FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ZC3H4-PRL (FusionGDB2 ID:99890)

Fusion Gene Summary for ZC3H4-PRL

check button Fusion gene summary
Fusion gene informationFusion gene name: ZC3H4-PRL
Fusion gene ID: 99890
HgeneTgene
Gene symbol

ZC3H4

PRL

Gene ID

23211

5617

Gene namezinc finger CCCH-type containing 4prolactin
SynonymsC19orf7GHA1
Cytomap

19q13.32

6p22.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger CCCH domain-containing protein 4prolactindecidual prolactingrowth hormone A1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000253048, ENST00000594019, 
ENST00000306482, 
Fusion gene scores* DoF score10 X 11 X 7=7702 X 2 X 2=8
# samples 142
** MAII scorelog2(14/770*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: ZC3H4 [Title/Abstract] AND PRL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZC3H4(47588333)-PRL(22294687), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePRL

GO:0001937

negative regulation of endothelial cell proliferation

23619365

TgenePRL

GO:0046427

positive regulation of JAK-STAT cascade

12552091

TgenePRL

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

23619365


check buttonFusion gene breakpoints across ZC3H4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PRL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAV752015ZC3H4chr19

47588333

-PRLchr6

22294687

-


Top

Fusion Gene ORF analysis for ZC3H4-PRL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000253048ENST00000306482ZC3H4chr19

47588333

-PRLchr6

22294687

-
intron-3CDSENST00000594019ENST00000306482ZC3H4chr19

47588333

-PRLchr6

22294687

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for ZC3H4-PRL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ZC3H4-PRL


