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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene Breakpoints

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness

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Fusion Genomic Features

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Fusion Gene ORF Annotations

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Fusion Protein Retained/Non-Retained Functional Features

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Fusion Transcript Sequences

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Fusion Protein Sequences

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Personalized Fusion Protein Sequences

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Fusion Gene Expressed Samples

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Related Drugs

Fusion gene:CLYBL_ARGLU1 (FusionGDB2 ID:HG171425TG55082)

Fusion Gene Summary for CLYBL_ARGLU1

check button Fusion gene summary
Fusion gene informationFusion gene name: CLYBL_ARGLU1
Fusion gene ID: hg171425tg55082
HgeneTgene
Gene symbol

CLYBL

ARGLU1

Gene ID

171425

55082

Gene namecitramalyl-CoA lyasearginine and glutamate rich 1
SynonymsCLB-
Cytomap

13q32.3

13q33.3

Type of geneprotein-codingprotein-coding
Descriptioncitramalyl-CoA lyase, mitochondrial(3S)-malyl-CoA thioesterasebeta-methylmalate synthasecitrate lyase beta likecitrate lyase subunit beta-like protein, mitochondrialmalate synthasearginine and glutamate-rich protein 1
Modification date2024030520240407
UniProtAcc.

Q9NWB6

Ensembl transtripts involved in fusion geneENST00000339105, ENST00000376354, 
ENST00000376355, ENST00000376360, 
ENST00000444838, 
Fusion gene scores* DoF score* DoF score (Degree of Frequency) = # partners X # break points X # disease types
7 X 5 X 6=210
* DoF score (Degree of Frequency) = # partners X # break points X # disease types
3 X 6 X 7=126
# samples 1110
** MAII score** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)
log2(11/210*10)=-0.932885804141463
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)
log2(10/126*10)=-0.333423733725192
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLYBL [Title/Abstract] AND ARGLU1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCLYBL(100259011)-ARGLU1(107212005), # samples:1

check buttonFusion gene breakpoints across CLYBL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ARGLU1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Fusion Gene Breakpoints for CLYBL_ARGLU1


check button RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.
HgeneHchrHbpTgeneTchrTbp
CLYBLchr13100259011ARGLU1chr13107212005


check button DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.
HgeneHchrHbpTgeneTchrTbpSV type


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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for CLYBL_ARGLU1


check button To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.
* We have 10 tumorigenic mechanism categories of fusion genes as shown below.
Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand FusionsAberrant Chimeric Transcription Factor / Fusion Transcription Factor ActivityEpigenetic Reprogramming / Histone Modifier DysregulationChromatin Remodeling DysregulationCondensate-Driven Transcriptional Rewiring / LLPPromoter / Enhancer HijackingDominant-Negative AntagonismCell Cycle / Checkpoint Bypass / RNA Processing DysregulationSubcellular Mislocalization / Spatial DysregulationNuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.
Fusion Gene NameMechanism CategoryMechanism PubMedTumorigenic ScenariosTumorigenic Scenario PubMedTargeting PointsTargeting PubMedMechanism BackgroundMechanism Background PubMed

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.
Fusion Gene NameMechanism CategoryMechanism PubMedTumorigenic ScenariosTumorigenic Scenario PubMedTargeting PointsTargeting PubMedMechanism BackgroundMechanism Background PubMed

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARGLU1

Q9NWB6


check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLYBL

GO:0070207

protein homotrimerization

29056341

HgeneCLYBL

GO:0106064

regulation of cobalamin metabolic process

29056341


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Fusion Genomic Features for CLYBL_ARGLU1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CLYBLchr13100259011+ARGLU1chr13107212005-5.04e-111.00e+00


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).
genomic feature

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Fusion Gene ORF Annotations for CLYBL_ARGLU1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000339105ENST00000375926CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
5CDS-5UTRENST00000376354ENST00000375926CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
5CDS-5UTRENST00000376355ENST00000375926CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
5CDS-5UTRENST00000376360ENST00000375926CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
5CDS-5UTRENST00000444838ENST00000375926CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
In-frameENST00000339105ENST00000400198CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
In-frameENST00000376354ENST00000400198CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
In-frameENST00000376355ENST00000400198CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
In-frameENST00000376360ENST00000400198CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
In-frameENST00000444838ENST00000400198CLYBLchr13

100259011

+ARGLU1chr13

107212005

-

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)
Seq length
(peptide)

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)
Seq length
(peptide)

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)
Seq length
(peptide)

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score
ENST00000339105ENST00000400198CLYBLchr13100259011ARGLU1chr131072120054.82e-039.95e-01
ENST00000376354ENST00000400198CLYBLchr13100259011ARGLU1chr131072120054.28e-039.96e-01
ENST00000376355ENST00000400198CLYBLchr13100259011ARGLU1chr131072120054.91e-039.95e-01
ENST00000376360ENST00000400198CLYBLchr13100259011ARGLU1chr131072120054.21e-039.96e-01
ENST00000444838ENST00000400198CLYBLchr13100259011ARGLU1chr131072120054.21e-039.96e-01

