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Fusion gene:LATS2_CRYL1 (FusionGDB2 ID:HG26524TG51084) |
Fusion Gene Summary for LATS2_CRYL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LATS2_CRYL1 | Fusion gene ID: hg26524tg51084 | Hgene | Tgene | Gene symbol | LATS2 | CRYL1 | Gene ID | 26524 | 51084 |
| Gene name | large tumor suppressor kinase 2 | crystallin lambda 1 | |
| Synonyms | KPM | GDH|HEL30|gul3DH|lambda-CRY | |
| Cytomap | 13q12.11 | 13q12.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase LATS2LATS (large tumor suppressor, Drosophila) homolog 2LATS, large tumor suppressor, homolog 2kinase phosphorylated during mitosis proteinlarge tumor suppressor homolog 2serine/threonine kinase KPMserine/threonine-pr | lambda-crystallin homologL-gulonate 3-dehydrogenasecrystallin, lamda 1epididymis luminal protein 30testicular tissue protein Li 44 | |
| Modification date | 20240407 | 20240403 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000382592, ENST00000542899, ENST00000472754, | ||
| Fusion gene scores | * DoF score | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 11 X 29 X 8=2552 | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 12 X 14 X 13=2184 |
| # samples | 28 | 27 | |
| ** MAII score | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(28/2552*10)=-3.1881295968199 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(27/2184*10)=-3.01594154386902 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LATS2 [Title/Abstract] AND CRYL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | LATS2(21619823)-CRYL1(21063635), # samples:1 | ||
| Fusion gene breakpoints across LATS2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CRYL1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Breakpoints for LATS2_CRYL1 |
| RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| LATS2 | chr13 | 21619823 | CRYL1 | chr13 | 21063635 |
| DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | SV type |
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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for LATS2_CRYL1 |
| To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence. |
| Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions | Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity | Epigenetic Reprogramming / Histone Modifier Dysregulation | Chromatin Remodeling Dysregulation | Condensate-Driven Transcriptional Rewiring / LLP | Promoter / Enhancer Hijacking | Dominant-Negative Antagonism | Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation | Subcellular Mislocalization / Spatial Dysregulation | Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade |  |  |  |  |  |  |  |  |  |  |
* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
| LATS2-CRYL1 | Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions M1 | Disruption of LATS2 Hippo tumor suppressor kinase pairs with CRYL1 expression, perturbing cell cycle control and metabolic signaling. | YAP/TEAD inhibitors (verteporfin); metabolic blockers | Aneuploid solid tumors and carcinomas |
* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
| LATS2-CRYL1 | Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions M1 | Disruption of LATS2 Hippo tumor suppressor kinase pairs with CRYL1 expression, perturbing cell cycle control and metabolic signaling. | Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 16075462; Title: Molecular genetic evidence supporting a novel human hepatocellular carcinoma tumor suppressor locus at 13q12.11.; PMID: 19927314; Title: Reduced CRYL1 expression in hepatocellular carcinoma confers cell growth advantages and correlates with adverse patient prognosis. | YAP/TEAD inhibitors (verteporfin); metabolic blockers | Aneuploid solid tumors and carcinomas | Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 16075462; Title: Molecular genetic evidence supporting a novel human hepatocellular carcinoma tumor suppressor locus at 13q12.11.; PMID: 19927314; Title: Reduced CRYL1 expression in hepatocellular carcinoma confers cell growth advantages and correlates with adverse patient prognosis. |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LATS2 | GO:0000082 | G1/S transition of mitotic cell cycle | 12853976 |
