|
||||||
|
Fusion gene:ADAMTS7_PEAK1 (FusionGDB2 ID:HG11173TG79834) |
Fusion Gene Summary for ADAMTS7_PEAK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADAMTS7_PEAK1 | Fusion gene ID: hg11173tg79834 | Hgene | Tgene | Gene symbol | ADAMTS7 | PEAK1 | Gene ID | 11173 | 79834 |
| Gene name | ADAM metallopeptidase with thrombospondin type 1 motif 7 | pseudopodium enriched atypical kinase 1 | |
| Synonyms | ADAM-TS 7|ADAM-TS7|ADAMTS-7 | SGK269 | |
| Cytomap | 15q25.1 | 15q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | A disintegrin and metalloproteinase with thrombospondin motifs 7COMPasea disintegrin and metalloprotease with thrombospondin motifs-7 preproproteina disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7 | inactive tyrosine-protein kinase PEAK1NKF3 kinase family membersugen kinase 269tyrosine-protein kinase SgK269 | |
| Modification date | 20240407 | 20240407 | |
| UniProtAcc | Q9UKP4 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000388820, ENST00000566303, | ||
| Fusion gene scores | * DoF score | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 7 X 8 X 5=280 | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 6 X 9 X 10=540 |
| # samples | 52 | 14 | |
| ** MAII score | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(52/280*10)=0.893084796083488 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(14/540*10)=-1.94753258010586 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ADAMTS7 [Title/Abstract] AND PEAK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ADAMTS7(79080572)-PEAK1(77407661), # samples:1 | ||
| Fusion gene breakpoints across ADAMTS7 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across PEAK1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Fusion Gene Breakpoints for ADAMTS7_PEAK1 |
| RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ADAMTS7 | chr15 | 79080572 | PEAK1 | chr15 | 77407661 |
| ADAMTS7 | chr15 | 79080573 | PEAK1 | chr15 | 77407661 |
| ADAMTS7 | chr15 | 78788231 | PEAK1 | chr15 | 77115319 |
| DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | SV type |
Top |
Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for ADAMTS7_PEAK1 |
| To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence. |
| Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions | Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity | Epigenetic Reprogramming / Histone Modifier Dysregulation | Chromatin Remodeling Dysregulation | Condensate-Driven Transcriptional Rewiring / LLP | Promoter / Enhancer Hijacking | Dominant-Negative Antagonism | Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation | Subcellular Mislocalization / Spatial Dysregulation | Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade |  |  |  |  |  |  |  |  |  |  |
* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
| ADAMTS7-PEAK1 | Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions M1 | ADAMTS7 sequence fused to PEAK1 pseudo/tyrosine kinase scaffold drives constitutive Grb2/Src association and MEK/ERK activation. | Src family kinase inhibitors (dasatinib); MEK inhibitors | Pancreatic ductal adenocarcinoma and colon cancer |
* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
