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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:YWHAE-SPNS3 (FusionGDB2 ID:99477)

Fusion Gene Summary for YWHAE-SPNS3

check button Fusion gene summary
Fusion gene informationFusion gene name: YWHAE-SPNS3
Fusion gene ID: 99477
HgeneTgene
Gene symbol

YWHAE

SPNS3

Gene ID

7531

201305

Gene nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilonsphingolipid transporter 3 (putative)
Synonyms14-3-3E|HEL2|KCIP-1|MDCR|MDSSLC62A3
Cytomap

17p13.3

17p13.2

Type of geneprotein-codingprotein-coding
Description14-3-3 protein epsilon14-3-3 epsilonepididymis luminal protein 2mitochondrial import stimulation factor L subunitprotein kinase C inhibitor protein-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptidetyrosine protein spinster homolog 3SPNS sphingolipid transporter 3 (putative)spinster homolog 3
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264335, ENST00000571732, 
ENST00000573026, ENST00000575977, 
ENST00000498643, 		ENST00000355530, 
ENST00000333476, ENST00000576069, 
Fusion gene scores* DoF score28 X 9 X 15=37804 X 2 X 3=24
# samples 428
** MAII scorelog2(42/3780*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/24*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: YWHAE [Title/Abstract] AND SPNS3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointYWHAE(1264386)-SPNS3(4381867), # samples:2
Anticipated loss of major functional domain due to fusion event.YWHAE-SPNS3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
YWHAE-SPNS3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
YWHAE-SPNS3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYWHAE

GO:0000165

MAPK cascade

12917326

HgeneYWHAE

GO:0034605

cellular response to heat

12917326

HgeneYWHAE

GO:0046827

positive regulation of protein export from nucleus

12917326

HgeneYWHAE

GO:0051480

regulation of cytosolic calcium ion concentration

18029012

HgeneYWHAE

GO:0060306

regulation of membrane repolarization

11953308

HgeneYWHAE

GO:1901016

regulation of potassium ion transmembrane transporter activity

11953308

HgeneYWHAE

GO:1901020

negative regulation of calcium ion transmembrane transporter activity

18029012

HgeneYWHAE

GO:1902309

negative regulation of peptidyl-serine dephosphorylation

11953308

HgeneYWHAE

GO:1905913

negative regulation of calcium ion export across plasma membrane

18029012


check buttonFusion gene breakpoints across YWHAE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SPNS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-80-5611-01AYWHAEchr17

1264386

-SPNS3chr17

4381867

+
ChimerDB4LUADTCGA-80-5611YWHAEchr17

1264385

-SPNS3chr17

4381866

+
ChimerDB4LUADTCGA-80-5611-01AYWHAEchr17

1264386

-SPNS3chr17

4381867

+


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Fusion Gene ORF analysis for YWHAE-SPNS3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000264335ENST00000355530YWHAEchr17

