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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:XRCC5-VWA3B (FusionGDB2 ID:99096)

Fusion Gene Summary for XRCC5-VWA3B

check button Fusion gene summary
Fusion gene informationFusion gene name: XRCC5-VWA3B
Fusion gene ID: 99096
HgeneTgene
Gene symbol

XRCC5

VWA3B

Gene ID

7520

200403

Gene nameX-ray repair cross complementing 5von Willebrand factor A domain containing 3B
SynonymsKARP-1|KARP1|KU80|KUB2|Ku86|NFIVSCAR22
Cytomap

2q35

2q11.2

Type of geneprotein-codingprotein-coding
DescriptionX-ray repair cross-complementing protein 586 kDa subunit of Ku antigenATP-dependent DNA helicase 2 subunit 2ATP-dependent DNA helicase II 80 kDa subunitCTC box-binding factor 85 kDa subunitCTC85CTCBFDNA repair protein XRCC5Ku autoantigen, 80kDaKuvon Willebrand factor A domain-containing protein 3BVWA domain-containing protein 3B
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000392133, ENST00000392132, 
ENST00000471649, 		ENST00000435344, 
ENST00000477737, ENST00000451075, 
ENST00000490947, 
Fusion gene scores* DoF score13 X 10 X 7=9106 X 9 X 6=324
# samples 1210
** MAII scorelog2(12/910*10)=-2.92283213947754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: XRCC5 [Title/Abstract] AND VWA3B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointXRCC5(217026771)-VWA3B(98732114), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneXRCC5

GO:0002218

activation of innate immune response

28712728

HgeneXRCC5

GO:0006303

double-strand break repair via nonhomologous end joining

26359349

HgeneXRCC5

GO:0045860

positive regulation of protein kinase activity

22504299

HgeneXRCC5

GO:0071480

cellular response to gamma radiation

26359349


check buttonFusion gene breakpoints across XRCC5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across VWA3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-2392XRCC5chr2

217026771

+VWA3Bchr2

98732114

+


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Fusion Gene ORF analysis for XRCC5-VWA3B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000392133ENST00000435344XRCC5chr2

217026771

+VWA3Bchr2

98732114

+
In-frameENST00000392133ENST00000477737XRCC5chr2

217026771

+VWA3Bchr2

98732114

+
5CDS-5UTRENST00000392133ENST00000451075XRCC5chr2

217026771

+VWA3Bchr2

98732114

+
5CDS-intronENST00000392133ENST00000490947XRCC5chr2

217026771

+VWA3Bchr2

98732114

+
In-frameENST00000392132ENST00000435344XRCC5chr2

217026771

+VWA3Bchr2

98732114

+
In-frameENST00000392132ENST00000477737XRCC5chr2

217026771

+VWA3Bchr2

98732114

+
5CDS-5UTRENST00000392132ENST00000451075XRCC5chr2

217026771

+VWA3Bchr2

98732114

+
5CDS-intronENST00000392132ENST00000490947XRCC5chr2

217026771

+VWA3Bchr2

98732114

+
intron-3CDSENST00000471649ENST00000435344XRCC5chr2

217026771

+VWA3Bchr2

98732114

+
intron-3CDSENST00000471649ENST00000477737XRCC5chr2

217026771

+VWA3Bchr2

98732114

+
intron-5UTRENST00000471649ENST00000451075XRCC5chr2

217026771

+VWA3Bchr2

98732114

+
intron-intronENST00000471649ENST00000490947XRCC5chr2

217026771

+VWA3Bchr2

98732114

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392133XRCC5chr2217026771+ENST00000435344VWA3Bchr298732114+397422957139731301
ENST00000392133XRCC5chr2217026771+ENST00000477737VWA3Bchr298732114+634922957159831970
ENST00000392132XRCC5chr2217026771+ENST00000435344VWA3Bchr298732114+365319745636521199
ENST00000392132XRCC5chr2217026771+ENST00000477737VWA3Bchr298732114+602819745656621868

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392133ENST00000435344XRCC5chr2217026771+VWA3Bchr298732114+0.0019245040.9980755
ENST00000392133ENST00000477737XRCC5chr2217026771+VWA3Bchr298732114+0.0015190350.998481
ENST00000392132ENST00000435344XRCC5chr2217026771+VWA3Bchr298732114+0.0016534420.99834657
ENST00000392132ENST00000477737XRCC5chr2217026771+VWA3Bchr298732114+0.0013548050.99864525

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Fusion Genomic Features for XRCC5-VWA3B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
XRCC5chr2217026771+VWA3Bchr298732114+0.0004831070.99951684
XRCC5chr2217026771+VWA3Bchr298732114+0.0004831070.99951684

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for XRCC5-VWA3B


check button Go to

FGviewer for the breakpoints of chr2:217026771-chr2:98732114

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXRCC5chr2:217026771chr2:98732114ENST00000392132+1621478_519611.3333333333334733.0Compositional biasNote=Pro-rich
HgeneXRCC5chr2:217026771chr2:98732114ENST00000392133+1823478_519611.3333333333334733.0Compositional biasNote=Pro-rich
HgeneXRCC5chr2:217026771chr2:98732114ENST00000392132+1621251_460611.3333333333334733.0DomainNote=Ku
HgeneXRCC5chr2:217026771chr2:98732114ENST00000392133+1823251_460611.3333333333334733.0DomainNote=Ku
HgeneXRCC5chr2:217026771chr2:98732114ENST00000392132+1621138_165611.3333333333334733.0RegionNote=Leucine-zipper
HgeneXRCC5chr2:217026771chr2:98732114ENST00000392133+1823138_165611.3333333333334733.0RegionNote=Leucine-zipper
TgeneVWA3Bchr2:217026771chr2:98732114ENST00000435344114508_68465.33333333333333625.0DomainVWFA
TgeneVWA3Bchr2:217026771chr2:98732114ENST00000477737128508_68465.333333333333331295.0DomainVWFA

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXRCC5chr2:217026771chr2:98732114ENST00000392132+1621720_728611.3333333333334733.0MotifNote=EEXXXDL motif
HgeneXRCC5chr2:217026771chr2:98732114ENST00000392133+1823720_728611.3333333333334733.0MotifNote=EEXXXDL motif


