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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:AGR2_ERO1L (FusionGDB2 ID:HG10551TG30001)

Fusion Gene Summary for AGR2_ERO1L

Fusion gene summary

Fusion gene information	Fusion gene name: AGR2_ERO1L
	Fusion gene ID: hg10551tg30001
		Hgene	Tgene
	Gene symbol	AGR2	ERO1L
	Gene ID	10551	30001
	Gene name	anterior gradient 2, protein disulphide isomerase family member	endoplasmic reticulum oxidoreductase 1 alpha
	Synonyms	AG-2\|AG2\|GOB-4\|HAG-2\|HEL-S-116\|HPC8\|PDIA17\|RIFTD\|XAG-2	ERO1-L\|ERO1-L-alpha\|ERO1-alpha\|ERO1L\|ERO1LA\|Ero1alpha
	Cytomap	7p21.1	14q22.1
	Type of gene	protein-coding	protein-coding
	Description	anterior gradient protein 2 homologanterior gradient homolog 2epididymis secretory protein Li 116protein disulfide isomerase family A, member 17secreted cement gland homologsecreted cement gland protein XAG-2 homolog	ERO1-like protein alphaendoplasmic oxidoreductin-1-like proteinendoplasmic reticulum oxidoreductase alphaoxidoreductin-1-L-alpha
	Modification date	20240403	20240413
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000401412, ENST00000419304, ENST00000419572, ENST00000486219,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 8 X 7 X 8=448	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 1 X 3 X 2=6
	# samples	8	17
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(8/44810)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(17/610)=4.82442843541655
Context	PubMed: AGR2 [Title/Abstract] AND ERO1L [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AGR2(16841281)-ERO1L(53124868), # samples:1

Fusion gene breakpoints across AGR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ERO1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for AGR2_ERO1L

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
AGR2	chr7	16841281	ERO1L	chr14	53124868

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for AGR2_ERO1L

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
AGR2-ERO1L	Promoter / Enhancer Hijacking M6		AGR2 promoter drives massive ERO1-like alpha expression, fueling protein disulfide formation in the ER and generating protective H2O2.		ERO1L inhibitors; ER stress/UPR inducers		Hypoxic breast and pancreatic carcinomas

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
AGR2-ERO1L	Promoter / Enhancer Hijacking M6		AGR2 promoter drives massive ERO1-like alpha expression, fueling protein disulfide formation in the ER and generating protective H2O2.	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 32724477; Title: Endoplasmic Reticulum stress-dependent expression of ERO1L promotes aerobic glycolysis in Pancreatic Cancer.	ERO1L inhibitors; ER stress/UPR inducers	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 32724477; Title: Endoplasmic Reticulum stress-dependent expression of ERO1L promotes aerobic glycolysis in Pancreatic Cancer.	Hypoxic breast and pancreatic carcinomas	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 32724477; Title: Endoplasmic Reticulum stress-dependent expression of ERO1L promotes aerobic glycolysis in Pancreatic Cancer.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	AGR2	GO:1903896	positive regulation of IRE1-mediated unfolded protein response	23220234
Hgene	AGR2	GO:1903899	positive regulation of PERK-mediated unfolded protein response	23220234
Tgene	ERO1L	GO:0051085	chaperone cofactor-dependent protein refolding	11707400

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Fusion Genomic Features for AGR2_ERO1L

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
AGR2	chr7	16841281	-	ERO1L	chr14	53124868	-	4.91e-04	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for AGR2_ERO1L

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000401412	ENST00000395686	AGR2	chr7	16841281	-	ERO1L	chr14	53124868	-
Frame-shift	ENST00000419304	ENST00000395686	AGR2	chr7	16841281	-	ERO1L	chr14	53124868	-
In-frame	ENST00000419572	ENST00000395686	AGR2	chr7	16841281	-	ERO1L	chr14	53124868	-

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000419572	ENST00000395686	AGR2	chr7	16841281	ERO1L	chr14	53124868	199	742

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000419572	ENST00000395686	AGR2	chr7	16841281	ERO1L	chr14	53124868	1.92e-02	9.81e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for AGR2_ERO1L

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for AGR2_ERO1L

In-frame Fusion Transcript Sequences.

>AGR2_ERO1L_ENST00000419572_ENST00000395686_16841281_53124868 length=4572nt 
 Breakpoint=199nt
ATGTCAAATTACACTGATGCTGAGTCAAGCTTCTCAAAGCAAGAGATAATCAGAGTTGCCATGGAGAAAATTCCAGTGTCAGCATTCTTGCTCCTTGTGGCCCTCTCCTACACTCTGGCCAGAGATACCACAGTCAAACCTGGAGCCAAA
AAGGACACAAAGGACTCTCGACCCAAACTGCCCCAGACCCTCTCCAGAGAGAACACTTTTTACAGTTGGCTAGAAGGTCTCTGTGTAGAAAAAAGAGCATTCTACAGACTTATATCTGGCCTACATGCAAGCATTAATGTGCATTTGAGT
GCAAGATATCTTTTACAAGAGACCTGGTTAGAAAAGAAATGGGGACACAACATTACAGAATTTCAACAGCGATTTGATGGAATTTTGACTGAAGGAGAAGGTCCAAGAAGGCTTAAGAACTTGTATTTTCTCTACTTAATAGAACTAAGG
GCTTTATCCAAAGTGTTACCATTCTTCGAGCGCCCAGATTTTCAACTCTTTACTGGAAATAAAATTCAGGATGAGGAAAACAAAATGTTACTTCTGGAAATACTTCATGAAATCAAGTCATTTCCTTTGCATTTTGATGAGAATTCATTT
TTTGCTGGGGATAAAAAAGAAGCACACAAACTAAAGGAGGACTTTCGACTGCATTTTAGAAATATTTCAAGAATTATGGATTGTGTTGGTTGTTTTAAATGTCGTCTGTGGGGAAAGCTTCAGACTCAGGGTTTGGGCACTGCTCTGAAG
ATCTTATTTTCTGAGAAATTGATAGCAAATATGCCAGAAAGTGGACCTAGTTATGAATTCCATCTAACCAGACAAGAAATAGTATCATTATTCAACGCATTTGGAAGAATTTCTACAAGTGTGAAAGAATTAGAAAACTTCAGGAACTTG
TTACAGAATATTCATTAAAGAAAACAAGCTGATATGTGCCTGTTTCTGGACAATGGAGGCGAAAGAGTGGAATTTCATTCAAAGGCATAATAGCAATGACAGTCTTAAGCCAAACATTTTATATAAAGTTGCTTTTGTAAAGGAGAATTA
TATTGTTTTAAGTAAACACATTTTTAAAAATTGTGTTAAGTCTATGTATAATACTACTGTGAGTAAAAGTAATACTTTAATAATGTGGTACAAATTTTAAAGTTTAATATTGAATAAAAGGAGGATTATCAAATTCATATATGATAAAAG
TGAATGTTCTAAGTCTCTCAAACTAGCGTTTTATGTAATAATATGTAATATAAATAAAACTATGGTAAATGTGACAAGCATTTAATAGGAAAATGCTAAGGAGGCCTCATAAATGACCCATAATTACCAACGTAGAATTTTTCAGTACAT
TTAGGGTTGCTGGATTTAGCAAATAAAAATAAAGATTGCCCAGTTAGATTTGAATTTCAGATAAACAATTAGTTTTTTAATATTTTACATGGAATATTTGGAAAATACTTATACTAAAAAATTATTTGTTTGAAATTCAAATTTAACTGG
GAGTCTTGTATTTTATCTGGCAATCCTAAAATACATTGGTATGAAACAAATCACTTTTAGAAGTATATTGCTATTTTGATTGGGTTGTTTTTGTGTGTAGAAACGTACAATAACAACTCAAAGGCACAGGAGATTTCTAAACATTGTGAA
AAGTTGAATAGATTATATATTTATTCTCATAATACTTTCACTAATACTAAATAAAATTTGGGGAACACTTTTTATTTTTATATAATTTCCAATTTACAGAAAAGTTTCAAAAATAGTACAAAGAGCTCTCTTACCCAGATTCACTAATTG
TTCATACGTGCTTTATCTTTCATGCTTTCTCTGTACACACACACACACACACAAATTTTTCCTCAATCATTTGAAAGTCAGTTATAGGCATCATGCCCCTTAAACCCTAAATACTTCAGTGTGTAATACTGAATAATTACTAAAAATGAT
TTTCTCAGAAAAAAAAACTCCCACAATTCTGGAACTATAATACTGTAAGCCTTAGAATAAATAATACTTTCAAGTTCCAATCTAAAGTTCTTTTTGAGTTTTGTTGCCCGTTTTATGCTTGATGTGTATAGTAATAGGGTAGGCTATTTA
TTTTATTAAAATTTTTTTTAGAGACAAGGTTTTGCTGTGTTGCCCAAGCTGGAACTTGAACGACTGGGCTGAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGGAATACAGGTGTCTGCCACCATACCCAGTTTCATTTTTGTTTT
TTATACCCGAAGTTCATTTCCTTTGTCTCCCTAAAACTGAACTGTAATTTTGGGAGGTTTTCATTAGTGGAAGCTCTTCATTTATAAAGCTATTTGAAGGGGTTTAGGAATTTATATCACATGGTAATTGTAGAGAAAAAGAAGCTATAT
ACCTCAAAATCGTGCCCTCTTTACATATGTCTTATCAGGTATAACATGTTGAAATGTCACATTAGTAGTAAAGTGGGGTTTATTTATATAGTGGTTAAGAAATGTCAGTTTACACTGCTGTATACTTCTTCTTCTGTGTCCCTAAGGCCT
GGTACAGTGCCAAGCACATACTTGGTATCCAATAAATATTTGTTGGATGAATGTATGCATATGTATTCAGTATATTTTAAATGAATAATCACAGAAGTAAGTTTAATAATTTGTCCTATTTTTCTCTGTCACTTCCTTTTTCTCTAAGGC
AGGAAAGGAAAGACATTAAACCATTAATTAAGTCAATCCTCTTGGAGACTCAAAAGACTATGAAGTGATCACTCTATATAAAATATAAATACAGTGTGGGTTCAAATGGCCATTTTTTGTGTGTCCCTCTCTCTCATCTTATGCTTCCCT
TCCTTTTTTTATTTTTATTTTTTGGAGACGGAGTCTTGCTGTGTCGCCCAGGTTGGAGTGCAGTGGCGTGATCTTAGCTCACTGCAAGCTCTGCCTTCCAGGTTCACGCCATTCTTCTGCCTCAGCCCCCTGAGTAGCTGGGACTACAGG
CGCCCGCCACCACGCCCGGCTAATTTTTTTTTTTTTTTTTTTGTATTTTTAGTAGAGGCAGTGTTTCACCGTGTTAGCCAGGATGGTCTTGATCTCCTGACCTCGTGATCCACCCACCTCGACCTCCCAAAGTGCTGGGATTACAGGCGT
GAGCCACCACGCCCGGCCTCTTTTTTTTTTAGCTGCCAATCTTTTTGAAGGAATATTCTTACCTCTACTTTGTCACCTTCTACTGGCTCCTTAACTAAAATCTGCCATTTGGCTCTCTGGTTAACAGTCCCTTCCTGTAAAGTCTAAAAT
CTTAATTCTAAATCCACAGTTTAATTCACAAGCTAGTACTTGACTTTTTTTCTGTATTTGACATTTTTGACAACCCCTACTTTAAAGATTTATTCCCTTGACTTCTTACATTTTGCTCACTCCTGAACCACCCCCCACCTTTTGGCCTCT
TCATTTATTCCTTAAATGTTATTCCTCAGACCTCCATTTTTTTTTTCTCTCTTAATCACAACACCACTTCTCACGCTTGGGTAATTTTAATTCAGCAGTTCCTAAATCCTTATCTTTAGCCAGACTCCTCAATCCATCTGCCTGTTGCAC
TTTTCTTGGTTGTCCCAGAGACACCTGTGTGTGTCTTAAAACATTCATTCTCTGCAAAACCTACTCTAATGCCTGTGTCCCTTACTTTGGTTAATTTTAGAACCATTATATTCTAAGTTTTCTAGGCTCATTCCTCTCCTCCACCTTCCC
CTATCATTTAGTGTCTAAGTTTTACTGATTTTATCTCCACCTCTCTGATACATCACTCTTTCATCTTCATTGCTATTATTAATAAATACCTACAGTACTAACCTGCCTCCTATACCTAGCTGGTCTCCTCTCTGTTGCTCAATGTTACCA
CAGCAGGCTTTCTAGAAGCACTCTGACAGTGTTACTCCCTAATATCCTTCAGTGACTTCAGGAACTTTCAGGAGAAAGCCAAACTCCTCTGTTTGGTGTACAAGGTCTTCTGATGTGTTTCCTCCACCGAATGTTCTGGTGAAACAGACT
TACACTTCTTCAGAAGCCACATTTGGCCAGGCCTCCCGCCTTGGTAAATGCTGTACTCTTTGCATCAAGTATGCTAGTCATCCTTCCCCACTTGGAAAATTCCTATGCATCTTGCAGGCCTGACATAAGCATTTCCTCTGTGAAACCTCC
TTTGCTCCACTCAAGGAGAGTCATCTAACTTCCACTTTCGTGTCACCACTGTAATTACAACCTACCTCTATTGTATGTCACTTAAATCGTACTGTATTGTTTTATTTTTCAAAAGTCTTTACTAGAATGTGAGCTCCTTAAGGGCAGGAA
AAGGAACCTTTTTATTTTTTGCATCTCCATAGCATAGTTTTTGGCATATGAATGTTTAATAAATGTTTGTTGAATAAATTGATTTTAAAGTGACATCTTTATTATATTAGAGGTCCTACCTATATTCCAAATACTTTCACTCCCTTCACT
TTACAGCAAGGGTCAGTAGAGTCCCAAGGATTTGTAGACTTTAGGGGGTCAATAAAGCTGAAATTGTATTCA

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for AGR2_ERO1L

In-frame Fusion Protein Sequences.

>AGR2_ERO1L_ENST00000419572_ENST00000395686_16841281_53124868 length=742nt
MVAPGAALSDLSPAPSGSGRQHKAVAMAEAAAAAGGTGLGAGASYGSAADRDRDPDPDRAGRRLRVLSGHLLGRPREALSTNECKARRAASAATAAPTATPAAQESGTIPKKRQEVMKWNGWGYNDSKFIFNKKGQIELTGKRYPLSGMG
LPTFKEWIQNTLGVNVEHKTTSKASLNPSDTPPSVVNEDFLHDLKETNISYSQEADDRVFRAHGHCLHEIFLLREGMFERIPDIVLWPTCHDDVVKIVNLACKYNLCIIPIGGGTSVSYGLMCPADETRTIISLDTSQMNRILWVDENNL
TAHVEAGITGQELERQLKESGYCTGHEPDSLEFSTVGGWVSTRASGMKKNIYGNIEDLVVHIKMVTPRGIIEKSCQGPRMSTGPDIHHFIMGSEGTLGVITEATIKIRPVPEYQKYGSVAFPNFEQGVACLREIAKQRCAPASIRLMDNK
QFQFGHALKPQVSSIFTSFLDGLKKFYITKFKGFDPNQLSVATLLFEGDREKVLQHEKQVYDIAAKFGGLAAGEDNGQRGYLLTYVIAYIRDLALEYYVLGESFETSAPWDRVVDLCRNVKERITRECKEKGVQFAPFSTCRQFCLELNG
LAVKLQSECHPDTCTQMTATEQWIFLCAAHKTPKECPAIDYTRHTLDGAACLLNSNKYFPSRVSIKESSVAKLGSVCRRIYRIFSHAYFHHRQIFDEYENETFLCHRFTKFVMKYNLMSKDNLIVPILEEEVQNSVSGESEA

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for AGR2_ERO1L

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for AGR2_ERO1L

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		STAD	TCGA-FP-8211-01A	AGR2	chr7	16841281	-	ERO1L	chr14	53124868	-

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for AGR2_ERO1L

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status