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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:MICU2_ATP8A2 (FusionGDB2 ID:HG221154TG51761)

Fusion Gene Summary for MICU2_ATP8A2

Fusion gene summary

Fusion gene information	Fusion gene name: MICU2_ATP8A2
	Fusion gene ID: hg221154tg51761
		Hgene	Tgene
	Gene symbol	MICU2	ATP8A2
	Gene ID	221154	51761
	Gene name	mitochondrial calcium uptake 2	ATPase phospholipid transporting 8A2
	Synonyms	1110008L20Rik\|EFHA1	ATP\|ATPIB\|CAMRQ4\|IB\|ML-1
	Cytomap	13q12.11	13q12.13
	Type of gene	protein-coding	protein-coding
	Description	calcium uptake protein 2, mitochondrialEF hand domain family A1EF hand domain family, member A1EF-hand domain-containing family member A1Smhs2 homolog	phospholipid-transporting ATPase IBATPase, aminophospholipid transporter, class I, type 8A, member 2ATPase, aminophospholipid transporter-like, class I, type 8A, member 2P4-ATPase flippase complex alpha subunit ATP8A2probable phospholipid-transporting
	Modification date	20240305	20240403
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000382374, ENST00000479790,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 7 X 8 X 6=336	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 7 X 16 X 13=1456
	# samples	9	22
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(9/33610)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(22/145610)=-2.72643492667404 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MICU2 [Title/Abstract] AND ATP8A2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MICU2(22178077)-ATP8A2(26402255), # samples:1

Fusion gene breakpoints across MICU2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ATP8A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for MICU2_ATP8A2

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
EFHA1	chr13	22178077	ATP8A2	chr13	26402255
EFHA1	chr13	22178078	ATP8A2	chr13	26402256
MICU2	chr13	22178077	ATP8A2	chr13	22178077
MICU2	chr13	22178078	ATP8A2	chr13	26402256
MICU2	chr13	21603939	ATP8A2	chr13	25828118

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for MICU2_ATP8A2

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
MICU2-ATP8A2	Promoter / Enhancer Hijacking M6		Promoter swap alters MICU2 mitochondrial calcium uptake regulator alongside ATP8A2 aminophospholipid flippase, modifying mitochondrial calcium buffering and membrane traffic.		Phosphatidylserine-targeting antibodies; mitochondrial modulators		Solid tumors

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
MICU2-ATP8A2	Promoter / Enhancer Hijacking M6		Promoter swap alters MICU2 mitochondrial calcium uptake regulator alongside ATP8A2 aminophospholipid flippase, modifying mitochondrial calcium buffering and membrane traffic.		Phosphatidylserine-targeting antibodies; mitochondrial modulators		Solid tumors	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 33649193; Title: Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MICU2	GO:0006851	mitochondrial calcium ion transmembrane transport	24560927
Hgene	MICU2	GO:0036444	calcium import into the mitochondrion	32494073
Hgene	MICU2	GO:0051560	mitochondrial calcium ion homeostasis	32494073
Hgene	MICU2	GO:0051562	negative regulation of mitochondrial calcium ion concentration	24560927

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Fusion Genomic Features for MICU2_ATP8A2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
MICU2	chr13	22178077	-	ATP8A2	chr13	26402255	+	4.86e-05	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for MICU2_ATP8A2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000382374	ENST00000491840	MICU2	chr13	22178077	-	ATP8A2	chr13	26402255	+
In-frame	ENST00000382374	ENST00000381655	MICU2	chr13	22178077	-	ATP8A2	chr13	26402255	+

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000382374	ENST00000381655	MICU2	chr13	22178077	ATP8A2	chr13	26402255	276	375

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000382374	ENST00000381655	MICU2	chr13	22178077	ATP8A2	chr13	26402255	1.55e-02	9.84e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000382374	ENST00000491840	MICU2	chr13	22178077	ATP8A2	chr13	26402255	0.00e+00	1.61e-01

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Fusion Protein Retained/Non-Retained Functional Features for MICU2_ATP8A2

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

MICU2_ATP8A2_chr13-22178077_chr13-26402255.png

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

1163_1182

893.0

1189.0

Compositional bias

Basic and acidic residues

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

1162_1188

893.0

1189.0

Region

Disordered

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

1019_1028

893.0

1189.0

Topological domain

Cytoplasmic

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

1050_1063

893.0

1189.0

Topological domain

Extracellular

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

1085_1188

893.0

1189.0

Topological domain

Cytoplasmic

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

909_910

893.0

1189.0

Topological domain

Extracellular

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

932_959

893.0

1189.0

Topological domain

Cytoplasmic

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

981_997

893.0

1189.0

Topological domain

Extracellular

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

1029_1049

893.0

1189.0

Transmembrane

Helical

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

1064_1084

893.0

1189.0

Transmembrane

Helical

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

911_931

893.0

1189.0

Transmembrane

Helical

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

960_980

893.0

1189.0

Transmembrane

Helical

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

998_1018

893.0

1189.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MICU2

chr13:22178077

chr13:26402255

ENST00000382374

Q8IYU8

172_207

70.0

435.0

Domain

EF-hand 1

Hgene

MICU2

chr13:22178077

chr13:26402255

ENST00000382374

Q8IYU8

227_262

70.0

435.0

Domain

EF-hand 2%3B degenerate

Hgene

MICU2

chr13:22178077

chr13:26402255

ENST00000382374

Q8IYU8

293_328

70.0

435.0

Domain

EF-hand 3%3B degenerate

Hgene

MICU2

chr13:22178077

chr13:26402255

ENST00000382374

Q8IYU8

362_397

70.0

435.0

Domain

EF-hand 4

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

116_119

893.0

1189.0

Topological domain

Extracellular

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

141_316

893.0

1189.0

Topological domain

Cytoplasmic

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

1_94

893.0

1189.0

Topological domain

Cytoplasmic

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

338_364

893.0

1189.0

Topological domain

Extracellular

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

386_887

893.0

1189.0

Topological domain

Cytoplasmic

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

120_140

893.0

1189.0

Transmembrane

Helical

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

317_337

893.0

1189.0

Transmembrane

Helical

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

365_385

893.0

1189.0

Transmembrane

Helical

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

888_908

893.0

1189.0

Transmembrane

Helical

Tgene

ATP8A2

chr13:22178077

chr13:26402255

ENST00000381655

Q9NTI2

95_115

893.0

1189.0

Transmembrane

Helical

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for MICU2_ATP8A2

In-frame Fusion Transcript Sequences.