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Fusion Gene Sequence for XRCC5-VWA3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000392133_ENST00000435344_TCGA-25-2392_XRCC5_chr2_217026771_+_VWA3B_chr2_98732114_length(transcript)=3974nt_BP=2295nt
AGAAACCCCACAAAAATTAGCTGGGCTTGGTGGCACACACCTGTGGTCCCAGCTACCTGGGAGGCTGAGCTCTGGATCGTACAAGAAGGG
AGACAAGGACCACTGACAAGATATGCGTTTCAGGCGGCTCAAACACCACACGCTCCCGACTACGGCGGAATGGAGAGAATGTGCGCATGC
TCGGCGGGAATCTGCGCATGCTCGGCGGGAATCTGCGCATGCTCGGAGAGAATCTGCGCATGCTCGGCCGGAATCTGCGCGAGCTCGGCG
GGAATCTGCGCAAGCTCGGCGGGAATCTGCGCATGCTCAGAGTTCCGGGGCACGGTTTCCCCGCCCCTTTCAGGCCTAGCAGGAAACGAA
GCGGCTCTTTCCGCTATCTGCCGCTTGTCCACCGGAAGCGAGTTGCGACACGGCAGGTTCCCGCCCGGAAGAAGCGACCAAAGCGCCTGA
GGACCGGCAACATGGTGCGGTCGGGGAATAAGGCAGCTGTTGTGCTGTGTATGGACGTGGGCTTTACCATGAGTAACTCCATTCCTGGTA
TAGAATCCCCATTTGAACAAGCAAAGAAGGTGATAACCATGTTTGTACAGCGACAGGTGTTTGCTGAGAACAAGGATGAGATTGCTTTAG
TCCTGTTTGGTACAGATGGCACTGACAATCCCCTTTCTGGTGGGGATCAGTATCAGAACATCACAGTGCACAGACATCTGATGCTACCAG
ATTTTGATTTGCTGGAGGACATTGAAAGCAAAATCCAACCAGGTTCTCAACAGGCTGACTTCCTGGATGCACTAATCGTGAGCATGGATG
TGATTCAACATGAAACAATAGGAAAGAAGTTTGAGAAGAGGCATATTGAAATATTCACTGACCTCAGCAGCCGATTCAGCAAAAGTCAGC
TGGATATTATAATTCATAGCTTGAAGAAATGTGACATCTCCCTGCAATTCTTCTTGCCTTTCTCACTTGGCAAGGAAGATGGAAGTGGGG
ACAGAGGAGATGGCCCCTTTCGCTTAGGTGGCCATGGGCCTTCCTTTCCACTAAAAGGAATTACCGAACAGCAAAAAGAAGGTCTTGAGA
TAGTGAAAATGGTGATGATATCTTTAGAAGGTGAAGATGGGTTGGATGAAATTTATTCATTCAGTGAGAGTCTGAGAAAACTGTGCGTCT
TCAAGAAAATTGAGAGGCATTCCATTCACTGGCCCTGCCGACTGACCATTGGCTCCAATTTGTCTATAAGGATTGCAGCCTATAAATCGA
TTCTACAGGAGAGAGTTAAAAAGACTTGGACAGTTGTGGATGCAAAAACCCTAAAAAAAGAAGATATACAAAAAGAAACAGTTTATTGCT
TAAATGATGATGATGAAACTGAAGTTTTAAAAGAGGATATTATTCAAGGGTTCCGCTATGGAAGTGATATAGTTCCTTTCTCTAAAGTGG
ATGAGGAACAAATGAAATATAAATCGGAGGGGAAGTGCTTCTCTGTTTTGGGATTTTGTAAATCTTCTCAGGTTCAGAGAAGATTCTTCA
TGGGAAATCAAGTTCTAAAGGTCTTTGCAGCAAGAGATGATGAGGCAGCTGCAGTTGCACTTTCCTCCCTGATTCATGCTTTGGATGACT
TAGACATGGTGGCCATAGTTCGATATGCTTATGACAAAAGAGCTAATCCTCAAGTCGGCGTGGCTTTTCCTCATATCAAGCATAACTATG
AGTGTTTAGTGTATGTGCAGCTGCCTTTCATGGAAGACTTGCGGCAATACATGTTTTCATCCTTGAAAAACAGTAAGAAATATGCTCCCA
CCGAGGCACAGTTGAATGCTGTTGATGCTTTGATTGACTCCATGAGCTTGGCAAAGAAAGATGAGAAGACAGACACCCTTGAAGACTTGT
TTCCAACCACCAAAATCCCAAATCCTCGATTTCAGAGATTATTTCAGTGTCTGCTGCACAGAGCTTTACATCCCCGGGAGCCTCTACCCC
CAATTCAGCAGCATATTTGGAATATGCTGAATCCTCCCGCTGAGGTGACAACAAAAAGTCAGATTCCTCTCTCTAAAATAAAGACCCTTT
TTCCTCTGATTGAAGCCAAGAAAAAGGATCAAGTGACTGCTCAGGAAATTTTCCAAGACAACCATGAAGATGGACCTACAGCTAAAAAAT
TAAAGACTGAGCAAGGGGGAGCCCACTTCAGCGTCTCCAGTCTGGCTGAAGGCAGTGTCACCTCTGTTGGAAGTGTGAATCCTGCTGAAA
ACTTCCGTGTTCTAGTGAAACAGAAGAAGGCCAGCTTTGAGGAAGATTATGTGGCGTCTCTGGGGAGACCTGTGGCTTCTCGGTATGCTG
ATGGTCTGTTTCCACAGCTCTACAGAGCAGAAGATGGCAGAGTATACAATCTGACAGCTAAATCAGAACTGATTTATCAGTTTGTGGAAC
ATTTAACACAAGCTGTGGAGAGCTACAAGCAGCGAATGGACTGGCTCACCAGCAAGAGCCGGCAGATTTTTGGTGTCATCTTGGAACAGT
GCGTCACCATAGTGCTGGATTTTGGCGGCATTCTGGAGGGGGAGCTTGATCTGTGCCGAGAGGCTCTAACAATGGTTCTCCAGGAGCAGG
TGGCTCACATAACCGAGTTCAATATCATACGGGTTTCTCAAGAGCCTGTGAAGTGGCAGGAAAATGCTACTCCTGTGACCGAACAGTCCA
TAGCTACTGCCATCAGTTGGGTTGAGAAACTGACGGTTGAGCTGACTGTGAGCGAGGCTGGCCGCCTGGATGCTCTGCTGGAAGCCGGGA
GAGACAAGACTATTGAATCCATTTACTACTTTGTGGTGGGGGATGTTCCTGAAGAATCCAAGGAGCTTCTCCTCCAGAGGGCCTTGGAGA
TCCCGTGTCCAGTCTACACAGTGTCCTTCAACGCCAGAGGAGAAGGCACTATAGCTTTTCTAAAGGATCTGAGTGCCAAGACCCACAGCA
GATTCCACGCATTTGCCGAGAGAACAGAGTGTGTAGAATTTCCTGCATTCTCCACAAAGGATGGTGACAATGTGATGACTTGGAATTCAA
GGAAACTGAAAGGAAAACTCCCTCCAGGAGCTGGAGTCAGAGAGGACGTGTTTCTCGTTTGGCAAGAGATGGAGGAAGCCTGCAGCACGC
TGGCCCAGATCCAGAGGCTGGTGGCCGAGCCTCCCAAGCCCGACGTGGCCACTGTGGACTGCGAGTCAGAAACAACCTCTGTTGAGATTG
CATCGAATCCAGAAGACACCTGGGACTCTAAGACATGGCTGCAGAAATATGGCTTGAAGGCCCAGAAGCTATCCTTGTATGATGTGCTTG
CCGACTGCTCTTTCCGCCACGCTGATGGGGTTGTGGATATAAAAGCCAAACCGGAGAATGAGTCCGTGCAGACCAGTGCGGAGACGAACA
AGAAGACAGTCCATGCAAAATATTGCAGCAGGTTTGTCCATGCTCCCTGGAAGGATGGGAGCTTGGTCCACGTCAACATTACCAAAGAGA
AGTGCAAGTGGTACAGTGAGAGAATCCACACAGCCCTGGCCCGGATCCGAAGGAGGATTAAATGGCTACAGGATGGGAGTCAAAGCCTCT
TTGGAAGATTGCATAATGATTGCATCTACATTCTCATTGACACGTCTCACTCAATGAAGAGCAAACTGGACTTGGTGAAGGACAAGATCA
TTCAGTTCATACAGGAACAGCTGAAATATAAAAGTAAGTTTAACTTTGTGAAGTTTGATGGTCAAGCAGTTGCTTGGCGGGAACAACTTG
CTGAAGTCAATGAAGATAATTTGGAACAGGCTCAGTCCTGGATTAGAGACATAAAGATTGGAAGCTCCACAAACACCCTGAGTGCCCTGA
AAACTGCTTTTGCTGATAAAGAAACACAGGCAATCTACCTTCTGACCGATGGGAGACCTGATCAGGGAACATCATCTCATTTACTCCTCA

