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Fusion gene:MACROD2_TIPIN (FusionGDB2 ID:HG140733TG54962) |
Fusion Gene Summary for MACROD2_TIPIN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MACROD2_TIPIN | Fusion gene ID: hg140733tg54962 | Hgene | Tgene | Gene symbol | MACROD2 | TIPIN | Gene ID | 140733 | 54962 |
| Gene name | mono-ADP ribosylhydrolase 2 | TIMELESS interacting protein | |
| Synonyms | C20orf133|C2orf133 | - | |
| Cytomap | 20p12.1 | 15q22.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ADP-ribose glycohydrolase MACROD2MACRO domain containing 2MACRO domain-containing protein 2O-acetyl-ADP-ribose deacetylase MACROD2[Protein ADP-ribosylaspartate] hydrolase MACROD2[Protein ADP-ribosylglutamate] hydrolase[Protein ADP-ribosylglutamate] | TIMELESS-interacting proteinCSM3 homolog | |
| Modification date | 20240413 | 20240403 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000217246, ENST00000310348, ENST00000378058, ENST00000402914, ENST00000407045, ENST00000464883, | ||
| Fusion gene scores | * DoF score | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 22 X 116 X 11=28072 | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 4 X 3 X 4=48 |
| # samples | 91 | 5 | |
| ** MAII score | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(91/28072*10)=-4.94712149731611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MACROD2 [Title/Abstract] AND TIPIN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MACROD2(13983050)-TIPIN(66633694), # samples:1 | ||
| Fusion gene breakpoints across MACROD2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across TIPIN (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Breakpoints for MACROD2_TIPIN |
| RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| MACROD2 | chr20 | 13983050 | TIPIN | chr15 | 66633694 |
| DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | SV type |
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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for MACROD2_TIPIN |
| To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence. |
| Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions | Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity | Epigenetic Reprogramming / Histone Modifier Dysregulation | Chromatin Remodeling Dysregulation | Condensate-Driven Transcriptional Rewiring / LLP | Promoter / Enhancer Hijacking | Dominant-Negative Antagonism | Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation | Subcellular Mislocalization / Spatial Dysregulation | Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade |  |  |  |  |  |  |  |  |  |  |
* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MACROD2 | GO:0042278 | purine nucleoside metabolic process | 21257746 |
| Hgene | MACROD2 | GO:0051725 | protein de-ADP-ribosylation | 23474712 |
| Hgene | MACROD2 | GO:0140291 | peptidyl-glutamate ADP-deribosylation | 23474714 |
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Fusion Genomic Features for MACROD2_TIPIN |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| MACROD2 | chr20 | 13983050 | + | TIPIN | chr15 | 66633694 | - | 7.69e-11 | 1.00e+00 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF). |
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Fusion Gene ORF Annotations for MACROD2_TIPIN |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000217246 | ENST00000261881 | MACROD2 | chr20 | 13983050 | + | TIPIN | chr15 | 66633694 | - |
| In-frame | ENST00000217246 | ENST00000367709 | MACROD2 | chr20 | 13983050 | + | TIPIN | chr15 | 66633694 | - |