| Hgene | LATS2 | GO:0006468 | protein phosphorylation | 10871863 |
| Hgene | LATS2 | GO:0009755 | hormone-mediated signaling pathway | 15131260 |
| Hgene | LATS2 | GO:0035329 | hippo signaling | 20412773 |
| Hgene | LATS2 | GO:0035556 | intracellular signal transduction | 10871863 |
| Hgene | LATS2 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity | 12853976 |
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Fusion Genomic Features for LATS2_CRYL1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| LATS2 | chr13 | 21619823 | - | CRYL1 | chr13 | 21063635 | - | 7.91e-08 | 1.00e+00 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF). |
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Fusion Gene ORF Annotations for LATS2_CRYL1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000542899 | ENST00000298248 | LATS2 | chr13 | 21619823 | - | CRYL1 | chr13 | 21063635 | - |
| Frame-shift | ENST00000542899 | ENST00000382812 | LATS2 | chr13 | 21619823 | - | CRYL1 | chr13 | 21063635 | - |
| In-frame | ENST00000382592 | ENST00000298248 | LATS2 | chr13 | 21619823 | - | CRYL1 | chr13 | 21063635 | - |
| In-frame | ENST00000382592 | ENST00000382812 | LATS2 | chr13 | 21619823 | - | CRYL1 | chr13 | 21063635 | - |
| ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ENST00000382592 | ENST00000298248 | LATS2 | chr13 | 21619823 | CRYL1 | chr13 | 21063635 | 748 | 541 |
| ENST00000382592 | ENST00000382812 | LATS2 | chr13 | 21619823 | CRYL1 | chr13 | 21063635 | 748 | 267 |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| ENST00000382592 | ENST00000298248 | LATS2 | chr13 | 21619823 | CRYL1 | chr13 | 21063635 | 2.90e-03 | 9.97e-01 |
| ENST00000382592 | ENST00000382812 | LATS2 | chr13 | 21619823 | CRYL1 | chr13 | 21063635 | 2.89e-03 | 9.97e-01 |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
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Fusion Protein Retained/Non-Retained Functional Features for LATS2_CRYL1 |
| Protein Level Annotation from FGviewer * Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS. |
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| - In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length). |
LATS2_CRYL1_chr13-21619823_chr13-21063635.png |
| - In-frame and retained protein feature among the 13 regional features (texts). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LATS2 | chr13:21619823 | chr13:21063635 | ENST00000382592 | Q9NRM7 | 2 | 8 | 24_49 | 114.0 | 1089.0 | Region | Disordered |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LATS2 | chr13:21619823 | chr13:21063635 | ENST00000382592 | Q9NRM7 | 2 | 8 | 271_280 | 114.0 | 1089.0 | Compositional bias | Polar residues |
| Hgene | LATS2 | chr13:21619823 | chr13:21063635 | ENST00000382592 | Q9NRM7 | 2 | 8 | 404_413 | 114.0 | 1089.0 | Compositional bias | Polar residues |
| Hgene | LATS2 | chr13:21619823 | chr13:21063635 | ENST00000382592 | Q9NRM7 | 2 | 8 | 466_478 | 114.0 | 1089.0 | Compositional bias | Pro residues |
| Hgene | LATS2 | chr13:21619823 | chr13:21063635 | ENST00000382592 | Q9NRM7 | 2 | 8 | 553_572 | 114.0 | 1089.0 | Compositional bias | Basic and acidic residues |
| Hgene | LATS2 | chr13:21619823 | chr13:21063635 | ENST00000382592 | Q9NRM7 | 2 | 8 | 583_592 | 114.0 | 1089.0 | Compositional bias | Basic and acidic residues |
| Hgene | LATS2 | chr13:21619823 | chr13:21063635 | ENST00000382592 | Q9NRM7 | 2 | 8 | 668_973 | 114.0 | 1089.0 | Domain | Protein kinase |
| Hgene | LATS2 | chr13:21619823 | chr13:21063635 | ENST00000382592 | Q9NRM7 | 2 | 8 | 974_1052 | 114.0 | 1089.0 | Domain | AGC-kinase C-terminal |
| Hgene | LATS2 | chr13:21619823 | chr13:21063635 | ENST00000382592 | Q9NRM7 | 2 | 8 | 98_139 | 114.0 | 1089.0 | Domain | UBA |
| Hgene | LATS2 | chr13:21619823 | chr13:21063635 | ENST00000382592 | Q9NRM7 | 2 | 8 | 515_518 | 114.0 | 1089.0 | Motif | Note=PPxY motif |
| Hgene | LATS2 | chr13:21619823 | chr13:21063635 | ENST00000382592 | Q9NRM7 | 2 | 8 | 1056_1088 | 114.0 | 1089.0 | Region | Disordered |
| Hgene | LATS2 | chr13:21619823 | chr13:21063635 | ENST00000382592 | Q9NRM7 | 2 | 8 | 271_323 | 114.0 | 1089.0 | Region | Disordered |
| Hgene | LATS2 | chr13:21619823 | chr13:21063635 | ENST00000382592 | Q9NRM7 | 2 | 8 | 383_428 | 114.0 | 1089.0 | Region | Disordered |
| Hgene | LATS2 | chr13:21619823 | chr13:21063635 | ENST00000382592 | Q9NRM7 | 2 | 8 | 454_483 | 114.0 | 1089.0 | Region | Disordered |
| Hgene | LATS2 | chr13:21619823 | chr13:21063635 | ENST00000382592 | Q9NRM7 | 2 | 8 | 543_592 | 114.0 | 1089.0 | Region | Disordered |
| Hgene | LATS2 | chr13:21619823 | chr13:21063635 | ENST00000382592 | Q9NRM7 | 2 | 8 | 994_1022 | 114.0 | 1089.0 | Region | Disordered |
| - Retained PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | LATS2 | chr13:21619823 | CRYL1 | chr13:21063635 | ENST00000382592 | Q9NRM7 | 2 | 8 | 101_141 | 114.0 | 1089.0 | Region | ubiquitinated AMOTL2 |
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Fusion Transcript Sequence for LATS2_CRYL1 |
| In-frame Fusion Transcript Sequences. |
>LATS2_CRYL1_ENST00000382592_ENST00000298248_21619823_21063635 length=2021nt Breakpoint=748nt TTGGGTCTGCGCTTTGGAACCGCGGCGTGAGCGCCCCGGGAAGATGGAGCAGTCGCCGTCCACGCCACCGCCGCCGCCCGGGGCTCCCCCGTCCCTGCGGGGCCAGCAGCAGCTCCAGCCACCAGTGCCCGGTCTCCCGGCGCGAGAGGC CCGGGAGCCGCCGGCCAGGACGCCCCCGAGGGTGTAGACCGCGCCCCTGGAGAGAGTGATAATCTTCAAAATGAAGACTTTGGAAAATTTTAGGTTCTCTATAGGAACTACAAAAATGGAAGGAAAGAACATTTTCAAAAGGAAATTATT TTGAAAGTATGTTTACAACAAACTGATACTATTGACAGTTTTTTTTTTTAAATAATAAAACACTTTAAGAAGATTGTATTTATGGTAAAAGGAAACTGGACTAACAATGAGGCCAAAGACTTTTCCTGCCACGACTTATTCTGGAAATAG CCGGCAGCGACTGCAAGAGATTCGTGAGGGGTTAAAACAGCCATCCAAGTCTTCGGTTCAGGGGCTACCCGCAGGACCAAACAGTGACACTTCCCTGGATGCCAAAGTCCTGGGGAGCAAAGATGCCACCAGGCAGCAGCAGCAGATGAG AGCCACCCCAAAGTTCGGACCTTATCAGAAAGCCTTGAGGGAAATCAGATATTCCTTGTTGCCTTTTGCTAATGAATCGGGCACCTCTGCAGCTGCAGAAGTGAACCGGCAAATGCTGCAGGAACTGGTGAACGCAGGATGCGACCAGAA AGGAGATGAAGTTGCTGGAGCAGGCAGGTTCTCTGAAAGGCTCCCTGAGTGTGGAAGAGCAGCTGTCACTCATCAGTGGTTGTCCCAATATCCAAGAAGCAGTAGAGGGTGCCATGCACATTCAGGAATGTGTTCCAGAAGATCTAGAAC TGAAGAAGAAGATTTTTGCTCAGTTAGATTCCATCATTGATGATCGAGTGATCTTAAGCAGTTCCACTTCTTGTCTCATGCCTTCCAAGTTGTTTGCTGGCTTGGTCCATGTGAAGCAATGCATCGTGGCTCATCCTGTGAATCCGCCAT ACTACATCCCGCTGGTTGAGCTGGTCCCCCACCCGGAGACGGCCCCTACGACAGTGGACAGAACCCACGCCCTGATGAAGAAGATTGGACAGTGCCCCATGCGAGTCCAGAAGGAGGTGGCCGGCTTCGTTCTGAACCGCCTGCAATATG CAATCATCAGCGAGGCCTGGCGGCTAGTGGAGGAAGGAATCGTGTCTCCTAGTGACCTGGACCTTGTCATGTCAGAAGGGTTGGGCATGCGGTATGCATTCATTGGACCCCTGGAAACCATGCATCTCAATGCAGAAGGTATGTTAAGCT ACTGCGACAGATACAGCGAAGGCATAAAACATGTCCTACAGACTTTTGGACCCATTCCAGAGTTTTCCAGGGCCACTGCTGAGAAGGTTAACCAGGACATGTGCATGAAGGTCCCTGATGACCCGGAGCACTTAGCTGCCAGGAGGCAGT GGAGGGACGAGTGCCTCATGAGACTCGCCAAGTTGAAGAGTCAAGTGCAGCCCCAGTGAATTTCTTGTAATGCAGCTTCCACTCCTCTCATTGGAGGCCCTATTTGGGAACACTGCAAGCCCTTAATCAGCCCTCTGTGACATAGGTAGC AGCCCACGGAGATCCTAAGCTGGCTGTCTTGTGTGCAGCCTGAGTGGGGTGGTGCAGGCCGGTAGTCTGCCCGTCACTTTGGATCATAGCCCTGGGCCTGGCGGCACAGCAGCACTTGCGTTCTCGGGGCTGTCGATTTCCTGCCACCTG GGCAGATAACCTGGAGATTTTCACCTTTTCTTTTCAGCTTGATTGCATTTGACTATATTTTACAGCCAGTGATTGTAGTTTCATGTTAATATGTGGCAAAATATTTTTGTAATTATTTTCTAATCCCTTTCTGAGTACTCTGGGGCCCTG CATTTATGAGGCACCTACCTTCATTTTGCTAACGCTTATTCTGAATAAAAGTTTTTGATTCCTTAAAGACA >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635 length=2017nt Breakpoint=748nt TTGGGTCTGCGCTTTGGAACCGCGGCGTGAGCGCCCCGGGAAGATGGAGCAGTCGCCGTCCACGCCACCGCCGCCGCCCGGGGCTCCCCCGTCCCTGCGGGGCCAGCAGCAGCTCCAGCCACCAGTGCCCGGTCTCCCGGCGCGAGAGGC CCGGGAGCCGCCGGCCAGGACGCCCCCGAGGGTGTAGACCGCGCCCCTGGAGAGAGTGATAATCTTCAAAATGAAGACTTTGGAAAATTTTAGGTTCTCTATAGGAACTACAAAAATGGAAGGAAAGAACATTTTCAAAAGGAAATTATT TTGAAAGTATGTTTACAACAAACTGATACTATTGACAGTTTTTTTTTTTAAATAATAAAACACTTTAAGAAGATTGTATTTATGGTAAAAGGAAACTGGACTAACAATGAGGCCAAAGACTTTTCCTGCCACGACTTATTCTGGAAATAG CCGGCAGCGACTGCAAGAGATTCGTGAGGGGTTAAAACAGCCATCCAAGTCTTCGGTTCAGGGGCTACCCGCAGGACCAAACAGTGACACTTCCCTGGATGCCAAAGTCCTGGGGAGCAAAGATGCCACCAGGCAGCAGCAGCAGATGAG AGCCACCCCAAAGTTCGGACCTTATCAGAAAGCCTTGAGGGAAATCAGATATTCCTTGTTGCCTTTTGCTAATGAATCGGGCACCTCTGCAGCTGCAGAAGTGAACCGGCAAATGCTGCAGGAACTGGTGAACGCAGGATGCGACCAGAA AGGAGATGAAGTTGCTGGAGCAGGCAGGTTCTCTGAAAGGCTCCCTGAGTGTGGAAGAGCAGCTGTCACTCATCAGTGGTTGTCCCAATATCCAAGAAGCAGTAGAGGGTGCCATGCACATTCAGGAATGTGTTCCAGAAGATCTAGAAC