>In-frame_ENST00000392133_ENST00000435344_TCGA-25-2392_XRCC5_chr2_217026771_+_VWA3B_chr2_98732114_length(amino acids)=1301AA_start in transcript=71_stop in transcript=3973
MDRTRRETRTTDKICVSGGSNTTRSRLRRNGENVRMLGGNLRMLGGNLRMLGENLRMLGRNLRELGGNLRKLGGNLRMLRVPGHGFPAPF
RPSRKRSGSFRYLPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAEN
KDEIALVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSS
RFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSES
LRKLCVFKKIERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDI
VPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFP
HIKHNYECLVYVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALH
PREPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIKTLFPLIEAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVG
SVNPAENFRVLVKQKKASFEEDYVASLGRPVASRYADGLFPQLYRAEDGRVYNLTAKSELIYQFVEHLTQAVESYKQRMDWLTSKSRQIF
GVILEQCVTIVLDFGGILEGELDLCREALTMVLQEQVAHITEFNIIRVSQEPVKWQENATPVTEQSIATAISWVEKLTVELTVSEAGRLD
ALLEAGRDKTIESIYYFVVGDVPEESKELLLQRALEIPCPVYTVSFNARGEGTIAFLKDLSAKTHSRFHAFAERTECVEFPAFSTKDGDN
VMTWNSRKLKGKLPPGAGVREDVFLVWQEMEEACSTLAQIQRLVAEPPKPDVATVDCESETTSVEIASNPEDTWDSKTWLQKYGLKAQKL
SLYDVLADCSFRHADGVVDIKAKPENESVQTSAETNKKTVHAKYCSRFVHAPWKDGSLVHVNITKEKCKWYSERIHTALARIRRRIKWLQ
DGSQSLFGRLHNDCIYILIDTSHSMKSKLDLVKDKIIQFIQEQLKYKSKFNFVKFDGQAVAWREQLAEVNEDNLEQAQSWIRDIKIGSST

