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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:AHCY_PIGU (FusionGDB2 ID:HG191TG128869)

Fusion Gene Summary for AHCY_PIGU

Fusion gene summary

Fusion gene information	Fusion gene name: AHCY_PIGU
	Fusion gene ID: hg191tg128869
		Hgene	Tgene
	Gene symbol	AHCY	PIGU
	Gene ID	191	128869
	Gene name	adenosylhomocysteinase	phosphatidylinositol glycan anchor biosynthesis class U
	Synonyms	SAHH\|adoHcyase	CDC91L1\|GAB1\|GPIBD21\|NEDBSS\|PIG-U
	Cytomap	20q11.22	20q11.22
	Type of gene	protein-coding	protein-coding
	Description	adenosylhomocysteinaseS-adenosyl-L-homocysteine hydrolaseS-adenosylhomocysteine hydrolaseepididymis secretory sperm binding protein	phosphatidylinositol glycan anchor biosynthesis class U proteinCDC91 (cell division cycle 91, S. cerevisiae, homolog)-like 1GPI and Actin Bar homologGPI transamidase component PIG-UGPI transamidase subunitGPI transamidase subunit PIGUcell division c
	Modification date	20240407	20240403
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000217426, ENST00000538132, ENST00000468908,	ENST00000468908, ENST00000217426, ENST00000538132,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 12 X 10 X 9=1080	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 12 X 12 X 14=2016
	# samples	13	29
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(13/108010)=-3.05444778402238 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(29/201610)=-2.79737083348498 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AHCY [Title/Abstract] AND PIGU [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AHCY(32881886)-PIGU(33245048), # samples:1

Fusion gene breakpoints across AHCY (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PIGU (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for AHCY_PIGU

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
AHCY	chr20	32881886	PIGU	chr20	33245048

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	SV type
AHCY	chr20	32883308	PIGU	chr20	33238981	DEL
AHCY	chr20	32890337	PIGU	chr20	33238981	DEL

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for AHCY_PIGU

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
AHCY-PIGU	Promoter / Enhancer Hijacking M6		AHCY promoter drives elevated GPI transamidase subunit PIGU expression, increasing cell-surface attachment of pro-invasive GPI proteins.		GPI biosynthesis inhibitors; cell-adhesion antagonists		Bladder and breast carcinomas

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
AHCY-PIGU	Promoter / Enhancer Hijacking		AHCY promoter drives elevated GPI transamidase subunit PIGU expression, increasing cell-surface attachment of pro-invasive GPI proteins.	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 32971102; Title: PIGU promotes hepatocellular carcinoma progression through activating NF-ÎºB pathway and increasing immune escape.	GPI biosynthesis inhibitors; cell-adhesion antagonists		Bladder and breast carcinomas	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 30171988; Title: PIGU overexpression adds value to TNM staging in the prognostic stratification of patients with hepatocellular carcinoma.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PIGU	GO:0006506	GPI anchor biosynthetic process	15034568
Tgene	PIGU	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	15034568

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Fusion Genomic Features for AHCY_PIGU

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
AHCY	chr20	32881886	-	PIGU	chr20	33245048	-	6.28e-03	9.94e-01

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
AHCY	chr20	32881886	-	PIGU	chr20	33245048	-	6.28e-03	9.94e-01

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for AHCY_PIGU

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000468908	ENST00000374820	AHCY	chr20	32881886	-	PIGU	chr20	33245048	-
5UTR-3CDS	ENST00000468908	ENST00000452740	AHCY	chr20	32881886	-	PIGU	chr20	33245048	-
Frame-shift	ENST00000217426	ENST00000452740	AHCY	chr20	32881886	-	PIGU	chr20	33245048	-
Frame-shift	ENST00000538132	ENST00000374820	AHCY	chr20	32881886	-	PIGU	chr20	33245048	-
In-frame	ENST00000217426	ENST00000374820	AHCY	chr20	32881886	-	PIGU	chr20	33245048	-
In-frame	ENST00000538132	ENST00000452740	AHCY	chr20	32881886	-	PIGU	chr20	33245048	-

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000217426	ENST00000374820	AHCY	chr20	32881886	PIGU	chr20	33245048	373	497
ENST00000538132	ENST00000452740	AHCY	chr20	32881886	PIGU	chr20	33245048	598	998

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000468908	ENST00000374820	AHCY	chr20	32881886	PIGU	chr20	33245048	0	590
ENST00000468908	ENST00000452740	AHCY	chr20	32881886	PIGU	chr20	33245048	0	366

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000217426	ENST00000374820	AHCY	chr20	32881886	PIGU	chr20	33245048	2.23e-04	1.00e+00
ENST00000538132	ENST00000452740	AHCY	chr20	32881886	PIGU	chr20	33245048	4.97e-04	1.00e+00

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000468908	ENST00000374820	AHCY	chr20	32881886	PIGU	chr20	33245048	0.00e+00	3.15e-03
ENST00000468908	ENST00000452740	AHCY	chr20	32881886	PIGU	chr20	33245048	0.00e+00	2.67e-03

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for AHCY_PIGU

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

AHCY_PIGU_chr20-32881886_chr20-33245048.png

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PIGU

chr20:32881886

chr20:33245048

ENST00000374820

Q9H490

100_136

43.333333333333336

416.0

Topological domain

Cytoplasmic

Tgene

PIGU

chr20:32881886

chr20:33245048

ENST00000374820

Q9H490

206_222

43.333333333333336

416.0

Topological domain

Cytoplasmic

Tgene

PIGU

chr20:32881886

chr20:33245048

ENST00000374820

Q9H490

245_286

43.333333333333336

416.0

Topological domain

Lumenal

Tgene

PIGU

chr20:32881886

chr20:33245048

ENST00000374820

Q9H490

307_311

43.333333333333336

416.0

Topological domain

Cytoplasmic

Tgene

PIGU

chr20:32881886

chr20:33245048

ENST00000374820

Q9H490

346_354

43.333333333333336

416.0

Topological domain

Cytoplasmic

Tgene

PIGU

chr20:32881886

chr20:33245048

ENST00000374820

Q9H490

373_384

43.333333333333336

416.0

Topological domain

Lumenal

Tgene

PIGU

chr20:32881886

chr20:33245048

ENST00000374820

Q9H490

407_435

43.333333333333336

416.0

Topological domain

Cytoplasmic

Tgene

PIGU

chr20:32881886

chr20:33245048

ENST00000374820

Q9H490

137_158

43.333333333333336

416.0

Transmembrane

Helical

Tgene

PIGU

chr20:32881886

chr20:33245048

ENST00000374820

Q9H490

159_178

43.333333333333336

416.0

Transmembrane

Helical

Tgene

PIGU

chr20:32881886

chr20:33245048

ENST00000374820

Q9H490

179_194

43.333333333333336

416.0

Transmembrane

Helical

Tgene

PIGU

chr20:32881886

chr20:33245048

ENST00000374820

Q9H490

195_205

43.333333333333336

416.0

Transmembrane

Helical

Tgene

PIGU

chr20:32881886

chr20:33245048

ENST00000374820

Q9H490

223_244

43.333333333333336

416.0

Transmembrane

Helical

Tgene

PIGU

chr20:32881886

chr20:33245048

ENST00000374820

Q9H490

287_306

43.333333333333336

416.0

Transmembrane

Helical

Tgene

PIGU

chr20:32881886

chr20:33245048

ENST00000374820

Q9H490

312_331

43.333333333333336

416.0

Transmembrane

Helical

Tgene

PIGU

chr20:32881886

chr20:33245048

ENST00000374820

Q9H490

332_345

43.333333333333336

416.0

Transmembrane

Helical

Tgene

PIGU

chr20:32881886

chr20:33245048

ENST00000374820

Q9H490

355_372

43.333333333333336

416.0

Transmembrane

Helical

Tgene

PIGU

chr20:32881886

chr20:33245048

ENST00000374820

Q9H490

385_406

43.333333333333336

416.0

Transmembrane

Helical

Tgene

PIGU

chr20:32881886

chr20:33245048

ENST00000374820

Q9H490

79_99

43.333333333333336

416.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PIGU

chr20:32881886

chr20:33245048

ENST00000374820

Q9H490

23_78

43.333333333333336

416.0

Topological domain

Lumenal

Tgene

PIGU

chr20:32881886

chr20:33245048

ENST00000374820

Q9H490

2_3

43.333333333333336

416.0

Topological domain

Cytoplasmic

Tgene

PIGU

chr20:32881886

chr20:33245048

ENST00000374820

Q9H490

4_22

43.333333333333336

416.0

Transmembrane

Helical

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for AHCY_PIGU

In-frame Fusion Transcript Sequences.