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score

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Fusion Protein Retained/Non-Retained Functional Features for CLYBL_ARGLU1

check buttonProtein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.
fgviewer annotation
- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).
CLYBL_ARGLU1_chr13-100259011_chr13-107212005.png
CLYBL_ARGLU1_chr13-100259011_chr13-107212005.png

- In-frame and retained protein feature among the 13 regional features (texts).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARGLU1chr13:100259011chr13:107212005ENST00000400198Q9NWB604238_253115.66666666666667274.0Compositional biasBasic and acidic residues
TgeneARGLU1chr13:100259011chr13:107212005ENST00000400198Q9NWB604238_273115.66666666666667274.0RegionDisordered

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARGLU1chr13:100259011chr13:107212005ENST00000400198Q9NWB60493_253115.66666666666667274.0Coiled coilOntology_term=ECO:0000255
TgeneARGLU1chr13:100259011chr13:107212005ENST00000400198Q9NWB6041_29115.66666666666667274.0Compositional biasBasic residues
TgeneARGLU1chr13:100259011chr13:107212005ENST00000400198Q9NWB60437_58115.66666666666667274.0Compositional biasBasic residues
TgeneARGLU1chr13:100259011chr13:107212005ENST00000400198Q9NWB60466_84115.66666666666667274.0Compositional biasBasic and acidic residues
TgeneARGLU1chr13:100259011chr13:107212005ENST00000400198Q9NWB60493_113115.66666666666667274.0Compositional biasBasic and acidic residues
TgeneARGLU1chr13:100259011chr13:107212005ENST00000400198Q9NWB6041_113115.66666666666667274.0RegionDisordered
TgeneARGLU1chr13:100259011chr13:107212005ENST00000400198Q9NWB6041_74115.66666666666667274.0RegionNecessary and sufficient for RNA binding
TgeneARGLU1chr13:100259011chr13:107212005ENST00000400198Q9NWB60475_273115.66666666666667274.0RegionNecessary and sufficient for transcriptional regulation


check button - Retained PPIs in in-frame fusion.
PartnerHgeneHbpTgeneTbpENSTUniProtStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerHgeneHbpTgeneTbpENSTUniProtStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Fusion Transcript Sequence for CLYBL_ARGLU1