1264386

-SPNS3chr17

4381867

+
Frame-shiftENST00000264335ENST00000333476YWHAEchr17

1264386

-SPNS3chr17

4381867

+
5CDS-intronENST00000264335ENST00000576069YWHAEchr17

1264386

-SPNS3chr17

4381867

+
In-frameENST00000571732ENST00000355530YWHAEchr17

1264386

-SPNS3chr17

4381867

+
In-frameENST00000571732ENST00000333476YWHAEchr17

1264386

-SPNS3chr17

4381867

+
5CDS-intronENST00000571732ENST00000576069YWHAEchr17

1264386

-SPNS3chr17

4381867

+
intron-3CDSENST00000573026ENST00000355530YWHAEchr17

1264386

-SPNS3chr17

4381867

+
intron-3CDSENST00000573026ENST00000333476YWHAEchr17

1264386

-SPNS3chr17

4381867

+
intron-intronENST00000573026ENST00000576069YWHAEchr17

1264386

-SPNS3chr17

4381867

+
intron-3CDSENST00000575977ENST00000355530YWHAEchr17

1264386

-SPNS3chr17

4381867

+
intron-3CDSENST00000575977ENST00000333476YWHAEchr17

1264386

-SPNS3chr17

4381867

+
intron-intronENST00000575977ENST00000576069YWHAEchr17

1264386

-SPNS3chr17

4381867

+
intron-3CDSENST00000498643ENST00000355530YWHAEchr17

1264386

-SPNS3chr17

4381867

+
intron-3CDSENST00000498643ENST00000333476YWHAEchr17

1264386

-SPNS3chr17

4381867

+
intron-intronENST00000498643ENST00000576069YWHAEchr17

1264386

-SPNS3chr17

4381867

+
Frame-shiftENST00000264335ENST00000355530YWHAEchr17

1264385

-SPNS3chr17

4381866

+
Frame-shiftENST00000264335ENST00000333476YWHAEchr17

1264385

-SPNS3chr17

4381866

+
5CDS-intronENST00000264335ENST00000576069YWHAEchr17

1264385

-SPNS3chr17

4381866

+
In-frameENST00000571732ENST00000355530YWHAEchr17

1264385

-SPNS3chr17

4381866

+
In-frameENST00000571732ENST00000333476YWHAEchr17

1264385

-SPNS3chr17

4381866

+
5CDS-intronENST00000571732ENST00000576069YWHAEchr17

1264385

-SPNS3chr17

4381866

+
intron-3CDSENST00000573026ENST00000355530YWHAEchr17

1264385

-SPNS3chr17

4381866

+
intron-3CDSENST00000573026ENST00000333476YWHAEchr17

1264385

-SPNS3chr17

4381866

+
intron-intronENST00000573026ENST00000576069YWHAEchr17

1264385

-SPNS3chr17

4381866

+
intron-3CDSENST00000575977ENST00000355530YWHAEchr17

1264385

-SPNS3chr17

4381866

+
intron-3CDSENST00000575977ENST00000333476YWHAEchr17

1264385

-SPNS3chr17

4381866

+
intron-intronENST00000575977ENST00000576069YWHAEchr17

1264385

-SPNS3chr17

4381866

+
intron-3CDSENST00000498643ENST00000355530YWHAEchr17

1264385

-SPNS3chr17

4381866

+
intron-3CDSENST00000498643ENST00000333476YWHAEchr17

1264385

-SPNS3chr17

4381866

+
intron-intronENST00000498643ENST00000576069YWHAEchr17

1264385

-SPNS3chr17

4381866

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000571732YWHAEchr171264386-ENST00000355530SPNS3chr174381867+14617212091006265
ENST00000571732YWHAEchr171264386-ENST00000333476SPNS3chr174381867+14567212091006265
ENST00000571732YWHAEchr171264385-ENST00000355530SPNS3chr174381866+14617212091006265
ENST00000571732YWHAEchr171264385-ENST00000333476SPNS3chr174381866+14567212091006265

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000571732ENST00000355530YWHAEchr171264386-SPNS3chr174381867+0.084814650.91518533
ENST00000571732ENST00000333476YWHAEchr171264386-SPNS3chr174381867+0.087551570.9124484
ENST00000571732ENST00000355530YWHAEchr171264385-SPNS3chr174381866+0.084814650.91518533
ENST00000571732ENST00000333476YWHAEchr171264385-SPNS3chr174381866+0.087551570.9124484

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Fusion Genomic Features for YWHAE-SPNS3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
YWHAEchr171264385-SPNS3chr174381866+5.17E-081
YWHAEchr171264385-SPNS3chr174381866+5.17E-081
YWHAEchr171264385-SPNS3chr174381866+5.17E-081
YWHAEchr171264385-SPNS3chr174381866+5.17E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for YWHAE-SPNS3


check button Go to

FGviewer for the breakpoints of chr17:1264386-chr17:4381867

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSPNS3chr17:1264385chr17:4381866ENST00000333476611260_280244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST00000333476611309_329244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST00000333476611343_365244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST00000333476611377_397244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST00000333476611411_431244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST00000333476611450_470244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST00000355530712377_397371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST00000355530712411_431371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST00000355530712450_470371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST00000333476611260_280244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST00000333476611309_329244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST00000333476611343_365244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST00000333476611377_397244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST00000333476611411_431244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST00000333476611450_470244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST00000355530712377_397371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST00000355530712411_431371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST00000355530712450_470371.0513.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSPNS3chr17:1264385chr17:4381866ENST00000333476611112_132244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST00000333476611145_165244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST00000333476611173_193244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST00000333476611204_224244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST0000033347661150_70244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST0000033347661184_104244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST00000355530712112_132371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST00000355530712145_165371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST00000355530712173_193371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST00000355530712204_224371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST00000355530712260_280371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST00000355530712309_329371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST00000355530712343_365371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST0000035553071250_70371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264385chr17:4381866ENST0000035553071284_104371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST00000333476611112_132244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST00000333476611145_165244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST00000333476611173_193244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST00000333476611204_224244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST0000033347661150_70244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST0000033347661184_104244.0386.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST00000355530712112_132371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST00000355530712145_165371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST00000355530712173_193371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST00000355530712204_224371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST00000355530712260_280371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST00000355530712309_329371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST00000355530712343_365371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST0000035553071250_70371.0513.0TransmembraneHelical
TgeneSPNS3chr17:1264386chr17:4381867ENST0000035553071284_104371.0513.0TransmembraneHelical


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Fusion Gene Sequence for YWHAE-SPNS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000571732_ENST00000355530_TCGA-80-5611-01A_YWHAE_chr17_1264386_-_SPNS3_chr17_4381867_length(transcript)=1461nt_BP=721nt
ATTGAGGCGCCGCCATTTTTGCTGCCCGGACGCGGAGCGAGAGGCTGAGAGAGTCGGAGACACTATCCGCTTCCATCCGTCGCGCAGACC
CTGCCGGAGCCGCTGCCGCTATGGATGATCGAGAGGATCTGGTGTACCAGGCGAAGCTGGCCGAGCAGGCTGAGCGATACGACGTGCTCT
GGAACTGAACCCGCAGTATCTTCCAAGAAATGGTGGAGTCAATGAAGAAAGTAGCAGGGATGGATGTGGAGCTGACAGTTGAAGAAAGAA
ACCTCCTATCTGTTGCATATAAGAATGTGATTGGAGCTAGAAGAGCCTCCTGGAGAATAATCAGCAGCATTGAACAGAAAGAAGAAAACA
AGGGAGGAGAAGACAAGCTAAAAATGATTCGGGAATATCGGCAAATGGTTGAGACTGAGCTAAAGTTAATCTGTTGTGACATTCTGGATG
TACTGGACAAACACCTCATTCCAGCAGCTAACACTGGCGAGTCCAAGGTTTTCTATTATAAAATGAAAGGGGACTACCACAGGTATCTGG
CAGAATTTGCCACAGGAAACGACAGGAAGGAGGCTGCGGAGAACAGCCTAGTGGCTTATAAAGCTGCTAGTGATATTGCAATGACAGAAC
TTCCACCAACGCATCCTATTCGCTTAGGTCTTGCTCTCAATTTTTCCGTATTCTACTACGAAATTCTTAATTCCCCTGACCGTGCCTGCA
GGTGTTCCTGGGCCTTGGGGAGCTGCTTCTGTCCTGCAACTGGGCAGTGGTTGCCGACATCCTGCTGTCTGTGGTGGTGCCCAGATGCCG
GGGGACGGCAGAGGCACTTCAGATCACGGTGGGCCACATCCTGGGAGACGCTGGCAGCCCCTATCTCACAGGACTTATCTCTAGTGTCCT
GCGGGCCAGGCGCCCTGACTCCTATCTGCAGCGCTTCCGCAGCCTGCAGCAGAGCTTCCTGTGCTGCGCCTTTGTCATCGCCCTGGGGGG
CGGCTGCTTCCTGCTGACTGCGCTGTACCTGGAGAGAGACGAGACCCGGGCCTGGCAGCCTGTCACAGGGACCCCAGACAGCAATGATGT
GGACAGCAACGACCTGGAGAGACAAGGCCTACTTTCGGGCGCTGGCGCCTCTACAGAGGAGCCCTGAGGTCCCTGCCTACACTCGTCCTG
CCTGCAAGCCTCCCGTTGGTCCCCACAGCAGCAGTGCCTCGGTTCCTCTTTGGCTGTCCTCGGGGACTCCGGCTGAGGCACATCTGCCAC
TTTTGAATTCCCGGCTGGAGAGCTGGCAGGACCCTGTGGCTGGGCTGGGAATGGAGCTGTCAGCACTCTGCGTGGGAGGCCTGGGCCTGT
GCCTGCATCCCGCTCAAGGCTGCCCCAGCCTGGGGTCTCCAGCCTGGCTGCTGCTGGGCCCTGAATAAAGAGAGGCCAGTACAAAGCCCA

>In-frame_ENST00000571732_ENST00000355530_TCGA-80-5611-01A_YWHAE_chr17_1264386_-_SPNS3_chr17_4381867_length(amino acids)=265AA_start in transcript=209_stop in transcript=1006
MVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAA
NTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRCSWALGSCF

--------------------------------------------------------------
>In-frame_ENST00000571732_ENST00000333476_TCGA-80-5611-01A_YWHAE_chr17_1264386_-_SPNS3_chr17_4381867_length(transcript)=1456nt_BP=721nt
ATTGAGGCGCCGCCATTTTTGCTGCCCGGACGCGGAGCGAGAGGCTGAGAGAGTCGGAGACACTATCCGCTTCCATCCGTCGCGCAGACC
CTGCCGGAGCCGCTGCCGCTATGGATGATCGAGAGGATCTGGTGTACCAGGCGAAGCTGGCCGAGCAGGCTGAGCGATACGACGTGCTCT
GGAACTGAACCCGCAGTATCTTCCAAGAAATGGTGGAGTCAATGAAGAAAGTAGCAGGGATGGATGTGGAGCTGACAGTTGAAGAAAGAA
ACCTCCTATCTGTTGCATATAAGAATGTGATTGGAGCTAGAAGAGCCTCCTGGAGAATAATCAGCAGCATTGAACAGAAAGAAGAAAACA
AGGGAGGAGAAGACAAGCTAAAAATGATTCGGGAATATCGGCAAATGGTTGAGACTGAGCTAAAGTTAATCTGTTGTGACATTCTGGATG
TACTGGACAAACACCTCATTCCAGCAGCTAACACTGGCGAGTCCAAGGTTTTCTATTATAAAATGAAAGGGGACTACCACAGGTATCTGG
CAGAATTTGCCACAGGAAACGACAGGAAGGAGGCTGCGGAGAACAGCCTAGTGGCTTATAAAGCTGCTAGTGATATTGCAATGACAGAAC
TTCCACCAACGCATCCTATTCGCTTAGGTCTTGCTCTCAATTTTTCCGTATTCTACTACGAAATTCTTAATTCCCCTGACCGTGCCTGCA
GGTGTTCCTGGGCCTTGGGGAGCTGCTTCTGTCCTGCAACTGGGCAGTGGTTGCCGACATCCTGCTGTCTGTGGTGGTGCCCAGATGCCG
GGGGACGGCAGAGGCACTTCAGATCACGGTGGGCCACATCCTGGGAGACGCTGGCAGCCCCTATCTCACAGGACTTATCTCTAGTGTCCT
GCGGGCCAGGCGCCCTGACTCCTATCTGCAGCGCTTCCGCAGCCTGCAGCAGAGCTTCCTGTGCTGCGCCTTTGTCATCGCCCTGGGGGG
CGGCTGCTTCCTGCTGACTGCGCTGTACCTGGAGAGAGACGAGACCCGGGCCTGGCAGCCTGTCACAGGGACCCCAGACAGCAATGATGT
GGACAGCAACGACCTGGAGAGACAAGGCCTACTTTCGGGCGCTGGCGCCTCTACAGAGGAGCCCTGAGGTCCCTGCCTACACTCGTCCTG
CCTGCAAGCCTCCCGTTGGTCCCCACAGCAGCAGTGCCTCGGTTCCTCTTTGGCTGTCCTCGGGGACTCCGGCTGAGGCACATCTGCCAC
TTTTGAATTCCCGGCTGGAGAGCTGGCAGGACCCTGTGGCTGGGCTGGGAATGGAGCTGTCAGCACTCTGCGTGGGAGGCCTGGGCCTGT
GCCTGCATCCCGCTCAAGGCTGCCCCAGCCTGGGGTCTCCAGCCTGGCTGCTGCTGGGCCCTGAATAAAGAGAGGCCAGTACAAAGCCCA

>In-frame_ENST00000571732_ENST00000333476_TCGA-80-5611-01A_YWHAE_chr17_1264386_-_SPNS3_chr17_4381867_length(amino acids)=265AA_start in transcript=209_stop in transcript=1006
MVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAA
NTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRCSWALGSCF

--------------------------------------------------------------
>In-frame_ENST00000571732_ENST00000355530_TCGA-80-5611_YWHAE_chr17_1264385_-_SPNS3_chr17_4381866_length(transcript)=1461nt_BP=721nt
ATTGAGGCGCCGCCATTTTTGCTGCCCGGACGCGGAGCGAGAGGCTGAGAGAGTCGGAGACACTATCCGCTTCCATCCGTCGCGCAGACC
CTGCCGGAGCCGCTGCCGCTATGGATGATCGAGAGGATCTGGTGTACCAGGCGAAGCTGGCCGAGCAGGCTGAGCGATACGACGTGCTCT
GGAACTGAACCCGCAGTATCTTCCAAGAAATGGTGGAGTCAATGAAGAAAGTAGCAGGGATGGATGTGGAGCTGACAGTTGAAGAAAGAA
ACCTCCTATCTGTTGCATATAAGAATGTGATTGGAGCTAGAAGAGCCTCCTGGAGAATAATCAGCAGCATTGAACAGAAAGAAGAAAACA
AGGGAGGAGAAGACAAGCTAAAAATGATTCGGGAATATCGGCAAATGGTTGAGACTGAGCTAAAGTTAATCTGTTGTGACATTCTGGATG
TACTGGACAAACACCTCATTCCAGCAGCTAACACTGGCGAGTCCAAGGTTTTCTATTATAAAATGAAAGGGGACTACCACAGGTATCTGG
CAGAATTTGCCACAGGAAACGACAGGAAGGAGGCTGCGGAGAACAGCCTAGTGGCTTATAAAGCTGCTAGTGATATTGCAATGACAGAAC
TTCCACCAACGCATCCTATTCGCTTAGGTCTTGCTCTCAATTTTTCCGTATTCTACTACGAAATTCTTAATTCCCCTGACCGTGCCTGCA
GGTGTTCCTGGGCCTTGGGGAGCTGCTTCTGTCCTGCAACTGGGCAGTGGTTGCCGACATCCTGCTGTCTGTGGTGGTGCCCAGATGCCG
GGGGACGGCAGAGGCACTTCAGATCACGGTGGGCCACATCCTGGGAGACGCTGGCAGCCCCTATCTCACAGGACTTATCTCTAGTGTCCT
GCGGGCCAGGCGCCCTGACTCCTATCTGCAGCGCTTCCGCAGCCTGCAGCAGAGCTTCCTGTGCTGCGCCTTTGTCATCGCCCTGGGGGG
CGGCTGCTTCCTGCTGACTGCGCTGTACCTGGAGAGAGACGAGACCCGGGCCTGGCAGCCTGTCACAGGGACCCCAGACAGCAATGATGT
GGACAGCAACGACCTGGAGAGACAAGGCCTACTTTCGGGCGCTGGCGCCTCTACAGAGGAGCCCTGAGGTCCCTGCCTACACTCGTCCTG
CCTGCAAGCCTCCCGTTGGTCCCCACAGCAGCAGTGCCTCGGTTCCTCTTTGGCTGTCCTCGGGGACTCCGGCTGAGGCACATCTGCCAC
TTTTGAATTCCCGGCTGGAGAGCTGGCAGGACCCTGTGGCTGGGCTGGGAATGGAGCTGTCAGCACTCTGCGTGGGAGGCCTGGGCCTGT
GCCTGCATCCCGCTCAAGGCTGCCCCAGCCTGGGGTCTCCAGCCTGGCTGCTGCTGGGCCCTGAATAAAGAGAGGCCAGTACAAAGCCCA

>In-frame_ENST00000571732_ENST00000355530_TCGA-80-5611_YWHAE_chr17_1264385_-_SPNS3_chr17_4381866_length(amino acids)=265AA_start in transcript=209_stop in transcript=1006
MVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAA
NTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRCSWALGSCF

--------------------------------------------------------------
>In-frame_ENST00000571732_ENST00000333476_TCGA-80-5611_YWHAE_chr17_1264385_-_SPNS3_chr17_4381866_length(transcript)=1456nt_BP=721nt
ATTGAGGCGCCGCCATTTTTGCTGCCCGGACGCGGAGCGAGAGGCTGAGAGAGTCGGAGACACTATCCGCTTCCATCCGTCGCGCAGACC
CTGCCGGAGCCGCTGCCGCTATGGATGATCGAGAGGATCTGGTGTACCAGGCGAAGCTGGCCGAGCAGGCTGAGCGATACGACGTGCTCT
GGAACTGAACCCGCAGTATCTTCCAAGAAATGGTGGAGTCAATGAAGAAAGTAGCAGGGATGGATGTGGAGCTGACAGTTGAAGAAAGAA
ACCTCCTATCTGTTGCATATAAGAATGTGATTGGAGCTAGAAGAGCCTCCTGGAGAATAATCAGCAGCATTGAACAGAAAGAAGAAAACA
AGGGAGGAGAAGACAAGCTAAAAATGATTCGGGAATATCGGCAAATGGTTGAGACTGAGCTAAAGTTAATCTGTTGTGACATTCTGGATG
TACTGGACAAACACCTCATTCCAGCAGCTAACACTGGCGAGTCCAAGGTTTTCTATTATAAAATGAAAGGGGACTACCACAGGTATCTGG
CAGAATTTGCCACAGGAAACGACAGGAAGGAGGCTGCGGAGAACAGCCTAGTGGCTTATAAAGCTGCTAGTGATATTGCAATGACAGAAC
TTCCACCAACGCATCCTATTCGCTTAGGTCTTGCTCTCAATTTTTCCGTATTCTACTACGAAATTCTTAATTCCCCTGACCGTGCCTGCA
GGTGTTCCTGGGCCTTGGGGAGCTGCTTCTGTCCTGCAACTGGGCAGTGGTTGCCGACATCCTGCTGTCTGTGGTGGTGCCCAGATGCCG
GGGGACGGCAGAGGCACTTCAGATCACGGTGGGCCACATCCTGGGAGACGCTGGCAGCCCCTATCTCACAGGACTTATCTCTAGTGTCCT
GCGGGCCAGGCGCCCTGACTCCTATCTGCAGCGCTTCCGCAGCCTGCAGCAGAGCTTCCTGTGCTGCGCCTTTGTCATCGCCCTGGGGGG
CGGCTGCTTCCTGCTGACTGCGCTGTACCTGGAGAGAGACGAGACCCGGGCCTGGCAGCCTGTCACAGGGACCCCAGACAGCAATGATGT
GGACAGCAACGACCTGGAGAGACAAGGCCTACTTTCGGGCGCTGGCGCCTCTACAGAGGAGCCCTGAGGTCCCTGCCTACACTCGTCCTG
CCTGCAAGCCTCCCGTTGGTCCCCACAGCAGCAGTGCCTCGGTTCCTCTTTGGCTGTCCTCGGGGACTCCGGCTGAGGCACATCTGCCAC
TTTTGAATTCCCGGCTGGAGAGCTGGCAGGACCCTGTGGCTGGGCTGGGAATGGAGCTGTCAGCACTCTGCGTGGGAGGCCTGGGCCTGT
GCCTGCATCCCGCTCAAGGCTGCCCCAGCCTGGGGTCTCCAGCCTGGCTGCTGCTGGGCCCTGAATAAAGAGAGGCCAGTACAAAGCCCA

>In-frame_ENST00000571732_ENST00000333476_TCGA-80-5611_YWHAE_chr17_1264385_-_SPNS3_chr17_4381866_length(amino acids)=265AA_start in transcript=209_stop in transcript=1006
MVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAA
NTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRCSWALGSCF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for YWHAE-SPNS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for YWHAE-SPNS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for YWHAE-SPNS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneYWHAEC0036341Schizophrenia4PSYGENET
HgeneYWHAEC0005586Bipolar Disorder2PSYGENET
HgeneYWHAEC0206630Endometrial Stromal Sarcoma2ORPHANET
HgeneYWHAEC0027627Neoplasm Metastasis1CTD_human
HgeneYWHAEC0265219Miller Dieker syndrome1ORPHANET
HgeneYWHAEC0334488Clear cell sarcoma of kidney1ORPHANET
HgeneYWHAEC2750748Chromosome 17p13.3 Duplication Syndrome1ORPHANET
HgeneYWHAEC4707092Distal 17p13.3 microdeletion syndrome1ORPHANET