| In-frame | ENST00000310348 | ENST00000261881 | MACROD2 | chr20 | 13983050 | + | TIPIN | chr15 | 66633694 | - |
| In-frame | ENST00000310348 | ENST00000367709 | MACROD2 | chr20 | 13983050 | + | TIPIN | chr15 | 66633694 | - |
| ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ENST00000217246 | ENST00000261881 | MACROD2 | chr20 | 13983050 | TIPIN | chr15 | 66633694 | 558 | 697 |
| ENST00000217246 | ENST00000367709 | MACROD2 | chr20 | 13983050 | TIPIN | chr15 | 66633694 | 558 | 215 |
| ENST00000310348 | ENST00000261881 | MACROD2 | chr20 | 13983050 | TIPIN | chr15 | 66633694 | 163 | 215 |
| ENST00000310348 | ENST00000367709 | MACROD2 | chr20 | 13983050 | TIPIN | chr15 | 66633694 | 163 | 197 |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| ENST00000217246 | ENST00000261881 | MACROD2 | chr20 | 13983050 | TIPIN | chr15 | 66633694 | 1.44e-02 | 9.86e-01 |
| ENST00000217246 | ENST00000367709 | MACROD2 | chr20 | 13983050 | TIPIN | chr15 | 66633694 | 1.14e-02 | 9.89e-01 |
| ENST00000310348 | ENST00000261881 | MACROD2 | chr20 | 13983050 | TIPIN | chr15 | 66633694 | 2.23e-02 | 9.78e-01 |
| ENST00000310348 | ENST00000367709 | MACROD2 | chr20 | 13983050 | TIPIN | chr15 | 66633694 | 1.62e-02 | 9.84e-01 |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
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Fusion Protein Retained/Non-Retained Functional Features for MACROD2_TIPIN |
| Protein Level Annotation from FGviewer * Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS. |
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| - In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length). |
MACROD2_TIPIN_chr20-13983050_chr15-66633694.png |
| - In-frame and retained protein feature among the 13 regional features (texts). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | TIPIN | chr20:13983050 | chr15:66633694 | ENST00000261881 | Q9BVW5 | 5 | 8 | 240_261 | 158.33333333333334 | 302.0 | Region | Disordered |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MACROD2 | chr20:13983050 | chr15:66633694 | ENST00000217246 | A1Z1Q3 | 2 | 17 | 244_262 | 54.333333333333336 | 426.0 | Compositional bias | Acidic residues |
| Hgene | MACROD2 | chr20:13983050 | chr15:66633694 | ENST00000217246 | A1Z1Q3 | 2 | 17 | 302_343 | 54.333333333333336 | 426.0 | Compositional bias | Basic and acidic residues |
| Hgene | MACROD2 | chr20:13983050 | chr15:66633694 | ENST00000217246 | A1Z1Q3 | 2 | 17 | 344_360 | 54.333333333333336 | 426.0 | Compositional bias | Polar residues |
| Hgene | MACROD2 | chr20:13983050 | chr15:66633694 | ENST00000217246 | A1Z1Q3 | 2 | 17 | 381_391 | 54.333333333333336 | 426.0 | Compositional bias | Basic and acidic residues |
| Hgene | MACROD2 | chr20:13983050 | chr15:66633694 | ENST00000217246 | A1Z1Q3 | 2 | 17 | 415_425 | 54.333333333333336 | 426.0 | Compositional bias | Basic and acidic residues |
| Hgene | MACROD2 | chr20:13983050 | chr15:66633694 | ENST00000217246 | A1Z1Q3 | 2 | 17 | 59_240 | 54.333333333333336 | 426.0 | Domain | Macro |
| Hgene | MACROD2 | chr20:13983050 | chr15:66633694 | ENST00000217246 | A1Z1Q3 | 2 | 17 | 243_425 | 54.333333333333336 | 426.0 | Region | Disordered |
| Tgene | TIPIN | chr20:13983050 | chr15:66633694 | ENST00000261881 | Q9BVW5 | 5 | 8 | 1_61 | 158.33333333333334 | 302.0 | Region | Disordered |
| - Retained PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Fusion Transcript Sequence for MACROD2_TIPIN |
| In-frame Fusion Transcript Sequences. |