--------------------------------------------------------------
>In-frame_ENST00000392133_ENST00000477737_TCGA-25-2392_XRCC5_chr2_217026771_+_VWA3B_chr2_98732114_length(transcript)=6349nt_BP=2295nt
AGAAACCCCACAAAAATTAGCTGGGCTTGGTGGCACACACCTGTGGTCCCAGCTACCTGGGAGGCTGAGCTCTGGATCGTACAAGAAGGG
AGACAAGGACCACTGACAAGATATGCGTTTCAGGCGGCTCAAACACCACACGCTCCCGACTACGGCGGAATGGAGAGAATGTGCGCATGC
TCGGCGGGAATCTGCGCATGCTCGGCGGGAATCTGCGCATGCTCGGAGAGAATCTGCGCATGCTCGGCCGGAATCTGCGCGAGCTCGGCG
GGAATCTGCGCAAGCTCGGCGGGAATCTGCGCATGCTCAGAGTTCCGGGGCACGGTTTCCCCGCCCCTTTCAGGCCTAGCAGGAAACGAA
GCGGCTCTTTCCGCTATCTGCCGCTTGTCCACCGGAAGCGAGTTGCGACACGGCAGGTTCCCGCCCGGAAGAAGCGACCAAAGCGCCTGA
GGACCGGCAACATGGTGCGGTCGGGGAATAAGGCAGCTGTTGTGCTGTGTATGGACGTGGGCTTTACCATGAGTAACTCCATTCCTGGTA
TAGAATCCCCATTTGAACAAGCAAAGAAGGTGATAACCATGTTTGTACAGCGACAGGTGTTTGCTGAGAACAAGGATGAGATTGCTTTAG
TCCTGTTTGGTACAGATGGCACTGACAATCCCCTTTCTGGTGGGGATCAGTATCAGAACATCACAGTGCACAGACATCTGATGCTACCAG
ATTTTGATTTGCTGGAGGACATTGAAAGCAAAATCCAACCAGGTTCTCAACAGGCTGACTTCCTGGATGCACTAATCGTGAGCATGGATG
TGATTCAACATGAAACAATAGGAAAGAAGTTTGAGAAGAGGCATATTGAAATATTCACTGACCTCAGCAGCCGATTCAGCAAAAGTCAGC
TGGATATTATAATTCATAGCTTGAAGAAATGTGACATCTCCCTGCAATTCTTCTTGCCTTTCTCACTTGGCAAGGAAGATGGAAGTGGGG
ACAGAGGAGATGGCCCCTTTCGCTTAGGTGGCCATGGGCCTTCCTTTCCACTAAAAGGAATTACCGAACAGCAAAAAGAAGGTCTTGAGA
TAGTGAAAATGGTGATGATATCTTTAGAAGGTGAAGATGGGTTGGATGAAATTTATTCATTCAGTGAGAGTCTGAGAAAACTGTGCGTCT
TCAAGAAAATTGAGAGGCATTCCATTCACTGGCCCTGCCGACTGACCATTGGCTCCAATTTGTCTATAAGGATTGCAGCCTATAAATCGA
TTCTACAGGAGAGAGTTAAAAAGACTTGGACAGTTGTGGATGCAAAAACCCTAAAAAAAGAAGATATACAAAAAGAAACAGTTTATTGCT
TAAATGATGATGATGAAACTGAAGTTTTAAAAGAGGATATTATTCAAGGGTTCCGCTATGGAAGTGATATAGTTCCTTTCTCTAAAGTGG
ATGAGGAACAAATGAAATATAAATCGGAGGGGAAGTGCTTCTCTGTTTTGGGATTTTGTAAATCTTCTCAGGTTCAGAGAAGATTCTTCA
TGGGAAATCAAGTTCTAAAGGTCTTTGCAGCAAGAGATGATGAGGCAGCTGCAGTTGCACTTTCCTCCCTGATTCATGCTTTGGATGACT
TAGACATGGTGGCCATAGTTCGATATGCTTATGACAAAAGAGCTAATCCTCAAGTCGGCGTGGCTTTTCCTCATATCAAGCATAACTATG
AGTGTTTAGTGTATGTGCAGCTGCCTTTCATGGAAGACTTGCGGCAATACATGTTTTCATCCTTGAAAAACAGTAAGAAATATGCTCCCA
CCGAGGCACAGTTGAATGCTGTTGATGCTTTGATTGACTCCATGAGCTTGGCAAAGAAAGATGAGAAGACAGACACCCTTGAAGACTTGT
TTCCAACCACCAAAATCCCAAATCCTCGATTTCAGAGATTATTTCAGTGTCTGCTGCACAGAGCTTTACATCCCCGGGAGCCTCTACCCC
CAATTCAGCAGCATATTTGGAATATGCTGAATCCTCCCGCTGAGGTGACAACAAAAAGTCAGATTCCTCTCTCTAAAATAAAGACCCTTT
TTCCTCTGATTGAAGCCAAGAAAAAGGATCAAGTGACTGCTCAGGAAATTTTCCAAGACAACCATGAAGATGGACCTACAGCTAAAAAAT
TAAAGACTGAGCAAGGGGGAGCCCACTTCAGCGTCTCCAGTCTGGCTGAAGGCAGTGTCACCTCTGTTGGAAGTGTGAATCCTGCTGAAA
ACTTCCGTGTTCTAGTGAAACAGAAGAAGGCCAGCTTTGAGGAAGATTATGTGGCGTCTCTGGGGAGACCTGTGGCTTCTCGGTATGCTG
ATGGTCTGTTTCCACAGCTCTACAGAGCAGAAGATGGCAGAGTATACAATCTGACAGCTAAATCAGAACTGATTTATCAGTTTGTGGAAC
ATTTAACACAAGCTGTGGAGAGCTACAAGCAGCGAATGGACTGGCTCACCAGCAAGAGCCGGCAGATTTTTGGTGTCATCTTGGAACAGT
GCGTCACCATAGTGCTGGATTTTGGCGGCATTCTGGAGGGGGAGCTTGATCTGTGCCGAGAGGCTCTAACAATGGTTCTCCAGGAGCAGG
TGGCTCACATAACCGAGTTCAATATCATACGGGTTTCTCAAGAGCCTGTGAAGTGGCAGGAAAATGCTACTCCTGTGACCGAACAGTCCA
TAGCTACTGCCATCAGTTGGGTTGAGAAACTGACGGTTGAGCTGACTGTGAGCGAGGCTGGCCGCCTGGATGCTCTGCTGGAAGCCGGGA
GAGACAAGACTATTGAATCCATTTACTACTTTGTGGTGGGGGATGTTCCTGAAGAATCCAAGGAGCTTCTCCTCCAGAGGGCCTTGGAGA
TCCCGTGTCCAGTCTACACAGTGTCCTTCAACGCCAGAGGAGAAGGCACTATAGCTTTTCTAAAGGATCTGAGTGCCAAGACCCACAGCA
GATTCCACGCATTTGCCGAGAGAACAGAGTGTGTAGAATTTCCTGCATTCTCCACAAAGGATGGTGACAATGTGATGACTTGGAATTCAA
GGAAACTGAAAGGAAAACTCCCTCCAGGAGCTGGAGTCAGAGAGGACGTGTTTCTCGTTTGGCAAGAGATGGAGGAAGCCTGCAGCACGC
TGGCCCAGATCCAGAGGCTGGTGGCCGAGCCTCCCAAGCCCGACGTGGCCACTGTGGACTGCGAGTCAGAAACAACCTCTGTTGAGATTG
CATCGAATCCAGAAGACACCTGGGACTCTAAGACATGGCTGCAGAAATATGGCTTGAAGGCCCAGAAGCTATCCTTGTATGATGTGCTTG
CCGACTGCTCTTTCCGCCACGCTGATGGGGTTGTGGATATAAAAGCCAAACCGGAGAATGAGTCCGTGCAGACCAGTGCGGAGACGAACA
AGAAGACAGTCCATGCAAAATATTGCAGCAGGTTTGTCCATGCTCCCTGGAAGGATGGGAGCTTGGTCCACGTCAACATTACCAAAGAGA
AGTGCAAGTGGTACAGTGAGAGAATCCACACAGCCCTGGCCCGGATCCGAAGGAGGATTAAATGGCTACAGGATGGGAGTCAAAGCCTCT
TTGGAAGATTGCATAATGATTGCATCTACATTCTCATTGACACGTCTCACTCAATGAAGAGCAAACTGGACTTGGTGAAGGACAAGATCA
TTCAGTTCATACAGGAACAGCTGAAATATAAAAGTAAGTTTAACTTTGTGAAGTTTGATGGTCAAGCAGTTGCTTGGCGGGAACAACTTG
CTGAAGTCAATGAAGATAATTTGGAACAGGCTCAGTCCTGGATTAGAGACATAAAGATTGGAAGCTCCACAAACACCCTGAGTGCCCTGA
AAACTGCTTTTGCTGATAAAGAAACACAGGCAATCTACCTTCTGACCGATGGGAGACCTGATCAGCCACCTGAAACAGTTATAGACCAGG
TCAAACGTTTTCAGGAAATTCCTATTTATACCATCTCCTTCAATTACAATGATGAGATTGCAAACAGGTTTTTGAAAGAGGTTGCTGCTT
TGACTGGAGGAGAGTTCCATTTTTATAATTTTGGTTGCAAGGATCCCACTCCCCCAGAGGCTGTTCAGAATGAAGATCTGACTCTTTTAG
TTAAGGAAATGGAACAGGGTCACAGTGATCTGGAGAAGATGCAAGACCTTTATTCTGAGTCCTTGATCATGGACTGGTGGTACAATGCAG
AAAAGGATGGAGACAGCAAGCATCAAAAGGAAATCTGTTCTATGATTTCAACCCCAGAAAAGTGTGCAAAGCCTCAATCTGATGTCGATT
CAACACAAACTTCATCTCTGAATATGTTGAAGGGACCATGGGGCCTTTCAGATCAAAAGGTTCAGAAAAAGAAAGTCCTTCACGCAGAAT
CAACCAAAACCAGCCTGCTCAGAAGCCAGATGTCCTCCCTCAGGAGCTCAGCTTGCAGTGAAAGGAAGGATGGCCTCTCCAATGCCAGCA
GCCGGAGGACTGCTCTAAGTGACAAAGAAATGAGCATCTTGCTGGCTGAGGAGTGGCTGGATGACAAATCGTCAGAAAAGGTGACGCGAG
AAGGAAGCCAGGTTTATGACCACGATTCTTCAGATGTGTCTTCAGAAAACTGGCTGAAGACCTATGGCTTGGTCGCCAAGAAACTCACCC
TCATGGATGCCTTGTCAGTGGCAGCAGTCCCGCACAGCTCCACCTATGTTCCCGTCCTGGACAAGCATGTCGTGTCTAAGGTCTTTGATG
AGGTGTTCCCTCTGGCACATGTGTGCAACGACACAAATAAGATGACATTAATTAACCCCCAAGGAGCCAAACTCAATATCTACAAGCGAA
AAGTGGAACAGGCAATTCAATCCTATGAAAAGCGCTTGAATAAAATTGTTTGGCGAGCATTATCTCAAGAGGAAAAAGAAAAGTTAGATG
CAAACAAACCAATACAGTACTTGGAAAACAAAACAGTTTTAAACCAGGCTTTAGAACGGTTGAATTGGCCCATTTCACTGAAAGAGCTGT
CGATGCTGGAAAGTGAAATCCTAGCTGGGAAAATGTACATCCAGCAGGCCATGGAACTCCAGGAGGCTGCCAAGAAGAATTATGCAAACA
AGGCCCCGGGAGAGCAACAGAAATTGCAAGGAAATCCAACAAAGAAAACCAAATCAAAAAGACCAGATCCCCTCAAAGGACAGAAGGTTA
TTGCAAGATGTGATGAAAATGGCTTTTATTTTCCAGGGGTTGTGAAGAAGTGTGTGAGCCGCACCCAAGCACTGGTGGGCTTCAGTTACG
GAGACACCAAGGTCGTGTCCACCTCCTTCATCACGCCTGTGGGGGGCGCCATGCCCTGCCCGCTGCTCCAGGTTGGAGATTATGTGTTTG
CCAAAATTGTGATACCCAAAGGATTTGACTTCTATGTCCCTGCCATTGTCATAGCACTTCCCAATAAGCATGTGGCCACAGAAAAATTCT
ACACAGTTTTGAAGTGTAACAACCGGAGAGAATTTTGCCCTCGGAGTGCACTTATTAAGATCAGCCAAAACAAGTATGCGCTCTCTTGCT
CTCATATAAAGTCACCCCCAATTCCTGAGGATCCAGAAGTAGAGGATGTGGAGGCGAGGAACTCTGCTTTCCTCTTCTGGCCACTGAAAG
AAGCGGACACGCAGGATTCCAGAGAGCCAAGACGAGAGAAGCCCAGGAGGAAAAAGAGGCCCGCCAAGCAGCCACTCCAGCAGGCGGCGC
CCTCGGACTCGGACGGCTCCTCCCACGGCATCAGCTCCCATGGGTCCTGCCAGGGGACACACCCCGAGCCCAGGACAGCCCACCTCCACT
TCCCCGCGGCCGGGCGTCTAGGACTCAGCAGCCACGCCATCATTGCCACACCTCCACCTCGAGCAGCCCTGCCCTGTACTCTCCAAGCCA
CCCACAGCAGCAAAGGGCTGAGGAGCGTCCCTGAGACACTTTAAGGCCGTCTGGTGGCAGCTATGTTTAAGAGACCAGCGTCCTTCCAGG
CTGTTCAGACCTCAGCGTTGACACTGAAACTGGCCCCTCCGCGGAGGTAAGGCCGCCCTCCGCGCCGCCTATGCCTGCCCTGTCTGTAGC
AAAGACTCCTCTCCCCTCCATCCCTGCTGCCTCCCCTACCCGTTTGACGACTTGGTTCTGGCTTTTTCTGACTGTTCTTTATCCTGTTTT
CCCCCTGCACTCACAAAATTGTATTCCATCTTCTGGTAGACGCCCCACCCCCAGAAGTTTTAACCTGAAGGATGACTGTCACAGGACTTT