>MICU2_ATP8A2_ENST00000382374_ENST00000381655_22178077_26402255 length=7030nt 
 Breakpoint=276nt
GAGAGTTCCCAAGCGGTAGGCGGCGGCGCCGGGAGAGAAGCGCCGCCTAGCTGCGCTTCCGCAAAGATGGCGGCGGCTGCGGGTAGCTGCGCGCGGGTGGCGGCCTGGGGCGGAAAACTGCGACGGGGGCTCGCTGTCAGCCGACAGGCT
GTGCGGAGTCCCGGCCCCTTGGCAGCGGCAGTGGCCGGCGCGGCCCTGGCAGGAGCAGGAGCGGCCTGGCACCACAGCCGCGTCAGTGTTGCGGCGCGGGATGGCAGTTTTACAGTCTCCGCACAGCTTTGGTTCGCCTTTGTTAATGGA
TTTTCTGGGCAGATTTTATTTGAACGTTGGTGCATCGGCCTGTACAATGTGATTTTCACCGCTTTGCCGCCCTTCACTCTGGGAATCTTTGAGAGGTCTTGCACTCAGGAGAGCATGCTCAGGTTTCCCCAGCTCTACAAAATCACCCAG
AATGGCGAAGGCTTCAACACAAAGGTTTTCTGGGGTCACTGCATCAACGCCTTGGTCCACTCCCTCATCCTCTTCTGGTTTCCCATGAAAGCTCTGGAGCATGATACTGTGTTGACAAGTGGTCATGCTACCGACTATTTATTTGTTGGA
AATATTGTTTACACATATGTTGTTGTTACTGTTTGTCTGAAAGCTGGTTTGGAGACCACAGCTTGGACTAAATTCAGTCATCTGGCTGTCTGGGGAAGCATGCTGACCTGGCTGGTGTTTTTTGGCATCTACTCGACCATCTGGCCCACC
ATTCCCATTGCTCCAGATATGAGAGGACAGGCAACTATGGTCCTGAGCTCCGCACACTTCTGGTTGGGATTATTTCTGGTTCCTACTGCCTGTTTGATTGAAGATGTGGCATGGAGAGCAGCCAAGCACACCTGCAAAAAGACATTGCTG
GAGGAGGTGCAGGAGCTGGAAACCAAGTCTCGAGTCCTGGGAAAAGCGGTGCTGCGGGATAGCAATGGAAAGAGGCTGAACGAGCGCGACCGCCTGATCAAGAGGCTGGGCCGGAAGACGCCCCCGACGCTGTTCCGGGGCAGCTCCCTG
CAGCAGGGCGTCCCGCATGGGTATGCTTTTTCTCAAGAAGAACACGGAGCTGTTAGTCAGGAAGAAGTCATCCGTGCTTATGACACCACCAAAAAGAAATCCAGGAAGAAATAAGACATGAATTTTCCTGACTGATCTTAGGAAAGAGAT
TCAGTTTGTTGCACCCAGTGTTAACACATCTTTGTCAGAGAAGACTGGCGTCAGCAGCCAAAACACCAGGAAACACATTTCTGTGGCCTTAGCCAAGCAGTTTGTTAGTTACATATTCCCTCGCAAACCTGGAGTGCAGACCACAGGGGA
AGCTATCTTTGCCCTCCCAACTCGTCTGCAGTGCTTAGCCTAACTTTTGTTTATGTCGTTATGAAGCATTCAACTGTGCTCTGTGAGGTGTGAAATTAAAAACATTATGTTTCACCAATATTTAAACATCAGTACTAGTTGTCCTGGGAG
AAAGGGAAAGGAGTTTTATGTTGCGTGAGAGGCCCATCCTGTGTAATTGGAGCAGGGCACACTTGCTTCCTGTTGAGTTAACTCAGAGGTTAAGTCCAACGGGCCACATGCAGACTTCACTGTAGGCAGGTTGCTCTCCTGCTTTGATTC
CTGTTTTGTGTGTAAAATTGGCATAAACTTCTTGATTGCAGTGAAATCACAAAATTCTCTATCGGGGTGGTCAACCTGAGAACATTTATTTGAACCTCTTAGCCACATTTCCAGCAGGGCAAACCAACTGATGCCCTGGAAGAGTCTTCC
GCACCCTCTCCAGGTGCACTCGGCCCAGTCCTGCCGCCGTGTCCAGGCGCCCCTCACCCCCACACCTGCTGCATGGCTGGCCACACCACTCAGTGCATGGCGGCCGATGGGCAGCCAACCCAAACCCGCGCCTTTCCTTGTTCCACTGCA
GACTCAGATACAGATGCGAAAAATTCCTTCTTCCACCGCCCTTCTCGTTCTGTAAAGAAAGAAAAGAAACATAGCCTTTCTGCATATATTCTAAACGTCTCTCTGCCTCTGTCTGACATGGGGCCACCCCACAGGTCAGAGTGGTGGTAG
AACCCCTTCAGGACTCCCAGCCGTGGTCAGGCTCTGAATACTCCCTTCCCAACATCCAGACTGCTGGGCCTTTGGCATCCACTTACATTAGAACCCACGTTTGTTTCAGAGCACATTTTGGACTTTCACTGTTGGGAAATGAATGAATTT