| ADAMTS7-PEAK1 | Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions M1 | Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 34944965; Title: SHED-Dependent Oncogenic Signaling of the PEAK3 Pseudo-Kinase. | ADAMTS7 sequence fused to PEAK1 pseudo/tyrosine kinase scaffold drives constitutive Grb2/Src association and MEK/ERK activation. | Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 34944965; Title: SHED-Dependent Oncogenic Signaling of the PEAK3 Pseudo-Kinase.; PMID: 40707483; Title: PEAK1 maintains tight junctions in intestinal epithelial cells and resists colitis by inhibiting autophagy-mediated ZO-1 degradation. | Src family kinase inhibitors (dasatinib); MEK inhibitors | Pancreatic ductal adenocarcinoma and colon cancer | Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 34479583; Title: Importance of Circ0009910 in colorectal cancer pathogenesis as a possible regulator of miR-145 and PEAK1. |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ADAMTS7 | . |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ADAMTS7 | GO:0032331 | negative regulation of chondrocyte differentiation | 22247065 |
| Hgene | ADAMTS7 | GO:0071773 | cellular response to BMP stimulus | 22247065 |
| Tgene | PEAK1 | GO:0016477 | cell migration | 20534451 |
| Tgene | PEAK1 | GO:0034446 | substrate adhesion-dependent cell spreading | 20534451 |
| Tgene | PEAK1 | GO:0046777 | protein autophosphorylation | 20534451 |
| Tgene | PEAK1 | GO:0051893 | regulation of focal adhesion assembly | 23105102 |
Top |
Fusion Genomic Features for ADAMTS7_PEAK1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| ADAMTS7 | chr15 | 79080572 | - | PEAK1 | chr15 | 77407661 | - | 1.26e-04 | 1.00e+00 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| ADAMTS7 | chr15 | 79080572 | - | PEAK1 | chr15 | 77407661 | - | 1.26e-04 | 1.00e+00 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF). |
 |
Top |
Fusion Gene ORF Annotations for ADAMTS7_PEAK1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000566303 | ENST00000560626 | ADAMTS7 | chr15 | 79080572 | - | PEAK1 | chr15 | 77407661 | - |
| In-frame | ENST00000388820 | ENST00000560626 | ADAMTS7 | chr15 | 79080572 | - | PEAK1 | chr15 | 77407661 | - |
| ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ENST00000388820 | ENST00000560626 | ADAMTS7 | chr15 | 79080572 | PEAK1 | chr15 | 77407661 | 1533 | 441 |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ENST00000566303 | ENST00000560626 | ADAMTS7 | chr15 | 79080572 | PEAK1 | chr15 | 77407661 | 0 | 302 |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| ENST00000388820 | ENST00000560626 | ADAMTS7 | chr15 | 79080572 | PEAK1 | chr15 | 77407661 | 3.10e-03 | 9.97e-01 |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| ENST00000566303 | ENST00000560626 | ADAMTS7 | chr15 | 79080572 | PEAK1 | chr15 | 77407661 | 0.00e+00 | 3.85e-02 |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
Top |
Fusion Protein Retained/Non-Retained Functional Features for ADAMTS7_PEAK1 |
| Protein Level Annotation from FGviewer * Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS. |
 |
| - In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length). |
| No matching images found for ${hg}_${tg}. |
| - In-frame and retained protein feature among the 13 regional features (texts). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ADAMTS7 | chr15:79080572 | chr15:77407661 | ENST00000388820 | Q9UKP4 | 8 | 24 | 202_209 | 440.6666666666667 | 1687.0 | Motif | Cysteine switch |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ADAMTS7 | chr15:79080572 | chr15:77407661 | ENST00000388820 | Q9UKP4 | 8 | 24 | 1182_1205 | 440.6666666666667 | 1687.0 | Compositional bias | Polar residues |
| Hgene | ADAMTS7 | chr15:79080572 | chr15:77407661 | ENST00000388820 | Q9UKP4 | 8 | 24 | 1210_1226 | 440.6666666666667 | 1687.0 | Compositional bias | Basic and acidic residues |