>In-frame_ENST00000392133_ENST00000477737_TCGA-25-2392_XRCC5_chr2_217026771_+_VWA3B_chr2_98732114_length(amino acids)=1970AA_start in transcript=71_stop in transcript=5983
MDRTRRETRTTDKICVSGGSNTTRSRLRRNGENVRMLGGNLRMLGGNLRMLGENLRMLGRNLRELGGNLRKLGGNLRMLRVPGHGFPAPF
RPSRKRSGSFRYLPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAEN
KDEIALVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSS
RFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSES
LRKLCVFKKIERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDI
VPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFP
HIKHNYECLVYVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALH
PREPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIKTLFPLIEAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVG
SVNPAENFRVLVKQKKASFEEDYVASLGRPVASRYADGLFPQLYRAEDGRVYNLTAKSELIYQFVEHLTQAVESYKQRMDWLTSKSRQIF
GVILEQCVTIVLDFGGILEGELDLCREALTMVLQEQVAHITEFNIIRVSQEPVKWQENATPVTEQSIATAISWVEKLTVELTVSEAGRLD
ALLEAGRDKTIESIYYFVVGDVPEESKELLLQRALEIPCPVYTVSFNARGEGTIAFLKDLSAKTHSRFHAFAERTECVEFPAFSTKDGDN
VMTWNSRKLKGKLPPGAGVREDVFLVWQEMEEACSTLAQIQRLVAEPPKPDVATVDCESETTSVEIASNPEDTWDSKTWLQKYGLKAQKL
SLYDVLADCSFRHADGVVDIKAKPENESVQTSAETNKKTVHAKYCSRFVHAPWKDGSLVHVNITKEKCKWYSERIHTALARIRRRIKWLQ
DGSQSLFGRLHNDCIYILIDTSHSMKSKLDLVKDKIIQFIQEQLKYKSKFNFVKFDGQAVAWREQLAEVNEDNLEQAQSWIRDIKIGSST
NTLSALKTAFADKETQAIYLLTDGRPDQPPETVIDQVKRFQEIPIYTISFNYNDEIANRFLKEVAALTGGEFHFYNFGCKDPTPPEAVQN
EDLTLLVKEMEQGHSDLEKMQDLYSESLIMDWWYNAEKDGDSKHQKEICSMISTPEKCAKPQSDVDSTQTSSLNMLKGPWGLSDQKVQKK
KVLHAESTKTSLLRSQMSSLRSSACSERKDGLSNASSRRTALSDKEMSILLAEEWLDDKSSEKVTREGSQVYDHDSSDVSSENWLKTYGL
VAKKLTLMDALSVAAVPHSSTYVPVLDKHVVSKVFDEVFPLAHVCNDTNKMTLINPQGAKLNIYKRKVEQAIQSYEKRLNKIVWRALSQE
EKEKLDANKPIQYLENKTVLNQALERLNWPISLKELSMLESEILAGKMYIQQAMELQEAAKKNYANKAPGEQQKLQGNPTKKTKSKRPDP
LKGQKVIARCDENGFYFPGVVKKCVSRTQALVGFSYGDTKVVSTSFITPVGGAMPCPLLQVGDYVFAKIVIPKGFDFYVPAIVIALPNKH
VATEKFYTVLKCNNRREFCPRSALIKISQNKYALSCSHIKSPPIPEDPEVEDVEARNSAFLFWPLKEADTQDSREPRREKPRRKKRPAKQ