>MACROD2_TIPIN_ENST00000217246_ENST00000261881_13983050_66633694 length=1741nt Breakpoint=558nt GCGTGCGCCCTGGGGCCCAAGTTGGGGCGCGCCGTGGCTAGAACACGGAGAGCGGCGGGCAGTGCAGCCAATGGGAGGCGGCGCTGCCTAGCGGCTGGTAGGCGGTGCCTGCGCGGGTGTTAGGTTAGCGCGAGGCGTGACCTAGTTGAC AGGCTCTGAGGTGCTGCTGTGGCGGCGTCCGCGGGGCTGAGGCGGGTGGGAGCCGGAGCCGAGCGCGGGCTGAGGGAGGAGGGCGGCGACTGGAGAGCGGCGAGCGGCGAGCAGCGCAGGACGCAGAGCCTCTTTCACTTTTTCCCTGCT GAGTGCCCCCTCCCACCCCTCCCACTCCACACACACCCTGTTTGCCCGTGAGCCTGGGGAACTTGCAGCTTAAAGCCAGCCACCCCCACGGCAACATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTAT TGAAGATGACCTTAGAAGAGAGACGCAAAGAATACCTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAGGGCCAAAATGATGATGAAGTTGCGGAGAATAATGAACATGATGTCACTTCTACTG AATTAGATCCCTTTCTGACAAACTTATCTGAAAGTGAGATGTTTGCTTCTGAGTTAAGTAGAAGCCTAACAGAAGAGCAACAACAAAGAATTGAGAGAAATAAACAACTGGCCTTGGAAAGAAGGCAGGCAAAGCTGCTGAGTAATAGTC AGACCCTAGGAAATGATATGTTAATGAATACACCCAGGGCACACACGGTTGAAGAGGTTAATACTGATGAGGATCAAAAGGAGGAGTCAAATGGATTAAACGAAGACATTCTGGACAATCCATGTAATGATGCTATTGCCAATACTTTAA ATGAAGAGGAAACACTGCTGGACCAGTCTTTTAAAAATGTGCAACAGCAACTTGATGCTACATCCAGAAATATTACTGAAGCTAGATAAGTTTCCATTAAGAGAAAATGTATCTGTTAAGTCATCGTCCTGCAAGCTTGGCGTTACTATG TATTTTTTCTTCTTGGAGTGAAAATCCTTAGATAGTAAAACTGTTATAGATTATTGTTTAAAATCTGATAATCTGGTATTTATTTATAATTATGCTTGTCACTTTAGTTAAATCTATTTGTTCTCTTTAGTGTTTGTTTTTATATAGGTA TTTCTTCATAAAATGATTAGGAGGTAATAAGCAGTTTCTGCTGCTGGTCTGTCATTGAATGCCTTGTTTTCACTAAGTTGGGAGGTTTTGTTTCTGTTTTTTACTGCTCCTTGCAAAGCAGGGCTAATCCATGGACAGTGTGCCCAGAGT AGTCTAGTTGAAGTTTTTTGTTTTGTTTTGTTTTGTTTTTTTTGACACAGAGTCTCACTCTGTTGGCCAGGCTGGAGTGCAGTGGCACAGTCTTGGCTCACTGCAACCTCTGCCTCCTGGGCTCAAGCAATTCTCCTGCCTTAGCCTCCC GAGTAGCTGGGACTACAGGCGTGTGCCACCACGCTTGGCTAATTTTTGTACTTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTAACCTCAGGTAATCCGCCCCCCTCGGCCTCCCAAAGTGCTGGGATTA CAGGTGTGAGCCACCGCGCCCAGCCTGGGTGAAGTTTTGAGATGTACATATATACTGAATATTAATGTCAATTTTTTAAAAGAAGTAAAAA >MACROD2_TIPIN_ENST00000217246_ENST00000367709_13983050_66633694 length=1563nt Breakpoint=558nt GCGTGCGCCCTGGGGCCCAAGTTGGGGCGCGCCGTGGCTAGAACACGGAGAGCGGCGGGCAGTGCAGCCAATGGGAGGCGGCGCTGCCTAGCGGCTGGTAGGCGGTGCCTGCGCGGGTGTTAGGTTAGCGCGAGGCGTGACCTAGTTGAC AGGCTCTGAGGTGCTGCTGTGGCGGCGTCCGCGGGGCTGAGGCGGGTGGGAGCCGGAGCCGAGCGCGGGCTGAGGGAGGAGGGCGGCGACTGGAGAGCGGCGAGCGGCGAGCAGCGCAGGACGCAGAGCCTCTTTCACTTTTTCCCTGCT GAGTGCCCCCTCCCACCCCTCCCACTCCACACACACCCTGTTTGCCCGTGAGCCTGGGGAACTTGCAGCTTAAAGCCAGCCACCCCCACGGCAACATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTAT TGAAGATGACCTTAGAAGAGAGACGCAAAGAATACCTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAGGGCCAAAATGATGATGAAGTTGCGGAGAATAATGAACATGATGTCACTTCTACTG AATTAGATCCCTTTCTGACAAACTTATCTGAAAGTGAGATGTTTGCTTCTGAGTTAAGTAGAAGCCTAACAGAAGAGCAACAACAAAGAATTGAGAGAAATAAACAACTGGCCTTGGAAAGAAGGCAGGCAAAGCTGCTGAGTAATAGTC AGACCCTAGGAAATGATATGTTAATGAATACACCCAGGGCACACACGGTTGAAGAGGTTAATACTGATGAGGATCAAAAGGAGGAGTCAAATGGATTAAACGAAGACATTCTGGACAATCCATGTAATGATGCTATTGCCAATACTTTAA ATGAAGAGGAAACACTGCTGGACCAGTCTTTTAAAAATGTGCAACAGCAACTTGATGCTACATCCAGAAATATTACTGAAGCTAGATAAGTTTCCATTAAGAGAAAATGTATCTGTTAAGTCATCGTCCTGCAAGCTTGGCGTTACTATG TATTTTTTCTTCTTGGAGTGAAAATCCTTAGATAGTAAAACTGTTATAGATTATTGTTTAAAATCTGATAATCTGGTATTTATTTATAATTATGCTTGTCACTTTAGTTAAATCTATTTGTTCTCTTTAGTGTTTGTTTTTATATAGGTA TTTCTTCATAAAATGATTAGGAGGTAATAAGCAGTTTCTGCTGCTGGTCTGTCATTGAATGCCTTGTTTTCACTAAGTTGGGAGGTTTTGTTTCTGTTTTTTACTGCTCCTTGCAAAGCAGGGCTAATCCATGGACAGTGTGCCCAGAGT AGTCTAGTTGAAGTTTTTTGTTTTGTTTTGTTTTGTTTTTTTTGACACAGAGTCTCACTCTGTTGGCCAGGCTGGAGTGCAGTGGCACAGTCTTGGCTCACTGCAACCTCTGCCTCCTGGGCTCAAGCAATTCTCCTGCCTTAGCCTCCC GAGTAGCTGGGACTACAGGCGTGTGCCACCACGCTTGGCTAATTTTTGTACTTTTAGTAGAGA >MACROD2_TIPIN_ENST00000310348_ENST00000261881_13983050_66633694 length=1346nt Breakpoint=163nt ATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTATTGAAGATGACCTTAGAAGAGAGACGCAAAGAATACCTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAG GGCCAAAATGATGATGAAGTTGCGGAGAATAATGAACATGATGTCACTTCTACTGAATTAGATCCCTTTCTGACAAACTTATCTGAAAGTGAGATGTTTGCTTCTGAGTTAAGTAGAAGCCTAACAGAAGAGCAACAACAAAGAATTGAG AGAAATAAACAACTGGCCTTGGAAAGAAGGCAGGCAAAGCTGCTGAGTAATAGTCAGACCCTAGGAAATGATATGTTAATGAATACACCCAGGGCACACACGGTTGAAGAGGTTAATACTGATGAGGATCAAAAGGAGGAGTCAAATGGA TTAAACGAAGACATTCTGGACAATCCATGTAATGATGCTATTGCCAATACTTTAAATGAAGAGGAAACACTGCTGGACCAGTCTTTTAAAAATGTGCAACAGCAACTTGATGCTACATCCAGAAATATTACTGAAGCTAGATAAGTTTCC ATTAAGAGAAAATGTATCTGTTAAGTCATCGTCCTGCAAGCTTGGCGTTACTATGTATTTTTTCTTCTTGGAGTGAAAATCCTTAGATAGTAAAACTGTTATAGATTATTGTTTAAAATCTGATAATCTGGTATTTATTTATAATTATGC TTGTCACTTTAGTTAAATCTATTTGTTCTCTTTAGTGTTTGTTTTTATATAGGTATTTCTTCATAAAATGATTAGGAGGTAATAAGCAGTTTCTGCTGCTGGTCTGTCATTGAATGCCTTGTTTTCACTAAGTTGGGAGGTTTTGTTTCT GTTTTTTACTGCTCCTTGCAAAGCAGGGCTAATCCATGGACAGTGTGCCCAGAGTAGTCTAGTTGAAGTTTTTTGTTTTGTTTTGTTTTGTTTTTTTTGACACAGAGTCTCACTCTGTTGGCCAGGCTGGAGTGCAGTGGCACAGTCTTG GCTCACTGCAACCTCTGCCTCCTGGGCTCAAGCAATTCTCCTGCCTTAGCCTCCCGAGTAGCTGGGACTACAGGCGTGTGCCACCACGCTTGGCTAATTTTTGTACTTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTGGTCTC AAACTCCTAACCTCAGGTAATCCGCCCCCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCGCCCAGCCTGGGTGAAGTTTTGAGATGTACATATATACTGAATATTAATGTCAATTTTTTAAAAGAAGTAAAAA >MACROD2_TIPIN_ENST00000310348_ENST00000367709_13983050_66633694 length=1168nt Breakpoint=163nt ATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTATTGAAGATGACCTTAGAAGAGAGACGCAAAGAATACCTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAG GGCCAAAATGATGATGAAGTTGCGGAGAATAATGAACATGATGTCACTTCTACTGAATTAGATCCCTTTCTGACAAACTTATCTGAAAGTGAGATGTTTGCTTCTGAGTTAAGTAGAAGCCTAACAGAAGAGCAACAACAAAGAATTGAG AGAAATAAACAACTGGCCTTGGAAAGAAGGCAGGCAAAGCTGCTGAGTAATAGTCAGACCCTAGGAAATGATATGTTAATGAATACACCCAGGGCACACACGGTTGAAGAGGTTAATACTGATGAGGATCAAAAGGAGGAGTCAAATGGA TTAAACGAAGACATTCTGGACAATCCATGTAATGATGCTATTGCCAATACTTTAAATGAAGAGGAAACACTGCTGGACCAGTCTTTTAAAAATGTGCAACAGCAACTTGATGCTACATCCAGAAATATTACTGAAGCTAGATAAGTTTCC ATTAAGAGAAAATGTATCTGTTAAGTCATCGTCCTGCAAGCTTGGCGTTACTATGTATTTTTTCTTCTTGGAGTGAAAATCCTTAGATAGTAAAACTGTTATAGATTATTGTTTAAAATCTGATAATCTGGTATTTATTTATAATTATGC TTGTCACTTTAGTTAAATCTATTTGTTCTCTTTAGTGTTTGTTTTTATATAGGTATTTCTTCATAAAATGATTAGGAGGTAATAAGCAGTTTCTGCTGCTGGTCTGTCATTGAATGCCTTGTTTTCACTAAGTTGGGAGGTTTTGTTTCT GTTTTTTACTGCTCCTTGCAAAGCAGGGCTAATCCATGGACAGTGTGCCCAGAGTAGTCTAGTTGAAGTTTTTTGTTTTGTTTTGTTTTGTTTTTTTTGACACAGAGTCTCACTCTGTTGGCCAGGCTGGAGTGCAGTGGCACAGTCTTG GCTCACTGCAACCTCTGCCTCCTGGGCTCAAGCAATTCTCCTGCCTTAGCCTCCCGAGTAGCTGGGACTACAGGCGTGTGCCACCACGCTTGGCTAATTTTTGTACTTTTAGTAGAGA |
| N-Truncated Transcript (5UTR-3CDS) Sequences |
| C-Truncated Transcript (5CDS-3UTR) Sequences |
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Fusion Protein Sequence for MACROD2_TIPIN |
| In-frame Fusion Protein Sequences. |
>MACROD2_TIPIN_ENST00000217246_ENST00000261881_13983050_66633694 length=697nt MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRALAAASSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIK LDSGVVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYSGSKSPGPSRRSKSPASVKRGGHYSSAYSTAKSPVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKQISAHGRSSSNVNGGPE LDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPE NLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKL KQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKHCQDSGRPGMEPISPVPPSVEEIPVPGEAVPAPTPPESPTPHPPPAAPGGERAGTWRRHRD >MACROD2_TIPIN_ENST00000217246_ENST00000367709_13983050_66633694 length=215nt MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000261881_13983050_66633694 length=215nt MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000367709_13983050_66633694 length=197nt MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRAHTVEEVNTDEDQKEESNG LNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR |
| N-Truncated Protein (5UTR-3CDS) Sequences |
| C-Truncated Protein (5CDS-3UTR) Sequences |
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Personalized Fusion Protein Sequence for MACROD2_TIPIN |
| TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| TCGA All Mutated Fusion Protein Sequences |
>MACROD2_TIPIN_ENST00000217246_ENST00000367709_13983050_66633694_3-gene_p.A216T_215_A130T length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQTKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000217246_ENST00000367709_13983050_66633694_3-gene_p.E257K_215_E171K length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNKDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000217246_ENST00000367709_13983050_66633694_3-gene_p.T238M_215_T152M length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HMVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000217246_ENST00000367709_13983050_66633694_3-gene_p.G254R_215_G168R length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNRLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000217246_ENST00000367709_13983050_66633694_3-gene_p.A269T_215_A183T length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNEDILDNPCNDAITNTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000217246_ENST00000367709_13983050_66633694_3-gene_p.E212K_215_E126K length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALKRRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000217246_ENST00000367709_13983050_66633694_5-gene_p.E55K_215_D73K length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDKEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000217246_ENST00000367709_13983050_66633694_3-gene_p.D261H_215_D175H length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNEDILHNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000217246_ENST00000367709_13983050_66633694_3-gene_p.E257K_215_E171K length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNKDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000217246_ENST00000367709_13983050_66633694_3-gene_p.A162V_215_A76V length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVVENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000217246_ENST00000367709_13983050_66633694_3-gene_p.E241K_215_E155K length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEKVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000217246_ENST00000367709_13983050_66633694_3-gene_p.E198K_215_E112K length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEKQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000217246_ENST00000367709_13983050_66633694_3-gene_p.K217T_215_K131T length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQATLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000217246_ENST00000367709_13983050_66633694_3-gene_p.D168H_215_D82H length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHHVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000261881_13983050_66633694_3-gene_p.A216T_215_A130T length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQTKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000261881_13983050_66633694_3-gene_p.E257K_215_E171K