ATAACATGCCTGCACAGCGAAGGAACACACCTGTCGCTCTTAGCTCTAGAGTCAGAGGATGAGTAAACCCAGATGCAAGAGTATAGGACATTGAGTGGGGAGAACAAGACGACCACAGAAGTCCTCAGAAGGAGAAGGAAGGACACGGAG
ACACTGAGAGGAGGACACAGAGGAATCGCCACCAGATCTTTGCAGTAGAAACTCTGAAATAGGCCTTGAGACCCAGACAATTGTCATGATCAGCCCAGTGTGTATGAGAGCTTAAACAAGACCTTCACACACAGTTCTAATTGAAAAGAA
TTCCAAACATTTCAGGGAAACACCTTTTTAAAAAATATACTGACATGGTTTCCTTTCTGTATCCCATCAGTGTTAGACACAGGTACCTATCAGAATACGGCATATCCTGAATTATCTAAGACAAGGAAGTGAAGAGCGGAATCACTGACT
TTCCCAACTGCAGAGTCCCACACTTAAATCTCAACAGAACCTAGATGTCTTCAGGCATGAATGTGAGCACCTGGAGCCCTTACTAAACAACCTGCCTGGAGCCCTGTTCTCTGCTCTGGTTGCCAAACCAGATTTTTGGATGGCCTAAAT
ACTTGTGGGCAACTGTTACTGGTGAAAAATGGGAGTGGAGAGCATGTTTTGGATTTTCACTGTGGGGAAATGAATGAATTTATCACATGACTGTGCAGCGAAGGAGCACACCTGTCACTCTTAGCTCTAGAGTCGGAGGATGAGTCAACC
CTGTAGGAATGATTGTGCTAAATTAGGAAATAACACTTTAGTGCACTTTGCTTCCTAACCCTTTTTTGTCAGAAATCTACAACCTACTGGGCATGGAAATGATTTAAAATATGATCTGCATTGACTAAGAAAACTCATCCTCACTTATGA
GGTGACCAGGATGCAGAGAGGGCCTGAGGGGCAGCAGAACAATGCAATTCACAGGTGAGGCTCCAAAAAGGGCCATTTCTTTCTCCCCAAGGTGCATAGAACATTTTTAAATATCAGAGTACCCAGCAAGACGGAAGGACTGTCATGCAG
GAACTCTAACACAAAATGTGCCTATGACTAACACGACAAACCAAGGTGTATGGTTTCTTTGCACACCCAGAAAGGTGATGGCCAAGATACAGAGGAGAAACGAAAACTGGAATTGAATGTGCATTAGGCATCTTAACTATTCATATTTTG
TCTCATTTGGGAACTAAGCCTATTTGGAAAGAGTGGATTAGAAATTGAATTCTTTGTCAAACAGTTAGCTCTGTCTTGAACTTGAAGCCTTCCAAATCAGAATTATGTATTTAAGTGTGTGTTTGTGTTTGTTTGGGGTTTTTGTTTCTT
ACATTAGAGTTCATATTTTCTGGGATTTAAGGATACAGGTGTATTTTCCTATTCTCTTGAGAAGTAGACTAAACAATATTTGCAGTGATGACAGACGCACACAGAAGAAAACATTAGAAGAGATGCCTTTCTATCCTCTCATGTGGTTGA
GCATTCTTACAGCCAAATGACTAAATTGGCTGTAAATTGGTTTCTAGGAGGAGCAGCTGTCACTACGTGTGATGTATAATATTTAGCCAGGGCCAACTCAGGGGCTGTGTCATTTGTCCTATCTTTAAATTGAGGTCAGAGTGTCACACA
CAACCCCTCCCCTGGGGCAGGGTGGACTGGACTAGGTTGCATACGCTGGCTGTCAGCTCAGCAAAAATGCCACATGGGGCTTGTCACTCCGCCAGACACTCACTGACTCACGGGCTGGCAGGTCACGCTCGGTTAGCGCTCCAGGGCCTG
ACTCTGGATTGAGCTAAACTGGCAGAATCCACTCAGGCCAACCCTTGGTCTACTGCTGTGTACAGACAGCCCAGTCCTGTGTTGAGTCTCTCTTCTCCTGGATGACCCTGCAAAAGGAAGAGACCAGTTGTACTGTGGGCTTAGTTCTGG
GTTTCCACTGCACACTGACACGTGCCAGCAAGGGTAGCTGTGGAAAACACGTATCAGGAGAGCAGAGTAGTCTGGATGAATACTCTGTGCTGATCAGAACGGGCTCGGTCATAATTTAGGAGTGGAGCTGATGTGTCTGTCCTGCCTCAG
TGCAGAATATTCCAGGCTTCTTGACCAGGGTTATGTTCACCCATCTCCCAACACACACATGCACACATGAAAACAAAAACATGGTAACTCTTTTGGTTCGGCACACCATACAAAACGTGCTTTGGGGCGAGGAGTGCTGTTTCTTTTAAC
ACTTGTAGAGGAATATCCTGAGAAGTGAACCTGGGCTTTGGGAGAGCTCAGCTGAGAATTCTGTTGACATTTTCTTTCCCTTGACAAGGCTTCAGGTTCGTCTCACTATAGGGAGCTGGCTGTGAAAATCAGTAATAACTTGTCAAGAAG
