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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ZC3H7B-L3MBTL2 (FusionGDB2 ID:99909)

Fusion Gene Summary for ZC3H7B-L3MBTL2

Fusion gene summary

Fusion gene information	Fusion gene name: ZC3H7B-L3MBTL2
	Fusion gene ID: 99909
		Hgene	Tgene
	Gene symbol	ZC3H7B	L3MBTL2
	Gene ID	23264	83746
	Gene name	zinc finger CCCH-type containing 7B	L3MBTL histone methyl-lysine binding protein 2
	Synonyms	ROXAN1\|RoXaN	H-l(3)mbt-l\|L3MBT
	Cytomap	22q13.2	22q13.2
	Type of gene	protein-coding	protein-coding
	Description	zinc finger CCCH domain-containing protein 7BRotavirus 'X' associated non-structural proteinrotavirus 'X'-associated non-structural proteinrotavirus X protein associated with NSP3ubiquitous tetratricopeptide containing protein RoXaN	lethal(3)malignant brain tumor-like protein 2H-l(3)mbt-like protein 2L(3)mbt-like protein 2L3MBTL2, polycomb repressive complex 1 subunitl(3)mbt-like 2
	Modification date	20200313	20200313
	UniProtAcc	.	Q969R5
	Ensembl transtripts involved in fusion gene	ENST00000352645, ENST00000351589,	ENST00000216237, ENST00000489136,
Fusion gene scores	* DoF score	15 X 12 X 9=1620	3 X 8 X 4=96
	# samples	18	7
	** MAII score	log2(18/1620*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/96*10)=-0.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZC3H7B [Title/Abstract] AND L3MBTL2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ZC3H7B(41697776)-L3MBTL2(41615423), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ZC3H7B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across L3MBTL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-EW-A6SB-01A	ZC3H7B	chr22	41723368	+	L3MBTL2	chr22	41605700	+
ChimerDB4	LIHC	TCGA-CC-A9FU-01A	ZC3H7B	chr22	41697776	+	L3MBTL2	chr22	41615423	+
ChimerDB4	LIHC	TCGA-CC-A9FU-01A	ZC3H7B	chr22	41697776	+	L3MBTL2	chr22	41615423	+
ChimerDB4	LIHC	TCGA-2Y-A9H3-01A	ZC3H7B	chr22	41723368	-	L3MBTL2	chr22	41620024	+
ChimerDB4	LIHC	TCGA-CC-A9FU-01A	ZC3H7B	chr22	41697776	-	L3MBTL2	chr22	41615423	+
ChimerDB4	BRCA	TCGA-EW-A6SB-01A	ZC3H7B	chr22	41723368	-	L3MBTL2	chr22	41605700	+

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Fusion Gene ORF analysis for ZC3H7B-L3MBTL2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000352645	ENST00000216237	ZC3H7B	chr22	41723368	+	L3MBTL2	chr22	41605700	+
5CDS-3UTR	ENST00000352645	ENST00000489136	ZC3H7B	chr22	41723368	+	L3MBTL2	chr22	41605700	+
In-frame	ENST00000351589	ENST00000216237	ZC3H7B	chr22	41723368	+	L3MBTL2	chr22	41605700	+
5CDS-3UTR	ENST00000351589	ENST00000489136	ZC3H7B	chr22	41723368	+	L3MBTL2	chr22	41605700	+
5UTR-3CDS	ENST00000352645	ENST00000216237	ZC3H7B	chr22	41697776	+	L3MBTL2	chr22	41615423	+
5UTR-intron	ENST00000352645	ENST00000489136	ZC3H7B	chr22	41697776	+	L3MBTL2	chr22	41615423	+
intron-3CDS	ENST00000351589	ENST00000216237	ZC3H7B	chr22	41697776	+	L3MBTL2	chr22	41615423	+
intron-intron	ENST00000351589	ENST00000489136	ZC3H7B	chr22	41697776	+	L3MBTL2	chr22	41615423	+
In-frame	ENST00000352645	ENST00000216237	ZC3H7B	chr22	41723368	-	L3MBTL2	chr22	41620024	+
5CDS-intron	ENST00000352645	ENST00000489136	ZC3H7B	chr22	41723368	-	L3MBTL2	chr22	41620024	+
In-frame	ENST00000351589	ENST00000216237	ZC3H7B	chr22	41723368	-	L3MBTL2	chr22	41620024	+
5CDS-intron	ENST00000351589	ENST00000489136	ZC3H7B	chr22	41723368	-	L3MBTL2	chr22	41620024	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000352645	ZC3H7B	chr22	41723368	+	ENST00000216237	L3MBTL2	chr22	41605700	+	3815	701	254	2794	846
ENST00000351589	ZC3H7B	chr22	41723368	+	ENST00000216237	L3MBTL2	chr22	41605700	+	3558	444	0	2537	845
ENST00000352645	ZC3H7B	chr22	41723368	-	ENST00000216237	L3MBTL2	chr22	41620024	+	2897	701	254	1876	540
ENST00000351589	ZC3H7B	chr22	41723368	-	ENST00000216237	L3MBTL2	chr22	41620024	+	2640	444	0	1619	539

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000352645	ENST00000216237	ZC3H7B	chr22	41723368	+	L3MBTL2	chr22	41605700	+	0.002754472	0.99724555
ENST00000351589	ENST00000216237	ZC3H7B	chr22	41723368	+	L3MBTL2	chr22	41605700	+	0.002823552	0.9971764
ENST00000352645	ENST00000216237	ZC3H7B	chr22	41723368	-	L3MBTL2	chr22	41620024	+	0.004507	0.99549294
ENST00000351589	ENST00000216237	ZC3H7B	chr22	41723368	-	L3MBTL2	chr22	41620024	+	0.004626217	0.9953738

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Fusion Genomic Features for ZC3H7B-L3MBTL2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ZC3H7B	chr22	41723368	+	L3MBTL2	chr22	41605699	+	3.40E-10	1
ZC3H7B	chr22	41697776	+	L3MBTL2	chr22	41615422	+	2.66E-09	1
ZC3H7B	chr22	41723368	+	L3MBTL2	chr22	41605699	+	3.40E-10	1
ZC3H7B	chr22	41697776	+	L3MBTL2	chr22	41615422	+	2.66E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZC3H7B-L3MBTL2

Go to
FGviewer for the breakpoints of chr22:41723368-chr22:41605700
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	L3MBTL2 Q969R5
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. {ECO:0000269\|PubMed:19233876}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZC3H7B

chr22:41723368

chr22:41605700

ENST00000351589

1_27

148.0

978.0

Repeat

TPR 1

Hgene

ZC3H7B

chr22:41723368

chr22:41605700

ENST00000351589

36_69

148.0

978.0

Repeat

TPR 2

Hgene

ZC3H7B

chr22:41723368

chr22:41605700

ENST00000351589

82_115

148.0

978.0

Repeat

TPR 3

Hgene

ZC3H7B

chr22:41723368

chr22:41605700

ENST00000352645

1_27

148.0

978.0

Repeat

TPR 1

Hgene

ZC3H7B

chr22:41723368

chr22:41605700

ENST00000352645

36_69

148.0

978.0

Repeat

TPR 2

Hgene

ZC3H7B

chr22:41723368

chr22:41605700

ENST00000352645

82_115

148.0

978.0

Repeat

TPR 3

Hgene

ZC3H7B

chr22:41723368

chr22:41620024

ENST00000351589

1_27

148.0

978.0

Repeat

TPR 1

Hgene

ZC3H7B

chr22:41723368

chr22:41620024

ENST00000351589

36_69

148.0

978.0

Repeat

TPR 2

Hgene

ZC3H7B

chr22:41723368

chr22:41620024

ENST00000351589

82_115

148.0

978.0

Repeat

TPR 3

Hgene

ZC3H7B

chr22:41723368

chr22:41620024

ENST00000352645

1_27

148.0

978.0

Repeat

TPR 1

Hgene

ZC3H7B

chr22:41723368

chr22:41620024

ENST00000352645

36_69

148.0

978.0

Repeat

TPR 2

Hgene

ZC3H7B

chr22:41723368

chr22:41620024

ENST00000352645

82_115

148.0

978.0

Repeat

TPR 3

Tgene

L3MBTL2

chr22:41723368

chr22:41605700

ENST00000216237

17_20

8.0

706.0

Compositional bias

Note=Poly-Glu

Tgene

L3MBTL2

chr22:41723368

chr22:41605700

ENST00000216237

620_624

8.0

706.0

Compositional bias

Note=Poly-Lys

Tgene

L3MBTL2

chr22:41723368

chr22:41620024

ENST00000216237

620_624

314.0

706.0

Compositional bias

Note=Poly-Lys

Tgene

L3MBTL2

chr22:41723368

chr22:41605700

ENST00000216237

179_283

8.0

706.0

Repeat

Note=MBT 1

Tgene

L3MBTL2

chr22:41723368

chr22:41605700

ENST00000216237

291_391

8.0

706.0

Repeat

Note=MBT 2

Tgene

L3MBTL2

chr22:41723368

chr22:41605700

ENST00000216237

397_500

8.0

706.0

Repeat

Note=MBT 3

Tgene

L3MBTL2

chr22:41723368

chr22:41605700

ENST00000216237

508_604

8.0

706.0

Repeat

Note=MBT 4

Tgene

L3MBTL2

chr22:41723368

chr22:41620024

ENST00000216237

397_500

314.0

706.0

Repeat

Note=MBT 3

Tgene

L3MBTL2

chr22:41723368

chr22:41620024

ENST00000216237

508_604

314.0

706.0

Repeat

Note=MBT 4

Tgene

L3MBTL2

chr22:41723368

chr22:41605700

ENST00000216237

81_116

8.0

706.0

Zinc finger

FCS-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZC3H7B

chr22:41723368

chr22:41605700

ENST00000351589

484_508

148.0

978.0

Zinc finger

C3H1-type 1

Hgene

ZC3H7B

chr22:41723368

chr22:41605700

ENST00000351589

616_638

148.0

978.0

Zinc finger

C3H1-type 2

Hgene

ZC3H7B

chr22:41723368

chr22:41605700

ENST00000351589

754_782

148.0

978.0

Zinc finger

C3H1-type 3

Hgene

ZC3H7B

chr22:41723368

chr22:41605700

ENST00000351589

842_866

148.0

978.0

Zinc finger

C2H2-type

Hgene

ZC3H7B

chr22:41723368

chr22:41605700

ENST00000351589

886_914

148.0

978.0

Zinc finger

C3H1-type 4

Hgene

ZC3H7B

chr22:41723368

chr22:41605700

ENST00000352645

484_508

148.0

978.0

Zinc finger

C3H1-type 1

Hgene

ZC3H7B

chr22:41723368

chr22:41605700

ENST00000352645

616_638

148.0

978.0

Zinc finger

C3H1-type 2

Hgene

ZC3H7B

chr22:41723368

chr22:41605700

ENST00000352645

754_782

148.0

978.0

Zinc finger

C3H1-type 3

Hgene

ZC3H7B

chr22:41723368

chr22:41605700

ENST00000352645

842_866

148.0

978.0

Zinc finger

C2H2-type

Hgene

ZC3H7B

chr22:41723368

chr22:41605700

ENST00000352645

886_914

148.0

978.0

Zinc finger

C3H1-type 4

Hgene

ZC3H7B

chr22:41723368

chr22:41620024

ENST00000351589

484_508

148.0

978.0

Zinc finger

C3H1-type 1

Hgene

ZC3H7B

chr22:41723368

chr22:41620024

ENST00000351589

616_638

148.0

978.0

Zinc finger

C3H1-type 2

Hgene

ZC3H7B

chr22:41723368

chr22:41620024

ENST00000351589

754_782

148.0

978.0

Zinc finger

C3H1-type 3

Hgene

ZC3H7B

chr22:41723368

chr22:41620024

ENST00000351589

842_866

148.0

978.0

Zinc finger

C2H2-type

Hgene

ZC3H7B

chr22:41723368

chr22:41620024

ENST00000351589

886_914

148.0

978.0

Zinc finger

C3H1-type 4

Hgene

ZC3H7B

chr22:41723368

chr22:41620024

ENST00000352645

484_508

148.0

978.0

Zinc finger

C3H1-type 1

Hgene

ZC3H7B

chr22:41723368

chr22:41620024

ENST00000352645

616_638

148.0

978.0

Zinc finger

C3H1-type 2

Hgene

ZC3H7B

chr22:41723368

chr22:41620024

ENST00000352645

754_782

148.0

978.0

Zinc finger

C3H1-type 3

Hgene

ZC3H7B

chr22:41723368

chr22:41620024

ENST00000352645