length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNKDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000261881_13983050_66633694_3-gene_p.T238M_215_T152M length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HMVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000261881_13983050_66633694_3-gene_p.G254R_215_G168R length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNRLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000261881_13983050_66633694_3-gene_p.A269T_215_A183T length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNEDILDNPCNDAITNTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000261881_13983050_66633694_3-gene_p.E212K_215_E126K length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALKRRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000261881_13983050_66633694_5-gene_p.E55K_215_D73K length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDKEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000261881_13983050_66633694_3-gene_p.D261H_215_D175H length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNEDILHNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000261881_13983050_66633694_3-gene_p.E257K_215_E171K length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNKDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000261881_13983050_66633694_3-gene_p.A162V_215_A76V length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVVENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000261881_13983050_66633694_3-gene_p.E241K_215_E155K length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEKVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000261881_13983050_66633694_3-gene_p.E198K_215_E112K length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEKQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000261881_13983050_66633694_3-gene_p.K217T_215_K131T length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQATLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000261881_13983050_66633694_3-gene_p.D168H_215_D82H length=215AA MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHHVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRA HTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000367709_13983050_66633694_3-gene_p.A216T_197_A112T length=197AA MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQTKLLSNSQTLGNDMLMNTPRAHTVEEVNTDEDQKEESNG LNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000367709_13983050_66633694_3-gene_p.E257K_197_E153K length=197AA MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRAHTVEEVNTDEDQKEESNG LNKDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000367709_13983050_66633694_3-gene_p.T238M_197_T134M length=197AA MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRAHMVEEVNTDEDQKEESNG LNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000367709_13983050_66633694_3-gene_p.G254R_197_G150R length=197AA MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRAHTVEEVNTDEDQKEESNR LNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000367709_13983050_66633694_3-gene_p.A269T_197_A165T length=197AA MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRAHTVEEVNTDEDQKEESNG LNEDILDNPCNDAITNTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000367709_13983050_66633694_3-gene_p.E212K_197_E108K length=197AA MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALKRRQAKLLSNSQTLGNDMLMNTPRAHTVEEVNTDEDQKEESNG LNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000367709_13983050_66633694_5-gene_p.E55K_197_D55K length=197AA MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDKEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRAHTVEEVNTDEDQKEESNG LNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000367709_13983050_66633694_3-gene_p.D261H_197_D157H length=197AA MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRAHTVEEVNTDEDQKEESNG LNEDILHNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000367709_13983050_66633694_3-gene_p.E257K_197_E153K length=197AA MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRAHTVEEVNTDEDQKEESNG LNKDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000367709_13983050_66633694_3-gene_p.A162V_197_A58V length=197AA MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVVENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRAHTVEEVNTDEDQKEESNG LNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000367709_13983050_66633694_3-gene_p.E241K_197_E137K length=197AA MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRAHTVEKVNTDEDQKEESNG LNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000367709_13983050_66633694_3-gene_p.E198K_197_E94K length=197AA MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEKQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRAHTVEEVNTDEDQKEESNG LNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000367709_13983050_66633694_3-gene_p.K217T_197_K113T length=197AA MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQATLLSNSQTLGNDMLMNTPRAHTVEEVNTDEDQKEESNG LNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR >MACROD2_TIPIN_ENST00000310348_ENST00000367709_13983050_66633694_3-gene_p.D168H_197_D64H length=197AA MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDDEVAENNEHHVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRAHTVEEVNTDEDQKEESNG LNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
| ENST00000217246_ENST00000367709_13983050_66633694 | TCGA-A5-A0GB-01A | 3-gene | p.A216T | 215 | A130T |
| ENST00000217246_ENST00000367709_13983050_66633694 | TCGA-AN-A046-01A | 3-gene | p.E257K | 215 | E171K |
| ENST00000217246_ENST00000367709_13983050_66633694 | TCGA-AX-A2HD-01A | 3-gene | p.T238M | 215 | T152M |
| ENST00000217246_ENST00000367709_13983050_66633694 | TCGA-BF-AAP4-01A | 3-gene | p.G254R | 215 | G168R |
| ENST00000217246_ENST00000367709_13983050_66633694 | TCGA-BR-4368-01A | 3-gene | p.A269T | 215 | A183T |
| ENST00000217246_ENST00000367709_13983050_66633694 | TCGA-BS-A0UF-01A | 3-gene | p.E212K | 215 | E126K |
| ENST00000217246_ENST00000367709_13983050_66633694 | TCGA-CC-A7IJ-01A | 5-gene | p.E55K | 215 | D73K |
| ENST00000217246_ENST00000367709_13983050_66633694 | TCGA-E2-A14Y-01A | 3-gene | p.D261H | 215 | D175H |
| ENST00000217246_ENST00000367709_13983050_66633694 | TCGA-EO-A22R-01A | 3-gene | p.E257K | 215 | E171K |
| ENST00000217246_ENST00000367709_13983050_66633694 | TCGA-ET-A3DU-01A | 3-gene | p.A162V | 215 | A76V |
| ENST00000217246_ENST00000367709_13983050_66633694 | TCGA-GU-AATP-01A | 3-gene | p.E241K | 215 | E155K |
| ENST00000217246_ENST00000367709_13983050_66633694 | TCGA-IB-7651-01A | 3-gene | p.E198K | 215 | E112K |
| ENST00000217246_ENST00000367709_13983050_66633694 | TCGA-WS-AB45-01A | 3-gene | p.K217T | 215 | K131T |
| ENST00000217246_ENST00000367709_13983050_66633694 | TCGA-ZF-A9RD-01A | 3-gene | p.D168H | 215 | D82H |
| ENST00000310348_ENST00000261881_13983050_66633694 | TCGA-A5-A0GB-01A | 3-gene | p.A216T | 215 | A130T |
| ENST00000310348_ENST00000261881_13983050_66633694 | TCGA-AN-A046-01A | 3-gene | p.E257K | 215 | E171K |