CAGTGAAAAATGCGGGGGGGTGGAAAGAGCCTAGGTAACTAATGTCTTATAATGCATATGTATGTAAATATTACAGGATTTAAGGTTGAATTTTTTAAAAAGAAAGTTATAGTCTGTAATTTCCATTTGTTATAATAATGACCTTTAATC
TTGTCATTTGGAACCATAAAGCATTTTTATCAGGTACCTCTGTTCCAAGGGATTTATGTCTTAGACCATAGCTGAATTGAATGTTTGCAAAACACTGCTATAGGATAAGGTGGTCTTTAGTTTTGAACGTGTGAAAGGACTGCACACTTT
TCAGCCAGGGTTTGAGTTACTGCCCAGGGTCATCGTCTCAAAGTAATTCAAGGAGTGATTTAACATCAGCATTTGAAATGTAGTCTTCATCTCCTGGGATCCATAAAAAAATGTGAACAGGGAAATGGTGGCTAAGCAGAGCCTGAAATA
ATAACTTGGCAAAGAAATGAGTTTATCAGGTCGAGTCAAAACATGGCATCCCCTGTTACACTCAAGAAATGTTTTCTTCATGTAAATGTTTATACGGGCATATATAATCACAATGGGAACAGTTAAAACCCCCTCCCTTCAAAAAAAGAA
AATCTATATCAGTTGGGTTTGGTTTTGGTTCTTCATTGGCTCAAGGCAGTTAACTGTCTCAGTATAGCCTTCGGGGAGATTTAACCTCATTCTAGCCATTTTTCCATCCTGAAGGCCAAGAAGGACTATTAGAAGGGTTTTTGAGGGGTT
TCGGAGGTGAGGGCCCAAGACCCCCATAATGACATCATTAGGCATTCTTGAAAGGTGTTAACAGACCAGCACGCTCGATGTGTTGTACCCTTCATTTATTTTTTTTTCTCAGCATCCCAAGTTGTCCATCAGTACATTCCCCTTCACCTT
ACCTGATCTTCATTTAATGCCCAGTCTGTAACTAATGTTCTGTTTAAAGCTCTCTTAATTTGTTGGCTATGAGTGATTTGTGAATCTGGGATGTAACCCTGAGTGAGGAGAAAAGGGCATTGAGCCAGCATAAATCTGAATGGGCAGAAG
CCACAAACAAATGGGAGCAGAAAAGAAGGGCGAGCTCCCCCGCGCCGCACCCCGTGTATAATCCAGTGTTAACCTCTGAGGAACACCTCGGCTCTCCCAACTGAGGAGAGACAAAAGAGGGATTCTTTTTACACCCAGGCTGGCGCATTT
TCAAGTGACAATCTCGGGCTCTAGTTGCCTTTGAGATATCCACTCTGCTCTTTCTCCCAGGCCTCAGACCAAGAAAAACATGCTCTCAAGATTAGCCCATAGGCAGTTCTTGTGACCTGGCTGAAGAAAGAAAGGAGACCTGTTTGTTTT
AAAAGTCGGGCGCAAAGTGTCAGGTGGCTTTGATTTATGACAGAAAGAGGAAGAAGAAAGTTGGAGTAATAGCACTATCCAAATAACCCTGCCCAGGAAACTTGGGGGTCAAGAGAGCTTATCAAGAGCCTTTTATAGGTAAGCTCTTCC
GTGTGAAAGAGAAAAGGCCGGAAAGAGGGAGAGAGCCCAGAGAGCAGGCTGCGAACTCACTTCCAATGGGATTGGAGTCTGTTGTATTCTTAAGAGATAGCCTGATATGTGGTTTATAGGTGAATCAATAAACACCAACAACAACAAAAA
AAAAAAAAAAAAAAAAGGAAGAAAAGAAAAAAAGGAAACCAGCCCTGTCATGGAATTTCTCTCCTTCCCTGCACAGTAAAGACTTTTGGGTTTTCATGGATAAAATCAATGTCAGTACTGAAACTCCTACTCTCCCCTCCCGCCCCACTC
TCCCCCGTTGCCCGAGATGGCCAAGTTCAGGCCTGTGCAATGCCGCTTCCCTCTGAGCCTCCCTCTCAAGGGCCACGCAGGCAGCTGCAGCAGGGCCAGCTGCAGGATGGGGCTGCCGGTCACTGAATTGTCGTTCAAATGCATCATCTT
TGTGGCGTCTTTCTCATGCGAGCAAAGCCACGTGCTCTCCTGTCTGCTGTCACATCTGTGCCTGGATTGCTTAAATATTGTTTGTGATGGGGAGGTTTTAATCTGGTGATGCAGAGGGAAGCAGGGCTGTGGGGGCACGTTTAATTGGCT
CCCAGCAGCGTGGGGGGTGCTTCTATGGTGTGTGGGGTTTTTTGTTGCCTCCCTCTAGAAGTGTTACCGTTTTCACGTCCTATTAATGTCCTCTGGTTGTTAAATTACAGCAGCACATTACAGTGCACTGGGTTCCCTCCTGGAGTGAAT
ACAAACGGAGGGCATCTACTTGTATTTTTAGAAGTTTTGGGAGAATTTAGTGATTTGTGGCTTTGATCAATCCTGTTGACTGGTGTATGTCTGCGCAAACCTGTTTCAAATAAATCTTTTGTTAAAGTAA

