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Fusion gene:AGAP1_CIR1 (FusionGDB2 ID:HG116987TG9541) |
Fusion Gene Summary for AGAP1_CIR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AGAP1_CIR1 | Fusion gene ID: hg116987tg9541 | Hgene | Tgene | Gene symbol | AGAP1 | CIR1 | Gene ID | 116987 | 9541 |
| Gene name | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | corepressor interacting with RBPJ, CIR1 | |
| Synonyms | AGAP-1|CENTG2|GGAP1|cnt-g2 | CIR | |
| Cytomap | 2q37.2 | 2q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 1GTP-binding and GTPase-activating protein 1centaurin, gamma 2 | corepressor interacting with RBPJ 1CBF1 (RBPJ) interacting corepressor 1CBF1-interacting corepressorcorepressor interacting with RBPJ, 1recepin | |
| Modification date | 20240305 | 20240305 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000304032, ENST00000336665, ENST00000409457, ENST00000409538, ENST00000428334, | ||
| Fusion gene scores | * DoF score | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 59 X 23 X 29=39353 | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 5 X 4 X 5=100 |
| # samples | 107 | 144 | |
| ** MAII score | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(107/39353*10)=-5.20079091925792 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(144/100*10)=3.84799690655495 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: AGAP1 [Title/Abstract] AND CIR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | AGAP1(236715975)-CIR1(175252507), # samples:2 | ||
| Fusion gene breakpoints across AGAP1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CIR1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Breakpoints for AGAP1_CIR1 |
| RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| AGAP1 | chr2 | 236715975 | CIR1 | chr2 | 175252507 |
| DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | SV type |
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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for AGAP1_CIR1 |
| To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence. |
| Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions | Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity | Epigenetic Reprogramming / Histone Modifier Dysregulation | Chromatin Remodeling Dysregulation | Condensate-Driven Transcriptional Rewiring / LLP | Promoter / Enhancer Hijacking | Dominant-Negative Antagonism | Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation | Subcellular Mislocalization / Spatial Dysregulation | Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade |  |  |  |  |  |  |  |  |  |  |
* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CIR1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 9874765 |
| Tgene | CIR1 | GO:0045892 | negative regulation of DNA-templated transcription | 9874765 |
| Tgene | CIR1 | GO:0045892 | negative regulation of DNA-templated transcription | 9874765 |
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Fusion Genomic Features for AGAP1_CIR1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| AGAP1 | chr2 | 236715975 | + | CIR1 | chr2 | 175252507 | - | 2.54e-03 | 9.97e-01 |
| AGAP1 | chr2 | 236715975 | - | CIR1 | chr2 | 175252507 | - | 1.00e+00 | 3.27e-05 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF). |
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Fusion Gene ORF Annotations for AGAP1_CIR1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000304032 | ENST00000342016 | AGAP1 | chr2 | 236715975 | - | CIR1 | chr2 | 175252507 | - |
| In-frame | ENST00000304032 | ENST00000362053 | AGAP1 | chr2 | 236715975 | - | CIR1 | chr2 | 175252507 | - |
| In-frame | ENST00000336665 | ENST00000342016 | AGAP1 | chr2 | 236715975 | - | CIR1 | chr2 | 175252507 | - |
| In-frame | ENST00000336665 | ENST00000362053 | AGAP1 | chr2 | 236715975 | - | CIR1 | chr2 | 175252507 | - |
| In-frame | ENST00000409457 | ENST00000342016 | AGAP1 | chr2 | 236715975 | - | CIR1 | chr2 | 175252507 | - |
| In-frame | ENST00000409457 | ENST00000362053 | AGAP1 | chr2 | 236715975 | - | CIR1 | chr2 | 175252507 | - |
| In-frame | ENST00000409538 | ENST00000342016 | AGAP1 | chr2 | 236715975 | - | CIR1 | chr2 | 175252507 | - |
| In-frame | ENST00000409538 | ENST00000362053 | AGAP1 | chr2 | 236715975 | - | CIR1 | chr2 | 175252507 | - |
| In-frame | ENST00000428334 | ENST00000342016 | AGAP1 | chr2 | 236715975 | - | CIR1 | chr2 | 175252507 | - |
| In-frame | ENST00000428334 | ENST00000362053 | AGAP1 | chr2 | 236715975 | - | CIR1 | chr2 | 175252507 | - |
| ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| ENST00000304032 | ENST00000342016 | AGAP1 | chr2 | 236715975 | CIR1 | chr2 | 175252507 | 7.19e-05 | 1.00e+00 |
| ENST00000304032 | ENST00000362053 | AGAP1 | chr2 | 236715975 | CIR1 | chr2 | 175252507 | 3.51e-04 | 1.00e+00 |
| ENST00000336665 | ENST00000342016 | AGAP1 | chr2 | 236715975 | CIR1 | chr2 | 175252507 | 7.19e-05 | 1.00e+00 |
| ENST00000336665 | ENST00000362053 | AGAP1 | chr2 | 236715975 | CIR1 | chr2 | 175252507 | 3.51e-04 | 1.00e+00 |
| ENST00000409457 | ENST00000342016 | AGAP1 | chr2 | 236715975 | CIR1 | chr2 | 175252507 | 7.09e-05 | 1.00e+00 |
| ENST00000409457 | ENST00000362053 | AGAP1 | chr2 | 236715975 | CIR1 | chr2 | 175252507 | 3.43e-04 | 1.00e+00 |
| ENST00000409538 | ENST00000342016 | AGAP1 | chr2 | 236715975 | CIR1 | chr2 | 175252507 | 2.77e-05 | 1.00e+00 |
