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Fusion gene:ARPP21_FRMD4A (FusionGDB2 ID:HG10777TG55691) |
Fusion Gene Summary for ARPP21_FRMD4A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARPP21_FRMD4A | Fusion gene ID: hg10777tg55691 | Hgene | Tgene | Gene symbol | ARPP21 | FRMD4A | Gene ID | 10777 | 55691 |
| Gene name | cAMP regulated phosphoprotein 21 | FERM domain containing 4A | |
| Synonyms | ARPP-21|R3HDM3|RCS|TARPP | CCAFCA|FRMD4|bA295P9.4 | |
| Cytomap | 3p22.3 | 10p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cAMP-regulated phosphoprotein 21R3H domain containing 3cAMP regulated phosphoprotein 21kDacyclic AMP-regulated phosphoprotein, 21 kDthymocyte cAMP-regulated phosphoprotein | FERM domain-containing protein 4AFERM domain containing 4 | |
| Modification date | 20240305 | 20240305 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000187397, ENST00000337271, ENST00000396481, ENST00000396482, ENST00000412048, ENST00000417925, ENST00000427542, ENST00000428373, ENST00000432682, ENST00000436702, ENST00000438071, ENST00000441454, ENST00000444190, ENST00000458225, ENST00000474696, ENST00000476052, | ||
| Fusion gene scores | * DoF score | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 1 X 2 X 2=4 | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 9 X 18 X 12=1944 |
| # samples | 2 | 26 | |
| ** MAII score | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(2/4*10)=2.32192809488736 | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(26/1944*10)=-2.90244469057733 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ARPP21 [Title/Abstract] AND FRMD4A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ARPP21(35725307)-FRMD4A(14125812), # samples:1 | ||
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Fusion Gene Breakpoints for ARPP21_FRMD4A |
| RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ARPP21 | chr3 | 35725307 | FRMD4A | chr10 | 14125812 |
| ARPP21 | chr3 | 35683815 | FRMD4A | chr10 | 14083813 |
| DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | SV type |
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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for ARPP21_FRMD4A |
| To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence. |
| Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions | Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity | Epigenetic Reprogramming / Histone Modifier Dysregulation | Chromatin Remodeling Dysregulation | Condensate-Driven Transcriptional Rewiring / LLP | Promoter / Enhancer Hijacking | Dominant-Negative Antagonism | Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation | Subcellular Mislocalization / Spatial Dysregulation | Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade |  |  |  |  |  |  |  |  |  |  |
* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
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Fusion Genomic Features for ARPP21_FRMD4A |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| ARPP21 | chr3 | 35725307 | + | FRMD4A | chr10 | 14125812 | - | 1.19e-04 | 1.00e+00 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF). |
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Fusion Gene ORF Annotations for ARPP21_FRMD4A |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000187397 | ENST00000493380 | ARPP21 | chr3 | 35725307 | + | FRMD4A | chr10 | 14125812 | - |
| 5CDS-3UTR | ENST00000337271 | ENST00000493380 | ARPP21 | chr3 | 35725307 | + | FRMD4A | chr10 | 14125812 | - |
| 5CDS-3UTR | ENST00000396481 | ENST00000493380 | ARPP21 | chr3 | 35725307 | + | FRMD4A | chr10 | 14125812 | - |
| 5CDS-3UTR | ENST00000396482 | ENST00000493380 | ARPP21 | chr3 | 35725307 | + | FRMD4A | chr10 | 14125812 | - |
| 5CDS-3UTR | ENST00000412048 | ENST00000493380 | ARPP21 | chr3 | 35725307 | + | FRMD4A | chr10 | 14125812 | - |
| 5CDS-3UTR | ENST00000417925 | ENST00000493380 | ARPP21 | chr3 | 35725307 | + | FRMD4A | chr10 | 14125812 | - |
| 5CDS-3UTR | ENST00000427542 | ENST00000493380 | ARPP21 | chr3 | 35725307 | + | FRMD4A | chr10 | 14125812 | - |
| 5CDS-3UTR | ENST00000428373 | ENST00000493380 | ARPP21 | chr3 | 35725307 | + | FRMD4A | chr10 | 14125812 | - |
| 5CDS-3UTR | ENST00000432682 | ENST00000493380 | ARPP21 | chr3 | 35725307 | + | FRMD4A | chr10 | 14125812 | - |
| 5CDS-3UTR | ENST00000436702 | ENST00000493380 | ARPP21 | chr3 | 35725307 | + | FRMD4A | chr10 | 14125812 | - |
| 5CDS-3UTR | ENST00000438071 | ENST00000493380 | ARPP21 | chr3 | 35725307 | + | FRMD4A | chr10 | 14125812 | - |
| 5CDS-3UTR | ENST00000441454 | ENST00000493380 | ARPP21 | chr3 | 35725307 | + | FRMD4A | chr10 | 14125812 | - |
| 5CDS-3UTR | ENST00000444190 | ENST00000493380 | ARPP21 | chr3 | 35725307 | + | FRMD4A | chr10 | 14125812 | - |
| 5CDS-3UTR | ENST00000458225 | ENST00000493380 | ARPP21 | chr3 | 35725307 | + | FRMD4A | chr10 | 14125812 | - |
| 5CDS-3UTR | ENST00000474696 | ENST00000493380 | ARPP21 | chr3 | 35725307 | + | FRMD4A | chr10 | 14125812 | - |
| ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| ENST00000187397 | ENST00000493380 | ARPP21 | chr3 | 35725307 | FRMD4A | chr10 | 14125812 | 0.00e+00 | 7.88e-01 |
| ENST00000337271 | ENST00000493380 | ARPP21 | chr3 | 35725307 | FRMD4A | chr10 | 14125812 | 0.00e+00 | 7.92e-01 |
| ENST00000396481 | ENST00000493380 | ARPP21 | chr3 | 35725307 | FRMD4A | chr10 | 14125812 | 0.00e+00 | 8.94e-01 |
| ENST00000396482 | ENST00000493380 | ARPP21 | chr3 | 35725307 | FRMD4A | chr10 | 14125812 | 0.00e+00 | 7.24e-01 |
| ENST00000412048 | ENST00000493380 | ARPP21 | chr3 | 35725307 | FRMD4A | chr10 | 14125812 | 0.00e+00 | 7.55e-01 |
| ENST00000417925 | ENST00000493380 | ARPP21 | chr3 | 35725307 | FRMD4A | chr10 | 14125812 | 0.00e+00 | 8.80e-01 |
| ENST00000427542 | ENST00000493380 | ARPP21 | chr3 | 35725307 | FRMD4A | chr10 | 14125812 | 0.00e+00 | 8.79e-01 |
| ENST00000428373 | ENST00000493380 | ARPP21 | chr3 | 35725307 | FRMD4A | chr10 | 14125812 | 0.00e+00 | 8.85e-01 |
| ENST00000432682 | ENST00000493380 | ARPP21 | chr3 | 35725307 | FRMD4A | chr10 | 14125812 | 0.00e+00 | 8.12e-01 |
| ENST00000436702 | ENST00000493380 | ARPP21 | chr3 | 35725307 | FRMD4A | chr10 | 14125812 | 0.00e+00 | 8.71e-01 |
| ENST00000438071 | ENST00000493380 | ARPP21 | chr3 | 35725307 | FRMD4A | chr10 | 14125812 | 0.00e+00 | 9.77e-01 |
| ENST00000441454 | ENST00000493380 | ARPP21 | chr3 | 35725307 | FRMD4A | chr10 | 14125812 | 0.00e+00 | 8.19e-01 |
| ENST00000444190 | ENST00000493380 | ARPP21 | chr3 | 35725307 | FRMD4A | chr10 | 14125812 | 0.00e+00 | 7.59e-01 |
| ENST00000458225 | ENST00000493380 | ARPP21 | chr3 | 35725307 | FRMD4A | chr10 | 14125812 | 0.00e+00 | 7.92e-01 |
| ENST00000474696 | ENST00000493380 | ARPP21 | chr3 | 35725307 | FRMD4A | chr10 | 14125812 | 0.00e+00 | 7.35e-01 |
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Fusion Protein Retained/Non-Retained Functional Features for ARPP21_FRMD4A |
| Protein Level Annotation from FGviewer * Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS. |
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| - In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length). |
| No matching images found for ${hg}_${tg}. |
| - In-frame and retained protein feature among the 13 regional features (texts). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - Retained PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Fusion Transcript Sequence for ARPP21_FRMD4A |
