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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:XPNPEP3-RTCB (FusionGDB2 ID:98976)

Fusion Gene Summary for XPNPEP3-RTCB

check button Fusion gene summary
Fusion gene informationFusion gene name: XPNPEP3-RTCB
Fusion gene ID: 98976
HgeneTgene
Gene symbol

XPNPEP3

RTCB

Gene ID

63929

51493

Gene nameX-prolyl aminopeptidase 3RNA 2',3'-cyclic phosphate and 5'-OH ligase
SynonymsAPP3|ICP55|NPHPL1C22orf28|DJ149A16.6|FAAP|HSPC117
Cytomap

22q13.2

22q12.3

Type of geneprotein-codingprotein-coding
Descriptionxaa-Pro aminopeptidase 3Intermediate Cleaving Peptidase 55X-Pro aminopeptidase 3X-prolyl aminopeptidase 3, mitochondrialprobable Xaa-Pro aminopeptidase 3tRNA-splicing ligase RtcB homologankyrin repeat domain 54focal adhesion-associated protein
Modification date2020032020200313
UniProtAcc.

Q9Y3I0

Ensembl transtripts involved in fusion geneENST00000541156, ENST00000357137, 
ENST00000544094, ENST00000414396, 
ENST00000482652, 		ENST00000216038, 
ENST00000451746, ENST00000476619, 
Fusion gene scores* DoF score14 X 12 X 4=6724 X 4 X 3=48
# samples 145
** MAII scorelog2(14/672*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: XPNPEP3 [Title/Abstract] AND RTCB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointXPNPEP3(41282519)-RTCB(32784086), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneXPNPEP3

GO:0006508

proteolysis

28476889

TgeneRTCB

GO:0006388

tRNA splicing, via endonucleolytic cleavage and ligation

21311021|24870230


check buttonFusion gene breakpoints across XPNPEP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RTCB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-69-7761-01AXPNPEP3chr22

41282519

+RTCBchr22

32784086

-


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Fusion Gene ORF analysis for XPNPEP3-RTCB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000541156ENST00000216038XPNPEP3chr22

41282519

+RTCBchr22

32784086

-
5CDS-3UTRENST00000541156ENST00000451746XPNPEP3chr22

41282519

+RTCBchr22

32784086

-
5CDS-intronENST00000541156ENST00000476619XPNPEP3chr22

41282519

+RTCBchr22

32784086

-
In-frameENST00000357137ENST00000216038XPNPEP3chr22

41282519

+RTCBchr22

32784086

-
5CDS-3UTRENST00000357137ENST00000451746XPNPEP3chr22

41282519

+RTCBchr22

32784086

-
5CDS-intronENST00000357137ENST00000476619XPNPEP3chr22

41282519

+RTCBchr22

32784086

-
In-frameENST00000544094ENST00000216038XPNPEP3chr22

41282519

+RTCBchr22

32784086

-
5CDS-3UTRENST00000544094ENST00000451746XPNPEP3chr22

41282519

+RTCBchr22

32784086

-
5CDS-intronENST00000544094ENST00000476619XPNPEP3chr22

41282519

+RTCBchr22

32784086

-
In-frameENST00000414396ENST00000216038XPNPEP3chr22

41282519

+RTCBchr22

32784086

-
5CDS-3UTRENST00000414396ENST00000451746XPNPEP3chr22

41282519

+RTCBchr22

32784086

-
5CDS-intronENST00000414396ENST00000476619XPNPEP3chr22

41282519

+RTCBchr22

32784086

-
intron-3CDSENST00000482652ENST00000216038XPNPEP3chr22

41282519

+RTCBchr22

32784086

-
intron-3UTRENST00000482652ENST00000451746XPNPEP3chr22

41282519

+RTCBchr22

32784086

-
intron-intronENST00000482652ENST00000476619XPNPEP3chr22

41282519

+RTCBchr22

32784086

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000541156XPNPEP3chr2241282519+ENST00000216038RTCBchr2232784086-140889098997299
ENST00000357137XPNPEP3chr2241282519+ENST00000216038RTCBchr2232784086-139487684983299
ENST00000544094XPNPEP3chr2241282519+ENST00000216038RTCBchr2232784086-166111434021250282
ENST00000414396XPNPEP3chr2241282519+ENST00000216038RTCBchr2232784086-140288492991299

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000541156ENST00000216038XPNPEP3chr2241282519+RTCBchr2232784086-0.0040100480.99599
ENST00000357137ENST00000216038XPNPEP3chr2241282519+RTCBchr2232784086-0.0039121040.9960879
ENST00000544094ENST00000216038XPNPEP3chr2241282519+RTCBchr2232784086-0.0013135520.9986865
ENST00000414396ENST00000216038XPNPEP3chr2241282519+RTCBchr2232784086-0.0039342520.9960658

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Fusion Genomic Features for XPNPEP3-RTCB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for XPNPEP3-RTCB


check button Go to

FGviewer for the breakpoints of chr22:41282519-chr22:32784086

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.RTCB

Q9Y3I0

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. {ECO:0000255|HAMAP-Rule:MF_03144, ECO:0000269|PubMed:21311021, ECO:0000269|PubMed:24870230}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRTCBchr22:41282519chr22:32784086ENST000002160381012226_230470.0506.0Nucleotide bindingGMP
TgeneRTCBchr22:41282519chr22:32784086ENST000002160381012353_354470.0506.0Nucleotide bindingGMP
TgeneRTCBchr22:41282519chr22:32784086ENST000002160381012402_405470.0506.0Nucleotide bindingGMP
TgeneRTCBchr22:41282519chr22:32784086ENST000002160381012428_431470.0506.0Nucleotide bindingGMP


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Fusion Gene Sequence for XPNPEP3-RTCB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000541156_ENST00000216038_TCGA-69-7761-01A_XPNPEP3_chr22_41282519_+_RTCB_chr22_32784086_length(transcript)=1408nt_BP=890nt
GGTGCGGCTGGCCCGGTTTCCTGGCGACGCGGCCCTGCAGGCGGTTGCGTTCCCCGTCGTTACCCTCTTTCTCTTCCCGACGCGTGAGTT
AGGCCGTAATGCCTTGGCTGCTCTCAGCCCCCAAGCTGGTTCCCGCTGTAGCAAACGTCCGCGGCCTCTCAGGATGTATGTTGTGTTCAC
AGCGAAGGTACTCCCTTCAGCCTGTCCCAGAAAGGAGGATTCCAAACCGATACTTAGGCCAGCCCAGCCCCTTTACACACCCACACCTCC
TCAGACCAGGGGAGGTAACTCCAGGACTATCTCAGGTGGAATATGCACTTCGCAGACACAAACTAATGTCTCTGATCCAGAAGGAAGCTC
AAGGGCAGAGTGGGACAGACCAGACAGTGGTTGTGCTCTCCAACCCTACATACTACATGAGCAACGATATTCCCTATACTTTCCACCAAG
ACAACAATTTCCTGTACCTATGTGGATTCCAAGAGCCTGATAGCATTCTTGTCCTTCAGAGCCTCCCTGGCAAACAATTACCATCACACA
AAGCCATACTTTTTGTGCCTCGGCGAGATCCCAGTCGAGAACTTTGGGATGGTCCGCGATCTGGCACTGATGGAGCAATAGCTCTAACTG
GAGTAGACGAAGCCTATACGCTAGAAGAATTTCAACATCTTCTACCAAAAATGAAAGCTGAGACGAACATGGTTTGGTATGACTGGATGA
GGCCCTCACATGCACAGCTTCACTCTGACTATATGCAGCCCCTGACTGAGGCCAAAGCCAAGAGCAAGAACAAGGTTCGGGGTGTTCAGC
AGCTGATACAGCGCCTCCGGCTGATCAAGTCTCCTGCAGAAATTGAACGAATGCAGATTGCTGGGAAGCTGACATCACAGGCTCCTGAGT
CCTATAAGAATGTGACAGATGTGGTAAATACCTGCCATGATGCTGGAATCAGCAAGAAAGCCATTAAACTGAGACCAATTGCTGTGATCA
AAGGATAGAACCTTGGACAGCAGGGCTGCCTGACACCACCAACCCTCTCTGAAGTGGAAGTGGACTGACATGCTCTTCTGACATCAGACT
CAAGGCGGGACAAGTTGCAAAGTGTGCAGCTGTAACTGCTCACGCCAAAATGGCTGATGGGGAGGCTGCTGCTTTCAGGGGCCCGTGCTT
GTAAAATAACCTTCCAGGAAGAGGCACATTGCCCACCTTTGGAAAGGGAGGAATATGCCTTCTCCTTGGTTGTTCCACAGAGTTTTAGGA
AAATCTGTTAGGGATGGGTAGATGTCAAACTGCCTTACGCAGTCATACTGATCTTTAGCCATCAGATTGATCTTCTTCACACCAAGCTCT

>In-frame_ENST00000541156_ENST00000216038_TCGA-69-7761-01A_XPNPEP3_chr22_41282519_+_RTCB_chr22_32784086_length(amino acids)=299AA_start in transcript=98_stop in transcript=997
MPWLLSAPKLVPAVANVRGLSGCMLCSQRRYSLQPVPERRIPNRYLGQPSPFTHPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQGQ
SGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVD
EAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAPESYK

--------------------------------------------------------------
>In-frame_ENST00000357137_ENST00000216038_TCGA-69-7761-01A_XPNPEP3_chr22_41282519_+_RTCB_chr22_32784086_length(transcript)=1394nt_BP=876nt
GGTTTCCTGGCGACGCGGCCCTGCAGGCGGTTGCGTTCCCCGTCGTTACCCTCTTTCTCTTCCCGACGCGTGAGTTAGGCCGTAATGCCT
TGGCTGCTCTCAGCCCCCAAGCTGGTTCCCGCTGTAGCAAACGTCCGCGGCCTCTCAGGATGTATGTTGTGTTCACAGCGAAGGTACTCC
CTTCAGCCTGTCCCAGAAAGGAGGATTCCAAACCGATACTTAGGCCAGCCCAGCCCCTTTACACACCCACACCTCCTCAGACCAGGGGAG
GTAACTCCAGGACTATCTCAGGTGGAATATGCACTTCGCAGACACAAACTAATGTCTCTGATCCAGAAGGAAGCTCAAGGGCAGAGTGGG
ACAGACCAGACAGTGGTTGTGCTCTCCAACCCTACATACTACATGAGCAACGATATTCCCTATACTTTCCACCAAGACAACAATTTCCTG
TACCTATGTGGATTCCAAGAGCCTGATAGCATTCTTGTCCTTCAGAGCCTCCCTGGCAAACAATTACCATCACACAAAGCCATACTTTTT
GTGCCTCGGCGAGATCCCAGTCGAGAACTTTGGGATGGTCCGCGATCTGGCACTGATGGAGCAATAGCTCTAACTGGAGTAGACGAAGCC
TATACGCTAGAAGAATTTCAACATCTTCTACCAAAAATGAAAGCTGAGACGAACATGGTTTGGTATGACTGGATGAGGCCCTCACATGCA
CAGCTTCACTCTGACTATATGCAGCCCCTGACTGAGGCCAAAGCCAAGAGCAAGAACAAGGTTCGGGGTGTTCAGCAGCTGATACAGCGC
CTCCGGCTGATCAAGTCTCCTGCAGAAATTGAACGAATGCAGATTGCTGGGAAGCTGACATCACAGGCTCCTGAGTCCTATAAGAATGTG
ACAGATGTGGTAAATACCTGCCATGATGCTGGAATCAGCAAGAAAGCCATTAAACTGAGACCAATTGCTGTGATCAAAGGATAGAACCTT
GGACAGCAGGGCTGCCTGACACCACCAACCCTCTCTGAAGTGGAAGTGGACTGACATGCTCTTCTGACATCAGACTCAAGGCGGGACAAG
TTGCAAAGTGTGCAGCTGTAACTGCTCACGCCAAAATGGCTGATGGGGAGGCTGCTGCTTTCAGGGGCCCGTGCTTGTAAAATAACCTTC
CAGGAAGAGGCACATTGCCCACCTTTGGAAAGGGAGGAATATGCCTTCTCCTTGGTTGTTCCACAGAGTTTTAGGAAAATCTGTTAGGGA
TGGGTAGATGTCAAACTGCCTTACGCAGTCATACTGATCTTTAGCCATCAGATTGATCTTCTTCACACCAAGCTCTGTTTACATTCCGAG

>In-frame_ENST00000357137_ENST00000216038_TCGA-69-7761-01A_XPNPEP3_chr22_41282519_+_RTCB_chr22_32784086_length(amino acids)=299AA_start in transcript=84_stop in transcript=983
MPWLLSAPKLVPAVANVRGLSGCMLCSQRRYSLQPVPERRIPNRYLGQPSPFTHPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQGQ
SGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVD
EAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAPESYK

--------------------------------------------------------------
>In-frame_ENST00000544094_ENST00000216038_TCGA-69-7761-01A_XPNPEP3_chr22_41282519_+_RTCB_chr22_32784086_length(transcript)=1661nt_BP=1143nt
ACCAGACCATCCTGAATCCTCTGGACTGTTTCCCCTGTATGTTTCCCTGGAAGCTTCAGGCAGTGCCTCATAAGCCAATGGAATCTGTTG
CTAATAGCCACAGCATATCCCTTGCATAATATGACCTCTAGATTACTGCGCCTTAATTGCTTCCCAGCTCTTCTATGCTTTGGTTTAGAA
AAATGAAGTACTGACTTACGGGTGAAGAAAGTATTCAAACAGTTGACATATTTATTTCAGTCAAGAAACAGTTCAGAGGGAGATACAAAC
AAGTAACTTAGTTACAATATAATAGTTATGATGAGAGGAAGTACTGGATGCTAAACAATTATATGAGAGACAGCTCAGGCTGGGGGTGTC
AATGAAAGCCTCTTGGAGGAAGTAGCCTGATATGTTAACTTTCTGCATGCCAGTGGATGTATGTTGTGTTCACAGCGAAGGTACTCCCTT
CAGCCTGTCCCAGAAAGGAGGATTCCAAACCGATACTTAGGCCAGCCCAGCCCCTTTACACACCCACACCTCCTCAGACCAGGGGAGGTA
ACTCCAGGACTATCTCAGGTGGAATATGCACTTCGCAGACACAAACTAATGTCTCTGATCCAGAAGGAAGCTCAAGGGCAGAGTGGGACA
GACCAGACAGTGGTTGTGCTCTCCAACCCTACATACTACATGAGCAACGATATTCCCTATACTTTCCACCAAGACAACAATTTCCTGTAC
CTATGTGGATTCCAAGAGCCTGATAGCATTCTTGTCCTTCAGAGCCTCCCTGGCAAACAATTACCATCACACAAAGCCATACTTTTTGTG
CCTCGGCGAGATCCCAGTCGAGAACTTTGGGATGGTCCGCGATCTGGCACTGATGGAGCAATAGCTCTAACTGGAGTAGACGAAGCCTAT
ACGCTAGAAGAATTTCAACATCTTCTACCAAAAATGAAAGCTGAGACGAACATGGTTTGGTATGACTGGATGAGGCCCTCACATGCACAG
CTTCACTCTGACTATATGCAGCCCCTGACTGAGGCCAAAGCCAAGAGCAAGAACAAGGTTCGGGGTGTTCAGCAGCTGATACAGCGCCTC
CGGCTGATCAAGTCTCCTGCAGAAATTGAACGAATGCAGATTGCTGGGAAGCTGACATCACAGGCTCCTGAGTCCTATAAGAATGTGACA
GATGTGGTAAATACCTGCCATGATGCTGGAATCAGCAAGAAAGCCATTAAACTGAGACCAATTGCTGTGATCAAAGGATAGAACCTTGGA
CAGCAGGGCTGCCTGACACCACCAACCCTCTCTGAAGTGGAAGTGGACTGACATGCTCTTCTGACATCAGACTCAAGGCGGGACAAGTTG
CAAAGTGTGCAGCTGTAACTGCTCACGCCAAAATGGCTGATGGGGAGGCTGCTGCTTTCAGGGGCCCGTGCTTGTAAAATAACCTTCCAG
GAAGAGGCACATTGCCCACCTTTGGAAAGGGAGGAATATGCCTTCTCCTTGGTTGTTCCACAGAGTTTTAGGAAAATCTGTTAGGGATGG
GTAGATGTCAAACTGCCTTACGCAGTCATACTGATCTTTAGCCATCAGATTGATCTTCTTCACACCAAGCTCTGTTTACATTCCGAGAGG

>In-frame_ENST00000544094_ENST00000216038_TCGA-69-7761-01A_XPNPEP3_chr22_41282519_+_RTCB_chr22_32784086_length(amino acids)=282AA_start in transcript=402_stop in transcript=1250
MHASGCMLCSQRRYSLQPVPERRIPNRYLGQPSPFTHPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYM
SNDIPYTFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKMKA
ETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAPESYKNVTDVVNTCHDAGISKK

--------------------------------------------------------------
>In-frame_ENST00000414396_ENST00000216038_TCGA-69-7761-01A_XPNPEP3_chr22_41282519_+_RTCB_chr22_32784086_length(transcript)=1402nt_BP=884nt
GCTGGCCCGGTTTCCTGGCGACGCGGCCCTGCAGGCGGTTGCGTTCCCCGTCGTTACCCTCTTTCTCTTCCCGACGCGTGAGTTAGGCCG
TAATGCCTTGGCTGCTCTCAGCCCCCAAGCTGGTTCCCGCTGTAGCAAACGTCCGCGGCCTCTCAGGATGTATGTTGTGTTCACAGCGAA
GGTACTCCCTTCAGCCTGTCCCAGAAAGGAGGATTCCAAACCGATACTTAGGCCAGCCCAGCCCCTTTACACACCCACACCTCCTCAGAC
CAGGGGAGGTAACTCCAGGACTATCTCAGGTGGAATATGCACTTCGCAGACACAAACTAATGTCTCTGATCCAGAAGGAAGCTCAAGGGC
AGAGTGGGACAGACCAGACAGTGGTTGTGCTCTCCAACCCTACATACTACATGAGCAACGATATTCCCTATACTTTCCACCAAGACAACA
ATTTCCTGTACCTATGTGGATTCCAAGAGCCTGATAGCATTCTTGTCCTTCAGAGCCTCCCTGGCAAACAATTACCATCACACAAAGCCA
TACTTTTTGTGCCTCGGCGAGATCCCAGTCGAGAACTTTGGGATGGTCCGCGATCTGGCACTGATGGAGCAATAGCTCTAACTGGAGTAG
ACGAAGCCTATACGCTAGAAGAATTTCAACATCTTCTACCAAAAATGAAAGCTGAGACGAACATGGTTTGGTATGACTGGATGAGGCCCT
CACATGCACAGCTTCACTCTGACTATATGCAGCCCCTGACTGAGGCCAAAGCCAAGAGCAAGAACAAGGTTCGGGGTGTTCAGCAGCTGA
TACAGCGCCTCCGGCTGATCAAGTCTCCTGCAGAAATTGAACGAATGCAGATTGCTGGGAAGCTGACATCACAGGCTCCTGAGTCCTATA
AGAATGTGACAGATGTGGTAAATACCTGCCATGATGCTGGAATCAGCAAGAAAGCCATTAAACTGAGACCAATTGCTGTGATCAAAGGAT
AGAACCTTGGACAGCAGGGCTGCCTGACACCACCAACCCTCTCTGAAGTGGAAGTGGACTGACATGCTCTTCTGACATCAGACTCAAGGC
GGGACAAGTTGCAAAGTGTGCAGCTGTAACTGCTCACGCCAAAATGGCTGATGGGGAGGCTGCTGCTTTCAGGGGCCCGTGCTTGTAAAA
TAACCTTCCAGGAAGAGGCACATTGCCCACCTTTGGAAAGGGAGGAATATGCCTTCTCCTTGGTTGTTCCACAGAGTTTTAGGAAAATCT
GTTAGGGATGGGTAGATGTCAAACTGCCTTACGCAGTCATACTGATCTTTAGCCATCAGATTGATCTTCTTCACACCAAGCTCTGTTTAC

>In-frame_ENST00000414396_ENST00000216038_TCGA-69-7761-01A_XPNPEP3_chr22_41282519_+_RTCB_chr22_32784086_length(amino acids)=299AA_start in transcript=92_stop in transcript=991
MPWLLSAPKLVPAVANVRGLSGCMLCSQRRYSLQPVPERRIPNRYLGQPSPFTHPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQGQ
SGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVD
EAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAPESYK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for XPNPEP3-RTCB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneXPNPEP3chr22:41282519chr22:32784086ENST00000357137+41054_79264.0508.0TNFRSF1B
HgeneXPNPEP3chr22:41282519chr22:32784086ENST00000414396+4554_79264.0279.0TNFRSF1B
HgeneXPNPEP3chr22:41282519chr22:32784086ENST00000541156+4754_79264.0243.0TNFRSF1B
HgeneXPNPEP3chr22:41282519chr22:32784086ENST00000544094+41454_79241.0219.33333333333334TNFRSF1B


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for XPNPEP3-RTCB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneRTCBQ9Y3I0DB02772SucroseSmall moleculeApproved|Experimental|Investigational
TgeneRTCBQ9Y3I0DB02772SucroseSmall moleculeApproved|Experimental|Investigational
TgeneRTCBQ9Y3I0DB02772SucroseSmall moleculeApproved|Experimental|Investigational

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Related Diseases for XPNPEP3-RTCB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneXPNPEP3C0687120Nephronophthisis1GENOMICS_ENGLAND
HgeneXPNPEP3C3150419NEPHRONOPHTHISIS-LIKE NEPHROPATHY 11CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneXPNPEP3C3280617Nephronophthisis-like nephropathy1GENOMICS_ENGLAND
HgeneXPNPEP3C4277690Ciliopathies1GENOMICS_ENGLAND