| ENST00000310348_ENST00000261881_13983050_66633694 | TCGA-AX-A2HD-01A | 3-gene | p.T238M | 215 | T152M |
| ENST00000310348_ENST00000261881_13983050_66633694 | TCGA-BF-AAP4-01A | 3-gene | p.G254R | 215 | G168R |
| ENST00000310348_ENST00000261881_13983050_66633694 | TCGA-BR-4368-01A | 3-gene | p.A269T | 215 | A183T |
| ENST00000310348_ENST00000261881_13983050_66633694 | TCGA-BS-A0UF-01A | 3-gene | p.E212K | 215 | E126K |
| ENST00000310348_ENST00000261881_13983050_66633694 | TCGA-CC-A7IJ-01A | 5-gene | p.E55K | 215 | D73K |
| ENST00000310348_ENST00000261881_13983050_66633694 | TCGA-E2-A14Y-01A | 3-gene | p.D261H | 215 | D175H |
| ENST00000310348_ENST00000261881_13983050_66633694 | TCGA-EO-A22R-01A | 3-gene | p.E257K | 215 | E171K |
| ENST00000310348_ENST00000261881_13983050_66633694 | TCGA-ET-A3DU-01A | 3-gene | p.A162V | 215 | A76V |
| ENST00000310348_ENST00000261881_13983050_66633694 | TCGA-GU-AATP-01A | 3-gene | p.E241K | 215 | E155K |
| ENST00000310348_ENST00000261881_13983050_66633694 | TCGA-IB-7651-01A | 3-gene | p.E198K | 215 | E112K |
| ENST00000310348_ENST00000261881_13983050_66633694 | TCGA-WS-AB45-01A | 3-gene | p.K217T | 215 | K131T |
| ENST00000310348_ENST00000261881_13983050_66633694 | TCGA-ZF-A9RD-01A | 3-gene | p.D168H | 215 | D82H |
| ENST00000310348_ENST00000367709_13983050_66633694 | TCGA-A5-A0GB-01A | 3-gene | p.A216T | 197 | A112T |
| ENST00000310348_ENST00000367709_13983050_66633694 | TCGA-AN-A046-01A | 3-gene | p.E257K | 197 | E153K |
| ENST00000310348_ENST00000367709_13983050_66633694 | TCGA-AX-A2HD-01A | 3-gene | p.T238M | 197 | T134M |
| ENST00000310348_ENST00000367709_13983050_66633694 | TCGA-BF-AAP4-01A | 3-gene | p.G254R | 197 | G150R |
| ENST00000310348_ENST00000367709_13983050_66633694 | TCGA-BR-4368-01A | 3-gene | p.A269T | 197 | A165T |
| ENST00000310348_ENST00000367709_13983050_66633694 | TCGA-BS-A0UF-01A | 3-gene | p.E212K | 197 | E108K |
| ENST00000310348_ENST00000367709_13983050_66633694 | TCGA-CC-A7IJ-01A | 5-gene | p.E55K | 197 | D55K |
| ENST00000310348_ENST00000367709_13983050_66633694 | TCGA-E2-A14Y-01A | 3-gene | p.D261H | 197 | D157H |
| ENST00000310348_ENST00000367709_13983050_66633694 | TCGA-EO-A22R-01A | 3-gene | p.E257K | 197 | E153K |
| ENST00000310348_ENST00000367709_13983050_66633694 | TCGA-ET-A3DU-01A | 3-gene | p.A162V | 197 | A58V |
| ENST00000310348_ENST00000367709_13983050_66633694 | TCGA-GU-AATP-01A | 3-gene | p.E241K | 197 | E137K |
| ENST00000310348_ENST00000367709_13983050_66633694 | TCGA-IB-7651-01A | 3-gene | p.E198K | 197 | E94K |
| ENST00000310348_ENST00000367709_13983050_66633694 | TCGA-WS-AB45-01A | 3-gene | p.K217T | 197 | K113T |
| ENST00000310348_ENST00000367709_13983050_66633694 | TCGA-ZF-A9RD-01A | 3-gene | p.D168H | 197 | D64H |
| CCLE All Mutated Fusion Protein Sequences |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
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Fusion Gene Exprssed Samples for MACROD2_TIPIN |
| RNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB | BRCA | TCGA-A2-A0SV-01A | MACROD2 | chr20 | 13983050 | + | TIPIN | chr15 | 66633694 | - |
| DNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | SV type |
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Related Drugs for MACROD2_TIPIN |
| PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug'] * For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub. |
| PMID | Fusion Gene Name | Drug | Study Title |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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