TGAAGAAGAAGATTTTTGCTCAGTTAGATTCCATCATTGATGATCGAGTGATCTTAAGCAGTTCCACTTCTTGTCTCATGCCTTCCAAGTTGTTTGCTGGCTTGGTCCATGTGAAGCAATGCATCGTGGCTCATCCTGTGAATCCGCCAT ACTACATCCCGCTGGTTGAGCTGGTCCCCCACCCGGAGACGGCCCCTACGACAGTGGACAGAACCCACGCCCTGATGAAGAAGATTGGACAGTGCCCCATGCGAGTCCAGAAGGAGGTGGCCGGCTTCGTTCTGAACCGCCTGCAATATG CAATCATCAGCGAGGCCTGGCGGCTAGTGGAGGAAGGAATCGTGTCTCCTAGTGACCTGGACCTTGTCATGTCAGAAGGGTTGGGCATGCGGTATGCATTCATTGGACCCCTGGAAACCATGCATCTCAATGCAGAAGGTATGTTAAGCT ACTGCGACAGATACAGCGAAGGCATAAAACATGTCCTACAGACTTTTGGACCCATTCCAGAGTTTTCCAGGGCCACTGCTGAGAAGGTTAACCAGGACATGTGCATGAAGGTCCCTGATGACCCGGAGCACTTAGCTGCCAGGAGGCAGT GGAGGGACGAGTGCCTCATGAGACTCGCCAAGTTGAAGAGTCAAGTGCAGCCCCAGTGAATTTCTTGTAATGCAGCTTCCACTCCTCTCATTGGAGGCCCTATTTGGGAACACTGCAAGCCCTTAATCAGCCCTCTGTGACATAGGTAGC AGCCCACGGAGATCCTAAGCTGGCTGTCTTGTGTGCAGCCTGAGTGGGGTGGTGCAGGCCGGTAGTCTGCCCGTCACTTTGGATCATAGCCCTGGGCCTGGCGGCACAGCAGCACTTGCGTTCTCGGGGCTGTCGATTTCCTGCCACCTG GGCAGATAACCTGGAGATTTTCACCTTTTCTTTTCAGCTTGATTGCATTTGACTATATTTTACAGCCAGTGATTGTAGTTTCATGTTAATATGTGGCAAAATATTTTTGTAATTATTTTCTAATCCCTTTCTGAGTACTCTGGGGCCCTG CATTTATGAGGCACCTACCTTCATTTTGCTAACGCTTATTCTGAATAAAAGTTTTTGATTCCTTAAA |
| N-Truncated Transcript (5UTR-3CDS) Sequences |
| C-Truncated Transcript (5CDS-3UTR) Sequences |
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Fusion Protein Sequence for LATS2_CRYL1 |
| In-frame Fusion Protein Sequences. |
>LATS2_CRYL1_ENST00000382592_ENST00000298248_21619823_21063635 length=541nt MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNDAVMLHSFTLRQQLQTTRQELSHALYQHDAA CRVIARLTKEVTAAREALATLKPQAGLIVPQAVPSSQPSVVGAGEPMDLGELVGMTPEIIQKLQDKATVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGH TKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADD SSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635 length=267nt MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ |
| N-Truncated Protein (5UTR-3CDS) Sequences |
| C-Truncated Protein (5CDS-3UTR) Sequences |
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Personalized Fusion Protein Sequence for LATS2_CRYL1 |
| TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| TCGA All Mutated Fusion Protein Sequences |
>LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.R116Q_267_R64Q length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDQVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.S65F_267_S13F length=267AA MKLLEQAGSLKGFLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.D221Y_267_D169Y length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLYLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.I235L_267_I183L length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFLGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.V169M_267_V117M length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTMDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.S216F_267_S164F length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVFPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.R197C_267_R145C length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNCLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.E257K_267_E205K length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSKGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.A310T_267_A258T length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLTKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.P166L_267_P114L length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETALTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.D253N_267_D201N length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCNRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.E189D_267_E137D length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKDVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.K104T_267_K52T length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKTIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.R197C_267_R145C length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNCLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.R185Q_267_R133Q length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMQVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.R185Q_267_R133Q