842_866

148.0

978.0

Zinc finger

C2H2-type

Hgene

ZC3H7B

chr22:41723368

chr22:41620024

ENST00000352645

886_914

148.0

978.0

Zinc finger

C3H1-type 4

Tgene

L3MBTL2

chr22:41723368

chr22:41620024

ENST00000216237

17_20

314.0

706.0

Compositional bias

Note=Poly-Glu

Tgene

L3MBTL2

chr22:41723368

chr22:41620024

ENST00000216237

179_283

314.0

706.0

Repeat

Note=MBT 1

Tgene

L3MBTL2

chr22:41723368

chr22:41620024

ENST00000216237

291_391

314.0

706.0

Repeat

Note=MBT 2

Tgene

L3MBTL2

chr22:41723368

chr22:41620024

ENST00000216237

81_116

314.0

706.0

Zinc finger

FCS-type

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Fusion Gene Sequence for ZC3H7B-L3MBTL2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000352645_ENST00000216237_TCGA-EW-A6SB-01A_ZC3H7B_chr22_41723368_+_L3MBTL2_chr22_41605700_length(transcript)=3815nt_BP=701nt
AGGGAGACAGTGCCTCCAGCGGGTGCTGCCGCGAGCGGCCAGCCGAGGGGCTGGAAATGAAAGTAAAGCGCTCCAGAGCCACATGGACGG
AGCTGCCGGGGCGGCGGCGCCGGGAGCAGGATGCGGCCGCCCGTAATTAAATAGCATTTACTCTTATTATTACTAATAATAATAACGTAA
TCATACCTCTAGTCATAGCATACCATTTATCGGGCTCGGCGCAGGCCCGCGGGGAGCGCAGCCCGGCGGAGAGACTGATGGAGAGGCAGA
AACGGAAGGCGGACATCGAGAAAGGGCTGCAGTTCATTCAGTCGACACTACCCCTAAAGCAAGAAGAATATGAGGCCTTTCTGCTCAAGC
TGGTGCAGAATCTGTTTGCTGAGGGCAATGATCTGTTCCGGGAGAAGGACTATAAGCAGGCTCTGGTGCAGTACATGGAAGGGCTGAACG
TGGCCGACTACGCTGCCTCTGACCAGGTGGCCCTGCCCCGGGAGCTGCTGTGCAAGCTGCATGTCAATAGGGCCGCCTGCTACTTCACCA
TGGGCCTGTATGAGAAGGCGCTGGAGGACAGCGAGAAGGCGCTGGGCCTGGACAGTGAGAGTATCCGGGCGTTGTTCCGCAAGGCACGCG
CTCTCAATGAACTGGGACGCCACAAGGAGGCCTACGAGTGCAGCAGCCGGTGTTCCCTCGCCCTGCCCCACGAGACCCCATCTTCAGAAC
CAATGGAGGAAGAGGAAGATGACGACTTGGAGCTGTTTGGTGGCTATGATAGTTTCCGGAGTTATAACAGCAGTGTGGGCAGTGAGAGCA
GCTCCTATCTGGAGGAGTCAAGTGAAGCAGAAAATGAGGATCGGGAAGCAGGGGAACTGCCGACCTCCCCGCTGCATTTGCTCAGCCCTG
GGACTCCTCGCTCCTTGGATGGCAGTGGTTCTGAGCCAGCTGTCTGTGAGATGTGTGGTATCGTGGGTACAAGGGAAGCCTTCTTCTCCA
AGACCAAGAGGTTCTGCAGCGTCTCCTGCTCCAGGAGCTACTCCTCCAACTCCAAGAAAGCCAGTATCTTGGCTAGGTTACAGGGAAAAC
CACCGACCAAAAAAGCCAAAGTCCTGCACAAGGCTGCCTGGTCTGCCAAAATTGGAGCCTTCCTCCACTCTCAAGGGACAGGACAGCTGG
CAGATGGGACACCAACAGGACAAGACGCTCTGGTCTTGGGCTTCGACTGGGGGAAGTTCCTGAAGGATCACAGTTACAAGGCTGCTCCCG
TCAGCTGTTTCAAGCACGTCCCACTCTATGACCAGTGGGAGGATGTGATGAAAGGGATGAAGGTGGAGGTGCTCAACAGTGATGCTGTGC
TCCCCAGCCGGGTGTACTGGATCGCCTCTGTCATCCAGACAGCAGGGTATCGGGTGCTGCTTCGGTATGAAGGCTTTGAAAATGACGCCA
GCCATGACTTCTGGTGCAACCTGGGAACAGTGGATGTCCACCCCATTGGCTGGTGTGCCATCAACAGCAAGATCCTAGTGCCCCCACGGA
CCATCCATGCCAAGTTCACCGACTGGAAGGGCTACCTCATGAAACGGCTGGTGGGCTCCAGGACGCTTCCCGTGGATTTCCACATCAAGA
TGGTGGAGAGCATGAAGTACCCCTTTAGGCAGGGCATGCGGCTGGAAGTGGTGGACAAGTCCCAGGTGTCACGCACTCGCATGGCTGTGG
TGGACACAGTAATCGGGGGTCGCCTACGGCTCCTCTACGAGGATGGTGACAGTGACGACGACTTCTGGTGCCACATGTGGAGCCCCCTGA
TCCACCCAGTGGGTTGGTCACGACGTGTGGGCCACGGCATCAAGATGTCAGAGAGGCGAAGTGACATGGCCCATCACCCCACCTTCCGGA
AGATCTACTGTGATGCCGTTCCTTACCTCTTCAAGAAGGTACGAGCAGTCTACACAGAAGGCGGTTGGTTTGAGGAAGGGATGAAGCTGG
AGGCCATTGACCCCCTGAATCTGGGCAACATCTGCGTGGCAACTGTCTGTAAGGTTCTCCTGGATGGATACCTGATGATCTGTGTGGACG
GGGGGCCCTCCACAGATGGCTTGGACTGGTTCTGCTACCATGCCTCTTCCCACGCCATCTTCCCGGCCACCTTCTGTCAGAAGAATGACA
TTGAGCTCACACCGCCAAAAGGTTATGAGGCACAGACTTTCAACTGGGAGAACTACTTGGAGAAGACCAAGTCGAAAGCCGCTCCATCGA
GACTCTTTAACATGGATTGCCCAAACCATGGCTTCAAGGTGGGCATGAAGCTGGAGGCCGTGGACCTGATGGAGCCCCGGCTCATCTGTG
TGGCCACGGTGAAACGAGTGGTGCATCGGCTCCTCAGCATCCACTTTGACGGCTGGGACAGCGAGTACGACCAGTGGGTGGACTGCGAGT
CCCCAGACATCTACCCCGTCGGCTGGTGTGAGCTCACCGGCTACCAGCTCCAGCCTCCTGTGGCCGCAGAACCGGCCACACCGCTGAAGG
CCAAAGAGGCCACAAAGAAGAAAAAGAAACAGTTTGGGAAGAAAAGGAAAAGAATCCCGCCCACTAAGACGCGACCCCTCAGACAGGGGT
CCAAGAAGCCCCTGCTGGAGGACGACCCTCAGGGTGCCAGGAAGATCTCGTCGGAGCCTGTTCCTGGCGAGATCATTGCTGTGCGTGTGA
AGGAAGAGCATCTAGACGTGGCCTCGCCCGACAAGGCTTCAAGTCCAGAGCTGCCTGTCTCCGTCGAGAACATCAAGCAGGAAACAGACG
ACTGAGCCTTCCTGCCTCCAGCCTGGCTTCTAGCTGGAAGCCAGCCCAGCGTTTCTCTACCACCACCACCATGCCTCCACCTGACTTTGG
CTTGGAGACTGATCCTCTCTGTGTAAATTCTGCCCGGTGCTGTGAAGGCTGGACGGTGGAGGACCTGCTGGGGTCTCCTGGGACCCGCCT
GTTGCTTCTGCCCTCCCCTGTGGAAAGGTCTATATGACGGGCCGCCTGAGGCCCCAGAACTCGTCTGTGAACCACCTTTTCCAGCCAGAG
TTCCCAAAGCTGGAACGCTAGCTGCCTGCTCTTCCTTAAGATGGCCTCCCCCCGACCCGCCACGGCCCTCAGTTGCCAGGGATGGGGCCA
CCACTGTCACACTGTGGAATACAAGACAGTGAACTCTGTCTGCCTGAACGAGCCATGTAAATTAAGTTCTAGAGCAGCTCTCTGAGCAGG
ATAAGGTCCCCTGACAGTGAGTTGTGTGGTGGGGGCAGCCTCTGCCTCAAAAATTCACCAAGCAGAATGCCTCTCAGCCTCATGTGTTGG
TCCTCTGCTCCTCCTAGCTCCCCAGGGATGTTGGGGACCCAGCTTGTCTCGGCAGCTAAGAAGCAGTGACCAGGATGTGGATTTTGGCGA
CCTGTGTGGTGGCCTTGAGCTGCTTTCTGTGTTTGTGAGGACTGACTCCCATTTCCTAAAGGAAATGCCCCCGGGGAGGACATTGGGAGG
AAGATGGCCTGAGTGTGCACTTTGGCTCTGCTACCTGCTCCTGAAGCCCCGCTAAAAATAATTCATCCAAGATTCCTTTGTAGTTAAAGG
GTCCAGTTCTGACTGGAGCCTCTAGAGAGCTGGGCTTGTATGTTCTTTTGGCCTTTTGTTCCTACCTAAATGAAGAAACCATGCCTGGAG
GGGCCGTGAACACAGAACCCTCAAGACAAGGATGACAGAGCTGGAGGACACATCTAGCTGCCATTGCAACCTCACTGGGCTCCCCAGACT

>In-frame_ENST00000352645_ENST00000216237_TCGA-EW-A6SB-01A_ZC3H7B_chr22_41723368_+_L3MBTL2_chr22_41605700_length(amino acids)=846AA_start in transcript=254_stop in transcript=2794
MMERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRA
ACYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHETPSSEPMEEEEDDDLELFGGYDSFRSYNSS
VGSESSSYLEESSEAENEDREAGELPTSPLHLLSPGTPRSLDGSGSEPAVCEMCGIVGTREAFFSKTKRFCSVSCSRSYSSNSKKASILA
RLQGKPPTKKAKVLHKAAWSAKIGAFLHSQGTGQLADGTPTGQDALVLGFDWGKFLKDHSYKAAPVSCFKHVPLYDQWEDVMKGMKVEVL
NSDAVLPSRVYWIASVIQTAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTDWKGYLMKRLVGSRTLPV
DFHIKMVESMKYPFRQGMRLEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSERRSDMAH
HPTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLEAIDPLNLGNICVATVCKVLLDGYLMICVDGGPSTDGLDWFCYHASSHAIFPATF
CQKNDIELTPPKGYEAQTFNWENYLEKTKSKAAPSRLFNMDCPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQ
WVDCESPDIYPVGWCELTGYQLQPPVAAEPATPLKAKEATKKKKKQFGKKRKRIPPTKTRPLRQGSKKPLLEDDPQGARKISSEPVPGEI