check button In-frame Fusion Transcript Sequences.
>CLYBL_ARGLU1_ENST00000339105_ENST00000400198_100259011_107212005 length=2860nt
Breakpoint=62nt
ATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAGGCTTCGACAGCAAGAAATAGAAGAAAAACTCATCGAGGAAGAAACAGCACGAAGAGTAGAAGAATTGGTAGCAAAAAGGGTGGAGGAAGAA
CTGGAGAAAAGGAAGGATGAAATTGAACGAGAAGTTCTCCGAAGGGTGGAGGAAGCCAAACGCATCATGGAAAAGCAGTTGCTCGAAGAACTCGAGCGACAGAGACAAGCTGAGCTTGCCGCACAAAAAGCTAGAGAGGAGGAAGAACGT
GCAAAACGTGAGGAGCTAGAGCGAATACTGGAAGAGAATAACCGAAAAATTGCAGAAGCACAAGCCAAACTGGCCGAAGAACAGTTGAGAATTGTTGAAGAACAAAGAAAGATTCATGAGGAAAGGATGAAACTAGAACAAGAACGACAA
CGTCAACAAAAAGAAGAACAAAAAATTATCCTGGGCAAGGGGAAGTCCAGGCCAAAACTGTCCTTCTCATTAAAAACCCAGGATTAAATTGCAAACTCTGAACTTTTTACAAAGAAAAATGGAAAAACTTTGTATGGTAGCTTCATGTTG
AAGTGGTTTTTTGTTTTTGTTTTTGTTTTTTTAATTTGTAAAATCTGGAAAGTTAGCTTGTTCTAATAGGGGCTATGCTCTGCAATTCCCTTTTTTTTTTTTTTTTTCCTTCCACTAAGTCAAATCCTTATCAGATCATTGTTGTATTCT
AAGGAGTGACGTATTTTTCACCTGTTTGGATTCTATATTAGTGGTCTGAGGAAGAGCAGATCACATTGTAAAACTATGGATGGTCTGATAAGGCTTTTACTGACCCCACTGACTTCAGAGTTATACTCTGTTTGCTACATCATAATGCTG
GTTTTGCTGACTTTTTGTTTTTTTATATATTTATAAAAAAAGAAAAAGTTGGTGATTGCATTGGGAAATTCCCAGGGTATTACTGGACCTATGTGGTGTATTGTTAAACCAGTGTCCTTGTGATACTGTTGCTCTTGATGTTCCTGATAC
AGGTAAGGAAACAGTTGGTCAACTCTGATACAAAGTATATATACAGTTCAGTATTGTCTCTGTTCATTTTGTTTTTATTTCATTGACAAAATCAAACCAGCATTCCCCATTGTGTAAATAAATGATTTTGCTGAATAAAGTAAAGTCTTA
AATTCATATGTTGAAGCAATTTTTTTTAATGTTATGTTAAGTCTTAAAGAGGGTGGTTCACTTTTTGATGGTCAACCATTTAGAAGTCTTAGAACTATATTTCCTCTTGTTTATACTTTTAACATAGGGTTTATATGTACATTAAATATA
CTTGTGAATTAGTATTTAATGGCTATTTTTACAAATATCAACTTTATGCTGATAGAGCAAATGGCATCAGTGTTACCTTTAAGAAAGACTAACAACATCCAGAAGATTTAAATTCTCAAACCTGTGCCTCTGTTTTAGGATATAAGTATT
ATCACAAAGTATACTTAATAAAGGCTAGAAAAATGCTTTTAAATTATGGAATCTGAGATCGTTTTCAGAGTGGGCCATCAGAAAGAACTTAGCTTTATACTGTCAAAAAAAGGCTAAGATGGTCGAGTCATTTTCATTGTGTAGTGTACT
TGCACGTTTATTTTTAGGACAAACACATTTGAACTTTATGAATTTTTTTTTTTTTTTTGCATGTGAAATCTTATGAATGGCTTTCATTTTATACACTAGAATCTGCCTCATTTACTCTTAACATATGTTTAAGTATACTGGTATTAAAAC
ATTCAAGAAAAGGATATTGATCTAAAATGCTACCTGAGATGCATAAACATGTCATCAAGTAGAGAAAATATTTTTATTTTTGCCCAATATTTTTTAGACAGTTTGATTATTCTTAAAAATTGAAAACATAAGCTAAAGAGATGACTAAAT
GGTAGATTATTTTGTGTGTGCATGCTAGGAAAAATGCTGTTGCTTTAGTTTTGAGCTCTTCAATGAGTCTAATTGTGGTAAGGAACAATATAAAATCAGTTTAAAGATCTTTAAAGGTAGAATTTTAAATAGGCATGAAATATAGTGAGA
ACTTTTAGTAAACATACTACTTACTCTAAAATCAAACATTTTATTTTCCTAAAGAATATAGGTTGCCAAAAAATATTTTATCTCTAAATATAGGTTAGCTGTAATTATTTCATGAATTTTTTTTTTTTTCAATGTAACTTTTTTTGGTGA
AGATTCATGGTTCCTAAGTTCTGTATTCAAGTTTTTGGAAATGTTTATTTAAAAACTGTTCTATACAAGTGTTCAAAACATTGTATCTAAAGAGAGTAGCCTGGACTTAAAATATTTGAAATCAGCTTATGCGTGCCTTTTAATTTTTTT
TTTAAGTTTCTTACTGCCACATATGGTGTGAAGTGACAGTAAGTTGCTTAATGACATCCTGCAGTATCTGCTTGCTTTTGGAGACTCCAGTGAGATGTTGAAATTGTTCCTGTGCTTGGTAACTACTTTCCTCTGCCAGGCTATGGGAAA
GAGGATGTAATTGTGAATAATATACACCATCCAGTCTTTAATGTGCTGCAACAATGTAGTAATTTGTTTTTTTCATTTGTTCCCACTGCCTTTGTGTACATAGAAAACTTAAAAATTTCCCCCAGTCTATTAGAAGTTAAGATGTTCCCT
AATTTATTAAATATGCCTTTATTCACAATTTGTTTTTTTAGGTTATTCTTAATGCATTATAGAATTAAGTATGACTTTGTTTATTTTTATTACAGTATGTAGTTATTGACATATTGTGGTTTGCAGAATTATCAATTGTATAAACTAAAC
CTTTAAATTA

