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Fusion gene:AGAP1_PINX1 (FusionGDB2 ID:HG116987TG54984) |
Fusion Gene Summary for AGAP1_PINX1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AGAP1_PINX1 | Fusion gene ID: hg116987tg54984 | Hgene | Tgene | Gene symbol | AGAP1 | PINX1 | Gene ID | 116987 | 54984 |
| Gene name | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | PIN2 (TERF1) interacting telomerase inhibitor 1 | |
| Synonyms | AGAP-1|CENTG2|GGAP1|cnt-g2 | Gno1|LPTL|LPTS|Pxr1 | |
| Cytomap | 2q37.2 | 8p23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 1GTP-binding and GTPase-activating protein 1centaurin, gamma 2 | PIN2/TERF1-interacting telomerase inhibitor 167-11-3 proteinPIN2-interacting protein 1TRF1-interacting protein 1hepatocellular carcinoma-related putative tumor suppressorliver-related putative tumor suppressorpin2-interacting protein X1protein 67-1 | |
| Modification date | 20240305 | 20240305 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000304032, ENST00000336665, ENST00000409457, ENST00000409538, ENST00000428334, | ||
| Fusion gene scores | * DoF score | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 59 X 23 X 29=39353 | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 6 X 4 X 7=168 |
| # samples | 107 | 10 | |
| ** MAII score | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(107/39353*10)=-5.20079091925792 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(10/168*10)=-0.748461233004036 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AGAP1 [Title/Abstract] AND PINX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | AGAP1(236403493)-PINX1(10683754), # samples:2 | ||
| Fusion gene breakpoints across AGAP1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across PINX1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Breakpoints for AGAP1_PINX1 |
| RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| AGAP1 | chr2 | 236403493 | PINX1 | chr8 | 10683754 |
| DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | SV type |
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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for AGAP1_PINX1 |
| To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence. |
| Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions | Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity | Epigenetic Reprogramming / Histone Modifier Dysregulation | Chromatin Remodeling Dysregulation | Condensate-Driven Transcriptional Rewiring / LLP | Promoter / Enhancer Hijacking | Dominant-Negative Antagonism | Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation | Subcellular Mislocalization / Spatial Dysregulation | Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade |  |  |  |  |  |  |  |  |  |  |
* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
| AGAP1-PINX1 | Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation M8 | Fusion disrupts PIN2/TRF1-interacting telomerase inhibitor PINX1, leading to uncontrolled telomerase activation and immortalization. | Telomerase inhibitors (imetelstat); G-quadruplex stabilizers | Carcinomas and neuroepithelial tumors |
* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
| AGAP1-PINX1 | Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation M8 | Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 32028978; Title: Pin2 telomeric repeat factor 1-interacting telomerase inhibitor 1 (PinX1) inhibits nasopharyngeal cancer cell stemness: implication for cancer progression and therapeutic targeting.; PMID: 34873474; Title: PINX1 promotes malignant transformation of thyroid cancer through the activation of the AKT/MAPK/β-catenin signaling pathway. | Fusion disrupts PIN2/TRF1-interacting telomerase inhibitor PINX1, leading to uncontrolled telomerase activation and immortalization. | Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 32028978; Title: Pin2 telomeric repeat factor 1-interacting telomerase inhibitor 1 (PinX1) inhibits nasopharyngeal cancer cell stemness: implication for cancer progression and therapeutic targeting. | Telomerase inhibitors (imetelstat); G-quadruplex stabilizers | Carcinomas and neuroepithelial tumors | Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 35847001; Title: Hesperidin Inhibits Lung Cancer In Vitro and In Vivo Through PinX1.; PMID: 32028978; Title: Pin2 telomeric repeat factor 1-interacting telomerase inhibitor 1 (PinX1) inhibits nasopharyngeal cancer cell stemness: implication for cancer progression and therapeutic targeting. |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PINX1 | GO:0007004 | telomere maintenance via telomerase | 11701125 |
| Tgene | PINX1 | GO:0032211 | negative regulation of telomere maintenance via telomerase | 11701125 |
| Tgene | PINX1 | GO:0051974 | negative regulation of telomerase activity | 11701125 |
| Tgene | PINX1 | GO:1902570 | protein localization to nucleolus | 24415760 |
| Tgene | PINX1 | GO:1904744 | positive regulation of telomeric DNA binding | 19265708|24415760 |
| Tgene | PINX1 | GO:1904751 | positive regulation of protein localization to nucleolus | 19265708 |
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Fusion Genomic Features for AGAP1_PINX1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - | 3.70e-08 | 1.00e+00 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF). |
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Fusion Gene ORF Annotations for AGAP1_PINX1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000304032 | ENST00000314787 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| In-frame | ENST00000304032 | ENST00000426190 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| In-frame | ENST00000304032 | ENST00000519088 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| In-frame | ENST00000336665 | ENST00000314787 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| In-frame | ENST00000336665 | ENST00000426190 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| In-frame | ENST00000336665 | ENST00000519088 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| In-frame | ENST00000409457 | ENST00000314787 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| In-frame | ENST00000409457 | ENST00000426190 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| In-frame | ENST00000409457 | ENST00000519088 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ENST00000304032 | ENST00000314787 | AGAP1 | chr2 | 236403493 | PINX1 | chr8 | 10683754 | 743 | 255 |
| ENST00000304032 | ENST00000426190 | AGAP1 | chr2 | 236403493 | PINX1 | chr8 | 10683754 | 743 | 335 |
| ENST00000304032 | ENST00000519088 | AGAP1 | chr2 | 236403493 | PINX1 | chr8 | 10683754 | 743 | 255 |
| ENST00000336665 | ENST00000314787 | AGAP1 | chr2 | 236403493 | PINX1 | chr8 | 10683754 | 743 | 186 |
| ENST00000336665 | ENST00000426190 | AGAP1 | chr2 | 236403493 | PINX1 | chr8 | 10683754 | 743 | 335 |
| ENST00000336665 | ENST00000519088 | AGAP1 | chr2 | 236403493 | PINX1 | chr8 | 10683754 | 743 | 255 |
| ENST00000409457 | ENST00000314787 | AGAP1 | chr2 | 236403493 | PINX1 | chr8 | 10683754 | 761 | 255 |
| ENST00000409457 | ENST00000426190 | AGAP1 | chr2 | 236403493 | PINX1 | chr8 | 10683754 | 761 | 335 |
| ENST00000409457 | ENST00000519088 | AGAP1 | chr2 | 236403493 | PINX1 | chr8 | 10683754 | 761 | 255 |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| ENST00000304032 | ENST00000314787 | AGAP1 | chr2 | 236403493 | PINX1 | chr8 | 10683754 | 4.24e-03 | 9.96e-01 |
| ENST00000304032 | ENST00000426190 | AGAP1 | chr2 | 236403493 | PINX1 | chr8 | 10683754 | 1.67e-02 | 9.83e-01 |
| ENST00000304032 | ENST00000519088 | AGAP1 | chr2 | 236403493 | PINX1 | chr8 | 10683754 | 1.56e-02 | 9.84e-01 |
| ENST00000336665 | ENST00000314787 | AGAP1 | chr2 | 236403493 | PINX1 | chr8 | 10683754 | 4.24e-03 | 9.96e-01 |
| ENST00000336665 | ENST00000426190 | AGAP1 | chr2 | 236403493 | PINX1 | chr8 | 10683754 | 1.67e-02 | 9.83e-01 |
| ENST00000336665 | ENST00000519088 | AGAP1 | chr2 | 236403493 | PINX1 | chr8 | 10683754 | 1.56e-02 | 9.84e-01 |
| ENST00000409457 | ENST00000314787 | AGAP1 | chr2 | 236403493 | PINX1 | chr8 | 10683754 | 4.41e-03 | 9.96e-01 |
| ENST00000409457 | ENST00000426190 | AGAP1 | chr2 | 236403493 | PINX1 | chr8 | 10683754 | 1.44e-02 | 9.86e-01 |
| ENST00000409457 | ENST00000519088 | AGAP1 | chr2 | 236403493 | PINX1 | chr8 | 10683754 | 1.42e-02 | 9.86e-01 |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
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Fusion Protein Retained/Non-Retained Functional Features for AGAP1_PINX1 |
| Protein Level Annotation from FGviewer * Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS. |
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| - In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length). |
AGAP1_PINX1_chr2-236403493_chr8-10683754.png |
| - In-frame and retained protein feature among the 13 regional features (texts). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | PINX1 | chr2:236403493 | chr8:10683754 | ENST00000314787 | Q96BK5 | 3 | 7 | 161_174 | 100.33333333333333 | 329.0 | Compositional bias | Low complexity |
| Tgene | PINX1 | chr2:236403493 | chr8:10683754 | ENST00000314787 | Q96BK5 | 3 | 7 | 235_261 | 100.33333333333333 | 329.0 | Compositional bias | Basic and acidic residues |
| Tgene | PINX1 | chr2:236403493 | chr8:10683754 | ENST00000314787 | Q96BK5 | 3 | 7 | 292_303 | 100.33333333333333 | 329.0 | Compositional bias | Basic residues |
| Tgene | PINX1 | chr2:236403493 | chr8:10683754 | ENST00000314787 | Q96BK5 | 3 | 7 | 287_297 | 100.33333333333333 | 329.0 | Motif | Note=TBM |
| Tgene | PINX1 | chr2:236403493 | chr8:10683754 | ENST00000314787 | Q96BK5 | 3 | 7 | 147_177 | 100.33333333333333 | 329.0 | Region | Disordered |
| Tgene | PINX1 | chr2:236403493 | chr8:10683754 | ENST00000314787 | Q96BK5 | 3 | 7 | 189_307 | 100.33333333333333 | 329.0 | Region | Disordered |
| Tgene | PINX1 | chr2:236403493 | chr8:10683754 | ENST00000314787 | Q96BK5 | 3 | 7 | 254_328 | 100.33333333333333 | 329.0 | Region | Note=Telomerase inhibitory domain (TID) |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | Q9UPQ3 | 1 | 18 | 275_289 | 54.333333333333336 | 858.0 | Compositional bias | Low complexity |
| Hgene | AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | Q9UPQ3 | 1 | 18 | 322_337 | 54.333333333333336 | 858.0 | Compositional bias | Basic and acidic residues |
| Hgene | AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | Q9UPQ3 | 1 | 18 | 422_449 | 54.333333333333336 | 858.0 | Compositional bias | Polar residues |
| Hgene | AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | Q9UPQ3 | 1 | 18 | 504_514 | 54.333333333333336 | 858.0 | Compositional bias | Low complexity |
| Hgene | AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | Q9UPQ3 | 1 | 18 | 524_534 | 54.333333333333336 | 858.0 | Compositional bias | Basic residues |
| Hgene | AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | Q9UPQ3 | 1 | 18 | 346_588 | 54.333333333333336 | 858.0 | Domain | PH |
| Hgene | AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | Q9UPQ3 | 1 | 18 | 609_729 | 54.333333333333336 | 858.0 | Domain | Arf-GAP |
| Hgene | AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | Q9UPQ3 | 1 | 18 | 67_241 | 54.333333333333336 | 858.0 | Domain | GLD |
| Hgene | AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | Q9UPQ3 | 1 | 18 | 267_343 | 54.333333333333336 | 858.0 | Region | Disordered |
| Hgene | AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | Q9UPQ3 | 1 | 18 | 406_449 | 54.333333333333336 | 858.0 | Region | Disordered |
| Hgene | AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | Q9UPQ3 | 1 | 18 | 496_547 | 54.333333333333336 | 858.0 | Region | Disordered |
| Hgene | AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | Q9UPQ3 | 1 | 18 | 66_276 | 54.333333333333336 | 858.0 | Region | Note=Small GTPase-like |
| Hgene | AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | Q9UPQ3 | 1 | 18 | 768_797 | 54.333333333333336 | 858.0 | Repeat | Note=ANK 1 |
| Hgene | AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | Q9UPQ3 | 1 | 18 | 801_830 | 54.333333333333336 | 858.0 | Repeat | Note=ANK 2 |
| Hgene | AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | Q9UPQ3 | 1 | 18 | 624_647 | 54.333333333333336 | 858.0 | Zinc finger | C4-type |
| Tgene | PINX1 | chr2:236403493 | chr8:10683754 | ENST00000314787 | Q96BK5 | 3 | 7 | 26_72 | 100.33333333333333 | 329.0 | Domain | G-patch |
| Tgene | PINX1 | chr2:236403493 | chr8:10683754 | ENST00000314787 | Q96BK5 | 3 | 7 | 1_28 | 100.33333333333333 | 329.0 | Region | Disordered |
| - Retained PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Fusion Transcript Sequence for AGAP1_PINX1 |
| In-frame Fusion Transcript Sequences. |
>AGAP1_PINX1_ENST00000304032_ENST00000314787_236403493_10683754 length=1867nt Breakpoint=743nt CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGC CCAGGGGTCGGCCCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCC GCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCT GGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTCCTC GGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGAAGGATCTGTCATCTCGGAGCAAAACAGATCTTGACTGCATTTTTGGGAAAAGACAGAGTAA GAAGACTCCCGAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCCAGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTC TGAGACGCAGGTGGAACGTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAAAGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAA GAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGAGTTCCAAGGCCTCTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGAAGAAAAAGCTGCA AAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAATGAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGA AGTCACAGCAGAGTTCACCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTCCCAGGAGGACCTTTTTAATGTTCTCAATCGTGGCTCTCAGACACAAAT AAATTTTTTTGTAAACTCTGAGCCCTTCAGCAAGAGAGTTTAATTATAATCATTACAAATACATGCATTCATGTAAGTGTGCACACGTGTGTGTGCATGTGCGCATCTGTGTGTGTGTGTGTGTGTCACTATCTCCGTTTGCTCTCGGTT CCCTTCAATAACAATGAATGGTGCTTTCTTCTGAAAGACTCAGCCTAATTAAAGGATTAAGAGGCAA >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754 length=1788nt Breakpoint=743nt CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGC CCAGGGGTCGGCCCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCC GCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCT GGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTCCTC GGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCC AGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAACGTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCC AGCCTAAGGCCAAGAGGCACACGGAGGGAAAGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGAGTTCCAAGGCCTCTGCTCAGGATGCAGGGG ACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGAAGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAAT GAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCACCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTC GCCACATTTCCCCCAAGTTACATTCCCAGGAGGACCTTTTTAATGTTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGAGCCCTTCAGCAAGAGAGTTTAATTATAATCATTACAAATACATGCATTCATGTAAG TGTGCACACGTGTGTGTGCATGTGCGCATCTGTGTGTGTGTGTGTGTGTCACTATCTCCGTTTGCTCTCGGTTCCCTTCAATAACAATGAATGGTGCTTTCTTCTGAAAGACTCAGCCTAATTAAAGGATTAAGAGGC >AGAP1_PINX1_ENST00000304032_ENST00000519088_236403493_10683754 length=1594nt Breakpoint=743nt CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGC CCAGGGGTCGGCCCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCC GCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCT GGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTCCTC GGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCC AGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAACGTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCC AGCCTAAGGCCAAGAGGCACACGGAGGGAAAGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGAGTTCCAAGGCCTCTGCTCAGGATGCAGGGG ACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGAAGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAAT GAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCACCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTC GCCACATTTCCCCCAAGTTACATTCCCAGGAGGACCTTTTTAATGTTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGA >AGAP1_PINX1_ENST00000336665_ENST00000314787_236403493_10683754 length=1867nt Breakpoint=743nt CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGC CCAGGGGTCGGCCCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCC GCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCT GGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTCCTC GGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGAAGGATCTGTCATCTCGGAGCAAAACAGATCTTGACTGCATTTTTGGGAAAAGACAGAGTAA GAAGACTCCCGAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCCAGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTC TGAGACGCAGGTGGAACGTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAAAGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAA GAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGAGTTCCAAGGCCTCTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGAAGAAAAAGCTGCA AAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAATGAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGA AGTCACAGCAGAGTTCACCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTCCCAGGAGGACCTTTTTAATGTTCTCAATCGTGGCTCTCAGACACAAAT AAATTTTTTTGTAAACTCTGAGCCCTTCAGCAAGAGAGTTTAATTATAATCATTACAAATACATGCATTCATGTAAGTGTGCACACGTGTGTGTGCATGTGCGCATCTGTGTGTGTGTGTGTGTGTCACTATCTCCGTTTGCTCTCGGTT CCCTTCAATAACAATGAATGGTGCTTTCTTCTGAAAGACTCAGCCTAATTAAAGGATTAAGAGGCAA >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754 length=1788nt Breakpoint=743nt CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGC CCAGGGGTCGGCCCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCC GCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCT GGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTCCTC GGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCC AGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAACGTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCC AGCCTAAGGCCAAGAGGCACACGGAGGGAAAGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGAGTTCCAAGGCCTCTGCTCAGGATGCAGGGG ACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGAAGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAAT GAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCACCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTC GCCACATTTCCCCCAAGTTACATTCCCAGGAGGACCTTTTTAATGTTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGAGCCCTTCAGCAAGAGAGTTTAATTATAATCATTACAAATACATGCATTCATGTAAG TGTGCACACGTGTGTGTGCATGTGCGCATCTGTGTGTGTGTGTGTGTGTCACTATCTCCGTTTGCTCTCGGTTCCCTTCAATAACAATGAATGGTGCTTTCTTCTGAAAGACTCAGCCTAATTAAAGGATTAAGAGGC >AGAP1_PINX1_ENST00000336665_ENST00000519088_236403493_10683754 length=1594nt Breakpoint=743nt CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGC CCAGGGGTCGGCCCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCC GCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCT GGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTCCTC GGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCC AGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAACGTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCC AGCCTAAGGCCAAGAGGCACACGGAGGGAAAGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGAGTTCCAAGGCCTCTGCTCAGGATGCAGGGG ACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGAAGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAAT GAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCACCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTC GCCACATTTCCCCCAAGTTACATTCCCAGGAGGACCTTTTTAATGTTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGA >AGAP1_PINX1_ENST00000409457_ENST00000314787_236403493_10683754 length=1885nt Breakpoint=761nt GGCGCTCGGAGCGGGCTCCGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGA GCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGCAAGCCTCCTTCG GGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCC GCGCCTTTCTTCTCGCGCCTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCAT GAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCAT CGCCATCGAAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGAAGGATCTGTCATCTCGGAGCAAAACAGATCTTGACTGCATTTT TGGGAAAAGACAGAGTAAGAAGACTCCCGAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCCAGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGT TCCAGGGTCTGACATTTCTGAGACGCAGGTGGAACGTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAAAGCCCGAGAGGGCCGAGGCCCAGGA GCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGAGTTCCAAGGCCTCTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAG AGGGAAGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAATGAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGG CAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCACCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTCCCAGGAGGACCTTTTTAATGTTCTCAATCG TGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGAGCCCTTCAGCAAGAGAGTTTAATTATAATCATTACAAATACATGCATTCATGTAAGTGTGCACACGTGTGTGTGCATGTGCGCATCTGTGTGTGTGTGTGTGTGTCACTAT CTCCGTTTGCTCTCGGTTCCCTTCAATAACAATGAATGGTGCTTTCTTCTGAAAGACTCAGCCTAATTAAAGGATTAAGAGGCAA >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754 length=1806nt Breakpoint=761nt GGCGCTCGGAGCGGGCTCCGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGA GCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGCAAGCCTCCTTCG GGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCC GCGCCTTTCTTCTCGCGCCTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCAT GAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCAT CGCCATCGAAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAA CCAGCGCCTTCACCATCCAGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAACGTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAG ATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAAAGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGAGTTCCAAGGCCT CTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGAAGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGA AGAAGAAAGATTCCAAATGAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCACCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCT GCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTCCCAGGAGGACCTTTTTAATGTTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGAGCCCTTCAGCAAGAGAGTTTAATTATAATCATTACAAA TACATGCATTCATGTAAGTGTGCACACGTGTGTGTGCATGTGCGCATCTGTGTGTGTGTGTGTGTGTCACTATCTCCGTTTGCTCTCGGTTCCCTTCAATAACAATGAATGGTGCTTTCTTCTGAAAGACTCAGCCTAATTAAAGGATTA AGAGGC >AGAP1_PINX1_ENST00000409457_ENST00000519088_236403493_10683754 length=1612nt Breakpoint=761nt GGCGCTCGGAGCGGGCTCCGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGA GCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGCAAGCCTCCTTCG GGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCC GCGCCTTTCTTCTCGCGCCTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCAT GAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCAT CGCCATCGAAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAA CCAGCGCCTTCACCATCCAGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAACGTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAG ATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAAAGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGAGTTCCAAGGCCT CTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGAAGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGA AGAAGAAAGATTCCAAATGAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCACCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCT GCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTCCCAGGAGGACCTTTTTAATGTTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGA |
| N-Truncated Transcript (5UTR-3CDS) Sequences |
| C-Truncated Transcript (5CDS-3UTR) Sequences |
Top |
Fusion Protein Sequence for AGAP1_PINX1 |
| In-frame Fusion Protein Sequences. |
>AGAP1_PINX1_ENST00000304032_ENST00000314787_236403493_10683754 length=255nt MSDPGTGTWGLFFSAAIRLAKYSWMVKALVVVVSFSSGVEGLASPFCEFHIVNTVFGDFGLFLKAKRFLFLLVRGIFDGDDVLPDLVLQHRLLHALQQLVDGVDVGVDRLEALDLGPDGSRVGQLLLVVHGAGAAPGAARPPPPPPRAPG PAGRRARGAAAPGEPGPPAAGGGGARRKARAEQARGWPAGSVHGRDARPASERAPASRVSGPPGGSAPPWSAPRRVRPAPKEACSGDFLSRSRLPALGAAPRSSH >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754 length=335nt MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000519088_236403493_10683754 length=255nt MSDPGTGTWGLFFSAAIRLAKYSWMVKALVVVVSFSSGVEGLASPFCEFHIVNTVFGDFGLFLKAKRFLFLLVRGIFDGDDVLPDLVLQHRLLHALQQLVDGVDVGVDRLEALDLGPDGSRVGQLLLVVHGAGAAPGAARPPPPPPRAPG PAGRRARGAAAPGEPGPPAAGGGGARRKARAEQARGWPAGSVHGRDARPASERAPASRVSGPPGGSAPPWSAPRRVRPAPKEACSGDFLSRSRLPALGAAPRSSH >AGAP1_PINX1_ENST00000336665_ENST00000314787_236403493_10683754 length=186nt MFSAAAIFDGDDVLPDLVLQHRLLHALQQLVDGVDVGVDRLEALDLGPDGSRVGQLLLVVHGAGAAPGAARPPPPPPRAPGPAGRRARGAAAPGEPGPPAAGGGGARRKARAEQARGWPAGSVHGRDARPASERAPASRVSGPPGGSAPP WSAPRRVRPAPKEACSGDFLSRSRLPALGAAPRSSH >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754 length=335nt MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000519088_236403493_10683754 length=255nt MSDPGTGTWGLFFSAAIRLAKYSWMVKALVVVVSFSSGVEGLASPFCEFHIVNTVFGDFGLFLKAKRFLFLLVRGIFDGDDVLPDLVLQHRLLHALQQLVDGVDVGVDRLEALDLGPDGSRVGQLLLVVHGAGAAPGAARPPPPPPRAPG PAGRRARGAAAPGEPGPPAAGGGGARRKARAEQARGWPAGSVHGRDARPASERAPASRVSGPPGGSAPPWSAPRRVRPAPKEACSGDFLSRSRLPALGAAPRSSH >AGAP1_PINX1_ENST00000409457_ENST00000314787_236403493_10683754 length=255nt MSDPGTGTWGLFFSAAIRLAKYSWMVKALVVVVSFSSGVEGLASPFCEFHIVNTVFGDFGLFLKAKRFLFLLVRGIFDGDDVLPDLVLQHRLLHALQQLVDGVDVGVDRLEALDLGPDGSRVGQLLLVVHGAGAAPGAARPPPPPPRAPG PAGRRARGAAAPGEPGPPAAGGGGARRKARAEQARGWPAGSVHGRDARPASERAPASRVSGPPGGSAPPWSAPRRVRPAPKEACSGDFLSRSRLPALGAAPRSSH >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754 length=335nt MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000519088_236403493_10683754 length=255nt MSDPGTGTWGLFFSAAIRLAKYSWMVKALVVVVSFSSGVEGLASPFCEFHIVNTVFGDFGLFLKAKRFLFLLVRGIFDGDDVLPDLVLQHRLLHALQQLVDGVDVGVDRLEALDLGPDGSRVGQLLLVVHGAGAAPGAARPPPPPPRAPG PAGRRARGAAAPGEPGPPAAGGGGARRKARAEQARGWPAGSVHGRDARPASERAPASRVSGPPGGSAPPWSAPRRVRPAPKEACSGDFLSRSRLPALGAAPRSSH |
| N-Truncated Protein (5UTR-3CDS) Sequences |
| C-Truncated Protein (5CDS-3UTR) Sequences |
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Personalized Fusion Protein Sequence for AGAP1_PINX1 |
| TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| TCGA All Mutated Fusion Protein Sequences |
>AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.E307D_335_E314D length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVDIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.K321N_335_K328N length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKNKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.R209L_335_R216L length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVELKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.D201N_335_D208N length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSNISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.R185L_335_R192L length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKLMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.V306L_335_V313L length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPLEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.M186I_335_M193I length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRIAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.G278V_335_G285V length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAVDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.A274T_335_A281T length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASTQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.Q194R_335_Q201R length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPRVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.K184T_335_K191T length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFATRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.A312T_335_A319T length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDTTLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.G286D_335_G293D length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEDRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.T205M_335_T212M length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISEMQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.K133N_335_K140N length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGNDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.P196L_335_P203L length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVLVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.D159N_335_D166N length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGNASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.A219V_335_A226V length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEVTGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.T205M_335_T212M length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISEMQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.Q179K_335_Q186K length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIKEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.A187T_335_A194T length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMTALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.G298W_335_G305W length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRWKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.E316K_335_E323K length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEKTLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.A312T_335_A319T length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDTTLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.E180K_335_E187K length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQKYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.L143F_335_L150F length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDF DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.R209C_335_R216C length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVECKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.E285K_335_E292K length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPKGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.D144H_335_D151H length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL HCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.R242K_335_R249K length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPEKAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.T317M_335_T324M length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEEMLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.P283L_335_P290L length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQLPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000304032_ENST00000426190_236403493_10683754_3-gene_p.P156L_335_P163L length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTLEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.E307D_335_E314D length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVDIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.K321N_335_K328N length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKNKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.R209L_335_R216L length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVELKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.D201N_335_D208N length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSNISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.R185L_335_R192L length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKLMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.V306L_335_V313L length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPLEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.M186I_335_M193I length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRIAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.G278V_335_G285V length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAVDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.A274T_335_A281T length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASTQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.Q194R_335_Q201R length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPRVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.K184T_335_K191T length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFATRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.A312T_335_A319T length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDTTLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.G286D_335_G293D length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEDRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.T205M_335_T212M length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISEMQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.K133N_335_K140N length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGNDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.P196L_335_P203L length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVLVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.D159N_335_D166N length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGNASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.A219V_335_A226V length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEVTGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.T205M_335_T212M length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISEMQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.Q179K_335_Q186K length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIKEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.A187T_335_A194T length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMTALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.G298W_335_G305W length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRWKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.E316K_335_E323K length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEKTLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.A312T_335_A319T length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDTTLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.E180K_335_E187K length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQKYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.L143F_335_L150F length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDF DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.R209C_335_R216C length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVECKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.E285K_335_E292K length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPKGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.D144H_335_D151H length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL HCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.R242K_335_R249K length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPEKAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.T317M_335_T324M length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEEMLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.P283L_335_P290L length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQLPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000336665_ENST00000426190_236403493_10683754_3-gene_p.P156L_335_P163L length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTLEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.E307D_335_E314D length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVDIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.K321N_335_K328N length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKNKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.R209L_335_R216L length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVELKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.D201N_335_D208N length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSNISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.R185L_335_R192L length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKLMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.V306L_335_V313L length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPLEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.M186I_335_M193I length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRIAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.G278V_335_G285V length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAVDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.A274T_335_A281T length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASTQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.Q194R_335_Q201R length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPRVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.K184T_335_K191T length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFATRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.A312T_335_A319T length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDTTLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.G286D_335_G293D length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEDRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.T205M_335_T212M length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISEMQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.K133N_335_K140N length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGNDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.P196L_335_P203L length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVLVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.D159N_335_D166N length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGNASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.A219V_335_A226V length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEVTGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.T205M_335_T212M length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISEMQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.Q179K_335_Q186K length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIKEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.A187T_335_A194T length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMTALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.G298W_335_G305W length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRWKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.E316K_335_E323K length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEKTLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.A312T_335_A319T length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDTTLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.E180K_335_E187K length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQKYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.L143F_335_L150F length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDF DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.R209C_335_R216C length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVECKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.E285K_335_E292K length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPKGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.D144H_335_D151H length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL HCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.R242K_335_R249K length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPEKAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.T317M_335_T324M length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEEMLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.P283L_335_P290L length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQLPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK >AGAP1_PINX1_ENST00000409457_ENST00000426190_236403493_10683754_3-gene_p.P156L_335_P163L length=335AA MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDL DCIFGKRQSKKTLEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKP KKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-13-0891-01A | 3-gene | p.E307D | 335 | E314D |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-38-4625-01A | 3-gene | p.K321N | 335 | K328N |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-55-8299-01A | 3-gene | p.R209L | 335 | R216L |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-69-7980-01A | 3-gene | p.D201N | 335 | D208N |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-73-4668-01A | 3-gene | p.R185L | 335 | R192L |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-75-6214-01A | 3-gene | p.V306L | 335 | V313L |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-78-7155-01A | 3-gene | p.M186I | 335 | M193I |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-95-7043-01A | 3-gene | p.G278V | 335 | G285V |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-A5-A0G2-01A | 3-gene | p.A274T | 335 | A281T |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-A8-A09Z-01A | 3-gene | p.Q194R | 335 | Q201R |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-AA-3851-01A | 3-gene | p.K184T | 335 | K191T |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-AA-A010-01A | 3-gene | p.A312T | 335 | A319T |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-BH-A1EY-01A | 3-gene | p.G286D | 335 | G293D |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-CG-5732-01A | 3-gene | p.T205M | 335 | T212M |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-D1-A1NS-01A | 3-gene | p.K133N | 335 | K140N |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-D3-A8GB-06A | 3-gene | p.P196L | 335 | P203L |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-D8-A146-01A | 3-gene | p.D159N | 335 | D166N |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-DF-A2KU-01A | 3-gene | p.A219V | 335 | A226V |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-DK-A3X2-01A | 3-gene | p.T205M | 335 | T212M |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-DX-AB2O-01A | 3-gene | p.Q179K | 335 | Q186K |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-E7-A3Y1-01A | 3-gene | p.A187T | 335 | A194T |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-EE-A20F-06A | 3-gene | p.G298W | 335 | G305W |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-EE-A2GB-06A | 3-gene | p.E316K | 335 | E323K |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-EI-6507-01A | 3-gene | p.A312T | 335 | A319T |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-EK-A2R7-01A | 3-gene | p.E180K | 335 | E187K |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-EO-A22R-01A | 3-gene | p.L143F | 335 | L150F |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-FI-A2D0-01A | 3-gene | p.R209C | 335 | R216C |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-FU-A2QG-01A | 3-gene | p.E285K | 335 | E292K |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-GC-A4ZW-01A | 3-gene | p.D144H | 335 | D151H |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-L9-A7SV-01A | 3-gene | p.R242K | 335 | R249K |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-QG-A5YX-01A | 3-gene | p.T317M | 335 | T324M |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-UF-A71E-01A | 3-gene | p.P283L | 335 | P290L |
| ENST00000304032_ENST00000426190_236403493_10683754 | TCGA-WE-A8K5-06A | 3-gene | p.P156L | 335 | P163L |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-13-0891-01A | 3-gene | p.E307D | 335 | E314D |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-38-4625-01A | 3-gene | p.K321N | 335 | K328N |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-55-8299-01A | 3-gene | p.R209L | 335 | R216L |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-69-7980-01A | 3-gene | p.D201N | 335 | D208N |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-73-4668-01A | 3-gene | p.R185L | 335 | R192L |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-75-6214-01A | 3-gene | p.V306L | 335 | V313L |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-78-7155-01A | 3-gene | p.M186I | 335 | M193I |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-95-7043-01A | 3-gene | p.G278V | 335 | G285V |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-A5-A0G2-01A | 3-gene | p.A274T | 335 | A281T |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-A8-A09Z-01A | 3-gene | p.Q194R | 335 | Q201R |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-AA-3851-01A | 3-gene | p.K184T | 335 | K191T |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-AA-A010-01A | 3-gene | p.A312T | 335 | A319T |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-BH-A1EY-01A | 3-gene | p.G286D | 335 | G293D |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-CG-5732-01A | 3-gene | p.T205M | 335 | T212M |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-D1-A1NS-01A | 3-gene | p.K133N | 335 | K140N |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-D3-A8GB-06A | 3-gene | p.P196L | 335 | P203L |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-D8-A146-01A | 3-gene | p.D159N | 335 | D166N |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-DF-A2KU-01A | 3-gene | p.A219V | 335 | A226V |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-DK-A3X2-01A | 3-gene | p.T205M | 335 | T212M |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-DX-AB2O-01A | 3-gene | p.Q179K | 335 | Q186K |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-E7-A3Y1-01A | 3-gene | p.A187T | 335 | A194T |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-EE-A20F-06A | 3-gene | p.G298W | 335 | G305W |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-EE-A2GB-06A | 3-gene | p.E316K | 335 | E323K |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-EI-6507-01A | 3-gene | p.A312T | 335 | A319T |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-EK-A2R7-01A | 3-gene | p.E180K | 335 | E187K |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-EO-A22R-01A | 3-gene | p.L143F | 335 | L150F |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-FI-A2D0-01A | 3-gene | p.R209C | 335 | R216C |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-FU-A2QG-01A | 3-gene | p.E285K | 335 | E292K |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-GC-A4ZW-01A | 3-gene | p.D144H | 335 | D151H |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-L9-A7SV-01A | 3-gene | p.R242K | 335 | R249K |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-QG-A5YX-01A | 3-gene | p.T317M | 335 | T324M |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-UF-A71E-01A | 3-gene | p.P283L | 335 | P290L |
| ENST00000336665_ENST00000426190_236403493_10683754 | TCGA-WE-A8K5-06A | 3-gene | p.P156L | 335 | P163L |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-13-0891-01A | 3-gene | p.E307D | 335 | E314D |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-38-4625-01A | 3-gene | p.K321N | 335 | K328N |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-55-8299-01A | 3-gene | p.R209L | 335 | R216L |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-69-7980-01A | 3-gene | p.D201N | 335 | D208N |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-73-4668-01A | 3-gene | p.R185L | 335 | R192L |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-75-6214-01A | 3-gene | p.V306L | 335 | V313L |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-78-7155-01A | 3-gene | p.M186I | 335 | M193I |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-95-7043-01A | 3-gene | p.G278V | 335 | G285V |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-A5-A0G2-01A | 3-gene | p.A274T | 335 | A281T |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-A8-A09Z-01A | 3-gene | p.Q194R | 335 | Q201R |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-AA-3851-01A | 3-gene | p.K184T | 335 | K191T |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-AA-A010-01A | 3-gene | p.A312T | 335 | A319T |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-BH-A1EY-01A | 3-gene | p.G286D | 335 | G293D |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-CG-5732-01A | 3-gene | p.T205M | 335 | T212M |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-D1-A1NS-01A | 3-gene | p.K133N | 335 | K140N |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-D3-A8GB-06A | 3-gene | p.P196L | 335 | P203L |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-D8-A146-01A | 3-gene | p.D159N | 335 | D166N |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-DF-A2KU-01A | 3-gene | p.A219V | 335 | A226V |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-DK-A3X2-01A | 3-gene | p.T205M | 335 | T212M |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-DX-AB2O-01A | 3-gene | p.Q179K | 335 | Q186K |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-E7-A3Y1-01A | 3-gene | p.A187T | 335 | A194T |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-EE-A20F-06A | 3-gene | p.G298W | 335 | G305W |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-EE-A2GB-06A | 3-gene | p.E316K | 335 | E323K |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-EI-6507-01A | 3-gene | p.A312T | 335 | A319T |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-EK-A2R7-01A | 3-gene | p.E180K | 335 | E187K |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-EO-A22R-01A | 3-gene | p.L143F | 335 | L150F |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-FI-A2D0-01A | 3-gene | p.R209C | 335 | R216C |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-FU-A2QG-01A | 3-gene | p.E285K | 335 | E292K |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-GC-A4ZW-01A | 3-gene | p.D144H | 335 | D151H |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-L9-A7SV-01A | 3-gene | p.R242K | 335 | R249K |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-QG-A5YX-01A | 3-gene | p.T317M | 335 | T324M |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-UF-A71E-01A | 3-gene | p.P283L | 335 | P290L |
| ENST00000409457_ENST00000426190_236403493_10683754 | TCGA-WE-A8K5-06A | 3-gene | p.P156L | 335 | P163L |
| CCLE All Mutated Fusion Protein Sequences |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
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Fusion Gene Exprssed Samples for AGAP1_PINX1 |
| RNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB | OV | TCGA-24-1544-01A | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - | |
| ChimerDB | OV | TCGA-24-1544 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - | |
| WashU | OV | TCGA-24-1544-01A | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| DNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | SV type |
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Related Drugs for AGAP1_PINX1 |
| PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug'] * For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub. |
| PMID | Fusion Gene Name | Drug | Study Title |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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