--------------------------------------------------------------
>In-frame_ENST00000351589_ENST00000216237_TCGA-EW-A6SB-01A_ZC3H7B_chr22_41723368_+_L3MBTL2_chr22_41605700_length(transcript)=3558nt_BP=444nt
ATGGAGAGGCAGAAACGGAAGGCGGACATCGAGAAAGGGCTGCAGTTCATTCAGTCGACACTACCCCTAAAGCAAGAAGAATATGAGGCC
TTTCTGCTCAAGCTGGTGCAGAATCTGTTTGCTGAGGGCAATGATCTGTTCCGGGAGAAGGACTATAAGCAGGCTCTGGTGCAGTACATG
GAAGGGCTGAACGTGGCCGACTACGCTGCCTCTGACCAGGTGGCCCTGCCCCGGGAGCTGCTGTGCAAGCTGCATGTCAATAGGGCCGCC
TGCTACTTCACCATGGGCCTGTATGAGAAGGCGCTGGAGGACAGCGAGAAGGCGCTGGGCCTGGACAGTGAGAGTATCCGGGCGTTGTTC
CGCAAGGCACGCGCTCTCAATGAACTGGGACGCCACAAGGAGGCCTACGAGTGCAGCAGCCGGTGTTCCCTCGCCCTGCCCCACGAGACC
CCATCTTCAGAACCAATGGAGGAAGAGGAAGATGACGACTTGGAGCTGTTTGGTGGCTATGATAGTTTCCGGAGTTATAACAGCAGTGTG
GGCAGTGAGAGCAGCTCCTATCTGGAGGAGTCAAGTGAAGCAGAAAATGAGGATCGGGAAGCAGGGGAACTGCCGACCTCCCCGCTGCAT
TTGCTCAGCCCTGGGACTCCTCGCTCCTTGGATGGCAGTGGTTCTGAGCCAGCTGTCTGTGAGATGTGTGGTATCGTGGGTACAAGGGAA
GCCTTCTTCTCCAAGACCAAGAGGTTCTGCAGCGTCTCCTGCTCCAGGAGCTACTCCTCCAACTCCAAGAAAGCCAGTATCTTGGCTAGG
TTACAGGGAAAACCACCGACCAAAAAAGCCAAAGTCCTGCACAAGGCTGCCTGGTCTGCCAAAATTGGAGCCTTCCTCCACTCTCAAGGG
ACAGGACAGCTGGCAGATGGGACACCAACAGGACAAGACGCTCTGGTCTTGGGCTTCGACTGGGGGAAGTTCCTGAAGGATCACAGTTAC
AAGGCTGCTCCCGTCAGCTGTTTCAAGCACGTCCCACTCTATGACCAGTGGGAGGATGTGATGAAAGGGATGAAGGTGGAGGTGCTCAAC
AGTGATGCTGTGCTCCCCAGCCGGGTGTACTGGATCGCCTCTGTCATCCAGACAGCAGGGTATCGGGTGCTGCTTCGGTATGAAGGCTTT
GAAAATGACGCCAGCCATGACTTCTGGTGCAACCTGGGAACAGTGGATGTCCACCCCATTGGCTGGTGTGCCATCAACAGCAAGATCCTA
GTGCCCCCACGGACCATCCATGCCAAGTTCACCGACTGGAAGGGCTACCTCATGAAACGGCTGGTGGGCTCCAGGACGCTTCCCGTGGAT
TTCCACATCAAGATGGTGGAGAGCATGAAGTACCCCTTTAGGCAGGGCATGCGGCTGGAAGTGGTGGACAAGTCCCAGGTGTCACGCACT
CGCATGGCTGTGGTGGACACAGTAATCGGGGGTCGCCTACGGCTCCTCTACGAGGATGGTGACAGTGACGACGACTTCTGGTGCCACATG
TGGAGCCCCCTGATCCACCCAGTGGGTTGGTCACGACGTGTGGGCCACGGCATCAAGATGTCAGAGAGGCGAAGTGACATGGCCCATCAC
CCCACCTTCCGGAAGATCTACTGTGATGCCGTTCCTTACCTCTTCAAGAAGGTACGAGCAGTCTACACAGAAGGCGGTTGGTTTGAGGAA
GGGATGAAGCTGGAGGCCATTGACCCCCTGAATCTGGGCAACATCTGCGTGGCAACTGTCTGTAAGGTTCTCCTGGATGGATACCTGATG
ATCTGTGTGGACGGGGGGCCCTCCACAGATGGCTTGGACTGGTTCTGCTACCATGCCTCTTCCCACGCCATCTTCCCGGCCACCTTCTGT
CAGAAGAATGACATTGAGCTCACACCGCCAAAAGGTTATGAGGCACAGACTTTCAACTGGGAGAACTACTTGGAGAAGACCAAGTCGAAA
GCCGCTCCATCGAGACTCTTTAACATGGATTGCCCAAACCATGGCTTCAAGGTGGGCATGAAGCTGGAGGCCGTGGACCTGATGGAGCCC
CGGCTCATCTGTGTGGCCACGGTGAAACGAGTGGTGCATCGGCTCCTCAGCATCCACTTTGACGGCTGGGACAGCGAGTACGACCAGTGG
GTGGACTGCGAGTCCCCAGACATCTACCCCGTCGGCTGGTGTGAGCTCACCGGCTACCAGCTCCAGCCTCCTGTGGCCGCAGAACCGGCC
ACACCGCTGAAGGCCAAAGAGGCCACAAAGAAGAAAAAGAAACAGTTTGGGAAGAAAAGGAAAAGAATCCCGCCCACTAAGACGCGACCC
CTCAGACAGGGGTCCAAGAAGCCCCTGCTGGAGGACGACCCTCAGGGTGCCAGGAAGATCTCGTCGGAGCCTGTTCCTGGCGAGATCATT
GCTGTGCGTGTGAAGGAAGAGCATCTAGACGTGGCCTCGCCCGACAAGGCTTCAAGTCCAGAGCTGCCTGTCTCCGTCGAGAACATCAAG
CAGGAAACAGACGACTGAGCCTTCCTGCCTCCAGCCTGGCTTCTAGCTGGAAGCCAGCCCAGCGTTTCTCTACCACCACCACCATGCCTC
CACCTGACTTTGGCTTGGAGACTGATCCTCTCTGTGTAAATTCTGCCCGGTGCTGTGAAGGCTGGACGGTGGAGGACCTGCTGGGGTCTC
CTGGGACCCGCCTGTTGCTTCTGCCCTCCCCTGTGGAAAGGTCTATATGACGGGCCGCCTGAGGCCCCAGAACTCGTCTGTGAACCACCT
TTTCCAGCCAGAGTTCCCAAAGCTGGAACGCTAGCTGCCTGCTCTTCCTTAAGATGGCCTCCCCCCGACCCGCCACGGCCCTCAGTTGCC
AGGGATGGGGCCACCACTGTCACACTGTGGAATACAAGACAGTGAACTCTGTCTGCCTGAACGAGCCATGTAAATTAAGTTCTAGAGCAG
CTCTCTGAGCAGGATAAGGTCCCCTGACAGTGAGTTGTGTGGTGGGGGCAGCCTCTGCCTCAAAAATTCACCAAGCAGAATGCCTCTCAG
CCTCATGTGTTGGTCCTCTGCTCCTCCTAGCTCCCCAGGGATGTTGGGGACCCAGCTTGTCTCGGCAGCTAAGAAGCAGTGACCAGGATG
TGGATTTTGGCGACCTGTGTGGTGGCCTTGAGCTGCTTTCTGTGTTTGTGAGGACTGACTCCCATTTCCTAAAGGAAATGCCCCCGGGGA
GGACATTGGGAGGAAGATGGCCTGAGTGTGCACTTTGGCTCTGCTACCTGCTCCTGAAGCCCCGCTAAAAATAATTCATCCAAGATTCCT
TTGTAGTTAAAGGGTCCAGTTCTGACTGGAGCCTCTAGAGAGCTGGGCTTGTATGTTCTTTTGGCCTTTTGTTCCTACCTAAATGAAGAA
ACCATGCCTGGAGGGGCCGTGAACACAGAACCCTCAAGACAAGGATGACAGAGCTGGAGGACACATCTAGCTGCCATTGCAACCTCACTG