| Hgene | ADAMTS7 | chr15:79080572 | chr15:77407661 | ENST00000388820 | Q9UKP4 | 8 | 24 | 1360_1375 | 440.6666666666667 | 1687.0 | Compositional bias | Low complexity |
| Hgene | ADAMTS7 | chr15:79080572 | chr15:77407661 | ENST00000388820 | Q9UKP4 | 8 | 24 | 1411_1459 | 440.6666666666667 | 1687.0 | Domain | TSP type-1 5 |
| Hgene | ADAMTS7 | chr15:79080572 | chr15:77407661 | ENST00000388820 | Q9UKP4 | 8 | 24 | 1462_1522 | 440.6666666666667 | 1687.0 | Domain | TSP type-1 6 |
| Hgene | ADAMTS7 | chr15:79080572 | chr15:77407661 | ENST00000388820 | Q9UKP4 | 8 | 24 | 1523_1567 | 440.6666666666667 | 1687.0 | Domain | TSP type-1 7 |
| Hgene | ADAMTS7 | chr15:79080572 | chr15:77407661 | ENST00000388820 | Q9UKP4 | 8 | 24 | 1569_1629 | 440.6666666666667 | 1687.0 | Domain | TSP type-1 8 |
| Hgene | ADAMTS7 | chr15:79080572 | chr15:77407661 | ENST00000388820 | Q9UKP4 | 8 | 24 | 1632_1672 | 440.6666666666667 | 1687.0 | Domain | PLAC |
| Hgene | ADAMTS7 | chr15:79080572 | chr15:77407661 | ENST00000388820 | Q9UKP4 | 8 | 24 | 242_452 | 440.6666666666667 | 1687.0 | Domain | Peptidase M12B |
| Hgene | ADAMTS7 | chr15:79080572 | chr15:77407661 | ENST00000388820 | Q9UKP4 | 8 | 24 | 462_537 | 440.6666666666667 | 1687.0 | Domain | Note=Disintegrin |
| Hgene | ADAMTS7 | chr15:79080572 | chr15:77407661 | ENST00000388820 | Q9UKP4 | 8 | 24 | 538_593 | 440.6666666666667 | 1687.0 | Domain | TSP type-1 1 |
| Hgene | ADAMTS7 | chr15:79080572 | chr15:77407661 | ENST00000388820 | Q9UKP4 | 8 | 24 | 821_880 | 440.6666666666667 | 1687.0 | Domain | TSP type-1 2 |
| Hgene | ADAMTS7 | chr15:79080572 | chr15:77407661 | ENST00000388820 | Q9UKP4 | 8 | 24 | 881_940 | 440.6666666666667 | 1687.0 | Domain | TSP type-1 3 |
| Hgene | ADAMTS7 | chr15:79080572 | chr15:77407661 | ENST00000388820 | Q9UKP4 | 8 | 24 | 942_995 | 440.6666666666667 | 1687.0 | Domain | TSP type-1 4 |
| Hgene | ADAMTS7 | chr15:79080572 | chr15:77407661 | ENST00000388820 | Q9UKP4 | 8 | 24 | 1024_1043 | 440.6666666666667 | 1687.0 | Region | Disordered |
| Hgene | ADAMTS7 | chr15:79080572 | chr15:77407661 | ENST00000388820 | Q9UKP4 | 8 | 24 | 1080_1257 | 440.6666666666667 | 1687.0 | Region | Disordered |
| Hgene | ADAMTS7 | chr15:79080572 | chr15:77407661 | ENST00000388820 | Q9UKP4 | 8 | 24 | 1344_1396 | 440.6666666666667 | 1687.0 | Region | Disordered |
| Hgene | ADAMTS7 | chr15:79080572 | chr15:77407661 | ENST00000388820 | Q9UKP4 | 8 | 24 | 1666_1686 | 440.6666666666667 | 1687.0 | Region | Disordered |
| Hgene | ADAMTS7 | chr15:79080572 | chr15:77407661 | ENST00000388820 | Q9UKP4 | 8 | 24 | 698_809 | 440.6666666666667 | 1687.0 | Region | Note=Spacer |
| - Retained PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Fusion Transcript Sequence for ADAMTS7_PEAK1 |
| In-frame Fusion Transcript Sequences. |
>ADAMTS7_PEAK1_ENST00000388820_ENST00000560626_79080572_77407661 length=8695nt Breakpoint=1533nt CTTTTCTTTGCCTCTGCAGCGGCCAAGGGGGCGGGCCCTGCAGCCTTTGTTGCCCGCGGACCGAGCGCAGCCGAACGGAGTCGGGGCCGGGTCGCCGGGAGCTGCACGCCGGCCGGGCATGTCCTGAGCCGGACCTGGGACCAGGCAGCG ACCGGACGGGACGGACGAGAGCGTGCGCGCGGGGTCACCCGGCGGCCGCCCGGTTCCTGCCATGCCCGGCGGCCCCAGTCCCCGCAGCCCCGCGCCTTTGCTGCGCCCCCTCCTCCTGCTCCTCTGCGCTCTGGCTCCCGGCGCCCCCGG ACCCGCACCAGGACGTGCAACCGAGGGCCGGGCGGCACTGGACATCGTGCACCCGGTTCGAGTCGACGCGGGGGGCTCCTTCCTGTCCTACGAGCTGTGGCCCCGCGCACTGCGCAAGCGGGATGTATCTGTGCGCCGAGACGCGCCCGC CTTCTACGAGCTACAATACCGCGGGCGCGAGCTGCGCTTCAACCTGACCGCCAATCAGCACCTGCTGGCGCCCGGCTTTGTGAGCGAGACGCGGCGGCGCGGCGGCCTGGGCCGCGCGCACATCCGGGCCCACACCCCGGCCTGCCACCT