| ENST00000409538 | ENST00000362053 | AGAP1 | chr2 | 236715975 | CIR1 | chr2 | 175252507 | 1.04e-04 | 1.00e+00 |
| ENST00000428334 | ENST00000342016 | AGAP1 | chr2 | 236715975 | CIR1 | chr2 | 175252507 | 7.10e-04 | 9.99e-01 |
| ENST00000428334 | ENST00000362053 | AGAP1 | chr2 | 236715975 | CIR1 | chr2 | 175252507 | 3.97e-03 | 9.96e-01 |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
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Fusion Protein Retained/Non-Retained Functional Features for AGAP1_CIR1 |
| Protein Level Annotation from FGviewer * Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS. |
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| - In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length). |
AGAP1_CIR1_chr2-236715975_chr2-175252507.png |
| - In-frame and retained protein feature among the 13 regional features (texts). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | Q9UPQ3 | 9 | 18 | 275_289 | 350.0 | 858.0 | Compositional bias | Low complexity |
| Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | Q9UPQ3 | 9 | 18 | 322_337 | 350.0 | 858.0 | Compositional bias | Basic and acidic residues |
| Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | Q9UPQ3 | 9 | 18 | 67_241 | 350.0 | 858.0 | Domain | GLD |
| Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | Q9UPQ3 | 9 | 18 | 267_343 | 350.0 | 858.0 | Region | Disordered |
| Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | Q9UPQ3 | 9 | 18 | 66_276 | 350.0 | 858.0 | Region | Note=Small GTPase-like |
| Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000342016 | Q86X95 | 0 | 10 | 233_257 | 24.0 | 451.0 | Compositional bias | Basic residues |
| Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000342016 | Q86X95 | 0 | 10 | 258_281 | 24.0 | 451.0 | Compositional bias | Low complexity |
| Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000342016 | Q86X95 | 0 | 10 | 288_299 | 24.0 | 451.0 | Compositional bias | Basic residues |
| Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000342016 | Q86X95 | 0 | 10 | 305_324 | 24.0 | 451.0 | Compositional bias | Basic and acidic residues |
| Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000342016 | Q86X95 | 0 | 10 | 331_358 | 24.0 | 451.0 | Compositional bias | Basic and acidic residues |
| Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000342016 | Q86X95 | 0 | 10 | 367_387 | 24.0 | 451.0 | Compositional bias | Basic and acidic residues |
| Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000342016 | Q86X95 | 0 | 10 | 411_440 | 24.0 | 451.0 | Compositional bias | Basic and acidic residues |
| Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000342016 | Q86X95 | 0 | 10 | 78_93 | 24.0 | 451.0 | Compositional bias | Basic and acidic residues |
| Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000342016 | Q86X95 | 0 | 10 | 235_245 | 24.0 | 451.0 | Motif | Nuclear localization signal |
| Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000342016 | Q86X95 | 0 | 10 | 291_298 | 24.0 | 451.0 | Motif | Nuclear localization signal |
| Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000342016 | Q86X95 | 0 | 10 | 218_450 | 24.0 | 451.0 | Region | Disordered |
| Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000342016 | Q86X95 | 0 | 10 | 72_93 | 24.0 | 451.0 | Region | Disordered |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | Q9UPQ3 | 9 | 18 | 422_449 | 350.0 | 858.0 | Compositional bias | Polar residues |
| Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | Q9UPQ3 | 9 | 18 | 504_514 | 350.0 | 858.0 | Compositional bias | Low complexity |
| Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | Q9UPQ3 | 9 | 18 | 524_534 | 350.0 | 858.0 | Compositional bias | Basic residues |
| Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | Q9UPQ3 | 9 | 18 | 346_588 | 350.0 | 858.0 | Domain | PH |
| Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | Q9UPQ3 | 9 | 18 | 609_729 | 350.0 | 858.0 | Domain | Arf-GAP |
| Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | Q9UPQ3 | 9 | 18 | 406_449 | 350.0 | 858.0 | Region | Disordered |
| Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | Q9UPQ3 | 9 | 18 | 496_547 | 350.0 | 858.0 | Region | Disordered |
| Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | Q9UPQ3 | 9 | 18 | 768_797 | 350.0 | 858.0 | Repeat | Note=ANK 1 |
| Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | Q9UPQ3 | 9 | 18 | 801_830 | 350.0 | 858.0 | Repeat | Note=ANK 2 |
| Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | Q9UPQ3 | 9 | 18 | 624_647 | 350.0 | 858.0 | Zinc finger | C4-type |
| - Retained PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Fusion Transcript Sequence for AGAP1_CIR1 |
| In-frame Fusion Transcript Sequences. |
>AGAP1_CIR1_ENST00000304032_ENST00000342016_236715975_175252507 length=3386nt Breakpoint=1630nt CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGC CCAGGGGTCGGCCCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCC GCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCT GGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATGCCTT CGTGAACAGCCAGGAATGGACGCTGAGTCGATCTGTCCCGGAGCTCAAAGTGGGAATTGTGGGTAACTTGGCCAGCGGCAAGTCTGCCCTGGTGCACCGGTACCTGACGGGCACATATGTCCAGGAGGAGTCTCCGGAAGGTGGCAGGTT CAAGAAAGAGATTGTCGTTGATGGACAGAGCTATCTGCTGCTGATCAGAGATGAAGGGGGCCCCCCGGAGGCGCAGTTTGCCATGTGGGTGGACGCTGTTATATTTGTCTTCAGCTTGGAGGATGAAATAAGTTTCCAGACCGTTTACCA CTACTACAGTCGAATGGCCAACTATCGGAACACGAGCGAGATTCCTCTGGTTCTGGTGGGAACCCAGGATGCCATAAGTTCTGCTAACCCGAGGGTCATCGATGACGCCAGGGCGAGGAAGCTCTCCAACGACCTGAAACGGTGCACGTA CTACGAGACGTGTGCTACATACGGGCTGAATGTGGAGAGGGTCTTCCAGGACGTTGCCCAGAAGATTGTTGCCACAAGGAAGAAGCAGCAGCTGTCCATAGGACCCTGCAAGTCGCTACCTAATTCTCCCAGCCATTCCTCCGTCTGTTC CGCGCAGGTGTCTGCCGTGCACATCAGCCAGACAAGTAATGGAGGTGGGAGTTTAAGCGACTATTCCTCCTCCGTTCCATCGACTCCCAGCACCAGCCAGAAGGAACTTCGGATCGATGTTCCTCCCACTGCCAACACGCCCACGCCCGT TCGCAAGCAGTCTAAGCGCCGGTCCAACCTGTTCACCTCTCGGAAAGGGAGCGACCCAGACAAAGAGAAGAAAGGCCTGGAGAGTCGTGCGGACAGCATTGGGAGCGGCCGAGCCATCCCAATTAAACAGGTATGGATGGCAGAACAGAA AATATCATATGATAAGAAGAAACAAGAAGAATTGATGCAGCAATATCTTAAAGAACAAGAATCATATGATAATAGATTGCTTATGGGAGATGAACGTGTAAAGAATGGCCTTAATTTCATGTATGAAGCCCCACCAGGAGCTAAAAAAGA AAACAAAGAGAAAGAAGAAACAGAAGGAGAGACCGAATACAAATTTGAATGGCAGAAAGGAGCCCCACGAGAAAAATATGCCAAAGATGACATGAACATCAGAGATCAGCCCTTTGGTATTCAGGTTCGAAATGTGAGGTGCATTAAATG TCACAAATGGGGTCATGTCAACACAGATCGAGAATGTCCTTTGTTTGGTCTTTCTGGAATCAATGCAAGTTCGGTTCCCACTGATGGCTCAGGGCCATCGATGCACCCCTCGGAGCTAATAGCGGAGATGAGAAACAGTGGGTTTGCACT GAAACGAAATGTACTGGGGAGAAACTTGACCGCAAATGATCCATCACAGGAGTATGTTGCAAGTGAGGGTGAAGAAGATCCAGAAGTTGAATTTTTAAAGTCACTAACAACCAAACAAAAACAGAAACTTCTCAGGAAATTAGATCGACT GGAGAAGAAAAAAAAGAAAAAAGATAGAAAAAAGAAAAAGTTTCAGAAGAGCAGAAGTAAACACAAAAAACATAAGTCCTCTTCTTCCTCATCTTCCTCCTCCTCCTCCTCTTCCTCTACTGAGACTTCAGAAAGCAGTAGTGAGAGTGA GAGTAACAATAAAGAAAAAAAAATACAAAGGAAGAAAAGAAAGAAAAACAAGTGTTCAGGGCATAACAACAGTGATTCTGAAGAGAAGGACAAGTCTAAGAAGAGAAAGCTTCATGAAGAACTTTCTAGCAGTCACCATAACCGGGAAAA AGCCAAGGAAAAGCCCAGGTTCTTAAAACACGAGAGTTCTAGGGAGGACAGCAAATGGAGCCATTCTGATTCTGACAAAAAGTCCAGAACCCATAAACATAGCCCAGAGAAGAGAGGCTCTGAAAGAAAGGAGGGGAGCAGCAGAAGCCA CGGCAGGGAGGAAAGGAGCCGGAGAAGCCGGAGCAGAAGTCCTGGTAGTTACAAGCAAAGGGAGACAAGGAAACGGGCACAGCGAAATCCTGGTGAAGAGCAAAGCAGAAGAAATGACAGCAGAAGCCATGGCACAGACTTGTATAGAGG AGAAAAAATGTACAGAGAGCACCCAGGAGGTACACATACTAAAGTGACACAAAGAGAATGAAGCAGAAGTAGAGAAGAAAGACTGTATGTGACAATTACCTGGGAATAAAAATATCTCCACTTTTTTATTGAATACCTTTAGCAAGGGGT AAATTATGTACTGTTGTCTTTCTAATAAAAAAGCTCAATTTTAATTTTTCATCTCTAGACTGTCAATTCAAGTACAAAACTACATGAGTACTATAAGAATGAATTTTGCAAATATTTGTAAGTAAGCTATTTTGGGGCTGTGGAAATATT TTCTGTTGGTAACTGTTTCTTGTTCCCCATACCAGATAAAAACCGCATATAACTCTGTGACATTTTCTTTGTTCTGAAACATCATTAAAAGAATGACAGTACATTGAATGGGTATAATTTACTTTTTTCAATTCAAATTTGTTATTCTAG GATTTGAATTTGCTTGAAGTGAATTGTAATAATTATTCAAATTCATTAGTATAAATTAAGGATTAATAAATCTTTAAGACTTTTAA >AGAP1_CIR1_ENST00000304032_ENST00000362053_236715975_175252507 length=3284nt Breakpoint=1630nt CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGC CCAGGGGTCGGCCCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCC GCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCT GGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATGCCTT CGTGAACAGCCAGGAATGGACGCTGAGTCGATCTGTCCCGGAGCTCAAAGTGGGAATTGTGGGTAACTTGGCCAGCGGCAAGTCTGCCCTGGTGCACCGGTACCTGACGGGCACATATGTCCAGGAGGAGTCTCCGGAAGGTGGCAGGTT CAAGAAAGAGATTGTCGTTGATGGACAGAGCTATCTGCTGCTGATCAGAGATGAAGGGGGCCCCCCGGAGGCGCAGTTTGCCATGTGGGTGGACGCTGTTATATTTGTCTTCAGCTTGGAGGATGAAATAAGTTTCCAGACCGTTTACCA CTACTACAGTCGAATGGCCAACTATCGGAACACGAGCGAGATTCCTCTGGTTCTGGTGGGAACCCAGGATGCCATAAGTTCTGCTAACCCGAGGGTCATCGATGACGCCAGGGCGAGGAAGCTCTCCAACGACCTGAAACGGTGCACGTA CTACGAGACGTGTGCTACATACGGGCTGAATGTGGAGAGGGTCTTCCAGGACGTTGCCCAGAAGATTGTTGCCACAAGGAAGAAGCAGCAGCTGTCCATAGGACCCTGCAAGTCGCTACCTAATTCTCCCAGCCATTCCTCCGTCTGTTC CGCGCAGGTGTCTGCCGTGCACATCAGCCAGACAAGTAATGGAGGTGGGAGTTTAAGCGACTATTCCTCCTCCGTTCCATCGACTCCCAGCACCAGCCAGAAGGAACTTCGGATCGATGTTCCTCCCACTGCCAACACGCCCACGCCCGT TCGCAAGCAGTCTAAGCGCCGGTCCAACCTGTTCACCTCTCGGAAAGGGAGCGACCCAGACAAAGAGAAGAAAGGCCTGGAGAGTCGTGCGGACAGCATTGGGAGCGGCCGAGCCATCCCAATTAAACAGGTATGGATGGCAGAACAGAA AATATCATATGATAAGAAGAAACAAGAAGAATTGATGCAGCAATATCTTAAAGAACAAGAATCATATGATAATAGATTGCTTATGGGAGATGAACGTGTAAAGAATGGCCTTAATTTCATGTATGAAGCCCCACCAGGAGCTAAAAAAGA AAACAAAGAGAAAGAAGAAACAGAAGGAGAGACCGAATACAAATTTGAATGGCAGAAAGGAGCCCCACGAGAAAAATATGCCAAAGATGACATGAACATCAGAGATCAGCCCTTTGGTATTCAGGTTCGAAATGTGAGGTGCATTAAATG TCACAAATGGGGTCATGTCAACACAGATCGAGAATGTCCTTTGTTTGGTCTTTCTGGAATCAATGCAAGTTCGGTTCCCACTGATGGCTCAGATGCTGTGTTACAAATTGAAGGTTTCTGGGCCATCGATGCACCCCTCGGAGCTAATAG CGGAGATGAGAAACAGTGGGTTTGCACTGAAACGAAATGTACTGGGGAGAAACTTGACCGCAAATGATCCATCACAGGAGTATGTTGCAAGTGAGGGTGAAGAAGATCCAGAAGTTGAATTTTTAAAGTCACTAACAACCAAACAAAAAC AGAAACTTCTCAGGAAATTAGATCGACTGGAGAAGAAAAAAAAGAAAAAAGATAGAAAAAAGAAAAAGTTTCAGAAGAGCAGAAGTAAACACAAAAAACATAAGTCCTCTTCTTCCTCATCTTCCTCCTCCTCCTCCTCTTCCTCTACTG AGACTTCAGAAAGCAGTAGTGAGAGTGAGAGTAACAATAAAGAAAAAAAAATACAAAGGAAGAAAAGAAAGAAAAACAAGTGTTCAGGGCATAACAACAGTGATTCTGAAGAGAAGGACAAGTCTAAGAAGAGAAAGCTTCATGAAGAAC TTTCTAGCAGTCACCATAACCGGGAAAAAGCCAAGGAAAAGCCCAGGTTCTTAAAACACGAGAGTTCTAGGGAGGACAGCAAATGGAGCCATTCTGATTCTGACAAAAAGTCCAGAACCCATAAACATAGCCCAGAGAAGAGAGGCTCTG AAAGAAAGGAGGGGAGCAGCAGAAGCCACGGCAGGGAGGAAAGGAGCCGGAGAAGCCGGAGCAGAAGTCCTGGTAGTTACAAGCAAAGGGAGACAAGGAAACGGGCACAGCGAAATCCTGGTGAAGAGCAAAGCAGAAGAAATGACAGCA GAAGCCATGGCACAGACTTGTATAGAGGAGAAAAAATGTACAGAGAGCACCCAGGAGGTACACATACTAAAGTGACACAAAGAGAATGAAGCAGAAGTAGAGAAGAAAGACTGTATGTGACAATTACCTGGGAATAAAAATATCTCCACT TTTTTATTGAATACCTTTAGCAAGGGGTAAATTATGTACTGTTGTCTTTCTAATAAAAAAGCTCAATTTTAATTTTTCATCTCTAGACTGTCAATTCAAGTACAAAACTACATGAGTACTATAAGAATGAATTTTGCAAATATTTGTAAG TAAGCTATTTTGGGGCTGTGGAAATATTTTCTGTTGGTAACTGTTTCTTGTTCCCCATACCAGATAAAAACCGCATATAACTCTGTGACATTTTCTTTGTTCTGAAACATCATTAAAAGAATGACAGTACATTG >AGAP1_CIR1_ENST00000336665_ENST00000342016_236715975_175252507 length=3386nt Breakpoint=1630nt CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGC CCAGGGGTCGGCCCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCC GCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCT GGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATGCCTT CGTGAACAGCCAGGAATGGACGCTGAGTCGATCTGTCCCGGAGCTCAAAGTGGGAATTGTGGGTAACTTGGCCAGCGGCAAGTCTGCCCTGGTGCACCGGTACCTGACGGGCACATATGTCCAGGAGGAGTCTCCGGAAGGTGGCAGGTT CAAGAAAGAGATTGTCGTTGATGGACAGAGCTATCTGCTGCTGATCAGAGATGAAGGGGGCCCCCCGGAGGCGCAGTTTGCCATGTGGGTGGACGCTGTTATATTTGTCTTCAGCTTGGAGGATGAAATAAGTTTCCAGACCGTTTACCA CTACTACAGTCGAATGGCCAACTATCGGAACACGAGCGAGATTCCTCTGGTTCTGGTGGGAACCCAGGATGCCATAAGTTCTGCTAACCCGAGGGTCATCGATGACGCCAGGGCGAGGAAGCTCTCCAACGACCTGAAACGGTGCACGTA CTACGAGACGTGTGCTACATACGGGCTGAATGTGGAGAGGGTCTTCCAGGACGTTGCCCAGAAGATTGTTGCCACAAGGAAGAAGCAGCAGCTGTCCATAGGACCCTGCAAGTCGCTACCTAATTCTCCCAGCCATTCCTCCGTCTGTTC CGCGCAGGTGTCTGCCGTGCACATCAGCCAGACAAGTAATGGAGGTGGGAGTTTAAGCGACTATTCCTCCTCCGTTCCATCGACTCCCAGCACCAGCCAGAAGGAACTTCGGATCGATGTTCCTCCCACTGCCAACACGCCCACGCCCGT TCGCAAGCAGTCTAAGCGCCGGTCCAACCTGTTCACCTCTCGGAAAGGGAGCGACCCAGACAAAGAGAAGAAAGGCCTGGAGAGTCGTGCGGACAGCATTGGGAGCGGCCGAGCCATCCCAATTAAACAGGTATGGATGGCAGAACAGAA AATATCATATGATAAGAAGAAACAAGAAGAATTGATGCAGCAATATCTTAAAGAACAAGAATCATATGATAATAGATTGCTTATGGGAGATGAACGTGTAAAGAATGGCCTTAATTTCATGTATGAAGCCCCACCAGGAGCTAAAAAAGA AAACAAAGAGAAAGAAGAAACAGAAGGAGAGACCGAATACAAATTTGAATGGCAGAAAGGAGCCCCACGAGAAAAATATGCCAAAGATGACATGAACATCAGAGATCAGCCCTTTGGTATTCAGGTTCGAAATGTGAGGTGCATTAAATG TCACAAATGGGGTCATGTCAACACAGATCGAGAATGTCCTTTGTTTGGTCTTTCTGGAATCAATGCAAGTTCGGTTCCCACTGATGGCTCAGGGCCATCGATGCACCCCTCGGAGCTAATAGCGGAGATGAGAAACAGTGGGTTTGCACT GAAACGAAATGTACTGGGGAGAAACTTGACCGCAAATGATCCATCACAGGAGTATGTTGCAAGTGAGGGTGAAGAAGATCCAGAAGTTGAATTTTTAAAGTCACTAACAACCAAACAAAAACAGAAACTTCTCAGGAAATTAGATCGACT GGAGAAGAAAAAAAAGAAAAAAGATAGAAAAAAGAAAAAGTTTCAGAAGAGCAGAAGTAAACACAAAAAACATAAGTCCTCTTCTTCCTCATCTTCCTCCTCCTCCTCCTCTTCCTCTACTGAGACTTCAGAAAGCAGTAGTGAGAGTGA GAGTAACAATAAAGAAAAAAAAATACAAAGGAAGAAAAGAAAGAAAAACAAGTGTTCAGGGCATAACAACAGTGATTCTGAAGAGAAGGACAAGTCTAAGAAGAGAAAGCTTCATGAAGAACTTTCTAGCAGTCACCATAACCGGGAAAA AGCCAAGGAAAAGCCCAGGTTCTTAAAACACGAGAGTTCTAGGGAGGACAGCAAATGGAGCCATTCTGATTCTGACAAAAAGTCCAGAACCCATAAACATAGCCCAGAGAAGAGAGGCTCTGAAAGAAAGGAGGGGAGCAGCAGAAGCCA CGGCAGGGAGGAAAGGAGCCGGAGAAGCCGGAGCAGAAGTCCTGGTAGTTACAAGCAAAGGGAGACAAGGAAACGGGCACAGCGAAATCCTGGTGAAGAGCAAAGCAGAAGAAATGACAGCAGAAGCCATGGCACAGACTTGTATAGAGG AGAAAAAATGTACAGAGAGCACCCAGGAGGTACACATACTAAAGTGACACAAAGAGAATGAAGCAGAAGTAGAGAAGAAAGACTGTATGTGACAATTACCTGGGAATAAAAATATCTCCACTTTTTTATTGAATACCTTTAGCAAGGGGT AAATTATGTACTGTTGTCTTTCTAATAAAAAAGCTCAATTTTAATTTTTCATCTCTAGACTGTCAATTCAAGTACAAAACTACATGAGTACTATAAGAATGAATTTTGCAAATATTTGTAAGTAAGCTATTTTGGGGCTGTGGAAATATT TTCTGTTGGTAACTGTTTCTTGTTCCCCATACCAGATAAAAACCGCATATAACTCTGTGACATTTTCTTTGTTCTGAAACATCATTAAAAGAATGACAGTACATTGAATGGGTATAATTTACTTTTTTCAATTCAAATTTGTTATTCTAG GATTTGAATTTGCTTGAAGTGAATTGTAATAATTATTCAAATTCATTAGTATAAATTAAGGATTAATAAATCTTTAAGACTTTTAA >AGAP1_CIR1_ENST00000336665_ENST00000362053_236715975_175252507 length=3284nt Breakpoint=1630nt CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGC CCAGGGGTCGGCCCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCC GCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCT GGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATGCCTT CGTGAACAGCCAGGAATGGACGCTGAGTCGATCTGTCCCGGAGCTCAAAGTGGGAATTGTGGGTAACTTGGCCAGCGGCAAGTCTGCCCTGGTGCACCGGTACCTGACGGGCACATATGTCCAGGAGGAGTCTCCGGAAGGTGGCAGGTT CAAGAAAGAGATTGTCGTTGATGGACAGAGCTATCTGCTGCTGATCAGAGATGAAGGGGGCCCCCCGGAGGCGCAGTTTGCCATGTGGGTGGACGCTGTTATATTTGTCTTCAGCTTGGAGGATGAAATAAGTTTCCAGACCGTTTACCA CTACTACAGTCGAATGGCCAACTATCGGAACACGAGCGAGATTCCTCTGGTTCTGGTGGGAACCCAGGATGCCATAAGTTCTGCTAACCCGAGGGTCATCGATGACGCCAGGGCGAGGAAGCTCTCCAACGACCTGAAACGGTGCACGTA CTACGAGACGTGTGCTACATACGGGCTGAATGTGGAGAGGGTCTTCCAGGACGTTGCCCAGAAGATTGTTGCCACAAGGAAGAAGCAGCAGCTGTCCATAGGACCCTGCAAGTCGCTACCTAATTCTCCCAGCCATTCCTCCGTCTGTTC CGCGCAGGTGTCTGCCGTGCACATCAGCCAGACAAGTAATGGAGGTGGGAGTTTAAGCGACTATTCCTCCTCCGTTCCATCGACTCCCAGCACCAGCCAGAAGGAACTTCGGATCGATGTTCCTCCCACTGCCAACACGCCCACGCCCGT TCGCAAGCAGTCTAAGCGCCGGTCCAACCTGTTCACCTCTCGGAAAGGGAGCGACCCAGACAAAGAGAAGAAAGGCCTGGAGAGTCGTGCGGACAGCATTGGGAGCGGCCGAGCCATCCCAATTAAACAGGTATGGATGGCAGAACAGAA AATATCATATGATAAGAAGAAACAAGAAGAATTGATGCAGCAATATCTTAAAGAACAAGAATCATATGATAATAGATTGCTTATGGGAGATGAACGTGTAAAGAATGGCCTTAATTTCATGTATGAAGCCCCACCAGGAGCTAAAAAAGA AAACAAAGAGAAAGAAGAAACAGAAGGAGAGACCGAATACAAATTTGAATGGCAGAAAGGAGCCCCACGAGAAAAATATGCCAAAGATGACATGAACATCAGAGATCAGCCCTTTGGTATTCAGGTTCGAAATGTGAGGTGCATTAAATG TCACAAATGGGGTCATGTCAACACAGATCGAGAATGTCCTTTGTTTGGTCTTTCTGGAATCAATGCAAGTTCGGTTCCCACTGATGGCTCAGATGCTGTGTTACAAATTGAAGGTTTCTGGGCCATCGATGCACCCCTCGGAGCTAATAG CGGAGATGAGAAACAGTGGGTTTGCACTGAAACGAAATGTACTGGGGAGAAACTTGACCGCAAATGATCCATCACAGGAGTATGTTGCAAGTGAGGGTGAAGAAGATCCAGAAGTTGAATTTTTAAAGTCACTAACAACCAAACAAAAAC AGAAACTTCTCAGGAAATTAGATCGACTGGAGAAGAAAAAAAAGAAAAAAGATAGAAAAAAGAAAAAGTTTCAGAAGAGCAGAAGTAAACACAAAAAACATAAGTCCTCTTCTTCCTCATCTTCCTCCTCCTCCTCCTCTTCCTCTACTG AGACTTCAGAAAGCAGTAGTGAGAGTGAGAGTAACAATAAAGAAAAAAAAATACAAAGGAAGAAAAGAAAGAAAAACAAGTGTTCAGGGCATAACAACAGTGATTCTGAAGAGAAGGACAAGTCTAAGAAGAGAAAGCTTCATGAAGAAC TTTCTAGCAGTCACCATAACCGGGAAAAAGCCAAGGAAAAGCCCAGGTTCTTAAAACACGAGAGTTCTAGGGAGGACAGCAAATGGAGCCATTCTGATTCTGACAAAAAGTCCAGAACCCATAAACATAGCCCAGAGAAGAGAGGCTCTG AAAGAAAGGAGGGGAGCAGCAGAAGCCACGGCAGGGAGGAAAGGAGCCGGAGAAGCCGGAGCAGAAGTCCTGGTAGTTACAAGCAAAGGGAGACAAGGAAACGGGCACAGCGAAATCCTGGTGAAGAGCAAAGCAGAAGAAATGACAGCA GAAGCCATGGCACAGACTTGTATAGAGGAGAAAAAATGTACAGAGAGCACCCAGGAGGTACACATACTAAAGTGACACAAAGAGAATGAAGCAGAAGTAGAGAAGAAAGACTGTATGTGACAATTACCTGGGAATAAAAATATCTCCACT TTTTTATTGAATACCTTTAGCAAGGGGTAAATTATGTACTGTTGTCTTTCTAATAAAAAAGCTCAATTTTAATTTTTCATCTCTAGACTGTCAATTCAAGTACAAAACTACATGAGTACTATAAGAATGAATTTTGCAAATATTTGTAAG TAAGCTATTTTGGGGCTGTGGAAATATTTTCTGTTGGTAACTGTTTCTTGTTCCCCATACCAGATAAAAACCGCATATAACTCTGTGACATTTTCTTTGTTCTGAAACATCATTAAAAGAATGACAGTACATTG >AGAP1_CIR1_ENST00000409457_ENST00000342016_236715975_175252507 length=3404nt Breakpoint=1648nt GGCGCTCGGAGCGGGCTCCGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGA GCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGCAAGCCTCCTTCG GGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCC GCGCCTTTCTTCTCGCGCCTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCAT GAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCAT CGCCATCGAAGATGCCTTCGTGAACAGCCAGGAATGGACGCTGAGTCGATCTGTCCCGGAGCTCAAAGTGGGAATTGTGGGTAACTTGGCCAGCGGCAAGTCTGCCCTGGTGCACCGGTACCTGACGGGCACATATGTCCAGGAGGAGTC TCCGGAAGGTGGCAGGTTCAAGAAAGAGATTGTCGTTGATGGACAGAGCTATCTGCTGCTGATCAGAGATGAAGGGGGCCCCCCGGAGGCGCAGTTTGCCATGTGGGTGGACGCTGTTATATTTGTCTTCAGCTTGGAGGATGAAATAAG TTTCCAGACCGTTTACCACTACTACAGTCGAATGGCCAACTATCGGAACACGAGCGAGATTCCTCTGGTTCTGGTGGGAACCCAGGATGCCATAAGTTCTGCTAACCCGAGGGTCATCGATGACGCCAGGGCGAGGAAGCTCTCCAACGA CCTGAAACGGTGCACGTACTACGAGACGTGTGCTACATACGGGCTGAATGTGGAGAGGGTCTTCCAGGACGTTGCCCAGAAGATTGTTGCCACAAGGAAGAAGCAGCAGCTGTCCATAGGACCCTGCAAGTCGCTACCTAATTCTCCCAG CCATTCCTCCGTCTGTTCCGCGCAGGTGTCTGCCGTGCACATCAGCCAGACAAGTAATGGAGGTGGGAGTTTAAGCGACTATTCCTCCTCCGTTCCATCGACTCCCAGCACCAGCCAGAAGGAACTTCGGATCGATGTTCCTCCCACTGC CAACACGCCCACGCCCGTTCGCAAGCAGTCTAAGCGCCGGTCCAACCTGTTCACCTCTCGGAAAGGGAGCGACCCAGACAAAGAGAAGAAAGGCCTGGAGAGTCGTGCGGACAGCATTGGGAGCGGCCGAGCCATCCCAATTAAACAGGT ATGGATGGCAGAACAGAAAATATCATATGATAAGAAGAAACAAGAAGAATTGATGCAGCAATATCTTAAAGAACAAGAATCATATGATAATAGATTGCTTATGGGAGATGAACGTGTAAAGAATGGCCTTAATTTCATGTATGAAGCCCC ACCAGGAGCTAAAAAAGAAAACAAAGAGAAAGAAGAAACAGAAGGAGAGACCGAATACAAATTTGAATGGCAGAAAGGAGCCCCACGAGAAAAATATGCCAAAGATGACATGAACATCAGAGATCAGCCCTTTGGTATTCAGGTTCGAAA TGTGAGGTGCATTAAATGTCACAAATGGGGTCATGTCAACACAGATCGAGAATGTCCTTTGTTTGGTCTTTCTGGAATCAATGCAAGTTCGGTTCCCACTGATGGCTCAGGGCCATCGATGCACCCCTCGGAGCTAATAGCGGAGATGAG AAACAGTGGGTTTGCACTGAAACGAAATGTACTGGGGAGAAACTTGACCGCAAATGATCCATCACAGGAGTATGTTGCAAGTGAGGGTGAAGAAGATCCAGAAGTTGAATTTTTAAAGTCACTAACAACCAAACAAAAACAGAAACTTCT CAGGAAATTAGATCGACTGGAGAAGAAAAAAAAGAAAAAAGATAGAAAAAAGAAAAAGTTTCAGAAGAGCAGAAGTAAACACAAAAAACATAAGTCCTCTTCTTCCTCATCTTCCTCCTCCTCCTCCTCTTCCTCTACTGAGACTTCAGA AAGCAGTAGTGAGAGTGAGAGTAACAATAAAGAAAAAAAAATACAAAGGAAGAAAAGAAAGAAAAACAAGTGTTCAGGGCATAACAACAGTGATTCTGAAGAGAAGGACAAGTCTAAGAAGAGAAAGCTTCATGAAGAACTTTCTAGCAG TCACCATAACCGGGAAAAAGCCAAGGAAAAGCCCAGGTTCTTAAAACACGAGAGTTCTAGGGAGGACAGCAAATGGAGCCATTCTGATTCTGACAAAAAGTCCAGAACCCATAAACATAGCCCAGAGAAGAGAGGCTCTGAAAGAAAGGA GGGGAGCAGCAGAAGCCACGGCAGGGAGGAAAGGAGCCGGAGAAGCCGGAGCAGAAGTCCTGGTAGTTACAAGCAAAGGGAGACAAGGAAACGGGCACAGCGAAATCCTGGTGAAGAGCAAAGCAGAAGAAATGACAGCAGAAGCCATGG CACAGACTTGTATAGAGGAGAAAAAATGTACAGAGAGCACCCAGGAGGTACACATACTAAAGTGACACAAAGAGAATGAAGCAGAAGTAGAGAAGAAAGACTGTATGTGACAATTACCTGGGAATAAAAATATCTCCACTTTTTTATTGA ATACCTTTAGCAAGGGGTAAATTATGTACTGTTGTCTTTCTAATAAAAAAGCTCAATTTTAATTTTTCATCTCTAGACTGTCAATTCAAGTACAAAACTACATGAGTACTATAAGAATGAATTTTGCAAATATTTGTAAGTAAGCTATTT TGGGGCTGTGGAAATATTTTCTGTTGGTAACTGTTTCTTGTTCCCCATACCAGATAAAAACCGCATATAACTCTGTGACATTTTCTTTGTTCTGAAACATCATTAAAAGAATGACAGTACATTGAATGGGTATAATTTACTTTTTTCAAT TCAAATTTGTTATTCTAGGATTTGAATTTGCTTGAAGTGAATTGTAATAATTATTCAAATTCATTAGTATAAATTAAGGATTAATAAATCTTTAAGACTTTTAA >AGAP1_CIR1_ENST00000409457_ENST00000362053_236715975_175252507 length=3302nt Breakpoint=1648nt GGCGCTCGGAGCGGGCTCCGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGA GCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGCAAGCCTCCTTCG GGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCC GCGCCTTTCTTCTCGCGCCTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCAT GAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCAT CGCCATCGAAGATGCCTTCGTGAACAGCCAGGAATGGACGCTGAGTCGATCTGTCCCGGAGCTCAAAGTGGGAATTGTGGGTAACTTGGCCAGCGGCAAGTCTGCCCTGGTGCACCGGTACCTGACGGGCACATATGTCCAGGAGGAGTC TCCGGAAGGTGGCAGGTTCAAGAAAGAGATTGTCGTTGATGGACAGAGCTATCTGCTGCTGATCAGAGATGAAGGGGGCCCCCCGGAGGCGCAGTTTGCCATGTGGGTGGACGCTGTTATATTTGTCTTCAGCTTGGAGGATGAAATAAG TTTCCAGACCGTTTACCACTACTACAGTCGAATGGCCAACTATCGGAACACGAGCGAGATTCCTCTGGTTCTGGTGGGAACCCAGGATGCCATAAGTTCTGCTAACCCGAGGGTCATCGATGACGCCAGGGCGAGGAAGCTCTCCAACGA CCTGAAACGGTGCACGTACTACGAGACGTGTGCTACATACGGGCTGAATGTGGAGAGGGTCTTCCAGGACGTTGCCCAGAAGATTGTTGCCACAAGGAAGAAGCAGCAGCTGTCCATAGGACCCTGCAAGTCGCTACCTAATTCTCCCAG CCATTCCTCCGTCTGTTCCGCGCAGGTGTCTGCCGTGCACATCAGCCAGACAAGTAATGGAGGTGGGAGTTTAAGCGACTATTCCTCCTCCGTTCCATCGACTCCCAGCACCAGCCAGAAGGAACTTCGGATCGATGTTCCTCCCACTGC CAACACGCCCACGCCCGTTCGCAAGCAGTCTAAGCGCCGGTCCAACCTGTTCACCTCTCGGAAAGGGAGCGACCCAGACAAAGAGAAGAAAGGCCTGGAGAGTCGTGCGGACAGCATTGGGAGCGGCCGAGCCATCCCAATTAAACAGGT ATGGATGGCAGAACAGAAAATATCATATGATAAGAAGAAACAAGAAGAATTGATGCAGCAATATCTTAAAGAACAAGAATCATATGATAATAGATTGCTTATGGGAGATGAACGTGTAAAGAATGGCCTTAATTTCATGTATGAAGCCCC ACCAGGAGCTAAAAAAGAAAACAAAGAGAAAGAAGAAACAGAAGGAGAGACCGAATACAAATTTGAATGGCAGAAAGGAGCCCCACGAGAAAAATATGCCAAAGATGACATGAACATCAGAGATCAGCCCTTTGGTATTCAGGTTCGAAA TGTGAGGTGCATTAAATGTCACAAATGGGGTCATGTCAACACAGATCGAGAATGTCCTTTGTTTGGTCTTTCTGGAATCAATGCAAGTTCGGTTCCCACTGATGGCTCAGATGCTGTGTTACAAATTGAAGGTTTCTGGGCCATCGATGC ACCCCTCGGAGCTAATAGCGGAGATGAGAAACAGTGGGTTTGCACTGAAACGAAATGTACTGGGGAGAAACTTGACCGCAAATGATCCATCACAGGAGTATGTTGCAAGTGAGGGTGAAGAAGATCCAGAAGTTGAATTTTTAAAGTCAC TAACAACCAAACAAAAACAGAAACTTCTCAGGAAATTAGATCGACTGGAGAAGAAAAAAAAGAAAAAAGATAGAAAAAAGAAAAAGTTTCAGAAGAGCAGAAGTAAACACAAAAAACATAAGTCCTCTTCTTCCTCATCTTCCTCCTCCT CCTCCTCTTCCTCTACTGAGACTTCAGAAAGCAGTAGTGAGAGTGAGAGTAACAATAAAGAAAAAAAAATACAAAGGAAGAAAAGAAAGAAAAACAAGTGTTCAGGGCATAACAACAGTGATTCTGAAGAGAAGGACAAGTCTAAGAAGA GAAAGCTTCATGAAGAACTTTCTAGCAGTCACCATAACCGGGAAAAAGCCAAGGAAAAGCCCAGGTTCTTAAAACACGAGAGTTCTAGGGAGGACAGCAAATGGAGCCATTCTGATTCTGACAAAAAGTCCAGAACCCATAAACATAGCC CAGAGAAGAGAGGCTCTGAAAGAAAGGAGGGGAGCAGCAGAAGCCACGGCAGGGAGGAAAGGAGCCGGAGAAGCCGGAGCAGAAGTCCTGGTAGTTACAAGCAAAGGGAGACAAGGAAACGGGCACAGCGAAATCCTGGTGAAGAGCAAA GCAGAAGAAATGACAGCAGAAGCCATGGCACAGACTTGTATAGAGGAGAAAAAATGTACAGAGAGCACCCAGGAGGTACACATACTAAAGTGACACAAAGAGAATGAAGCAGAAGTAGAGAAGAAAGACTGTATGTGACAATTACCTGGG AATAAAAATATCTCCACTTTTTTATTGAATACCTTTAGCAAGGGGTAAATTATGTACTGTTGTCTTTCTAATAAAAAAGCTCAATTTTAATTTTTCATCTCTAGACTGTCAATTCAAGTACAAAACTACATGAGTACTATAAGAATGAAT TTTGCAAATATTTGTAAGTAAGCTATTTTGGGGCTGTGGAAATATTTTCTGTTGGTAACTGTTTCTTGTTCCCCATACCAGATAAAAACCGCATATAACTCTGTGACATTTTCTTTGTTCTGAAACATCATTAAAAGAATGACAGTACAT TG >AGAP1_CIR1_ENST00000409538_ENST00000342016_236715975_175252507 length=4097nt Breakpoint=2341nt GCGCGTTTCCATTTTAAACCGCCGCCCGCCGCCCGCCACCCGCCACCCTTCGGCCGCAGCCGGTGCAGCTGTCCGCGCGTCCCGGAGCCCAGGGAGTGGCGGAGGCTGCGGAACCGCCGAGCTGTGCAGCCGGAGCGGGAGGATGCGCAC GGGCCCCGCGTCGTAGACAATGAAGCCGCGGGCGCCGCCGCCTGCCCTGGGCCCTGCGCACCGCGGCCGCACCTGCCGGCGAGAGCGCTCTAGCGCCTGACCGGCCGCCTCGCTTGGCCCCGCCGGCCCATGGCTCGGCGCCCCGGGCCC GGACCCCGGCACTCGGGCGGCGCGGCGCACGGGCCGGCGGGTGCCAGGGGCGCCGTCCCCGCAGCCTGAGTGCGGCCCTCGCGGTCAGCGGGGGGCGTGGGCCACACTCCCGGCCCGCCTGCCCTCCCCGCTTGGCCCGGCGCCCTCCCG GCCCGCGGGCTCGCTGGATGCGGCGGGGCCCCAGCGCGCGGGCGACATGTACTTGTTGGACGGCAGTGGCGAGCCCGCGTCGCCACCCGCGGACGCGATGCCGCGCGGGACGCCCCCCAGAAAGACTGTCTACCGCATCTCCGTGACCAT GGTCAGGAAGGAGCAGCTGGCCGCGCCGGGCTCCGGCGGCCCGGACCCACGCCCGGTTCGGCGGCCCCGGCCCGCGCGCTCCCCGGACGCGCCCGGGAGGCTTGAGGAGGAGGCCGAGGAGGCGGAGGGCGCCGAGGAACCGGAGGGTCC CCGGCCGCGCGCTTGGGATTTCCGCACCTTCCGCACCCGCAGCACCGGGCAGCTGGAACTGGGGCGGCTCCGGCCGTGCGCACGCGGCCTGGAACCCGCGGACCTGGCCGGCAGCGCCCCGGCCGAGGAGGAGGGACGCGGCTCGCCCGC GTCCGGCAGCCCCGACGTGGAGGGGGCCCGGGCCGCGCCCCTGCGGCGGAGCCTGAGCTTCAGGCACTGGAGCGGGCCTGAGGCGCCGCAAGGCCGGACACTGGGCGGCGGAAGGCGCCACAGCAGCTCCGGGAGCCTGGCCTGGGCGCC GTGCGACGAGGCCGCGGCCGGGACCACCCTGGAGCCCGCGACCGCCACGCAGCCCGCCTCGGAGAAGCGCAACACCCTGGACGTGGGCGAGGTGCTCAGCAAGAACGACGCGCTCTCGGACCTGGAGCGTTGGGAACGCAGTAAGAGCAA GAACCGCACGCTGGACAACAGCGACCTGCAGCGGCTGGAGCGCGCGCGGGCGGCGGCCGGGGCCGGCGCGGCCTCGGAGCACCGGCTGCTGCGCTTCTTCAGCGGCATCTTCGCGCGCAGGGACGGGGGCCCGGGCGGCGGGCCCTCGCC ACGGAGCGGAGCCTCGCGGCCACGCGGCTACTTCAGCCTGCGGCGGGCCCCGGCCGAAGCGCACTCGTCCAGCGCCGAGAGCATCGACGGCTCCCCGCGCAGAGATGCCTTCGTGAACAGCCAGGAATGGACGCTGAGTCGATCTGTCCC GGAGCTCAAAGTGGGAATTGTGGGTAACTTGGCCAGCGGCAAGTCTGCCCTGGTGCACCGGTACCTGACGGGCACATATGTCCAGGAGGAGTCTCCGGAAGGTGGCAGGTTCAAGAAAGAGATTGTCGTTGATGGACAGAGCTATCTGCT GCTGATCAGAGATGAAGGGGGCCCCCCGGAGGCGCAGTTTGCCATGTGGGTGGACGCTGTTATATTTGTCTTCAGCTTGGAGGATGAAATAAGTTTCCAGACCGTTTACCACTACTACAGTCGAATGGCCAACTATCGGAACACGAGCGA GATTCCTCTGGTTCTGGTGGGAACCCAGGATGCCATAAGTTCTGCTAACCCGAGGGTCATCGATGACGCCAGGGCGAGGAAGCTCTCCAACGACCTGAAACGGTGCACGTACTACGAGACGTGTGCTACATACGGGCTGAATGTGGAGAG GGTCTTCCAGGACGTTGCCCAGAAGATTGTTGCCACAAGGAAGAAGCAGCAGCTGTCCATAGGACCCTGCAAGTCGCTACCTAATTCTCCCAGCCATTCCTCCGTCTGTTCCGCGCAGGTGTCTGCCGTGCACATCAGCCAGACAAGTAA TGGAGGTGGGAGTTTAAGCGACTATTCCTCCTCCGTTCCATCGACTCCCAGCACCAGCCAGAAGGAACTTCGGATCGATGTTCCTCCCACTGCCAACACGCCCACGCCCGTTCGCAAGCAGTCTAAGCGCCGGTCCAACCTGTTCACCTC TCGGAAAGGGAGCGACCCAGACAAAGAGAAGAAAGGCCTGGAGAGTCGTGCGGACAGCATTGGGAGCGGCCGAGCCATCCCAATTAAACAGGTATGGATGGCAGAACAGAAAATATCATATGATAAGAAGAAACAAGAAGAATTGATGCA GCAATATCTTAAAGAACAAGAATCATATGATAATAGATTGCTTATGGGAGATGAACGTGTAAAGAATGGCCTTAATTTCATGTATGAAGCCCCACCAGGAGCTAAAAAAGAAAACAAAGAGAAAGAAGAAACAGAAGGAGAGACCGAATA CAAATTTGAATGGCAGAAAGGAGCCCCACGAGAAAAATATGCCAAAGATGACATGAACATCAGAGATCAGCCCTTTGGTATTCAGGTTCGAAATGTGAGGTGCATTAAATGTCACAAATGGGGTCATGTCAACACAGATCGAGAATGTCC TTTGTTTGGTCTTTCTGGAATCAATGCAAGTTCGGTTCCCACTGATGGCTCAGGGCCATCGATGCACCCCTCGGAGCTAATAGCGGAGATGAGAAACAGTGGGTTTGCACTGAAACGAAATGTACTGGGGAGAAACTTGACCGCAAATGA TCCATCACAGGAGTATGTTGCAAGTGAGGGTGAAGAAGATCCAGAAGTTGAATTTTTAAAGTCACTAACAACCAAACAAAAACAGAAACTTCTCAGGAAATTAGATCGACTGGAGAAGAAAAAAAAGAAAAAAGATAGAAAAAAGAAAAA GTTTCAGAAGAGCAGAAGTAAACACAAAAAACATAAGTCCTCTTCTTCCTCATCTTCCTCCTCCTCCTCCTCTTCCTCTACTGAGACTTCAGAAAGCAGTAGTGAGAGTGAGAGTAACAATAAAGAAAAAAAAATACAAAGGAAGAAAAG AAAGAAAAACAAGTGTTCAGGGCATAACAACAGTGATTCTGAAGAGAAGGACAAGTCTAAGAAGAGAAAGCTTCATGAAGAACTTTCTAGCAGTCACCATAACCGGGAAAAAGCCAAGGAAAAGCCCAGGTTCTTAAAACACGAGAGTTC TAGGGAGGACAGCAAATGGAGCCATTCTGATTCTGACAAAAAGTCCAGAACCCATAAACATAGCCCAGAGAAGAGAGGCTCTGAAAGAAAGGAGGGGAGCAGCAGAAGCCACGGCAGGGAGGAAAGGAGCCGGAGAAGCCGGAGCAGAAG TCCTGGTAGTTACAAGCAAAGGGAGACAAGGAAACGGGCACAGCGAAATCCTGGTGAAGAGCAAAGCAGAAGAAATGACAGCAGAAGCCATGGCACAGACTTGTATAGAGGAGAAAAAATGTACAGAGAGCACCCAGGAGGTACACATAC TAAAGTGACACAAAGAGAATGAAGCAGAAGTAGAGAAGAAAGACTGTATGTGACAATTACCTGGGAATAAAAATATCTCCACTTTTTTATTGAATACCTTTAGCAAGGGGTAAATTATGTACTGTTGTCTTTCTAATAAAAAAGCTCAAT TTTAATTTTTCATCTCTAGACTGTCAATTCAAGTACAAAACTACATGAGTACTATAAGAATGAATTTTGCAAATATTTGTAAGTAAGCTATTTTGGGGCTGTGGAAATATTTTCTGTTGGTAACTGTTTCTTGTTCCCCATACCAGATAA AAACCGCATATAACTCTGTGACATTTTCTTTGTTCTGAAACATCATTAAAAGAATGACAGTACATTGAATGGGTATAATTTACTTTTTTCAATTCAAATTTGTTATTCTAGGATTTGAATTTGCTTGAAGTGAATTGTAATAATTATTCA AATTCATTAGTATAAATTAAGGATTAATAAATCTTTAAGACTTTTAA >AGAP1_CIR1_ENST00000409538_ENST00000362053_236715975_175252507 length=3995nt Breakpoint=2341nt GCGCGTTTCCATTTTAAACCGCCGCCCGCCGCCCGCCACCCGCCACCCTTCGGCCGCAGCCGGTGCAGCTGTCCGCGCGTCCCGGAGCCCAGGGAGTGGCGGAGGCTGCGGAACCGCCGAGCTGTGCAGCCGGAGCGGGAGGATGCGCAC GGGCCCCGCGTCGTAGACAATGAAGCCGCGGGCGCCGCCGCCTGCCCTGGGCCCTGCGCACCGCGGCCGCACCTGCCGGCGAGAGCGCTCTAGCGCCTGACCGGCCGCCTCGCTTGGCCCCGCCGGCCCATGGCTCGGCGCCCCGGGCCC GGACCCCGGCACTCGGGCGGCGCGGCGCACGGGCCGGCGGGTGCCAGGGGCGCCGTCCCCGCAGCCTGAGTGCGGCCCTCGCGGTCAGCGGGGGGCGTGGGCCACACTCCCGGCCCGCCTGCCCTCCCCGCTTGGCCCGGCGCCCTCCCG GCCCGCGGGCTCGCTGGATGCGGCGGGGCCCCAGCGCGCGGGCGACATGTACTTGTTGGACGGCAGTGGCGAGCCCGCGTCGCCACCCGCGGACGCGATGCCGCGCGGGACGCCCCCCAGAAAGACTGTCTACCGCATCTCCGTGACCAT GGTCAGGAAGGAGCAGCTGGCCGCGCCGGGCTCCGGCGGCCCGGACCCACGCCCGGTTCGGCGGCCCCGGCCCGCGCGCTCCCCGGACGCGCCCGGGAGGCTTGAGGAGGAGGCCGAGGAGGCGGAGGGCGCCGAGGAACCGGAGGGTCC CCGGCCGCGCGCTTGGGATTTCCGCACCTTCCGCACCCGCAGCACCGGGCAGCTGGAACTGGGGCGGCTCCGGCCGTGCGCACGCGGCCTGGAACCCGCGGACCTGGCCGGCAGCGCCCCGGCCGAGGAGGAGGGACGCGGCTCGCCCGC GTCCGGCAGCCCCGACGTGGAGGGGGCCCGGGCCGCGCCCCTGCGGCGGAGCCTGAGCTTCAGGCACTGGAGCGGGCCTGAGGCGCCGCAAGGCCGGACACTGGGCGGCGGAAGGCGCCACAGCAGCTCCGGGAGCCTGGCCTGGGCGCC GTGCGACGAGGCCGCGGCCGGGACCACCCTGGAGCCCGCGACCGCCACGCAGCCCGCCTCGGAGAAGCGCAACACCCTGGACGTGGGCGAGGTGCTCAGCAAGAACGACGCGCTCTCGGACCTGGAGCGTTGGGAACGCAGTAAGAGCAA GAACCGCACGCTGGACAACAGCGACCTGCAGCGGCTGGAGCGCGCGCGGGCGGCGGCCGGGGCCGGCGCGGCCTCGGAGCACCGGCTGCTGCGCTTCTTCAGCGGCATCTTCGCGCGCAGGGACGGGGGCCCGGGCGGCGGGCCCTCGCC ACGGAGCGGAGCCTCGCGGCCACGCGGCTACTTCAGCCTGCGGCGGGCCCCGGCCGAAGCGCACTCGTCCAGCGCCGAGAGCATCGACGGCTCCCCGCGCAGAGATGCCTTCGTGAACAGCCAGGAATGGACGCTGAGTCGATCTGTCCC GGAGCTCAAAGTGGGAATTGTGGGTAACTTGGCCAGCGGCAAGTCTGCCCTGGTGCACCGGTACCTGACGGGCACATATGTCCAGGAGGAGTCTCCGGAAGGTGGCAGGTTCAAGAAAGAGATTGTCGTTGATGGACAGAGCTATCTGCT GCTGATCAGAGATGAAGGGGGCCCCCCGGAGGCGCAGTTTGCCATGTGGGTGGACGCTGTTATATTTGTCTTCAGCTTGGAGGATGAAATAAGTTTCCAGACCGTTTACCACTACTACAGTCGAATGGCCAACTATCGGAACACGAGCGA GATTCCTCTGGTTCTGGTGGGAACCCAGGATGCCATAAGTTCTGCTAACCCGAGGGTCATCGATGACGCCAGGGCGAGGAAGCTCTCCAACGACCTGAAACGGTGCACGTACTACGAGACGTGTGCTACATACGGGCTGAATGTGGAGAG GGTCTTCCAGGACGTTGCCCAGAAGATTGTTGCCACAAGGAAGAAGCAGCAGCTGTCCATAGGACCCTGCAAGTCGCTACCTAATTCTCCCAGCCATTCCTCCGTCTGTTCCGCGCAGGTGTCTGCCGTGCACATCAGCCAGACAAGTAA TGGAGGTGGGAGTTTAAGCGACTATTCCTCCTCCGTTCCATCGACTCCCAGCACCAGCCAGAAGGAACTTCGGATCGATGTTCCTCCCACTGCCAACACGCCCACGCCCGTTCGCAAGCAGTCTAAGCGCCGGTCCAACCTGTTCACCTC TCGGAAAGGGAGCGACCCAGACAAAGAGAAGAAAGGCCTGGAGAGTCGTGCGGACAGCATTGGGAGCGGCCGAGCCATCCCAATTAAACAGGTATGGATGGCAGAACAGAAAATATCATATGATAAGAAGAAACAAGAAGAATTGATGCA GCAATATCTTAAAGAACAAGAATCATATGATAATAGATTGCTTATGGGAGATGAACGTGTAAAGAATGGCCTTAATTTCATGTATGAAGCCCCACCAGGAGCTAAAAAAGAAAACAAAGAGAAAGAAGAAACAGAAGGAGAGACCGAATA CAAATTTGAATGGCAGAAAGGAGCCCCACGAGAAAAATATGCCAAAGATGACATGAACATCAGAGATCAGCCCTTTGGTATTCAGGTTCGAAATGTGAGGTGCATTAAATGTCACAAATGGGGTCATGTCAACACAGATCGAGAATGTCC TTTGTTTGGTCTTTCTGGAATCAATGCAAGTTCGGTTCCCACTGATGGCTCAGATGCTGTGTTACAAATTGAAGGTTTCTGGGCCATCGATGCACCCCTCGGAGCTAATAGCGGAGATGAGAAACAGTGGGTTTGCACTGAAACGAAATG TACTGGGGAGAAACTTGACCGCAAATGATCCATCACAGGAGTATGTTGCAAGTGAGGGTGAAGAAGATCCAGAAGTTGAATTTTTAAAGTCACTAACAACCAAACAAAAACAGAAACTTCTCAGGAAATTAGATCGACTGGAGAAGAAAA AAAAGAAAAAAGATAGAAAAAAGAAAAAGTTTCAGAAGAGCAGAAGTAAACACAAAAAACATAAGTCCTCTTCTTCCTCATCTTCCTCCTCCTCCTCCTCTTCCTCTACTGAGACTTCAGAAAGCAGTAGTGAGAGTGAGAGTAACAATA AAGAAAAAAAAATACAAAGGAAGAAAAGAAAGAAAAACAAGTGTTCAGGGCATAACAACAGTGATTCTGAAGAGAAGGACAAGTCTAAGAAGAGAAAGCTTCATGAAGAACTTTCTAGCAGTCACCATAACCGGGAAAAAGCCAAGGAAA AGCCCAGGTTCTTAAAACACGAGAGTTCTAGGGAGGACAGCAAATGGAGCCATTCTGATTCTGACAAAAAGTCCAGAACCCATAAACATAGCCCAGAGAAGAGAGGCTCTGAAAGAAAGGAGGGGAGCAGCAGAAGCCACGGCAGGGAGG AAAGGAGCCGGAGAAGCCGGAGCAGAAGTCCTGGTAGTTACAAGCAAAGGGAGACAAGGAAACGGGCACAGCGAAATCCTGGTGAAGAGCAAAGCAGAAGAAATGACAGCAGAAGCCATGGCACAGACTTGTATAGAGGAGAAAAAATGT ACAGAGAGCACCCAGGAGGTACACATACTAAAGTGACACAAAGAGAATGAAGCAGAAGTAGAGAAGAAAGACTGTATGTGACAATTACCTGGGAATAAAAATATCTCCACTTTTTTATTGAATACCTTTAGCAAGGGGTAAATTATGTAC TGTTGTCTTTCTAATAAAAAAGCTCAATTTTAATTTTTCATCTCTAGACTGTCAATTCAAGTACAAAACTACATGAGTACTATAAGAATGAATTTTGCAAATATTTGTAAGTAAGCTATTTTGGGGCTGTGGAAATATTTTCTGTTGGTA ACTGTTTCTTGTTCCCCATACCAGATAAAAACCGCATATAACTCTGTGACATTTTCTTTGTTCTGAAACATCATTAAAAGAATGACAGTACATTG >AGAP1_CIR1_ENST00000428334_ENST00000342016_236715975_175252507 length=2344nt Breakpoint=588nt GTTTACCACTACTACAGTCGAATGGCCAACTATCGGAACACGAGCGAGATTCCTCTGGTTCTGGTGGGAACCCAGGATGCCATAAGTTCTGCTAACCCGAGGGTCATCGATGACGCCAGGGCGAGGAAGCTCTCCAACGACCTGAAACGG TGCACGTACTACGAGACGTGTGCTACATACGGGCTGAATGTGGAGAGGGTCTTCCAGGACGTTGCCCAGAAGATTGTTGCCACAAGGAAGAAGCAGCAGCTGTCCATAGGACCCTGCAAGTCGCTACCTAATTCTCCCAGCCATTCCTCC GTCTGTTCCGCGCAGGTGTCTGCCGTGCACATCAGCCAGACAAGTAATGGAGGTGGGAGTTTAAGCGACTATTCCTCCTCCGTTCCATCGACTCCCAGCACCAGCCAGAAGGAACTTCGGATCGATGTTCCTCCCACTGCCAACACGCCC ACGCCCGTTCGCAAGCAGTCTAAGCGCCGGTCCAACCTGTTCACCTCTCGGAAAGGGAGCGACCCAGACAAAGAGAAGAAAGGCCTGGAGAGTCGTGCGGACAGCATTGGGAGCGGCCGAGCCATCCCAATTAAACAGGTATGGATGGCA GAACAGAAAATATCATATGATAAGAAGAAACAAGAAGAATTGATGCAGCAATATCTTAAAGAACAAGAATCATATGATAATAGATTGCTTATGGGAGATGAACGTGTAAAGAATGGCCTTAATTTCATGTATGAAGCCCCACCAGGAGCT AAAAAAGAAAACAAAGAGAAAGAAGAAACAGAAGGAGAGACCGAATACAAATTTGAATGGCAGAAAGGAGCCCCACGAGAAAAATATGCCAAAGATGACATGAACATCAGAGATCAGCCCTTTGGTATTCAGGTTCGAAATGTGAGGTGC ATTAAATGTCACAAATGGGGTCATGTCAACACAGATCGAGAATGTCCTTTGTTTGGTCTTTCTGGAATCAATGCAAGTTCGGTTCCCACTGATGGCTCAGGGCCATCGATGCACCCCTCGGAGCTAATAGCGGAGATGAGAAACAGTGGG