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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:BTBD9_LASP1 (FusionGDB2 ID:HG114781TG3927)

Fusion Gene Summary for BTBD9_LASP1

Fusion gene summary

Fusion gene information	Fusion gene name: BTBD9_LASP1
	Fusion gene ID: hg114781tg3927
		Hgene	Tgene
	Gene symbol	BTBD9	LASP1
	Gene ID	114781	3927
	Gene name	BTB domain containing 9	LIM and SH3 protein 1
	Synonyms	dJ322I12.1	Lasp-1\|MLN50
	Cytomap	6p21.2	17q12
	Type of gene	protein-coding	protein-coding
	Description	BTB/POZ domain-containing protein 9BTB (POZ) domain containing 9	LIM and SH3 domain protein 1metastatic lymph node gene 50 protein
	Modification date	20240403	20240407
	UniProtAcc	.	Q14847
	Ensembl transtripts involved in fusion gene	ENST00000481247, ENST00000314100, ENST00000403056, ENST00000408958, ENST00000419706,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 16 X 17 X 12=3264	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 10 X 24 X 15=3600
	# samples	27	32
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(27/326410)=-3.59560974492067 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(32/360010)=-3.49185309632968 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: BTBD9 [Title/Abstract] AND LASP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	BTBD9(38607575)-LASP1(37034338), # samples:1

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Fusion Gene Breakpoints for BTBD9_LASP1

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
BTBD9	chr6	38607575	LASP1	chr17	38607575
BTBD9	chr6	38607576	LASP1	chr17	37034339
BTBD9	chr6	38639800	LASP1	chr17	38878086

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for BTBD9_LASP1

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
BTBD9-LASP1	Promoter / Enhancer Hijacking M6		BTBD9 promoter drives elevated LASP1 expression, accelerating focal adhesion turnover, Src signaling, and metastatic cell migration.		Src/FAK inhibitors (dasatinib, defactinib); motility blockers		Invasive breast and colorectal carcinomas

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
BTBD9-LASP1	Promoter / Enhancer Hijacking M6		BTBD9 promoter drives elevated LASP1 expression, accelerating focal adhesion turnover, Src signaling, and metastatic cell migration.	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 36497077; Title: LASP1 in Cellular Signaling and Gene Expression: More than Just a Cytoskeletal Regulator.; PMID: 38230773; Title: Astragaloside IV regulates circ_0001615 and miR-873-5p/LASP1 axis to suppress colorectal cancer cell progression.	Src/FAK inhibitors (dasatinib, defactinib); motility blockers		Invasive breast and colorectal carcinomas	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 38230773; Title: Astragaloside IV regulates circ_0001615 and miR-873-5p/LASP1 axis to suppress colorectal cancer cell progression.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	LASP1 Q14847

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

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Fusion Genomic Features for BTBD9_LASP1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
BTBD9	chr6	38607575	-	LASP1	chr17	37034338	+	2.34e-08	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
BTBD9	chr6	38607575	-	LASP1	chr17	37034338	+	2.34e-08	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for BTBD9_LASP1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000481247	ENST00000318008	BTBD9	chr6	38607575	-	LASP1	chr17	37034338	+
5UTR-5UTR	ENST00000481247	ENST00000433206	BTBD9	chr6	38607575	-	LASP1	chr17	37034338	+
5UTR-5UTR	ENST00000481247	ENST00000435347	BTBD9	chr6	38607575	-	LASP1	chr17	37034338	+

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000481247	ENST00000318008	BTBD9	chr6	38607575	LASP1	chr17	37034338	0	940

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000481247	ENST00000318008	BTBD9	chr6	38607575	LASP1	chr17	37034338	0.00e+00	1.68e-02

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for BTBD9_LASP1

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for BTBD9_LASP1

In-frame Fusion Transcript Sequences.

N-Truncated Transcript (5UTR-3CDS) Sequences

>BTBD9_LASP1_ENST00000481247_ENST00000318008_38607575_37034338 length=3709nt 
 Breakpoint=0nt
TTCTGGCATAAAGCATGCTTCCATTGCGAGACCTGCAAGATGACACTGAACATGAAGAACTACAAGGGCTACGAGAAGAAGCCCTACTGCAACGCACACTACCCCAAGCAGTCCTTCACCATGGTGGCGGACACCCCGGAAAACCTTCGC
CTCAAGCAACAGAGTGAGCTCCAGAGTCAGGTGCGCTACAAGGAGGAGTTTGAGAAGAACAAGGGCAAAGGTTTCAGCGTAGTGGCAGACACGCCCGAGCTCCAGAGAATCAAGAAGACCCAGGACCAGATCAGTAACATAAAATACCAT
GAGGAGTTTGAGAAGAGCCGCATGGGCCCTAGCGGGGGCGAGGGCATGGAGCCAGAGCGTCGGGATTCACAGGACGGCAGCAGCTACCGGCGGCCCCTGGAGCAGCAGCAGCCTCACCACATCCCGACCAGTGCCCCGGTTTACCAGCAG
CCCCAGCAGCAGCCGGTGGCCCAGTCCTATGGTGGCTACAAGGAGCCTGCAGCCCCAGTCTCCATACAGCGCAGCGCCCCAGGTGGTGGCGGGAAGCGGTACCGCGCGGTGTATGACTACAGCGCCGCCGACGAGGACGAGGTCTCCTTC
CAGGACGGGGACACCATCGTCAACGTGCAGCAGATCGACGACGGCTGGATGTACGGGACGGTGGAGCGCACCGGCGACACGGGGATGCTGCCGGCCAACTACGTGGAGGCCATCTGAACCCGCAGCGCCCCCATCTGTCTTCAGCACATT
CCACGGCATCGCATCCGTCCTGGGCGTGACCCGTCCATTCTTCAGTGTCTCTGTTTTTTAAAACCTGCGACAGCTTGTGATTCCTACCCCTCTTCCAGCTTCTTTTGCCAACTGAAGCCTTCTTCTGCCACTTCTGCGGGCTCCCTCCTC
TGGCAGGCTTCCCCCTTGATCGACTTCTTGGTTTTCTCTCTGGATGGAACGGGCATGGGCCTCTCTGGGGGAGGCAGGGCTGGAATGGGAGACCTGTTGGCCTGTGGGCCTCACCTGCCCCTCTGTTCTCTCCCCTCACATCCTCCTGCC
CAGCTCCTCACATACCCACACATTCCAGGGCTGGGGTGAGCCTGACTGCCAGGACCCCAGGTCAGGGGCTCCCTACATTCCCCAGAGTGGGATCCACTTCTTGGTTCCTGGGATGGCGATGGGGACTCTGCCGCTGTGTAGGGACCAGTG
GGATGGGCTCTACCTCTCTTTCTCAAAGAGGGGGCTCTGCCCACCTGGGGTCTCTCTCCCTACCTCCCTCCTCAGGGGCAACAACAGGAGAATGGGGTTCCTGCTGTGGGGCGAATTCATCCCCTCCCCGCGCGTTCCTTCGCACACTGT
GATTTTGCCCTCCTGCCCACGCAGACCTGCAGCGGGCAAAGAGCTCCCGAGGAAGCACAGCTTGGGTCAGGTTCTTGCCTTTCTTAATTTTAGGGACAGCTACCGGAAGGAGGGGAACAAGGAGTTCTCTTCCGCAGCCCCTTTCCCCAC
GCCCACCCCCAGTCTCCAGGGACCCTTGCCTGCCTCCTAGGCTGGAAGCCATGGTCCCGAAGTGTAGGGCAAGGGTGCCTCAGGACCTTTTGGTCTTCAGCCTCCCTCAGCCCCCAGGATCTGGGTTAGGTGGCCGCTCCTCCCTGCTCC
TCATGGGAAGATGTCTCAGAGCCTTCCATGACCTCCCCTCCCCAGCCCAATGCCAAGTGGACTTGGAGCTGCACAAAGTCAGCAGGGACCACTAAATCTCCAAGACCTGGTGTGCGGAGGCAGGAGCATGTATGTCTGCAGGTGTCTGAC
ACGCAAGTGTGTGAGTGTGAGTGTGAGAGATGGGGCGGGGGTGTGTCTGTAGGTGTCTCTGGGCCTGTGTGTGGGTGGGGTTATGTGAGGGTATGAAGAGCTGTCTTCCCCTGAGAGTTTCCTCAGAACCCACAGTGAGAGGGGAGGGCT
CCTGGGGCAGAGAAGTTCCTTAGGTTTTCTTTGGAATGAAATTCCTCCTTCCCCCCATCTCTGAGTGGAGGAAGCCCACCAATCTGCCCTTTGCAGTGTGCAGGGTGGAAGGTAAGAGGTTGGTGTGGAGTTGGGGCTGCCATAGGGTCT
GCAGCCTGCTGGGGCTAAGCGGTGGAGGAAGGCTCTGTCACTCCAGGCATATGTTTCCCCATCTCTGTCTGGGGCTACAGAATAGGGTGGCAGAAGTGTCACCCTGTGGGTGTCTCCCTCGGGGGCTCTTCCCCTAGACCTCCCCCTCAC
TTACATAAAGCTCCCTTGAAGCAAGAAAGAGGGTCCCAGGGCTGCAAAACTGGAAGCACAGCCTCGGGGATGGGGAGGGAAAGACGGTGCTATATCCAGTTCCTGCTCTCTGCTCATGGGTGGCTGTGACAACCCTGGCCTCACTTGATT
CATCTCTGGTTTTCTTGCCACCCTCTGGGAGTCCCCATCCCATTTTCATCCTGAGCCCAACCAGGCCCTGCCATTGGCCTCTTGTCCCTTGGCACACTTGTACCCACAGGTGAGGGGCAGGACCTGAAGGTATTGGCCTGTTCAACAATC
AGTCATCATGGGTGTTTTTGTCAACTGCTTGTTAATTGATTTGGGGATGTTTGCCCCGAATGAGAGGTTGAGGAAAAGACTGTGGGTGGGGAGGCCCTGCCTGACCCATCCCTTTTCCTTTCTGGCCCCAGCCTAGGTGGAGGCAAGTGG
AATATCTTATATTGGGCGATTTGGGGGCTCGGGGAGGCAGAGAATCTCTTGGGAGTCTTGGGTGGCGCTGGTGCATTCTGTTTCCTCTTGATCTCAAAGCACAATGTGGATTTGGGGACCAAAGGTCAGGGACACATCCCCTTAGAGGAC
CTGAGTTTGGGAGAGTGGTGAGTGGAAGGGAGGAGCAGCAAGAAGCAGCCTGTTTTCACTCAGCTTAATTCTCCTTCCCAGATAAGGCAAGCCAGTCATGGAATCTTGCTGCAGGCCCTCCCTCTACTCTTCCTGTCCTAAAAATAGGGG
CCGTTTTCTTACACACCCCCAGAGAGAGGAGGGACTGTCACACTGGTGCTGAGTGACCGGGGGCTGCTGGGCGTCTGTTCTTTACCAAAACCATCCATCCCTAGAAGAGCACAGAGCCCTGAGGGGCTGGGCTGGGCTGGGCTGAGCCCC
TGGTCTTCTCTACAGTTCACAGAGGTCTTTCAGCTCATTTAATCCCAGGAAAGAGGCATCAAAGCTAGAATGTGAATATAACTTTTGTGGACCAATACTAAGAATAACAAGAAGCCCAGTGGTGAGGAAAGTGCGTTCTCCCAGCACTGC
CTCCTGTTTTCTCCCTCTCATGTCCCTCCAGGGAAAATGACTTTATTGCTTAATTTCTGCCTTTCCCCCCTCACACATGCACTTTTGGGCCTTTTTTTATAGCTGGAAAAAACAAAATACCACCCTACAAACCTGTATTTAAAAAGAAAC
AGAAATGACCACGTGAAATTTGCCTCTGTCCAAACATTTCATCCGTGTGTATGTGTATGTGTGTGAGTGTGTGAAGCCGCCAGTTCATCTTTTTATATGGGGTTGTTGTCTCATTTTGGTCTGTTTTGGTCCCCTCCCTCGTGGGCTTGT
GCTCGGGATCAAACCTTTCTGGCCTGTTATGATTCTGAACATTTGACTTGAACCACAAGTGAATCTTTCTCCTGGTGACTCAAATAAAAGTATAATTTTTACCTGCGGA

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for BTBD9_LASP1

In-frame Fusion Protein Sequences.

N-Truncated Protein (5UTR-3CDS) Sequences

>BTBD9_LASP1_ENST00000481247_ENST00000318008_38607575_37034338 length=940nt
MKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVNGRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIEN
KPLQEQLSVNQIKTEPVDYEFKPIVVASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLEQPSQ
LQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGDINALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQA
GQISVQSSEPSSPEPGKVNIPAKNNDQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYLYTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVT
DSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTENGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHEC
GICKKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEG
EEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for BTBD9_LASP1

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for BTBD9_LASP1

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		PRAD	TCGA-YL-A8SA-01A	BTBD9	chr6	38607575	-	LASP1	chr17	38607575	+
ChimerDB		PRAD	TCGA-YL-A8SA	BTBD9	chr6	38607575	-	LASP1	chr17	38607575	+
WashU		PRAD	TCGA-YL-A8SA-01A	BTBD9	chr6	38607576	-	LASP1	chr17	37034339	+
cBioPortal	PRAD_TCGA_PAN_CAN_ATLAS_2018	PRAD	TCGA-YL-A8SA-01	BTBD9	chr6	38639800		LASP1	chr17	38878086

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for BTBD9_LASP1

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status