--------------------------------------------------------------
>In-frame_ENST00000392132_ENST00000435344_TCGA-25-2392_XRCC5_chr2_217026771_+_VWA3B_chr2_98732114_length(transcript)=3653nt_BP=1974nt
ACGGTTTCCCCGCCCCTTTCAGGCCTAGCAGGAAACGAAGCGGCTCTTTCCGCTATCTGCCGCTTGTCCACCGGAAGCGAGTTGCGACAC
GGCAGGTTCCCGCCCGGAAGAAGCGACCAAAGCGCCTGAGGACCGGCAACATGGTGCGGTCGGGGAATAAGGCAGCTGTTGTGCTGTGTA
TGGACGTGGGCTTTACCATGAGTAACTCCATTCCTGGTATAGAATCCCCATTTGAACAAGCAAAGAAGGTGATAACCATGTTTGTACAGC
GACAGGTGTTTGCTGAGAACAAGGATGAGATTGCTTTAGTCCTGTTTGGTACAGATGGCACTGACAATCCCCTTTCTGGTGGGGATCAGT
ATCAGAACATCACAGTGCACAGACATCTGATGCTACCAGATTTTGATTTGCTGGAGGACATTGAAAGCAAAATCCAACCAGGTTCTCAAC
AGGCTGACTTCCTGGATGCACTAATCGTGAGCATGGATGTGATTCAACATGAAACAATAGGAAAGAAGTTTGAGAAGAGGCATATTGAAA
TATTCACTGACCTCAGCAGCCGATTCAGCAAAAGTCAGCTGGATATTATAATTCATAGCTTGAAGAAATGTGACATCTCCCTGCAATTCT
TCTTGCCTTTCTCACTTGGCAAGGAAGATGGAAGTGGGGACAGAGGAGATGGCCCCTTTCGCTTAGGTGGCCATGGGCCTTCCTTTCCAC
TAAAAGGAATTACCGAACAGCAAAAAGAAGGTCTTGAGATAGTGAAAATGGTGATGATATCTTTAGAAGGTGAAGATGGGTTGGATGAAA
TTTATTCATTCAGTGAGAGTCTGAGAAAACTGTGCGTCTTCAAGAAAATTGAGAGGCATTCCATTCACTGGCCCTGCCGACTGACCATTG
GCTCCAATTTGTCTATAAGGATTGCAGCCTATAAATCGATTCTACAGGAGAGAGTTAAAAAGACTTGGACAGTTGTGGATGCAAAAACCC
TAAAAAAAGAAGATATACAAAAAGAAACAGTTTATTGCTTAAATGATGATGATGAAACTGAAGTTTTAAAAGAGGATATTATTCAAGGGT
TCCGCTATGGAAGTGATATAGTTCCTTTCTCTAAAGTGGATGAGGAACAAATGAAATATAAATCGGAGGGGAAGTGCTTCTCTGTTTTGG
GATTTTGTAAATCTTCTCAGGTTCAGAGAAGATTCTTCATGGGAAATCAAGTTCTAAAGGTCTTTGCAGCAAGAGATGATGAGGCAGCTG
CAGTTGCACTTTCCTCCCTGATTCATGCTTTGGATGACTTAGACATGGTGGCCATAGTTCGATATGCTTATGACAAAAGAGCTAATCCTC
AAGTCGGCGTGGCTTTTCCTCATATCAAGCATAACTATGAGTGTTTAGTGTATGTGCAGCTGCCTTTCATGGAAGACTTGCGGCAATACA
TGTTTTCATCCTTGAAAAACAGTAAGAAATATGCTCCCACCGAGGCACAGTTGAATGCTGTTGATGCTTTGATTGACTCCATGAGCTTGG
CAAAGAAAGATGAGAAGACAGACACCCTTGAAGACTTGTTTCCAACCACCAAAATCCCAAATCCTCGATTTCAGAGATTATTTCAGTGTC
TGCTGCACAGAGCTTTACATCCCCGGGAGCCTCTACCCCCAATTCAGCAGCATATTTGGAATATGCTGAATCCTCCCGCTGAGGTGACAA
CAAAAAGTCAGATTCCTCTCTCTAAAATAAAGACCCTTTTTCCTCTGATTGAAGCCAAGAAAAAGGATCAAGTGACTGCTCAGGAAATTT
TCCAAGACAACCATGAAGATGGACCTACAGCTAAAAAATTAAAGACTGAGCAAGGGGGAGCCCACTTCAGCGTCTCCAGTCTGGCTGAAG
GCAGTGTCACCTCTGTTGGAAGTGTGAATCCTGCTGAAAACTTCCGTGTTCTAGTGAAACAGAAGAAGGCCAGCTTTGAGGAAGATTATG
TGGCGTCTCTGGGGAGACCTGTGGCTTCTCGGTATGCTGATGGTCTGTTTCCACAGCTCTACAGAGCAGAAGATGGCAGAGTATACAATC
TGACAGCTAAATCAGAACTGATTTATCAGTTTGTGGAACATTTAACACAAGCTGTGGAGAGCTACAAGCAGCGAATGGACTGGCTCACCA
GCAAGAGCCGGCAGATTTTTGGTGTCATCTTGGAACAGTGCGTCACCATAGTGCTGGATTTTGGCGGCATTCTGGAGGGGGAGCTTGATC
TGTGCCGAGAGGCTCTAACAATGGTTCTCCAGGAGCAGGTGGCTCACATAACCGAGTTCAATATCATACGGGTTTCTCAAGAGCCTGTGA
AGTGGCAGGAAAATGCTACTCCTGTGACCGAACAGTCCATAGCTACTGCCATCAGTTGGGTTGAGAAACTGACGGTTGAGCTGACTGTGA
GCGAGGCTGGCCGCCTGGATGCTCTGCTGGAAGCCGGGAGAGACAAGACTATTGAATCCATTTACTACTTTGTGGTGGGGGATGTTCCTG
AAGAATCCAAGGAGCTTCTCCTCCAGAGGGCCTTGGAGATCCCGTGTCCAGTCTACACAGTGTCCTTCAACGCCAGAGGAGAAGGCACTA
TAGCTTTTCTAAAGGATCTGAGTGCCAAGACCCACAGCAGATTCCACGCATTTGCCGAGAGAACAGAGTGTGTAGAATTTCCTGCATTCT
CCACAAAGGATGGTGACAATGTGATGACTTGGAATTCAAGGAAACTGAAAGGAAAACTCCCTCCAGGAGCTGGAGTCAGAGAGGACGTGT
TTCTCGTTTGGCAAGAGATGGAGGAAGCCTGCAGCACGCTGGCCCAGATCCAGAGGCTGGTGGCCGAGCCTCCCAAGCCCGACGTGGCCA
CTGTGGACTGCGAGTCAGAAACAACCTCTGTTGAGATTGCATCGAATCCAGAAGACACCTGGGACTCTAAGACATGGCTGCAGAAATATG
GCTTGAAGGCCCAGAAGCTATCCTTGTATGATGTGCTTGCCGACTGCTCTTTCCGCCACGCTGATGGGGTTGTGGATATAAAAGCCAAAC
CGGAGAATGAGTCCGTGCAGACCAGTGCGGAGACGAACAAGAAGACAGTCCATGCAAAATATTGCAGCAGGTTTGTCCATGCTCCCTGGA
AGGATGGGAGCTTGGTCCACGTCAACATTACCAAAGAGAAGTGCAAGTGGTACAGTGAGAGAATCCACACAGCCCTGGCCCGGATCCGAA
GGAGGATTAAATGGCTACAGGATGGGAGTCAAAGCCTCTTTGGAAGATTGCATAATGATTGCATCTACATTCTCATTGACACGTCTCACT
CAATGAAGAGCAAACTGGACTTGGTGAAGGACAAGATCATTCAGTTCATACAGGAACAGCTGAAATATAAAAGTAAGTTTAACTTTGTGA
AGTTTGATGGTCAAGCAGTTGCTTGGCGGGAACAACTTGCTGAAGTCAATGAAGATAATTTGGAACAGGCTCAGTCCTGGATTAGAGACA
TAAAGATTGGAAGCTCCACAAACACCCTGAGTGCCCTGAAAACTGCTTTTGCTGATAAAGAAACACAGGCAATCTACCTTCTGACCGATG

>In-frame_ENST00000392132_ENST00000435344_TCGA-25-2392_XRCC5_chr2_217026771_+_VWA3B_chr2_98732114_length(amino acids)=1199AA_start in transcript=56_stop in transcript=3652
MPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTD
GTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIH
SLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIER
HSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDIVPFSKVDEEQMK
YKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNYECLVYV
QLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQHI
WNMLNPPAEVTTKSQIPLSKIKTLFPLIEAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNPAENFRVLV
KQKKASFEEDYVASLGRPVASRYADGLFPQLYRAEDGRVYNLTAKSELIYQFVEHLTQAVESYKQRMDWLTSKSRQIFGVILEQCVTIVL
DFGGILEGELDLCREALTMVLQEQVAHITEFNIIRVSQEPVKWQENATPVTEQSIATAISWVEKLTVELTVSEAGRLDALLEAGRDKTIE
SIYYFVVGDVPEESKELLLQRALEIPCPVYTVSFNARGEGTIAFLKDLSAKTHSRFHAFAERTECVEFPAFSTKDGDNVMTWNSRKLKGK
LPPGAGVREDVFLVWQEMEEACSTLAQIQRLVAEPPKPDVATVDCESETTSVEIASNPEDTWDSKTWLQKYGLKAQKLSLYDVLADCSFR
HADGVVDIKAKPENESVQTSAETNKKTVHAKYCSRFVHAPWKDGSLVHVNITKEKCKWYSERIHTALARIRRRIKWLQDGSQSLFGRLHN
DCIYILIDTSHSMKSKLDLVKDKIIQFIQEQLKYKSKFNFVKFDGQAVAWREQLAEVNEDNLEQAQSWIRDIKIGSSTNTLSALKTAFAD

--------------------------------------------------------------
>In-frame_ENST00000392132_ENST00000477737_TCGA-25-2392_XRCC5_chr2_217026771_+_VWA3B_chr2_98732114_length(transcript)=6028nt_BP=1974nt
ACGGTTTCCCCGCCCCTTTCAGGCCTAGCAGGAAACGAAGCGGCTCTTTCCGCTATCTGCCGCTTGTCCACCGGAAGCGAGTTGCGACAC
GGCAGGTTCCCGCCCGGAAGAAGCGACCAAAGCGCCTGAGGACCGGCAACATGGTGCGGTCGGGGAATAAGGCAGCTGTTGTGCTGTGTA
TGGACGTGGGCTTTACCATGAGTAACTCCATTCCTGGTATAGAATCCCCATTTGAACAAGCAAAGAAGGTGATAACCATGTTTGTACAGC
GACAGGTGTTTGCTGAGAACAAGGATGAGATTGCTTTAGTCCTGTTTGGTACAGATGGCACTGACAATCCCCTTTCTGGTGGGGATCAGT
ATCAGAACATCACAGTGCACAGACATCTGATGCTACCAGATTTTGATTTGCTGGAGGACATTGAAAGCAAAATCCAACCAGGTTCTCAAC
AGGCTGACTTCCTGGATGCACTAATCGTGAGCATGGATGTGATTCAACATGAAACAATAGGAAAGAAGTTTGAGAAGAGGCATATTGAAA
TATTCACTGACCTCAGCAGCCGATTCAGCAAAAGTCAGCTGGATATTATAATTCATAGCTTGAAGAAATGTGACATCTCCCTGCAATTCT
TCTTGCCTTTCTCACTTGGCAAGGAAGATGGAAGTGGGGACAGAGGAGATGGCCCCTTTCGCTTAGGTGGCCATGGGCCTTCCTTTCCAC
TAAAAGGAATTACCGAACAGCAAAAAGAAGGTCTTGAGATAGTGAAAATGGTGATGATATCTTTAGAAGGTGAAGATGGGTTGGATGAAA
TTTATTCATTCAGTGAGAGTCTGAGAAAACTGTGCGTCTTCAAGAAAATTGAGAGGCATTCCATTCACTGGCCCTGCCGACTGACCATTG
GCTCCAATTTGTCTATAAGGATTGCAGCCTATAAATCGATTCTACAGGAGAGAGTTAAAAAGACTTGGACAGTTGTGGATGCAAAAACCC
TAAAAAAAGAAGATATACAAAAAGAAACAGTTTATTGCTTAAATGATGATGATGAAACTGAAGTTTTAAAAGAGGATATTATTCAAGGGT
TCCGCTATGGAAGTGATATAGTTCCTTTCTCTAAAGTGGATGAGGAACAAATGAAATATAAATCGGAGGGGAAGTGCTTCTCTGTTTTGG
GATTTTGTAAATCTTCTCAGGTTCAGAGAAGATTCTTCATGGGAAATCAAGTTCTAAAGGTCTTTGCAGCAAGAGATGATGAGGCAGCTG
CAGTTGCACTTTCCTCCCTGATTCATGCTTTGGATGACTTAGACATGGTGGCCATAGTTCGATATGCTTATGACAAAAGAGCTAATCCTC
AAGTCGGCGTGGCTTTTCCTCATATCAAGCATAACTATGAGTGTTTAGTGTATGTGCAGCTGCCTTTCATGGAAGACTTGCGGCAATACA
TGTTTTCATCCTTGAAAAACAGTAAGAAATATGCTCCCACCGAGGCACAGTTGAATGCTGTTGATGCTTTGATTGACTCCATGAGCTTGG
CAAAGAAAGATGAGAAGACAGACACCCTTGAAGACTTGTTTCCAACCACCAAAATCCCAAATCCTCGATTTCAGAGATTATTTCAGTGTC
TGCTGCACAGAGCTTTACATCCCCGGGAGCCTCTACCCCCAATTCAGCAGCATATTTGGAATATGCTGAATCCTCCCGCTGAGGTGACAA
CAAAAAGTCAGATTCCTCTCTCTAAAATAAAGACCCTTTTTCCTCTGATTGAAGCCAAGAAAAAGGATCAAGTGACTGCTCAGGAAATTT
TCCAAGACAACCATGAAGATGGACCTACAGCTAAAAAATTAAAGACTGAGCAAGGGGGAGCCCACTTCAGCGTCTCCAGTCTGGCTGAAG
GCAGTGTCACCTCTGTTGGAAGTGTGAATCCTGCTGAAAACTTCCGTGTTCTAGTGAAACAGAAGAAGGCCAGCTTTGAGGAAGATTATG
TGGCGTCTCTGGGGAGACCTGTGGCTTCTCGGTATGCTGATGGTCTGTTTCCACAGCTCTACAGAGCAGAAGATGGCAGAGTATACAATC
TGACAGCTAAATCAGAACTGATTTATCAGTTTGTGGAACATTTAACACAAGCTGTGGAGAGCTACAAGCAGCGAATGGACTGGCTCACCA
GCAAGAGCCGGCAGATTTTTGGTGTCATCTTGGAACAGTGCGTCACCATAGTGCTGGATTTTGGCGGCATTCTGGAGGGGGAGCTTGATC
TGTGCCGAGAGGCTCTAACAATGGTTCTCCAGGAGCAGGTGGCTCACATAACCGAGTTCAATATCATACGGGTTTCTCAAGAGCCTGTGA
AGTGGCAGGAAAATGCTACTCCTGTGACCGAACAGTCCATAGCTACTGCCATCAGTTGGGTTGAGAAACTGACGGTTGAGCTGACTGTGA
GCGAGGCTGGCCGCCTGGATGCTCTGCTGGAAGCCGGGAGAGACAAGACTATTGAATCCATTTACTACTTTGTGGTGGGGGATGTTCCTG
AAGAATCCAAGGAGCTTCTCCTCCAGAGGGCCTTGGAGATCCCGTGTCCAGTCTACACAGTGTCCTTCAACGCCAGAGGAGAAGGCACTA
TAGCTTTTCTAAAGGATCTGAGTGCCAAGACCCACAGCAGATTCCACGCATTTGCCGAGAGAACAGAGTGTGTAGAATTTCCTGCATTCT
CCACAAAGGATGGTGACAATGTGATGACTTGGAATTCAAGGAAACTGAAAGGAAAACTCCCTCCAGGAGCTGGAGTCAGAGAGGACGTGT
TTCTCGTTTGGCAAGAGATGGAGGAAGCCTGCAGCACGCTGGCCCAGATCCAGAGGCTGGTGGCCGAGCCTCCCAAGCCCGACGTGGCCA
CTGTGGACTGCGAGTCAGAAACAACCTCTGTTGAGATTGCATCGAATCCAGAAGACACCTGGGACTCTAAGACATGGCTGCAGAAATATG
GCTTGAAGGCCCAGAAGCTATCCTTGTATGATGTGCTTGCCGACTGCTCTTTCCGCCACGCTGATGGGGTTGTGGATATAAAAGCCAAAC
CGGAGAATGAGTCCGTGCAGACCAGTGCGGAGACGAACAAGAAGACAGTCCATGCAAAATATTGCAGCAGGTTTGTCCATGCTCCCTGGA
AGGATGGGAGCTTGGTCCACGTCAACATTACCAAAGAGAAGTGCAAGTGGTACAGTGAGAGAATCCACACAGCCCTGGCCCGGATCCGAA
GGAGGATTAAATGGCTACAGGATGGGAGTCAAAGCCTCTTTGGAAGATTGCATAATGATTGCATCTACATTCTCATTGACACGTCTCACT
CAATGAAGAGCAAACTGGACTTGGTGAAGGACAAGATCATTCAGTTCATACAGGAACAGCTGAAATATAAAAGTAAGTTTAACTTTGTGA
AGTTTGATGGTCAAGCAGTTGCTTGGCGGGAACAACTTGCTGAAGTCAATGAAGATAATTTGGAACAGGCTCAGTCCTGGATTAGAGACA
TAAAGATTGGAAGCTCCACAAACACCCTGAGTGCCCTGAAAACTGCTTTTGCTGATAAAGAAACACAGGCAATCTACCTTCTGACCGATG
GGAGACCTGATCAGCCACCTGAAACAGTTATAGACCAGGTCAAACGTTTTCAGGAAATTCCTATTTATACCATCTCCTTCAATTACAATG
ATGAGATTGCAAACAGGTTTTTGAAAGAGGTTGCTGCTTTGACTGGAGGAGAGTTCCATTTTTATAATTTTGGTTGCAAGGATCCCACTC
CCCCAGAGGCTGTTCAGAATGAAGATCTGACTCTTTTAGTTAAGGAAATGGAACAGGGTCACAGTGATCTGGAGAAGATGCAAGACCTTT
ATTCTGAGTCCTTGATCATGGACTGGTGGTACAATGCAGAAAAGGATGGAGACAGCAAGCATCAAAAGGAAATCTGTTCTATGATTTCAA
CCCCAGAAAAGTGTGCAAAGCCTCAATCTGATGTCGATTCAACACAAACTTCATCTCTGAATATGTTGAAGGGACCATGGGGCCTTTCAG
ATCAAAAGGTTCAGAAAAAGAAAGTCCTTCACGCAGAATCAACCAAAACCAGCCTGCTCAGAAGCCAGATGTCCTCCCTCAGGAGCTCAG
CTTGCAGTGAAAGGAAGGATGGCCTCTCCAATGCCAGCAGCCGGAGGACTGCTCTAAGTGACAAAGAAATGAGCATCTTGCTGGCTGAGG
AGTGGCTGGATGACAAATCGTCAGAAAAGGTGACGCGAGAAGGAAGCCAGGTTTATGACCACGATTCTTCAGATGTGTCTTCAGAAAACT
GGCTGAAGACCTATGGCTTGGTCGCCAAGAAACTCACCCTCATGGATGCCTTGTCAGTGGCAGCAGTCCCGCACAGCTCCACCTATGTTC
CCGTCCTGGACAAGCATGTCGTGTCTAAGGTCTTTGATGAGGTGTTCCCTCTGGCACATGTGTGCAACGACACAAATAAGATGACATTAA
TTAACCCCCAAGGAGCCAAACTCAATATCTACAAGCGAAAAGTGGAACAGGCAATTCAATCCTATGAAAAGCGCTTGAATAAAATTGTTT
GGCGAGCATTATCTCAAGAGGAAAAAGAAAAGTTAGATGCAAACAAACCAATACAGTACTTGGAAAACAAAACAGTTTTAAACCAGGCTT
TAGAACGGTTGAATTGGCCCATTTCACTGAAAGAGCTGTCGATGCTGGAAAGTGAAATCCTAGCTGGGAAAATGTACATCCAGCAGGCCA
TGGAACTCCAGGAGGCTGCCAAGAAGAATTATGCAAACAAGGCCCCGGGAGAGCAACAGAAATTGCAAGGAAATCCAACAAAGAAAACCA
AATCAAAAAGACCAGATCCCCTCAAAGGACAGAAGGTTATTGCAAGATGTGATGAAAATGGCTTTTATTTTCCAGGGGTTGTGAAGAAGT
GTGTGAGCCGCACCCAAGCACTGGTGGGCTTCAGTTACGGAGACACCAAGGTCGTGTCCACCTCCTTCATCACGCCTGTGGGGGGCGCCA
TGCCCTGCCCGCTGCTCCAGGTTGGAGATTATGTGTTTGCCAAAATTGTGATACCCAAAGGATTTGACTTCTATGTCCCTGCCATTGTCA
TAGCACTTCCCAATAAGCATGTGGCCACAGAAAAATTCTACACAGTTTTGAAGTGTAACAACCGGAGAGAATTTTGCCCTCGGAGTGCAC
TTATTAAGATCAGCCAAAACAAGTATGCGCTCTCTTGCTCTCATATAAAGTCACCCCCAATTCCTGAGGATCCAGAAGTAGAGGATGTGG
AGGCGAGGAACTCTGCTTTCCTCTTCTGGCCACTGAAAGAAGCGGACACGCAGGATTCCAGAGAGCCAAGACGAGAGAAGCCCAGGAGGA
AAAAGAGGCCCGCCAAGCAGCCACTCCAGCAGGCGGCGCCCTCGGACTCGGACGGCTCCTCCCACGGCATCAGCTCCCATGGGTCCTGCC
AGGGGACACACCCCGAGCCCAGGACAGCCCACCTCCACTTCCCCGCGGCCGGGCGTCTAGGACTCAGCAGCCACGCCATCATTGCCACAC
CTCCACCTCGAGCAGCCCTGCCCTGTACTCTCCAAGCCACCCACAGCAGCAAAGGGCTGAGGAGCGTCCCTGAGACACTTTAAGGCCGTC
TGGTGGCAGCTATGTTTAAGAGACCAGCGTCCTTCCAGGCTGTTCAGACCTCAGCGTTGACACTGAAACTGGCCCCTCCGCGGAGGTAAG
GCCGCCCTCCGCGCCGCCTATGCCTGCCCTGTCTGTAGCAAAGACTCCTCTCCCCTCCATCCCTGCTGCCTCCCCTACCCGTTTGACGAC
TTGGTTCTGGCTTTTTCTGACTGTTCTTTATCCTGTTTTCCCCCTGCACTCACAAAATTGTATTCCATCTTCTGGTAGACGCCCCACCCC

>In-frame_ENST00000392132_ENST00000477737_TCGA-25-2392_XRCC5_chr2_217026771_+_VWA3B_chr2_98732114_length(amino acids)=1868AA_start in transcript=56_stop in transcript=5662
MPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTD
GTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIH
SLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIER
HSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDIVPFSKVDEEQMK
YKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNYECLVYV
QLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQHI
WNMLNPPAEVTTKSQIPLSKIKTLFPLIEAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNPAENFRVLV
KQKKASFEEDYVASLGRPVASRYADGLFPQLYRAEDGRVYNLTAKSELIYQFVEHLTQAVESYKQRMDWLTSKSRQIFGVILEQCVTIVL
DFGGILEGELDLCREALTMVLQEQVAHITEFNIIRVSQEPVKWQENATPVTEQSIATAISWVEKLTVELTVSEAGRLDALLEAGRDKTIE
SIYYFVVGDVPEESKELLLQRALEIPCPVYTVSFNARGEGTIAFLKDLSAKTHSRFHAFAERTECVEFPAFSTKDGDNVMTWNSRKLKGK
LPPGAGVREDVFLVWQEMEEACSTLAQIQRLVAEPPKPDVATVDCESETTSVEIASNPEDTWDSKTWLQKYGLKAQKLSLYDVLADCSFR
HADGVVDIKAKPENESVQTSAETNKKTVHAKYCSRFVHAPWKDGSLVHVNITKEKCKWYSERIHTALARIRRRIKWLQDGSQSLFGRLHN
DCIYILIDTSHSMKSKLDLVKDKIIQFIQEQLKYKSKFNFVKFDGQAVAWREQLAEVNEDNLEQAQSWIRDIKIGSSTNTLSALKTAFAD
KETQAIYLLTDGRPDQPPETVIDQVKRFQEIPIYTISFNYNDEIANRFLKEVAALTGGEFHFYNFGCKDPTPPEAVQNEDLTLLVKEMEQ
GHSDLEKMQDLYSESLIMDWWYNAEKDGDSKHQKEICSMISTPEKCAKPQSDVDSTQTSSLNMLKGPWGLSDQKVQKKKVLHAESTKTSL
LRSQMSSLRSSACSERKDGLSNASSRRTALSDKEMSILLAEEWLDDKSSEKVTREGSQVYDHDSSDVSSENWLKTYGLVAKKLTLMDALS
VAAVPHSSTYVPVLDKHVVSKVFDEVFPLAHVCNDTNKMTLINPQGAKLNIYKRKVEQAIQSYEKRLNKIVWRALSQEEKEKLDANKPIQ
YLENKTVLNQALERLNWPISLKELSMLESEILAGKMYIQQAMELQEAAKKNYANKAPGEQQKLQGNPTKKTKSKRPDPLKGQKVIARCDE
NGFYFPGVVKKCVSRTQALVGFSYGDTKVVSTSFITPVGGAMPCPLLQVGDYVFAKIVIPKGFDFYVPAIVIALPNKHVATEKFYTVLKC
NNRREFCPRSALIKISQNKYALSCSHIKSPPIPEDPEVEDVEARNSAFLFWPLKEADTQDSREPRREKPRRKKRPAKQPLQQAAPSDSDG

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Fusion Gene PPI Analysis for XRCC5-VWA3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for XRCC5-VWA3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for XRCC5-VWA3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneXRCC5C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneXRCC5C0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneXRCC5C0678306alcohol sensitivity1PSYGENET
TgeneVWA3BC4310781SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 221UNIPROT