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048 length=1814nt 
 Breakpoint=373nt
CGGCGCTGCCCGCCCAGTTCCTGTTCCCAGACTGAGGCCCAGCCCCCTTCGCCCGTTTCCATCACGAGTGCCGCCAGCATGTCTGACAAACTGCCCTACAAAGTCGCCGACATCGGCCTGGCTGCCTGGGGACGCAAGGCCCTGGACATT
GCTGAGAACGAGATGCCGGGCCTGATGCGTATGCGGGAGCGGTACTCGGCCTCCAAGCCACTGAAGGGCGCCCGCATCGCTGGCTGCCTGCACATGACCGTGGAGACGGCCGTCCTCATTGAGACCCTCGTCACCCTGGGTGCTGAGGTG
CAGTGGTCCAGCTGCAACATCTTCTCCACCCAGGACCATGCGGCGGCTGCCATTGCCAAGGCTGGCATTCCGGTGGTTGAAGGCCTTTCACTGTTGGACTTGGGAGTATCTCCGTATTCTGGAGCAGTATTTCATGAAATAACTGATGCA
CTCACTGCTATTGCCCTGTATTTTGCAATCCAGGACTTCAATAAAGTTGTGTTTAAAAAGCAGAAACTCCTCCTAGAACTGGACCAGTATGCCCCAGATGTGGCCGAACTCATCCGGACCCCTATGGAAATGCGTTACATCCCTTTGAAA
GTGGCCCTGTTCTATCTCTTAAATCCTTACACGATTTTGTCTTGTGTTGCCAAGTCTACCTGTGCCATCAACAACACCCTCATTGCTTTCTTCATTTTGACTACGATAAAAGGCAGTGCTTTCCTCAGTGCTATTTTTCTTGCCTTAGCG
ACATACCAGTCTCTGTACCCACTCACCTTGTTTGTCCCAGGACTCCTCTATCTCCTCCAGCGGCAGTACATACCTGTGAAAATGAAGAGCAAAGCCTTCTGGATCTTTTCTTGGGAGTATGCCATGATGTATGTGGGAAGCCTAGTGGTA
ATCATTTGCCTCTCCTTCTTCCTTCTCAGCTCTTGGGATTTCATCCCCGCAGTCTATGGCTTTATACTTTCTGTTCCAGATCTCACTCCAAACATTGGTCTTTTCTGGTACTTCTTTGCAGAGATGTTTGAGCACTTCAGCCTCTTCTTT
GTATGTGTGTTTCAGATCAACGTCTTCTTCTACACCATCCCCTTAGCCATAAAGCTAAAGGAGCACCCCATCTTCTTCATGTTTATCCAGATCGCTGTCATCGCCATCTTTAAGTCCTACCCGACAGTGGGGGACGTGGCGCTCTACATG
GCCTTCTTCCCCGTGTGGAACCATCTCTACAGATTCCTGAGAAACATCTTTGTCCTCACCTGCATCATCATCGTCTGTTCCCTGCTCTTCCCTGTCCTGTGGCACCTCTGGATTTATGCAGGAAGTGCCAACTCTAATTTCTTTTATGCC
ATCACACTGACCTTCAACGTTGGGCAGATCCTGCTCATCTCTGATTACTTCTATGCCTTCCTGCGGCGGGAGTACTACCTCACACATGGCCTCTACTTGACCGCCAAGGATGGCACAGAGGCCATGCTCGTGCTCAAGTAGGCCTGGCTG
GCACAGGGCTGCATGGACCTCAGGGGGCTGTGGGGCCAGAAGCTGGGCCAAGCCCTCCAGCCAGAGTTGCCAGCAGGCGAGTGCTTGGGCAGAAGAGGTTCGAGTCCAGGGTCACAAGTCTCTGGTACCAAAAGGGACCCATGGCTGACT
GACAGCAAGGCCTATGGGGAAGAACTGGGAGCTCCCCAACTTGGACCCCCACCTTGTGGCTCTGCACACCAAGGAGCCCCCTCCCAGACAGGAAGGAGAAGAGGCAGGTGAGCAGGGCTTGTTAGATTGTGGCTACTTAATAAATGTTTT
TTGTTATGAAGTCT

>AHCY_PIGU_ENST00000538132_ENST00000452740_32881886_33245048 length=1937nt 
 Breakpoint=598nt
CTGGAGGGAGGGGCGTGGATACAGCGGGAAAGGAGAGACCCCTAGCGGGGTGGACAAGAAGGGAGGAACTCCACAGAACTGCTTAATCCGGCTCCATCCCCATCAGCGGGCTTTCTCAGCGCCTGCACCCCTCTCTATCCCATCTCGAAG
CCTCCAGTTAATCCAGAGTGAGACGCAGGACCGCCGGGAGGCGAGCGGGGATGCTGAAGCTAGGGCAGGCTAAAGCCCCGCGGCCAAAGGGCAGGCTTGTGCGCCCTCCGCCCCCTCTCCGCCCCCTCTCCGCCCCTCCGCGCCCAGGAC
CTAATTGTTTGCAAAAGCAAACACGGAAAAGCCGACATCGGCCTGGCTGCCTGGGGACGCAAGGCCCTGGACATTGCTGAGAACGAGATGCCGGGCCTGATGCGTATGCGGGAGCGGTACTCGGCCTCCAAGCCACTGAAGGGCGCCCGC
ATCGCTGGCTGCCTGCACATGACCGTGGAGACGGCCGTCCTCATTGAGACCCTCGTCACCCTGGGTGCTGAGGTGCAGTGGTCCAGCTGCAACATCTTCTCCACCCAGGACCATGCGGCGGCTGCCATTGCCAAGGCTGGCATTCCGGTG
GTTGAAGGCCTTTCACTGTTGGACTTGGGAGTATCTCCGTATTCTGGAGCAGTATTTCATGAAACTCCATTAATAATATACCTCTTTCATTTCCTAATTGACTATGCTGAATTGGTGTTTATGATAACTGATGCACTCACTGCTATTGCC
CTGTATTTTGCAATCCAGGACTTCAATAAAGTTGTGTTTAAAAAGCAGAAACTCCTCCTAGAACTGGACCAGTATGCCCCAGATGTGGCCGAACTCATCCGGACCCCTATGGAAATGCGTTACATCCCTTTGAAAGTGGCCCTGTTCTAT
CTCTTAAATCCTTACACGATTTTGTCTTGTGTTGCCAAGTCTACCTGTGCCATCAACAACACCCTCATTGCTTTCTTCATTTTGACTACGATAAAAGGCAGTGCTTTCCTCAGTGCTATTTTTCTTGCCTTAGCGACATACCAGTCTCTG
TACCCACTCACCTTGTTTGTCCCAGGACTCCTCTATCTCCTCCAGCGGCAGTACATACCTGTGAAAATGAAGAGCAAAGCCTTCTGGATCTTTTCTTGGGAGTATGCCATGATGTATGTGGGAAGCCTAGTGGTAATCATTTGCCTCTCC
TTCTTCCTTCTCAGCTCTTGGGATTTCATCCCCGCAGTCTATGGCTTTATACTTTCTGTTCCAGATCTCACTCCAAACATTGGTCTTTTCTGGTACTTCTTTGCAGAGATGTTTGAGCACTTCAGCCTCTTCTTTGTATGTGTGTTTCAG
ATCAACGTCTTCTTCTACACCATCCCCTTAGCCATAAAGCTAAAGGAGCACCCCATCTTCTTCATGTTTATCCAGATCGCTGTCATCGCCATCTTTAAGTCCTACCCGACAGTGGGGGACGTGGCGCTCTACATGGCCTTCTTCCCCGTG
TGGAACCATCTCTACAGATTCCTGAGAAACATCTTTGTCCTCACCTGCATCATCATCGTCTGTTCCCTGCTCTTCCCTGTCCTGTGGCACCTCTGGATTTATGCAGGAAGTGCCAACTCTAATTTCTTTTATGCCATCACACTGACCTTC
AACGTTGGGCAGATGGGCTTCTGTGGTGATAGAATGGCAGGTACTTGTCCTGAGGCCATCAGAGCTGCTGGTGACAGGACACCTTCCTGAACTCCTCCAGGCGCCTCTGATCTCTCCTTAGCTGCTGTTGTGTTACCTTCAGATCCTGCT
CATCTCTGATTACTTCTATGCCTTCCTGCGGCGGGAGTACTACCTCACACATGGCCTCTACTTGACCGCCAAGGATGGCACAGAGGCCATGCTCGTGCTCAAGTAGGCCTGGCTGGCACAGGGCTGCATGGACCTCA

N-Truncated Transcript (5UTR-3CDS) Sequences

>AHCY_PIGU_ENST00000468908_ENST00000374820_32881886_33245048 length=1441nt 
 Breakpoint=0nt
TGGTTGAAGGCCTTTCACTGTTGGACTTGGGAGTATCTCCGTATTCTGGAGCAGTATTTCATGAAATAACTGATGCACTCACTGCTATTGCCCTGTATTTTGCAATCCAGGACTTCAATAAAGTTGTGTTTAAAAAGCAGAAACTCCTCC
TAGAACTGGACCAGTATGCCCCAGATGTGGCCGAACTCATCCGGACCCCTATGGAAATGCGTTACATCCCTTTGAAAGTGGCCCTGTTCTATCTCTTAAATCCTTACACGATTTTGTCTTGTGTTGCCAAGTCTACCTGTGCCATCAACA
ACACCCTCATTGCTTTCTTCATTTTGACTACGATAAAAGGCAGTGCTTTCCTCAGTGCTATTTTTCTTGCCTTAGCGACATACCAGTCTCTGTACCCACTCACCTTGTTTGTCCCAGGACTCCTCTATCTCCTCCAGCGGCAGTACATAC
CTGTGAAAATGAAGAGCAAAGCCTTCTGGATCTTTTCTTGGGAGTATGCCATGATGTATGTGGGAAGCCTAGTGGTAATCATTTGCCTCTCCTTCTTCCTTCTCAGCTCTTGGGATTTCATCCCCGCAGTCTATGGCTTTATACTTTCTG
TTCCAGATCTCACTCCAAACATTGGTCTTTTCTGGTACTTCTTTGCAGAGATGTTTGAGCACTTCAGCCTCTTCTTTGTATGTGTGTTTCAGATCAACGTCTTCTTCTACACCATCCCCTTAGCCATAAAGCTAAAGGAGCACCCCATCT
TCTTCATGTTTATCCAGATCGCTGTCATCGCCATCTTTAAGTCCTACCCGACAGTGGGGGACGTGGCGCTCTACATGGCCTTCTTCCCCGTGTGGAACCATCTCTACAGATTCCTGAGAAACATCTTTGTCCTCACCTGCATCATCATCG
TCTGTTCCCTGCTCTTCCCTGTCCTGTGGCACCTCTGGATTTATGCAGGAAGTGCCAACTCTAATTTCTTTTATGCCATCACACTGACCTTCAACGTTGGGCAGATCCTGCTCATCTCTGATTACTTCTATGCCTTCCTGCGGCGGGAGT
ACTACCTCACACATGGCCTCTACTTGACCGCCAAGGATGGCACAGAGGCCATGCTCGTGCTCAAGTAGGCCTGGCTGGCACAGGGCTGCATGGACCTCAGGGGGCTGTGGGGCCAGAAGCTGGGCCAAGCCCTCCAGCCAGAGTTGCCAG
CAGGCGAGTGCTTGGGCAGAAGAGGTTCGAGTCCAGGGTCACAAGTCTCTGGTACCAAAAGGGACCCATGGCTGACTGACAGCAAGGCCTATGGGGAAGAACTGGGAGCTCCCCAACTTGGACCCCCACCTTGTGGCTCTGCACACCAAG
GAGCCCCCTCCCAGACAGGAAGGAGAAGAGGCAGGTGAGCAGGGCTTGTTAGATTGTGGCTACTTAATAAATGTTTTTTGTTATGAAGTCT

>AHCY_PIGU_ENST00000468908_ENST00000452740_32881886_33245048 length=1339nt 
 Breakpoint=0nt
TGGTTGAAGGCCTTTCACTGTTGGACTTGGGAGTATCTCCGTATTCTGGAGCAGTATTTCATGAAACTCCATTAATAATATACCTCTTTCATTTCCTAATTGACTATGCTGAATTGGTGTTTATGATAACTGATGCACTCACTGCTATTG
CCCTGTATTTTGCAATCCAGGACTTCAATAAAGTTGTGTTTAAAAAGCAGAAACTCCTCCTAGAACTGGACCAGTATGCCCCAGATGTGGCCGAACTCATCCGGACCCCTATGGAAATGCGTTACATCCCTTTGAAAGTGGCCCTGTTCT
ATCTCTTAAATCCTTACACGATTTTGTCTTGTGTTGCCAAGTCTACCTGTGCCATCAACAACACCCTCATTGCTTTCTTCATTTTGACTACGATAAAAGGCAGTGCTTTCCTCAGTGCTATTTTTCTTGCCTTAGCGACATACCAGTCTC
TGTACCCACTCACCTTGTTTGTCCCAGGACTCCTCTATCTCCTCCAGCGGCAGTACATACCTGTGAAAATGAAGAGCAAAGCCTTCTGGATCTTTTCTTGGGAGTATGCCATGATGTATGTGGGAAGCCTAGTGGTAATCATTTGCCTCT
CCTTCTTCCTTCTCAGCTCTTGGGATTTCATCCCCGCAGTCTATGGCTTTATACTTTCTGTTCCAGATCTCACTCCAAACATTGGTCTTTTCTGGTACTTCTTTGCAGAGATGTTTGAGCACTTCAGCCTCTTCTTTGTATGTGTGTTTC
AGATCAACGTCTTCTTCTACACCATCCCCTTAGCCATAAAGCTAAAGGAGCACCCCATCTTCTTCATGTTTATCCAGATCGCTGTCATCGCCATCTTTAAGTCCTACCCGACAGTGGGGGACGTGGCGCTCTACATGGCCTTCTTCCCCG
TGTGGAACCATCTCTACAGATTCCTGAGAAACATCTTTGTCCTCACCTGCATCATCATCGTCTGTTCCCTGCTCTTCCCTGTCCTGTGGCACCTCTGGATTTATGCAGGAAGTGCCAACTCTAATTTCTTTTATGCCATCACACTGACCT
TCAACGTTGGGCAGATGGGCTTCTGTGGTGATAGAATGGCAGGTACTTGTCCTGAGGCCATCAGAGCTGCTGGTGACAGGACACCTTCCTGAACTCCTCCAGGCGCCTCTGATCTCTCCTTAGCTGCTGTTGTGTTACCTTCAGATCCTG
CTCATCTCTGATTACTTCTATGCCTTCCTGCGGCGGGAGTACTACCTCACACATGGCCTCTACTTGACCGCCAAGGATGGCACAGAGGCCATGCTCGTGCTCAAGTAGGCCTGGCTGGCACAGGGCTGCATGGACCTCA

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for AHCY_PIGU

In-frame Fusion Protein Sequences.

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048 length=497nt
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000538132_ENST00000452740_32881886_33245048 length=998nt
MAAERRCGSMRDLRAQVTSGLLPFPEVTLQALGEDEITLESVLRGKFAAGKNGLACLACGPQLEVVNSITGERLSAYRFSGVNEQPPVVLAVKEFSWQKRTGLLIGLEETEGSVLCLYDLGISKVVKAVVLPGRVTAIEPIINHGGASAS
TQHLHPSLRWLFGVAAVVTDVGQILLVDLCLDDLSCNQNEVEASGLLMSALTVFILILYFVIDNFVINRRPWLPECTPIYIQYFVKFFIIGITVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTM
NRMTVVQAYIGGIHYRQIPSPDVFLPKVLDLIVNGISINSAYTSKILPPEKEGGLPRQVGNKTECALLGFVTDLKQDYQAVRNEVPEEKLYKVYTFNSVRKSMSTVIRNPNGGFRMYSKGASEIILRKCNRILDRKGEAVPFKNKDRDDM
VRTVIEPMACDGLRTICIAYRDFDDTEPSWDNENEILTELTCIAVVGIEDPVRPEVPDAIAKCKQAGITVRMVTGDNINTARAIATKCGILTPGDDFLCLEGKEFNRLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTLVKGIIDST
VGEHRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLKRRPYGRNKPLISRTMMKNILG
HAFYQLIVIFILVFAGEKFFDIDSGRKAPLHSPPSQHYTIVFNTFVLMQLFNEINSRKIHGEKNVFSGIYRNIIFCSVVLGTFICQIFIVEFGGKPFSCTSLSLSQWLWCLFIGIGELLWGQFISAIPTRSLKFLKEAGHGTTKEEITKD
AEGLDEIDHAEMELRRGQILWFRGLNRIQTQIDVINTFQTGASFKGVLRRQNMGQHLDVKLVPSSSYVAVAPVKSSPTTSVPAVSSPPMGNQSGQSVP

N-Truncated Protein (5UTR-3CDS) Sequences

>AHCY_PIGU_ENST00000468908_ENST00000374820_32881886_33245048 length=590nt
MEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVEGYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKI
IEEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIA
KLVVWAADRQAALTKLRYSLRQYNIVGLHTNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSSSSGRRLNISYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQV
LGNLYSEGDCTYLKCSVNGVASKAKLIILENTIYLFSKEGSIEIDIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVFYREGAQANRHTPLVEFEEEESDKRESE

>AHCY_PIGU_ENST00000468908_ENST00000452740_32881886_33245048 length=366nt
MLDLGVSPYSGAVFHEITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKS
KAFWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLF
PVLWHLWIYAGSANSNFFYAITLTFNVGQILLISDYFYAFLRREYYLTHGLYLTAKDGTEAMLVLK

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for AHCY_PIGU

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.I99M_497_I173M length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAMQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_5-gene_p.A93S_497_A112S length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAISKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_5-gene_p.P98T_497_P117T length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGITVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.I86V_497_I160V length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMVTDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.A389V_497_A463V length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYVITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.V335M_497_V409M length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDMALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.I390T_497_I464T length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYATTLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.V55L_497_V129L length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGLSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.V297I_497_V371I length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINIFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_5-gene_p.I81M_497_I100M length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNMFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.L145I;p.E280D_497_L219I;E354D length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYILNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFADMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_5-gene_p.V68I_497_V87I length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLITLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.F341L_497_F415L length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMALFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_5-gene_p.V68I_497_V87I length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLITLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.V55L_497_V129L length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGLSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_5-gene_p.V68I_497_V87I length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLITLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.A168T;p.P330L_497_A242T;P404L length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLITFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYLTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.C360Y_497_C434Y length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTYIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_5-gene_p.R34H_497_R53H length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMHMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_5-gene_p.L45R_497_L64R length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPRKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_5-gene_p.R19H;p.R38Q_497_R38H;R57Q length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGHKALDIAENEMPGLMRMREQYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.F288L_497_F362L length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLLFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.A324T_497_A398T length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVITIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_5-gene_p.R49H_497_R68H length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGAHIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.L90V_497_L164V length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDAVTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_5-gene_p.A72T_497_A91T length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGTEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.F386L_497_F460L length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNLFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.A92V_497_A166V length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTVIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.L76I_497_L150I length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFI
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_5-gene_p.W76L_497_W95L length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQLSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_5-gene_p.R36W_497_R55W length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMWERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.Y378H_497_Y452H length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IHAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.E310K_497_E384K length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKKHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_5-gene_p.T69A_497_T88A length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.W251C_497_W325C length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSCDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.I377M_497_I451M length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
MYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.F277L_497_F351L length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYLFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.S219N_497_S293N length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKNKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.G177C_497_G251C length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKCSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.P148S_497_P222S length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNSYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_5-gene_p.P30L_497_P49L length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMLGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.H74Y_497_H148Y length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFYFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.E81K_497_E155K length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAKLVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.V344M_497_V418M length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPMWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.A305G_497_A379G length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLGIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.F260L_497_F334L length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGLILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_both_p.R34H-p.S366P_497_R53H;S440P length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMHMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCPLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.F185L_497_F259L length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAILLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.L248V_497_L322V length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLVSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.P57Q_497_P131Q length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSQYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.I271N_497_I345N length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNNGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.F170L_497_F244L length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFLILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.P57L_497_P131L length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSLYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.T91I_497_T165I length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALIAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_5-gene_p.V68I_497_V87I length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLITLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_5-gene_p.L32M_497_L51M length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGMMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.Q294E_497_Q368E length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFEINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.F314L_497_F388L length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPILFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.P148A_497_P222A length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNAYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.A189V_497_A263V length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALVTYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.S384F_497_S458F length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANFNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.F274L_497_F348L length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLLWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

>AHCY_PIGU_ENST00000217426_ENST00000374820_32881886_33245048_3-gene_p.C360W_497_C434W length=497AA
MCALRPLSAPSPPLRAQDLIVCKSKHGKADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFL
IDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFS
WEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTWIIIVCSLLFPVLWHLW
IYAGSANSNFFYAITLTFNVGQMGFCGDRMAGTCPEAIRAAGDRTPS

Fusion Protein ID	Sample ID	Mutated Partner	AAchange in WT	Seq. Length	AAchange in Fusion
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-24-2295-01A	3-gene	p.I99M	497	I173M
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-49-AAR9-01A	5-gene	p.A93S	497	A112S
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-66-2754-01A	5-gene	p.P98T	497	P117T
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-97-8174-01A	3-gene	p.I86V	497	I160V
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-A5-A1OF-01A	3-gene	p.A389V	497	A463V
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-A6-2686-01A	3-gene	p.V335M	497	V409M
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-A6-5661-01A	3-gene	p.I390T	497	I464T
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-AB-2826-03B	3-gene	p.V55L	497	V129L
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-AG-A036-01A	3-gene	p.V297I	497	V371I
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-AR-A2LE-01A	5-gene	p.I81M	497	I100M
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-AX-A2HC-01A	3-gene	p.L145I;p.E280D	497	L219I;E354D
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-AX-A2HD-01A	5-gene	p.V68I	497	V87I
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-AZ-4315-01A	3-gene	p.F341L	497	F415L
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-AZ-6601-01A	5-gene	p.V68I	497	V87I
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-B0-5075-01A	3-gene	p.V55L	497	V129L
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-B5-A0JR-01A	5-gene	p.V68I	497	V87I
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-B5-A3FA-01A	3-gene	p.A168T;p.P330L	497	A242T;P404L
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-B9-5155-01A	3-gene	p.C360Y	497	C434Y
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-BK-A13B-01A	5-gene	p.R34H	497	R53H
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-BR-6566-01A	5-gene	p.L45R	497	L64R
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-BR-7851-01A	5-gene	p.R19H;p.R38Q	497	R38H;R57Q
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-BS-A0UF-01A	3-gene	p.F288L	497	F362L
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-CK-4951-01A	3-gene	p.A324T	497	A398T
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-CM-4746-01A	5-gene	p.R49H	497	R68H
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-CQ-7072-01A	3-gene	p.L90V	497	L164V
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-D1-A177-01A	5-gene	p.A72T	497	A91T
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-D1-A17Q-01A	3-gene	p.F386L	497	F460L
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-D1-A2G5-01A	3-gene	p.A92V	497	A166V
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-D3-A2J6-06A	3-gene	p.L76I	497	L150I
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-D3-A2JC-06A	5-gene	p.W76L	497	W95L
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-D5-6928-01A	5-gene	p.R36W	497	R55W
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-DA-A1I7-06A	3-gene	p.Y378H	497	Y452H
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-DA-A1IC-06A	3-gene	p.E310K	497	E384K
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-DI-A1BU-01A	5-gene	p.T69A	497	T88A
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-DJ-A2QB-01A	3-gene	p.W251C	497	W325C
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-E6-A1LX-01A	3-gene	p.I377M	497	I451M
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-E6-A1M0-01A	3-gene	p.F277L	497	F351L
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-E6-A2P8-01A	3-gene	p.S219N	497	S293N
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-EE-A20F-06A	3-gene	p.G177C	497	G251C
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-EE-A29D-06A	3-gene	p.P148S	497	P222S
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-EE-A2GT-06A	5-gene	p.P30L	497	P49L
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-EE-A3J7-06A	3-gene	p.H74Y	497	H148Y
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-EK-A2R8-01A	3-gene	p.E81K	497	E155K
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-EK-A2RJ-01A	3-gene	p.V344M	497	V418M
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-ER-A195-06A	3-gene	p.A305G	497	A379G
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-EY-A1GI-01A	3-gene	p.F260L	497	F334L
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-FI-A2D5-01A	both	p.R34H-p.S366P	497	R53H;S440P
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-FR-A726-01A	3-gene	p.F185L	497	F259L
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-FS-A1ZG-06A	3-gene	p.L248V	497	L322V
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-FS-A1ZR-06A	3-gene	p.P57Q	497	P131Q
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-FW-A3TU-06A	3-gene	p.I271N	497	I345N
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-GD-A3OP-01A	3-gene	p.F170L	497	F244L
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-HF-7132-01A	3-gene	p.P57L	497	P131L
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-HR-A2OG-06A	3-gene	p.T91I	497	T165I
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-HU-A4GQ-01A	5-gene	p.V68I	497	V87I
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-IB-7651-01A	5-gene	p.L32M	497	L51M
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-LP-A4AV-01A	3-gene	p.Q294E	497	Q368E
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-OR-A5KB-01A	3-gene	p.F314L	497	F388L
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-R3-A69X-01A	3-gene	p.P148A	497	P222A
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-UY-A9PE-01A	3-gene	p.A189V	497	A263V
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-XF-A8HG-01A	3-gene	p.S384F	497	S458F
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-ZF-AA4N-01A	3-gene	p.F274L	497	F348L
ENST00000217426_ENST00000374820_32881886_33245048	TCGA-ZS-A9CG-01A	3-gene	p.C360W	497	C434W

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for AHCY_PIGU

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		STAD	TCGA-HU-A4GX	AHCY	chr20	32881886	-	PIGU	chr20	33245048	-

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

dbVar

nstd239

Unknown_Cell

WG1004325-DNAB10-016925-0095480196

AHCY

chr20

32883308

PIGU

chr20

33238981

DEL

dbVar

nstd239

Unknown_Cell

WG1004325-DNAB10-016925-0095480196

AHCY

chr20

32890337

PIGU

chr20

33238981

DEL

dbVar

nstd239

Unknown_Cell

WG1004376-DNAH11-011435-0095500279

AHCY

chr20

32890337

PIGU

chr20

33238981

DEL

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Related Drugs for AHCY_PIGU

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status