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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:AGAP3_EXOSC9 (FusionGDB2 ID:HG116988TG5393)

Fusion Gene Summary for AGAP3_EXOSC9

Fusion gene summary

Fusion gene information	Fusion gene name: AGAP3_EXOSC9
	Fusion gene ID: hg116988tg5393
		Hgene	Tgene
	Gene symbol	AGAP3	EXOSC9
	Gene ID	116988	5393
	Gene name	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	exosome component 9
	Synonyms	AGAP-3\|CENTG3\|CRAG\|MRIP-1\|cnt-g3	PCH1D\|PM/Scl-75\|PMSCL1\|RRP45\|Rrp45p\|p5\|p6
	Cytomap	7q36.1	4q27
	Type of gene	protein-coding	protein-coding
	Description	arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3CRAM-associated GTPaseCRMP (collapsin response mediator protein) associatedMR1-interacting proteincentaurin-gamma-3	exosome complex component RRP45P75 polymyositis-scleroderma overlap syndrome associated autoantigenPMSCL autoantigen, 75kDautoantigen PM/Scl 1exosome complex exonuclease RRP45polymyositis/scleroderma autoantigen 1, 75kDa
	Modification date	20240403	20240411
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000397238, ENST00000473312, ENST00000479901, ENST00000335367, ENST00000463381, ENST00000476375,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 18 X 10 X 17=3060	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 2 X 46 X 7=644
	# samples	25	515
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(25/306010)=-3.61353165291793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(515/64410)=2.99943983884333 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: AGAP3 [Title/Abstract] AND EXOSC9 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AGAP3(150784159)-EXOSC9(122722981), # samples:1

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Fusion Gene Breakpoints for AGAP3_EXOSC9

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
AGAP3	chr7	150784159	EXOSC9	chr4	150784159
AGAP3	chr7	150784159	EXOSC9	chr4	122722982
AGAP3	chr7	151087072	EXOSC9	chr4	121801827

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for AGAP3_EXOSC9

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	EXOSC9	GO:0006396	RNA processing	17174896\|20531386
Tgene	EXOSC9	GO:0006401	RNA catabolic process	17174896\|20531386

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Fusion Genomic Features for AGAP3_EXOSC9

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
AGAP3	chr7	150784159	+	EXOSC9	chr4	122722981	+	2.62e-08	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for AGAP3_EXOSC9

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000397238	ENST00000379663	AGAP3	chr7	150784159	+	EXOSC9	chr4	122722981	+
5CDS-3UTR	ENST00000397238	ENST00000509980	AGAP3	chr7	150784159	+	EXOSC9	chr4	122722981	+
5CDS-3UTR	ENST00000397238	ENST00000512454	AGAP3	chr7	150784159	+	EXOSC9	chr4	122722981	+
5CDS-3UTR	ENST00000473312	ENST00000379663	AGAP3	chr7	150784159	+	EXOSC9	chr4	122722981	+
5CDS-3UTR	ENST00000473312	ENST00000509980	AGAP3	chr7	150784159	+	EXOSC9	chr4	122722981	+
5CDS-3UTR	ENST00000473312	ENST00000512454	AGAP3	chr7	150784159	+	EXOSC9	chr4	122722981	+
5CDS-3UTR	ENST00000479901	ENST00000379663	AGAP3	chr7	150784159	+	EXOSC9	chr4	122722981	+
5CDS-3UTR	ENST00000479901	ENST00000509980	AGAP3	chr7	150784159	+	EXOSC9	chr4	122722981	+
5CDS-3UTR	ENST00000479901	ENST00000512454	AGAP3	chr7	150784159	+	EXOSC9	chr4	122722981	+
Frame-shift	ENST00000397238	ENST00000243498	AGAP3	chr7	150784159	+	EXOSC9	chr4	122722981	+
Frame-shift	ENST00000473312	ENST00000243498	AGAP3	chr7	150784159	+	EXOSC9	chr4	122722981	+
Frame-shift	ENST00000479901	ENST00000243498	AGAP3	chr7	150784159	+	EXOSC9	chr4	122722981	+

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000397238	ENST00000379663	AGAP3	chr7	150784159	EXOSC9	chr4	122722981	0.00e+00	4.22e-05
ENST00000397238	ENST00000509980	AGAP3	chr7	150784159	EXOSC9	chr4	122722981	0.00e+00	5.52e-04
ENST00000473312	ENST00000379663	AGAP3	chr7	150784159	EXOSC9	chr4	122722981	0.00e+00	4.22e-05
ENST00000473312	ENST00000509980	AGAP3	chr7	150784159	EXOSC9	chr4	122722981	0.00e+00	5.52e-04
ENST00000479901	ENST00000379663	AGAP3	chr7	150784159	EXOSC9	chr4	122722981	0.00e+00	4.22e-05
ENST00000479901	ENST00000509980	AGAP3	chr7	150784159	EXOSC9	chr4	122722981	0.00e+00	5.52e-04

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Fusion Protein Retained/Non-Retained Functional Features for AGAP3_EXOSC9

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for AGAP3_EXOSC9

In-frame Fusion Transcript Sequences.

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

>AGAP3_EXOSC9_ENST00000397238_ENST00000379663_150784159_122722981 length=1689nt 
 Breakpoint=331nt
ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTCGTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCG
CAGCAGCTGGCCGGCGGGCCCCCCCAGCAGTTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATCGAGCGCATCGAGGATTTGGCGCTGCAGAAC
CAGATCCGGGAGCACGTCATCTCCATCGAGGCGGCTGGATGGCAGACAAACCTATGATTATAGGAACATCAGGATCTCATTTGGAACAGATTACGGATGCTGCATTGTGGAACTTGGAAAAACAAGAGTTCTTGGACAGGTTTCCTGTGA
ACTTGTGTCTCCAAAACTCAATCGGGCAACAGAAGGTATTCTTTTTTTTAACCTTGAACTCTCTCAGATGGCCGCTCCAGCTTTCGAACCTGGCAGGCAGTCAGATCTCTTGGTGAAGTTGAATCGACTCATGGAAAGATGTCTAAGAAA
TTCGAAGTGTATAGACACTGAGTCTCTCTGTGTTGTTGCTGGTGAAAAGGTTTGGCAAATACGTGTAGACCTACATTTATTAAATCATGATGGAAATATTATTGATGCTGCCAGCATTGCTGCAATCGTGGCCTTATGTCATTTCCGAAG
ACCTGATGTCTCTGTCCAAGGAGATGAAGTAACACTGTATACACCTGAAGAGCGTGATCCTGTACCATTAAGTATCCACCACATGCCCATTTGTGTCAGTTTTGCCTTTTTCCAGCAAGGAACATATTTATTGGTGGATCCCAATGAACG
AGAAGAACGTGTGATGGATGGCTTGCTGGTGATTGCCATGAACAAACATCGAGAGATTTGTACTATCCAGTCCAGTGGTGGGATAATGCTACTAAAAGATCAAGTTCTGAGATGCAGTAAAATCGCTGGTGTGAAAGTAGCAGAAATTAC
AGAGCTAATATTGAAAGCTTTGGAGAATGACCAAAAAGTAAGGAAAGAAGGTGGAAAGTTTGGTTTTGCAGAGTCTATAGCAAATCAAAGGATCACAGCATTTAAAATGGAAAAGGCCCCTATTGATACCTCGGATGTAGAAGAAAAAGC
AGAAGAAATCATTGCTGAAGCAGAACCTCCTTCAGAAGTTGTTTCTACACCTGTGCTATGGACTCCTGGAACTGCCCAAATTGGAGAGGGAGTAGAAAACTCCTGGGGTGATCTTGAAGACTCTGAGAAGGAAGATGATGAAGGCGGTGG
TGATCAAGCTATCATTCTTGATGGTATAAAAATGGACACTGGAGTAGAAGTCTCTGATATTGGAAGCCAAGAGCTGGGGTTTCACCATGTTGGCCAGACTGGACTCGAGTTCCTGACCTCAGATGCTCCCATAATACTCTCAGATAGTGA
AGAAGAAGAAATGATCATTTTGGAACCAGACAAGAATCCAAAGAAAATAAGAACACAGACCACCAGTGCAAAACAAGAAAAAGCACCAAGTAAAAAGCCAGTGAAAAGAAGAAAAAAGAAGAGAGCTGCCAATTAAAGCTAACAGTTGTA
TATCTGTATATATAACTATTAAAAGGGATATTTATTCCA

>AGAP3_EXOSC9_ENST00000397238_ENST00000509980_150784159_122722981 length=331nt 
 Breakpoint=331nt
ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTCGTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCG
CAGCAGCTGGCCGGCGGGCCCCCCCAGCAGTTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATCGAGCGCATCGAGGATTTGGCGCTGCAGAAC
CAGATCCGGGAGCACGTCATCTCCATCGAGG

>AGAP3_EXOSC9_ENST00000473312_ENST00000379663_150784159_122722981 length=1689nt 
 Breakpoint=331nt
ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTCGTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCG
CAGCAGCTGGCCGGCGGGCCCCCCCAGCAGTTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATCGAGCGCATCGAGGATTTGGCGCTGCAGAAC
CAGATCCGGGAGCACGTCATCTCCATCGAGGCGGCTGGATGGCAGACAAACCTATGATTATAGGAACATCAGGATCTCATTTGGAACAGATTACGGATGCTGCATTGTGGAACTTGGAAAAACAAGAGTTCTTGGACAGGTTTCCTGTGA
ACTTGTGTCTCCAAAACTCAATCGGGCAACAGAAGGTATTCTTTTTTTTAACCTTGAACTCTCTCAGATGGCCGCTCCAGCTTTCGAACCTGGCAGGCAGTCAGATCTCTTGGTGAAGTTGAATCGACTCATGGAAAGATGTCTAAGAAA
TTCGAAGTGTATAGACACTGAGTCTCTCTGTGTTGTTGCTGGTGAAAAGGTTTGGCAAATACGTGTAGACCTACATTTATTAAATCATGATGGAAATATTATTGATGCTGCCAGCATTGCTGCAATCGTGGCCTTATGTCATTTCCGAAG
ACCTGATGTCTCTGTCCAAGGAGATGAAGTAACACTGTATACACCTGAAGAGCGTGATCCTGTACCATTAAGTATCCACCACATGCCCATTTGTGTCAGTTTTGCCTTTTTCCAGCAAGGAACATATTTATTGGTGGATCCCAATGAACG
AGAAGAACGTGTGATGGATGGCTTGCTGGTGATTGCCATGAACAAACATCGAGAGATTTGTACTATCCAGTCCAGTGGTGGGATAATGCTACTAAAAGATCAAGTTCTGAGATGCAGTAAAATCGCTGGTGTGAAAGTAGCAGAAATTAC
AGAGCTAATATTGAAAGCTTTGGAGAATGACCAAAAAGTAAGGAAAGAAGGTGGAAAGTTTGGTTTTGCAGAGTCTATAGCAAATCAAAGGATCACAGCATTTAAAATGGAAAAGGCCCCTATTGATACCTCGGATGTAGAAGAAAAAGC
AGAAGAAATCATTGCTGAAGCAGAACCTCCTTCAGAAGTTGTTTCTACACCTGTGCTATGGACTCCTGGAACTGCCCAAATTGGAGAGGGAGTAGAAAACTCCTGGGGTGATCTTGAAGACTCTGAGAAGGAAGATGATGAAGGCGGTGG
TGATCAAGCTATCATTCTTGATGGTATAAAAATGGACACTGGAGTAGAAGTCTCTGATATTGGAAGCCAAGAGCTGGGGTTTCACCATGTTGGCCAGACTGGACTCGAGTTCCTGACCTCAGATGCTCCCATAATACTCTCAGATAGTGA
AGAAGAAGAAATGATCATTTTGGAACCAGACAAGAATCCAAAGAAAATAAGAACACAGACCACCAGTGCAAAACAAGAAAAAGCACCAAGTAAAAAGCCAGTGAAAAGAAGAAAAAAGAAGAGAGCTGCCAATTAAAGCTAACAGTTGTA
TATCTGTATATATAACTATTAAAAGGGATATTTATTCCA

>AGAP3_EXOSC9_ENST00000473312_ENST00000509980_150784159_122722981 length=331nt 
 Breakpoint=331nt
ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTCGTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCG
CAGCAGCTGGCCGGCGGGCCCCCCCAGCAGTTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATCGAGCGCATCGAGGATTTGGCGCTGCAGAAC
CAGATCCGGGAGCACGTCATCTCCATCGAGG