GCTTGGCGAGGTGCAGGACCCTGAGCTCGAGGGTGGCCTGGCGGCCATCAGCGCCTGCGACGGCCTGAAAGGTGTGTTCCAGCTCTCCAACGAGGACTACTTCATTGAGCCCCTGGACAGTGCCCCGGCCCGGCCTGGCCACGCCCAGCC CCATGTGGTGTACAAGCGTCAGGCCCCGGAGAGGCTGGCACAGCGGGGTGATTCCAGTGCTCCAAGCACCTGTGGAGTGCAAGTGTACCCAGAGCTGGAGTCTCGACGGGAGCGTTGGGAGCAGCGGCAGCAGTGGCGGCGGCCACGGCT GAGGCGTCTACACCAGCGGTCGGTCAGCAAAGAGAAGTGGGTGGAGACCCTGGTAGTAGCTGATGCCAAAATGGTGGAGTACCACGGACAGCCGCAGGTTGAGAGCTATGTGCTGACCATCATGAACATGGTGGCTGGCCTGTTTCATGA CCCCAGCATTGGGAACCCCATCCACATCACCATTGTGCGCCTGGTCCTGCTGGAAGATGAGGAGGAGGACCTAAAGATCACGCACCATGCAGACAACACCCTGAAGAGCTTCTGCAAGTGGCAGAAAAGCATCAACATGAAGGGGGATGC CCATCCCCTGCACCATGACACTGCCATCCTGCTCACCAGAAAGGACCTGTGTGCAGCCATGAACCGGCCCTGTGAGACCCTGGGACTGTCCCATGTGGCGGGCATGTGCCAGCCGCACCGCAGCTGCAGCATCAACGAGGACACGGGCCT GCCGCTGGCCTTCACTGTAGCCCACGAGCTCGGGCACAGTTTTGGCATTCAGCATGACGGAAGCGGCAATGACTGTGAGCCCGTTGGGAAACGACCTTTCATCATGTCTCCACAGCTCCTGTACGACGCCGCTCCCCTCACCTGGTCCCG CTGCAGCCGCCAGTATATCACCAGGTTCCTTGAATCTGTAAGAGCAAAGCTAAAGAATCTCAGCAGTATTATCACAGCTTGGCTGTCCGGCAGAGTCTGGCTGTCCATTTTAACATTCAGCAGGACTGTGGTCATTTCCTTGCTGAAGTC CCTAACCGTCTGCTTCCCTGGGAGGATCCAGATGACCCTGAAAAGGATGAGGATGACATGGAAGAGACTGAAGAAGACGCCAAAGGAGAAACGGATGGGAAAAACCCAAAGCCCTGTTCTGAAGCAGCATCATCCCAGAAAGAGAATCAG GGAGTCATGAGCAAGAAGCAGAGGAGCCACGTTGTGGTCATCACCAGGGAGGTTCCATGTCTTACTGTGGCTGATTTTGTGCGAGACTCTCTGGCCCAGCATGGGAAAAGCCCTGATTTGTATGAGAGGCAGGTGTGTCTGCTGCTCTTA CAGCTATGCTCTGGTCTTGAGCACCTCAAACCCTACCATGTCACTCACTGCGATCTACGCCTAGAGAACCTGCTACTTGTCCACTACCAGCCTGGGGGGACTGCCCAAGGCTTTGGGCCTGCAGAGCCCAGCCCCACCTCATCTTATCCC ACTAGGCTTATAGTGAGCAACTTCTCTCAGGCCAAGCAGAAGAGCCATCTGGTGGACCCCGAGATCCTCCGGGACCAGTCTCGCCTTGCCCCAGAGATCATAACAGCTACCCAGTATAAAAAGTGTGATGAGTTCCAGACAGGCATCCTC ATCTATGAGATGCTGCACCTACCCAACCCCTTTGATGAGAACCCAGAGCTGAAGGAGAGGGAATACACACGAGCAGACCTGCCTCGCATCCCATTCCGCTCCCCCTACTCCCGGGGTCTGCAGCAGCTGGCCAGCTGCCTCCTGAATCCC AACCCTTCTGAGCGGATCCTCATTTCAGACGCCAAAGGCATCCTCCAGTGTCTGCTCTGGGGCCCCCGCGAAGATCTCTTCCAGACTTTCACCGCCTGCCCTAGCCTAGTACAGAGGAACACCCTGCTCCAAAACTGGCTAGACATCAAG CGAACACTGCTCATGATCAAGTTTGCTGAGAAGTCCCTGGACAGGGAAGGTGGAATCAGCCTTGAGGACTGGCTTTGTGCTCAGTATTTGGCTTTTGCCACTACAGACTCCCTCAGTTGTATTGTGAAAATTCTGCAGCACCGTTAATGT GTACCTGGATGATGCTTTTACTACATCTTCACCTTCTTCATGTCACCCATGCACTTCCCCTCCCTAGTGCTCACTCCAAATTCAAGGAAAGAAGAAAGGCAAACCTCTATCCCTGTCCGTGAACAAGTGGGTCTATTCAGAAAGGTTATC CACTGCCCCAGATTGAATGAGAAGCTGAGTCTGTCTTAACTTTACAGAAATTCAGCTGCACAAACTTGCAGTTGCCTTCCCTTGAAACACCTTCTATCCTAATAGTCCCATAAATGCAGGTAAAAATGAAAATCCATATTCTTGAAGGGA CAGCTTCTTTGGTATGAACTCAGCCAGTGAGCTGTGTCCATTTCCTCCATAATTCTGGATATCACCTATCTTTTTAGCACCAAGTATTTATTCTCACTAGCAGTAGACAGACTTAACCAGTCTCTACCACGACCCAGTAGACTCTGACAA CAGACTCTTCCTTTAAGGTGTCAACAACTGACTTACTAGGCAGGACTGCCATCCTTAGCATCAGCCCAGTTTTGGTTACCAGGGACTATATCTTTTGTTCCAGGAGAGAGTAGAAAGAAAAGGAGAGATCCCATCCTTGGGTCATAGACC CATTTTCATTGCCATTATCTGTAAGTATGTGCACTGCATGGAGGACAGCCCTAATAGTCTCCCCTCTGCTGCCACTGCCTGATTCTCCACTCTGTCCCCACTTGCCAGTGAAGTTTGGATTTATCAGCCACTTGTGGCCCATTACAGAGC TGACCCAAGGTGGTGTCACCAATGCCTCAGCAGGGTGGAGTGCAGTTCAGAGCTTATAAATAGCTGGCAGGGCATGAGGAGATGATTTTCTTGCATGTGCAATTCTCTAGGGGCCATCAGGAAACAGAGTTTAAAGTACCCTTTGATTAC TGTCAGAACTGTCAGCATTTGCAGTTTTCCCCGAGCAGTAATTGGCCAGCTCCCTTCTATCAGTAGCCAGTGTTAACTAGTTTACCAAATGCTGTAAACAATTGCCCTGAATGAAATAGCTGTCAGTGGAGCTCTAAGATCTCCTTTAGA GGGCACAGTGAGGTGGGCTGTTGGGATGGCCGTAGGCAGGGGAGAGGAAGAAGGCCACTGATGAGACTGCTGACCTCCTCAGAAGGTTGACCTCTTCTAGAGAGACTGCCTCCCAGTGTTTAAGTGGCTCATTGCTCCTTCTGACTCTGT AAAATGGCTCTGGAGGACAGCTCACAGGAATTCTGATTGCTGAGGTGGGTGATTGAGAGCTGTTCACCATGTGTGCAGCCTGTGCTCCCCTTCTATGGATATGTGTGCAATTTTTGTATGTATTTTTTTAGCTGTATATTACAGTGTTTA TGTTGCAACTTCACCTGAAGCGAGTCTACAGAAACCCTCCCCCTTCTTCCCTTGGCACATATTTGCGCTAAGAGATGAGCGTTCCTTCCACTGGGGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTATAC ACATGTTCACCTGTGCTTGTTTTATTCAAAACTGTGAGTATGTGTTTACTTTGACCTTGAAATCCCAAGAGTCACTCGAACAATGTGTGTGTACACTTGTGTGCCCATGTGTGCGTGCACACGCATGCTGGAAGTAGAGGCCAGGCCTCT AGAAAAGCAACCTGTGGCAGGGTTGACAGACATGTTCTCTGTGCCTAGTGAGTGAGTGAGCCCTGAGGCCCCTCATCTACCAGTGCAGAGTTTCCTTAAAGCCAAGACTGACTGTGCAGTATTACTTACATAGCACATTAGTGGCCTTGG AAATTTCTAAACTTTTAACATTTTTAACAGCTTTTCATGTGATTCATGTATAACAAAGAGGATCAGGAAAGGAAAATAATGTATTTTATTGTGCTCTTATTACTTTTTTAAGTGATTGTAATATGTGAGGCTCTATTTGGAGAATGTCCC TTATCCCCTGGCCAGCAATATAGGACTCACAGGAAAGAAGGCTGGTTAGCCCACAAAGAGTCTTGCCTCCTCTAGCCAGAGTGCAGGGCTCTGCTCCTAGGAATGGCCATGGAGTGGGCATGCTGCTGCAGGCCAGCAGTCTGCTCTTGG TGTCCTGTGGCATGGCCGCGCCTTGCCTTGAAGGTTGGTGTTTGGTTCATCTTAGCATAGAACATGTGCACATAACTCCTTGCCTGATTATGCACTGAAGGGCAGCACACAGACCACTGACCATGTCAGCCAGCACATTCCCTTAACCTC CCCCACCTCCCATCTTGCAATGTCTTGCATATTGAGATATACCTTCTCAATGTCATGTTCGTGGTGCCTTGCCCATGTAAATTTCAATGTTGACTATTTAATGAGGTTACATATTTAATGCTGAATGTTTCCTGGTCCCTCTATTTGTTA TGTCTCTACTTATCTTTTTTTTTCTTTCTCTTTTTCTGTTATGATTTGGATCCAGTCTTCACTTTAACTCTATGGTATAATAAGCATGGACACCTCCACTACCATTATCTTACAGCACTGGTAAACCAAGCACCTCTTCATATCAGATGT TTTTAGTACTGTTTTTATATTCAGATTTGTTAAGGGCAAAAGATGAATGCAAACTAGCCAGAGAAAAGCCTCAGGCTTCCCAGAGACAGGTGGCTAGATTAATTTTTCTCTGGGTGATGGCCAAAGAATGTGAGATAGAGAGGGAAGGGG GTGTTACAGGTTAGAGCAGAATAGAGAAAGAAACTATATTTCTAGGCAAAAAGTACTACATGAGTTGGTCTTCAGAATATTTTTCCAAAAAAATGAAATTCAGTCAGTTTAACATTATCACAAATATTTTTCATTTTAATTGTGGTAGGA CCTTTGAATTTGTTCATCAACTGGAAAGAAATCCTACCCTCTGTAGACACATACACACACATTTATATATCTATGTGTTTGAATTGTGACTAGTATAGCACTTTACATTTTCTCAAGTAACAGGAAGTTATTGCCTTCAATATTGATTGG AAATTGTTTTCTATTGAAGTCTATACTGTAGAGTTTTCCATTTATATTGAGAGTTTGAACAATTAAGCTCCTATTGGAACTTTTCCTTAAGCCACATGAGCATGAACAATCTCTGTGACACTTGGGTGCTAGAGAAACACAACAGTGGCT AAAGTAGCCAAGAGCAAGACTGAATGTATAGCAGAGTGCCTTGTTAGAGTGGTAACCTAGTCTTGGAAGCAATTCAGTGGATGTTTCATAAAGAGGACTAGAACTTCAAGAAGCCTCCTGTGCTGGCTGAGGTGAGCCCTTTTGGTATAT GTACACTACTGGGTTGCCTAGAAGCCAATTCATGAAGAATAACAGCAGGATGAGAAAAAGAGTCACTGTAACCTGTGGAACAACAACGTAAGAATCACCAACCCCTAGGCTGAGCTAGAACTGGAAGCCAGGAATATGGCAATGAGTTTC AAGATTTGCCCTCAGAAGATGAACTGGGTGAGGTATGGGTTGAGGTGAGGGCACAAGCACTCATCCTACCTACCCTGCTGCTGTTGAGGAGCTAGAAGTAAAACATATTGGTTAGGATTTTAACAGTTGGAGTAGCCTCCCATTATCAGA TTAAGTGGGGGTCACTTTTGCTTCCAAACTCAGAATAAGTTTGTAAACATGGGAAAGTCTAAGCCAAGAGATCTAAAGCTCTAGAAATATTAATGACATTTCTGGGAGTAAAACTACTAAAAATTATATCTTAAAAGTTTCTAGTAGTAT GAAGTTCCCAGGCCAGGCGCAGTGGCTCACGCCTGTAATCCCAACACTTTAGGAGGGCGAGGTGGGCAGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACTCCATCTCTACTAAAAATACAAAAATTAGCCG GGCATGATGGCAGGCACCTGTAATCTAAGCTACTCGGGAGGCTGAGGCAAGAGAATCTCTTGAACCCAGGAGGCAAAGGTTGCAGTGAGCCAAGATCACGCCATCGCACTCCAGCCTGGGAGATTGAGCAACTTCGTCTCAAAAAAAAGT TTCCAGGAAAGATCTTTGGGTCCTACTAAGCGTCTCAATTTTGAGTTATGAATACTTTGGTTCAGGGAAGTAACCTGACATTTGGTTTTGCTGGAATTAGGGTTTTCGCTAGATTTGACTGCAATTAGGATTTCTTCTAGATTTTACCAG CAGTGATCTGAAAAAGTACAGGCTAGTCACAGAAATAGAGATGGATTTAGGATACTACACTATATTTCAAATGATTCTAGATGTGTAAATATAGTATGAACATTCTTGGAGAGGGGTGAGACAAACTGGACTTGCTGGGCCAACCCTGGC ATGTTTTTCATTCTCCTCACTAGTTGACAAGGATTGAAAATTCCGCTCCAGCCTAATGAGTGAACAGGATGGCTGCCCACAAAACCAAGTTATTAGCTTTATGTCATCGAAGCTCATATTCTCAAAGGCCCAAAGTGCTGTGCCGAGACA AATCCAAGTGCTGCTCTTGCTGAAGTGCGCACTGAAGTCCAGCTGTCCGTGCTTACAGCAGTGCCAAAAGTGGGGATTCCATGGACCAAAAACGGTGCCATAAGGGAAGCCAGAAGAGTTGCAGTGCAAGATCCTGGGAGAGATTATACC AAAGAAATCAAGCCTTTTTATCCTGATGCTTCTAAGATGATGAGGGTGAGCTGTGACAGATGCTGTGGGAGGGGAGTTCACATACATTCCATGTCAAGGCATTTAGCTGATAAATCCATCCTCAGAAAAGCACCTTTTTAAAAAGAAGTC CATTTTGTATATTAGAAGATGATGATGATGATGAAGATGAAGAAAGCCCTGGCAGATACAAAGTTCCTCAGTATTTAAGGAGAAGGATCTCTTCCATGTCCCCTTGACATGACTGTGGCTATTGCCCAAACCTCAGCTTGAGAACATCAT