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

>MICU2_ATP8A2_ENST00000382374_ENST00000491840_22178077_26402255 length=276nt 
 Breakpoint=276nt
GAGAGTTCCCAAGCGGTAGGCGGCGGCGCCGGGAGAGAAGCGCCGCCTAGCTGCGCTTCCGCAAAGATGGCGGCGGCTGCGGGTAGCTGCGCGCGGGTGGCGGCCTGGGGCGGAAAACTGCGACGGGGGCTCGCTGTCAGCCGACAGGCT
GTGCGGAGTCCCGGCCCCTTGGCAGCGGCAGTGGCCGGCGCGGCCCTGGCAGGAGCAGGAGCGGCCTGGCACCACAGCCGCGTCAGTGTTGCGGCGCGGGATGGCAGTTTTACAGTCTCCGCACAG

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Fusion Protein Sequence for MICU2_ATP8A2

In-frame Fusion Protein Sequences.

>MICU2_ATP8A2_ENST00000382374_ENST00000381655_22178077_26402255 length=375nt
MVSLKAKLNHLRQSMLKQKAPQRNFEIAFKMFDLNGDGEVDMEEFEQVQSIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLELIGALVLSVGIYAEVERQKYKTLESAFLAPAIILILL
GVVMFMVSFIGVLASLRDNLYLLQAFMYILGICLIMELIGGVVALTFRNQTIDFLNDNIRRGIENYYDDLDFKNIMDFVQKKFKCCGGEDYRDWSKNQYHDCSAPGPLACGVPYTCCIRNTTEVVNTMCGYKTIDKERFSVQDVIYVRGC
TNAVIIWFMDNYTIMAGILLGILLPQFLGVLLTLLYITRVEDIIMEHSVTDGLLGPGAKPSVEAAGTGCCLCYPN

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for MICU2_ATP8A2

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for MICU2_ATP8A2

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		BRCA	TCGA-E9-A22D-01A	EFHA1	chr13	22178077	-	ATP8A2	chr13	26402255	+
ChimerDB		BRCA	TCGA-E9-A22D-01A	EFHA1	chr13	22178078	-	ATP8A2	chr13	26402256	+
ChimerDB		BRCA	TCGA-E9-A22D	EFHA1	chr13	22178077	-	ATP8A2	chr13	26402255	+
TCGAfusionPortal		BRCA	TCGA-E9-A22D-01A	EFHA1	chr13	22178077	-	ATP8A2	chr13	26402255	+
ChimerDB		BRCA	TCGA-E9-A22D-01A	MICU2	chr13	22178077	-	ATP8A2	chr13	22178077	+
WashU		BRCA	TCGA-E9-A22D-01A	MICU2	chr13	22178078	-	ATP8A2	chr13	26402256	+
cBioPortal	BRCA_TCGA_PAN_CAN_ATLAS_2018	BRCA	TCGA-E9-A22D-01	MICU2	chr13	21603939		ATP8A2	chr13	25828118

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for MICU2_ATP8A2

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status