>AGAP3_EXOSC9_ENST00000479901_ENST00000379663_150784159_122722981 length=1689nt 
 Breakpoint=331nt
ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTCGTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCG
CAGCAGCTGGCCGGCGGGCCCCCCCAGCAGTTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATCGAGCGCATCGAGGATTTGGCGCTGCAGAAC
CAGATCCGGGAGCACGTCATCTCCATCGAGGCGGCTGGATGGCAGACAAACCTATGATTATAGGAACATCAGGATCTCATTTGGAACAGATTACGGATGCTGCATTGTGGAACTTGGAAAAACAAGAGTTCTTGGACAGGTTTCCTGTGA
ACTTGTGTCTCCAAAACTCAATCGGGCAACAGAAGGTATTCTTTTTTTTAACCTTGAACTCTCTCAGATGGCCGCTCCAGCTTTCGAACCTGGCAGGCAGTCAGATCTCTTGGTGAAGTTGAATCGACTCATGGAAAGATGTCTAAGAAA
TTCGAAGTGTATAGACACTGAGTCTCTCTGTGTTGTTGCTGGTGAAAAGGTTTGGCAAATACGTGTAGACCTACATTTATTAAATCATGATGGAAATATTATTGATGCTGCCAGCATTGCTGCAATCGTGGCCTTATGTCATTTCCGAAG
ACCTGATGTCTCTGTCCAAGGAGATGAAGTAACACTGTATACACCTGAAGAGCGTGATCCTGTACCATTAAGTATCCACCACATGCCCATTTGTGTCAGTTTTGCCTTTTTCCAGCAAGGAACATATTTATTGGTGGATCCCAATGAACG
AGAAGAACGTGTGATGGATGGCTTGCTGGTGATTGCCATGAACAAACATCGAGAGATTTGTACTATCCAGTCCAGTGGTGGGATAATGCTACTAAAAGATCAAGTTCTGAGATGCAGTAAAATCGCTGGTGTGAAAGTAGCAGAAATTAC
AGAGCTAATATTGAAAGCTTTGGAGAATGACCAAAAAGTAAGGAAAGAAGGTGGAAAGTTTGGTTTTGCAGAGTCTATAGCAAATCAAAGGATCACAGCATTTAAAATGGAAAAGGCCCCTATTGATACCTCGGATGTAGAAGAAAAAGC
AGAAGAAATCATTGCTGAAGCAGAACCTCCTTCAGAAGTTGTTTCTACACCTGTGCTATGGACTCCTGGAACTGCCCAAATTGGAGAGGGAGTAGAAAACTCCTGGGGTGATCTTGAAGACTCTGAGAAGGAAGATGATGAAGGCGGTGG
TGATCAAGCTATCATTCTTGATGGTATAAAAATGGACACTGGAGTAGAAGTCTCTGATATTGGAAGCCAAGAGCTGGGGTTTCACCATGTTGGCCAGACTGGACTCGAGTTCCTGACCTCAGATGCTCCCATAATACTCTCAGATAGTGA
AGAAGAAGAAATGATCATTTTGGAACCAGACAAGAATCCAAAGAAAATAAGAACACAGACCACCAGTGCAAAACAAGAAAAAGCACCAAGTAAAAAGCCAGTGAAAAGAAGAAAAAAGAAGAGAGCTGCCAATTAAAGCTAACAGTTGTA
TATCTGTATATATAACTATTAAAAGGGATATTTATTCCA

>AGAP3_EXOSC9_ENST00000479901_ENST00000509980_150784159_122722981 length=331nt 
 Breakpoint=331nt
ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTCGTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCG
CAGCAGCTGGCCGGCGGGCCCCCCCAGCAGTTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATCGAGCGCATCGAGGATTTGGCGCTGCAGAAC
CAGATCCGGGAGCACGTCATCTCCATCGAGG

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Fusion Protein Sequence for AGAP3_EXOSC9

In-frame Fusion Protein Sequences.

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for AGAP3_EXOSC9

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for AGAP3_EXOSC9

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		SARC	TCGA-DX-A8BR-01A	AGAP3	chr7	150784159	-	EXOSC9	chr4	0	+
ChimerDB		SARC	TCGA-DX-A8BR-01A	AGAP3	chr7	150784159	+	EXOSC9	chr4	150784159	+
WashU		SARC	TCGA-DX-A8BR-01A	AGAP3	chr7	150784159	+	EXOSC9	chr4	122722982	+
cBioPortal	SARC_TCGA_PAN_CAN_ATLAS_2018	SOFT_TISSUE	TCGA-DX-A8BR-01	AGAP3	chr7	151087072		EXOSC9	chr4	121801827

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for AGAP3_EXOSC9

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status