ATAATACTGAGAGCGGAAGATTTTTTTAAAGAGATATGGTAGTTTAAATAGGTTTGTTTAAAGAACTCTTGGGAAATTTCTTAACAAATTGTAATTGTTTTTATAAACCTTCCTACAGAGTTGTGTACCATTCATCATCACCATCATTTA ATATCTGTAAGTGCCCAGAAGGTACAAGGTGCTATACAGCCGTTAAACACCCCCTCCCTGCAACTGTTTAAAATTAGAATAGATTTTTGCATCAACCACTGCTAGAAGCTTTCCCCACCTAGGTGGGCTGCAAGGGCCTGCATTCCCAAC ATCCCATTACATGTTTCCCACTCCAGAAAGTCTCTGGGTTTATTCCAGCTTTTTATCTTGACGTGTCCCATTCACCCCCATGGTTTGGTTTGGTTTGGTTTTGTTTTTTAAATCAAGAAAGTTTCAGGGAATCAAAAGAGGTCGGACATT TTTTAACCTAGCAGAAGTACAGAGTCATATATTTTGCTACGAATATTGTTGTAGTACAGAAAACCCACTTTGCCCGTTAGTGTGTGGATAGTATGTGTGTGTCCGCACTCATGATAACTTGAATGTTGAACCAGACATAGGGTTCATTTT TGAAAGGTTAAACCACACTGTTTCAGGAACTTGCTCCAAATACTACTTGGTTATCCCTTCCTTTACCAGTTAGAACTAAAGAGTGTGATGTATGAACACACTGGGTTGGGATTTTCTGTTGAGGATATGCAGGGCATTTTGGCATGAGGC AAATACAGAAGCAAGATTTCATTCTACTTGGTGATTTGAATCATGACAGTCCTCATTCCAATCTCTCTTTAATTCTCTCTGGCCCTGCCCACACTCTGTATTTGAAAATCTTGTTTTTGCTCTTTCCGGAGCTTCACCCCTCTACTTACA TATTGTAAAGTTGTATAAATCTATCATTGAAAGGTCCTCTCTGCCAGCAGTGGTGCCACCCTTTGGTTTGCTGTGGTACTTTGCTGTGTACTCCGTGGCATCATGTTACTGTGTAAATAAATTCATTTTAATACACACTAAAAAA |
| N-Truncated Transcript (5UTR-3CDS) Sequences |
>ADAMTS7_PEAK1_ENST00000566303_ENST00000560626_79080572_77407661 length=7162nt Breakpoint=0nt ATCTGTAAGAGCAAAGCTAAAGAATCTCAGCAGTATTATCACAGCTTGGCTGTCCGGCAGAGTCTGGCTGTCCATTTTAACATTCAGCAGGACTGTGGTCATTTCCTTGCTGAAGTCCCTAACCGTCTGCTTCCCTGGGAGGATCCAGAT GACCCTGAAAAGGATGAGGATGACATGGAAGAGACTGAAGAAGACGCCAAAGGAGAAACGGATGGGAAAAACCCAAAGCCCTGTTCTGAAGCAGCATCATCCCAGAAAGAGAATCAGGGAGTCATGAGCAAGAAGCAGAGGAGCCACGTT GTGGTCATCACCAGGGAGGTTCCATGTCTTACTGTGGCTGATTTTGTGCGAGACTCTCTGGCCCAGCATGGGAAAAGCCCTGATTTGTATGAGAGGCAGGTGTGTCTGCTGCTCTTACAGCTATGCTCTGGTCTTGAGCACCTCAAACCC TACCATGTCACTCACTGCGATCTACGCCTAGAGAACCTGCTACTTGTCCACTACCAGCCTGGGGGGACTGCCCAAGGCTTTGGGCCTGCAGAGCCCAGCCCCACCTCATCTTATCCCACTAGGCTTATAGTGAGCAACTTCTCTCAGGCC AAGCAGAAGAGCCATCTGGTGGACCCCGAGATCCTCCGGGACCAGTCTCGCCTTGCCCCAGAGATCATAACAGCTACCCAGTATAAAAAGTGTGATGAGTTCCAGACAGGCATCCTCATCTATGAGATGCTGCACCTACCCAACCCCTTT GATGAGAACCCAGAGCTGAAGGAGAGGGAATACACACGAGCAGACCTGCCTCGCATCCCATTCCGCTCCCCCTACTCCCGGGGTCTGCAGCAGCTGGCCAGCTGCCTCCTGAATCCCAACCCTTCTGAGCGGATCCTCATTTCAGACGCC AAAGGCATCCTCCAGTGTCTGCTCTGGGGCCCCCGCGAAGATCTCTTCCAGACTTTCACCGCCTGCCCTAGCCTAGTACAGAGGAACACCCTGCTCCAAAACTGGCTAGACATCAAGCGAACACTGCTCATGATCAAGTTTGCTGAGAAG TCCCTGGACAGGGAAGGTGGAATCAGCCTTGAGGACTGGCTTTGTGCTCAGTATTTGGCTTTTGCCACTACAGACTCCCTCAGTTGTATTGTGAAAATTCTGCAGCACCGTTAATGTGTACCTGGATGATGCTTTTACTACATCTTCACC TTCTTCATGTCACCCATGCACTTCCCCTCCCTAGTGCTCACTCCAAATTCAAGGAAAGAAGAAAGGCAAACCTCTATCCCTGTCCGTGAACAAGTGGGTCTATTCAGAAAGGTTATCCACTGCCCCAGATTGAATGAGAAGCTGAGTCTG TCTTAACTTTACAGAAATTCAGCTGCACAAACTTGCAGTTGCCTTCCCTTGAAACACCTTCTATCCTAATAGTCCCATAAATGCAGGTAAAAATGAAAATCCATATTCTTGAAGGGACAGCTTCTTTGGTATGAACTCAGCCAGTGAGCT GTGTCCATTTCCTCCATAATTCTGGATATCACCTATCTTTTTAGCACCAAGTATTTATTCTCACTAGCAGTAGACAGACTTAACCAGTCTCTACCACGACCCAGTAGACTCTGACAACAGACTCTTCCTTTAAGGTGTCAACAACTGACT TACTAGGCAGGACTGCCATCCTTAGCATCAGCCCAGTTTTGGTTACCAGGGACTATATCTTTTGTTCCAGGAGAGAGTAGAAAGAAAAGGAGAGATCCCATCCTTGGGTCATAGACCCATTTTCATTGCCATTATCTGTAAGTATGTGCA CTGCATGGAGGACAGCCCTAATAGTCTCCCCTCTGCTGCCACTGCCTGATTCTCCACTCTGTCCCCACTTGCCAGTGAAGTTTGGATTTATCAGCCACTTGTGGCCCATTACAGAGCTGACCCAAGGTGGTGTCACCAATGCCTCAGCAG GGTGGAGTGCAGTTCAGAGCTTATAAATAGCTGGCAGGGCATGAGGAGATGATTTTCTTGCATGTGCAATTCTCTAGGGGCCATCAGGAAACAGAGTTTAAAGTACCCTTTGATTACTGTCAGAACTGTCAGCATTTGCAGTTTTCCCCG AGCAGTAATTGGCCAGCTCCCTTCTATCAGTAGCCAGTGTTAACTAGTTTACCAAATGCTGTAAACAATTGCCCTGAATGAAATAGCTGTCAGTGGAGCTCTAAGATCTCCTTTAGAGGGCACAGTGAGGTGGGCTGTTGGGATGGCCGT