| In-frame Fusion Transcript Sequences. |
| N-Truncated Transcript (5UTR-3CDS) Sequences |
| C-Truncated Transcript (5CDS-3UTR) Sequences |
>ARPP21_FRMD4A_ENST00000187397_ENST00000493380_35725307_14125812 length=717nt Breakpoint=717nt GTGCTATTAGATTTGCAAATTGCTGATCTCCCAGTGACTTTCCCTCTTAGATCCCAGTTGAGTATGGTTACCTTGAGAACTGTGGTATTAGCCATGTTAGAGCATGCTCCACTGGGGAGTTCTGTGCAGTCTATTTTTAATGCTATTTAA TGAAGGAGCGAGCGCCTCACTCAGCAATAAAAGAAGCATGAGGGAAGACAGAGCAGTGCATGGTTATGGATACTGGACAAGGATATTTGGAAAGGTTGACGATGTGTCACACTGTGTAAGGGAATCGCATGGAGATGGGCATTCCGAACT GTTAATGGGGACATGGGACTCCAGTTGTCTCTGATCACTTGTGTGGATTTTCCTGGCGTAGAACGACAGAAGCCGCTAGTAAGTCGCCAAGACCTACAGCAGGAATTCTGCACCAAAGGGCATAAAATCTTGTTATTTTAATTTGCATCT GGGAGAATGTCTGAGCAAGGAGACCTGAATCAGGCAATAGCAGAGGAAGGAGGGACTGAGCAGGAGACGGCCACTCCAGAGAACGGCATTGTTAAATCAGAAAGTCTGGATGAAGAGGAGAAACTGGAACTGCAGAGGCGGCTGGAGGCT CAGAATCAAGAAAGAAGAAAATCCAAGTCAGGAGCAGGAAAAGGTAAACTGACTCGCAGCCTTGCTGTCTGTGAGGAATCTTCTGCCAGACCAGGAGGTGAAAGTCTTCAGGATCAG >ARPP21_FRMD4A_ENST00000337271_ENST00000493380_35725307_14125812 length=486nt Breakpoint=486nt CAGTTCGATCAAGGTTGACGATGTGTCACACTGTGTAAGGGAATCGCATGGAGATGGGCATTCCGAACTGTTAATGGGGACATGGGACTCCAGTTGTCTCTGATCACTTGTGTGGATTTTCCTGGCGTAGAACGACAGAAGCCGCTAGTA AGTCGCCAAGACCTACAGCAGGAATTCTGCACCAAAGGGCATAAAATCTTGTTATTTTAATTTGCATCTGGGAGAATGTCTGAGCAAGGAGACCTGAATCAGGCAATAGCAGAGGAAGGAGGGACTGAGCAGGAGACGGCCACTCCAGAG AACGGCATTGTTAAATCAGAAAGTCTGGATGAAGAGGAGAAACTGGAACTGCAGAGGCGGCTGGAGGCTCAGAATCAAGAAAGAAGAAAATCCAAGTCAGGAGCAGGAAAAGGTAAACTGACTCGCAGCCTTGCTGTCTGTGAGGAATCT TCTGCCAGACCAGGAGGTGAAAGTCTTCAGGATCAG >ARPP21_FRMD4A_ENST00000396481_ENST00000493380_35725307_14125812 length=533nt Breakpoint=533nt AACAGATTTTAACTCTGAAAAGCCATTTCCAGTGTCTATAGACTATTGTGAGCCTGGAGAAGTAGCATTTAGTTGGGATAGCTTCACTAGAGCTGCCTGCCAAAGACTTCCTTCCACAGGATCTTGTCGCACCAGCAACTGACAGGAGCT TGGGAGCTCGGGAGCTTGGGAGAGGGCTTATGTTTTTAATAATGTAGCTGTCAGTTCGAAGCCTGGAAATGTTGACCCTCAAAGGGCATAAAATCTTGTTATTTTAATTTGCATCTGGGAGAATGTCTGAGCAAGGAGACCTGAATCAGG CAATAGCAGAGGAAGGAGGGACTGAGCAGGAGACGGCCACTCCAGAGAACGGCATTGTTAAATCAGAAAGTCTGGATGAAGAGGAGAAACTGGAACTGCAGAGGCGGCTGGAGGCTCAGAATCAAGAAAGAAGAAAATCCAAGTCAGGAG CAGGAAAAGGTAAACTGACTCGCAGCCTTGCTGTCTGTGAGGAATCTTCTGCCAGACCAGGAGGTGAAAGTCTTCAGGATCAG >ARPP21_FRMD4A_ENST00000396482_ENST00000493380_35725307_14125812 length=551nt Breakpoint=551nt AGAGAAGAAGCAGGCAGCTTGAGACAGGTGGAGCTGGATCAAGCTGTGAACGTGATTTGCTGGAAGCTGGTCATTAGTGTTGACGATGTGTCACACTGTGTAAGGGAATCGCATGGAGATGGGCATTCCGAACTGTTAATGGGGACATGG GACTCCAGTTGTCTCTGATCACTTGTGTGGATTTTCCTGGCGTAGAACGACAGAAGCCGCTAGTAAGTCGCCAAGACCTACAGCAGGAATTCTGCACCAAAGGGCATAAAATCTTGTTATTTTAATTTGCATCTGGGAGAATGTCTGAGC AAGGAGACCTGAATCAGGCAATAGCAGAGGAAGGAGGGACTGAGCAGGAGACGGCCACTCCAGAGAACGGCATTGTTAAATCAGAAAGTCTGGATGAAGAGGAGAAACTGGAACTGCAGAGGCGGCTGGAGGCTCAGAATCAAGAAAGAA GAAAATCCAAGTCAGGAGCAGGAAAAGGTAAACTGACTCGCAGCCTTGCTGTCTGTGAGGAATCTTCTGCCAGACCAGGAGGTGAAAGTCTTCAGGATCAG >ARPP21_FRMD4A_ENST00000412048_ENST00000493380_35725307_14125812 length=639nt Breakpoint=639nt ATTAGAGAAGAAGCAGGCAGCTTGAGACAGGTGGAGCTGGATCAAGCTGTGAACGTGATTTGCTGGAAGCTGGTCATTAGTGTTAGAAACCCCGTCTTATTTATTTCATCCTTCACCCTACCATGATTATTGCAATTATTATTATTTATT TTTCATCTTTTTTCAGGTTGACGATGTGTCACACTGTGTAAGGGAATCGCATGGAGATGGGCATTCCGAACTGTTAATGGGGACATGGGACTCCAGTTGTCTCTGATCACTTGTGTGGATTTTCCTGGCGTAGAACGACAGAAGCCGCTA GTAAGTCGCCAAGACCTACAGCAGGAATTCTGCACCAAAGGGCATAAAATCTTGTTATTTTAATTTGCATCTGGGAGAATGTCTGAGCAAGGAGACCTGAATCAGGCAATAGCAGAGGAAGGAGGGACTGAGCAGGAGACGGCCACTCCA GAGAACGGCATTGTTAAATCAGAAAGTCTGGATGAAGAGGAGAAACTGGAACTGCAGAGGCGGCTGGAGGCTCAGAATCAAGAAAGAAGAAAATCCAAGTCAGGAGCAGGAAAAGGTAAACTGACTCGCAGCCTTGCTGTCTGTGAGGAA TCTTCTGCCAGACCAGGAGGTGAAAGTCTTCAGGATCAG >ARPP21_FRMD4A_ENST00000417925_ENST00000493380_35725307_14125812 length=475nt Breakpoint=475nt AGGTTGACGATGTGTCACACTGTGTAAGGGAATCGCATGGAGATGGGCATTCCGAACTGTTAATGGGGACATGGGACTCCAGTTGTCTCTGATCACTTGTGTGGATTTTCCTGGCGTAGAACGACAGAAGCCGCTAGTAAGTCGCCAAGA CCTACAGCAGGAATTCTGCACCAAAGGGCATAAAATCTTGTTATTTTAATTTGCATCTGGGAGAATGTCTGAGCAAGGAGACCTGAATCAGGCAATAGCAGAGGAAGGAGGGACTGAGCAGGAGACGGCCACTCCAGAGAACGGCATTGT TAAATCAGAAAGTCTGGATGAAGAGGAGAAACTGGAACTGCAGAGGCGGCTGGAGGCTCAGAATCAAGAAAGAAGAAAATCCAAGTCAGGAGCAGGAAAAGGTAAACTGACTCGCAGCCTTGCTGTCTGTGAGGAATCTTCTGCCAGACC AGGAGGTGAAAGTCTTCAGGATCAG >ARPP21_FRMD4A_ENST00000427542_ENST00000493380_35725307_14125812 length=499nt Breakpoint=499nt GATGCATTTAGTGTTTTCATAGATAGGTTGACGATGTGTCACACTGTGTAAGGGAATCGCATGGAGATGGGCATTCCGAACTGTTAATGGGGACATGGGACTCCAGTTGTCTCTGATCACTTGTGTGGATTTTCCTGGCGTAGAACGACA GAAGCCGCTAGTAAGTCGCCAAGACCTACAGCAGGAATTCTGCACCAAAGGGCATAAAATCTTGTTATTTTAATTTGCATCTGGGAGAATGTCTGAGCAAGGAGACCTGAATCAGGCAATAGCAGAGGAAGGAGGGACTGAGCAGGAGAC GGCCACTCCAGAGAACGGCATTGTTAAATCAGAAAGTCTGGATGAAGAGGAGAAACTGGAACTGCAGAGGCGGCTGGAGGCTCAGAATCAAGAAAGAAGAAAATCCAAGTCAGGAGCAGGAAAAGGTAAACTGACTCGCAGCCTTGCTGT CTGTGAGGAATCTTCTGCCAGACCAGGAGGTGAAAGTCTTCAGGATCAG >ARPP21_FRMD4A_ENST00000428373_ENST00000493380_35725307_14125812 length=1283nt Breakpoint=1283nt GGGTGGGACTGGCAGAGCTACGGACAGGTGGGAGCAGTCAGACAGCCTGAGAGAGGGAGACCAGAACGCAAAGAGAGCGAGAGCATTAAGTAGGCAGGGAGAGGCACACAGAAAGATAGACAGCAACACTCGCGTGCTCCCTCCCTCCAC ACGCCCTCCTCTTACCGAGCGAAGCGGCCAGGGGCACAGAGTGGGAGAGGACTGTGGGCACAGAAGACCGGAAGAGGGACGCTGCATTGCTGGTGGGACGGAGGGATTCGGACGGACGGACAGACCAGCGCACAGACTGGCAGCCTGCGA GAGTGGCAGCTTTGAGAGCAGAGCGCAGCAAAGCGAGAATCCCGCGCCGAGCTGCTAGTCGGACCCACAGACGGTCGGACTGACAGACGTGCAGACGGACAGAAGAGCAGACAGGAGGCGGGGGCGCGTTCACTCCCGGCGGCCAGCCGG CCAGAGAAGGCGGCGGTGGCACCTTCTGAGCGCGTCCGGAGCAGAGACCAGCAGCAGCAGGGGCAGCGGGGACACAAGCCGCGACCGAGCCGCCGCCGCAGCCCTGGCTGCCACAGCTGTGTGGGATCCCAGCCGACACTGCAGAAAGCT CCTTTTACTAGCAGTTAAATAAATCGACCAAAAACAAAACAAACAAACAAACCCAACAACAACAACAACAACAAAAGCCAAGCCAAAAGCCAAAACAAACAAATCCAGCCAAATCAATCATTGAGAAACAATAATATTAATAAAATCCAA AACTAAATCAAACCAATCAAGGCACCAAGACGCAGGGGGGATATCCACAGTTCGATCAAGGTTGACGATGTGTCACACTGTGTAAGGGAATCGCATGGAGATGGGCATTCCGAACTGTTAATGGGGACATGGGACTCCAGTTGTCTCTGA TCACTTGTGTGGATTTTCCTGGCGTAGAACGACAGAAGCCGCTAGTAAGTCGCCAAGACCTACAGCAGGAATTCTGCACCAAAGGGCATAAAATCTTGTTATTTTAATTTGCATCTGGGAGAATGTCTGAGCAAGGAGACCTGAATCAGG CAATAGCAGAGGAAGGAGGGACTGAGCAGGAGACGGCCACTCCAGAGAACGGCATTGTTAAATCAGAAAGTCTGGATGAAGAGGAGAAACTGGAACTGCAGAGGCGGCTGGAGGCTCAGAATCAAGAAAGAAGAAAATCCAAGTCAGGAG CAGGAAAAGGTAAACTGACTCGCAGCCTTGCTGTCTGTGAGGAATCTTCTGCCAGACCAGGAGGTGAAAGTCTTCAGGATCAG >ARPP21_FRMD4A_ENST00000432682_ENST00000493380_35725307_14125812 length=640nt Breakpoint=640nt GAAGAAGCAGGCAGCTTGAGACAGGTGGAGCTGGATCAAGCTGTGAACGTGATTTGCTGGAAGCTGGTCATTAGTGTTGACGATGTGTCACACTGTGTAAGGGAATCGCATGGAGATGGGCATTCCGAACTGTTAATGGGGACATGGGAC TCCAGTTGTCTCTGATCACTTGTGTGGATTTTCCTGGCGTAGAACGACAGAAGCCGCTAGTAAGTCGCCAAGACCTACAGCAGGAATTCTGCACCAAAGCTTAAAAAAGTGAGGAGGAAGTAAATGCTAAATTATTCATGAGCCTCATTT GACAGCACATCAGAAGGGGAAGTGTCAGGGGTTTTATAAAGGGCATAAAATCTTGTTATTTTAATTTGCATCTGGGAGAATGTCTGAGCAAGGAGACCTGAATCAGGCAATAGCAGAGGAAGGAGGGACTGAGCAGGAGACGGCCACTCC AGAGAACGGCATTGTTAAATCAGAAAGTCTGGATGAAGAGGAGAAACTGGAACTGCAGAGGCGGCTGGAGGCTCAGAATCAAGAAAGAAGAAAATCCAAGTCAGGAGCAGGAAAAGGTAAACTGACTCGCAGCCTTGCTGTCTGTGAGGA ATCTTCTGCCAGACCAGGAGGTGAAAGTCTTCAGGATCAG >ARPP21_FRMD4A_ENST00000436702_ENST00000493380_35725307_14125812 length=440nt Breakpoint=440nt AGAAGTCGAGGGTCATTTGTTCAAAAGTTGGAGAAATATCCTCTTTTGTTGCTTCTTCTACTCTGTAGTGGAGAATGGGGAACTGGTAGTTGTGTGGGAGTTATGTGTCTCTAAGATTTGTCGACCCATTTTGATGGCAAGGGCATAAAA TCTTGTTATTTTAATTTGCATCTGGGAGAATGTCTGAGCAAGGAGACCTGAATCAGGCAATAGCAGAGGAAGGAGGGACTGAGCAGGAGACGGCCACTCCAGAGAACGGCATTGTTAAATCAGAAAGTCTGGATGAAGAGGAGAAACTGG AACTGCAGAGGCGGCTGGAGGCTCAGAATCAAGAAAGAAGAAAATCCAAGTCAGGAGCAGGAAAAGGTAAACTGACTCGCAGCCTTGCTGTCTGTGAGGAATCTTCTGCCAGACCAGGAGGTGAAAGTCTTCAGGATCAG >ARPP21_FRMD4A_ENST00000438071_ENST00000493380_35725307_14125812 length=365nt Breakpoint=365nt ATTCACAAGTGTGTGTAAAGGGGGTGTGGATGGGACAACTGCATCTGCCTCTTGTGCATGCCTTGGGGCATAAAATCTTGTTATTTTAATTTGCATCTGGGAGAATGTCTGAGCAAGGAGACCTGAATCAGGCAATAGCAGAGGAAGGAG GGACTGAGCAGGAGACGGCCACTCCAGAGAACGGCATTGTTAAATCAGAAAGTCTGGATGAAGAGGAGAAACTGGAACTGCAGAGGCGGCTGGAGGCTCAGAATCAAGAAAGAAGAAAATCCAAGTCAGGAGCAGGAAAAGGTAAACTGA CTCGCAGCCTTGCTGTCTGTGAGGAATCTTCTGCCAGACCAGGAGGTGAAAGTCTTCAGGATCAG >ARPP21_FRMD4A_ENST00000441454_ENST00000493380_35725307_14125812 length=1013nt Breakpoint=1013nt AGCATTTAGTTGGGATAGCTTCACTAGAGCTGCCTGCCAAAGACTTCCTTCCACAGGATCTTGTCGCACCAGCAACTGACAGGAGCTTGGGAGCTCGGGAGCTTGGGAGAGGGCTTATGTTTTTAATAATGTAGCTGTCAGTTCGAAGCC TGGAAATGTTGACCCTCAAAGGTTTATTGCCAAAATTAGATACCATATTTATGCTGAATTATTACCTTTTCAATAGTTTTTTTTGACCTTGCAGACTACTGTATTCTTTATACCTAGGGAAGCATGTCTATGTTTGGAACCTGCAAATAA TTTTTCAGTCATCTTAGAGATGCTGCAGAACATCAATGCCACATCTTGAGTCAGAAGTCGAGGGTCATTTGTTCAAAAGTTGGAGAAATATCCTCTTTTGTTGCTTCTTCTACTCTGTAGTGGAGAATGGGGAACTGGTAGTTGTGTGGG AGTTATGTGTCTCTAAGATTTGTCGACCCATTTTGATGGCAAGGTGTATTCACAAGTGTGTGTAAAGGGGGTGTGGATGGGACAACTGCATCTGCCTCTTGTGCATGCCTTGGGTACTTGATTTCATCTTGTTTTTTCCCCCTTTTGTAT AAAATTCTCAAAATTGCTCATTTGGATTTGAATATGAAAGGAGAAATGAAATCTCTAAAGAATGATAGTAAATACCTTGCACTGACTTTATTTTCTGATATCTTAACCTTCTAGGGCATAAAATCTTGTTATTTTAATTTGCATCTGGGA GAATGTCTGAGCAAGGAGACCTGAATCAGGCAATAGCAGAGGAAGGAGGGACTGAGCAGGAGACGGCCACTCCAGAGAACGGCATTGTTAAATCAGAAAGTCTGGATGAAGAGGAGAAACTGGAACTGCAGAGGCGGCTGGAGGCTCAGA ATCAAGAAAGAAGAAAATCCAAGTCAGGAGCAGGAAAAGGTAAACTGACTCGCAGCCTTGCTGTCTGTGAGGAATCTTCTGCCAGACCAGGAGGTGAAAGTCTTCAGGATCAG >ARPP21_FRMD4A_ENST00000444190_ENST00000493380_35725307_14125812 length=562nt Breakpoint=562nt AATGTTTATGCATAGAAATATAGCTGAGGTGGATGTGGTTGCTGTCAGCTATTCAGGTTTGCTACCTGATCACCTCCTGAAGATGTAGGGTTGACGATGTGTCACACTGTGTAAGGGAATCGCATGGAGATGGGCATTCCGAACTGTTAA TGGGGACATGGGACTCCAGTTGTCTCTGATCACTTGTGTGGATTTTCCTGGCGTAGAACGACAGAAGCCGCTAGTAAGTCGCCAAGACCTACAGCAGGAATTCTGCACCAAAGGGCATAAAATCTTGTTATTTTAATTTGCATCTGGGAG AATGTCTGAGCAAGGAGACCTGAATCAGGCAATAGCAGAGGAAGGAGGGACTGAGCAGGAGACGGCCACTCCAGAGAACGGCATTGTTAAATCAGAAAGTCTGGATGAAGAGGAGAAACTGGAACTGCAGAGGCGGCTGGAGGCTCAGAA TCAAGAAAGAAGAAAATCCAAGTCAGGAGCAGGAAAAGGTAAACTGACTCGCAGCCTTGCTGTCTGTGAGGAATCTTCTGCCAGACCAGGAGGTGAAAGTCTTCAGGATCAG >ARPP21_FRMD4A_ENST00000458225_ENST00000493380_35725307_14125812 length=486nt Breakpoint=486nt CAGTTCGATCAAGGTTGACGATGTGTCACACTGTGTAAGGGAATCGCATGGAGATGGGCATTCCGAACTGTTAATGGGGACATGGGACTCCAGTTGTCTCTGATCACTTGTGTGGATTTTCCTGGCGTAGAACGACAGAAGCCGCTAGTA AGTCGCCAAGACCTACAGCAGGAATTCTGCACCAAAGGGCATAAAATCTTGTTATTTTAATTTGCATCTGGGAGAATGTCTGAGCAAGGAGACCTGAATCAGGCAATAGCAGAGGAAGGAGGGACTGAGCAGGAGACGGCCACTCCAGAG AACGGCATTGTTAAATCAGAAAGTCTGGATGAAGAGGAGAAACTGGAACTGCAGAGGCGGCTGGAGGCTCAGAATCAAGAAAGAAGAAAATCCAAGTCAGGAGCAGGAAAAGGTAAACTGACTCGCAGCCTTGCTGTCTGTGAGGAATCT TCTGCCAGACCAGGAGGTGAAAGTCTTCAGGATCAG >ARPP21_FRMD4A_ENST00000474696_ENST00000493380_35725307_14125812 length=546nt Breakpoint=546nt CATTAGAGAAGAAGCAGGCAGCTTGAGACAGGTGGAGCTGGATCAAGCTGTGAACGTGATTTGCTGGAAGCTGGTTGACGATGTGTCACACTGTGTAAGGGAATCGCATGGAGATGGGCATTCCGAACTGTTAATGGGGACATGGGACTC CAGTTGTCTCTGATCACTTGTGTGGATTTTCCTGGCGTAGAACGACAGAAGCCGCTAGTAAGTCGCCAAGACCTACAGCAGGAATTCTGCACCAAAGGGCATAAAATCTTGTTATTTTAATTTGCATCTGGGAGAATGTCTGAGCAAGGA GACCTGAATCAGGCAATAGCAGAGGAAGGAGGGACTGAGCAGGAGACGGCCACTCCAGAGAACGGCATTGTTAAATCAGAAAGTCTGGATGAAGAGGAGAAACTGGAACTGCAGAGGCGGCTGGAGGCTCAGAATCAAGAAAGAAGAAAA TCCAAGTCAGGAGCAGGAAAAGGTAAACTGACTCGCAGCCTTGCTGTCTGTGAGGAATCTTCTGCCAGACCAGGAGGTGAAAGTCTTCAGGATCAG |
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Fusion Protein Sequence for ARPP21_FRMD4A |
| In-frame Fusion Protein Sequences. |
| N-Truncated Protein (5UTR-3CDS) Sequences |
| C-Truncated Protein (5CDS-3UTR) Sequences |
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Personalized Fusion Protein Sequence for ARPP21_FRMD4A |
| TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| TCGA All Mutated Fusion Protein Sequences |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
| CCLE All Mutated Fusion Protein Sequences |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
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Fusion Gene Exprssed Samples for ARPP21_FRMD4A |
| RNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB | LGG | TCGA-S9-A6U6-01A | ARPP21 | chr3 | 35725307 | + | FRMD4A | chr10 | 14125812 | - | |
| cBioPortal | LGG_TCGA_PAN_CAN_ATLAS_2018 | DIFG | TCGA-S9-A6U6-01 | ARPP21 | chr3 | 35683815 | FRMD4A | chr10 | 14083813 |
| DNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | SV type |
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Related Drugs for ARPP21_FRMD4A |
| PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug'] * For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub. |
| PMID | Fusion Gene Name | Drug | Study Title |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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