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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:FAM83G_TTC19 (FusionGDB2 ID:HG644815TG54902)

Fusion Gene Summary for FAM83G_TTC19

Fusion gene summary

Fusion gene information	Fusion gene name: FAM83G_TTC19
	Fusion gene ID: hg644815tg54902
		Hgene	Tgene
	Gene symbol	FAM83G	TTC19
	Gene ID	644815	54902
	Gene name	family with sequence similarity 83 member G	tetratricopeptide repeat domain 19
	Synonyms	PAWS1	2010204O13Rik\|MC3DN2
	Cytomap	17p11.2	17p12
	Type of gene	protein-coding	protein-coding
	Description	protein FAM83Gprotein associated with SMAD1	tetratricopeptide repeat protein 19, mitochondrialTPR repeat protein 19
	Modification date	20240305	20240407
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000345041, ENST00000388995, ENST00000585154,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 10 X 8 X 9=720	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 2 X 10 X 6=120
	# samples	13	11
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(13/72010)=-2.46948528330122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(11/12010)=-0.125530882083859 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FAM83G [Title/Abstract] AND TTC19 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FAM83G(18891559)-TTC19(15928330), # samples:1

Fusion gene breakpoints across FAM83G (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TTC19 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for FAM83G_TTC19

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
FAM83G	chr17	18891559	TTC19	chr17	18891559
FAM83G	chr17	18891560	TTC19	chr17	15928331
FAM83G	chr17	18988247	TTC19	chr17	16025017

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for FAM83G_TTC19

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FAM83G	GO:0030509	BMP signaling pathway	24554596

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Fusion Genomic Features for FAM83G_TTC19

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
FAM83G	chr17	18891559	-	TTC19	chr17	15928330	+	4.92e-06	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for FAM83G_TTC19

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000345041	ENST00000497842	FAM83G	chr17	18891559	-	TTC19	chr17	15928330	+
5CDS-3UTR	ENST00000388995	ENST00000497842	FAM83G	chr17	18891559	-	TTC19	chr17	15928330	+
5CDS-3UTR	ENST00000585154	ENST00000497842	FAM83G	chr17	18891559	-	TTC19	chr17	15928330	+
Frame-shift	ENST00000345041	ENST00000261647	FAM83G	chr17	18891559	-	TTC19	chr17	15928330	+
Frame-shift	ENST00000345041	ENST00000486880	FAM83G	chr17	18891559	-	TTC19	chr17	15928330	+
Frame-shift	ENST00000585154	ENST00000261647	FAM83G	chr17	18891559	-	TTC19	chr17	15928330	+
Frame-shift	ENST00000585154	ENST00000486880	FAM83G	chr17	18891559	-	TTC19	chr17	15928330	+
In-frame	ENST00000388995	ENST00000261647	FAM83G	chr17	18891559	-	TTC19	chr17	15928330	+
In-frame	ENST00000388995	ENST00000486880	FAM83G	chr17	18891559	-	TTC19	chr17	15928330	+

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000388995	ENST00000261647	FAM83G	chr17	18891559	TTC19	chr17	15928330	914	242
ENST00000388995	ENST00000486880	FAM83G	chr17	18891559	TTC19	chr17	15928330	914	244

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000388995	ENST00000261647	FAM83G	chr17	18891559	TTC19	chr17	15928330	3.48e-03	9.97e-01
ENST00000388995	ENST00000486880	FAM83G	chr17	18891559	TTC19	chr17	15928330	2.35e-03	9.98e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000345041	ENST00000497842	FAM83G	chr17	18891559	TTC19	chr17	15928330	0.00e+00	1.52e-03
ENST00000388995	ENST00000497842	FAM83G	chr17	18891559	TTC19	chr17	15928330	0.00e+00	2.04e-03
ENST00000585154	ENST00000497842	FAM83G	chr17	18891559	TTC19	chr17	15928330	0.00e+00	1.54e-03

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Fusion Protein Retained/Non-Retained Functional Features for FAM83G_TTC19

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

FAM83G_TTC19_chr17-18891559_chr17-15928330.png

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FAM83G

chr17:18891559

chr17:15928330

ENST00000388995

A6ND36

75_108

230.0

824.0

Region

Disordered

Tgene

TTC19

chr17:18891559

chr17:15928330

ENST00000261647

Q6DKK2

237_270

225.33333333333334

381.0

Repeat

Note=TPR 3

Tgene

TTC19

chr17:18891559

chr17:15928330

ENST00000261647

Q6DKK2

279_312

225.33333333333334

381.0

Repeat

Note=TPR 4

Tgene

TTC19

chr17:18891559

chr17:15928330

ENST00000261647

Q6DKK2

318_351

225.33333333333334

381.0

Repeat

Note=TPR 5

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FAM83G

chr17:18891559

chr17:15928330

ENST00000388995

A6ND36

452_465

230.0

824.0

Compositional bias

Polar residues

Hgene

FAM83G

chr17:18891559

chr17:15928330

ENST00000388995

A6ND36

497_508

230.0

824.0

Compositional bias

Pro residues

Hgene

FAM83G

chr17:18891559

chr17:15928330

ENST00000388995

A6ND36

529_543

230.0

824.0

Compositional bias

Basic and acidic residues

Hgene

FAM83G

chr17:18891559

chr17:15928330

ENST00000388995

A6ND36

578_587

230.0

824.0

Compositional bias

Acidic residues

Hgene

FAM83G

chr17:18891559

chr17:15928330

ENST00000388995

A6ND36

672_681

230.0

824.0

Compositional bias

Basic and acidic residues

Hgene

FAM83G

chr17:18891559

chr17:15928330

ENST00000388995

A6ND36

809_823

230.0

824.0

Compositional bias

Basic and acidic residues

Hgene

FAM83G

chr17:18891559

chr17:15928330

ENST00000388995

A6ND36

2_312

230.0

824.0

Region

DUF1669

Hgene

FAM83G

chr17:18891559

chr17:15928330

ENST00000388995

A6ND36

450_823

230.0

824.0

Region

Disordered

Tgene

TTC19

chr17:18891559

chr17:15928330

ENST00000261647

Q6DKK2

136_169

225.33333333333334

381.0

Repeat

Note=TPR 1

Tgene

TTC19

chr17:18891559

chr17:15928330

ENST00000261647

Q6DKK2

179_212

225.33333333333334

381.0

Repeat

Note=TPR 2

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for FAM83G_TTC19

In-frame Fusion Transcript Sequences.

>FAM83G_TTC19_ENST00000388995_ENST00000261647_18891559_15928330 length=2771nt 
 Breakpoint=914nt
AGCGGGGCGGCCCTGAGTCACCGGCGCGCCCCCGCCCAGCCTCGCGCCGCCGCCGCAGCCGCCGCGTGTGCGCCCCGCTCCGCCAGCGCCCGCTCGATTGCTCATGGGCAGAGAAGCAGAGGCCGCGGAGAGGCCCCCGAGCGCGCGGTG
CCCCAGCTGGGCCGGAGCTAGGAGCTGGACCTTGCCCACCCACCCCCGGCAGCAGTGCCCGGGCAGGCGGCGCCATGGCCTTCTCTCAGGTGCAGTGTCTGGACGACAACCATGTGAACTGGCGCTCCAGCGAGTCCAAGCCTGAGTTCT
TCTACAGCGAGGAGCAGCGGCTGGCGCTGGAGGCCCTGGTGGCCCGCGGCCGGGACGCCTTCTACGAGGTGCTCAAGCGGGAGAACATCCGAGACTTCCTCTCGGAGCTGGAGCTCAAGCGCATCCTGGAGACCATCGAGGTGTACGACC
CGGGCTCTGAGGACCCTCGGGGCACGGGCCCCTCTCAGGGGCCCGAGGACAATGGGGTCGGCGACGGCGAGGAAGCCAGCGGGGCGGATGGGGTCCCCATCGAGGCCGAGCCGCTGCCCTCCCTGGAGTACTGGCCCCAGAAGTCGGACC
GCTCCATCCCGCAGCTGGACCTGGGCTGGCCCGACACCATCGCCTACCGCGGCGTGACCCGGGCTAGCGTCTACATGCAGCCCCCCATAGACGGGCAGGCCCACATCAAAGAGGTGGTGCGGAAGATGATCAGCCAGGCACAGAAGGTGA
TAGCTGTGGTCATGGACATGTTCACCGACGTGGACATCTTCAAGGACCTGCTGGACGCCGGCTTCAAGAGGAAAGTGGCCGTGTACATCATCGTGGATGAGAGTAACGTCAAGTACTTCCTGCACATGTGTGAGCGGGCCTGCATGCACC
TGGGGCACCTCAAGTGGAAGAGAAAGCCAATACCCACCTCCTCTTGGGCATGTGCTTAGACGCCTGTGCTCGCTACCTTCTGTTCTCCAAGCAGCCGTCACAGGCACAAAGGATGTATGAAAAAGCTCTGCAGATTTCTGAAGAAATACA
AGGAGAAAGACACCCACAGACCATTGTGCTGATGAGTGACCTGGCTACTACCCTGGATGCACAGGGCCGCTTTGATGAGGCCTATATTTATATGCAAAGGGCATCAGATCTGGCAAGACAGATAAATCATCCTGAGCTACACATGGTACT
CAGTAATCTAGCTGCAGTTTTGATGCACAGAGAACGATATACACAAGCAAAAGAGATCTACCAGGAAGCACTGAAGCAAGCAAAGCTGAAAAAAGATGAAATTTCTGTACAACACATCAGGGAAGAGTTGGCTGAGCTGTCAAAGAAAAG
TAGACCTTTGACAAATTCTGTCAAGCTCTAAATCCATTTTTGTGTAGGGAGAATAATGTCTAGTAATGTGGAAGAATAGCTATCATTCCTGTCTCTGTGGCACCCGATCAATGGCTTAAATCTGTCGTTTTTGATATTCAGGTTTCCTCA
ATTTAGCCTTAGTGAAGGAGGGGTTGTACACACTGCCATTTTTGTATTTTAAAGGAAAAATGACTTTCATTCCCAACTGATTATGACCTTTCAGGATGTCGTCAAGTGATGCTTTCAGTTGTAACACGTGACTTGGTGCTGTCCCTGCTG
GTCTAAGTAGAACTGTAGATTCATATGGGCTGGTGTTCCTGTGCGCTGTGGGTGTGGTGATTCAGCCTGGCATTTCTACCATAAGTTTTTGGTCTGCTGATTTGCTGCCCTGTCTTCTCTTACTTTACTTTATCAATACCTGGCAAACTG
ACCAGAATTACCTTCCTCATGGCAAAGGGGGATTATGGTGAATTGTTGTTCTTATAGTCTGTTTCATGAAGCACAAGTGGAATTTAATACATAAAAGAGAAAAATATCTTAGTTTGCTACCAGCATCCAGCATGAAGTTGTAAAGTGGGG
ATTAGGCACGTGACAGTATAGCACCCATTTGAATTTAAATAAAAGTGAACCATATTTATCTGGTTATATAAAACTAAAAATGGGGGTGTTTATATAAAACTAAAAACTAAGAATGATGTAACCTTTTGTCTGTGTTATCTGAACACTCTA
CTTCCTTTGCAGCCTTAGTCACACAACTGAGTCATCTCAAGTACTCTTTAAGGACACACAGCCCAGGCTGTTCTGAGTCAGAATAGGCCCCTACAGGTATATTTTAAAACTCTTCGTAATTCTAATGTGTACTGCTGGTATAGCTGAACT
ACTGACCTGGATCTTAGTCCTAGCCTTTTTGCTTTTGCAATTTCAGTATCTTCATCTCTAAACTAGGGAAACACTGGGATTCTTTCTTAGCTGTGGGGGAAGGTATTTGGTTAGATGACTTTGAATGAATAGACTGCTGTGCTGAAAGAG
CTTTATCACACTGTCTCAAAGTATGTAAAGATACATAGGTGGATGCTCTTACTGCAGCAGTCATGAATACATTTTTAGCCATTTACCTAAGGAAAAAGACAGTTTTTCTAGGTACCATGAAGGAAGATTGACCCTGTTGGTATGCCTGTG
GGGGTGGGATGTGAGTGGGACTGATAAACTGATACTTTTGGTTCGTATGTACATACTGGAAGAATCTTCATAATAAATGAGACTACACAACAATATTGTATGTATCCCAGTAATCTTTGCATTTCTCAAAAAAAAAAAAAAAAAAAAAAA
AAAAACTTTCTGAAGAAAATAAAAACACCAGAAACCTTGAGGTCCAAATCCTCAGGGATTAGACTAAAACT

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330 length=2641nt 
 Breakpoint=914nt
AGCGGGGCGGCCCTGAGTCACCGGCGCGCCCCCGCCCAGCCTCGCGCCGCCGCCGCAGCCGCCGCGTGTGCGCCCCGCTCCGCCAGCGCCCGCTCGATTGCTCATGGGCAGAGAAGCAGAGGCCGCGGAGAGGCCCCCGAGCGCGCGGTG
CCCCAGCTGGGCCGGAGCTAGGAGCTGGACCTTGCCCACCCACCCCCGGCAGCAGTGCCCGGGCAGGCGGCGCCATGGCCTTCTCTCAGGTGCAGTGTCTGGACGACAACCATGTGAACTGGCGCTCCAGCGAGTCCAAGCCTGAGTTCT
TCTACAGCGAGGAGCAGCGGCTGGCGCTGGAGGCCCTGGTGGCCCGCGGCCGGGACGCCTTCTACGAGGTGCTCAAGCGGGAGAACATCCGAGACTTCCTCTCGGAGCTGGAGCTCAAGCGCATCCTGGAGACCATCGAGGTGTACGACC
CGGGCTCTGAGGACCCTCGGGGCACGGGCCCCTCTCAGGGGCCCGAGGACAATGGGGTCGGCGACGGCGAGGAAGCCAGCGGGGCGGATGGGGTCCCCATCGAGGCCGAGCCGCTGCCCTCCCTGGAGTACTGGCCCCAGAAGTCGGACC
GCTCCATCCCGCAGCTGGACCTGGGCTGGCCCGACACCATCGCCTACCGCGGCGTGACCCGGGCTAGCGTCTACATGCAGCCCCCCATAGACGGGCAGGCCCACATCAAAGAGGTGGTGCGGAAGATGATCAGCCAGGCACAGAAGGTGA
TAGCTGTGGTCATGGACATGTTCACCGACGTGGACATCTTCAAGGACCTGCTGGACGCCGGCTTCAAGAGGAAAGTGGCCGTGTACATCATCGTGGATGAGAGTAACGTCAAGTACTTCCTGCACATGTGTGAGCGGGCCTGCATGCACC
TGGGGCACCTCAAGTGGAAGAGAAAGCCAATACCCACCTCCTCTTGGGCATGTGCTTAGACGCCTGTGCTCGCTACCTTCTGTTCTCCAAGCAGCCGTCACAGGCACAAAGGATGTATGAAAAAGCTCTGCAGATTTCTGAAGAAATACA
AGGAGAAAGACACCCACAGACCATTGTGCTGATGAGTGACCTGGCTACTACCCTGGATGCACAGGGCCGCTTTGATGAGGCCTATATTTATATGCAAAGGGCATCAGATCTGGCAAGACAGATAAATCATCCTGAGCTACACATGGTACT
CAGTAATCTAGCTGCAGTTTTGATGCACAGAGAACGATATACACAAGCAAAAGAGATCTACCAGGAAGCACTGAAGCAAGCAAAGCTGAAAAAAGATGAAATTTCTGTACAACACATCAGGGAAGAGTTGGCTGAGCTGTCAAAGAAAAG
TAGACCTTTGACAAATTCTGTCAAGCTCTAAATCCATTTTTGTGTAGGGAGAATAATGTCTAGTAATGTGGAAGAATAGCTATCATTCCTGTCTCTGTGGCACCCGATCAATGGCTTAAATCTGTCGTTTTTGATATTCAGGTTTCCTCA
ATTTAGCCTTAGTGAAGGAGGGGTTGTACACACTGCCATTTTTGTATTTTAAAGGAAAAATGACTTTCATTCCCAACTGATTATGACCTTTCAGGATGTCGTCAAGTGATGCTTTCAGTTGTAACACGTGACTTGGTGCTGTCCCTGCTG
GTCTAAGTAGAACTGTAGATTCATATGGGCTGGTGTTCCTGTGCGCTGTGGGTGTGGTGATTCAGCCTGGCATTTCTACCATAAGTTTTTGGTCTGCTGATTTGCTGCCCTGTCTTCTCTTACTTTACTTTATCAATACCTGGCAAACTG
ACCAGAATTACCTTCCTCATGGCAAAGGGGGATTATGGTGAATTGTTGTTCTTATAGTCTGTTTCATGAAGCACAAGTGGAATTTAATACATAAAAGAGAAAAATATCTTAGTTTGCTACCAGCATCCAGCATGAAGTTGTAAAGTGGGG
ATTAGGCACGTGACAGTATAGCACCCATTTGAATTTAAATAAAAGTGAACCATATTTATCTGGTTATATAAAACTAAAAATGGGGGTGTTTATATAAAACTAAAAACTAAGAATGATGTAACCTTTTGTCTGTGTTATCTGAACACTCTA
CTTCCTTTGCAGCCTTAGTCACACAACTGAGTCATCTCAAGTACTCTTTAAGGACACACAGCCCAGGCTGTTCTGAGTCAGAATAGGCCCCTACAGGTATATTTTAAAACTCTTCGTAATTCTAATGTGTACTGCTGGTATAGCTGAACT
ACTGACCTGGATCTTAGTCCTAGCCTTTTTGCTTTTGCAATTTCAGTATCTTCATCTCTAAACTAGGGAAACACTGGGATTCTTTCTTAGCTGTGGGGGAAGGTATTTGGTTAGATGACTTTGAATGAATAGACTGCTGTGCTGAAAGAG
CTTTATCACACTGTCTCAAAGTATGTAAAGATACATAGGTGGATGCTCTTACTGCAGCAGTCATGAATACATTTTTAGCCATTTACCTAAGGAAAAAGACAGTTTTTCTAGGTACCATGAAGGAAGATTGACCCTGTTGGTATGCCTGTG
GGGGTGGGATGTGAGTGGGACTGATAAACTGATACTTTTGGTTCGTATGTACATACTGGAAGAATCTTCATAATAAATGAGACTACACAAC

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

>FAM83G_TTC19_ENST00000345041_ENST00000497842_18891559_15928330 length=856nt 
 Breakpoint=856nt
GCCCCCGCCGCCCCTCCCCGCGCGGCCCGCCCTCCCCGATTGCTCATGGGCAGAGAAGCAGAGGCCGCGGAGAGGCCCCCGAGCGCGCGGTGCCCCAGCTGGGCCGGAGCTAGGAGCTGGACCTTGCCCACCCACCCCCGGCAGCAGTGC
CCGGGCAGGCGGCGCCATGGCCTTCTCTCAGGTGCAGTGTCTGGACGACAACCATGTGAACTGGCGCTCCAGCGAGTCCAAGCCTGAGTTCTTCTACAGCGAGGAGCAGCGGCTGGCGCTGGAGGCCCTGGTGGCCCGCGGCCGGGACGC
CTTCTACGAGGTGCTCAAGCGGGAGAACATCCGAGACTTCCTCTCGGAGCTGGAGCTCAAGCGCATCCTGGAGACCATCGAGGTGTACGACCCGGGCTCTGAGGACCCTCGGGGCACGGGCCCCTCTCAGGGGCCCGAGGACAATGGGGT
CGGCGACGGCGAGGAAGCCAGCGGGGCGGATGGGGTCCCCATCGAGGCCGAGCCGCTGCCCTCCCTGGAGTACTGGCCCCAGAAGTCGGACCGCTCCATCCCGCAGCTGGACCTGGGCTGGCCCGACACCATCGCCTACCGCGGCGTGAC
CCGGGCTAGCGTCTACATGCAGCCCCCCATAGACGGGCAGGCCCACATCAAAGAGGTGGTGCGGAAGATGATCAGCCAGGCACAGAAGGTGATAGCTGTGGTCATGGACATGTTCACCGACGTGGACATCTTCAAGGACCTGCTGGACGC
CGGCTTCAAGAGGAAAGTGGCCGTGTACATCATCGTGGATGAGAGTAACGTCAAGTACTTCCTGCACATGTGTGAGCGGGCCTGCATGCACCTGGGGCACCTCAAG

>FAM83G_TTC19_ENST00000388995_ENST00000497842_18891559_15928330 length=914nt 
 Breakpoint=914nt
AGCGGGGCGGCCCTGAGTCACCGGCGCGCCCCCGCCCAGCCTCGCGCCGCCGCCGCAGCCGCCGCGTGTGCGCCCCGCTCCGCCAGCGCCCGCTCGATTGCTCATGGGCAGAGAAGCAGAGGCCGCGGAGAGGCCCCCGAGCGCGCGGTG
CCCCAGCTGGGCCGGAGCTAGGAGCTGGACCTTGCCCACCCACCCCCGGCAGCAGTGCCCGGGCAGGCGGCGCCATGGCCTTCTCTCAGGTGCAGTGTCTGGACGACAACCATGTGAACTGGCGCTCCAGCGAGTCCAAGCCTGAGTTCT
TCTACAGCGAGGAGCAGCGGCTGGCGCTGGAGGCCCTGGTGGCCCGCGGCCGGGACGCCTTCTACGAGGTGCTCAAGCGGGAGAACATCCGAGACTTCCTCTCGGAGCTGGAGCTCAAGCGCATCCTGGAGACCATCGAGGTGTACGACC
CGGGCTCTGAGGACCCTCGGGGCACGGGCCCCTCTCAGGGGCCCGAGGACAATGGGGTCGGCGACGGCGAGGAAGCCAGCGGGGCGGATGGGGTCCCCATCGAGGCCGAGCCGCTGCCCTCCCTGGAGTACTGGCCCCAGAAGTCGGACC
GCTCCATCCCGCAGCTGGACCTGGGCTGGCCCGACACCATCGCCTACCGCGGCGTGACCCGGGCTAGCGTCTACATGCAGCCCCCCATAGACGGGCAGGCCCACATCAAAGAGGTGGTGCGGAAGATGATCAGCCAGGCACAGAAGGTGA
TAGCTGTGGTCATGGACATGTTCACCGACGTGGACATCTTCAAGGACCTGCTGGACGCCGGCTTCAAGAGGAAAGTGGCCGTGTACATCATCGTGGATGAGAGTAACGTCAAGTACTTCCTGCACATGTGTGAGCGGGCCTGCATGCACC
TGGGGCACCTCAAG

>FAM83G_TTC19_ENST00000585154_ENST00000497842_18891559_15928330 length=825nt 
 Breakpoint=825nt
CCCGCAGATTGCTCATGGGCAGAGAAGCAGAGGCCGCGGAGAGGCCCCCGAGCGCGCGGTGCCCCAGCTGGGCCGGAGCTAGGAGCTGGACCTTGCCCACCCACCCCCGGCAGCAGTGCCCGGGCAGGCGGCGCCATGGCCTTCTCTCAG
GTGCAGTGTCTGGACGACAACCATGTGAACTGGCGCTCCAGCGAGTCCAAGCCTGAGTTCTTCTACAGCGAGGAGCAGCGGCTGGCGCTGGAGGCCCTGGTGGCCCGCGGCCGGGACGCCTTCTACGAGGTGCTCAAGCGGGAGAACATC
CGAGACTTCCTCTCGGAGCTGGAGCTCAAGCGCATCCTGGAGACCATCGAGGTGTACGACCCGGGCTCTGAGGACCCTCGGGGCACGGGCCCCTCTCAGGGGCCCGAGGACAATGGGGTCGGCGACGGCGAGGAAGCCAGCGGGGCGGAT
GGGGTCCCCATCGAGGCCGAGCCGCTGCCCTCCCTGGAGTACTGGCCCCAGAAGTCGGACCGCTCCATCCCGCAGCTGGACCTGGGCTGGCCCGACACCATCGCCTACCGCGGCGTGACCCGGGCTAGCGTCTACATGCAGCCCCCCATA
GACGGGCAGGCCCACATCAAAGAGGTGGTGCGGAAGATGATCAGCCAGGCACAGAAGGTGATAGCTGTGGTCATGGACATGTTCACCGACGTGGACATCTTCAAGGACCTGCTGGACGCCGGCTTCAAGAGGAAAGTGGCCGTGTACATC
ATCGTGGATGAGAGTAACGTCAAGTACTTCCTGCACATGTGTGAGCGGGCCTGCATGCACCTGGGGCACCTCAAG

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Fusion Protein Sequence for FAM83G_TTC19

In-frame Fusion Protein Sequences.

>FAM83G_TTC19_ENST00000388995_ENST00000261647_18891559_15928330 length=242nt
MHAPGAPQVGVHSVMKHDAIMDGASPDYVLVEAEANRVAQDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGKKSRFGKKRNSNFSVQHPSSTSPTEKCQDGIMKKEGKDNVPEHFSGRAEDADSSSGPLASSSLLAKMRARNHLIL
PERLESESGHLQEASALLPTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQSCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330 length=244nt
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for FAM83G_TTC19

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.D194H_244_D194H length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLHAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.E30K_244_E30K length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEKQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.E163K_244_E163K length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKKVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.R146W_244_R146W length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTWASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.Q88E_244_Q88E length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSEGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.V207M_244_V207M length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIMDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.V186M_244_V186M length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDMDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.P81T_244_P81T length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDTRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.K190N_244_K190N length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFNDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.D185G_244_D185G length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTGVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.S210I_244_S210I length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDEINVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.Q31R_244_Q31R length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEERRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.R166W_244_R166W length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVWKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.F25L_244_F25L length=244AA
MAFSQVQCLDDNHVNWRSSESKPELFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.G196S_244_G196S length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDASFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.H160Y_244_H160Y length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAYIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.D75N_244_D75N length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYNPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.Q5E_244_Q5E length=244AA
MAFSEVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.A37T_244_A37T length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALETLVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.V186A_244_V186A length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDADIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.R221W_244_R221W length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCEWACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.Q88E_244_Q88E length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSEGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.S60W_244_S60W length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLWELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.R52L_244_R52L length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKLENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.R43L_244_R43L length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGLDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.R52W_244_R52W length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKWENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.R126H_244_R126H length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDHSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.M224I_244_M224I length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACIHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.R43Q_244_R43Q length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGQDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.R82W_244_R82W length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPWGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.R221W_244_R221W length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCEWACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.E53D_244_E53D length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRDNIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.A104V_244_A104V length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGVDGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

>FAM83G_TTC19_ENST00000388995_ENST00000486880_18891559_15928330_5-gene_p.I161M_244_I161M length=244AA
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVY
MQPPIDGQAHMKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACA

Fusion Protein ID	Sample ID	Mutated Partner	AAchange in WT	Seq. Length	AAchange in Fusion
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-18-3411-01A	5-gene	p.D194H	244	D194H
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-44-6774-01A	5-gene	p.E30K	244	E30K
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-4Z-AA7W-01A	5-gene	p.E163K	244	E163K
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-67-3774-01A	5-gene	p.R146W	244	R146W
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-97-8176-01A	5-gene	p.Q88E	244	Q88E
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-A5-A0G1-01A	5-gene	p.V207M	244	V207M
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-A5-A0G2-01A	5-gene	p.V186M	244	V186M
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-AA-3877-01A	5-gene	p.P81T	244	P81T
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-AP-A0LM-01A	5-gene	p.K190N	244	K190N
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-AX-A06F-01A	5-gene	p.D185G	244	D185G
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-AX-A0J1-01A	5-gene	p.S210I	244	S210I
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-B0-5077-01A	5-gene	p.Q31R	244	Q31R
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-BG-A220-01A	5-gene	p.R166W	244	R166W
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-CG-5721-01A	5-gene	p.F25L	244	F25L
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-D1-A16Y-01A	5-gene	p.G196S	244	G196S
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-D3-A51J-06A	5-gene	p.H160Y	244	H160Y
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-D3-A8GI-06A	5-gene	p.D75N	244	D75N
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-D6-A74Q-01A	5-gene	p.Q5E	244	Q5E
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-DF-A2KU-01A	5-gene	p.A37T	244	A37T
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-DI-A1BU-01A	5-gene	p.V186A	244	V186A
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-DX-AB36-01A	5-gene	p.R221W	244	R221W
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-E5-A4U1-01A	5-gene	p.Q88E	244	Q88E
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-E7-A7XN-01A	5-gene	p.S60W	244	S60W
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-EE-A3AA-06A	5-gene	p.R52L	244	R52L
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-EE-A3AH-06A	5-gene	p.R43L	244	R43L
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-EO-A22U-01A	5-gene	p.R52W	244	R52W
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-EY-A215-01A	5-gene	p.R126H	244	R126H
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-FI-A2D5-01A	5-gene	p.M224I	244	M224I
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-FR-A726-01A	5-gene	p.R43Q	244	R43Q
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-IG-A5B8-01A	5-gene	p.R82W	244	R82W
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-L5-A4OI-01A	5-gene	p.R221W	244	R221W
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-UY-A8OB-01A	5-gene	p.E53D	244	E53D
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-VQ-A91D-01A	5-gene	p.A104V	244	A104V
ENST00000388995_ENST00000486880_18891559_15928330	TCGA-VS-A8Q8-01A	5-gene	p.I161M	244	I161M

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for FAM83G_TTC19

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		BRCA	TCGA-D8-A1JA-01A	FAM83G	chr17	18891559	-	TTC19	chr17	18891559	+
TCGAfusionPortal		BRCA	TCGA-D8-A1JA-01A	FAM83G	chr17	18891560	-	TTC19	chr17	15928331	+
cBioPortal	BRCA_TCGA_PAN_CAN_ATLAS_2018	BRCA	TCGA-D8-A1JA-01	FAM83G	chr17	18988247		TTC19	chr17	16025017

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for FAM83G_TTC19

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status