AGGCAGGGGAGAGGAAGAAGGCCACTGATGAGACTGCTGACCTCCTCAGAAGGTTGACCTCTTCTAGAGAGACTGCCTCCCAGTGTTTAAGTGGCTCATTGCTCCTTCTGACTCTGTAAAATGGCTCTGGAGGACAGCTCACAGGAATTC TGATTGCTGAGGTGGGTGATTGAGAGCTGTTCACCATGTGTGCAGCCTGTGCTCCCCTTCTATGGATATGTGTGCAATTTTTGTATGTATTTTTTTAGCTGTATATTACAGTGTTTATGTTGCAACTTCACCTGAAGCGAGTCTACAGAA ACCCTCCCCCTTCTTCCCTTGGCACATATTTGCGCTAAGAGATGAGCGTTCCTTCCACTGGGGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTATACACATGTTCACCTGTGCTTGTTTTATTCAAAACT GTGAGTATGTGTTTACTTTGACCTTGAAATCCCAAGAGTCACTCGAACAATGTGTGTGTACACTTGTGTGCCCATGTGTGCGTGCACACGCATGCTGGAAGTAGAGGCCAGGCCTCTAGAAAAGCAACCTGTGGCAGGGTTGACAGACAT GTTCTCTGTGCCTAGTGAGTGAGTGAGCCCTGAGGCCCCTCATCTACCAGTGCAGAGTTTCCTTAAAGCCAAGACTGACTGTGCAGTATTACTTACATAGCACATTAGTGGCCTTGGAAATTTCTAAACTTTTAACATTTTTAACAGCTT TTCATGTGATTCATGTATAACAAAGAGGATCAGGAAAGGAAAATAATGTATTTTATTGTGCTCTTATTACTTTTTTAAGTGATTGTAATATGTGAGGCTCTATTTGGAGAATGTCCCTTATCCCCTGGCCAGCAATATAGGACTCACAGG AAAGAAGGCTGGTTAGCCCACAAAGAGTCTTGCCTCCTCTAGCCAGAGTGCAGGGCTCTGCTCCTAGGAATGGCCATGGAGTGGGCATGCTGCTGCAGGCCAGCAGTCTGCTCTTGGTGTCCTGTGGCATGGCCGCGCCTTGCCTTGAAG GTTGGTGTTTGGTTCATCTTAGCATAGAACATGTGCACATAACTCCTTGCCTGATTATGCACTGAAGGGCAGCACACAGACCACTGACCATGTCAGCCAGCACATTCCCTTAACCTCCCCCACCTCCCATCTTGCAATGTCTTGCATATT GAGATATACCTTCTCAATGTCATGTTCGTGGTGCCTTGCCCATGTAAATTTCAATGTTGACTATTTAATGAGGTTACATATTTAATGCTGAATGTTTCCTGGTCCCTCTATTTGTTATGTCTCTACTTATCTTTTTTTTTCTTTCTCTTT TTCTGTTATGATTTGGATCCAGTCTTCACTTTAACTCTATGGTATAATAAGCATGGACACCTCCACTACCATTATCTTACAGCACTGGTAAACCAAGCACCTCTTCATATCAGATGTTTTTAGTACTGTTTTTATATTCAGATTTGTTAA GGGCAAAAGATGAATGCAAACTAGCCAGAGAAAAGCCTCAGGCTTCCCAGAGACAGGTGGCTAGATTAATTTTTCTCTGGGTGATGGCCAAAGAATGTGAGATAGAGAGGGAAGGGGGTGTTACAGGTTAGAGCAGAATAGAGAAAGAAA CTATATTTCTAGGCAAAAAGTACTACATGAGTTGGTCTTCAGAATATTTTTCCAAAAAAATGAAATTCAGTCAGTTTAACATTATCACAAATATTTTTCATTTTAATTGTGGTAGGACCTTTGAATTTGTTCATCAACTGGAAAGAAATC CTACCCTCTGTAGACACATACACACACATTTATATATCTATGTGTTTGAATTGTGACTAGTATAGCACTTTACATTTTCTCAAGTAACAGGAAGTTATTGCCTTCAATATTGATTGGAAATTGTTTTCTATTGAAGTCTATACTGTAGAG TTTTCCATTTATATTGAGAGTTTGAACAATTAAGCTCCTATTGGAACTTTTCCTTAAGCCACATGAGCATGAACAATCTCTGTGACACTTGGGTGCTAGAGAAACACAACAGTGGCTAAAGTAGCCAAGAGCAAGACTGAATGTATAGCA GAGTGCCTTGTTAGAGTGGTAACCTAGTCTTGGAAGCAATTCAGTGGATGTTTCATAAAGAGGACTAGAACTTCAAGAAGCCTCCTGTGCTGGCTGAGGTGAGCCCTTTTGGTATATGTACACTACTGGGTTGCCTAGAAGCCAATTCAT GAAGAATAACAGCAGGATGAGAAAAAGAGTCACTGTAACCTGTGGAACAACAACGTAAGAATCACCAACCCCTAGGCTGAGCTAGAACTGGAAGCCAGGAATATGGCAATGAGTTTCAAGATTTGCCCTCAGAAGATGAACTGGGTGAGG TATGGGTTGAGGTGAGGGCACAAGCACTCATCCTACCTACCCTGCTGCTGTTGAGGAGCTAGAAGTAAAACATATTGGTTAGGATTTTAACAGTTGGAGTAGCCTCCCATTATCAGATTAAGTGGGGGTCACTTTTGCTTCCAAACTCAG AATAAGTTTGTAAACATGGGAAAGTCTAAGCCAAGAGATCTAAAGCTCTAGAAATATTAATGACATTTCTGGGAGTAAAACTACTAAAAATTATATCTTAAAAGTTTCTAGTAGTATGAAGTTCCCAGGCCAGGCGCAGTGGCTCACGCC TGTAATCCCAACACTTTAGGAGGGCGAGGTGGGCAGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACTCCATCTCTACTAAAAATACAAAAATTAGCCGGGCATGATGGCAGGCACCTGTAATCTAAGCTAC TCGGGAGGCTGAGGCAAGAGAATCTCTTGAACCCAGGAGGCAAAGGTTGCAGTGAGCCAAGATCACGCCATCGCACTCCAGCCTGGGAGATTGAGCAACTTCGTCTCAAAAAAAAGTTTCCAGGAAAGATCTTTGGGTCCTACTAAGCGT CTCAATTTTGAGTTATGAATACTTTGGTTCAGGGAAGTAACCTGACATTTGGTTTTGCTGGAATTAGGGTTTTCGCTAGATTTGACTGCAATTAGGATTTCTTCTAGATTTTACCAGCAGTGATCTGAAAAAGTACAGGCTAGTCACAGA AATAGAGATGGATTTAGGATACTACACTATATTTCAAATGATTCTAGATGTGTAAATATAGTATGAACATTCTTGGAGAGGGGTGAGACAAACTGGACTTGCTGGGCCAACCCTGGCATGTTTTTCATTCTCCTCACTAGTTGACAAGGA TTGAAAATTCCGCTCCAGCCTAATGAGTGAACAGGATGGCTGCCCACAAAACCAAGTTATTAGCTTTATGTCATCGAAGCTCATATTCTCAAAGGCCCAAAGTGCTGTGCCGAGACAAATCCAAGTGCTGCTCTTGCTGAAGTGCGCACT