length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMQVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.K260Q_267_K208Q length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIQHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.P268L_267_P216L length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGLIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.V143M_267_V91M length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIMAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.P162L_267_P110L length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHLETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.E86K_267_E34K length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVKGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.H161Y_267_H109Y length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPYPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.Y232H_267_Y180H length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRHAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.I203T_267_I151T length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI TSEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.A174V_267_A122V length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHVLMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.L238M_267_L186M length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPMETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.E189K_267_E137K length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKKVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.Q187H_267_Q135H length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVHKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.R197H_267_R145H length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNHLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.L99V_267_L47V length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDVELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.A297V_267_A245V length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAVRRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.L243F_267_L191F length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHFNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.E246K_267_E194K length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAKGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.P154L_267_P102L length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYILLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.L135F_267_L83F length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGFVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.T172N_267_T120N length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRNHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.A201V_267_A149V length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYVI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.K139N_267_K87N length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVNQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.E163Q_267_E111Q length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPQTAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.R231Q_267_R179Q length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIVSPSDLDLVMSEGLGMQYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ >LATS2_CRYL1_ENST00000382592_ENST00000382812_21619823_21063635_3-gene_p.V215M_267_V163M length=267AA MKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAI ISEAWRLVEEGIMSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-06-5416-01A | 3-gene | p.R116Q | 267 | R64Q |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-50-5930-01A | 3-gene | p.S65F | 267 | S13F |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-63-5128-01A | 3-gene | p.D221Y | 267 | D169Y |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-A2-A0D0-01A | 3-gene | p.I235L | 267 | I183L |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-A5-A1OF-01A | 3-gene | p.V169M | 267 | V117M |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-A6-3808-01A | 3-gene | p.S216F | 267 | S164F |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-AA-3663-01A | 3-gene | p.R197C | 267 | R145C |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-AA-3984-01A | 3-gene | p.E257K | 267 | E205K |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-AA-A00N-01A | 3-gene | p.A310T | 267 | A258T |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-AA-A02F-01A | 3-gene | p.P166L | 267 | P114L |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-AG-4001-01A | 3-gene | p.D253N | 267 | D201N |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-AP-A059-01A | 3-gene | p.E189D | 267 | E137D |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-AP-A1DK-01A | 3-gene | p.K104T | 267 | K52T |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-AX-A1CE-01A | 3-gene | p.R197C | 267 | R145C |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-AX-A2HC-01A | 3-gene | p.R185Q | 267 | R133Q |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-AX-A2HD-01A | 3-gene | p.R185Q | 267 | R133Q |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-B5-A11E-01A | 3-gene | p.K260Q | 267 | K208Q |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-B5-A3FA-01A | 3-gene | p.P268L | 267 | P216L |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-B5-A3FC-01A | 3-gene | p.V143M | 267 | V91M |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-BR-6852-01A | 3-gene | p.P162L | 267 | P110L |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-C5-A7XC-01A | 3-gene | p.E86K | 267 | E34K |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-CI-6624-01C | 3-gene | p.H161Y | 267 | H109Y |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-D8-A1XK-01A | 3-gene | p.Y232H | 267 | Y180H |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-DE-A4MB-01A | 3-gene | p.I203T | 267 | I151T |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-EB-A6QY-01A | 3-gene | p.A174V | 267 | A122V |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-EE-A2ME-06A | 3-gene | p.L238M | 267 | L186M |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-EK-A3GK-01A | 3-gene | p.E189K | 267 | E137K |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-EO-A22R-01A | 3-gene | p.Q187H | 267 | Q135H |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-EO-A3B0-01A | 3-gene | p.R197H | 267 | R145H |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-EO-A3KX-01A | 3-gene | p.L99V | 267 | L47V |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-F4-6856-01A | 3-gene | p.A297V | 267 | A245V |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-FI-A2D0-01A | 3-gene | p.L243F | 267 | L191F |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-FI-A2D5-01A | 3-gene | p.E246K | 267 | E194K |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-FR-A726-01A | 3-gene | p.P154L | 267 | P102L |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-HU-A4GX-01A | 3-gene | p.L135F | 267 | L83F |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-KK-A8ID-01A | 3-gene | p.T172N | 267 | T120N |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-X6-A7WB-01A | 3-gene | p.A201V | 267 | A149V |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-XF-AAME-01A | 3-gene | p.K139N | 267 | K87N |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-XF-AAML-01A | 3-gene | p.E163Q | 267 | E111Q |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-XF-AAMR-01A | 3-gene | p.R231Q | 267 | R179Q |
| ENST00000382592_ENST00000382812_21619823_21063635 | TCGA-XK-AAIW-01A | 3-gene | p.V215M | 267 | V163M |
| CCLE All Mutated Fusion Protein Sequences |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
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Fusion Gene Exprssed Samples for LATS2_CRYL1 |
| RNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB | STAD | TCGA-D7-8570-01A | LATS2 | chr13 | 21619823 | - | CRYL1 | chr13 | 21063635 | - |
| DNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | SV type |
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Related Drugs for LATS2_CRYL1 |
| PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug'] * For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub. |
| PMID | Fusion Gene Name | Drug | Study Title |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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