>In-frame_ENST00000351589_ENST00000216237_TCGA-EW-A6SB-01A_ZC3H7B_chr22_41723368_+_L3MBTL2_chr22_41605700_length(amino acids)=845AA_start in transcript=0_stop in transcript=2537
MERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRAA
CYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHETPSSEPMEEEEDDDLELFGGYDSFRSYNSSV
GSESSSYLEESSEAENEDREAGELPTSPLHLLSPGTPRSLDGSGSEPAVCEMCGIVGTREAFFSKTKRFCSVSCSRSYSSNSKKASILAR
LQGKPPTKKAKVLHKAAWSAKIGAFLHSQGTGQLADGTPTGQDALVLGFDWGKFLKDHSYKAAPVSCFKHVPLYDQWEDVMKGMKVEVLN
SDAVLPSRVYWIASVIQTAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTDWKGYLMKRLVGSRTLPVD
FHIKMVESMKYPFRQGMRLEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSERRSDMAHH
PTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLEAIDPLNLGNICVATVCKVLLDGYLMICVDGGPSTDGLDWFCYHASSHAIFPATFC
QKNDIELTPPKGYEAQTFNWENYLEKTKSKAAPSRLFNMDCPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQW
VDCESPDIYPVGWCELTGYQLQPPVAAEPATPLKAKEATKKKKKQFGKKRKRIPPTKTRPLRQGSKKPLLEDDPQGARKISSEPVPGEII

--------------------------------------------------------------
>In-frame_ENST00000352645_ENST00000216237_TCGA-2Y-A9H3-01A_ZC3H7B_chr22_41723368_-_L3MBTL2_chr22_41620024_length(transcript)=2897nt_BP=701nt
AGGGAGACAGTGCCTCCAGCGGGTGCTGCCGCGAGCGGCCAGCCGAGGGGCTGGAAATGAAAGTAAAGCGCTCCAGAGCCACATGGACGG
AGCTGCCGGGGCGGCGGCGCCGGGAGCAGGATGCGGCCGCCCGTAATTAAATAGCATTTACTCTTATTATTACTAATAATAATAACGTAA
TCATACCTCTAGTCATAGCATACCATTTATCGGGCTCGGCGCAGGCCCGCGGGGAGCGCAGCCCGGCGGAGAGACTGATGGAGAGGCAGA
AACGGAAGGCGGACATCGAGAAAGGGCTGCAGTTCATTCAGTCGACACTACCCCTAAAGCAAGAAGAATATGAGGCCTTTCTGCTCAAGC
TGGTGCAGAATCTGTTTGCTGAGGGCAATGATCTGTTCCGGGAGAAGGACTATAAGCAGGCTCTGGTGCAGTACATGGAAGGGCTGAACG
TGGCCGACTACGCTGCCTCTGACCAGGTGGCCCTGCCCCGGGAGCTGCTGTGCAAGCTGCATGTCAATAGGGCCGCCTGCTACTTCACCA
TGGGCCTGTATGAGAAGGCGCTGGAGGACAGCGAGAAGGCGCTGGGCCTGGACAGTGAGAGTATCCGGGCGTTGTTCCGCAAGGCACGCG
CTCTCAATGAACTGGGACGCCACAAGGAGGCCTACGAGTGCAGCAGCCGGTGTTCCCTCGCCCTGCCCCACATGGTGGAGAGCATGAAGT
ACCCCTTTAGGCAGGGCATGCGGCTGGAAGTGGTGGACAAGTCCCAGGTGTCACGCACTCGCATGGCTGTGGTGGACACAGTAATCGGGG
GTCGCCTACGGCTCCTCTACGAGGATGGTGACAGTGACGACGACTTCTGGTGCCACATGTGGAGCCCCCTGATCCACCCAGTGGGTTGGT
CACGACGTGTGGGCCACGGCATCAAGATGTCAGAGAGGCGAAGTGACATGGCCCATCACCCCACCTTCCGGAAGATCTACTGTGATGCCG
TTCCTTACCTCTTCAAGAAGGTACGAGCAGTCTACACAGAAGGCGGTTGGTTTGAGGAAGGGATGAAGCTGGAGGCCATTGACCCCCTGA
ATCTGGGCAACATCTGCGTGGCAACTGTCTGTAAGGTTCTCCTGGATGGATACCTGATGATCTGTGTGGACGGGGGGCCCTCCACAGATG
GCTTGGACTGGTTCTGCTACCATGCCTCTTCCCACGCCATCTTCCCGGCCACCTTCTGTCAGAAGAATGACATTGAGCTCACACCGCCAA
AAGGTTATGAGGCACAGACTTTCAACTGGGAGAACTACTTGGAGAAGACCAAGTCGAAAGCCGCTCCATCGAGACTCTTTAACATGGATT
GCCCAAACCATGGCTTCAAGGTGGGCATGAAGCTGGAGGCCGTGGACCTGATGGAGCCCCGGCTCATCTGTGTGGCCACGGTGAAACGAG
TGGTGCATCGGCTCCTCAGCATCCACTTTGACGGCTGGGACAGCGAGTACGACCAGTGGGTGGACTGCGAGTCCCCAGACATCTACCCCG
TCGGCTGGTGTGAGCTCACCGGCTACCAGCTCCAGCCTCCTGTGGCCGCAGAACCGGCCACACCGCTGAAGGCCAAAGAGGCCACAAAGA
AGAAAAAGAAACAGTTTGGGAAGAAAAGGAAAAGAATCCCGCCCACTAAGACGCGACCCCTCAGACAGGGGTCCAAGAAGCCCCTGCTGG
AGGACGACCCTCAGGGTGCCAGGAAGATCTCGTCGGAGCCTGTTCCTGGCGAGATCATTGCTGTGCGTGTGAAGGAAGAGCATCTAGACG
TGGCCTCGCCCGACAAGGCTTCAAGTCCAGAGCTGCCTGTCTCCGTCGAGAACATCAAGCAGGAAACAGACGACTGAGCCTTCCTGCCTC
CAGCCTGGCTTCTAGCTGGAAGCCAGCCCAGCGTTTCTCTACCACCACCACCATGCCTCCACCTGACTTTGGCTTGGAGACTGATCCTCT
CTGTGTAAATTCTGCCCGGTGCTGTGAAGGCTGGACGGTGGAGGACCTGCTGGGGTCTCCTGGGACCCGCCTGTTGCTTCTGCCCTCCCC
TGTGGAAAGGTCTATATGACGGGCCGCCTGAGGCCCCAGAACTCGTCTGTGAACCACCTTTTCCAGCCAGAGTTCCCAAAGCTGGAACGC
TAGCTGCCTGCTCTTCCTTAAGATGGCCTCCCCCCGACCCGCCACGGCCCTCAGTTGCCAGGGATGGGGCCACCACTGTCACACTGTGGA
ATACAAGACAGTGAACTCTGTCTGCCTGAACGAGCCATGTAAATTAAGTTCTAGAGCAGCTCTCTGAGCAGGATAAGGTCCCCTGACAGT
GAGTTGTGTGGTGGGGGCAGCCTCTGCCTCAAAAATTCACCAAGCAGAATGCCTCTCAGCCTCATGTGTTGGTCCTCTGCTCCTCCTAGC
TCCCCAGGGATGTTGGGGACCCAGCTTGTCTCGGCAGCTAAGAAGCAGTGACCAGGATGTGGATTTTGGCGACCTGTGTGGTGGCCTTGA
GCTGCTTTCTGTGTTTGTGAGGACTGACTCCCATTTCCTAAAGGAAATGCCCCCGGGGAGGACATTGGGAGGAAGATGGCCTGAGTGTGC
ACTTTGGCTCTGCTACCTGCTCCTGAAGCCCCGCTAAAAATAATTCATCCAAGATTCCTTTGTAGTTAAAGGGTCCAGTTCTGACTGGAG
CCTCTAGAGAGCTGGGCTTGTATGTTCTTTTGGCCTTTTGTTCCTACCTAAATGAAGAAACCATGCCTGGAGGGGCCGTGAACACAGAAC
CCTCAAGACAAGGATGACAGAGCTGGAGGACACATCTAGCTGCCATTGCAACCTCACTGGGCTCCCCAGACTCTGTGTGTGAGAAATTAA

>In-frame_ENST00000352645_ENST00000216237_TCGA-2Y-A9H3-01A_ZC3H7B_chr22_41723368_-_L3MBTL2_chr22_41620024_length(amino acids)=540AA_start in transcript=254_stop in transcript=1876
MMERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRA
ACYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHMVESMKYPFRQGMRLEVVDKSQVSRTRMAVV
DTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSERRSDMAHHPTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLE
AIDPLNLGNICVATVCKVLLDGYLMICVDGGPSTDGLDWFCYHASSHAIFPATFCQKNDIELTPPKGYEAQTFNWENYLEKTKSKAAPSR
LFNMDCPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQPPVAAEPATPLKA
KEATKKKKKQFGKKRKRIPPTKTRPLRQGSKKPLLEDDPQGARKISSEPVPGEIIAVRVKEEHLDVASPDKASSPELPVSVENIKQETDD