TTTGCACTGAAACGAAATGTACTGGGGAGAAACTTGACCGCAAATGATCCATCACAGGAGTATGTTGCAAGTGAGGGTGAAGAAGATCCAGAAGTTGAATTTTTAAAGTCACTAACAACCAAACAAAAACAGAAACTTCTCAGGAAATTA GATCGACTGGAGAAGAAAAAAAAGAAAAAAGATAGAAAAAAGAAAAAGTTTCAGAAGAGCAGAAGTAAACACAAAAAACATAAGTCCTCTTCTTCCTCATCTTCCTCCTCCTCCTCCTCTTCCTCTACTGAGACTTCAGAAAGCAGTAGT GAGAGTGAGAGTAACAATAAAGAAAAAAAAATACAAAGGAAGAAAAGAAAGAAAAACAAGTGTTCAGGGCATAACAACAGTGATTCTGAAGAGAAGGACAAGTCTAAGAAGAGAAAGCTTCATGAAGAACTTTCTAGCAGTCACCATAAC CGGGAAAAAGCCAAGGAAAAGCCCAGGTTCTTAAAACACGAGAGTTCTAGGGAGGACAGCAAATGGAGCCATTCTGATTCTGACAAAAAGTCCAGAACCCATAAACATAGCCCAGAGAAGAGAGGCTCTGAAAGAAAGGAGGGGAGCAGC AGAAGCCACGGCAGGGAGGAAAGGAGCCGGAGAAGCCGGAGCAGAAGTCCTGGTAGTTACAAGCAAAGGGAGACAAGGAAACGGGCACAGCGAAATCCTGGTGAAGAGCAAAGCAGAAGAAATGACAGCAGAAGCCATGGCACAGACTTG TATAGAGGAGAAAAAATGTACAGAGAGCACCCAGGAGGTACACATACTAAAGTGACACAAAGAGAATGAAGCAGAAGTAGAGAAGAAAGACTGTATGTGACAATTACCTGGGAATAAAAATATCTCCACTTTTTTATTGAATACCTTTAG CAAGGGGTAAATTATGTACTGTTGTCTTTCTAATAAAAAAGCTCAATTTTAATTTTTCATCTCTAGACTGTCAATTCAAGTACAAAACTACATGAGTACTATAAGAATGAATTTTGCAAATATTTGTAAGTAAGCTATTTTGGGGCTGTG GAAATATTTTCTGTTGGTAACTGTTTCTTGTTCCCCATACCAGATAAAAACCGCATATAACTCTGTGACATTTTCTTTGTTCTGAAACATCATTAAAAGAATGACAGTACATTGAATGGGTATAATTTACTTTTTTCAATTCAAATTTGT TATTCTAGGATTTGAATTTGCTTGAAGTGAATTGTAATAATTATTCAAATTCATTAGTATAAATTAAGGATTAATAAATCTTTAAGACTTTTAA >AGAP1_CIR1_ENST00000428334_ENST00000362053_236715975_175252507 length=2242nt Breakpoint=588nt GTTTACCACTACTACAGTCGAATGGCCAACTATCGGAACACGAGCGAGATTCCTCTGGTTCTGGTGGGAACCCAGGATGCCATAAGTTCTGCTAACCCGAGGGTCATCGATGACGCCAGGGCGAGGAAGCTCTCCAACGACCTGAAACGG TGCACGTACTACGAGACGTGTGCTACATACGGGCTGAATGTGGAGAGGGTCTTCCAGGACGTTGCCCAGAAGATTGTTGCCACAAGGAAGAAGCAGCAGCTGTCCATAGGACCCTGCAAGTCGCTACCTAATTCTCCCAGCCATTCCTCC GTCTGTTCCGCGCAGGTGTCTGCCGTGCACATCAGCCAGACAAGTAATGGAGGTGGGAGTTTAAGCGACTATTCCTCCTCCGTTCCATCGACTCCCAGCACCAGCCAGAAGGAACTTCGGATCGATGTTCCTCCCACTGCCAACACGCCC ACGCCCGTTCGCAAGCAGTCTAAGCGCCGGTCCAACCTGTTCACCTCTCGGAAAGGGAGCGACCCAGACAAAGAGAAGAAAGGCCTGGAGAGTCGTGCGGACAGCATTGGGAGCGGCCGAGCCATCCCAATTAAACAGGTATGGATGGCA GAACAGAAAATATCATATGATAAGAAGAAACAAGAAGAATTGATGCAGCAATATCTTAAAGAACAAGAATCATATGATAATAGATTGCTTATGGGAGATGAACGTGTAAAGAATGGCCTTAATTTCATGTATGAAGCCCCACCAGGAGCT AAAAAAGAAAACAAAGAGAAAGAAGAAACAGAAGGAGAGACCGAATACAAATTTGAATGGCAGAAAGGAGCCCCACGAGAAAAATATGCCAAAGATGACATGAACATCAGAGATCAGCCCTTTGGTATTCAGGTTCGAAATGTGAGGTGC ATTAAATGTCACAAATGGGGTCATGTCAACACAGATCGAGAATGTCCTTTGTTTGGTCTTTCTGGAATCAATGCAAGTTCGGTTCCCACTGATGGCTCAGATGCTGTGTTACAAATTGAAGGTTTCTGGGCCATCGATGCACCCCTCGGA GCTAATAGCGGAGATGAGAAACAGTGGGTTTGCACTGAAACGAAATGTACTGGGGAGAAACTTGACCGCAAATGATCCATCACAGGAGTATGTTGCAAGTGAGGGTGAAGAAGATCCAGAAGTTGAATTTTTAAAGTCACTAACAACCAA ACAAAAACAGAAACTTCTCAGGAAATTAGATCGACTGGAGAAGAAAAAAAAGAAAAAAGATAGAAAAAAGAAAAAGTTTCAGAAGAGCAGAAGTAAACACAAAAAACATAAGTCCTCTTCTTCCTCATCTTCCTCCTCCTCCTCCTCTTC CTCTACTGAGACTTCAGAAAGCAGTAGTGAGAGTGAGAGTAACAATAAAGAAAAAAAAATACAAAGGAAGAAAAGAAAGAAAAACAAGTGTTCAGGGCATAACAACAGTGATTCTGAAGAGAAGGACAAGTCTAAGAAGAGAAAGCTTCA TGAAGAACTTTCTAGCAGTCACCATAACCGGGAAAAAGCCAAGGAAAAGCCCAGGTTCTTAAAACACGAGAGTTCTAGGGAGGACAGCAAATGGAGCCATTCTGATTCTGACAAAAAGTCCAGAACCCATAAACATAGCCCAGAGAAGAG AGGCTCTGAAAGAAAGGAGGGGAGCAGCAGAAGCCACGGCAGGGAGGAAAGGAGCCGGAGAAGCCGGAGCAGAAGTCCTGGTAGTTACAAGCAAAGGGAGACAAGGAAACGGGCACAGCGAAATCCTGGTGAAGAGCAAAGCAGAAGAAA TGACAGCAGAAGCCATGGCACAGACTTGTATAGAGGAGAAAAAATGTACAGAGAGCACCCAGGAGGTACACATACTAAAGTGACACAAAGAGAATGAAGCAGAAGTAGAGAAGAAAGACTGTATGTGACAATTACCTGGGAATAAAAATA TCTCCACTTTTTTATTGAATACCTTTAGCAAGGGGTAAATTATGTACTGTTGTCTTTCTAATAAAAAAGCTCAATTTTAATTTTTCATCTCTAGACTGTCAATTCAAGTACAAAACTACATGAGTACTATAAGAATGAATTTTGCAAATA TTTGTAAGTAAGCTATTTTGGGGCTGTGGAAATATTTTCTGTTGGTAACTGTTTCTTGTTCCCCATACCAGATAAAAACCGCATATAACTCTGTGACATTTTCTTTGTTCTGAAACATCATTAAAAGAATGACAGTACATTG |
| N-Truncated Transcript (5UTR-3CDS) Sequences |
| C-Truncated Transcript (5CDS-3UTR) Sequences |
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Fusion Protein Sequence for AGAP1_CIR1 |
| In-frame Fusion Protein Sequences. |
| N-Truncated Protein (5UTR-3CDS) Sequences |
| C-Truncated Protein (5CDS-3UTR) Sequences |
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Personalized Fusion Protein Sequence for AGAP1_CIR1 |
| TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| TCGA All Mutated Fusion Protein Sequences |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
| CCLE All Mutated Fusion Protein Sequences |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
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Fusion Gene Exprssed Samples for AGAP1_CIR1 |
| RNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB | COAD | TCGA-AY-5543-01A | AGAP1 | chr2 | 236715975 | - | CIR1 | chr2 | 175252507 | - | |
| ChimerDB | COAD | TCGA-AY-5543-01A | AGAP1 | chr2 | 236715975 | + | CIR1 | chr2 | 175252507 | - | |
| ChimerDB | COAD | TCGA-AY-5543 | AGAP1 | chr2 | 236715975 | + | CIR1 | chr2 | 175252507 | - | |
| WashU | COAD | TCGA-AY-5543-01A | AGAP1 | chr2 | 236715975 | + | CIR1 | chr2 | 175252507 | - |
| DNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | SV type |
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Related Drugs for AGAP1_CIR1 |
| PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug'] * For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub. |
| PMID | Fusion Gene Name | Drug | Study Title |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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