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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:RBM12_LPO (FusionGDB2 ID:HG10137TG4025)

Fusion Gene Summary for RBM12_LPO

Fusion gene summary

Fusion gene information	Fusion gene name: RBM12_LPO
	Fusion gene ID: hg10137tg4025
		Hgene	Tgene
	Gene symbol	RBM12	LPO
	Gene ID	10137	4025
	Gene name	RNA binding motif protein 12	lactoperoxidase
	Synonyms	HRIHFB2091\|SCZD19\|SWAN	SPO
	Cytomap	20q11.22	17q22
	Type of gene	protein-coding	protein-coding
	Description	RNA-binding protein 12SH3/WW domain anchor protein in the nucleus	lactoperoxidasesalivary peroxidase
	Modification date	20240305	20240403
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000359646, ENST00000374104, ENST00000374114,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 11 X 14 X 9=1386	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 3 X 12 X 3=108
	# samples	528	8
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(528/138610)=1.9296106721086 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(8/10810)=-0.432959407276106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RBM12 [Title/Abstract] AND LPO [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RBM12(34252681)-LPO(56344709), # samples:1

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Fusion Gene Breakpoints for RBM12_LPO

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
RBM12	chr20	34252681	LPO	chr17	34252681
RBM12	chr20	34252682	LPO	chr17	56344710
RBM12	chr20	35664760	LPO	chr17	58267349

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for RBM12_LPO

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	LPO	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste	24248522
Tgene	LPO	GO:0042742	defense response to bacterium	12626341

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Fusion Genomic Features for RBM12_LPO

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
RBM12	chr20	34252681	-	LPO	chr17	56344709	+	1.52e-08	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
RBM12	chr20	34252681	-	LPO	chr17	56344709	+	1.52e-08	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for RBM12_LPO

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000359646	ENST00000262290	RBM12	chr20	34252681	-	LPO	chr17	56344709	+
5UTR-3CDS	ENST00000359646	ENST00000421678	RBM12	chr20	34252681	-	LPO	chr17	56344709	+
5UTR-3CDS	ENST00000359646	ENST00000543544	RBM12	chr20	34252681	-	LPO	chr17	56344709	+
5UTR-3CDS	ENST00000359646	ENST00000582328	RBM12	chr20	34252681	-	LPO	chr17	56344709	+
5UTR-3CDS	ENST00000374104	ENST00000262290	RBM12	chr20	34252681	-	LPO	chr17	56344709	+
5UTR-3CDS	ENST00000374104	ENST00000421678	RBM12	chr20	34252681	-	LPO	chr17	56344709	+
5UTR-3CDS	ENST00000374104	ENST00000543544	RBM12	chr20	34252681	-	LPO	chr17	56344709	+
5UTR-3CDS	ENST00000374104	ENST00000582328	RBM12	chr20	34252681	-	LPO	chr17	56344709	+
5UTR-3CDS	ENST00000374114	ENST00000262290	RBM12	chr20	34252681	-	LPO	chr17	56344709	+
5UTR-3CDS	ENST00000374114	ENST00000421678	RBM12	chr20	34252681	-	LPO	chr17	56344709	+
5UTR-3CDS	ENST00000374114	ENST00000543544	RBM12	chr20	34252681	-	LPO	chr17	56344709	+
5UTR-3CDS	ENST00000374114	ENST00000582328	RBM12	chr20	34252681	-	LPO	chr17	56344709	+

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000359646	ENST00000262290	RBM12	chr20	34252681	LPO	chr17	56344709	0	631
ENST00000359646	ENST00000421678	RBM12	chr20	34252681	LPO	chr17	56344709	0	682
ENST00000359646	ENST00000543544	RBM12	chr20	34252681	LPO	chr17	56344709	0	586
ENST00000359646	ENST00000582328	RBM12	chr20	34252681	LPO	chr17	56344709	0	129
ENST00000374104	ENST00000262290	RBM12	chr20	34252681	LPO	chr17	56344709	0	81
ENST00000374104	ENST00000421678	RBM12	chr20	34252681	LPO	chr17	56344709	0	682
ENST00000374104	ENST00000543544	RBM12	chr20	34252681	LPO	chr17	56344709	0	586
ENST00000374104	ENST00000582328	RBM12	chr20	34252681	LPO	chr17	56344709	0	129
ENST00000374114	ENST00000262290	RBM12	chr20	34252681	LPO	chr17	56344709	0	81
ENST00000374114	ENST00000421678	RBM12	chr20	34252681	LPO	chr17	56344709	0	682
ENST00000374114	ENST00000543544	RBM12	chr20	34252681	LPO	chr17	56344709	0	586
ENST00000374114	ENST00000582328	RBM12	chr20	34252681	LPO	chr17	56344709	0	129

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000359646	ENST00000262290	RBM12	chr20	34252681	LPO	chr17	56344709	0.00e+00	8.72e-02
ENST00000359646	ENST00000421678	RBM12	chr20	34252681	LPO	chr17	56344709	0.00e+00	8.85e-02
ENST00000359646	ENST00000543544	RBM12	chr20	34252681	LPO	chr17	56344709	0.00e+00	6.21e-03
ENST00000359646	ENST00000582328	RBM12	chr20	34252681	LPO	chr17	56344709	0.00e+00	8.71e-03
ENST00000374104	ENST00000262290	RBM12	chr20	34252681	LPO	chr17	56344709	0.00e+00	8.72e-02
ENST00000374104	ENST00000421678	RBM12	chr20	34252681	LPO	chr17	56344709	0.00e+00	8.85e-02
ENST00000374104	ENST00000543544	RBM12	chr20	34252681	LPO	chr17	56344709	0.00e+00	6.21e-03
ENST00000374104	ENST00000582328	RBM12	chr20	34252681	LPO	chr17	56344709	0.00e+00	8.71e-03
ENST00000374114	ENST00000262290	RBM12	chr20	34252681	LPO	chr17	56344709	0.00e+00	8.72e-02
ENST00000374114	ENST00000421678	RBM12	chr20	34252681	LPO	chr17	56344709	0.00e+00	8.85e-02
ENST00000374114	ENST00000543544	RBM12	chr20	34252681	LPO	chr17	56344709	0.00e+00	6.21e-03
ENST00000374114	ENST00000582328	RBM12	chr20	34252681	LPO	chr17	56344709	0.00e+00	8.71e-03

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for RBM12_LPO

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for RBM12_LPO

In-frame Fusion Transcript Sequences.

N-Truncated Transcript (5UTR-3CDS) Sequences

>RBM12_LPO_ENST00000359646_ENST00000262290_34252681_56344709 length=970nt 
 Breakpoint=0nt
GGTACAATTCCTGGAGAGCCTTCTGTGACCTCTCACAGCCGCAGACACTAGAGGAGTTGAACACAGTGCTGAAGAGCAAGATGCTGGCCAAGAAGTTACTGGGTCTCTACGGGACCCCTGACAACATCGACATCTGGATAGGGGCCATTG
CTGAGCCGCTGGTGGAAAGGGGTCGGGTGGGGCCTCTCCTGGCCTGCCTCTTGGGCAAGCAGTTCCAGCAGATCCGTGATGGAGACAGGTTCTGGTGGGAAAACCCTGGGGTCTTCACGAACGAGCAGAAGGACTCTCTACAGAAAATGT
CCTTCTCACGCCTTGTCTGTGACAACACCCGCATCACCAAGGTCCCACGGGACCCATTCTGGGCCAACAGCTACCCCTATGACTTCGTGGATTGCTCAGCCATCGACAAGCTGGACCTGTCACCCTGGGCCTCAGTGAAGAATTAGGGGC
CCGCGCTGCACAGGAAAGTTCCCTTTGGTCCACAGGGCCATTTCAAGCAAGTTCAATGACCTGGTCCCTTAGAGCTCCATATCCCAGTCCCAGCCCTTCTTTGCAGCTGGGCCTCTCTATACCCCTGGATGAACAGCTTGCTCAGGCCCC
AGGGTGGCTGCCTCGGCCCTCCCAGCTCTTACACTCAGCTCCAGTGGCTTCTCCTTTCTGTCAAGACTTAGCCCCGCTGAGATGCCCTTCTGCTCCAGCTTGCTGGATGTTACCTGTCCTCTTCCCTCCACAAGTCTTGGCCCTTAACCT
TTATCTTTCTTCCTGTCCTCTCACCTAGATTGTAAGCTCCCTGGGCCAGGACTTCAGCCTGCCTCCGAGGGTCCCCTGTGGCACCTAGCATGGTGCACAGCACATTAGAAGTGCTCAAAAACATCTGATGACTGACTAAAGATGCTAGGC
GTGACACCGTTCCCTCCAAAAGCAGACCTCGGAATCACTGCCAAATAAGTAACTAGACGTTTACAGGCCA

>RBM12_LPO_ENST00000359646_ENST00000421678_34252681_56344709 length=969nt 
 Breakpoint=0nt
GGTACAATTCCTGGAGAGCCTTCTGTGACCTCTCACAGCCGCAGACACTAGAGGAGTTGAACACAGTGCTGAAGAGCAAGATGCTGGCCAAGAAGTTACTGGGTCTCTACGGGACCCCTGACAACATCGACATCTGGATAGGGGCCATTG
CTGAGCCGCTGGTGGAAAGGGGTCGGGTGGGGCCTCTCCTGGCCTGCCTCTTGGGCAAGCAGTTCCAGCAGATCCGTGATGGAGACAGGTTCTGGTGGGAAAACCCTGGGGTCTTCACGAACGAGCAGAAGGACTCTCTACAGAAAATGT
CCTTCTCACGCCTTGTCTGTGACAACACCCGCATCACCAAGGTCCCACGGGACCCATTCTGGGCCAACAGCTACCCCTATGACTTCGTGGATTGCTCAGCCATCGACAAGCTGGACCTGTCACCCTGGGCCTCAGTGAAGAATTAGGGGC
CCGCGCTGCACAGGAAAGTTCCCTTTGGTCCACAGGGCCATTTCAAGCAAGTTCAATGACCTGGTCCCTTAGAGCTCCATATCCCAGTCCCAGCCCTTCTTTGCAGCTGGGCCTCTCTATACCCCTGGATGAACAGCTTGCTCAGGCCCC
AGGGTGGCTGCCTCGGCCCTCCCAGCTCTTACACTCAGCTCCAGTGGCTTCTCCTTTCTGTCAAGACTTAGCCCCGCTGAGATGCCCTTCTGCTCCAGCTTGCTGGATGTTACCTGTCCTCTTCCCTCCACAAGTCTTGGCCCTTAACCT
TTATCTTTCTTCCTGTCCTCTCACCTAGATTGTAAGCTCCCTGGGCCAGGACTTCAGCCTGCCTCCGAGGGTCCCCTGTGGCACCTAGCATGGTGCACAGCACATTAGAAGTGCTCAAAAACATCTGATGACTGACTAAAGATGCTAGGC
GTGACACCGTTCCCTCCAAAAGCAGACCTCGGAATCACTGCCAAATAAGTAACTAGACGTTTACAGGCC

>RBM12_LPO_ENST00000359646_ENST00000543544_34252681_56344709 length=594nt 
 Breakpoint=0nt
GGTACAATTCCTGGAGAGCCTTCTGTGACCTCTCACAGCCGCAGACACTAGAGGAGTTGAACACAGTGCTGAAGAGCAAGATGCTGGCCAAGAAGTTACTGGGTCTCTACGGGACCCCTGACAACATCGACATCTGGATAGGGGCCATTG
CTGAGCCGCTGGTGGAAAGGGGTCGGGTGGGGCCTCTCCTGGCCTGCCTCTTGGGCAAGCAGTTCCAGCAGATCCGTGATGGAGACAGGTTCTGGTGGGAAAACCCTGGGGTCTTCACGAACGAGCAGAAGGACTCTCTACAGAAAATGT
CCTTCTCACGCCTTGTCTGTGACAACACCCGCATCACCAAGGTCCCACGGGACCCATTCTGGGCCAACAGCTACCCCTATGACTTCGTGGATTGCTCAGCCATCGACAAGCTGGACCTGTCACCCTGGGCCTCAGTGAAGAATTAGGGGC
CCGCGCTGCACAGGAAAGTTCCCTTTGGTCCACAGGGCCATTTCAAGCAAGTTCAATGACCTGGTCCCTTAGAGCTCCATATCCCAGTCCCAGCCCTTCTTTGCAGCTGGGCCTCTCTATACCCCTGGATGAACAGCTTGCTCA

>RBM12_LPO_ENST00000359646_ENST00000582328_34252681_56344709 length=678nt 
 Breakpoint=0nt
GGTACAATTCCTGGAGAGCCTTCTGTGACCTCTCACAGCCGCAGACACTAGAGGAGTTGAACACAGTGCTGAAGAGCAAGATGCTGGCCAAGAAGTTACTGGGTCTCTACGGGACCCCTGACAACATCGACATCTGGATAGGGGCCATTG
CTGAGCCGCTGGTGGAAAGGGGTCGGGTGGGGCCTCTCCTGGCCTGCCTCTTGGGCAAGCAGTTCCAGCAGATCCGTGATGGAGACAGGTTCTGGTGGGAAAACCCTGGGGTCTTCACGAACGAGCAGAAGGACTCTCTACAGAAAATGT
CCTTCTCACGCCTTGTCTGTGACAACACCCGCATCACCAAGGTCCCACGGGACCCATTCTGGGCCAACAGCTACCCCTATGACTTCGTGGATTGCTCAGCCATCGACAAGCTGGACCTGTCACCCTGGGCCTCAGTGAAGAATTAGGGGC
CCGCGCTGCACAGGAAAGTTCCCTTTGGTCCACAGGGCCATTTCAAGCAAGTTCAATGACCTGGTCCCTTAGAGCTCCATATCCCAGTCCCAGCCCTTCTTTGCAGCTGGGCCTCTCTATACCCCTGGATGAACAGCTTGCTCAGGCCCC
AGGGTGGCTGCCTCGGCCCTCCCAGCTCTTACACTCAGCTCCAGTGGCTTCTCCTTTCTGTCAAGACTTAGCCCCGCT

>RBM12_LPO_ENST00000374104_ENST00000262290_34252681_56344709 length=970nt 
 Breakpoint=0nt
GGTACAATTCCTGGAGAGCCTTCTGTGACCTCTCACAGCCGCAGACACTAGAGGAGTTGAACACAGTGCTGAAGAGCAAGATGCTGGCCAAGAAGTTACTGGGTCTCTACGGGACCCCTGACAACATCGACATCTGGATAGGGGCCATTG
CTGAGCCGCTGGTGGAAAGGGGTCGGGTGGGGCCTCTCCTGGCCTGCCTCTTGGGCAAGCAGTTCCAGCAGATCCGTGATGGAGACAGGTTCTGGTGGGAAAACCCTGGGGTCTTCACGAACGAGCAGAAGGACTCTCTACAGAAAATGT
CCTTCTCACGCCTTGTCTGTGACAACACCCGCATCACCAAGGTCCCACGGGACCCATTCTGGGCCAACAGCTACCCCTATGACTTCGTGGATTGCTCAGCCATCGACAAGCTGGACCTGTCACCCTGGGCCTCAGTGAAGAATTAGGGGC
CCGCGCTGCACAGGAAAGTTCCCTTTGGTCCACAGGGCCATTTCAAGCAAGTTCAATGACCTGGTCCCTTAGAGCTCCATATCCCAGTCCCAGCCCTTCTTTGCAGCTGGGCCTCTCTATACCCCTGGATGAACAGCTTGCTCAGGCCCC
AGGGTGGCTGCCTCGGCCCTCCCAGCTCTTACACTCAGCTCCAGTGGCTTCTCCTTTCTGTCAAGACTTAGCCCCGCTGAGATGCCCTTCTGCTCCAGCTTGCTGGATGTTACCTGTCCTCTTCCCTCCACAAGTCTTGGCCCTTAACCT
TTATCTTTCTTCCTGTCCTCTCACCTAGATTGTAAGCTCCCTGGGCCAGGACTTCAGCCTGCCTCCGAGGGTCCCCTGTGGCACCTAGCATGGTGCACAGCACATTAGAAGTGCTCAAAAACATCTGATGACTGACTAAAGATGCTAGGC
GTGACACCGTTCCCTCCAAAAGCAGACCTCGGAATCACTGCCAAATAAGTAACTAGACGTTTACAGGCCA

>RBM12_LPO_ENST00000374104_ENST00000421678_34252681_56344709 length=969nt 
 Breakpoint=0nt
GGTACAATTCCTGGAGAGCCTTCTGTGACCTCTCACAGCCGCAGACACTAGAGGAGTTGAACACAGTGCTGAAGAGCAAGATGCTGGCCAAGAAGTTACTGGGTCTCTACGGGACCCCTGACAACATCGACATCTGGATAGGGGCCATTG
CTGAGCCGCTGGTGGAAAGGGGTCGGGTGGGGCCTCTCCTGGCCTGCCTCTTGGGCAAGCAGTTCCAGCAGATCCGTGATGGAGACAGGTTCTGGTGGGAAAACCCTGGGGTCTTCACGAACGAGCAGAAGGACTCTCTACAGAAAATGT
CCTTCTCACGCCTTGTCTGTGACAACACCCGCATCACCAAGGTCCCACGGGACCCATTCTGGGCCAACAGCTACCCCTATGACTTCGTGGATTGCTCAGCCATCGACAAGCTGGACCTGTCACCCTGGGCCTCAGTGAAGAATTAGGGGC
CCGCGCTGCACAGGAAAGTTCCCTTTGGTCCACAGGGCCATTTCAAGCAAGTTCAATGACCTGGTCCCTTAGAGCTCCATATCCCAGTCCCAGCCCTTCTTTGCAGCTGGGCCTCTCTATACCCCTGGATGAACAGCTTGCTCAGGCCCC
AGGGTGGCTGCCTCGGCCCTCCCAGCTCTTACACTCAGCTCCAGTGGCTTCTCCTTTCTGTCAAGACTTAGCCCCGCTGAGATGCCCTTCTGCTCCAGCTTGCTGGATGTTACCTGTCCTCTTCCCTCCACAAGTCTTGGCCCTTAACCT
TTATCTTTCTTCCTGTCCTCTCACCTAGATTGTAAGCTCCCTGGGCCAGGACTTCAGCCTGCCTCCGAGGGTCCCCTGTGGCACCTAGCATGGTGCACAGCACATTAGAAGTGCTCAAAAACATCTGATGACTGACTAAAGATGCTAGGC
GTGACACCGTTCCCTCCAAAAGCAGACCTCGGAATCACTGCCAAATAAGTAACTAGACGTTTACAGGCC

>RBM12_LPO_ENST00000374104_ENST00000543544_34252681_56344709 length=594nt 
 Breakpoint=0nt
GGTACAATTCCTGGAGAGCCTTCTGTGACCTCTCACAGCCGCAGACACTAGAGGAGTTGAACACAGTGCTGAAGAGCAAGATGCTGGCCAAGAAGTTACTGGGTCTCTACGGGACCCCTGACAACATCGACATCTGGATAGGGGCCATTG
CTGAGCCGCTGGTGGAAAGGGGTCGGGTGGGGCCTCTCCTGGCCTGCCTCTTGGGCAAGCAGTTCCAGCAGATCCGTGATGGAGACAGGTTCTGGTGGGAAAACCCTGGGGTCTTCACGAACGAGCAGAAGGACTCTCTACAGAAAATGT
CCTTCTCACGCCTTGTCTGTGACAACACCCGCATCACCAAGGTCCCACGGGACCCATTCTGGGCCAACAGCTACCCCTATGACTTCGTGGATTGCTCAGCCATCGACAAGCTGGACCTGTCACCCTGGGCCTCAGTGAAGAATTAGGGGC
CCGCGCTGCACAGGAAAGTTCCCTTTGGTCCACAGGGCCATTTCAAGCAAGTTCAATGACCTGGTCCCTTAGAGCTCCATATCCCAGTCCCAGCCCTTCTTTGCAGCTGGGCCTCTCTATACCCCTGGATGAACAGCTTGCTCA

>RBM12_LPO_ENST00000374104_ENST00000582328_34252681_56344709 length=678nt 
 Breakpoint=0nt
GGTACAATTCCTGGAGAGCCTTCTGTGACCTCTCACAGCCGCAGACACTAGAGGAGTTGAACACAGTGCTGAAGAGCAAGATGCTGGCCAAGAAGTTACTGGGTCTCTACGGGACCCCTGACAACATCGACATCTGGATAGGGGCCATTG
CTGAGCCGCTGGTGGAAAGGGGTCGGGTGGGGCCTCTCCTGGCCTGCCTCTTGGGCAAGCAGTTCCAGCAGATCCGTGATGGAGACAGGTTCTGGTGGGAAAACCCTGGGGTCTTCACGAACGAGCAGAAGGACTCTCTACAGAAAATGT
CCTTCTCACGCCTTGTCTGTGACAACACCCGCATCACCAAGGTCCCACGGGACCCATTCTGGGCCAACAGCTACCCCTATGACTTCGTGGATTGCTCAGCCATCGACAAGCTGGACCTGTCACCCTGGGCCTCAGTGAAGAATTAGGGGC
CCGCGCTGCACAGGAAAGTTCCCTTTGGTCCACAGGGCCATTTCAAGCAAGTTCAATGACCTGGTCCCTTAGAGCTCCATATCCCAGTCCCAGCCCTTCTTTGCAGCTGGGCCTCTCTATACCCCTGGATGAACAGCTTGCTCAGGCCCC
AGGGTGGCTGCCTCGGCCCTCCCAGCTCTTACACTCAGCTCCAGTGGCTTCTCCTTTCTGTCAAGACTTAGCCCCGCT

>RBM12_LPO_ENST00000374114_ENST00000262290_34252681_56344709 length=970nt 
 Breakpoint=0nt
GGTACAATTCCTGGAGAGCCTTCTGTGACCTCTCACAGCCGCAGACACTAGAGGAGTTGAACACAGTGCTGAAGAGCAAGATGCTGGCCAAGAAGTTACTGGGTCTCTACGGGACCCCTGACAACATCGACATCTGGATAGGGGCCATTG
CTGAGCCGCTGGTGGAAAGGGGTCGGGTGGGGCCTCTCCTGGCCTGCCTCTTGGGCAAGCAGTTCCAGCAGATCCGTGATGGAGACAGGTTCTGGTGGGAAAACCCTGGGGTCTTCACGAACGAGCAGAAGGACTCTCTACAGAAAATGT
CCTTCTCACGCCTTGTCTGTGACAACACCCGCATCACCAAGGTCCCACGGGACCCATTCTGGGCCAACAGCTACCCCTATGACTTCGTGGATTGCTCAGCCATCGACAAGCTGGACCTGTCACCCTGGGCCTCAGTGAAGAATTAGGGGC
CCGCGCTGCACAGGAAAGTTCCCTTTGGTCCACAGGGCCATTTCAAGCAAGTTCAATGACCTGGTCCCTTAGAGCTCCATATCCCAGTCCCAGCCCTTCTTTGCAGCTGGGCCTCTCTATACCCCTGGATGAACAGCTTGCTCAGGCCCC
AGGGTGGCTGCCTCGGCCCTCCCAGCTCTTACACTCAGCTCCAGTGGCTTCTCCTTTCTGTCAAGACTTAGCCCCGCTGAGATGCCCTTCTGCTCCAGCTTGCTGGATGTTACCTGTCCTCTTCCCTCCACAAGTCTTGGCCCTTAACCT
TTATCTTTCTTCCTGTCCTCTCACCTAGATTGTAAGCTCCCTGGGCCAGGACTTCAGCCTGCCTCCGAGGGTCCCCTGTGGCACCTAGCATGGTGCACAGCACATTAGAAGTGCTCAAAAACATCTGATGACTGACTAAAGATGCTAGGC
GTGACACCGTTCCCTCCAAAAGCAGACCTCGGAATCACTGCCAAATAAGTAACTAGACGTTTACAGGCCA

>RBM12_LPO_ENST00000374114_ENST00000421678_34252681_56344709 length=969nt 
 Breakpoint=0nt
GGTACAATTCCTGGAGAGCCTTCTGTGACCTCTCACAGCCGCAGACACTAGAGGAGTTGAACACAGTGCTGAAGAGCAAGATGCTGGCCAAGAAGTTACTGGGTCTCTACGGGACCCCTGACAACATCGACATCTGGATAGGGGCCATTG
CTGAGCCGCTGGTGGAAAGGGGTCGGGTGGGGCCTCTCCTGGCCTGCCTCTTGGGCAAGCAGTTCCAGCAGATCCGTGATGGAGACAGGTTCTGGTGGGAAAACCCTGGGGTCTTCACGAACGAGCAGAAGGACTCTCTACAGAAAATGT
CCTTCTCACGCCTTGTCTGTGACAACACCCGCATCACCAAGGTCCCACGGGACCCATTCTGGGCCAACAGCTACCCCTATGACTTCGTGGATTGCTCAGCCATCGACAAGCTGGACCTGTCACCCTGGGCCTCAGTGAAGAATTAGGGGC
CCGCGCTGCACAGGAAAGTTCCCTTTGGTCCACAGGGCCATTTCAAGCAAGTTCAATGACCTGGTCCCTTAGAGCTCCATATCCCAGTCCCAGCCCTTCTTTGCAGCTGGGCCTCTCTATACCCCTGGATGAACAGCTTGCTCAGGCCCC
AGGGTGGCTGCCTCGGCCCTCCCAGCTCTTACACTCAGCTCCAGTGGCTTCTCCTTTCTGTCAAGACTTAGCCCCGCTGAGATGCCCTTCTGCTCCAGCTTGCTGGATGTTACCTGTCCTCTTCCCTCCACAAGTCTTGGCCCTTAACCT
TTATCTTTCTTCCTGTCCTCTCACCTAGATTGTAAGCTCCCTGGGCCAGGACTTCAGCCTGCCTCCGAGGGTCCCCTGTGGCACCTAGCATGGTGCACAGCACATTAGAAGTGCTCAAAAACATCTGATGACTGACTAAAGATGCTAGGC
GTGACACCGTTCCCTCCAAAAGCAGACCTCGGAATCACTGCCAAATAAGTAACTAGACGTTTACAGGCC

>RBM12_LPO_ENST00000374114_ENST00000543544_34252681_56344709 length=594nt 
 Breakpoint=0nt
GGTACAATTCCTGGAGAGCCTTCTGTGACCTCTCACAGCCGCAGACACTAGAGGAGTTGAACACAGTGCTGAAGAGCAAGATGCTGGCCAAGAAGTTACTGGGTCTCTACGGGACCCCTGACAACATCGACATCTGGATAGGGGCCATTG
CTGAGCCGCTGGTGGAAAGGGGTCGGGTGGGGCCTCTCCTGGCCTGCCTCTTGGGCAAGCAGTTCCAGCAGATCCGTGATGGAGACAGGTTCTGGTGGGAAAACCCTGGGGTCTTCACGAACGAGCAGAAGGACTCTCTACAGAAAATGT
CCTTCTCACGCCTTGTCTGTGACAACACCCGCATCACCAAGGTCCCACGGGACCCATTCTGGGCCAACAGCTACCCCTATGACTTCGTGGATTGCTCAGCCATCGACAAGCTGGACCTGTCACCCTGGGCCTCAGTGAAGAATTAGGGGC
CCGCGCTGCACAGGAAAGTTCCCTTTGGTCCACAGGGCCATTTCAAGCAAGTTCAATGACCTGGTCCCTTAGAGCTCCATATCCCAGTCCCAGCCCTTCTTTGCAGCTGGGCCTCTCTATACCCCTGGATGAACAGCTTGCTCA

>RBM12_LPO_ENST00000374114_ENST00000582328_34252681_56344709 length=678nt 
 Breakpoint=0nt
GGTACAATTCCTGGAGAGCCTTCTGTGACCTCTCACAGCCGCAGACACTAGAGGAGTTGAACACAGTGCTGAAGAGCAAGATGCTGGCCAAGAAGTTACTGGGTCTCTACGGGACCCCTGACAACATCGACATCTGGATAGGGGCCATTG
CTGAGCCGCTGGTGGAAAGGGGTCGGGTGGGGCCTCTCCTGGCCTGCCTCTTGGGCAAGCAGTTCCAGCAGATCCGTGATGGAGACAGGTTCTGGTGGGAAAACCCTGGGGTCTTCACGAACGAGCAGAAGGACTCTCTACAGAAAATGT
CCTTCTCACGCCTTGTCTGTGACAACACCCGCATCACCAAGGTCCCACGGGACCCATTCTGGGCCAACAGCTACCCCTATGACTTCGTGGATTGCTCAGCCATCGACAAGCTGGACCTGTCACCCTGGGCCTCAGTGAAGAATTAGGGGC
CCGCGCTGCACAGGAAAGTTCCCTTTGGTCCACAGGGCCATTTCAAGCAAGTTCAATGACCTGGTCCCTTAGAGCTCCATATCCCAGTCCCAGCCCTTCTTTGCAGCTGGGCCTCTCTATACCCCTGGATGAACAGCTTGCTCAGGCCCC
AGGGTGGCTGCCTCGGCCCTCCCAGCTCTTACACTCAGCTCCAGTGGCTTCTCCTTTCTGTCAAGACTTAGCCCCGCT

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for RBM12_LPO

In-frame Fusion Protein Sequences.

N-Truncated Protein (5UTR-3CDS) Sequences

>RBM12_LPO_ENST00000359646_ENST00000262290_34252681_56344709 length=631nt
MRFQRLGHLVALMALLCGDPQEKVAEEAAEGIHSLLHITLRLKYITHDKKDQQNLKRALTKCREFLELHSSAAKCFYNCPFRIAQVPEIMGVICAQLSIISQPRVRQQIINTVSLFISRPKYTDIVLSFLLCHPVPYNRHLAEVWRMLSV
ELPSTTWILWRLLRKLQKCHNEPAQEKMAYVAVAATDALYEVFLGNRLRAATFRLFPQLLMTLLIQIHHSIGLTMSDVDIPSGLYTEQEVPSEVTPLCFAMQATKTLLLRTCCLQEFNIMEKNKGWALLGGKDGHLQGLFLLANALLERN
QLLAQKVMYLLVPLLNRGNDKHKLTSAGFFVELLRSPVAKRLPSIYSVARFKDWLQDGNHLFRILGLRGLYNLVGHQEMREDIKSLLPYIVDSLRETDEKIVLSAIQILLQLVRTMDFTTLAAMMRTLFSLFGDVRSDVHRFSVTLFGAA
IKSVKNPDKKSIENQVLDSLVPLLLYSQDENDAVAEESRQVLTICAQFLKWKLPQEVYSKDPWHIKPTEAGTICRFFEKKCKGKINILEQTLMYSKNPKLPIRRSAVLFVGLLSKYMDHNELRRMGTDWIEDDLRDLLCDPEPSLCIIAS
QTLLLVQMARAEPKPKQRVNWLQKLMGRSSA

>RBM12_LPO_ENST00000359646_ENST00000421678_34252681_56344709 length=682nt
MRFQRLGHLVALMALLCGDPQEKVAEEAAEGIHSLLHITLRLKYITHDKKDQQNLKRALTKCREFLELHSSAAKCFYNCPFRIAQVFEGFLDSNELCQFIMTTFDTLKTLKHPCIQRSAGELLLTLAKNTESQFEKVPEIMGVICAQLSI
ISQPRVRQQIINTVSLFISRPKYTDIVLSFLLCHPVPYNRHLAEVWRMLSVELPSTTWILWRLLRKLQKCHNEPAQEKMAYVAVAATDALYEVFLGNRLRAATFRLFPQLLMTLLIQIHHSIGLTMSDVDIPSGLYTEQEVPSEVTPLCF
AMQATKTLLLRTCCLQEFNIMEKNKGWALLGGKDGHLQGLFLLANALLERNQLLAQKVMYLLVPLLNRGNDKHKLTSAGFFVELLRSPVAKRLPSIYSVARFKDWLQDGNHLFRILGLRGLYNLVGHQEMREDIKSLLPYIVDSLRETDE
KIVLSAIQILLQLVRTMDFTTLAAMMRTLFSLFGDVRSDVHRFSVTLFGAAIKSVKNPDKKSIENQVLDSLVPLLLYSQDENDAVAEESRQVLTICAQFLKWKLPQEVYSKDPWHIKPTEAGTICRFFEKKCKGKINILEQTLMYSKNPK
LPIRRSAVLFVGLLSKYMDHNELRRMGTDWIEDDLRDLLCDPEPSLCIIASQTLLLVQMARAEPKPKQRVNWLQKLMGRSSA

>RBM12_LPO_ENST00000359646_ENST00000543544_34252681_56344709 length=586nt
MRFQRLGHLVALMALLCGDPQEKVAEEAAEGIHSLLHITLRLKYITHDKKDQQNLKRALTKCREFLELHSSAAKCFYNCPFRIAQVFEGFLDSNELCQFIMTTFDTLKTLKHPCIQRSAGELLLTLAKNTESQFEKVPEIMGVICAQLSI
ISQPRVRQQIINTVSLFISRPKYTDIVLSFLLCHPVPYNRHLAEVWRMLSVELPSTTWILWRLLRKLQKCHNEPAQEKMAYVAVAATDALYEVFLGNRLRAATFRLFPQLLMTLLIQIHHSIGLTMSDVDIPSGLYTEQEVPSEVTPLCF
AMQATKTLLLRTCCLQEFNIMEKNKGWALLGGKDGHLQGLFLLANALLERNQLLAQKVMYLLVPLLNRGNDKHKLTSAGFFVELLRSPVAKRLPSIYSVARFKDWLQDGNHLFRILGLRGLYNLVGHQEMREDIKSLLPYIVDSLRETDE
KIVLSAIQILLQLVRTMDFTTLAAMMRTLFSLFGDVRSDVHRFSVTLFGAAIKSVKNPDKKSIENQVLDSLVPLLLYSQDENDAVAEESRQVLTICAQFLKWKLPQEVYSKDPWHIKPTEAGTICRFFGKKVQGEN

>RBM12_LPO_ENST00000359646_ENST00000582328_34252681_56344709 length=129nt
MNTVLKSKMLAKKLLGLYGTPDNIDIWIGAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWWENPGVFTNEQKDSLQKMSFSRLVCDNTRITKVPRDPFWANSYPYDFVDCSAIDKLDLSPWASVKN

>RBM12_LPO_ENST00000374104_ENST00000262290_34252681_56344709 length=81nt
MTAQESRSAVKALAGWPVSFPSEREPVLAAPVPSPELQAPSGPKSLLPFPFPHCPFFLPFRMPTAGAASLIHFPIKSSFCS

>RBM12_LPO_ENST00000374104_ENST00000421678_34252681_56344709 length=682nt
MRFQRLGHLVALMALLCGDPQEKVAEEAAEGIHSLLHITLRLKYITHDKKDQQNLKRALTKCREFLELHSSAAKCFYNCPFRIAQVFEGFLDSNELCQFIMTTFDTLKTLKHPCIQRSAGELLLTLAKNTESQFEKVPEIMGVICAQLSI
ISQPRVRQQIINTVSLFISRPKYTDIVLSFLLCHPVPYNRHLAEVWRMLSVELPSTTWILWRLLRKLQKCHNEPAQEKMAYVAVAATDALYEVFLGNRLRAATFRLFPQLLMTLLIQIHHSIGLTMSDVDIPSGLYTEQEVPSEVTPLCF
AMQATKTLLLRTCCLQEFNIMEKNKGWALLGGKDGHLQGLFLLANALLERNQLLAQKVMYLLVPLLNRGNDKHKLTSAGFFVELLRSPVAKRLPSIYSVARFKDWLQDGNHLFRILGLRGLYNLVGHQEMREDIKSLLPYIVDSLRETDE
KIVLSAIQILLQLVRTMDFTTLAAMMRTLFSLFGDVRSDVHRFSVTLFGAAIKSVKNPDKKSIENQVLDSLVPLLLYSQDENDAVAEESRQVLTICAQFLKWKLPQEVYSKDPWHIKPTEAGTICRFFEKKCKGKINILEQTLMYSKNPK
LPIRRSAVLFVGLLSKYMDHNELRRMGTDWIEDDLRDLLCDPEPSLCIIASQTLLLVQMARAEPKPKQRVNWLQKLMGRSSA

>RBM12_LPO_ENST00000374104_ENST00000543544_34252681_56344709 length=586nt
MRFQRLGHLVALMALLCGDPQEKVAEEAAEGIHSLLHITLRLKYITHDKKDQQNLKRALTKCREFLELHSSAAKCFYNCPFRIAQVFEGFLDSNELCQFIMTTFDTLKTLKHPCIQRSAGELLLTLAKNTESQFEKVPEIMGVICAQLSI
ISQPRVRQQIINTVSLFISRPKYTDIVLSFLLCHPVPYNRHLAEVWRMLSVELPSTTWILWRLLRKLQKCHNEPAQEKMAYVAVAATDALYEVFLGNRLRAATFRLFPQLLMTLLIQIHHSIGLTMSDVDIPSGLYTEQEVPSEVTPLCF
AMQATKTLLLRTCCLQEFNIMEKNKGWALLGGKDGHLQGLFLLANALLERNQLLAQKVMYLLVPLLNRGNDKHKLTSAGFFVELLRSPVAKRLPSIYSVARFKDWLQDGNHLFRILGLRGLYNLVGHQEMREDIKSLLPYIVDSLRETDE
KIVLSAIQILLQLVRTMDFTTLAAMMRTLFSLFGDVRSDVHRFSVTLFGAAIKSVKNPDKKSIENQVLDSLVPLLLYSQDENDAVAEESRQVLTICAQFLKWKLPQEVYSKDPWHIKPTEAGTICRFFGKKVQGEN

>RBM12_LPO_ENST00000374104_ENST00000582328_34252681_56344709 length=129nt
MNTVLKSKMLAKKLLGLYGTPDNIDIWIGAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWWENPGVFTNEQKDSLQKMSFSRLVCDNTRITKVPRDPFWANSYPYDFVDCSAIDKLDLSPWASVKN

>RBM12_LPO_ENST00000374114_ENST00000262290_34252681_56344709 length=81nt
MTAQESRSAVKALAGWPVSFPSEREPVLAAPVPSPELQAPSGPKSLLPFPFPHCPFFLPFRMPTAGAASLIHFPIKSSFCS

>RBM12_LPO_ENST00000374114_ENST00000421678_34252681_56344709 length=682nt
MRFQRLGHLVALMALLCGDPQEKVAEEAAEGIHSLLHITLRLKYITHDKKDQQNLKRALTKCREFLELHSSAAKCFYNCPFRIAQVFEGFLDSNELCQFIMTTFDTLKTLKHPCIQRSAGELLLTLAKNTESQFEKVPEIMGVICAQLSI
ISQPRVRQQIINTVSLFISRPKYTDIVLSFLLCHPVPYNRHLAEVWRMLSVELPSTTWILWRLLRKLQKCHNEPAQEKMAYVAVAATDALYEVFLGNRLRAATFRLFPQLLMTLLIQIHHSIGLTMSDVDIPSGLYTEQEVPSEVTPLCF
AMQATKTLLLRTCCLQEFNIMEKNKGWALLGGKDGHLQGLFLLANALLERNQLLAQKVMYLLVPLLNRGNDKHKLTSAGFFVELLRSPVAKRLPSIYSVARFKDWLQDGNHLFRILGLRGLYNLVGHQEMREDIKSLLPYIVDSLRETDE
KIVLSAIQILLQLVRTMDFTTLAAMMRTLFSLFGDVRSDVHRFSVTLFGAAIKSVKNPDKKSIENQVLDSLVPLLLYSQDENDAVAEESRQVLTICAQFLKWKLPQEVYSKDPWHIKPTEAGTICRFFEKKCKGKINILEQTLMYSKNPK
LPIRRSAVLFVGLLSKYMDHNELRRMGTDWIEDDLRDLLCDPEPSLCIIASQTLLLVQMARAEPKPKQRVNWLQKLMGRSSA

>RBM12_LPO_ENST00000374114_ENST00000543544_34252681_56344709 length=586nt
MRFQRLGHLVALMALLCGDPQEKVAEEAAEGIHSLLHITLRLKYITHDKKDQQNLKRALTKCREFLELHSSAAKCFYNCPFRIAQVFEGFLDSNELCQFIMTTFDTLKTLKHPCIQRSAGELLLTLAKNTESQFEKVPEIMGVICAQLSI
ISQPRVRQQIINTVSLFISRPKYTDIVLSFLLCHPVPYNRHLAEVWRMLSVELPSTTWILWRLLRKLQKCHNEPAQEKMAYVAVAATDALYEVFLGNRLRAATFRLFPQLLMTLLIQIHHSIGLTMSDVDIPSGLYTEQEVPSEVTPLCF
AMQATKTLLLRTCCLQEFNIMEKNKGWALLGGKDGHLQGLFLLANALLERNQLLAQKVMYLLVPLLNRGNDKHKLTSAGFFVELLRSPVAKRLPSIYSVARFKDWLQDGNHLFRILGLRGLYNLVGHQEMREDIKSLLPYIVDSLRETDE
KIVLSAIQILLQLVRTMDFTTLAAMMRTLFSLFGDVRSDVHRFSVTLFGAAIKSVKNPDKKSIENQVLDSLVPLLLYSQDENDAVAEESRQVLTICAQFLKWKLPQEVYSKDPWHIKPTEAGTICRFFGKKVQGEN

>RBM12_LPO_ENST00000374114_ENST00000582328_34252681_56344709 length=129nt
MNTVLKSKMLAKKLLGLYGTPDNIDIWIGAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWWENPGVFTNEQKDSLQKMSFSRLVCDNTRITKVPRDPFWANSYPYDFVDCSAIDKLDLSPWASVKN

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for RBM12_LPO

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for RBM12_LPO

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		BRCA	TCGA-AN-A0AM-01A	RBM12	chr20	34252681	-	LPO	chr17	34252681	+
ChimerDB		BRCA	TCGA-AN-A0AM-01A	RBM12	chr20	34252724	-	LPO	chr17	0	+
WashU		BRCA	TCGA-AN-A0AM-01A	RBM12	chr20	34252682	-	LPO	chr17	56344710	+
cBioPortal	BRCA_TCGA_PAN_CAN_ATLAS_2018	BRCA	TCGA-AN-A0AM-01	RBM12	chr20	35664760		LPO	chr17	58267349

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for RBM12_LPO

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status