|
||||||
|
Fusion gene:DPP4_PDK1 (FusionGDB2 ID:HG1803TG5163) |
Fusion Gene Summary for DPP4_PDK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DPP4_PDK1 | Fusion gene ID: hg1803tg5163 | Hgene | Tgene | Gene symbol | DPP4 | PDK1 | Gene ID | 1803 | 5163 |
| Gene name | dipeptidyl peptidase 4 | pyruvate dehydrogenase kinase 1 | |
| Synonyms | ADABP|ADCP2|CD26|DPPIV|TP103 | - | |
| Cytomap | 2q24.2 | 2q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dipeptidyl peptidase 4ADCP-2DPP IVGly-Pro naphthylamidasePost-proline dipeptidyl aminopeptidase IVT-cell activation antigen CD26Xaa-Pro-dipeptidylaminopeptidaseadenosine deaminase complexing protein 2dipeptidyl peptidase IVdipeptidylpeptidase 4d | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrialpyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrialPDH kinase 1mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1pyruvate dehydroge | |
| Modification date | 20240323 | 20240411 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000360534, ENST00000491591, | ||
| Fusion gene scores | * DoF score | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 3 X 6 X 5=90 | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 3 X 11 X 8=264 |
| # samples | 6 | 17 | |
| ** MAII score | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(17/264*10)=-0.635003183220752 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DPP4 [Title/Abstract] AND PDK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DPP4(162902041)-PDK1(173451005), # samples:1 | ||
| Fusion gene breakpoints across DPP4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across PDK1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Fusion Gene Breakpoints for DPP4_PDK1 |
| RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| DPP4 | chr2 | 162902041 | PDK1 | chr2 | 162902041 |
| DPP4 | chr2 | 162902042 | PDK1 | chr2 | 173451006 |
| DPP4 | chr2 | 162045532 | PDK1 | chr2 | 172586278 |
| DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | SV type |
Top |
Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for DPP4_PDK1 |
| To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence. |
| Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions | Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity | Epigenetic Reprogramming / Histone Modifier Dysregulation | Chromatin Remodeling Dysregulation | Condensate-Driven Transcriptional Rewiring / LLP | Promoter / Enhancer Hijacking | Dominant-Negative Antagonism | Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation | Subcellular Mislocalization / Spatial Dysregulation | Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade |  |  |  |  |  |  |  |  |  |  |
* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DPP4 | GO:0001666 | response to hypoxia | 16670267 |
| Hgene | DPP4 | GO:0006508 | proteolysis | 27198182 |
| Hgene | DPP4 | GO:0008284 | positive regulation of cell population proliferation | 17549790 |
| Hgene | DPP4 | GO:0010716 | negative regulation of extracellular matrix disassembly | 16651416 |
| Hgene | DPP4 | GO:0031295 | T cell costimulation | 10900005|17287217 |
| Hgene | DPP4 | GO:0033632 | regulation of cell-cell adhesion mediated by integrin | 11772392 |
| Hgene | DPP4 | GO:0042110 | T cell activation | 7594462 |
| Hgene | DPP4 | GO:0043542 | endothelial cell migration | 16651416 |
Top |
Fusion Genomic Features for DPP4_PDK1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| DPP4 | chr2 | 162902041 | - | PDK1 | chr2 | 173451005 | + | 2.22e-03 | 9.98e-01 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF). |
 |
Top |
Fusion Gene ORF Annotations for DPP4_PDK1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000360534 | ENST00000282077 | DPP4 | chr2 | 162902041 | - | PDK1 | chr2 | 173451005 | + |
| In-frame | ENST00000360534 | ENST00000392571 | DPP4 | chr2 | 162902041 | - | PDK1 | chr2 | 173451005 | + |
| In-frame | ENST00000360534 | ENST00000410055 | DPP4 | chr2 | 162902041 | - | PDK1 | chr2 | 173451005 | + |
| In-frame | ENST00000360534 | ENST00000543905 | DPP4 | chr2 | 162902041 | - | PDK1 | chr2 | 173451005 | + |
| In-frame | ENST00000360534 | ENST00000544863 | DPP4 | chr2 | 162902041 | - | PDK1 | chr2 | 173451005 | + |
| ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| ENST00000360534 | ENST00000282077 | DPP4 | chr2 | 162902041 | PDK1 | chr2 | 173451005 | 1.00e-02 | 9.90e-01 |
| ENST00000360534 | ENST00000392571 | DPP4 | chr2 | 162902041 | PDK1 | chr2 | 173451005 | 6.79e-03 | 9.93e-01 |
| ENST00000360534 | ENST00000410055 | DPP4 | chr2 | 162902041 | PDK1 | chr2 | 173451005 | 6.93e-03 | 9.93e-01 |
| ENST00000360534 | ENST00000543905 | DPP4 | chr2 | 162902041 | PDK1 | chr2 | 173451005 | 7.10e-03 | 9.93e-01 |
| ENST00000360534 | ENST00000544863 | DPP4 | chr2 | 162902041 | PDK1 | chr2 | 173451005 | 7.24e-03 | 9.93e-01 |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
Top |
Fusion Protein Retained/Non-Retained Functional Features for DPP4_PDK1 |
| Protein Level Annotation from FGviewer * Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS. |
 |
| - In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length). |
DPP4_PDK1_chr2-162902041_chr2-173451005.png |
| - In-frame and retained protein feature among the 13 regional features (texts). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DPP4 | chr2:162902041 | chr2:173451005 | ENST00000360534 | P27487 | 5 | 26 | 1_6 | 122.0 | 767.0 | Topological domain | Cytoplasmic |
| Hgene | DPP4 | chr2:162902041 | chr2:173451005 | ENST00000360534 | P27487 | 5 | 26 | 7_28 | 122.0 | 767.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DPP4 | chr2:162902041 | chr2:173451005 | ENST00000360534 | P27487 | 5 | 26 | 29_766 | 122.0 | 767.0 | Topological domain | Extracellular |
| Tgene | PDK1 | chr2:162902041 | chr2:173451005 | ENST00000282077 | Q15118 | 7 | 11 | 163_393 | 315.0 | 437.0 | Domain | Histidine kinase |
| - Retained PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Fusion Transcript Sequence for DPP4_PDK1 |
| In-frame Fusion Transcript Sequences. |
>DPP4_PDK1_ENST00000360534_ENST00000282077_162902041_173451005 length=13993nt Breakpoint=927nt CTTTCACTGGCAAGAGACGGAGTCCTGGGTTTCAGTTCCAGTTGCCTGCGGTGGGCTGTGTGAGTTTGCCAAAGTCCCCTGCCCTCTCTGGGTCTCGGTTCCCTCGCCTGTCCACGTGAGGTTGGAGGAGCTGAACGCCGACGTCATTTT TAGCTAAGAGGGAGCAGGGTCCCCGAGTCGCCGGCCCAGGGTCTGCGCATCCGAGGCCGCGCGCCCTTTCCCCTCCCCCACGGCTCCTCCGGGCCCCGCACTCTGCGCCCCGGCTGCCGCCCAGCGCCCTACACCGCCCTCAGGGGGCCC TCGCGGGCTCCCCCCGGCCGGGATGCCAGTGCCCCGCGCCACGCGCGCCTGCTCCCGCGCCGCCTGCCCTGCAGCCTGCCCGCGGCGCCTTTATACCCAGCGGGCTCGGCGCTCACTAATGTTTAACTCGGGGCCGAAACTTGCCAGCGG CGAGTGACTCCACCGCCCGGAGCAGCGGTGCAGGACGCGCGTCTCCGCCGCCCGCGGTGACTTCTGCCTGCGCTCCTTCTCTGAACGCTCACTTCCGAGGAGACGCCGACGATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGT GCTGCTGCGCTTGTCACCATCATCACCGTGCCCGTGGTTCTGCTGAACAAAGGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTATAGACTGAAGTTATACTCCTTAAGATGGATT TCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATATGGAAACAGCTCAGTTTTCTTGGAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTT ATTCTCTTAGAATACAACTACGTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTATTCAACTGCACCAAGACCTCGTGTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGT TATGGATTGCCCATATCACGTCTTTACGCACAATACTTCCAAGGAGACCTGAAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCAATAGAAAGACTCCCAGTGTATAACAAAGCT GCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAACCCAAAGACATGACGACGTTCCGCAGTGCCTAGACACACTTGGGACATCGGAAAATCCAAATGTGGCTTTTGTATTAAATTTGGAAGGTA TGGTGTTCAGAACTATATTATACCAAGTACTTTATTTATCGTTTTCACAAAACTATTTGAGTAGAATAAATGGAAACTGAATTCCATTTGTGCCCGTTAAACCTCCTAAAGGATGAAATTGCACCTATTTTACACTTATATTTTCACAGT TAATTGAACATATTTTTAAACAACTGTAGTTTTGGGCAACTTTTCACTTTGTGGTAGACTTCAGAAGTGTGGAAATCTTCGGGTTTCTATAGGAAACTAGTTTTTTTTTTTTAAGAAATACTTTCATTTATGTTTGCTAGAAACATTTTC TAAATGATAGTGATTAGCTGGTTAGCCATCTTCCTGTTATTTGGAGGAGTTCTGCCATCTTTTATTCGGTAGTGACAGCTGTAATATGGTCTTCATGTTTATCAGTGACTTGACTACAAGTAAAGCAGAAAACAGTTGGCCTGTAATCAC AGAACCAGCCACCCTTCGGCGTCTACATGCATTGTCTTAGCTCTGAGGTTAATTTACCATTTTTAAATTTTATTGTAAAGAAGTGTAATGACTAGCTCTCTGTGGATCTATGCCAAAATCATGGGCCATCTTTTCTAAGTGTACTTCTGA TTAATGCAAGGGGAAATTTTTATACTGAAAACAAACAAACAAACTAGCAGCTACTAAAATAGAGAAGAAATTGAGGGCAAAGTAATATGTCTCCAAAACTGAACTGATTGCTTGTTGAGATTACCTAGAAAGCTTTTGGAAAAAAATAGA GCTTTTCTGCATCCTACTCCAGATACACTGAATCGGAATCCCTAGGGCTAGAGCCTAGAAATCTCACTTTTTAAAATGCTTCCAAGGTAAGTCTGATGCCTACCCTAGGTTGGGAACCACTCTTTCAAAGTAAACAGTGATGACACAGCA TTTGCTAAAGTAACATCTGTAGGTTTTGGTTTCCACCTATTTAAAGTCAGATTTATAGACTCGAGGAGACAGAAACTGAATCCCACACCTGGTGCAATTAGAAGCATAATTAGAAGCAGAAGAACAAAATGCCACGTAACCAAAGCATCA GAGCCATCATTGCACGTGTCTTTTTTTCTTTTTTCTTTTTTTTTTTTCAAGACAGGGTCTCGCTCTTTTGCCCAGGATGGAGTACAGTGGCATGGTCAAGGCTCACTGCAGCTTCAATCTTCTGGGCTCAAGTAATCCTTCCACCTCAGC CTCCCATATAGCTGGAACTACAGTTGTGCACTACCACACCCAGCTAATTTTTTGATTTCTTGTGGAGATGAGGTCTCAGTATGTTCCCAGGCTAGTGTTGAACTCCTGAGCTCAAGAAATCCTCCTGCCTGAGTCTCTGAAAGTGCTGGG ATTACAGGCGTGAGCCACCACACATGGCCTATTGCACAAGTCTTGACAAACAACATATATTTTCTAAAACTATCCAGATTTCATTATCAGGGAAAAGTTTGCTTAGGTTTATTACAGCAGTCCTTGGCATTTGTATGGTAATTTGTACTT TACAAATACTTTGATATATTATAACTCTATTGGTCTTTGAAACAAAGCGATACAGTGTAGGTGGTATCATTCTCTTTCTCACTCAGTGTGGCCCAGAGTTGCTCAGAATTGGAGCAGAGCCTGAGACGTATCTGCAGATCCTGTCATCAG CTGGCAAGTCCAGGAGACTGTGTCATTTAGAGACTGTGTTGTTAGTTATCCCTCAACATCTTCTAAGGTGGCAGGAAATAATATTGGAAATAACATTTTAAAGTAAAAATTTTAAAGTTTAAAGAAGAGTTTTGCCACTTAAACAGGGGA GCTTTGTCTGGAAAATACACTGAGTTGAAACACTTCATCCTTGGAAGGATTATATAAGATGAACAGTTGTGATAAATGTGTAGATTAGAGGGATGTGAATGGGCAGTTAGTCCAGTGCCCTCATTTAAGAGGCCAAGATCCTGATTCAGA GGAGGCATCCTTTGCCCAGAGCTGCTTAGCTAATCTGACCAAATGTTGGGAAAAATGTCTCACCTAACCCACTATTCCTTAATTATGGATTTTGTGAAAAACAATAGAACATGTTAATGAGTAATTTATATTAGTTCGATGTATTACAAT TTTTTAGCTTTAAATTACAGTTTTCTTATAATGTTGAAATGTTTTAGAATCCTTTGAATCTAAGTATTTGTTTCCTAAATGAAACATTTGTACAACATTTGATGTTTTTACTTATGAAATATTCTCCTCCCCCAAGAAAATTTAAACTTT TTCTCTCTATTTAAAAGCTAAGAAATGTTTTAAAGGAAAAATGAAATTATCTTCCTTTAGCTTATTTTTAAGGTAAAACAGCTTTTTACTCTGTTATTGTGGTAATGGACAGAATATTACATACAAAAATATTCTGGGAGAGCTTTTTCC TAGTTGGTTTTAAATCATTGTGCCACCTGAAAGGTTTTTAGATTTTATAGGAGCTAATTTGTCCACCAGCATTAATGTAACACAGTGTAGTTATGAAAATATATTGAAGGACAGGAAGTGGACACGAAGTGATTTTTGTAACCTGAGCAG TTAATGAATGTGCCAACATTTTCTAGGAAGGGACAGCAAGAATATTCTGCTCTGTAGTTAAAATACTGGCTGGCTTTTGATGTCTTCATGCTTAATTGTGATCACTTTCTTGCACTGTGATGTTTTTACGTGAATATGTTGAAGTAGAAG TCTACCATATTATTTTATAAAATGTTTTCTGTATGGCAATAAACTGAAAACATGGATCAACCCTTCTTTTGAAAATAAACTGAGTCAATTTAGCCTTTTAAAAATATAGTCATCTCTTTTAAATAGAATCCTCTTCCACCATCAAGGCTC AACATTTTGTAAGCATCCAAAAAATTGGTAATTAGGGGGCTTGCACTAAATTTCACTATCTTCAGTAGAGAGGAACTGTTTGGAACTTAGATTTCCAATGTGTATATTCTAATGGAGAAAGCAAGAGGTAGAGTTTGTATGTTTGACTTA CCTTAGATTTTTATTTTCCATACATACTGCAAATGATTGACTTGTTGCATAAATGAAGATCTTCTGTTGTGTGCTTTTCAAACACTGTAAATAAATTTGAAATTTGAATAACTTTCCACAGTATAACTGTAAAAAAAAAAAAAAAAAGTC TTAATTTAACCAGCATTACCCTCTGCTTGTACCAATTGAATGGCAGAACTACTATAGTCAAAAATAAATTCCTATCCTATTTTTAATTGATGGGATATAGGCAGCACAATTTCCCTTCATTGTTGAAGCCAACAAGTTCCGTAACAGAAC TCCAGAGGTAAATAGCTGGGAAAACTGTTAGTTTTAAGGTCCCACTGTTGCTCTGTGAATGACTAATCAGAGGAAGCCAAAAATCAGCCAACTAATTTCAGTTTATGTCTTTAATTGTGATGTAAGTGTGAAGTTTCTACATATGGGTAA TCAGGGTTGAGTTAGGTAGTTTGCAAACATGACTTTTGCTGGAGGAACTTTTAATCATGTCTTATTAATTTCTGGTCCCAATAATTAATTTTCTTACAGTCAAACCCAATGCACTTGAAAAATAATATAATTAATACTGTGTGAAGAATT TTTTGCATGTTAAAAAAAGCAAACCACTAGTTTGCTTAGTTCTGGCATTCATAAACTACTGTACCTTCTGTTCTATTGACATGTTTGGAAAAAAGAATTGAACATATGTACCACCCCCCTCTTTCTAGAGTCTCCACAGTTCTTTAGCAA TTGCTAACCATAGGTTTTTAATAGCAAAAGACAAGATTGTCAGTTTTTGGTGCAAAACTCTACTCTTTTTGGTTGACTTGGAAAAGCTGTTGTTTATATTGGGAATTGTGACAGCTGTCTTTTACTTTGTTAAATTAGCAATTATTTAGC AAAAATACAGAGTTTCACCCCAGTAAAATAAACTTCCACGTGAGAGTTGTGTTCATTCAAGGGTTATTTTTTGAGAGTGGAAGTACATTTCCTGCATTTGTCACAGATAATATCAGAAATTTTGTTGTTTTGATTAAAATGTTGCCATCT ACTTATAAGTTAAAAATGCTGAGAAGGTTTTTTTTGGAAACAGTTTATGAGGCCAGGACATTTTTAAGTTTGACTCAAATATAAAAAGCCACAGTATTCTTGCCATGGTTTTGTACTTAGATGTCTCTCATTATGGAATTCAGAATGTGA CAGTTATAGTACTACATGAAAATACTTAATATAGAGTTCTACAGTTACAGTATTGCATGAAAATACAGTATGGTATGAAATTATTTGTCCAAAACTGTACTCCAGAAATGGAGCCCATATGATTATATAACTATAAAATAGGATGGGACA GAGAAAAATATGTCTGTATTACAGCATAAACATATCTGGTTTAATATGAACTATTTCTTTTCATCTCTTTACTCTCAGTATCTCCATAATGGCCAGTATGTAGTAGGCACCTGTAATTGTGAAGCAGCCTCATTGTCTGGGGTAAATACC AAGGTTCTTGGTCTCATGGCCAAGGAGATCGAGGTCGCAGACACACACAGTTTGGAGCAGGAGTTTAATAGGCAAAAGGAAACAGCTCTGTTACAGAGAGGGGTTCCGAGCAGGTTGCCAAGTTGTAGTAAAAATGTCAGGGTTTTTATA AATGGGCTAGTGAGGAGGGGGCTCATGAGGAGGGGATATCTTATCCTCCTAGGGTCCGAGGACGCTTTAGTTGGGACCAGGTGTGCTATCTGTACAGAGCATAGCTTTTTATCAGCTCTTATCCCATTCCTTGACCACATAGGCTCTTAG ACTCTTATTCTATGTTGTCTTCGTCCAGCTTATCTGGAAGGGAGAGTTTCTCTGTCTGTTCCCATACATCTTGCAGCTGCAGGCATCCCCCCGGTCTGCTTTTAGCTTCCTTATCTTAGTGCCCCTAAAGGGAAAGGAATGTGCTTATTA AGGGCCACTGTTTTACTGGGGTTAACTGCATGAGGTCAAAAAGAGCTATATTTGAGCTGCTGTTTGTTAAAAGAAAAGTTTTCTGCCGGGGACTCGCTTTACCCTGTCTACCTAAATTCTTTCTGCCTTCTATAACAATTGTATGCTCAG TAAATACATAAGGAATAATGAACTTAATAACATTTTTTTCCATTCTCAAAATGATACTTAAATGACTCAGTACAACAAAGAAACTGAGTAGTAACCAGTGCAAAACTAGCAAAAGGATGAAATACACAAGAAAATGAGAGAATTTAAGAG GAGTAGCAAAACAGCACTGCTAAAGTTACGGGTTTATTTTAAAGTTTAAAATAGAAGTAAACAAGCAAACATACTGATAATGGTTAGGCTTTCTGTCCCCACCGCACAAATCTCATCTTGAATTATAATCTCAACATGTTAAGGGAGAGA CCAGATGAAAGTAATTGGATCATGGGGTTGGTTTCTCCCATGCTGTTCTCGTGATAGTTCCCATGAGATCTGATGGTTTTATAAGTATTTGGTAGTTCCTCCTGCATTCATTCTTCCTGCTGCCCTGTGAAGAGGTGCCTTCCACCATGA TTGTGAGTTTCTGGAGGCTTCTGCAGCCTTGCGGAACTGTGAGTCAATCCTTTTTATTATAAATTACCCCGTCTCAGGCAGTTCTTTATAGCAGTGTGGGGATGGACTAATACTCGCTGGGTTAGCTGGGGTAGGTAAAGCCACAGCTGT GGCAGCAACCAGCTAGTGGGTGTCCCTTGATGGAGGCTTTGCAGGCTGCAGCAGAAGGGACCCTTCAGATAAACCTCCAGTCAGGAAAGGAAAAGGCCCAAATAAACAGTATTTAGATTTTTTTTTAAAGGACATAACTACCAATAGAGA TTTAAAATAATCATAAGAATACCATTAACTTTATGATAAAAATTTTGTAAGTGGAGAAGAAATGGATATATTTCTAGGAAAACAGTAGAAGATCCATCTAAGATTTTGACAATTTAAATCAACCACTAAGGAAGTGGAATCAGTAATCAC AAGTCCACCTCGCCAAAAGACAATTTTTGAAAGATGAATGTTACCAAAACATCAAGAAACTGATAATTCCTGTCTTATAGAAACTTTGAAATGAGAGAAAGCTACCCAACCCATTTCAGAAAGTTAGTAAAATCTCAAAGCTACACTTGA GCAAAGACTGTGAAATATTAATAGACCAATCTTGTTTATGAACATAGATGGAAAAATTGCTGATGAAATATTGGCACATTGAATGTAGCAGTGCATAAAATATTGTATCATGAGCAAAAGGAGAATCTTTCCCAGGAACAGGAGGATGTT TTAATAAAAATATGTAATTTACCTCTCTACAGATTAAAGGAGAAAAACTATATGATCACATCAACAGAAACAGGAAATTCAGTTTCTTTGGGGGATAGTTGTAATTAAAAGTGCTTAACTCACTTATATAAGCCATTAGTGGATGTTACA ATAAACCTCGTATAGTGTCAGATGTAAGACAGACATACTGGAATTGTCTATGAGGTTGGATCCATGGGCCTGCCATGGAAAATTTGTTGAGTAATACGTCCAAGGCGTCACCATTTGCCAGGCGTTGCAAGTATCACCATTTGCAAGGTG TTAACAAAAAGTTACCTGCCTATGGATTCTCCTTTCTAACTCTGACCTAATATTTTGGAGCATAGAGGAAAGAAACATCTTATGTTTCTGTGTTTGGGTAAACATTAGACTTATAAAAGGGCCTAGGGTTTTTTTGTTTGGTAAACCATT GCCTTTCCTGCTTTGGTGTGGCAAATCTTCCTTTGGAGAAAAAGGTCCCTTTAATCTTAAAACCAACTCTCAGTGACCAACAAAAGCAACAAATAGGAACAACCACCCATTAAGAACCATCAGGTGATGCCTCATTTGCTGTGGTGCACA GCTGAACTTGATTGTTACTCTTGGATCAGGGTTGGCTTGATAAGGACTCACTTAACCAATGGAAAGTAAGGTTAAATCTTTGTAAGCAATGCTCCTGATGCGAATCACCTGGAGATCTTGAGCAAATGCAGACTGGTTCAGCAGATCTGG AGTGGGGCCTGAGATTCTGCATTTCTAACAAGTTTCCTGGTGATATTAATGCTGCTGGTCTGTGAGCCATACTTTGAGTAGCAAAGGACTAAAGGTTGTGAGATAAACTGCTTTTAGCAGCCCAAAGGGCCAGCTGGAAAGACGAGACCA GTTACAGAGCAAATGGCAAGACAGATCTGGTAATCTGATTCTTAGAGTACTTAAAAAAGATAAGAAGGATCTATTCCTGATATACAGGGTACTTGGTGGATGTGTCCATGACCTCGAGATCGAAAACCCATTAGTTAATCTTTGTGACAT CTGAATTTTAAGGATCTTACCCAGTGAACATATAACTAGTGGAAATCCTGATAATTGGCTAATGCAAGGAAGTGATACCCATGTGTAATGCTTATCTTTGTATCCATTTCATGGGGAAGGTCATGGAAGACGACAGCAAACTTGAGTGGT TAATGAGAGCTTCACTAATGTTGTCTGCTGCAGGCAATAAGTGAAGTCTCTGGCAGTGGGAAGCATGGACCCAAGACCGAAAGCTCTGGCACTTTATAGCAGTGGTGGGGGGTAGATAGGACTTAGTGTGGCCCCTTAAAGAGCAAGGTC CAAGTGATTTTCTCTGGTGAATGTCGATGTGGATCTAGTCTCCAGGGTTAGATCCAGGCAGGTAACATCAAAGTCAGTTGATAAGACCTCTTATGCCTGTGAATGGAAGGCCCTGATAAAACTTCATTATTAATGTTCTGCATTAATTTA GCGGATGACTATAGTCATTTCACATAATCTAATACATGAATGTCCTGTATGGGTGACTGCTGAGGGTTTAACAAAGGAGAGTCCATTTATATTTGGCTGGTAAGATCGATGCTTCTGTCACTACTGATGGGCAAGGATATTAACATCAAT ATCTAAAAAAATTCTGAGATTTGGATTGTGATGTGTTAAATTTCTAGACCAATTTGAGGAGAATTTAACAATAGCTTTTCAATTTATGAACATGGCGTATATCTTTTTTGGCGGGGGGTGAGGACAGAGTCTTGCTCTGAGATTACCCAG GCTGGAGTTTAGTAGCATGATCTTGGCTCACTGCAACCTCTGCCTCCTGAGTTGAAGCAATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGATTACAGGCGAGCGCCATCATGCCTGACTAATTTTCGTATTTTTAGCAGAGACAGGGTG TCGCCACCTCAAGGGATCCACCTGCCTTGGCCTCCCAAAGTGCTGGGATTTATAAGCGTGAGTCACCGTACCTGGCCAGACATAGCATATATCTTCCTTTACATAGATTGCCTTTGATTTCTTTCATTGTTACTTTGTAGTTTTCAGCTT ACAGATTCCGCGCATATTTTGTTAGACTTAAATCTAAGTATTTGCTTTTTTTTTAACTTACAAATTTTTTTAAAAAAACGTTTTTCCTCTCCAATGTTCATTGCTAATACATTTCACGTTTGAATCTCCAGTTCAGAAAAATCATGGCCT CTGGAGTTTTACTGAGGACTAGAGATAGCTAAGTAACATAGTTCCACCTTATTCACTTGGTCTTTGATGTGGTGTCCATAATTGAGTAAATGGCAGTATGTCCAATGGCAACACCATGAACTTGACTTTGCCCTCTTGTCTAGCCCTCTC CATTTAGACTTGGAAGGGTCAGCAGTAAAATTTCACTGGCCCAGTCCAGGGCTGCTTGAGTGTTACTGTTTTGTGCCACAATATGATGTGGCCAGACTACTTTTCTAGTTTCGAGATTATTTTGGAGCTTTATATTGGGTATGTTCTTAT CCAACTATCATTAGGGGCATTGATCTCTGATGCCCTTTTCTTTCTTATCTTCCAAATGGCAGGCAGTAAATGGCTTATTAAGCAAGTATAAGATTCAAGATCTCAGCCCCAAAGATACATTTGTAGATGCCAGGCTTAACATTCCTGAGG CTCTCAGAGAAAACTTTTCCCTCTATAGACTCCCCATTTTAAGAAGGAGGCACAGGGCTTGGTTGGCCCATTTAGTTAGTGACACACCTATATTACTCTCCTTGGCATCTTACCCCAGCCCATCCATTGGGTTGTGTCAGTCTTTTATTT CTAAGTGAGGATCCAGTCAACAGGAGGCACAAGAGATAGAACCAAATACCATAATGCCTCCTTCTATTCCACTATGAACAGTCAAGGACACTGGAGGCCTCTGGGTGGGACACATAGGCGTTCAAGAGCCTCTGAGCTTAAAGATATGTG AGTGGAGCTAACTAGACTGTCCAGGTTTGGTCTACACTGTAATTTTTTTTTTTTTTTTTTTTTTTTGGAAGCAGAGTCTTGCTCTTTTGCCCAGGCCAGAGTGTAGTGGTGTGATCTCAGCTCAGTGCAGCGTCTGCTTCCTGGGTTCAA GTGATTCTCCTGCCTCAGCCTCCAAGTAGCTGGGACTACAGGTGCCTGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTGGCCAGGCTGGTCTCGAACTCCTGAGCTCAAGTGATCCTCCTGCCTT GGCCTCCCAAAGTGTTGGGATAGCAGGCATGAACCACCGTGCTCAGCCTCTCTGTAAATCTTGAGTCGGCACTGAGCTCATGAAAGCTGTGCTGAGTGGGTTTCTTTAGATTTTCATTTTCATGTTTGCCCCATTTATGCTAATATTAAT TATTGGAAAATAATTCACCTACTTTGCTTCTCTCTGACCAACATAGGGGCAGGATCTGTGGAAAGACATTTACCACCTGTTTGAAAAGGTCAGCGTGCTGATATTCACTAACTACTACCCCCACAACTCCCCCTCCCCCAAACCTGATAG ATGCTATAATTTCTGCAGTCCAATCACTATTCTTCCCAAACTCCATGAGCCAGATTTTATACATACTTTGCGTGACCATAAAACTCTGTACTATTATAGACATAAAACCATTTAATTTCATAGATACCTTCAGTGGTGGCATCACTGGGT CCTCTCTTGGATAGCATAGTCCTATGACCAAATGGGTCAGTCGTTGATCAGGCTTCATGAGAATATGATCGCTGGGAGAAATATACAGCTAATTTAACAACAAATGACTGTCCTAATTCTGGAGACCTGGGAAGTATTGATGAGAGTATA GTGATCATAAGCAGACATTGGGTGCTTTAGCAAAGCCAATTTGCCTGCATCCTCTGGAAGGTAAAGAAGATCTCCTCTCTCTTAGAACTTAATCAAACTCTTGGCATCCACAGAAGGCTAGGAGGATGTAATGAATACTTACCATTTTTG TGGAAGCCCACAACCTTTTGAATGGCCTTTCTATACTTTAGTGAACCTCCATGTTATGAACCTTACTTCCTCAAGTCTCTTTTGCTGCTAGGAGGCAGACAGTAACTTCGGTAATTAGAAACATCTGCACTCAGCAACATGAAGCACAAG TTCTGTGCAGTTGTCCATATGCTGTCATGAGTTTTGCCATATGTATCATCTGGCTTTCAGAGGACCTTTCATGGTTGTCAGGTTAAGTTCCTGATACAGAAGTGGCATCAGTGCTGGTGTTAATGGCTGCAGTAAAGTCAAATTCCTAGA TTTTAGTGCTCTGTGGTAGCAGAGAGAATGGTGGTAGTTTATTTTTTCTTTCCTTTTTTTTTTAAAAAAAAAAAAAAACCTTTTTCATGTTGAAGTTCACATGACCTACAACTAACCATTTTAAAGTGTAATTCAGTGTCATTCAGTACA TCCACAATGTGCAATCACCACCTCTGTCTAGTTCCAAAACATTTTTATCACCCTAAAAGGAAACCTTGCACCCATTAAACAGTGGTAGTTTCTCTATCATGCCACTTTTGTAGCATGCTTTGGGGTCTTATTCCTGGGATCTTTCTCTAC AGTGGTATGATTATATAAGGGTGGAAATATAAAAGAGTAAGCCTTTAGAAACAGTTTGTGTCTAAATTAGCTCTCAGGCATATTGTCTTCAAAGGAATGTTTTAAACCAGCCAAAGACTAACATCAACATGCTTACATTTTGAGTCCAAA ATTAAAATCCAAAATAGCCAAGCATGGTGGCTCACGCCTATAATCCCAACTACTCCAGAGGCTGAGGTGTGATAGAATTTCTTGAACCTAGGCGTTCCAGGCTGCAGTGAGCTATGATTGTGCTGCTGCACTCCAGCCTGGGTGACAGAG CGAGGTTGCTTCTAAAACAAAAATTTGAAATAGTAAGTGCTTTGATTTTTTTTAATATAGAATCAAACAATTGTGAAAATATAATTGGCTAAGTTTCATATACAGTTCTTTCTAAAACTCCTTCTGTTCTCTAAGATGTAGTTTGAACCA GCCAAGGATGATGGCTTCAACATGTCTCCAGTTGTTTTGCCACTCCAGGGCCTGACTCAAACCAAAATAAGACTTGCTGTTACCCTGAGACAAGCCAACTGTCATTGCTTTAGCAACCACTACGGCTACAGGTTGTTGCATCATGCCAAG CTCTGTGTTCTTTCTAACTAGTAGAATGGAGTGGGATGGTATCGTGATGGTGAACCCAAAACAATGGTACTAGGAAGGAGGTTGGCCAAACTCAGAGTGGAGGCTGACCCTGTATCTGGTTGTAGCAGAGTCGGTCCTAGGGGAACAGGC TCAGCAGCAGCAAGGATGCAAGGACCAGAAGGCAGCAGGGGAAGGAAAAGGAGCAGGGGATAGGGGAACTTTAGGAGCAGAGTAGTGTTGATAACTGGCATCTGGAACCTACAGTTTCCAGTTCAGAGCAGTACACCATACTCAGTGTAT ACTTACACTCCAAGACATTTCCTGGGCAGTGATCTAGAAATGATATTTTTAAAAGGAGCTGTGTTTCAGTGTTAGACTGTAGTTATCCAAGCAGTATCAGATAGTGTGCAGTTTTTGTAGTAAAAGGTAAAAATCTGAATAATAAAGTTT ATTAATAACAGTTTTAGTTAATACTTGACTGACATTGAGACCCTTGATGCAAAAAGGTAAGTAGAAGAGAAGGCTGTAAACACAAGACCATCATACCCTGTGGGGAATTTACAATCTAAATATAACAAACATATAGAGTGAGATAGGAGA AAAGAAATGGGATGATAATGATATTGCTGTACTAAAGTCTATTTAGGAAATGGAAATATATAGCAAGAGGAGTCAGCTACTTGGGCATTGATCAAAGAAAAATAAACATATAGAAGGAAAGAAAGGTCGTTTTAGTTTATAACATTTTCC TTCCGATTCTAGGTGATTATATAGCTAGTTTACTCTTCCACCCCCAAGATTCTGGGGTATTTTGGCTAATGTTATTTGCAATGTCCATAAACTCAGAAGAAGTTAGTATTAACGGGGATATGAAAGAACCTCCAGTTACTATGCAAGAAA TTTTAAATTTCCATCATGTTAAATTGTACAACTGTTTATCATTCACTCTGCTGTAAGTCTATGTGAAACCAAATCCGTGGATTTACCAATGGCCATTTTATCACCTCCAAACTATCTTTTATTTTTTTGAATTGTATCTCTCTCCTTATT CCATTTTCTTCTGTTTGATTAAAATCCTGCATGTTCTCCTGCA >DPP4_PDK1_ENST00000360534_ENST00000392571_162902041_173451005 length=1293nt Breakpoint=927nt CTTTCACTGGCAAGAGACGGAGTCCTGGGTTTCAGTTCCAGTTGCCTGCGGTGGGCTGTGTGAGTTTGCCAAAGTCCCCTGCCCTCTCTGGGTCTCGGTTCCCTCGCCTGTCCACGTGAGGTTGGAGGAGCTGAACGCCGACGTCATTTT TAGCTAAGAGGGAGCAGGGTCCCCGAGTCGCCGGCCCAGGGTCTGCGCATCCGAGGCCGCGCGCCCTTTCCCCTCCCCCACGGCTCCTCCGGGCCCCGCACTCTGCGCCCCGGCTGCCGCCCAGCGCCCTACACCGCCCTCAGGGGGCCC TCGCGGGCTCCCCCCGGCCGGGATGCCAGTGCCCCGCGCCACGCGCGCCTGCTCCCGCGCCGCCTGCCCTGCAGCCTGCCCGCGGCGCCTTTATACCCAGCGGGCTCGGCGCTCACTAATGTTTAACTCGGGGCCGAAACTTGCCAGCGG CGAGTGACTCCACCGCCCGGAGCAGCGGTGCAGGACGCGCGTCTCCGCCGCCCGCGGTGACTTCTGCCTGCGCTCCTTCTCTGAACGCTCACTTCCGAGGAGACGCCGACGATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGT GCTGCTGCGCTTGTCACCATCATCACCGTGCCCGTGGTTCTGCTGAACAAAGGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTATAGACTGAAGTTATACTCCTTAAGATGGATT TCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATATGGAAACAGCTCAGTTTTCTTGGAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTT ATTCTCTTAGAATACAACTACGTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTATTCAACTGCACCAAGACCTCGTGTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGT TATGGATTGCCCATATCACGTCTTTACGCACAATACTTCCAAGGAGACCTGAAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCAATAGAAAGACTCCCAGTGTATAACAAAGCT GCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAACCCAAAGACATGACGACGTTCCGCAGTGCCTAG >DPP4_PDK1_ENST00000360534_ENST00000410055_162902041_173451005 length=2869nt Breakpoint=927nt CTTTCACTGGCAAGAGACGGAGTCCTGGGTTTCAGTTCCAGTTGCCTGCGGTGGGCTGTGTGAGTTTGCCAAAGTCCCCTGCCCTCTCTGGGTCTCGGTTCCCTCGCCTGTCCACGTGAGGTTGGAGGAGCTGAACGCCGACGTCATTTT TAGCTAAGAGGGAGCAGGGTCCCCGAGTCGCCGGCCCAGGGTCTGCGCATCCGAGGCCGCGCGCCCTTTCCCCTCCCCCACGGCTCCTCCGGGCCCCGCACTCTGCGCCCCGGCTGCCGCCCAGCGCCCTACACCGCCCTCAGGGGGCCC TCGCGGGCTCCCCCCGGCCGGGATGCCAGTGCCCCGCGCCACGCGCGCCTGCTCCCGCGCCGCCTGCCCTGCAGCCTGCCCGCGGCGCCTTTATACCCAGCGGGCTCGGCGCTCACTAATGTTTAACTCGGGGCCGAAACTTGCCAGCGG CGAGTGACTCCACCGCCCGGAGCAGCGGTGCAGGACGCGCGTCTCCGCCGCCCGCGGTGACTTCTGCCTGCGCTCCTTCTCTGAACGCTCACTTCCGAGGAGACGCCGACGATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGT GCTGCTGCGCTTGTCACCATCATCACCGTGCCCGTGGTTCTGCTGAACAAAGGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTATAGACTGAAGTTATACTCCTTAAGATGGATT TCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATATGGAAACAGCTCAGTTTTCTTGGAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTT ATTCTCTTAGAATACAACTACGTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTATTCAACTGCACCAAGACCTCGTGTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGT TATGGATTGCCCATATCACGTCTTTACGCACAATACTTCCAAGGAGACCTGAAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCAATAGAAAGACTCCCAGTGTATAACAAAGCT GCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAACCCAAAGACATGACGACGTTCCGCAGTGCCTAGACACACTTGGGACATCGGAAAATCCAAATGTGGCTTTTGTATTAAATTTGGAAGTGT GGCCCAGAGTTGCTCAGAATTGGAGCAGAGCCTGAGACGTATCTGCAGATCCTGTCATCAGCTGGCAAGTCCAGGAGACTGTGTCATTTAGAGACTGTGTTGTTAGTTATCCCTCAACATCTTCTAAGGTGGCAGGAAATAATATTGGAA ATAACATTTTAAAGTAAAAATTTTAAAGTTTAAAGAAGAGTTTTGCCACTTAAACAGGGGAGCTTTGTCTGGAAAATACACTGAGTTGAAACACTTCATCCTTGGAAGGATTATATAAGATGAACAGTTGTGATAAATGTGTAGATTAGA GGGATGTGAATGGGCAGTTAGTCCAGTGCCCTCATTTAAGAGGCCAAGATCCTGATTCAGAGGAGGCATCCTTTGCCCAGAGCTGCTTAGCTAATCTGACCAAATGTTGGGAAAAATGTCTCACCTAACCCACTATTCCTTAATTATGGA TTTTGTGAAAAACAATAGAACATGTTAATGAGTAATTTATATTAGTTCGATGTATTACAATTTTTTAGCTTTAAATTACAGTTTTCTTATAATGTTGAAATGTTTTAGAATCCTTTGAATCTAAGTATTTGTTTCCTAAATGAAACATTT GTACAACATTTGATGTTTTTACTTATGAAATATTCTCCTCCCCCAAGAAAATTTAAACTTTTTCTCTCTATTTAAAAGCTAAGAAATGTTTTAAAGGAAAAATGAAATTATCTTCCTTTAGCTTATTTTTAAGGTAAAACAGCTTTTTAC TCTGTTATTGTGGTAATGGACAGAATATTACATACAAAAATATTCTGGGAGAGCTTTTTCCTAGTTGGTTTTAAATCATTGTGCCACCTGAAAGGTTTTTAGATTTTATAGGAGCTAATTTGTCCACCAGCATTAATGTAACACAGTGTA GTTATGAAAATATATTGAAGGACAGGAAGTGGACACGAAGTGATTTTTGTAACCTGAGCAGTTAATGAATGTGCCAACATTTTCTAGGAAGGGACAGCAAGAATATTCTGCTCTGTAGTTAAAATACTGGCTGGCTTTTGATGTCTTCAT GCTTAATTGTGATCACTTTCTTGCACTGTGATGTTTTTACGTGAATATGTTGAAGTAGAAGTCTACCATATTATTTTATAAAATGTTTTCTGTATGGCAATAAACTGAAAACATGGATCAACCCTTCTTTTGAAAATAAACTGAGTCAAT TTAGCCTTTTAAAAATATAGTCATCTCTTTTAAATAGAATCCTCTTCCACCATCAAGGCTCAACATTTTGTAAGCATCCAAAAAATTGGTAATTAGGGGGCTTGCACTAAATTTCACTATCTTCAGTAGAGAGGAACTGTTTGGAACTTA GATTTCCAATGTGTATATTCTAATGGAGAAAGCAAGAGGTAGAGTTTGTATGTTTGACTTACCTTAGATTTTTATTTTCCATACATACTGCAAATGATTGACTTGTTGCATAAATGAAGATCTTCTGTTGTGTGCTTTTCAAACACTGTA AATAAATTTGAAATTTGAA >DPP4_PDK1_ENST00000360534_ENST00000543905_162902041_173451005 length=1579nt Breakpoint=927nt CTTTCACTGGCAAGAGACGGAGTCCTGGGTTTCAGTTCCAGTTGCCTGCGGTGGGCTGTGTGAGTTTGCCAAAGTCCCCTGCCCTCTCTGGGTCTCGGTTCCCTCGCCTGTCCACGTGAGGTTGGAGGAGCTGAACGCCGACGTCATTTT TAGCTAAGAGGGAGCAGGGTCCCCGAGTCGCCGGCCCAGGGTCTGCGCATCCGAGGCCGCGCGCCCTTTCCCCTCCCCCACGGCTCCTCCGGGCCCCGCACTCTGCGCCCCGGCTGCCGCCCAGCGCCCTACACCGCCCTCAGGGGGCCC TCGCGGGCTCCCCCCGGCCGGGATGCCAGTGCCCCGCGCCACGCGCGCCTGCTCCCGCGCCGCCTGCCCTGCAGCCTGCCCGCGGCGCCTTTATACCCAGCGGGCTCGGCGCTCACTAATGTTTAACTCGGGGCCGAAACTTGCCAGCGG CGAGTGACTCCACCGCCCGGAGCAGCGGTGCAGGACGCGCGTCTCCGCCGCCCGCGGTGACTTCTGCCTGCGCTCCTTCTCTGAACGCTCACTTCCGAGGAGACGCCGACGATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGT GCTGCTGCGCTTGTCACCATCATCACCGTGCCCGTGGTTCTGCTGAACAAAGGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTATAGACTGAAGTTATACTCCTTAAGATGGATT TCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATATGGAAACAGCTCAGTTTTCTTGGAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTT ATTCTCTTAGAATACAACTACGTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTATTCAACTGCACCAAGACCTCGTGTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGT TATGGATTGCCCATATCACGTCTTTACGCACAATACTTCCAAGGAGACCTGAAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCAATAGAAAGACTCCCAGTGTATAACAAAGCT GCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAACCCAAAGACATGACGACGTTCCGCAGTGCCTAGACACACTTGGGACATCGGAAAATCCAAATGTGGCTTTTGTATTAAATTTGGAAGATT CTTCAGTTTTGGGACTTGGACTGGCTTTCCTTGCCCCTCAGCTTGCAGATGGCCTGTTGTGGGACCTTGTGATCATGAACTCCTCCTCCCACATCTGATGGAGCTACCAATCATCAGATCTCCTCTGCCTCTGGGGTGCGTCTCAGGCTG GCCAATCACGTTCTTCATCCACGTGGACTATGACTGGCCCTAGGGAGAAAACATGGAGATATGAATGACTGTGTGGAGC >DPP4_PDK1_ENST00000360534_ENST00000544863_162902041_173451005 length=1342nt Breakpoint=927nt CTTTCACTGGCAAGAGACGGAGTCCTGGGTTTCAGTTCCAGTTGCCTGCGGTGGGCTGTGTGAGTTTGCCAAAGTCCCCTGCCCTCTCTGGGTCTCGGTTCCCTCGCCTGTCCACGTGAGGTTGGAGGAGCTGAACGCCGACGTCATTTT TAGCTAAGAGGGAGCAGGGTCCCCGAGTCGCCGGCCCAGGGTCTGCGCATCCGAGGCCGCGCGCCCTTTCCCCTCCCCCACGGCTCCTCCGGGCCCCGCACTCTGCGCCCCGGCTGCCGCCCAGCGCCCTACACCGCCCTCAGGGGGCCC TCGCGGGCTCCCCCCGGCCGGGATGCCAGTGCCCCGCGCCACGCGCGCCTGCTCCCGCGCCGCCTGCCCTGCAGCCTGCCCGCGGCGCCTTTATACCCAGCGGGCTCGGCGCTCACTAATGTTTAACTCGGGGCCGAAACTTGCCAGCGG CGAGTGACTCCACCGCCCGGAGCAGCGGTGCAGGACGCGCGTCTCCGCCGCCCGCGGTGACTTCTGCCTGCGCTCCTTCTCTGAACGCTCACTTCCGAGGAGACGCCGACGATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGT GCTGCTGCGCTTGTCACCATCATCACCGTGCCCGTGGTTCTGCTGAACAAAGGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTATAGACTGAAGTTATACTCCTTAAGATGGATT TCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATATGGAAACAGCTCAGTTTTCTTGGAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTT ATTCTCTTAGAATACAACTACGTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTATTCAACTGCACCAAGACCTCGTGTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGT TATGGATTGCCCATATCACGTCTTTACGCACAATACTTCCAAGGAGACCTGAAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCAATAGAAAGACTCCCAGTGTATAACAAAGCT GCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAACCCAAAGACATGACGACGTTCCGCAGTGCCTAGACACACTTGGGACATCGGAAAATCCAAATGTGGCTTTTGTATTAAATTT |
| N-Truncated Transcript (5UTR-3CDS) Sequences |
| C-Truncated Transcript (5CDS-3UTR) Sequences |
Top |
Fusion Protein Sequence for DPP4_PDK1 |
| In-frame Fusion Protein Sequences. |
| N-Truncated Protein (5UTR-3CDS) Sequences |
| C-Truncated Protein (5CDS-3UTR) Sequences |
Top |
Personalized Fusion Protein Sequence for DPP4_PDK1 |
| TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| TCGA All Mutated Fusion Protein Sequences |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
| CCLE All Mutated Fusion Protein Sequences |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
Top |
Fusion Gene Exprssed Samples for DPP4_PDK1 |
| RNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB | KIRP | TCGA-Q2-A5QZ-01A | DPP4 | chr2 | 162902041 | - | PDK1 | chr2 | 162902041 | + | |
| ChimerDB | KIRP | TCGA-Q2-A5QZ | DPP4 | chr2 | 162902041 | - | PDK1 | chr2 | 162902041 | + | |
| WashU | KIRP | TCGA-Q2-A5QZ-01A | DPP4 | chr2 | 162902042 | - | PDK1 | chr2 | 173451006 | + | |
| cBioPortal | KIRP_TCGA_PAN_CAN_ATLAS_2018 | PRCC | TCGA-Q2-A5QZ-01 | DPP4 | chr2 | 162045532 | PDK1 | chr2 | 172586278 |
| DNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | SV type |
Top |
Related Drugs for DPP4_PDK1 |
| PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug'] * For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub. |
| PMID | Fusion Gene Name | Drug | Study Title |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies