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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:XPR1-KHDRBS1 (FusionGDB2 ID:99056)

Fusion Gene Summary for XPR1-KHDRBS1

check button Fusion gene summary
Fusion gene informationFusion gene name: XPR1-KHDRBS1
Fusion gene ID: 99056
HgeneTgene
Gene symbol

XPR1

KHDRBS1

Gene ID

9213

10657

Gene namexenotropic and polytropic retrovirus receptor 1KH RNA binding domain containing, signal transduction associated 1
SynonymsIBGC6|SLC53A1|SYG1|X3Sam68|p62|p68
Cytomap

1q25.3

1p35.2

Type of geneprotein-codingprotein-coding
Descriptionxenotropic and polytropic retrovirus receptor 1X-receptorprotein SYG1 homologsolute carrier family 53 (phosphate exporter), member 1xenotropic and polytropic murine leukemia virus receptor X3KH domain-containing, RNA-binding, signal transduction-associated protein 1GAP-associated tyrosine phosphoprotein p62 (Sam68)KH domain containing, RNA binding, signal transduction associated 1p21 Ras GTPase-activating protein-associated p62src-associa
Modification date2020031320200327
UniProtAcc.

Q07666

Ensembl transtripts involved in fusion geneENST00000367590, ENST00000367589, 
ENST00000467345, 		ENST00000327300, 
ENST00000307714, ENST00000492989, 
Fusion gene scores* DoF score24 X 7 X 12=201611 X 8 X 6=528
# samples 2712
** MAII scorelog2(27/2016*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/528*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: XPR1 [Title/Abstract] AND KHDRBS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointXPR1(180651547)-KHDRBS1(32495899), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKHDRBS1

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

24514149

TgeneKHDRBS1

GO:0007166

cell surface receptor signaling pathway

9045636

TgeneKHDRBS1

GO:0031647

regulation of protein stability

21613532

TgeneKHDRBS1

GO:0045948

positive regulation of translational initiation

21613532

TgeneKHDRBS1

GO:0046833

positive regulation of RNA export from nucleus

21613532


check buttonFusion gene breakpoints across XPR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KHDRBS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8060-01AXPR1chr1

180651547

+KHDRBS1chr1

32495899

+


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Fusion Gene ORF analysis for XPR1-KHDRBS1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000367590ENST00000327300XPR1chr1

180651547

+KHDRBS1chr1

32495899

+
5CDS-3UTRENST00000367590ENST00000307714XPR1chr1

180651547

+KHDRBS1chr1

32495899

+
5CDS-3UTRENST00000367590ENST00000492989XPR1chr1

180651547

+KHDRBS1chr1

32495899

+
In-frameENST00000367589ENST00000327300XPR1chr1

180651547

+KHDRBS1chr1

32495899

+
5CDS-3UTRENST00000367589ENST00000307714XPR1chr1

180651547

+KHDRBS1chr1

32495899

+
5CDS-3UTRENST00000367589ENST00000492989XPR1chr1

180651547

+KHDRBS1chr1

32495899

+
intron-3CDSENST00000467345ENST00000327300XPR1chr1

180651547

+KHDRBS1chr1

32495899

+
intron-3UTRENST00000467345ENST00000307714XPR1chr1

180651547

+KHDRBS1chr1

32495899

+
intron-3UTRENST00000467345ENST00000492989XPR1chr1

180651547

+KHDRBS1chr1

32495899

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367590XPR1chr1180651547+ENST00000327300KHDRBS1chr132495899+25273191981268356
ENST00000367589XPR1chr1180651547+ENST00000327300KHDRBS1chr132495899+24992911701240356

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367590ENST00000327300XPR1chr1180651547+KHDRBS1chr132495899+0.0002500270.99974996
ENST00000367589ENST00000327300XPR1chr1180651547+KHDRBS1chr132495899+0.0002353860.9997646