--------------------------------------------------------------
>In-frame_ENST00000351589_ENST00000216237_TCGA-2Y-A9H3-01A_ZC3H7B_chr22_41723368_-_L3MBTL2_chr22_41620024_length(transcript)=2640nt_BP=444nt
ATGGAGAGGCAGAAACGGAAGGCGGACATCGAGAAAGGGCTGCAGTTCATTCAGTCGACACTACCCCTAAAGCAAGAAGAATATGAGGCC
TTTCTGCTCAAGCTGGTGCAGAATCTGTTTGCTGAGGGCAATGATCTGTTCCGGGAGAAGGACTATAAGCAGGCTCTGGTGCAGTACATG
GAAGGGCTGAACGTGGCCGACTACGCTGCCTCTGACCAGGTGGCCCTGCCCCGGGAGCTGCTGTGCAAGCTGCATGTCAATAGGGCCGCC
TGCTACTTCACCATGGGCCTGTATGAGAAGGCGCTGGAGGACAGCGAGAAGGCGCTGGGCCTGGACAGTGAGAGTATCCGGGCGTTGTTC
CGCAAGGCACGCGCTCTCAATGAACTGGGACGCCACAAGGAGGCCTACGAGTGCAGCAGCCGGTGTTCCCTCGCCCTGCCCCACATGGTG
GAGAGCATGAAGTACCCCTTTAGGCAGGGCATGCGGCTGGAAGTGGTGGACAAGTCCCAGGTGTCACGCACTCGCATGGCTGTGGTGGAC
ACAGTAATCGGGGGTCGCCTACGGCTCCTCTACGAGGATGGTGACAGTGACGACGACTTCTGGTGCCACATGTGGAGCCCCCTGATCCAC
CCAGTGGGTTGGTCACGACGTGTGGGCCACGGCATCAAGATGTCAGAGAGGCGAAGTGACATGGCCCATCACCCCACCTTCCGGAAGATC
TACTGTGATGCCGTTCCTTACCTCTTCAAGAAGGTACGAGCAGTCTACACAGAAGGCGGTTGGTTTGAGGAAGGGATGAAGCTGGAGGCC
ATTGACCCCCTGAATCTGGGCAACATCTGCGTGGCAACTGTCTGTAAGGTTCTCCTGGATGGATACCTGATGATCTGTGTGGACGGGGGG
CCCTCCACAGATGGCTTGGACTGGTTCTGCTACCATGCCTCTTCCCACGCCATCTTCCCGGCCACCTTCTGTCAGAAGAATGACATTGAG
CTCACACCGCCAAAAGGTTATGAGGCACAGACTTTCAACTGGGAGAACTACTTGGAGAAGACCAAGTCGAAAGCCGCTCCATCGAGACTC
TTTAACATGGATTGCCCAAACCATGGCTTCAAGGTGGGCATGAAGCTGGAGGCCGTGGACCTGATGGAGCCCCGGCTCATCTGTGTGGCC
ACGGTGAAACGAGTGGTGCATCGGCTCCTCAGCATCCACTTTGACGGCTGGGACAGCGAGTACGACCAGTGGGTGGACTGCGAGTCCCCA
GACATCTACCCCGTCGGCTGGTGTGAGCTCACCGGCTACCAGCTCCAGCCTCCTGTGGCCGCAGAACCGGCCACACCGCTGAAGGCCAAA
GAGGCCACAAAGAAGAAAAAGAAACAGTTTGGGAAGAAAAGGAAAAGAATCCCGCCCACTAAGACGCGACCCCTCAGACAGGGGTCCAAG
AAGCCCCTGCTGGAGGACGACCCTCAGGGTGCCAGGAAGATCTCGTCGGAGCCTGTTCCTGGCGAGATCATTGCTGTGCGTGTGAAGGAA
GAGCATCTAGACGTGGCCTCGCCCGACAAGGCTTCAAGTCCAGAGCTGCCTGTCTCCGTCGAGAACATCAAGCAGGAAACAGACGACTGA
GCCTTCCTGCCTCCAGCCTGGCTTCTAGCTGGAAGCCAGCCCAGCGTTTCTCTACCACCACCACCATGCCTCCACCTGACTTTGGCTTGG
AGACTGATCCTCTCTGTGTAAATTCTGCCCGGTGCTGTGAAGGCTGGACGGTGGAGGACCTGCTGGGGTCTCCTGGGACCCGCCTGTTGC
TTCTGCCCTCCCCTGTGGAAAGGTCTATATGACGGGCCGCCTGAGGCCCCAGAACTCGTCTGTGAACCACCTTTTCCAGCCAGAGTTCCC
AAAGCTGGAACGCTAGCTGCCTGCTCTTCCTTAAGATGGCCTCCCCCCGACCCGCCACGGCCCTCAGTTGCCAGGGATGGGGCCACCACT
GTCACACTGTGGAATACAAGACAGTGAACTCTGTCTGCCTGAACGAGCCATGTAAATTAAGTTCTAGAGCAGCTCTCTGAGCAGGATAAG
GTCCCCTGACAGTGAGTTGTGTGGTGGGGGCAGCCTCTGCCTCAAAAATTCACCAAGCAGAATGCCTCTCAGCCTCATGTGTTGGTCCTC
TGCTCCTCCTAGCTCCCCAGGGATGTTGGGGACCCAGCTTGTCTCGGCAGCTAAGAAGCAGTGACCAGGATGTGGATTTTGGCGACCTGT
GTGGTGGCCTTGAGCTGCTTTCTGTGTTTGTGAGGACTGACTCCCATTTCCTAAAGGAAATGCCCCCGGGGAGGACATTGGGAGGAAGAT
GGCCTGAGTGTGCACTTTGGCTCTGCTACCTGCTCCTGAAGCCCCGCTAAAAATAATTCATCCAAGATTCCTTTGTAGTTAAAGGGTCCA
GTTCTGACTGGAGCCTCTAGAGAGCTGGGCTTGTATGTTCTTTTGGCCTTTTGTTCCTACCTAAATGAAGAAACCATGCCTGGAGGGGCC
GTGAACACAGAACCCTCAAGACAAGGATGACAGAGCTGGAGGACACATCTAGCTGCCATTGCAACCTCACTGGGCTCCCCAGACTCTGTG

>In-frame_ENST00000351589_ENST00000216237_TCGA-2Y-A9H3-01A_ZC3H7B_chr22_41723368_-_L3MBTL2_chr22_41620024_length(amino acids)=539AA_start in transcript=0_stop in transcript=1619
MERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRAA
CYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHMVESMKYPFRQGMRLEVVDKSQVSRTRMAVVD
TVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSERRSDMAHHPTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLEA
IDPLNLGNICVATVCKVLLDGYLMICVDGGPSTDGLDWFCYHASSHAIFPATFCQKNDIELTPPKGYEAQTFNWENYLEKTKSKAAPSRL
FNMDCPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQPPVAAEPATPLKAK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZC3H7B-L3MBTL2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ZC3H7B-L3MBTL2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ZC3H7B-L3MBTL2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	L3MBTL2	C0025149	Medulloblastoma	1	CTD_human
Tgene	L3MBTL2	C0205833	Medullomyoblastoma	1	CTD_human
Tgene	L3MBTL2	C0278510	Childhood Medulloblastoma	1	CTD_human
Tgene	L3MBTL2	C0278876	Adult Medulloblastoma	1	CTD_human
Tgene	L3MBTL2	C0751291	Desmoplastic Medulloblastoma	1	CTD_human
Tgene	L3MBTL2	C1275668	Melanotic medulloblastoma	1	CTD_human