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for ZC3H4-PRL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ZC3H4-PRL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ZC3H4-PRL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ZC3H4-PRL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZC3H4C1535926Neurodevelopmental Disorders1CTD_human
TgenePRLC0242350Erectile dysfunction5CTD_human
TgenePRLC0020514Hyperprolactinemia4CTD_human
TgenePRLC0033375Prolactinoma4CTD_human
TgenePRLC0344452Microprolactinoma4CTD_human
TgenePRLC0344453Macroprolactinoma4CTD_human
TgenePRLC0032000Pituitary Adenoma3CTD_human
TgenePRLC0032019Pituitary Neoplasms3CTD_human
TgenePRLC0346300Pituitary carcinoma3CTD_human
TgenePRLC0001430Adenoma2CTD_human
TgenePRLC0016722Frigidity2CTD_human
TgenePRLC0018418Gynecomastia2CTD_human
TgenePRLC0020594Hypoactive Sexual Desire Disorder2CTD_human
TgenePRLC0020649Hypotension2CTD_human
TgenePRLC0024667Animal Mammary Neoplasms2CTD_human
TgenePRLC0029261Orgasmic Disorder2CTD_human
TgenePRLC0033953Psychosexual Disorders2CTD_human
TgenePRLC0036902Sexual Arousal Disorder2CTD_human
TgenePRLC0205646Adenoma, Basal Cell2CTD_human
TgenePRLC0205647Follicular adenoma2CTD_human
TgenePRLC0205648Adenoma, Microcystic2CTD_human
TgenePRLC0205649Adenoma, Monomorphic2CTD_human
TgenePRLC0205650Papillary adenoma2CTD_human
TgenePRLC0205651Adenoma, Trabecular2CTD_human
TgenePRLC0237873Physiological Sexual Disorders2CTD_human
TgenePRLC1257925Mammary Carcinoma, Animal2CTD_human
TgenePRLC1449720Adolescent Gynecomastia2CTD_human
TgenePRLC1449721Infant Gynecomastia2CTD_human
TgenePRLC0001418Adenocarcinoma1CTD_human
TgenePRLC0002453Amenorrhea1CTD_human
TgenePRLC0002871Anemia1CTD_human
TgenePRLC0004352Autistic Disorder1CTD_human
TgenePRLC0004782Basal Ganglia Diseases1CTD_human
TgenePRLC0005001Benign prostatic hypertrophy1CTD_human
TgenePRLC0007370Catalepsy1CTD_human
TgenePRLC0008909Claustrophobia1CTD_human
TgenePRLC0009171Cocaine Abuse1CTD_human
TgenePRLC0014175Endometriosis1CTD_human
TgenePRLC0015371Extrapyramidal Disorders1CTD_human
TgenePRLC0015951Fetal Resorption1CTD_human
TgenePRLC0015967Fever1CTD_human
TgenePRLC0018801Heart failure1CTD_human
TgenePRLC0018802Congestive heart failure1CTD_human
TgenePRLC0020619Hypogonadism1CTD_human
TgenePRLC0020635Hypopituitarism1CTD_human
TgenePRLC0021308Infarction1CTD_human
TgenePRLC0021361Female infertility1CTD_human
TgenePRLC0023212Left-Sided Heart Failure1CTD_human
TgenePRLC0023601Leydig Cell Tumor1CTD_human
TgenePRLC0024141Lupus Erythematosus, Systemic1CTD_human
TgenePRLC0024668Mammary Neoplasms, Experimental1CTD_human
TgenePRLC0032796Postpartum Amenorrhea1CTD_human
TgenePRLC0032963Pregnancy Complications, Cardiovascular1CTD_human
TgenePRLC0034040Puerperal Disorders1CTD_human
TgenePRLC0036341Schizophrenia1PSYGENET
TgenePRLC0038279Sterility, Postpartum1CTD_human
TgenePRLC0038587Substance Withdrawal Syndrome1CTD_human
TgenePRLC0086189Drug Withdrawal Symptoms1CTD_human
TgenePRLC0087169Withdrawal Symptoms1CTD_human
TgenePRLC0205641Adenocarcinoma, Basal Cell1CTD_human
TgenePRLC0205642Adenocarcinoma, Oxyphilic1CTD_human
TgenePRLC0205643Carcinoma, Cribriform1CTD_human
TgenePRLC0205644Carcinoma, Granular Cell1CTD_human
TgenePRLC0205645Adenocarcinoma, Tubular1CTD_human
TgenePRLC0233612Waxy flexibility1CTD_human
TgenePRLC0235527Heart Failure, Right-Sided1CTD_human
TgenePRLC0236736Cocaine-Related Disorders1CTD_human
TgenePRLC0242342Sheehan Syndrome1CTD_human
TgenePRLC0242380Libman-Sacks Disease1CTD_human
TgenePRLC0242422Parkinsonian Disorders1CTD_human
TgenePRLC0242423Ramsay Hunt Paralysis Syndrome1CTD_human
TgenePRLC0269102Endometrioma1CTD_human
TgenePRLC0271623Hypogonadotropic hypogonadism1CTD_human
TgenePRLC0341869Subfertility, Female1CTD_human
TgenePRLC0346302Growth Hormone-Secreting Pituitary Adenoma1CTD_human
TgenePRLC0349231Phobic anxiety disorder1CTD_human
TgenePRLC0428977Bradycardia1CTD_human
TgenePRLC0520477Prostatic Adenoma1CTD_human
TgenePRLC0525045Mood Disorders1PSYGENET
TgenePRLC0600427Cocaine Dependence1CTD_human
TgenePRLC0750951Lenticulostriate Disorders1CTD_human
TgenePRLC0752097Autosomal Dominant Juvenile Parkinson Disease1CTD_human
TgenePRLC0752098Autosomal Dominant Parkinsonism1CTD_human
TgenePRLC0752100Autosomal Recessive Parkinsonism1CTD_human
TgenePRLC0752101Parkinsonism, Experimental1CTD_human
TgenePRLC0752104Familial Juvenile Parkinsonism1CTD_human
TgenePRLC0752105Parkinsonism, Juvenile1CTD_human
TgenePRLC0917730Female sterility1CTD_human
TgenePRLC0948896Primary hypogonadism1CTD_human
TgenePRLC1704272Benign Prostatic Hyperplasia1CTD_human
TgenePRLC1739363Prostatic Hypertrophy1CTD_human
TgenePRLC1868675PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE1CTD_human
TgenePRLC1959583Myocardial Failure1CTD_human
TgenePRLC1961112Heart Decompensation1CTD_human
TgenePRLC2937421Prostatic Hyperplasia1CTD_human
TgenePRLC3489396Hypogonadism, Isolated Hypogonadotropic1CTD_human
TgenePRLC3489630Somatotrophinoma, Familial1CTD_human
TgenePRLC3665358Galactorrhea1CTD_human