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Fusion Genomic Features for XPR1-KHDRBS1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
XPR1chr1180651547+KHDRBS1chr132495898+3.17E-121
XPR1chr1180651547+KHDRBS1chr132495898+3.17E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for XPR1-KHDRBS1


check button Go to

FGviewer for the breakpoints of chr1:180651547-chr1:32495899

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KHDRBS1

Q07666

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (By similarity). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKHDRBS1chr1:180651547chr1:32495899ENST0000032730009282_292127.33333333333333444.0Compositional biasDMA/Gly-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST0000032730009295_301127.33333333333333444.0Compositional biasPro-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST0000032730009302_332127.33333333333333444.0Compositional biasArg/Gly-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST0000032730009334_363127.33333333333333444.0Compositional biasPro-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST0000049298908282_292127.33333333333333405.0Compositional biasDMA/Gly-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST0000049298908295_301127.33333333333333405.0Compositional biasPro-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST0000049298908302_332127.33333333333333405.0Compositional biasArg/Gly-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST0000049298908334_363127.33333333333333405.0Compositional biasPro-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST0000032730009171_197127.33333333333333444.0DomainKH
TgeneKHDRBS1chr1:180651547chr1:32495899ENST0000049298908171_197127.33333333333333405.0DomainKH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+2141_17740.333333333333336632.0DomainSPX
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214439_64340.333333333333336632.0DomainEXS
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+2151_17740.333333333333336697.0DomainSPX
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215439_64340.333333333333336697.0DomainEXS
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214158_16540.333333333333336632.0RegionImportant for inositol polyphosphate binding
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215158_16540.333333333333336697.0RegionImportant for inositol polyphosphate binding
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+2141_23640.333333333333336632.0Topological domainCytoplasmic
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214258_26440.333333333333336632.0Topological domainExtracellular
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214286_31840.333333333333336632.0Topological domainCytoplasmic
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214340_34540.333333333333336632.0Topological domainExtracellular
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214369_37640.333333333333336632.0Topological domainCytoplasmic
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214398_40240.333333333333336632.0Topological domainExtracellular
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214424_47340.333333333333336632.0Topological domainCytoplasmic
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214497_50740.333333333333336632.0Topological domainExtracellular
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214529_69640.333333333333336632.0Topological domainCytoplasmic
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+2151_23640.333333333333336697.0Topological domainCytoplasmic
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215258_26440.333333333333336697.0Topological domainExtracellular
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215286_31840.333333333333336697.0Topological domainCytoplasmic
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215340_34540.333333333333336697.0Topological domainExtracellular
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215369_37640.333333333333336697.0Topological domainCytoplasmic
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215398_40240.333333333333336697.0Topological domainExtracellular
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215424_47340.333333333333336697.0Topological domainCytoplasmic
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215497_50740.333333333333336697.0Topological domainExtracellular
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215529_69640.333333333333336697.0Topological domainCytoplasmic
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214237_25740.333333333333336632.0TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214265_28540.333333333333336632.0TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214319_33940.333333333333336632.0TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214346_36840.333333333333336632.0TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214377_39740.333333333333336632.0TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214403_42340.333333333333336632.0TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214474_49640.333333333333336632.0TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214508_52840.333333333333336632.0TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215237_25740.333333333333336697.0TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215265_28540.333333333333336697.0TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215319_33940.333333333333336697.0TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215346_36840.333333333333336697.0TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215377_39740.333333333333336697.0TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215403_42340.333333333333336697.0TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215474_49640.333333333333336697.0TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215508_52840.333333333333336697.0TransmembraneHelical
TgeneKHDRBS1chr1:180651547chr1:32495899ENST000003273000934_41127.33333333333333444.0Compositional biasPro-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST000003273000944_55127.33333333333333444.0Compositional biasDMA/Gly-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST000003273000959_89127.33333333333333444.0Compositional biasPro-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST000004929890834_41127.33333333333333405.0Compositional biasPro-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST000004929890844_55127.33333333333333405.0Compositional biasDMA/Gly-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST000004929890859_89127.33333333333333405.0Compositional biasPro-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST0000032730009100_260127.33333333333333444.0RegionInvolved in homodimerization
TgeneKHDRBS1chr1:180651547chr1:32495899ENST0000049298908100_260127.33333333333333405.0RegionInvolved in homodimerization


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Fusion Gene Sequence for XPR1-KHDRBS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000367590_ENST00000327300_TCGA-BR-8060-01A_XPR1_chr1_180651547_+_KHDRBS1_chr1_32495899_length(transcript)=2527nt_BP=319nt
GCGGGGAGGGGCGGGGCTATGGAGAGGAGGAGGAAGATGGCGGGCGGGCTGCTCTGAAGAGACCTCGGCGGCGGCGGAGGAGGAGAGAAG
CGCAGCGCCGCGCCGCGCCGGGGCCCATGTGGGGAGGAGTCGGAGTCGCTGTTGCCGCCGCCGCCTGTAGCTGCTGGACCCGAGTGGGAG
TGAGGGGGAAACGGCAGGATGAAGTTCGCCGAGCACCTCTCCGCGCACATCACTCCCGAGTGGAGGAAGCAATACATCCAGTATGAGGCT
TTCAAGGATATGCTGTATTCAGCTCAGGACCAGGCACCTTCTGTGGAAGAAATTGAGAAGATTCAGAAAGGAGACTCAAAAAAGGATGAT
GAGGAGAATTACTTGGATTTATTTTCTCATAAGAACATGAAACTGAAAGAGCGAGTGCTGATACCTGTCAAGCAGTATCCCAAGTTCAAT
TTTGTGGGGAAGATTCTTGGACCACAAGGGAATACAATCAAAAGACTGCAGGAAGAGACTGGTGCAAAGATCTCTGTATTGGGAAAGGGC
TCAATGAGAGACAAAGCCAAGGAGGAAGAGCTGCGCAAAGGTGGAGACCCCAAATATGCCCACTTGAATATGGATCTGCATGTCTTCATT
GAAGTCTTTGGACCCCCATGTGAGGCTTATGCTCTTATGGCCCATGCCATGGAGGAAGTCAAGAAATTTCTAGTACCGGATATGATGGAT
GATATCTGTCAGGAGCAATTTCTAGAGCTGTCCTACTTGAATGGAGTACCTGAACCCTCTCGTGGACGTGGGGTGCCAGTGAGAGGCCGG
GGAGCTGCACCTCCTCCACCACCTGTTCCCAGGGGCCGTGGTGTTGGACCACCTCGGGGGGCTTTGGTACGTGGTACACCAGTAAGGGGA
GCCATCACCAGAGGTGCCACTGTGACTCGAGGCGTGCCACCCCCACCTACTGTGAGGGGTGCTCCAGCACCAAGAGCACGGACAGCGGGC
ATCCAGAGGATACCTTTGCCTCCACCTCCTGCACCAGAAACATATGAAGAATATGGATATGATGATACATACGCAGAACAAAGTTACGAA
GGCTACGAAGGCTATTACAGCCAGAGTCAAGGGGACTCAGAATATTATGACTATGGACATGGGGAGGTTCAAGATTCTTATGAAGCTTAT
GGCCAGGACGACTGGAATGGGACCAGGCCGTCGCTGAAGGCCCCTCCTGCTAGGCCAGTGAAGGGAGCATACAGAGAGCACCCATATGGA
CGTTATTAAAAACAAACATGAGGGGAAAATATCAGTTATGAGCAAAGTTGTTACTGATTTCTTGTATCTCCCAGGATTCCTGTTGCTTTA
CCCACAACAGACAAGTAATTGTCTAAGTGTTTTTCTTCGTGGTCCCCTTCTTCTCCCCACCTTATTCCATTCTTAACTCTGCATTCTGGC
TTCTGTATGTAGTATTTTAAAATGAGTTAAAATAGATTTAGGAATATTGAATTAATTTTTTAAGTGTGTAGATGCTTTTTTCTTTGTTGT
TTAAATATAAACAGAAGTGTACCTTTTATAATAAAAAAAAGAAGTTGAGTAAAAAAAAAAAACACACAAACCTGTTAGTTTCAAAAATGA
CATTGCTTGCTTAAAGGTTCTGAAGTAAAGGCTTGTTAAGTTTCTCTTAGTTTTGATTTGAGGCATCCCGTAAAGTTGTAGTTGCAGAAT
CCCAAACTAGGCTACATTTCAAAATTCAGGGCTGTTTAAGATTTAAAATCACAAACATTAACGGCAGTAGGCACCACCATGTAAAAGTGA
GCTCAGACGTCTCTAAAAAATGTTTCCTTTATAAAAGCACATGGCGGTTGAATCTTAAGGTTAAATTTTAATATGAAAGATCCTCATGAA
TTAAATAGTTGATGCAATTTTTAACGTTAATTGATATAAAAAAAAAAACAACAAAATTAGGCTTGTAAAACTGACTTTTTCATTACGTGG
GTTTTGAAATCTAGCCCCAGACATACTGTGTTGAGAGATACTTAGAGGGAGGGAGTAGGTTTTGAAGAGGTTGATGGTGGTGGGGAGGGA
AGGCCTCCTGAATTGAGTTTGATGCAGAGCTTTTTAGCCATGAAGAATCTTTCAGTCATAGTACTAATAATTAAATTTTCAGTATTTAAA
AAGACAAAGTATTTTGTCCATTTGAGATTCTGCACTCCATGAAAAGTTCACTTGGACGCTGGGGCCAAAAGCTGTTGATTTTCTTAAGTT
GACGGTTGTCAATATATCGAACTGTTCCCAAGTTAGTCAAGTATGTCTCAACACTAGCATGATATAAAAAGGGACACTGCAGCTGAATGA
AAAAGGAATCAAAATCCACTTTGTACATAAGTTAAAGTCCTAATTGGATTTGTACCGTCCTCCCATTTTGTTCTCGGAAGATTAAATGCT
ACATGTGTAAGTCTGCCTAAATAGGTAGCTTAAACTTATGTCAAAATGTCTGCAGCAGTTTGTCAATAAAGTTTAGTCCTTTTTTAATCA

>In-frame_ENST00000367590_ENST00000327300_TCGA-BR-8060-01A_XPR1_chr1_180651547_+_KHDRBS1_chr1_32495899_length(amino acids)=356AA_start in transcript=198_stop in transcript=1268
MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEEIEKIQKGDSKKDDEENYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKIL
GPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEELRKGGDPKYAHLNMDLHVFIEVFGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQ
FLELSYLNGVPEPSRGRGVPVRGRGAAPPPPPVPRGRGVGPPRGALVRGTPVRGAITRGATVTRGVPPPPTVRGAPAPRARTAGIQRIPL

--------------------------------------------------------------
>In-frame_ENST00000367589_ENST00000327300_TCGA-BR-8060-01A_XPR1_chr1_180651547_+_KHDRBS1_chr1_32495899_length(transcript)=2499nt_BP=291nt
GGAGGAAGATGGCGGGCGGGCTGCTCTGAAGAGACCTCGGCGGCGGCGGAGGAGGAGAGAAGCGCAGCGCCGCGCCGCGCCGGGGCCCAT
GTGGGGAGGAGTCGGAGTCGCTGTTGCCGCCGCCGCCTGTAGCTGCTGGACCCGAGTGGGAGTGAGGGGGAAACGGCAGGATGAAGTTCG
CCGAGCACCTCTCCGCGCACATCACTCCCGAGTGGAGGAAGCAATACATCCAGTATGAGGCTTTCAAGGATATGCTGTATTCAGCTCAGG
ACCAGGCACCTTCTGTGGAAGAAATTGAGAAGATTCAGAAAGGAGACTCAAAAAAGGATGATGAGGAGAATTACTTGGATTTATTTTCTC
ATAAGAACATGAAACTGAAAGAGCGAGTGCTGATACCTGTCAAGCAGTATCCCAAGTTCAATTTTGTGGGGAAGATTCTTGGACCACAAG
GGAATACAATCAAAAGACTGCAGGAAGAGACTGGTGCAAAGATCTCTGTATTGGGAAAGGGCTCAATGAGAGACAAAGCCAAGGAGGAAG
AGCTGCGCAAAGGTGGAGACCCCAAATATGCCCACTTGAATATGGATCTGCATGTCTTCATTGAAGTCTTTGGACCCCCATGTGAGGCTT
ATGCTCTTATGGCCCATGCCATGGAGGAAGTCAAGAAATTTCTAGTACCGGATATGATGGATGATATCTGTCAGGAGCAATTTCTAGAGC
TGTCCTACTTGAATGGAGTACCTGAACCCTCTCGTGGACGTGGGGTGCCAGTGAGAGGCCGGGGAGCTGCACCTCCTCCACCACCTGTTC
CCAGGGGCCGTGGTGTTGGACCACCTCGGGGGGCTTTGGTACGTGGTACACCAGTAAGGGGAGCCATCACCAGAGGTGCCACTGTGACTC
GAGGCGTGCCACCCCCACCTACTGTGAGGGGTGCTCCAGCACCAAGAGCACGGACAGCGGGCATCCAGAGGATACCTTTGCCTCCACCTC
CTGCACCAGAAACATATGAAGAATATGGATATGATGATACATACGCAGAACAAAGTTACGAAGGCTACGAAGGCTATTACAGCCAGAGTC
AAGGGGACTCAGAATATTATGACTATGGACATGGGGAGGTTCAAGATTCTTATGAAGCTTATGGCCAGGACGACTGGAATGGGACCAGGC
CGTCGCTGAAGGCCCCTCCTGCTAGGCCAGTGAAGGGAGCATACAGAGAGCACCCATATGGACGTTATTAAAAACAAACATGAGGGGAAA
ATATCAGTTATGAGCAAAGTTGTTACTGATTTCTTGTATCTCCCAGGATTCCTGTTGCTTTACCCACAACAGACAAGTAATTGTCTAAGT
GTTTTTCTTCGTGGTCCCCTTCTTCTCCCCACCTTATTCCATTCTTAACTCTGCATTCTGGCTTCTGTATGTAGTATTTTAAAATGAGTT
AAAATAGATTTAGGAATATTGAATTAATTTTTTAAGTGTGTAGATGCTTTTTTCTTTGTTGTTTAAATATAAACAGAAGTGTACCTTTTA
TAATAAAAAAAAGAAGTTGAGTAAAAAAAAAAAACACACAAACCTGTTAGTTTCAAAAATGACATTGCTTGCTTAAAGGTTCTGAAGTAA
AGGCTTGTTAAGTTTCTCTTAGTTTTGATTTGAGGCATCCCGTAAAGTTGTAGTTGCAGAATCCCAAACTAGGCTACATTTCAAAATTCA
GGGCTGTTTAAGATTTAAAATCACAAACATTAACGGCAGTAGGCACCACCATGTAAAAGTGAGCTCAGACGTCTCTAAAAAATGTTTCCT
TTATAAAAGCACATGGCGGTTGAATCTTAAGGTTAAATTTTAATATGAAAGATCCTCATGAATTAAATAGTTGATGCAATTTTTAACGTT
AATTGATATAAAAAAAAAAACAACAAAATTAGGCTTGTAAAACTGACTTTTTCATTACGTGGGTTTTGAAATCTAGCCCCAGACATACTG
TGTTGAGAGATACTTAGAGGGAGGGAGTAGGTTTTGAAGAGGTTGATGGTGGTGGGGAGGGAAGGCCTCCTGAATTGAGTTTGATGCAGA
GCTTTTTAGCCATGAAGAATCTTTCAGTCATAGTACTAATAATTAAATTTTCAGTATTTAAAAAGACAAAGTATTTTGTCCATTTGAGAT
TCTGCACTCCATGAAAAGTTCACTTGGACGCTGGGGCCAAAAGCTGTTGATTTTCTTAAGTTGACGGTTGTCAATATATCGAACTGTTCC
CAAGTTAGTCAAGTATGTCTCAACACTAGCATGATATAAAAAGGGACACTGCAGCTGAATGAAAAAGGAATCAAAATCCACTTTGTACAT
AAGTTAAAGTCCTAATTGGATTTGTACCGTCCTCCCATTTTGTTCTCGGAAGATTAAATGCTACATGTGTAAGTCTGCCTAAATAGGTAG

>In-frame_ENST00000367589_ENST00000327300_TCGA-BR-8060-01A_XPR1_chr1_180651547_+_KHDRBS1_chr1_32495899_length(amino acids)=356AA_start in transcript=170_stop in transcript=1240
MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEEIEKIQKGDSKKDDEENYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKIL
GPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEELRKGGDPKYAHLNMDLHVFIEVFGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQ
FLELSYLNGVPEPSRGRGVPVRGRGAAPPPPPVPRGRGVGPPRGALVRGTPVRGAITRGATVTRGVPPPPTVRGAPAPRARTAGIQRIPL

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Fusion Gene PPI Analysis for XPR1-KHDRBS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneKHDRBS1chr1:180651547chr1:32495899ENST0000032730009351_443127.33333333333333444.0HNRNPA1
TgeneKHDRBS1chr1:180651547chr1:32495899ENST0000049298908351_443127.33333333333333405.0HNRNPA1
TgeneKHDRBS1chr1:180651547chr1:32495899ENST0000032730009400_420127.33333333333333444.0ZBTB7A
TgeneKHDRBS1chr1:180651547chr1:32495899ENST0000049298908400_420127.33333333333333405.0ZBTB7A


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for XPR1-KHDRBS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for XPR1-KHDRBS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneXPR1C4225335BASAL GANGLIA CALCIFICATION, IDIOPATHIC, 62CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneXPR1C0004782Basal Ganglia Diseases1CTD_human
HgeneXPR1C0006663Calcinosis1CTD_human
HgeneXPR1C0015371Extrapyramidal Disorders1CTD_human
HgeneXPR1C0015624Fanconi Syndrome1GENOMICS_ENGLAND
HgeneXPR1C0263628Tumoral calcinosis1CTD_human
HgeneXPR1C0393590Fahr's syndrome (disorder)1ORPHANET
HgeneXPR1C0521174Microcalcification1CTD_human
HgeneXPR1C0750951Lenticulostriate Disorders1CTD_human