>CLYBL_ARGLU1_ENST00000376354_ENST00000400198_100259011_107212005 length=2866nt
Breakpoint=68nt
GGGAAGATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAGGCTTCGACAGCAAGAAATAGAAGAAAAACTCATCGAGGAAGAAACAGCACGAAGAGTAGAAGAATTGGTAGCAAAAAGGGTGGAG
GAAGAACTGGAGAAAAGGAAGGATGAAATTGAACGAGAAGTTCTCCGAAGGGTGGAGGAAGCCAAACGCATCATGGAAAAGCAGTTGCTCGAAGAACTCGAGCGACAGAGACAAGCTGAGCTTGCCGCACAAAAAGCTAGAGAGGAGGAA
GAACGTGCAAAACGTGAGGAGCTAGAGCGAATACTGGAAGAGAATAACCGAAAAATTGCAGAAGCACAAGCCAAACTGGCCGAAGAACAGTTGAGAATTGTTGAAGAACAAAGAAAGATTCATGAGGAAAGGATGAAACTAGAACAAGAA
CGACAACGTCAACAAAAAGAAGAACAAAAAATTATCCTGGGCAAGGGGAAGTCCAGGCCAAAACTGTCCTTCTCATTAAAAACCCAGGATTAAATTGCAAACTCTGAACTTTTTACAAAGAAAAATGGAAAAACTTTGTATGGTAGCTTC
ATGTTGAAGTGGTTTTTTGTTTTTGTTTTTGTTTTTTTAATTTGTAAAATCTGGAAAGTTAGCTTGTTCTAATAGGGGCTATGCTCTGCAATTCCCTTTTTTTTTTTTTTTTTCCTTCCACTAAGTCAAATCCTTATCAGATCATTGTTG
TATTCTAAGGAGTGACGTATTTTTCACCTGTTTGGATTCTATATTAGTGGTCTGAGGAAGAGCAGATCACATTGTAAAACTATGGATGGTCTGATAAGGCTTTTACTGACCCCACTGACTTCAGAGTTATACTCTGTTTGCTACATCATA
ATGCTGGTTTTGCTGACTTTTTGTTTTTTTATATATTTATAAAAAAAGAAAAAGTTGGTGATTGCATTGGGAAATTCCCAGGGTATTACTGGACCTATGTGGTGTATTGTTAAACCAGTGTCCTTGTGATACTGTTGCTCTTGATGTTCC
TGATACAGGTAAGGAAACAGTTGGTCAACTCTGATACAAAGTATATATACAGTTCAGTATTGTCTCTGTTCATTTTGTTTTTATTTCATTGACAAAATCAAACCAGCATTCCCCATTGTGTAAATAAATGATTTTGCTGAATAAAGTAAA
GTCTTAAATTCATATGTTGAAGCAATTTTTTTTAATGTTATGTTAAGTCTTAAAGAGGGTGGTTCACTTTTTGATGGTCAACCATTTAGAAGTCTTAGAACTATATTTCCTCTTGTTTATACTTTTAACATAGGGTTTATATGTACATTA
AATATACTTGTGAATTAGTATTTAATGGCTATTTTTACAAATATCAACTTTATGCTGATAGAGCAAATGGCATCAGTGTTACCTTTAAGAAAGACTAACAACATCCAGAAGATTTAAATTCTCAAACCTGTGCCTCTGTTTTAGGATATA
AGTATTATCACAAAGTATACTTAATAAAGGCTAGAAAAATGCTTTTAAATTATGGAATCTGAGATCGTTTTCAGAGTGGGCCATCAGAAAGAACTTAGCTTTATACTGTCAAAAAAAGGCTAAGATGGTCGAGTCATTTTCATTGTGTAG
TGTACTTGCACGTTTATTTTTAGGACAAACACATTTGAACTTTATGAATTTTTTTTTTTTTTTTGCATGTGAAATCTTATGAATGGCTTTCATTTTATACACTAGAATCTGCCTCATTTACTCTTAACATATGTTTAAGTATACTGGTAT
TAAAACATTCAAGAAAAGGATATTGATCTAAAATGCTACCTGAGATGCATAAACATGTCATCAAGTAGAGAAAATATTTTTATTTTTGCCCAATATTTTTTAGACAGTTTGATTATTCTTAAAAATTGAAAACATAAGCTAAAGAGATGA
CTAAATGGTAGATTATTTTGTGTGTGCATGCTAGGAAAAATGCTGTTGCTTTAGTTTTGAGCTCTTCAATGAGTCTAATTGTGGTAAGGAACAATATAAAATCAGTTTAAAGATCTTTAAAGGTAGAATTTTAAATAGGCATGAAATATA
GTGAGAACTTTTAGTAAACATACTACTTACTCTAAAATCAAACATTTTATTTTCCTAAAGAATATAGGTTGCCAAAAAATATTTTATCTCTAAATATAGGTTAGCTGTAATTATTTCATGAATTTTTTTTTTTTTCAATGTAACTTTTTT
TGGTGAAGATTCATGGTTCCTAAGTTCTGTATTCAAGTTTTTGGAAATGTTTATTTAAAAACTGTTCTATACAAGTGTTCAAAACATTGTATCTAAAGAGAGTAGCCTGGACTTAAAATATTTGAAATCAGCTTATGCGTGCCTTTTAAT
TTTTTTTTTAAGTTTCTTACTGCCACATATGGTGTGAAGTGACAGTAAGTTGCTTAATGACATCCTGCAGTATCTGCTTGCTTTTGGAGACTCCAGTGAGATGTTGAAATTGTTCCTGTGCTTGGTAACTACTTTCCTCTGCCAGGCTAT
GGGAAAGAGGATGTAATTGTGAATAATATACACCATCCAGTCTTTAATGTGCTGCAACAATGTAGTAATTTGTTTTTTTCATTTGTTCCCACTGCCTTTGTGTACATAGAAAACTTAAAAATTTCCCCCAGTCTATTAGAAGTTAAGATG
TTCCCTAATTTATTAAATATGCCTTTATTCACAATTTGTTTTTTTAGGTTATTCTTAATGCATTATAGAATTAAGTATGACTTTGTTTATTTTTATTACAGTATGTAGTTATTGACATATTGTGGTTTGCAGAATTATCAATTGTATAAA
CTAAACCTTTAAATTA

>CLYBL_ARGLU1_ENST00000376355_ENST00000400198_100259011_107212005 length=2891nt
Breakpoint=93nt
AGGCAAAGGGCGGGGCGCGCGCGTCGGGAAGATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAGGCTTCGACAGCAAGAAATAGAAGAAAAACTCATCGAGGAAGAAACAGCACGAAGAGTAGA
AGAATTGGTAGCAAAAAGGGTGGAGGAAGAACTGGAGAAAAGGAAGGATGAAATTGAACGAGAAGTTCTCCGAAGGGTGGAGGAAGCCAAACGCATCATGGAAAAGCAGTTGCTCGAAGAACTCGAGCGACAGAGACAAGCTGAGCTTGC
CGCACAAAAAGCTAGAGAGGAGGAAGAACGTGCAAAACGTGAGGAGCTAGAGCGAATACTGGAAGAGAATAACCGAAAAATTGCAGAAGCACAAGCCAAACTGGCCGAAGAACAGTTGAGAATTGTTGAAGAACAAAGAAAGATTCATGA
GGAAAGGATGAAACTAGAACAAGAACGACAACGTCAACAAAAAGAAGAACAAAAAATTATCCTGGGCAAGGGGAAGTCCAGGCCAAAACTGTCCTTCTCATTAAAAACCCAGGATTAAATTGCAAACTCTGAACTTTTTACAAAGAAAAA
TGGAAAAACTTTGTATGGTAGCTTCATGTTGAAGTGGTTTTTTGTTTTTGTTTTTGTTTTTTTAATTTGTAAAATCTGGAAAGTTAGCTTGTTCTAATAGGGGCTATGCTCTGCAATTCCCTTTTTTTTTTTTTTTTTCCTTCCACTAAG
TCAAATCCTTATCAGATCATTGTTGTATTCTAAGGAGTGACGTATTTTTCACCTGTTTGGATTCTATATTAGTGGTCTGAGGAAGAGCAGATCACATTGTAAAACTATGGATGGTCTGATAAGGCTTTTACTGACCCCACTGACTTCAGA
GTTATACTCTGTTTGCTACATCATAATGCTGGTTTTGCTGACTTTTTGTTTTTTTATATATTTATAAAAAAAGAAAAAGTTGGTGATTGCATTGGGAAATTCCCAGGGTATTACTGGACCTATGTGGTGTATTGTTAAACCAGTGTCCTT
GTGATACTGTTGCTCTTGATGTTCCTGATACAGGTAAGGAAACAGTTGGTCAACTCTGATACAAAGTATATATACAGTTCAGTATTGTCTCTGTTCATTTTGTTTTTATTTCATTGACAAAATCAAACCAGCATTCCCCATTGTGTAAAT
AAATGATTTTGCTGAATAAAGTAAAGTCTTAAATTCATATGTTGAAGCAATTTTTTTTAATGTTATGTTAAGTCTTAAAGAGGGTGGTTCACTTTTTGATGGTCAACCATTTAGAAGTCTTAGAACTATATTTCCTCTTGTTTATACTTT
TAACATAGGGTTTATATGTACATTAAATATACTTGTGAATTAGTATTTAATGGCTATTTTTACAAATATCAACTTTATGCTGATAGAGCAAATGGCATCAGTGTTACCTTTAAGAAAGACTAACAACATCCAGAAGATTTAAATTCTCAA
ACCTGTGCCTCTGTTTTAGGATATAAGTATTATCACAAAGTATACTTAATAAAGGCTAGAAAAATGCTTTTAAATTATGGAATCTGAGATCGTTTTCAGAGTGGGCCATCAGAAAGAACTTAGCTTTATACTGTCAAAAAAAGGCTAAGA
TGGTCGAGTCATTTTCATTGTGTAGTGTACTTGCACGTTTATTTTTAGGACAAACACATTTGAACTTTATGAATTTTTTTTTTTTTTTTGCATGTGAAATCTTATGAATGGCTTTCATTTTATACACTAGAATCTGCCTCATTTACTCTT
AACATATGTTTAAGTATACTGGTATTAAAACATTCAAGAAAAGGATATTGATCTAAAATGCTACCTGAGATGCATAAACATGTCATCAAGTAGAGAAAATATTTTTATTTTTGCCCAATATTTTTTAGACAGTTTGATTATTCTTAAAAA
TTGAAAACATAAGCTAAAGAGATGACTAAATGGTAGATTATTTTGTGTGTGCATGCTAGGAAAAATGCTGTTGCTTTAGTTTTGAGCTCTTCAATGAGTCTAATTGTGGTAAGGAACAATATAAAATCAGTTTAAAGATCTTTAAAGGTA
GAATTTTAAATAGGCATGAAATATAGTGAGAACTTTTAGTAAACATACTACTTACTCTAAAATCAAACATTTTATTTTCCTAAAGAATATAGGTTGCCAAAAAATATTTTATCTCTAAATATAGGTTAGCTGTAATTATTTCATGAATTT
TTTTTTTTTTCAATGTAACTTTTTTTGGTGAAGATTCATGGTTCCTAAGTTCTGTATTCAAGTTTTTGGAAATGTTTATTTAAAAACTGTTCTATACAAGTGTTCAAAACATTGTATCTAAAGAGAGTAGCCTGGACTTAAAATATTTGA
AATCAGCTTATGCGTGCCTTTTAATTTTTTTTTTAAGTTTCTTACTGCCACATATGGTGTGAAGTGACAGTAAGTTGCTTAATGACATCCTGCAGTATCTGCTTGCTTTTGGAGACTCCAGTGAGATGTTGAAATTGTTCCTGTGCTTGG
TAACTACTTTCCTCTGCCAGGCTATGGGAAAGAGGATGTAATTGTGAATAATATACACCATCCAGTCTTTAATGTGCTGCAACAATGTAGTAATTTGTTTTTTTCATTTGTTCCCACTGCCTTTGTGTACATAGAAAACTTAAAAATTTC
CCCCAGTCTATTAGAAGTTAAGATGTTCCCTAATTTATTAAATATGCCTTTATTCACAATTTGTTTTTTTAGGTTATTCTTAATGCATTATAGAATTAAGTATGACTTTGTTTATTTTTATTACAGTATGTAGTTATTGACATATTGTGG
TTTGCAGAATTATCAATTGTATAAACTAAACCTTTAAATTA

>CLYBL_ARGLU1_ENST00000376360_ENST00000400198_100259011_107212005 length=2887nt
Breakpoint=89nt
AAAGGGCGGGGCGCGCGCGTCGGGAAGATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAGGCTTCGACAGCAAGAAATAGAAGAAAAACTCATCGAGGAAGAAACAGCACGAAGAGTAGAAGAA
TTGGTAGCAAAAAGGGTGGAGGAAGAACTGGAGAAAAGGAAGGATGAAATTGAACGAGAAGTTCTCCGAAGGGTGGAGGAAGCCAAACGCATCATGGAAAAGCAGTTGCTCGAAGAACTCGAGCGACAGAGACAAGCTGAGCTTGCCGCA
CAAAAAGCTAGAGAGGAGGAAGAACGTGCAAAACGTGAGGAGCTAGAGCGAATACTGGAAGAGAATAACCGAAAAATTGCAGAAGCACAAGCCAAACTGGCCGAAGAACAGTTGAGAATTGTTGAAGAACAAAGAAAGATTCATGAGGAA
AGGATGAAACTAGAACAAGAACGACAACGTCAACAAAAAGAAGAACAAAAAATTATCCTGGGCAAGGGGAAGTCCAGGCCAAAACTGTCCTTCTCATTAAAAACCCAGGATTAAATTGCAAACTCTGAACTTTTTACAAAGAAAAATGGA
AAAACTTTGTATGGTAGCTTCATGTTGAAGTGGTTTTTTGTTTTTGTTTTTGTTTTTTTAATTTGTAAAATCTGGAAAGTTAGCTTGTTCTAATAGGGGCTATGCTCTGCAATTCCCTTTTTTTTTTTTTTTTTCCTTCCACTAAGTCAA
ATCCTTATCAGATCATTGTTGTATTCTAAGGAGTGACGTATTTTTCACCTGTTTGGATTCTATATTAGTGGTCTGAGGAAGAGCAGATCACATTGTAAAACTATGGATGGTCTGATAAGGCTTTTACTGACCCCACTGACTTCAGAGTTA
TACTCTGTTTGCTACATCATAATGCTGGTTTTGCTGACTTTTTGTTTTTTTATATATTTATAAAAAAAGAAAAAGTTGGTGATTGCATTGGGAAATTCCCAGGGTATTACTGGACCTATGTGGTGTATTGTTAAACCAGTGTCCTTGTGA
TACTGTTGCTCTTGATGTTCCTGATACAGGTAAGGAAACAGTTGGTCAACTCTGATACAAAGTATATATACAGTTCAGTATTGTCTCTGTTCATTTTGTTTTTATTTCATTGACAAAATCAAACCAGCATTCCCCATTGTGTAAATAAAT
GATTTTGCTGAATAAAGTAAAGTCTTAAATTCATATGTTGAAGCAATTTTTTTTAATGTTATGTTAAGTCTTAAAGAGGGTGGTTCACTTTTTGATGGTCAACCATTTAGAAGTCTTAGAACTATATTTCCTCTTGTTTATACTTTTAAC
ATAGGGTTTATATGTACATTAAATATACTTGTGAATTAGTATTTAATGGCTATTTTTACAAATATCAACTTTATGCTGATAGAGCAAATGGCATCAGTGTTACCTTTAAGAAAGACTAACAACATCCAGAAGATTTAAATTCTCAAACCT
GTGCCTCTGTTTTAGGATATAAGTATTATCACAAAGTATACTTAATAAAGGCTAGAAAAATGCTTTTAAATTATGGAATCTGAGATCGTTTTCAGAGTGGGCCATCAGAAAGAACTTAGCTTTATACTGTCAAAAAAAGGCTAAGATGGT
CGAGTCATTTTCATTGTGTAGTGTACTTGCACGTTTATTTTTAGGACAAACACATTTGAACTTTATGAATTTTTTTTTTTTTTTTGCATGTGAAATCTTATGAATGGCTTTCATTTTATACACTAGAATCTGCCTCATTTACTCTTAACA
TATGTTTAAGTATACTGGTATTAAAACATTCAAGAAAAGGATATTGATCTAAAATGCTACCTGAGATGCATAAACATGTCATCAAGTAGAGAAAATATTTTTATTTTTGCCCAATATTTTTTAGACAGTTTGATTATTCTTAAAAATTGA
AAACATAAGCTAAAGAGATGACTAAATGGTAGATTATTTTGTGTGTGCATGCTAGGAAAAATGCTGTTGCTTTAGTTTTGAGCTCTTCAATGAGTCTAATTGTGGTAAGGAACAATATAAAATCAGTTTAAAGATCTTTAAAGGTAGAAT
TTTAAATAGGCATGAAATATAGTGAGAACTTTTAGTAAACATACTACTTACTCTAAAATCAAACATTTTATTTTCCTAAAGAATATAGGTTGCCAAAAAATATTTTATCTCTAAATATAGGTTAGCTGTAATTATTTCATGAATTTTTTT
TTTTTTCAATGTAACTTTTTTTGGTGAAGATTCATGGTTCCTAAGTTCTGTATTCAAGTTTTTGGAAATGTTTATTTAAAAACTGTTCTATACAAGTGTTCAAAACATTGTATCTAAAGAGAGTAGCCTGGACTTAAAATATTTGAAATC
AGCTTATGCGTGCCTTTTAATTTTTTTTTTAAGTTTCTTACTGCCACATATGGTGTGAAGTGACAGTAAGTTGCTTAATGACATCCTGCAGTATCTGCTTGCTTTTGGAGACTCCAGTGAGATGTTGAAATTGTTCCTGTGCTTGGTAAC
TACTTTCCTCTGCCAGGCTATGGGAAAGAGGATGTAATTGTGAATAATATACACCATCCAGTCTTTAATGTGCTGCAACAATGTAGTAATTTGTTTTTTTCATTTGTTCCCACTGCCTTTGTGTACATAGAAAACTTAAAAATTTCCCCC
AGTCTATTAGAAGTTAAGATGTTCCCTAATTTATTAAATATGCCTTTATTCACAATTTGTTTTTTTAGGTTATTCTTAATGCATTATAGAATTAAGTATGACTTTGTTTATTTTTATTACAGTATGTAGTTATTGACATATTGTGGTTTG
CAGAATTATCAATTGTATAAACTAAACCTTTAAATTA

>CLYBL_ARGLU1_ENST00000444838_ENST00000400198_100259011_107212005 length=2887nt
Breakpoint=89nt
AAAGGGCGGGGCGCGCGCGTCGGGAAGATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAGGCTTCGACAGCAAGAAATAGAAGAAAAACTCATCGAGGAAGAAACAGCACGAAGAGTAGAAGAA
TTGGTAGCAAAAAGGGTGGAGGAAGAACTGGAGAAAAGGAAGGATGAAATTGAACGAGAAGTTCTCCGAAGGGTGGAGGAAGCCAAACGCATCATGGAAAAGCAGTTGCTCGAAGAACTCGAGCGACAGAGACAAGCTGAGCTTGCCGCA
CAAAAAGCTAGAGAGGAGGAAGAACGTGCAAAACGTGAGGAGCTAGAGCGAATACTGGAAGAGAATAACCGAAAAATTGCAGAAGCACAAGCCAAACTGGCCGAAGAACAGTTGAGAATTGTTGAAGAACAAAGAAAGATTCATGAGGAA
AGGATGAAACTAGAACAAGAACGACAACGTCAACAAAAAGAAGAACAAAAAATTATCCTGGGCAAGGGGAAGTCCAGGCCAAAACTGTCCTTCTCATTAAAAACCCAGGATTAAATTGCAAACTCTGAACTTTTTACAAAGAAAAATGGA
AAAACTTTGTATGGTAGCTTCATGTTGAAGTGGTTTTTTGTTTTTGTTTTTGTTTTTTTAATTTGTAAAATCTGGAAAGTTAGCTTGTTCTAATAGGGGCTATGCTCTGCAATTCCCTTTTTTTTTTTTTTTTTCCTTCCACTAAGTCAA
ATCCTTATCAGATCATTGTTGTATTCTAAGGAGTGACGTATTTTTCACCTGTTTGGATTCTATATTAGTGGTCTGAGGAAGAGCAGATCACATTGTAAAACTATGGATGGTCTGATAAGGCTTTTACTGACCCCACTGACTTCAGAGTTA
TACTCTGTTTGCTACATCATAATGCTGGTTTTGCTGACTTTTTGTTTTTTTATATATTTATAAAAAAAGAAAAAGTTGGTGATTGCATTGGGAAATTCCCAGGGTATTACTGGACCTATGTGGTGTATTGTTAAACCAGTGTCCTTGTGA
TACTGTTGCTCTTGATGTTCCTGATACAGGTAAGGAAACAGTTGGTCAACTCTGATACAAAGTATATATACAGTTCAGTATTGTCTCTGTTCATTTTGTTTTTATTTCATTGACAAAATCAAACCAGCATTCCCCATTGTGTAAATAAAT
GATTTTGCTGAATAAAGTAAAGTCTTAAATTCATATGTTGAAGCAATTTTTTTTAATGTTATGTTAAGTCTTAAAGAGGGTGGTTCACTTTTTGATGGTCAACCATTTAGAAGTCTTAGAACTATATTTCCTCTTGTTTATACTTTTAAC
ATAGGGTTTATATGTACATTAAATATACTTGTGAATTAGTATTTAATGGCTATTTTTACAAATATCAACTTTATGCTGATAGAGCAAATGGCATCAGTGTTACCTTTAAGAAAGACTAACAACATCCAGAAGATTTAAATTCTCAAACCT
GTGCCTCTGTTTTAGGATATAAGTATTATCACAAAGTATACTTAATAAAGGCTAGAAAAATGCTTTTAAATTATGGAATCTGAGATCGTTTTCAGAGTGGGCCATCAGAAAGAACTTAGCTTTATACTGTCAAAAAAAGGCTAAGATGGT
CGAGTCATTTTCATTGTGTAGTGTACTTGCACGTTTATTTTTAGGACAAACACATTTGAACTTTATGAATTTTTTTTTTTTTTTTGCATGTGAAATCTTATGAATGGCTTTCATTTTATACACTAGAATCTGCCTCATTTACTCTTAACA
TATGTTTAAGTATACTGGTATTAAAACATTCAAGAAAAGGATATTGATCTAAAATGCTACCTGAGATGCATAAACATGTCATCAAGTAGAGAAAATATTTTTATTTTTGCCCAATATTTTTTAGACAGTTTGATTATTCTTAAAAATTGA
AAACATAAGCTAAAGAGATGACTAAATGGTAGATTATTTTGTGTGTGCATGCTAGGAAAAATGCTGTTGCTTTAGTTTTGAGCTCTTCAATGAGTCTAATTGTGGTAAGGAACAATATAAAATCAGTTTAAAGATCTTTAAAGGTAGAAT
TTTAAATAGGCATGAAATATAGTGAGAACTTTTAGTAAACATACTACTTACTCTAAAATCAAACATTTTATTTTCCTAAAGAATATAGGTTGCCAAAAAATATTTTATCTCTAAATATAGGTTAGCTGTAATTATTTCATGAATTTTTTT
TTTTTTCAATGTAACTTTTTTTGGTGAAGATTCATGGTTCCTAAGTTCTGTATTCAAGTTTTTGGAAATGTTTATTTAAAAACTGTTCTATACAAGTGTTCAAAACATTGTATCTAAAGAGAGTAGCCTGGACTTAAAATATTTGAAATC
AGCTTATGCGTGCCTTTTAATTTTTTTTTTAAGTTTCTTACTGCCACATATGGTGTGAAGTGACAGTAAGTTGCTTAATGACATCCTGCAGTATCTGCTTGCTTTTGGAGACTCCAGTGAGATGTTGAAATTGTTCCTGTGCTTGGTAAC
TACTTTCCTCTGCCAGGCTATGGGAAAGAGGATGTAATTGTGAATAATATACACCATCCAGTCTTTAATGTGCTGCAACAATGTAGTAATTTGTTTTTTTCATTTGTTCCCACTGCCTTTGTGTACATAGAAAACTTAAAAATTTCCCCC
AGTCTATTAGAAGTTAAGATGTTCCCTAATTTATTAAATATGCCTTTATTCACAATTTGTTTTTTTAGGTTATTCTTAATGCATTATAGAATTAAGTATGACTTTGTTTATTTTTATTACAGTATGTAGTTATTGACATATTGTGGTTTG
CAGAATTATCAATTGTATAAACTAAACCTTTAAATTA


check button N-Truncated Transcript (5UTR-3CDS) Sequences

check button C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for CLYBL_ARGLU1

check button In-frame Fusion Protein Sequences.

check button N-Truncated Protein (5UTR-3CDS) Sequences

check button C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for CLYBL_ARGLU1


check button TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences
NumGene GroupDomain LociFusion Protein IDFusion Gene NamePartnerMutated Residue in WT ProteinSeq. LengthMutated Residue in Fusion Protein

check button CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

NumGene GroupDomain LociFusion Protein IDFusion Gene NamePartnerMutated Residue in WT ProteinSeq. LengthMutated Residue in Fusion Protein

check button TCGA All Mutated Fusion Protein Sequences


Fusion Protein IDSample IDMutated PartnerAAchange in WTSeq. LengthAAchange in Fusion

check button CCLE All Mutated Fusion Protein Sequences


Fusion Protein IDSample IDMutated PartnerAAchange in WTSeq. LengthAAchange in Fusion

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Fusion Gene Exprssed Samples for CLYBL_ARGLU1


check buttonRNA-seq based fusion gene expressed samples.
SourceStudyDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4FusionScanGSE122401CLYBL

chr13

100259011+ARGLU1

chr13

107212005

-

check buttonDNA-seq based fusion gene expressed samples.
SourceStudyDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrandSV type


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Related Drugs for CLYBL_ARGLU1


check button PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.
PMIDFusion Gene NameDrugStudy Title

check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status