GAAGTCCAGCTGTCCGTGCTTACAGCAGTGCCAAAAGTGGGGATTCCATGGACCAAAAACGGTGCCATAAGGGAAGCCAGAAGAGTTGCAGTGCAAGATCCTGGGAGAGATTATACCAAAGAAATCAAGCCTTTTTATCCTGATGCTTCT AAGATGATGAGGGTGAGCTGTGACAGATGCTGTGGGAGGGGAGTTCACATACATTCCATGTCAAGGCATTTAGCTGATAAATCCATCCTCAGAAAAGCACCTTTTTAAAAAGAAGTCCATTTTGTATATTAGAAGATGATGATGATGATG AAGATGAAGAAAGCCCTGGCAGATACAAAGTTCCTCAGTATTTAAGGAGAAGGATCTCTTCCATGTCCCCTTGACATGACTGTGGCTATTGCCCAAACCTCAGCTTGAGAACATCATATAATACTGAGAGCGGAAGATTTTTTTAAAGAG ATATGGTAGTTTAAATAGGTTTGTTTAAAGAACTCTTGGGAAATTTCTTAACAAATTGTAATTGTTTTTATAAACCTTCCTACAGAGTTGTGTACCATTCATCATCACCATCATTTAATATCTGTAAGTGCCCAGAAGGTACAAGGTGCT ATACAGCCGTTAAACACCCCCTCCCTGCAACTGTTTAAAATTAGAATAGATTTTTGCATCAACCACTGCTAGAAGCTTTCCCCACCTAGGTGGGCTGCAAGGGCCTGCATTCCCAACATCCCATTACATGTTTCCCACTCCAGAAAGTCT CTGGGTTTATTCCAGCTTTTTATCTTGACGTGTCCCATTCACCCCCATGGTTTGGTTTGGTTTGGTTTTGTTTTTTAAATCAAGAAAGTTTCAGGGAATCAAAAGAGGTCGGACATTTTTTAACCTAGCAGAAGTACAGAGTCATATATT TTGCTACGAATATTGTTGTAGTACAGAAAACCCACTTTGCCCGTTAGTGTGTGGATAGTATGTGTGTGTCCGCACTCATGATAACTTGAATGTTGAACCAGACATAGGGTTCATTTTTGAAAGGTTAAACCACACTGTTTCAGGAACTTG CTCCAAATACTACTTGGTTATCCCTTCCTTTACCAGTTAGAACTAAAGAGTGTGATGTATGAACACACTGGGTTGGGATTTTCTGTTGAGGATATGCAGGGCATTTTGGCATGAGGCAAATACAGAAGCAAGATTTCATTCTACTTGGTG ATTTGAATCATGACAGTCCTCATTCCAATCTCTCTTTAATTCTCTCTGGCCCTGCCCACACTCTGTATTTGAAAATCTTGTTTTTGCTCTTTCCGGAGCTTCACCCCTCTACTTACATATTGTAAAGTTGTATAAATCTATCATTGAAAG GTCCTCTCTGCCAGCAGTGGTGCCACCCTTTGGTTTGCTGTGGTACTTTGCTGTGTACTCCGTGGCATCATGTTACTGTGTAAATAAATTCATTTTAATACACACTAAAAAA |
| C-Truncated Transcript (5CDS-3UTR) Sequences |
Top |
Fusion Protein Sequence for ADAMTS7_PEAK1 |
| In-frame Fusion Protein Sequences. |
>ADAMTS7_PEAK1_ENST00000388820_ENST00000560626_79080572_77407661 length=441nt MPPDVGWAARGELSRRLRVRGPGCSPAAMDPPAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAVPVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDLHL RLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTDYRILLKELENLEIYTFLSKKCLKKLSREGSSHHLPRQVRPGP VYKPAPARNHRPRGGRGKASPTSFHVSPRAPLAPLASMPSSVPKTSVESLGSPSSLSSSKPREPLCPLKHPSHQPPASTLSPNPTSSTESLGETPHAGRWRQGSRFPQPGCANAAGRIRHQNPRHSHGHRISDIHEQLGIS |
| N-Truncated Protein (5UTR-3CDS) Sequences |
>ADAMTS7_PEAK1_ENST00000566303_ENST00000560626_79080572_77407661 length=302nt MFCITAAMYMFFFRCKDGLKGFTFSALRFIVGKEEIPTHSFSPEAAYAKVEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGS FVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGKFAVMNRKVLDVFGTGASKHFQDFIPRLDPRYTTVTPELPTE FS |
| C-Truncated Protein (5CDS-3UTR) Sequences |
Top |
Personalized Fusion Protein Sequence for ADAMTS7_PEAK1 |
| TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| TCGA All Mutated Fusion Protein Sequences |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
| CCLE All Mutated Fusion Protein Sequences |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
Top |
Fusion Gene Exprssed Samples for ADAMTS7_PEAK1 |
| RNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB | SARC | TCGA-DX-A23R-01A | ADAMTS7 | chr15 | 79080572 | - | PEAK1 | chr15 | 77407661 | - | |
| WashU | SARC | TCGA-DX-A23R-01A | ADAMTS7 | chr15 | 79080573 | - | PEAK1 | chr15 | 77407661 | - | |
| cBioPortal | SARC_TCGA_PAN_CAN_ATLAS_2018 | SOFT_TISSUE | TCGA-DX-A23R-01 | ADAMTS7 | chr15 | 78788231 | PEAK1 | chr15 | 77115319 |
| DNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | SV type |
Top |
Related Drugs for ADAMTS7_PEAK1 |
| PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug'] * For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub. |
| PMID | Fusion Gene Name | Drug | Study Title |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies