | ENST00000398910 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5UTR-5UTR | ENST00000398753 | ENST00000417133 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5UTR-5UTR | ENST00000398753 | ENST00000442448 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5UTR-5UTR | ENST00000398753 | ENST00000453032 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5UTR-5UTR | ENST00000398753 | ENST00000398919 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5UTR-5UTR | ENST00000398753 | ENST00000429727 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
5UTR-intron | ENST00000398753 | ENST00000485493 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-3CDS | ENST00000380708 | ENST00000398907 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-3CDS | ENST00000380708 | ENST00000398905 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-3CDS | ENST00000380708 | ENST00000288319 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-5UTR | ENST00000380708 | ENST00000398897 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-5UTR | ENST00000380708 | ENST00000398911 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-5UTR | ENST00000380708 | ENST00000398910 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-5UTR | ENST00000380708 | ENST00000417133 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-5UTR | ENST00000380708 | ENST00000442448 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-5UTR | ENST00000380708 | ENST00000453032 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-5UTR | ENST00000380708 | ENST00000398919 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-5UTR | ENST00000380708 | ENST00000429727 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-intron | ENST00000380708 | ENST00000485493 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-3CDS | ENST00000466787 | ENST00000398907 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-3CDS | ENST00000466787 | ENST00000398905 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-3CDS | ENST00000466787 | ENST00000288319 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-5UTR | ENST00000466787 | ENST00000398897 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-5UTR | ENST00000466787 | ENST00000398911 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-5UTR | ENST00000466787 | ENST00000398910 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-5UTR | ENST00000466787 | ENST00000417133 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-5UTR | ENST00000466787 | ENST00000442448 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-5UTR | ENST00000466787 | ENST00000453032 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-5UTR | ENST00000466787 | ENST00000398919 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-5UTR | ENST00000466787 | ENST00000429727 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
intron-intron | ENST00000466787 | ENST00000485493 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39795483 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000333781 | WRB | chr21 | 40752412 | + | ENST00000398907 | ERG | chr21 | 39817544 | - | 4972 | 243 | 42 | 1595 | 517 |
ENST00000333781 | WRB | chr21 | 40752412 | + | ENST00000398905 | ERG | chr21 | 39817544 | - | 4969 | 243 | 42 | 1592 | 516 |
ENST00000333781 | WRB | chr21 | 40752412 | + | ENST00000288319 | ERG | chr21 | 39817544 | - | 5041 | 243 | 42 | 1664 | 540 |
ENST00000541890 | WRB | chr21 | 40752412 | + | ENST00000398907 | ERG | chr21 | 39817544 | - | 4862 | 133 | 31 | 1485 | 484 |
ENST00000541890 | WRB | chr21 | 40752412 | + | ENST00000398905 | ERG | chr21 | 39817544 | - | 4859 | 133 | 31 | 1482 | 483 |
ENST00000541890 | WRB | chr21 | 40752412 | + | ENST00000288319 | ERG | chr21 | 39817544 | - | 4931 | 133 | 31 | 1554 | 507 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000333781 | ENST00000398907 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - | 0.000810511 | 0.99918944 |
ENST00000333781 | ENST00000398905 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - | 0.000914862 | 0.9990852 |
ENST00000333781 | ENST00000288319 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - | 0.001000196 | 0.9989998 |
ENST00000541890 | ENST00000398907 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - | 0.000800453 | 0.99919957 |
ENST00000541890 | ENST00000398905 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - | 0.00089318 | 0.9991068 |
ENST00000541890 | ENST00000288319 | WRB | chr21 | 40752412 | + | ERG | chr21 | 39817544 | - | 0.000976811 | 0.9990232 |
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Fusion Genomic Features for WRB-ERG |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for WRB-ERG |
Go to FGviewer for the breakpoints of chr21:40752412-chr21:39817544 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | ERG |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Possible role in transport between endoplasmic reticulum and Golgi. {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000333781 | + | 1 | 5 | 1_8 | 34.0 | 175.0 | Topological domain | Lumenal |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000333781 | + | 1 | 5 | 9_29 | 34.0 | 175.0 | Transmembrane | Helical |
Tgene | ERG | chr21:40752412 | chr21:39817544 | ENST00000288319 | 0 | 10 | 311_391 | 6.0 | 480.0 | DNA binding | ETS | |
Tgene | ERG | chr21:40752412 | chr21:39817544 | ENST00000398897 | 0 | 9 | 311_391 | 0 | 364.0 | DNA binding | ETS | |
Tgene | ERG | chr21:40752412 | chr21:39817544 | ENST00000398911 | 1 | 10 | 311_391 | 13.0 | 463.0 | DNA binding | ETS | |
Tgene | ERG | chr21:40752412 | chr21:39817544 | ENST00000398919 | 2 | 12 | 311_391 | 13.0 | 487.0 | DNA binding | ETS | |
Tgene | ERG | chr21:40752412 | chr21:39817544 | ENST00000417133 | 2 | 12 | 311_391 | 13.0 | 487.0 | DNA binding | ETS | |
Tgene | ERG | chr21:40752412 | chr21:39817544 | ENST00000442448 | 2 | 11 | 311_391 | 13.0 | 463.0 | DNA binding | ETS | |
Tgene | ERG | chr21:40752412 | chr21:39817544 | ENST00000453032 | 0 | 9 | 311_391 | 0 | 388.0 | DNA binding | ETS | |
Tgene | ERG | chr21:40752412 | chr21:39817544 | ENST00000288319 | 0 | 10 | 113_199 | 6.0 | 480.0 | Domain | PNT | |
Tgene | ERG | chr21:40752412 | chr21:39817544 | ENST00000398897 | 0 | 9 | 113_199 | 0 | 364.0 | Domain | PNT | |
Tgene | ERG | chr21:40752412 | chr21:39817544 | ENST00000398911 | 1 | 10 | 113_199 | 13.0 | 463.0 | Domain | PNT | |
Tgene | ERG | chr21:40752412 | chr21:39817544 | ENST00000398919 | 2 | 12 | 113_199 | 13.0 | 487.0 | Domain | PNT | |
Tgene | ERG | chr21:40752412 | chr21:39817544 | ENST00000417133 | 2 | 12 | 113_199 | 13.0 | 487.0 | Domain | PNT | |
Tgene | ERG | chr21:40752412 | chr21:39817544 | ENST00000442448 | 2 | 11 | 113_199 | 13.0 | 463.0 | Domain | PNT | |
Tgene | ERG | chr21:40752412 | chr21:39817544 | ENST00000453032 | 0 | 9 | 113_199 | 0 | 388.0 | Domain | PNT |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000333781 | + | 1 | 5 | 39_94 | 34.0 | 175.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000380708 | + | 1 | 5 | 39_94 | 0 | 141.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000398753 | + | 1 | 5 | 39_94 | 0 | 141.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000333781 | + | 1 | 5 | 121_148 | 34.0 | 175.0 | Topological domain | Lumenal |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000333781 | + | 1 | 5 | 170_174 | 34.0 | 175.0 | Topological domain | Cytoplasmic |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000333781 | + | 1 | 5 | 30_99 | 34.0 | 175.0 | Topological domain | Cytoplasmic |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000380708 | + | 1 | 5 | 121_148 | 0 | 141.0 | Topological domain | Lumenal |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000380708 | + | 1 | 5 | 170_174 | 0 | 141.0 | Topological domain | Cytoplasmic |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000380708 | + | 1 | 5 | 1_8 | 0 | 141.0 | Topological domain | Lumenal |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000380708 | + | 1 | 5 | 30_99 | 0 | 141.0 | Topological domain | Cytoplasmic |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000398753 | + | 1 | 5 | 121_148 | 0 | 141.0 | Topological domain | Lumenal |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000398753 | + | 1 | 5 | 170_174 | 0 | 141.0 | Topological domain | Cytoplasmic |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000398753 | + | 1 | 5 | 1_8 | 0 | 141.0 | Topological domain | Lumenal |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000398753 | + | 1 | 5 | 30_99 | 0 | 141.0 | Topological domain | Cytoplasmic |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000333781 | + | 1 | 5 | 100_120 | 34.0 | 175.0 | Transmembrane | Helical |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000333781 | + | 1 | 5 | 149_169 | 34.0 | 175.0 | Transmembrane | Helical |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000380708 | + | 1 | 5 | 100_120 | 0 | 141.0 | Transmembrane | Helical |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000380708 | + | 1 | 5 | 149_169 | 0 | 141.0 | Transmembrane | Helical |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000380708 | + | 1 | 5 | 9_29 | 0 | 141.0 | Transmembrane | Helical |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000398753 | + | 1 | 5 | 100_120 | 0 | 141.0 | Transmembrane | Helical |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000398753 | + | 1 | 5 | 149_169 | 0 | 141.0 | Transmembrane | Helical |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000398753 | + | 1 | 5 | 9_29 | 0 | 141.0 | Transmembrane | Helical |
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Fusion Gene Sequence for WRB-ERG |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000333781_ENST00000398907_TCGA-3E-AAAY-01A_WRB_chr21_40752412_+_ERG_chr21_39817544_length(transcript)=4972nt_BP=243nt CGCGAGGGCGACGCAGTTCGCAGGCGCGTCGGCGCGCCTGTTCTGGGGCGCTTGGCTTCACCGCGCAGGCGCGGTCGCCGCTGTTGTTGT GGTCCCCATGGAGCTGCCGTAGCGGACCCAGCACAGCCAGGAGCGTCCGGGATGAGCTCAGCCGCGGCCGACCACTGGGCGTGGTTGCTG GTGCTCAGCTTCGTGTTTGGATGCAATGTTCTTAGGATCCTCCTCCCGTCCTTCTCATCCTTCGAAGCCTTATCAGTTGTGAGTGAGGAC CAGTCGTTGTTTGAGTGTGCCTACGGAACGCCACACCTGGCTAAGACAGAGATGACCGCGTCCTCCTCCAGCGACTATGGACAGACTTCC AAGATGAGCCCACGCGTCCCTCAGCAGGATTGGCTGTCTCAACCCCCAGCCAGGGTCACCATCAAAATGGAATGTAACCCTAGCCAGGTG AATGGCTCAAGGAACTCTCCTGATGAATGCAGTGTGGCCAAAGGCGGGAAGATGGTGGGCAGCCCAGACACCGTTGGGATGAACTACGGC AGCTACATGGAGGAGAAGCACATGCCACCCCCAAACATGACCACGAACGAGCGCAGAGTTATCGTGCCAGCAGATCCTACGCTATGGAGT ACAGACCATGTGCGGCAGTGGCTGGAGTGGGCGGTGAAAGAATATGGCCTTCCAGACGTCAACATCTTGTTATTCCAGAACATCGATGGG AAGGAACTGTGCAAGATGACCAAGGACGACTTCCAGAGGCTCACCCCCAGCTACAACGCCGACATCCTTCTCTCACATCTCCACTACCTC AGAGAGACTCCTCTTCCACATTTGACTTCAGATGATGTTGATAAAGCCTTACAAAACTCTCCACGGTTAATGCATGCTAGAAACACAGGG GGTGCAGCTTTTATTTTCCCAAATACTTCAGTATATCCTGAAGCTACGCAAAGAATTACAACTAGGCCAGCTGCTCAACCATCTCCTTCC ACAGTGCCCAAAACTGAAGACCAGCGTCCTCAGTTAGATCCTTATCAGATTCTTGGACCAACAAGTAGCCGCCTTGCAAATCCAGGCAGT GGCCAGATCCAGCTTTGGCAGTTCCTCCTGGAGCTCCTGTCGGACAGCTCCAACTCCAGCTGCATCACCTGGGAAGGCACCAACGGGGAG TTCAAGATGACGGATCCCGACGAGGTGGCCCGGCGCTGGGGAGAGCGGAAGAGCAAACCCAACATGAACTACGATAAGCTCAGCCGCGCC CTCCGTTACTACTATGACAAGAACATCATGACCAAGGTCCATGGGAAGCGCTACGCCTACAAGTTCGACTTCCACGGGATCGCCCAGGCC CTCCAGCCCCACCCCCCGGAGTCATCTCTGTACAAGTACCCCTCAGACCTCCCGTACATGGGCTCCTATCACGCCCACCCACAGAAGATG AACTTTGTGGCGCCCCACCCTCCAGCCCTCCCCGTGACATCTTCCAGTTTTTTTGCTGCCCCAAACCCATACTGGAATTCACCAACTGGG GGTATATACCCCAACACTAGGCTCCCCACCAGCCATATGCCTTCTCATCTGGGCACTTACTACTAAAGACCTGGCGGAGGCTTTTCCCAT CAGCGTGCATTCACCAGCCCATCGCCACAAACTCTATCGGAGAACATGAATCAAAAGTGCCTCAAGAGGAATGAAAAAAGCTTTACTGGG GCTGGGGAAGGAAGCCGGGGAAGAGATCCAAAGACTCTTGGGAGGGAGTTACTGAAGTCTTACTACAGAAATGAGGAGGATGCTAAAAAT GTCACGAATATGGACATATCATCTGTGGACTGACCTTGTAAAAGACAGTGTATGTAGAAGCATGAAGTCTTAAGGACAAAGTGCCAAAGA AAGTGGTCTTAAGAAATGTATAAACTTTAGAGTAGAGTTTGGAATCCCACTAATGCAAACTGGGATGAAACTAAAGCAATAGAAACAACA CAGTTTTGACCTAACATACCGTTTATAATGCCATTTTAAGGAAAACTACCTGTATTTAAAAATAGAAACATATCAAAAACAAGAGAAAAG ACACGAGAGAGACTGTGGCCCATCAACAGACGTTGATATGCAACTGCATGGCATGTGCTGTTTTGGTTGAAATCAAATACATTCCGTTTG ATGGACAGCTGTCAGCTTTCTCAAACTGTGAAGATGACCCAAAGTTTCCAACTCCTTTACAGTATTACCGGGACTATGAACTAAAAGGTG GGACTGAGGATGTGTATAGAGTGAGCGTGTGATTGTAGACAGAGGGGTGAAGAAGGAGGAGGAAGAGGCAGAGAAGGAGGAGACCAGGGC TGGGAAAGAAACTTCTCAAGCAATGAAGACTGGACTCAGGACATTTGGGGACTGTGTACAATGAGTTATGGAGACTCGAGGGTTCATGCA GTCAGTGTTATACCAAACCCAGTGTTAGGAGAAAGGACACAGCGTAATGGAGAAAGGGGAAGTAGTAGAATTCAGAAACAAAAATGCGCA TCTCTTTCTTTGTTTGTCAAATGAAAATTTTAACTGGAATTGTCTGATATTTAAGAGAAACATTCAGGACCTCATCATTATGTGGGGGCT TTGTTCTCCACAGGGTCAGGTAAGAGATGGCCTTCTTGGCTGCCACAATCAGAAATCACGCAGGCATTTTGGGTAGGCGGCCTCCAGTTT TCCTTTGAGTCGCGAACGCTGTGCGTTTGTCAGAATGAAGTATACAAGTCAATGTTTTTCCCCCTTTTTATATAATAATTATATAACTTA TGCATTTATACACTACGAGTTGATCTCGGCCAGCCAAAGACACACGACAAAAGAGACAATCGATATAATGTGGCCTTGAATTTTAACTCT GTATGCTTAATGTTTACAATATGAAGTTATTAGTTCTTAGAATGCAGAATGTATGTAATAAAATAAGCTTGGCCTAGCATGGCAAATCAG ATTTATACAGGAGTCTGCATTTGCACTTTTTTTAGTGACTAAAGTTGCTTAATGAAAACATGTGCTGAATGTTGTGGATTTTGTGTTATA ATTTACTTTGTCCAGGAACTTGTGCAAGGGAGAGCCAAGGAAATAGGATGTTTGGCACCCAAATGGCGTCAGCCTCTCCAGGTCCTTCTT GCCTCCCCTCCTGTCTTTTATTTCTAGCCCCTTTTGGAACAGAAGGACCCCGGGTTTCACATTGGAGCCTCCATATTTATGCCTGGAATG GAAAGAGGCCTATGAAGCTGGGGTTGTCATTGAGAAATTCTAGTTCAGCACCTGGTCACAAATCACCCTTAATTCCTGCTATGATTAAAA TACATTTGTTGAACAGTGAACAAGCTACCACTCGTAAGGCAAACTGTATTATTACTGGCAAATAAAGCGTCATGGATAGCTGCAATTTCT CACTTTACAGAAACAAGGGATAACGTCTAGATTTGCTGCGGGGTTTCTCTTTCAGGAGCTCTCACTAGGTAGACAGCTTTAGTCCTGCTA CATCAGAGTTACCTGGGCACTGTGGCTTGGGATTCACTAGCCCTGAGCCTGATGTTGCTGGCTATCCCTTGAAGACAATGTTTATTTCCA TAATCTAGAGTCAGTTTCCCTGGGCATCTTTTCTTTGAATCACAAATGCTGCCAACCTTGGTCCAGGTGAAGGCAACTCAAAAGGTGAAA ATACAAGGTGACCGTGCGAAGGCGCTAGCCGAAACATCTTAGCTGAATAGGTTTCTGAACTGGCCCTTTTCATAGCTGTTTCAGGGCCTG TTTTTTTCACGTTGCAGTCCTTTTGCTATGATTATGTGAAGTTGCCAAACCTCTGTGCTGTGGATGTTTTGGCAGTGGGCTTTGAAGTCG GCAGGACACGATTACCAATGCTCCTGACACCCCGTGTCATTTGGATTAGACGGAGCCCAACCATCCATCATTTTGCAGCAGCCTGGGAAG GCCCACAAAGTGCCCGTATCTCCTTAGGGAAAATAAATAAATACAATCATGAAAGCTGGCAGTTAGGCTGACCCAAACTGTGCTAATGGA AAAGATCAGTCATTTTTATTTTGGAATGCAAAGTCAAGACACACCTACATTCTTCATAGAAATACACATTTACTTGGATAATCACTCAGT TCTCTCTTCAAGACTGTCTCATGAGCAAGATCATAAAAACAAGACATGATTATCATATTCAATTTTAACAGATGTTTTCCATTAGATCCC TCAACCCTCCACCCCCAGTCCAGGTTATTAGCAAGTCTTATGAGCAACTGGGATAATTTTGGATAACATGATAATACTGAGTTCCTTCAA ATACATAATTCTTAAATTGTTTCAAAATGGCATTAACTCTCTGTTACTGTTGTAATCTAATTCCAAAGCCCCCTCCAGGTCATATTCATA ATTGCATGAACCTTTTCTCTCTGTTTGTCCCTGTCTCTTGGCTTGCCCTGATGTATACTCAGACTCCTGTACAATCTTACTCCTGCTGGC AAGAGATTTGTCTTCTTTTCTTGTCTTCAATTGGCTTTCGGGCCTTGTATGTGGTAAAATCACCAAATCACAGTCAAGACTGTGTTTTTG TTCCTAGTTTGATGCCCTTATGTCCCGGAGGGGTTCACAAAGTGCTTTGTCAGGACTGCTGCAGTTAGAAGGCTCACTGCTTCTCCTAAG CCTTCTGCACAGATGTGGCACCTGCAACCCAGGAGCAGGAGCCGGAGGAGCTGCCCTCTGACAGCAGGTGCAGCAGAGATGGCTACAGCT CAGGAGCTGGGAAGGTGATGGGGCACAGGGAAAGCACAGATGTTCTGCAGCGCCCCAAAGTGACCCATTGCCTGGAGAAAGAGAAGAAAA TATTTTTTAAAAAGCTAGTTTATTTAGCTTCTCATTAATTCATTCAAATAAAGTCGTGAGGTGACTAATTAGAGAATAAAAATTACTTTG >In-frame_ENST00000333781_ENST00000398907_TCGA-3E-AAAY-01A_WRB_chr21_40752412_+_ERG_chr21_39817544_length(amino acids)=517AA_start in transcript=42_stop in transcript=1595 MGRLASPRRRGRRCCCGPHGAAVADPAQPGASGMSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFEALSVVSEDQSLFECAYGTPHLA KTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMT TNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVD KALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLS DSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYP -------------------------------------------------------------- >In-frame_ENST00000333781_ENST00000398905_TCGA-3E-AAAY-01A_WRB_chr21_40752412_+_ERG_chr21_39817544_length(transcript)=4969nt_BP=243nt CGCGAGGGCGACGCAGTTCGCAGGCGCGTCGGCGCGCCTGTTCTGGGGCGCTTGGCTTCACCGCGCAGGCGCGGTCGCCGCTGTTGTTGT GGTCCCCATGGAGCTGCCGTAGCGGACCCAGCACAGCCAGGAGCGTCCGGGATGAGCTCAGCCGCGGCCGACCACTGGGCGTGGTTGCTG GTGCTCAGCTTCGTGTTTGGATGCAATGTTCTTAGGATCCTCCTCCCGTCCTTCTCATCCTTCGAAGCCTTATCAGTTGTGAGTGAGGAC CAGTCGTTGTTTGAGTGTGCCTACGGAACGCCACACCTGGCTAAGACAGAGATGACCGCGTCCTCCTCCAGCGACTATGGACAGACTTCC AAGATGAGCCCACGCGTCCCTCAGCAGGATTGGCTGTCTCAACCCCCAGCCAGGGTCACCATCAAAATGGAATGTAACCCTAGCCAGGTG AATGGCTCAAGGAACTCTCCTGATGAATGCAGTGTGGCCAAAGGCGGGAAGATGGTGGGCAGCCCAGACACCGTTGGGATGAACTACGGC AGCTACATGGAGGAGAAGCACATGCCACCCCCAAACATGACCACGAACGAGCGCAGAGTTATCGTGCCAGCAGATCCTACGCTATGGAGT ACAGACCATGTGCGGCAGTGGCTGGAGTGGGCGGTGAAAGAATATGGCCTTCCAGACGTCAACATCTTGTTATTCCAGAACATCGATGGG AAGGAACTGTGCAAGATGACCAAGGACGACTTCCAGAGGCTCACCCCCAGCTACAACGCCGACATCCTTCTCTCACATCTCCACTACCTC AGAGAGACTCCTCTTCCACATTTGACTTCAGATGATGTTGATAAAGCCTTACAAAACTCTCCACGGTTAATGCATGCTAGAAACACAGAT TTACCATATGAGCCCCCCAGGAGATCAGCCTGGACCGGTCACGGCCACCCCACGCCCCAGTCGAAAGCTGCTCAACCATCTCCTTCCACA GTGCCCAAAACTGAAGACCAGCGTCCTCAGTTAGATCCTTATCAGATTCTTGGACCAACAAGTAGCCGCCTTGCAAATCCAGGCAGTGGC CAGATCCAGCTTTGGCAGTTCCTCCTGGAGCTCCTGTCGGACAGCTCCAACTCCAGCTGCATCACCTGGGAAGGCACCAACGGGGAGTTC AAGATGACGGATCCCGACGAGGTGGCCCGGCGCTGGGGAGAGCGGAAGAGCAAACCCAACATGAACTACGATAAGCTCAGCCGCGCCCTC CGTTACTACTATGACAAGAACATCATGACCAAGGTCCATGGGAAGCGCTACGCCTACAAGTTCGACTTCCACGGGATCGCCCAGGCCCTC CAGCCCCACCCCCCGGAGTCATCTCTGTACAAGTACCCCTCAGACCTCCCGTACATGGGCTCCTATCACGCCCACCCACAGAAGATGAAC TTTGTGGCGCCCCACCCTCCAGCCCTCCCCGTGACATCTTCCAGTTTTTTTGCTGCCCCAAACCCATACTGGAATTCACCAACTGGGGGT ATATACCCCAACACTAGGCTCCCCACCAGCCATATGCCTTCTCATCTGGGCACTTACTACTAAAGACCTGGCGGAGGCTTTTCCCATCAG CGTGCATTCACCAGCCCATCGCCACAAACTCTATCGGAGAACATGAATCAAAAGTGCCTCAAGAGGAATGAAAAAAGCTTTACTGGGGCT GGGGAAGGAAGCCGGGGAAGAGATCCAAAGACTCTTGGGAGGGAGTTACTGAAGTCTTACTACAGAAATGAGGAGGATGCTAAAAATGTC ACGAATATGGACATATCATCTGTGGACTGACCTTGTAAAAGACAGTGTATGTAGAAGCATGAAGTCTTAAGGACAAAGTGCCAAAGAAAG TGGTCTTAAGAAATGTATAAACTTTAGAGTAGAGTTTGGAATCCCACTAATGCAAACTGGGATGAAACTAAAGCAATAGAAACAACACAG TTTTGACCTAACATACCGTTTATAATGCCATTTTAAGGAAAACTACCTGTATTTAAAAATAGAAACATATCAAAAACAAGAGAAAAGACA CGAGAGAGACTGTGGCCCATCAACAGACGTTGATATGCAACTGCATGGCATGTGCTGTTTTGGTTGAAATCAAATACATTCCGTTTGATG GACAGCTGTCAGCTTTCTCAAACTGTGAAGATGACCCAAAGTTTCCAACTCCTTTACAGTATTACCGGGACTATGAACTAAAAGGTGGGA CTGAGGATGTGTATAGAGTGAGCGTGTGATTGTAGACAGAGGGGTGAAGAAGGAGGAGGAAGAGGCAGAGAAGGAGGAGACCAGGGCTGG GAAAGAAACTTCTCAAGCAATGAAGACTGGACTCAGGACATTTGGGGACTGTGTACAATGAGTTATGGAGACTCGAGGGTTCATGCAGTC AGTGTTATACCAAACCCAGTGTTAGGAGAAAGGACACAGCGTAATGGAGAAAGGGGAAGTAGTAGAATTCAGAAACAAAAATGCGCATCT CTTTCTTTGTTTGTCAAATGAAAATTTTAACTGGAATTGTCTGATATTTAAGAGAAACATTCAGGACCTCATCATTATGTGGGGGCTTTG TTCTCCACAGGGTCAGGTAAGAGATGGCCTTCTTGGCTGCCACAATCAGAAATCACGCAGGCATTTTGGGTAGGCGGCCTCCAGTTTTCC TTTGAGTCGCGAACGCTGTGCGTTTGTCAGAATGAAGTATACAAGTCAATGTTTTTCCCCCTTTTTATATAATAATTATATAACTTATGC ATTTATACACTACGAGTTGATCTCGGCCAGCCAAAGACACACGACAAAAGAGACAATCGATATAATGTGGCCTTGAATTTTAACTCTGTA TGCTTAATGTTTACAATATGAAGTTATTAGTTCTTAGAATGCAGAATGTATGTAATAAAATAAGCTTGGCCTAGCATGGCAAATCAGATT TATACAGGAGTCTGCATTTGCACTTTTTTTAGTGACTAAAGTTGCTTAATGAAAACATGTGCTGAATGTTGTGGATTTTGTGTTATAATT TACTTTGTCCAGGAACTTGTGCAAGGGAGAGCCAAGGAAATAGGATGTTTGGCACCCAAATGGCGTCAGCCTCTCCAGGTCCTTCTTGCC TCCCCTCCTGTCTTTTATTTCTAGCCCCTTTTGGAACAGAAGGACCCCGGGTTTCACATTGGAGCCTCCATATTTATGCCTGGAATGGAA AGAGGCCTATGAAGCTGGGGTTGTCATTGAGAAATTCTAGTTCAGCACCTGGTCACAAATCACCCTTAATTCCTGCTATGATTAAAATAC ATTTGTTGAACAGTGAACAAGCTACCACTCGTAAGGCAAACTGTATTATTACTGGCAAATAAAGCGTCATGGATAGCTGCAATTTCTCAC TTTACAGAAACAAGGGATAACGTCTAGATTTGCTGCGGGGTTTCTCTTTCAGGAGCTCTCACTAGGTAGACAGCTTTAGTCCTGCTACAT CAGAGTTACCTGGGCACTGTGGCTTGGGATTCACTAGCCCTGAGCCTGATGTTGCTGGCTATCCCTTGAAGACAATGTTTATTTCCATAA TCTAGAGTCAGTTTCCCTGGGCATCTTTTCTTTGAATCACAAATGCTGCCAACCTTGGTCCAGGTGAAGGCAACTCAAAAGGTGAAAATA CAAGGTGACCGTGCGAAGGCGCTAGCCGAAACATCTTAGCTGAATAGGTTTCTGAACTGGCCCTTTTCATAGCTGTTTCAGGGCCTGTTT TTTTCACGTTGCAGTCCTTTTGCTATGATTATGTGAAGTTGCCAAACCTCTGTGCTGTGGATGTTTTGGCAGTGGGCTTTGAAGTCGGCA GGACACGATTACCAATGCTCCTGACACCCCGTGTCATTTGGATTAGACGGAGCCCAACCATCCATCATTTTGCAGCAGCCTGGGAAGGCC CACAAAGTGCCCGTATCTCCTTAGGGAAAATAAATAAATACAATCATGAAAGCTGGCAGTTAGGCTGACCCAAACTGTGCTAATGGAAAA GATCAGTCATTTTTATTTTGGAATGCAAAGTCAAGACACACCTACATTCTTCATAGAAATACACATTTACTTGGATAATCACTCAGTTCT CTCTTCAAGACTGTCTCATGAGCAAGATCATAAAAACAAGACATGATTATCATATTCAATTTTAACAGATGTTTTCCATTAGATCCCTCA ACCCTCCACCCCCAGTCCAGGTTATTAGCAAGTCTTATGAGCAACTGGGATAATTTTGGATAACATGATAATACTGAGTTCCTTCAAATA CATAATTCTTAAATTGTTTCAAAATGGCATTAACTCTCTGTTACTGTTGTAATCTAATTCCAAAGCCCCCTCCAGGTCATATTCATAATT GCATGAACCTTTTCTCTCTGTTTGTCCCTGTCTCTTGGCTTGCCCTGATGTATACTCAGACTCCTGTACAATCTTACTCCTGCTGGCAAG AGATTTGTCTTCTTTTCTTGTCTTCAATTGGCTTTCGGGCCTTGTATGTGGTAAAATCACCAAATCACAGTCAAGACTGTGTTTTTGTTC CTAGTTTGATGCCCTTATGTCCCGGAGGGGTTCACAAAGTGCTTTGTCAGGACTGCTGCAGTTAGAAGGCTCACTGCTTCTCCTAAGCCT TCTGCACAGATGTGGCACCTGCAACCCAGGAGCAGGAGCCGGAGGAGCTGCCCTCTGACAGCAGGTGCAGCAGAGATGGCTACAGCTCAG GAGCTGGGAAGGTGATGGGGCACAGGGAAAGCACAGATGTTCTGCAGCGCCCCAAAGTGACCCATTGCCTGGAGAAAGAGAAGAAAATAT TTTTTAAAAAGCTAGTTTATTTAGCTTCTCATTAATTCATTCAAATAAAGTCGTGAGGTGACTAATTAGAGAATAAAAATTACTTTGGAC >In-frame_ENST00000333781_ENST00000398905_TCGA-3E-AAAY-01A_WRB_chr21_40752412_+_ERG_chr21_39817544_length(amino acids)=516AA_start in transcript=42_stop in transcript=1592 MGRLASPRRRGRRCCCGPHGAAVADPAQPGASGMSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFEALSVVSEDQSLFECAYGTPHLA KTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMT TNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVD KALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSD SSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPS -------------------------------------------------------------- >In-frame_ENST00000333781_ENST00000288319_TCGA-3E-AAAY-01A_WRB_chr21_40752412_+_ERG_chr21_39817544_length(transcript)=5041nt_BP=243nt CGCGAGGGCGACGCAGTTCGCAGGCGCGTCGGCGCGCCTGTTCTGGGGCGCTTGGCTTCACCGCGCAGGCGCGGTCGCCGCTGTTGTTGT GGTCCCCATGGAGCTGCCGTAGCGGACCCAGCACAGCCAGGAGCGTCCGGGATGAGCTCAGCCGCGGCCGACCACTGGGCGTGGTTGCTG GTGCTCAGCTTCGTGTTTGGATGCAATGTTCTTAGGATCCTCCTCCCGTCCTTCTCATCCTTCGAAGCCTTATCAGTTGTGAGTGAGGAC CAGTCGTTGTTTGAGTGTGCCTACGGAACGCCACACCTGGCTAAGACAGAGATGACCGCGTCCTCCTCCAGCGACTATGGACAGACTTCC AAGATGAGCCCACGCGTCCCTCAGCAGGATTGGCTGTCTCAACCCCCAGCCAGGGTCACCATCAAAATGGAATGTAACCCTAGCCAGGTG AATGGCTCAAGGAACTCTCCTGATGAATGCAGTGTGGCCAAAGGCGGGAAGATGGTGGGCAGCCCAGACACCGTTGGGATGAACTACGGC AGCTACATGGAGGAGAAGCACATGCCACCCCCAAACATGACCACGAACGAGCGCAGAGTTATCGTGCCAGCAGATCCTACGCTATGGAGT ACAGACCATGTGCGGCAGTGGCTGGAGTGGGCGGTGAAAGAATATGGCCTTCCAGACGTCAACATCTTGTTATTCCAGAACATCGATGGG AAGGAACTGTGCAAGATGACCAAGGACGACTTCCAGAGGCTCACCCCCAGCTACAACGCCGACATCCTTCTCTCACATCTCCACTACCTC AGAGAGACTCCTCTTCCACATTTGACTTCAGATGATGTTGATAAAGCCTTACAAAACTCTCCACGGTTAATGCATGCTAGAAACACAGGG GGTGCAGCTTTTATTTTCCCAAATACTTCAGTATATCCTGAAGCTACGCAAAGAATTACAACTAGGCCAGATTTACCATATGAGCCCCCC AGGAGATCAGCCTGGACCGGTCACGGCCACCCCACGCCCCAGTCGAAAGCTGCTCAACCATCTCCTTCCACAGTGCCCAAAACTGAAGAC CAGCGTCCTCAGTTAGATCCTTATCAGATTCTTGGACCAACAAGTAGCCGCCTTGCAAATCCAGGCAGTGGCCAGATCCAGCTTTGGCAG TTCCTCCTGGAGCTCCTGTCGGACAGCTCCAACTCCAGCTGCATCACCTGGGAAGGCACCAACGGGGAGTTCAAGATGACGGATCCCGAC GAGGTGGCCCGGCGCTGGGGAGAGCGGAAGAGCAAACCCAACATGAACTACGATAAGCTCAGCCGCGCCCTCCGTTACTACTATGACAAG AACATCATGACCAAGGTCCATGGGAAGCGCTACGCCTACAAGTTCGACTTCCACGGGATCGCCCAGGCCCTCCAGCCCCACCCCCCGGAG TCATCTCTGTACAAGTACCCCTCAGACCTCCCGTACATGGGCTCCTATCACGCCCACCCACAGAAGATGAACTTTGTGGCGCCCCACCCT CCAGCCCTCCCCGTGACATCTTCCAGTTTTTTTGCTGCCCCAAACCCATACTGGAATTCACCAACTGGGGGTATATACCCCAACACTAGG CTCCCCACCAGCCATATGCCTTCTCATCTGGGCACTTACTACTAAAGACCTGGCGGAGGCTTTTCCCATCAGCGTGCATTCACCAGCCCA TCGCCACAAACTCTATCGGAGAACATGAATCAAAAGTGCCTCAAGAGGAATGAAAAAAGCTTTACTGGGGCTGGGGAAGGAAGCCGGGGA AGAGATCCAAAGACTCTTGGGAGGGAGTTACTGAAGTCTTACTACAGAAATGAGGAGGATGCTAAAAATGTCACGAATATGGACATATCA TCTGTGGACTGACCTTGTAAAAGACAGTGTATGTAGAAGCATGAAGTCTTAAGGACAAAGTGCCAAAGAAAGTGGTCTTAAGAAATGTAT AAACTTTAGAGTAGAGTTTGGAATCCCACTAATGCAAACTGGGATGAAACTAAAGCAATAGAAACAACACAGTTTTGACCTAACATACCG TTTATAATGCCATTTTAAGGAAAACTACCTGTATTTAAAAATAGAAACATATCAAAAACAAGAGAAAAGACACGAGAGAGACTGTGGCCC ATCAACAGACGTTGATATGCAACTGCATGGCATGTGCTGTTTTGGTTGAAATCAAATACATTCCGTTTGATGGACAGCTGTCAGCTTTCT CAAACTGTGAAGATGACCCAAAGTTTCCAACTCCTTTACAGTATTACCGGGACTATGAACTAAAAGGTGGGACTGAGGATGTGTATAGAG TGAGCGTGTGATTGTAGACAGAGGGGTGAAGAAGGAGGAGGAAGAGGCAGAGAAGGAGGAGACCAGGGCTGGGAAAGAAACTTCTCAAGC AATGAAGACTGGACTCAGGACATTTGGGGACTGTGTACAATGAGTTATGGAGACTCGAGGGTTCATGCAGTCAGTGTTATACCAAACCCA GTGTTAGGAGAAAGGACACAGCGTAATGGAGAAAGGGGAAGTAGTAGAATTCAGAAACAAAAATGCGCATCTCTTTCTTTGTTTGTCAAA TGAAAATTTTAACTGGAATTGTCTGATATTTAAGAGAAACATTCAGGACCTCATCATTATGTGGGGGCTTTGTTCTCCACAGGGTCAGGT AAGAGATGGCCTTCTTGGCTGCCACAATCAGAAATCACGCAGGCATTTTGGGTAGGCGGCCTCCAGTTTTCCTTTGAGTCGCGAACGCTG TGCGTTTGTCAGAATGAAGTATACAAGTCAATGTTTTTCCCCCTTTTTATATAATAATTATATAACTTATGCATTTATACACTACGAGTT GATCTCGGCCAGCCAAAGACACACGACAAAAGAGACAATCGATATAATGTGGCCTTGAATTTTAACTCTGTATGCTTAATGTTTACAATA TGAAGTTATTAGTTCTTAGAATGCAGAATGTATGTAATAAAATAAGCTTGGCCTAGCATGGCAAATCAGATTTATACAGGAGTCTGCATT TGCACTTTTTTTAGTGACTAAAGTTGCTTAATGAAAACATGTGCTGAATGTTGTGGATTTTGTGTTATAATTTACTTTGTCCAGGAACTT GTGCAAGGGAGAGCCAAGGAAATAGGATGTTTGGCACCCAAATGGCGTCAGCCTCTCCAGGTCCTTCTTGCCTCCCCTCCTGTCTTTTAT TTCTAGCCCCTTTTGGAACAGAAGGACCCCGGGTTTCACATTGGAGCCTCCATATTTATGCCTGGAATGGAAAGAGGCCTATGAAGCTGG GGTTGTCATTGAGAAATTCTAGTTCAGCACCTGGTCACAAATCACCCTTAATTCCTGCTATGATTAAAATACATTTGTTGAACAGTGAAC AAGCTACCACTCGTAAGGCAAACTGTATTATTACTGGCAAATAAAGCGTCATGGATAGCTGCAATTTCTCACTTTACAGAAACAAGGGAT AACGTCTAGATTTGCTGCGGGGTTTCTCTTTCAGGAGCTCTCACTAGGTAGACAGCTTTAGTCCTGCTACATCAGAGTTACCTGGGCACT GTGGCTTGGGATTCACTAGCCCTGAGCCTGATGTTGCTGGCTATCCCTTGAAGACAATGTTTATTTCCATAATCTAGAGTCAGTTTCCCT GGGCATCTTTTCTTTGAATCACAAATGCTGCCAACCTTGGTCCAGGTGAAGGCAACTCAAAAGGTGAAAATACAAGGTGACCGTGCGAAG GCGCTAGCCGAAACATCTTAGCTGAATAGGTTTCTGAACTGGCCCTTTTCATAGCTGTTTCAGGGCCTGTTTTTTTCACGTTGCAGTCCT TTTGCTATGATTATGTGAAGTTGCCAAACCTCTGTGCTGTGGATGTTTTGGCAGTGGGCTTTGAAGTCGGCAGGACACGATTACCAATGC TCCTGACACCCCGTGTCATTTGGATTAGACGGAGCCCAACCATCCATCATTTTGCAGCAGCCTGGGAAGGCCCACAAAGTGCCCGTATCT CCTTAGGGAAAATAAATAAATACAATCATGAAAGCTGGCAGTTAGGCTGACCCAAACTGTGCTAATGGAAAAGATCAGTCATTTTTATTT TGGAATGCAAAGTCAAGACACACCTACATTCTTCATAGAAATACACATTTACTTGGATAATCACTCAGTTCTCTCTTCAAGACTGTCTCA TGAGCAAGATCATAAAAACAAGACATGATTATCATATTCAATTTTAACAGATGTTTTCCATTAGATCCCTCAACCCTCCACCCCCAGTCC AGGTTATTAGCAAGTCTTATGAGCAACTGGGATAATTTTGGATAACATGATAATACTGAGTTCCTTCAAATACATAATTCTTAAATTGTT TCAAAATGGCATTAACTCTCTGTTACTGTTGTAATCTAATTCCAAAGCCCCCTCCAGGTCATATTCATAATTGCATGAACCTTTTCTCTC TGTTTGTCCCTGTCTCTTGGCTTGCCCTGATGTATACTCAGACTCCTGTACAATCTTACTCCTGCTGGCAAGAGATTTGTCTTCTTTTCT TGTCTTCAATTGGCTTTCGGGCCTTGTATGTGGTAAAATCACCAAATCACAGTCAAGACTGTGTTTTTGTTCCTAGTTTGATGCCCTTAT GTCCCGGAGGGGTTCACAAAGTGCTTTGTCAGGACTGCTGCAGTTAGAAGGCTCACTGCTTCTCCTAAGCCTTCTGCACAGATGTGGCAC CTGCAACCCAGGAGCAGGAGCCGGAGGAGCTGCCCTCTGACAGCAGGTGCAGCAGAGATGGCTACAGCTCAGGAGCTGGGAAGGTGATGG GGCACAGGGAAAGCACAGATGTTCTGCAGCGCCCCAAAGTGACCCATTGCCTGGAGAAAGAGAAGAAAATATTTTTTAAAAAGCTAGTTT ATTTAGCTTCTCATTAATTCATTCAAATAAAGTCGTGAGGTGACTAATTAGAGAATAAAAATTACTTTGGACTACTCAAAAATACACCAA >In-frame_ENST00000333781_ENST00000288319_TCGA-3E-AAAY-01A_WRB_chr21_40752412_+_ERG_chr21_39817544_length(amino acids)=540AA_start in transcript=42_stop in transcript=1664 MGRLASPRRRGRRCCCGPHGAAVADPAQPGASGMSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFEALSVVSEDQSLFECAYGTPHLA KTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMT TNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVD KALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPT SSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYK FDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY -------------------------------------------------------------- >In-frame_ENST00000541890_ENST00000398907_TCGA-3E-AAAY-01A_WRB_chr21_40752412_+_ERG_chr21_39817544_length(transcript)=4862nt_BP=133nt AGCGGACCCAGCACAGCCAGGAGCGTCCGGGATGAGCTCAGCCGCGGCCGACCACTGGGCGTGGTTGCTGGTGCTCAGCTTCGTGTTTGG ATGCAATGTTCTTAGGATCCTCCTCCCGTCCTTCTCATCCTTCGAAGCCTTATCAGTTGTGAGTGAGGACCAGTCGTTGTTTGAGTGTGC CTACGGAACGCCACACCTGGCTAAGACAGAGATGACCGCGTCCTCCTCCAGCGACTATGGACAGACTTCCAAGATGAGCCCACGCGTCCC TCAGCAGGATTGGCTGTCTCAACCCCCAGCCAGGGTCACCATCAAAATGGAATGTAACCCTAGCCAGGTGAATGGCTCAAGGAACTCTCC TGATGAATGCAGTGTGGCCAAAGGCGGGAAGATGGTGGGCAGCCCAGACACCGTTGGGATGAACTACGGCAGCTACATGGAGGAGAAGCA CATGCCACCCCCAAACATGACCACGAACGAGCGCAGAGTTATCGTGCCAGCAGATCCTACGCTATGGAGTACAGACCATGTGCGGCAGTG GCTGGAGTGGGCGGTGAAAGAATATGGCCTTCCAGACGTCAACATCTTGTTATTCCAGAACATCGATGGGAAGGAACTGTGCAAGATGAC CAAGGACGACTTCCAGAGGCTCACCCCCAGCTACAACGCCGACATCCTTCTCTCACATCTCCACTACCTCAGAGAGACTCCTCTTCCACA TTTGACTTCAGATGATGTTGATAAAGCCTTACAAAACTCTCCACGGTTAATGCATGCTAGAAACACAGGGGGTGCAGCTTTTATTTTCCC AAATACTTCAGTATATCCTGAAGCTACGCAAAGAATTACAACTAGGCCAGCTGCTCAACCATCTCCTTCCACAGTGCCCAAAACTGAAGA CCAGCGTCCTCAGTTAGATCCTTATCAGATTCTTGGACCAACAAGTAGCCGCCTTGCAAATCCAGGCAGTGGCCAGATCCAGCTTTGGCA GTTCCTCCTGGAGCTCCTGTCGGACAGCTCCAACTCCAGCTGCATCACCTGGGAAGGCACCAACGGGGAGTTCAAGATGACGGATCCCGA CGAGGTGGCCCGGCGCTGGGGAGAGCGGAAGAGCAAACCCAACATGAACTACGATAAGCTCAGCCGCGCCCTCCGTTACTACTATGACAA GAACATCATGACCAAGGTCCATGGGAAGCGCTACGCCTACAAGTTCGACTTCCACGGGATCGCCCAGGCCCTCCAGCCCCACCCCCCGGA GTCATCTCTGTACAAGTACCCCTCAGACCTCCCGTACATGGGCTCCTATCACGCCCACCCACAGAAGATGAACTTTGTGGCGCCCCACCC TCCAGCCCTCCCCGTGACATCTTCCAGTTTTTTTGCTGCCCCAAACCCATACTGGAATTCACCAACTGGGGGTATATACCCCAACACTAG GCTCCCCACCAGCCATATGCCTTCTCATCTGGGCACTTACTACTAAAGACCTGGCGGAGGCTTTTCCCATCAGCGTGCATTCACCAGCCC ATCGCCACAAACTCTATCGGAGAACATGAATCAAAAGTGCCTCAAGAGGAATGAAAAAAGCTTTACTGGGGCTGGGGAAGGAAGCCGGGG AAGAGATCCAAAGACTCTTGGGAGGGAGTTACTGAAGTCTTACTACAGAAATGAGGAGGATGCTAAAAATGTCACGAATATGGACATATC ATCTGTGGACTGACCTTGTAAAAGACAGTGTATGTAGAAGCATGAAGTCTTAAGGACAAAGTGCCAAAGAAAGTGGTCTTAAGAAATGTA TAAACTTTAGAGTAGAGTTTGGAATCCCACTAATGCAAACTGGGATGAAACTAAAGCAATAGAAACAACACAGTTTTGACCTAACATACC GTTTATAATGCCATTTTAAGGAAAACTACCTGTATTTAAAAATAGAAACATATCAAAAACAAGAGAAAAGACACGAGAGAGACTGTGGCC CATCAACAGACGTTGATATGCAACTGCATGGCATGTGCTGTTTTGGTTGAAATCAAATACATTCCGTTTGATGGACAGCTGTCAGCTTTC TCAAACTGTGAAGATGACCCAAAGTTTCCAACTCCTTTACAGTATTACCGGGACTATGAACTAAAAGGTGGGACTGAGGATGTGTATAGA GTGAGCGTGTGATTGTAGACAGAGGGGTGAAGAAGGAGGAGGAAGAGGCAGAGAAGGAGGAGACCAGGGCTGGGAAAGAAACTTCTCAAG CAATGAAGACTGGACTCAGGACATTTGGGGACTGTGTACAATGAGTTATGGAGACTCGAGGGTTCATGCAGTCAGTGTTATACCAAACCC AGTGTTAGGAGAAAGGACACAGCGTAATGGAGAAAGGGGAAGTAGTAGAATTCAGAAACAAAAATGCGCATCTCTTTCTTTGTTTGTCAA ATGAAAATTTTAACTGGAATTGTCTGATATTTAAGAGAAACATTCAGGACCTCATCATTATGTGGGGGCTTTGTTCTCCACAGGGTCAGG TAAGAGATGGCCTTCTTGGCTGCCACAATCAGAAATCACGCAGGCATTTTGGGTAGGCGGCCTCCAGTTTTCCTTTGAGTCGCGAACGCT GTGCGTTTGTCAGAATGAAGTATACAAGTCAATGTTTTTCCCCCTTTTTATATAATAATTATATAACTTATGCATTTATACACTACGAGT TGATCTCGGCCAGCCAAAGACACACGACAAAAGAGACAATCGATATAATGTGGCCTTGAATTTTAACTCTGTATGCTTAATGTTTACAAT ATGAAGTTATTAGTTCTTAGAATGCAGAATGTATGTAATAAAATAAGCTTGGCCTAGCATGGCAAATCAGATTTATACAGGAGTCTGCAT TTGCACTTTTTTTAGTGACTAAAGTTGCTTAATGAAAACATGTGCTGAATGTTGTGGATTTTGTGTTATAATTTACTTTGTCCAGGAACT TGTGCAAGGGAGAGCCAAGGAAATAGGATGTTTGGCACCCAAATGGCGTCAGCCTCTCCAGGTCCTTCTTGCCTCCCCTCCTGTCTTTTA TTTCTAGCCCCTTTTGGAACAGAAGGACCCCGGGTTTCACATTGGAGCCTCCATATTTATGCCTGGAATGGAAAGAGGCCTATGAAGCTG GGGTTGTCATTGAGAAATTCTAGTTCAGCACCTGGTCACAAATCACCCTTAATTCCTGCTATGATTAAAATACATTTGTTGAACAGTGAA CAAGCTACCACTCGTAAGGCAAACTGTATTATTACTGGCAAATAAAGCGTCATGGATAGCTGCAATTTCTCACTTTACAGAAACAAGGGA TAACGTCTAGATTTGCTGCGGGGTTTCTCTTTCAGGAGCTCTCACTAGGTAGACAGCTTTAGTCCTGCTACATCAGAGTTACCTGGGCAC TGTGGCTTGGGATTCACTAGCCCTGAGCCTGATGTTGCTGGCTATCCCTTGAAGACAATGTTTATTTCCATAATCTAGAGTCAGTTTCCC TGGGCATCTTTTCTTTGAATCACAAATGCTGCCAACCTTGGTCCAGGTGAAGGCAACTCAAAAGGTGAAAATACAAGGTGACCGTGCGAA GGCGCTAGCCGAAACATCTTAGCTGAATAGGTTTCTGAACTGGCCCTTTTCATAGCTGTTTCAGGGCCTGTTTTTTTCACGTTGCAGTCC TTTTGCTATGATTATGTGAAGTTGCCAAACCTCTGTGCTGTGGATGTTTTGGCAGTGGGCTTTGAAGTCGGCAGGACACGATTACCAATG CTCCTGACACCCCGTGTCATTTGGATTAGACGGAGCCCAACCATCCATCATTTTGCAGCAGCCTGGGAAGGCCCACAAAGTGCCCGTATC TCCTTAGGGAAAATAAATAAATACAATCATGAAAGCTGGCAGTTAGGCTGACCCAAACTGTGCTAATGGAAAAGATCAGTCATTTTTATT TTGGAATGCAAAGTCAAGACACACCTACATTCTTCATAGAAATACACATTTACTTGGATAATCACTCAGTTCTCTCTTCAAGACTGTCTC ATGAGCAAGATCATAAAAACAAGACATGATTATCATATTCAATTTTAACAGATGTTTTCCATTAGATCCCTCAACCCTCCACCCCCAGTC CAGGTTATTAGCAAGTCTTATGAGCAACTGGGATAATTTTGGATAACATGATAATACTGAGTTCCTTCAAATACATAATTCTTAAATTGT TTCAAAATGGCATTAACTCTCTGTTACTGTTGTAATCTAATTCCAAAGCCCCCTCCAGGTCATATTCATAATTGCATGAACCTTTTCTCT CTGTTTGTCCCTGTCTCTTGGCTTGCCCTGATGTATACTCAGACTCCTGTACAATCTTACTCCTGCTGGCAAGAGATTTGTCTTCTTTTC TTGTCTTCAATTGGCTTTCGGGCCTTGTATGTGGTAAAATCACCAAATCACAGTCAAGACTGTGTTTTTGTTCCTAGTTTGATGCCCTTA TGTCCCGGAGGGGTTCACAAAGTGCTTTGTCAGGACTGCTGCAGTTAGAAGGCTCACTGCTTCTCCTAAGCCTTCTGCACAGATGTGGCA CCTGCAACCCAGGAGCAGGAGCCGGAGGAGCTGCCCTCTGACAGCAGGTGCAGCAGAGATGGCTACAGCTCAGGAGCTGGGAAGGTGATG GGGCACAGGGAAAGCACAGATGTTCTGCAGCGCCCCAAAGTGACCCATTGCCTGGAGAAAGAGAAGAAAATATTTTTTAAAAAGCTAGTT TATTTAGCTTCTCATTAATTCATTCAAATAAAGTCGTGAGGTGACTAATTAGAGAATAAAAATTACTTTGGACTACTCAAAAATACACCA >In-frame_ENST00000541890_ENST00000398907_TCGA-3E-AAAY-01A_WRB_chr21_40752412_+_ERG_chr21_39817544_length(amino acids)=484AA_start in transcript=31_stop in transcript=1485 MSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPA RVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGL PDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQ RITTRPAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERK SKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSF -------------------------------------------------------------- >In-frame_ENST00000541890_ENST00000398905_TCGA-3E-AAAY-01A_WRB_chr21_40752412_+_ERG_chr21_39817544_length(transcript)=4859nt_BP=133nt AGCGGACCCAGCACAGCCAGGAGCGTCCGGGATGAGCTCAGCCGCGGCCGACCACTGGGCGTGGTTGCTGGTGCTCAGCTTCGTGTTTGG ATGCAATGTTCTTAGGATCCTCCTCCCGTCCTTCTCATCCTTCGAAGCCTTATCAGTTGTGAGTGAGGACCAGTCGTTGTTTGAGTGTGC CTACGGAACGCCACACCTGGCTAAGACAGAGATGACCGCGTCCTCCTCCAGCGACTATGGACAGACTTCCAAGATGAGCCCACGCGTCCC TCAGCAGGATTGGCTGTCTCAACCCCCAGCCAGGGTCACCATCAAAATGGAATGTAACCCTAGCCAGGTGAATGGCTCAAGGAACTCTCC TGATGAATGCAGTGTGGCCAAAGGCGGGAAGATGGTGGGCAGCCCAGACACCGTTGGGATGAACTACGGCAGCTACATGGAGGAGAAGCA CATGCCACCCCCAAACATGACCACGAACGAGCGCAGAGTTATCGTGCCAGCAGATCCTACGCTATGGAGTACAGACCATGTGCGGCAGTG GCTGGAGTGGGCGGTGAAAGAATATGGCCTTCCAGACGTCAACATCTTGTTATTCCAGAACATCGATGGGAAGGAACTGTGCAAGATGAC CAAGGACGACTTCCAGAGGCTCACCCCCAGCTACAACGCCGACATCCTTCTCTCACATCTCCACTACCTCAGAGAGACTCCTCTTCCACA TTTGACTTCAGATGATGTTGATAAAGCCTTACAAAACTCTCCACGGTTAATGCATGCTAGAAACACAGATTTACCATATGAGCCCCCCAG GAGATCAGCCTGGACCGGTCACGGCCACCCCACGCCCCAGTCGAAAGCTGCTCAACCATCTCCTTCCACAGTGCCCAAAACTGAAGACCA GCGTCCTCAGTTAGATCCTTATCAGATTCTTGGACCAACAAGTAGCCGCCTTGCAAATCCAGGCAGTGGCCAGATCCAGCTTTGGCAGTT CCTCCTGGAGCTCCTGTCGGACAGCTCCAACTCCAGCTGCATCACCTGGGAAGGCACCAACGGGGAGTTCAAGATGACGGATCCCGACGA GGTGGCCCGGCGCTGGGGAGAGCGGAAGAGCAAACCCAACATGAACTACGATAAGCTCAGCCGCGCCCTCCGTTACTACTATGACAAGAA CATCATGACCAAGGTCCATGGGAAGCGCTACGCCTACAAGTTCGACTTCCACGGGATCGCCCAGGCCCTCCAGCCCCACCCCCCGGAGTC ATCTCTGTACAAGTACCCCTCAGACCTCCCGTACATGGGCTCCTATCACGCCCACCCACAGAAGATGAACTTTGTGGCGCCCCACCCTCC AGCCCTCCCCGTGACATCTTCCAGTTTTTTTGCTGCCCCAAACCCATACTGGAATTCACCAACTGGGGGTATATACCCCAACACTAGGCT CCCCACCAGCCATATGCCTTCTCATCTGGGCACTTACTACTAAAGACCTGGCGGAGGCTTTTCCCATCAGCGTGCATTCACCAGCCCATC GCCACAAACTCTATCGGAGAACATGAATCAAAAGTGCCTCAAGAGGAATGAAAAAAGCTTTACTGGGGCTGGGGAAGGAAGCCGGGGAAG AGATCCAAAGACTCTTGGGAGGGAGTTACTGAAGTCTTACTACAGAAATGAGGAGGATGCTAAAAATGTCACGAATATGGACATATCATC TGTGGACTGACCTTGTAAAAGACAGTGTATGTAGAAGCATGAAGTCTTAAGGACAAAGTGCCAAAGAAAGTGGTCTTAAGAAATGTATAA ACTTTAGAGTAGAGTTTGGAATCCCACTAATGCAAACTGGGATGAAACTAAAGCAATAGAAACAACACAGTTTTGACCTAACATACCGTT TATAATGCCATTTTAAGGAAAACTACCTGTATTTAAAAATAGAAACATATCAAAAACAAGAGAAAAGACACGAGAGAGACTGTGGCCCAT CAACAGACGTTGATATGCAACTGCATGGCATGTGCTGTTTTGGTTGAAATCAAATACATTCCGTTTGATGGACAGCTGTCAGCTTTCTCA AACTGTGAAGATGACCCAAAGTTTCCAACTCCTTTACAGTATTACCGGGACTATGAACTAAAAGGTGGGACTGAGGATGTGTATAGAGTG AGCGTGTGATTGTAGACAGAGGGGTGAAGAAGGAGGAGGAAGAGGCAGAGAAGGAGGAGACCAGGGCTGGGAAAGAAACTTCTCAAGCAA TGAAGACTGGACTCAGGACATTTGGGGACTGTGTACAATGAGTTATGGAGACTCGAGGGTTCATGCAGTCAGTGTTATACCAAACCCAGT GTTAGGAGAAAGGACACAGCGTAATGGAGAAAGGGGAAGTAGTAGAATTCAGAAACAAAAATGCGCATCTCTTTCTTTGTTTGTCAAATG AAAATTTTAACTGGAATTGTCTGATATTTAAGAGAAACATTCAGGACCTCATCATTATGTGGGGGCTTTGTTCTCCACAGGGTCAGGTAA GAGATGGCCTTCTTGGCTGCCACAATCAGAAATCACGCAGGCATTTTGGGTAGGCGGCCTCCAGTTTTCCTTTGAGTCGCGAACGCTGTG CGTTTGTCAGAATGAAGTATACAAGTCAATGTTTTTCCCCCTTTTTATATAATAATTATATAACTTATGCATTTATACACTACGAGTTGA TCTCGGCCAGCCAAAGACACACGACAAAAGAGACAATCGATATAATGTGGCCTTGAATTTTAACTCTGTATGCTTAATGTTTACAATATG AAGTTATTAGTTCTTAGAATGCAGAATGTATGTAATAAAATAAGCTTGGCCTAGCATGGCAAATCAGATTTATACAGGAGTCTGCATTTG CACTTTTTTTAGTGACTAAAGTTGCTTAATGAAAACATGTGCTGAATGTTGTGGATTTTGTGTTATAATTTACTTTGTCCAGGAACTTGT GCAAGGGAGAGCCAAGGAAATAGGATGTTTGGCACCCAAATGGCGTCAGCCTCTCCAGGTCCTTCTTGCCTCCCCTCCTGTCTTTTATTT CTAGCCCCTTTTGGAACAGAAGGACCCCGGGTTTCACATTGGAGCCTCCATATTTATGCCTGGAATGGAAAGAGGCCTATGAAGCTGGGG TTGTCATTGAGAAATTCTAGTTCAGCACCTGGTCACAAATCACCCTTAATTCCTGCTATGATTAAAATACATTTGTTGAACAGTGAACAA GCTACCACTCGTAAGGCAAACTGTATTATTACTGGCAAATAAAGCGTCATGGATAGCTGCAATTTCTCACTTTACAGAAACAAGGGATAA CGTCTAGATTTGCTGCGGGGTTTCTCTTTCAGGAGCTCTCACTAGGTAGACAGCTTTAGTCCTGCTACATCAGAGTTACCTGGGCACTGT GGCTTGGGATTCACTAGCCCTGAGCCTGATGTTGCTGGCTATCCCTTGAAGACAATGTTTATTTCCATAATCTAGAGTCAGTTTCCCTGG GCATCTTTTCTTTGAATCACAAATGCTGCCAACCTTGGTCCAGGTGAAGGCAACTCAAAAGGTGAAAATACAAGGTGACCGTGCGAAGGC GCTAGCCGAAACATCTTAGCTGAATAGGTTTCTGAACTGGCCCTTTTCATAGCTGTTTCAGGGCCTGTTTTTTTCACGTTGCAGTCCTTT TGCTATGATTATGTGAAGTTGCCAAACCTCTGTGCTGTGGATGTTTTGGCAGTGGGCTTTGAAGTCGGCAGGACACGATTACCAATGCTC CTGACACCCCGTGTCATTTGGATTAGACGGAGCCCAACCATCCATCATTTTGCAGCAGCCTGGGAAGGCCCACAAAGTGCCCGTATCTCC TTAGGGAAAATAAATAAATACAATCATGAAAGCTGGCAGTTAGGCTGACCCAAACTGTGCTAATGGAAAAGATCAGTCATTTTTATTTTG GAATGCAAAGTCAAGACACACCTACATTCTTCATAGAAATACACATTTACTTGGATAATCACTCAGTTCTCTCTTCAAGACTGTCTCATG AGCAAGATCATAAAAACAAGACATGATTATCATATTCAATTTTAACAGATGTTTTCCATTAGATCCCTCAACCCTCCACCCCCAGTCCAG GTTATTAGCAAGTCTTATGAGCAACTGGGATAATTTTGGATAACATGATAATACTGAGTTCCTTCAAATACATAATTCTTAAATTGTTTC AAAATGGCATTAACTCTCTGTTACTGTTGTAATCTAATTCCAAAGCCCCCTCCAGGTCATATTCATAATTGCATGAACCTTTTCTCTCTG TTTGTCCCTGTCTCTTGGCTTGCCCTGATGTATACTCAGACTCCTGTACAATCTTACTCCTGCTGGCAAGAGATTTGTCTTCTTTTCTTG TCTTCAATTGGCTTTCGGGCCTTGTATGTGGTAAAATCACCAAATCACAGTCAAGACTGTGTTTTTGTTCCTAGTTTGATGCCCTTATGT CCCGGAGGGGTTCACAAAGTGCTTTGTCAGGACTGCTGCAGTTAGAAGGCTCACTGCTTCTCCTAAGCCTTCTGCACAGATGTGGCACCT GCAACCCAGGAGCAGGAGCCGGAGGAGCTGCCCTCTGACAGCAGGTGCAGCAGAGATGGCTACAGCTCAGGAGCTGGGAAGGTGATGGGG CACAGGGAAAGCACAGATGTTCTGCAGCGCCCCAAAGTGACCCATTGCCTGGAGAAAGAGAAGAAAATATTTTTTAAAAAGCTAGTTTAT >In-frame_ENST00000541890_ENST00000398905_TCGA-3E-AAAY-01A_WRB_chr21_40752412_+_ERG_chr21_39817544_length(amino acids)=483AA_start in transcript=31_stop in transcript=1482 MSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPA RVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGL PDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHP TPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKS KPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFF -------------------------------------------------------------- >In-frame_ENST00000541890_ENST00000288319_TCGA-3E-AAAY-01A_WRB_chr21_40752412_+_ERG_chr21_39817544_length(transcript)=4931nt_BP=133nt AGCGGACCCAGCACAGCCAGGAGCGTCCGGGATGAGCTCAGCCGCGGCCGACCACTGGGCGTGGTTGCTGGTGCTCAGCTTCGTGTTTGG ATGCAATGTTCTTAGGATCCTCCTCCCGTCCTTCTCATCCTTCGAAGCCTTATCAGTTGTGAGTGAGGACCAGTCGTTGTTTGAGTGTGC CTACGGAACGCCACACCTGGCTAAGACAGAGATGACCGCGTCCTCCTCCAGCGACTATGGACAGACTTCCAAGATGAGCCCACGCGTCCC TCAGCAGGATTGGCTGTCTCAACCCCCAGCCAGGGTCACCATCAAAATGGAATGTAACCCTAGCCAGGTGAATGGCTCAAGGAACTCTCC TGATGAATGCAGTGTGGCCAAAGGCGGGAAGATGGTGGGCAGCCCAGACACCGTTGGGATGAACTACGGCAGCTACATGGAGGAGAAGCA CATGCCACCCCCAAACATGACCACGAACGAGCGCAGAGTTATCGTGCCAGCAGATCCTACGCTATGGAGTACAGACCATGTGCGGCAGTG GCTGGAGTGGGCGGTGAAAGAATATGGCCTTCCAGACGTCAACATCTTGTTATTCCAGAACATCGATGGGAAGGAACTGTGCAAGATGAC CAAGGACGACTTCCAGAGGCTCACCCCCAGCTACAACGCCGACATCCTTCTCTCACATCTCCACTACCTCAGAGAGACTCCTCTTCCACA TTTGACTTCAGATGATGTTGATAAAGCCTTACAAAACTCTCCACGGTTAATGCATGCTAGAAACACAGGGGGTGCAGCTTTTATTTTCCC AAATACTTCAGTATATCCTGAAGCTACGCAAAGAATTACAACTAGGCCAGATTTACCATATGAGCCCCCCAGGAGATCAGCCTGGACCGG TCACGGCCACCCCACGCCCCAGTCGAAAGCTGCTCAACCATCTCCTTCCACAGTGCCCAAAACTGAAGACCAGCGTCCTCAGTTAGATCC TTATCAGATTCTTGGACCAACAAGTAGCCGCCTTGCAAATCCAGGCAGTGGCCAGATCCAGCTTTGGCAGTTCCTCCTGGAGCTCCTGTC GGACAGCTCCAACTCCAGCTGCATCACCTGGGAAGGCACCAACGGGGAGTTCAAGATGACGGATCCCGACGAGGTGGCCCGGCGCTGGGG AGAGCGGAAGAGCAAACCCAACATGAACTACGATAAGCTCAGCCGCGCCCTCCGTTACTACTATGACAAGAACATCATGACCAAGGTCCA TGGGAAGCGCTACGCCTACAAGTTCGACTTCCACGGGATCGCCCAGGCCCTCCAGCCCCACCCCCCGGAGTCATCTCTGTACAAGTACCC CTCAGACCTCCCGTACATGGGCTCCTATCACGCCCACCCACAGAAGATGAACTTTGTGGCGCCCCACCCTCCAGCCCTCCCCGTGACATC TTCCAGTTTTTTTGCTGCCCCAAACCCATACTGGAATTCACCAACTGGGGGTATATACCCCAACACTAGGCTCCCCACCAGCCATATGCC TTCTCATCTGGGCACTTACTACTAAAGACCTGGCGGAGGCTTTTCCCATCAGCGTGCATTCACCAGCCCATCGCCACAAACTCTATCGGA GAACATGAATCAAAAGTGCCTCAAGAGGAATGAAAAAAGCTTTACTGGGGCTGGGGAAGGAAGCCGGGGAAGAGATCCAAAGACTCTTGG GAGGGAGTTACTGAAGTCTTACTACAGAAATGAGGAGGATGCTAAAAATGTCACGAATATGGACATATCATCTGTGGACTGACCTTGTAA AAGACAGTGTATGTAGAAGCATGAAGTCTTAAGGACAAAGTGCCAAAGAAAGTGGTCTTAAGAAATGTATAAACTTTAGAGTAGAGTTTG GAATCCCACTAATGCAAACTGGGATGAAACTAAAGCAATAGAAACAACACAGTTTTGACCTAACATACCGTTTATAATGCCATTTTAAGG AAAACTACCTGTATTTAAAAATAGAAACATATCAAAAACAAGAGAAAAGACACGAGAGAGACTGTGGCCCATCAACAGACGTTGATATGC AACTGCATGGCATGTGCTGTTTTGGTTGAAATCAAATACATTCCGTTTGATGGACAGCTGTCAGCTTTCTCAAACTGTGAAGATGACCCA AAGTTTCCAACTCCTTTACAGTATTACCGGGACTATGAACTAAAAGGTGGGACTGAGGATGTGTATAGAGTGAGCGTGTGATTGTAGACA GAGGGGTGAAGAAGGAGGAGGAAGAGGCAGAGAAGGAGGAGACCAGGGCTGGGAAAGAAACTTCTCAAGCAATGAAGACTGGACTCAGGA CATTTGGGGACTGTGTACAATGAGTTATGGAGACTCGAGGGTTCATGCAGTCAGTGTTATACCAAACCCAGTGTTAGGAGAAAGGACACA GCGTAATGGAGAAAGGGGAAGTAGTAGAATTCAGAAACAAAAATGCGCATCTCTTTCTTTGTTTGTCAAATGAAAATTTTAACTGGAATT GTCTGATATTTAAGAGAAACATTCAGGACCTCATCATTATGTGGGGGCTTTGTTCTCCACAGGGTCAGGTAAGAGATGGCCTTCTTGGCT GCCACAATCAGAAATCACGCAGGCATTTTGGGTAGGCGGCCTCCAGTTTTCCTTTGAGTCGCGAACGCTGTGCGTTTGTCAGAATGAAGT ATACAAGTCAATGTTTTTCCCCCTTTTTATATAATAATTATATAACTTATGCATTTATACACTACGAGTTGATCTCGGCCAGCCAAAGAC ACACGACAAAAGAGACAATCGATATAATGTGGCCTTGAATTTTAACTCTGTATGCTTAATGTTTACAATATGAAGTTATTAGTTCTTAGA ATGCAGAATGTATGTAATAAAATAAGCTTGGCCTAGCATGGCAAATCAGATTTATACAGGAGTCTGCATTTGCACTTTTTTTAGTGACTA AAGTTGCTTAATGAAAACATGTGCTGAATGTTGTGGATTTTGTGTTATAATTTACTTTGTCCAGGAACTTGTGCAAGGGAGAGCCAAGGA AATAGGATGTTTGGCACCCAAATGGCGTCAGCCTCTCCAGGTCCTTCTTGCCTCCCCTCCTGTCTTTTATTTCTAGCCCCTTTTGGAACA GAAGGACCCCGGGTTTCACATTGGAGCCTCCATATTTATGCCTGGAATGGAAAGAGGCCTATGAAGCTGGGGTTGTCATTGAGAAATTCT AGTTCAGCACCTGGTCACAAATCACCCTTAATTCCTGCTATGATTAAAATACATTTGTTGAACAGTGAACAAGCTACCACTCGTAAGGCA AACTGTATTATTACTGGCAAATAAAGCGTCATGGATAGCTGCAATTTCTCACTTTACAGAAACAAGGGATAACGTCTAGATTTGCTGCGG GGTTTCTCTTTCAGGAGCTCTCACTAGGTAGACAGCTTTAGTCCTGCTACATCAGAGTTACCTGGGCACTGTGGCTTGGGATTCACTAGC CCTGAGCCTGATGTTGCTGGCTATCCCTTGAAGACAATGTTTATTTCCATAATCTAGAGTCAGTTTCCCTGGGCATCTTTTCTTTGAATC ACAAATGCTGCCAACCTTGGTCCAGGTGAAGGCAACTCAAAAGGTGAAAATACAAGGTGACCGTGCGAAGGCGCTAGCCGAAACATCTTA GCTGAATAGGTTTCTGAACTGGCCCTTTTCATAGCTGTTTCAGGGCCTGTTTTTTTCACGTTGCAGTCCTTTTGCTATGATTATGTGAAG TTGCCAAACCTCTGTGCTGTGGATGTTTTGGCAGTGGGCTTTGAAGTCGGCAGGACACGATTACCAATGCTCCTGACACCCCGTGTCATT TGGATTAGACGGAGCCCAACCATCCATCATTTTGCAGCAGCCTGGGAAGGCCCACAAAGTGCCCGTATCTCCTTAGGGAAAATAAATAAA TACAATCATGAAAGCTGGCAGTTAGGCTGACCCAAACTGTGCTAATGGAAAAGATCAGTCATTTTTATTTTGGAATGCAAAGTCAAGACA CACCTACATTCTTCATAGAAATACACATTTACTTGGATAATCACTCAGTTCTCTCTTCAAGACTGTCTCATGAGCAAGATCATAAAAACA AGACATGATTATCATATTCAATTTTAACAGATGTTTTCCATTAGATCCCTCAACCCTCCACCCCCAGTCCAGGTTATTAGCAAGTCTTAT GAGCAACTGGGATAATTTTGGATAACATGATAATACTGAGTTCCTTCAAATACATAATTCTTAAATTGTTTCAAAATGGCATTAACTCTC TGTTACTGTTGTAATCTAATTCCAAAGCCCCCTCCAGGTCATATTCATAATTGCATGAACCTTTTCTCTCTGTTTGTCCCTGTCTCTTGG CTTGCCCTGATGTATACTCAGACTCCTGTACAATCTTACTCCTGCTGGCAAGAGATTTGTCTTCTTTTCTTGTCTTCAATTGGCTTTCGG GCCTTGTATGTGGTAAAATCACCAAATCACAGTCAAGACTGTGTTTTTGTTCCTAGTTTGATGCCCTTATGTCCCGGAGGGGTTCACAAA GTGCTTTGTCAGGACTGCTGCAGTTAGAAGGCTCACTGCTTCTCCTAAGCCTTCTGCACAGATGTGGCACCTGCAACCCAGGAGCAGGAG CCGGAGGAGCTGCCCTCTGACAGCAGGTGCAGCAGAGATGGCTACAGCTCAGGAGCTGGGAAGGTGATGGGGCACAGGGAAAGCACAGAT GTTCTGCAGCGCCCCAAAGTGACCCATTGCCTGGAGAAAGAGAAGAAAATATTTTTTAAAAAGCTAGTTTATTTAGCTTCTCATTAATTC >In-frame_ENST00000541890_ENST00000288319_TCGA-3E-AAAY-01A_WRB_chr21_40752412_+_ERG_chr21_39817544_length(amino acids)=507AA_start in transcript=31_stop in transcript=1554 MSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPA RVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGL PDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQ RITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITW EGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYH -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for WRB-ERG |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000333781 | + | 1 | 5 | 39_97 | 34.0 | 175.0 | GET3/TRC40 |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000380708 | + | 1 | 5 | 39_97 | 0 | 141.0 | GET3/TRC40 |
Hgene | WRB | chr21:40752412 | chr21:39817544 | ENST00000398753 | + | 1 | 5 | 39_97 | 0 | 141.0 | GET3/TRC40 |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for WRB-ERG |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for WRB-ERG |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ERG | C0033578 | Prostatic Neoplasms | 7 | CTD_human |
Tgene | ERG | C0376358 | Malignant neoplasm of prostate | 7 | CTD_human |
Tgene | ERG | C0023418 | leukemia | 1 | CTD_human |
Tgene | ERG | C0023452 | Childhood Acute Lymphoblastic Leukemia | 1 | CTD_human |
Tgene | ERG | C0023453 | L2 Acute Lymphoblastic Leukemia | 1 | CTD_human |
Tgene | ERG | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Tgene | ERG | C0026998 | Acute Myeloid Leukemia, M1 | 1 | CTD_human |
Tgene | ERG | C0279980 | Extra-osseous Ewing's sarcoma | 1 | ORPHANET |
Tgene | ERG | C1879321 | Acute Myeloid Leukemia (AML-M2) | 1 | CTD_human |
Tgene | ERG | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |