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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:FGF12_LRRC15 (FusionGDB2 ID:HG2257TG131578)

Fusion Gene Summary for FGF12_LRRC15

Fusion gene summary

Fusion gene information	Fusion gene name: FGF12_LRRC15
	Fusion gene ID: hg2257tg131578
		Hgene	Tgene
	Gene symbol	FGF12	LRRC15
	Gene ID	2257	131578
	Gene name	fibroblast growth factor 12	leucine rich repeat containing 15
	Synonyms	DEE47\|EIEE47\|FGF12B\|FHF1	LIB
	Cytomap	3q28-q29	3q29
	Type of gene	protein-coding	protein-coding
	Description	fibroblast growth factor 12fibroblast growth factor 12Bfibroblast growth factor FGF-12bfibroblast growth factor homologous factor 1myocyte-activating factor	leucine-rich repeat-containing protein 15hLibleucine-rich repeat protein induced by beta amyloidleucine-rich repeat protein induced by beta-amyloid homolog
	Modification date	20240305	20240317
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000264730, ENST00000430714, ENST00000445105, ENST00000450716, ENST00000466144, ENST00000454309,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 5 X 7 X 5=175	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 2 X 4 X 3=24
	# samples	11	5
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(11/17510)=-0.669851398307669 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(5/2410)=1.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: FGF12 [Title/Abstract] AND LRRC15 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FGF12(192444969)-LRRC15(194081775), # samples:1

Fusion gene breakpoints across FGF12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LRRC15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for FGF12_LRRC15

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
FGF12	chr3	192444969	LRRC15	chr3	194081775

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for FGF12_LRRC15

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	LRRC15	GO:0046597	negative regulation of viral entry into host cell	36228039\|36757924
Tgene	LRRC15	GO:0046813	receptor-mediated virion attachment to host cell	36228039\|36735681\|36757924

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Fusion Genomic Features for FGF12_LRRC15

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
FGF12	chr3	192444969	-	LRRC15	chr3	194081775	-	3.12e-04	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
FGF12	chr3	192444969	-	LRRC15	chr3	194081775	-	3.12e-04	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for FGF12_LRRC15

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000264730	ENST00000347624	FGF12	chr3	192444969	-	LRRC15	chr3	194081775	-
5CDS-5UTR	ENST00000264730	ENST00000428839	FGF12	chr3	192444969	-	LRRC15	chr3	194081775	-
5CDS-5UTR	ENST00000430714	ENST00000347624	FGF12	chr3	192444969	-	LRRC15	chr3	194081775	-
5CDS-5UTR	ENST00000430714	ENST00000428839	FGF12	chr3	192444969	-	LRRC15	chr3	194081775	-
5CDS-5UTR	ENST00000445105	ENST00000347624	FGF12	chr3	192444969	-	LRRC15	chr3	194081775	-
5CDS-5UTR	ENST00000445105	ENST00000428839	FGF12	chr3	192444969	-	LRRC15	chr3	194081775	-
5CDS-5UTR	ENST00000450716	ENST00000347624	FGF12	chr3	192444969	-	LRRC15	chr3	194081775	-
5CDS-5UTR	ENST00000450716	ENST00000428839	FGF12	chr3	192444969	-	LRRC15	chr3	194081775	-
5UTR-3CDS	ENST00000466144	ENST00000439944	FGF12	chr3	192444969	-	LRRC15	chr3	194081775	-
5UTR-5UTR	ENST00000466144	ENST00000347624	FGF12	chr3	192444969	-	LRRC15	chr3	194081775	-
5UTR-5UTR	ENST00000466144	ENST00000428839	FGF12	chr3	192444969	-	LRRC15	chr3	194081775	-
Frame-shift	ENST00000264730	ENST00000439944	FGF12	chr3	192444969	-	LRRC15	chr3	194081775	-
Frame-shift	ENST00000430714	ENST00000439944	FGF12	chr3	192444969	-	LRRC15	chr3	194081775	-
Frame-shift	ENST00000445105	ENST00000439944	FGF12	chr3	192444969	-	LRRC15	chr3	194081775	-
In-frame	ENST00000450716	ENST00000439944	FGF12	chr3	192444969	-	LRRC15	chr3	194081775	-

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000450716	ENST00000439944	FGF12	chr3	192444969	LRRC15	chr3	194081775	2.08e-03	9.98e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000466144	ENST00000439944	FGF12	chr3	192444969	LRRC15	chr3	194081775	0.00e+00	2.11e-03

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for FGF12_LRRC15

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

499_509

5.0

588.0

Compositional bias

Low complexity

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

22_53

5.0

588.0

Domain

Note=LRRNT

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

423_475

5.0

588.0

Domain

Note=LRRCT

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

489_509

5.0

588.0

Region

Disordered

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

102_123

5.0

588.0

Repeat

Note=LRR 3

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

126_147

5.0

588.0

Repeat

Note=LRR 4

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

150_171

5.0

588.0

Repeat

Note=LRR 5

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

174_195

5.0

588.0

Repeat

Note=LRR 6

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

198_219

5.0

588.0

Repeat

Note=LRR 7

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

222_243

5.0

588.0

Repeat

Note=LRR 8

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

246_267

5.0

588.0

Repeat

Note=LRR 9

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

270_291

5.0

588.0

Repeat

Note=LRR 10

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

294_315

5.0

588.0

Repeat

Note=LRR 11

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

318_339

5.0

588.0

Repeat

Note=LRR 12

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

342_363

5.0

588.0

Repeat

Note=LRR 13

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

366_387

5.0

588.0

Repeat

Note=LRR 14

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

390_411

5.0

588.0

Repeat

Note=LRR 15

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

54_75

5.0

588.0

Repeat

Note=LRR 1

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

78_99

5.0

588.0

Repeat

Note=LRR 2

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

22_538

5.0

588.0

Topological domain

Extracellular

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

560_581

5.0

588.0

Topological domain

Cytoplasmic

Tgene

LRRC15

chr3:192444969

chr3:194081775

ENST00000439944

Q8TF66

539_559

5.0

588.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FGF12

chr3:192444969

chr3:194081775

ENST00000450716

P61328

11_38

4.333333333333333

182.0

Motif

Bipartite nuclear localization signal

Hgene

FGF12

chr3:192444969

chr3:194081775

ENST00000450716

P61328

1_39

4.333333333333333

182.0

Region

Disordered

Hgene

FGF12

chr3:192444969

chr3:194081775

ENST00000450716

P61328

216_243

4.333333333333333

182.0

Region

Disordered

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for FGF12_LRRC15

In-frame Fusion Transcript Sequences.

>FGF12_LRRC15_ENST00000450716_ENST00000439944_192444969_194081775 length=6004nt 
 Breakpoint=204nt
TTAAAGCAGGAGCCTTGAGAGCCTGATAAGCTGTTGACACAAGTGCTTTTGAGAATAGCAGGAAGCCTGAGGGGAAGGAAGGAAGTACGGGCGAAATCATCAGATTGGCTTCCCAGATTTGGGAATCTGAAGCGGGCCCACATCTTCCGG
CCAACTTCCATTGAACTTCCCAGCACTCGAAAGGGACCGAAATGGAGAGCAAAGGCTATGCCACTGAAGCATTATCTCCTTTTGCTGGTGGGCTGCCAAGCCTGGGGTGCAGGGTTGGCCTACCATGGCTGCCCTAGCGAGTGTACCTGC
TCCAGGGCCTCCCAGGTGGAGTGCACCGGGGCACGCATTGTGGCAGTGCCCACCCCTCTGCCCTGGAACGCCATGAGCCTGCAGATCCTCAACACGCACATCACTGAACTCAATGAGTCCCCGTTCCTCAATATCTCAGCCCTCATCGCC
CTGAGGATTGAGAAGAATGAGCTGTCGCGCATCACGCCTGGGGCCTTCCGAAACCTGGGCTCGCTGCGCTATCTCAGCCTCGCCAACAACAAGCTGCAGGTTCTGCCCATCGGCCTCTTCCAGGGCCTGGACAGCCTCGAGTCTCTCCTT
CTGTCCAGTAACCAGCTGTTGCAGATCCAGCCGGCCCACTTCTCCCAGTGCAGCAACCTCAAGGAGCTGCAGTTGCACGGCAACCACCTGGAATACATCCCTGACGGAGCCTTCGACCACCTGGTAGGACTCACGAAGCTCAATCTGGGC
AAGAATAGCCTCACCCACATCTCACCCAGGGTCTTCCAGCACCTGGGCAACCTCCAGGTCCTCCGGCTGTATGAGAACAGGCTCACGGATATCCCCATGGGCACTTTTGATGGGCTTGTTAACCTGCAGGAACTGGCTCTGCAGCAGAAC
CAGATTGGACTGCTCTCCCCTGGTCTCTTCCACAACAACCACAACCTCCAGAGACTCTACCTGTCCAACAACCACATCTCCCAGCTGCCACCCAGCGTCTTCATGCAGCTGCCCCAGCTCAACCGTCTTACTCTCTTTGGGAATTCCCTG
AAGGAGCTCTCTCCGGGGATCTTCGGGCCCATGCCCAACCTGCGGGAGCTTTGGCTCTATGACAACCACATCTCTTCTCTACCCGACAATGTCTTCAGCAACCTCCGCCAGTTGCAGGTCCTGATTCTTAGCCGCAATCAGATCAGCTTC
ATCTCCCCGGGTGCCTTCAACGGGCTAACGGAGCTTCGGGAGCTGTCCCTCCACACCAACGCACTGCAGGACCTGGACGGGAACGTCTTCCGCATGTTGGCCAACCTGCAGAACATCTCCCTGCAGAACAACCGCCTCAGACAGCTCCCA
GGGAATATCTTCGCCAACGTCAATGGCCTCATGGCCATCCAGCTGCAGAACAACCAGCTGGAGAACTTGCCCCTCGGCATCTTCGATCACCTGGGGAAACTGTGTGAGCTGCGGCTGTATGACAATCCCTGGAGGTGTGACTCAGACATC
CTTCCGCTCCGCAACTGGCTCCTGCTCAACCAGCCTAGGTTAGGGACGGACACTGTACCTGTGTGTTTCAGCCCAGCCAATGTCCGAGGCCAGTCCCTCATTATCATCAATGTCAACGTTGCTGTTCCAAGCGTCCATGTCCCCGAGGTG
CCTAGTTACCCAGAAACACCATGGTACCCAGACACACCCAGTTACCCTGACACCACATCCGTCTCTTCTACCACTGAGCTAACCAGCCCTGTGGAAGACTACACTGATCTGACTACCATTCAGGTCACTGATGACCGCAGCGTTTGGGGC
ATGACCCAGGCCCAGAGCGGGCTGGCCATTGCCGCCATTGTAATTGGCATTGTCGCCCTGGCCTGCTCCCTGGCTGCCTGCGTCGGCTGTTGCTGCTGCAAGAAGAGGAGCCAAGCTGTCCTGATGCAGATGAAGGCACCCAATGAGTGT
TAAAGAGGCAGGCTGGAGCAGGGCTGGGGAATGATGGGACTGGAGGACCTGGGAATTTCATCTTTCTGCCTCCACCCCTGGGTCCATGGAGCTTTCCCGTGATTGCTCTTTCTGGCCCCAGAGAAAGGTGAGCCTACCTCTTCCTGACTT
GCCTGATTCTCCCGTAGAGAAGCAGGTCGTGCCGGACCTTCCTACAATCAGGAAGATAGATCCAACTGGCCATGGCAAAAGCCCTGGGGATTTCCGATTCATACCCCTGGGCTTCCTTCGAGAGGGCTCTTCCTCCAAATCCTCCCCACC
TGTCCTCCAAGAACAGCCTTCCCTGCGCCCAGGCCCCCTCCGGGCCTCTGTAGACTCAGTTAGTCCACAGCCTGCTCACTTCGTGGGAATAGTTCTCCGCTGAGATAGCCCCTCTCGCCTAAGTATTATGTAAGTTGATTTCCCTTCTTT
TGTTTCTCTTGTTTGTGCTACGGCTTGACCCAGCATGTCCCCTCAAATGAAAGTTCTCCCCTTGATTTTCTGCTCCTGAAGGCAGGGTGAGTTCTCTCCTCAAAGAAGACTTCAAACCATTTAACTGGTTTCTTAAGAGCCGTCAATCAG
CCTGGTTTTGGGGATGCTATGAAAGAGAGAAGGAAAATCATGCCGCTCAGTTCCTGGAGACAGAAGAGCCGTCATCAGTGTCTCACTTGTGATTTTTATCTGGAAAAGGAAGAAACACCCCAGCACAGCAAGCTCAGCCTTTTAGAGAAG
GATATTTCCAAACTGCAAACTTTGCTTTGAAAAGTTTAGCCCTTTAAGGAATGAAATCATGTAGAATTTTGGACTTCTAAAAACATTAAAATCAGCTTATTAATACGGGATAGAGAAAGAAATCTGGTGCCTGGGGGTCCCTGTGTTCAC
CCCTAGAGTTTGTTTTAAAATTTTTAATTGAAGCATGTGAAGTGTACGTGCAGAAAAGTGGGAACATGATAGTGTATGGCTTGGTGGATTTTCACAAACTGAACATACCTGTGTAATCAGCATCTAGACCCAGACCCAGAGCATCACAAA
TATCCCCCATCCTGGGCTTTTCCCAGAGGAGATGGGGGCTTCTGAAGATGGACTTACCTGGGACCTGCCCCCCATGAGCCAGGACGGTCCCCCCACAGTCAGCCTGTGCAAAGGCCCCGTGGCCAGGGGTGGAGGAGAATATGTGGGTGT
GGACAGGATGGGAGACTGTGGCCTGAACAGGAGATTTTATTATATCTGGAGACCCTGAGAGACCCTGAGACCTGGGGCACCATGGCTGGCCAGGTCAGAAGCATCCTGACTGCAGAGGTCCGTGCAGCCACACCCTCTTCCCTGCCAGCA
AGCTGTCTGCGGCTCATCGGAGGCCCCTCCGCCTGGAGCCTTCTATGGACGTGATATGCCTGTATCTGTTTTTAATTTTCATTCTTCACTTAGGGGAAGTGAAATCGCTCAGAGATGAGATCCTTTAATTGAAAACGAAGTGTAACGGAA
TCTAGTGTCTTTCTAATGTGGTAAAATTCTCCATCAACATCACAGTCAGCTGGCAGCTGAACTTCAGAATCTCACTTACAGCAGGCGACACGGGGGTACACCGATGGGTCACACTGGGTCTGGGGGCTCCCTGGAGCTCCTCCTGCGTGT
GGTCTGGTTAGGAGTTGAGTTGTTTGCTCCAGGGTTATTCTCCTCCTCGAGTCACAGTCACACGAATACCTGCCTTCTCTGGCTTTCCTGCTATACACATATTCACATGGCGCTCAAGAAGTTAGGCTCATGGCAACGTGTGTCTTTCTC
TGGACAACTGGCCCAGTTTACAGTGAAATGGAGAATTTCAGGTCTCCACGTCTGCCCAGGAAAGAACTTCAGCTGACTCCACGGGGATCTGGAAATCCACGACCAATCCCGATCGGCTCTTATTAGCTCCCCGCTCCACAAGACACCTGT
GCTTTGGAAATCCACCACCAATCCCGATCGGCTCTTATTAGCTCCCCGCTCCACAAGACACCTGTGATCTGGAAATCTACCACCAATCCCGATCGGCTCTTATTAGCTCCCCGCTCCACAAGACACCTGTGACATCCTCCAGGGCCACAG
GAGCACGTGCTGACCAGTTTTCCCTTCCAGTTCCTGCACAAAAAGTGTCCAGAGGGCTGTTTGCAAACACTAGTGCACTTTGTAGCTTTTCACCCTCTGTCCCAGGGAATCTAGGAGAGATGAGGCCCGTCAGAGTCAAGAGATGTCATC
CCCCCAGGGTCTCCAAGGCATTTCCACACTATTGGTGGCACCTGGAGGACATGCACCAAGGCTTGCCAGAGCCAACAGGAAGTGAGCCCAGAGCATGGCACATGAGCATCACCCGCTGATGGTGGCCTGCTGTGCCTGGTGCCAACAGGG
GCATCCCGGCCCGTACCCCTCCAGACAGGAAGCATGGGTTTGCCCACAGACCTGTCGGGTGCTCCTGTGAGTGGCCTCCAGATGTCTTTGTGCATAGGCACAAGTGGGCCAGGGCTGGAGGGAGGTGGGAAACCTCATCATCCGGTGGGC
CCTGCCAATCTTAACCCAGAACCCTTAGGTATTCCTGGCAGTAGCCATGACATTGGAGCACCTTCCTCTCCAGCCAGAGGCTGACCTGAGGGCCACTGTCCTCAGATGACACCACCCAGGAGCACCCTAGGTGAGGGGTGAGGGCCCCCT
TATGTGAACCTCTTGCCTCTTCCTTTCTCCCATCAGAGTGGTTGGATGGAGCCATTGGCCTCCTTTTCTTCAGCGGGCCCTTCAACCTCTCTGCACCATGTTGTCTGGCTGAGGAGCTACTAGAAAAGCTGAGTGGAGTCTCCTTTCCAA
CAGGATGATGCATTTGCTCAATTCTCAGGGCTGGAATGAGCCGGCTGGTCCCCCAGAAAGCTGGAGTGGGGTACAGAGTTCAGTTTTCCTCTCTGTTTACAGCTCCTTGACAGTCCCACGCCCATCTGGAGTGGGAGCTGGGAGTCAGTG
TTGGAGAAGAAACAACAAAAGCCAATTAGAACCACTATTTTTAAAAAGTGCTTACTGTGCACAGATACTCTTCAAGCACTGGACGTGGATTCTCTCTCTAGCCCTCAGCACCCCTGCGGTAGGAGTGCCGCCTCTACCCACTTGTGATGG
GGTACAGAGGCACTTGCTCTTCTGCATGGTGTTCAATAGGCTGGGAGTTTTATTTATCTCTTCAAACTTTGTACAAGAGCTCATGGCTTGTCTTGGGCTTTCGTCATTAAACCAAAGGAAATGGAAGCCATTCCCCTGTTGCTCTCCTTA
GTCTTGGTCATCAGAACCTCACTTGGTACCATATAGATCAAAAGCTTTGTAACCACAGGAAAAAATAAACTCTTCCATCCCTTAAAGAATAGAATAGTTTGTCCCTCTCATGGGAATTGGGCTGTATGTATATTGTTCTTCCTCCTTAGA
ATTTAGAGATACAAGAGTTCTACTTAGAACTTTTCATGGACACAATTTCCACAACCTTTCAGATGCTGATGTAGAGCTATTGGGAAAGAACTTCCAAACTCAGGAAGTTTGCAGAGAGCAGACAGCTAGAGATAACTCGGGACCCAGAGT
TGGTCGACAGATGTTAGATGTATCCTAGCTTTTAGCTATAAACCACTCAAAGATTCAGCCCCCAGATCCCACAGTCAGAACTGAATCTGCGTTGTTGGGAAGCCAGCAGTGGCCTTGGGAAGGAAGCCATGGCTGTGGTTCAGAGAGGGT
GGGCTGGCAAGCCACTTCCGGGGAAAACTCCTTCCGCCCCAGGTTTCTTCTTCTCTTAAGGAGAGATTGTTCTCACCAACCCGCTGCCTTCATGCTGCCTTCAAAGCTAGATCATGTTTGCCTTGCTTAGAGAATTACTGCAAATCAGCC
CCAGTGCTTGGCGATGCATTTACAGATTTCTAGGCCCTCAGGGTTTTGTAGAGTGTGAGCCCTGGTGGGCAGGGTTGGGGGGTCTGTCTTCTGCTGGATGCTGCTTGTAATCCATTTGGTGTACAGAATCAACAATAAATAATATACATG
TATA

N-Truncated Transcript (5UTR-3CDS) Sequences

>FGF12_LRRC15_ENST00000466144_ENST00000439944_192444969_194081775 length=5800nt 
 Breakpoint=0nt
GCTATGCCACTGAAGCATTATCTCCTTTTGCTGGTGGGCTGCCAAGCCTGGGGTGCAGGGTTGGCCTACCATGGCTGCCCTAGCGAGTGTACCTGCTCCAGGGCCTCCCAGGTGGAGTGCACCGGGGCACGCATTGTGGCAGTGCCCACC
CCTCTGCCCTGGAACGCCATGAGCCTGCAGATCCTCAACACGCACATCACTGAACTCAATGAGTCCCCGTTCCTCAATATCTCAGCCCTCATCGCCCTGAGGATTGAGAAGAATGAGCTGTCGCGCATCACGCCTGGGGCCTTCCGAAAC
CTGGGCTCGCTGCGCTATCTCAGCCTCGCCAACAACAAGCTGCAGGTTCTGCCCATCGGCCTCTTCCAGGGCCTGGACAGCCTCGAGTCTCTCCTTCTGTCCAGTAACCAGCTGTTGCAGATCCAGCCGGCCCACTTCTCCCAGTGCAGC
AACCTCAAGGAGCTGCAGTTGCACGGCAACCACCTGGAATACATCCCTGACGGAGCCTTCGACCACCTGGTAGGACTCACGAAGCTCAATCTGGGCAAGAATAGCCTCACCCACATCTCACCCAGGGTCTTCCAGCACCTGGGCAACCTC
CAGGTCCTCCGGCTGTATGAGAACAGGCTCACGGATATCCCCATGGGCACTTTTGATGGGCTTGTTAACCTGCAGGAACTGGCTCTGCAGCAGAACCAGATTGGACTGCTCTCCCCTGGTCTCTTCCACAACAACCACAACCTCCAGAGA
CTCTACCTGTCCAACAACCACATCTCCCAGCTGCCACCCAGCGTCTTCATGCAGCTGCCCCAGCTCAACCGTCTTACTCTCTTTGGGAATTCCCTGAAGGAGCTCTCTCCGGGGATCTTCGGGCCCATGCCCAACCTGCGGGAGCTTTGG
CTCTATGACAACCACATCTCTTCTCTACCCGACAATGTCTTCAGCAACCTCCGCCAGTTGCAGGTCCTGATTCTTAGCCGCAATCAGATCAGCTTCATCTCCCCGGGTGCCTTCAACGGGCTAACGGAGCTTCGGGAGCTGTCCCTCCAC
ACCAACGCACTGCAGGACCTGGACGGGAACGTCTTCCGCATGTTGGCCAACCTGCAGAACATCTCCCTGCAGAACAACCGCCTCAGACAGCTCCCAGGGAATATCTTCGCCAACGTCAATGGCCTCATGGCCATCCAGCTGCAGAACAAC
CAGCTGGAGAACTTGCCCCTCGGCATCTTCGATCACCTGGGGAAACTGTGTGAGCTGCGGCTGTATGACAATCCCTGGAGGTGTGACTCAGACATCCTTCCGCTCCGCAACTGGCTCCTGCTCAACCAGCCTAGGTTAGGGACGGACACT
GTACCTGTGTGTTTCAGCCCAGCCAATGTCCGAGGCCAGTCCCTCATTATCATCAATGTCAACGTTGCTGTTCCAAGCGTCCATGTCCCCGAGGTGCCTAGTTACCCAGAAACACCATGGTACCCAGACACACCCAGTTACCCTGACACC
ACATCCGTCTCTTCTACCACTGAGCTAACCAGCCCTGTGGAAGACTACACTGATCTGACTACCATTCAGGTCACTGATGACCGCAGCGTTTGGGGCATGACCCAGGCCCAGAGCGGGCTGGCCATTGCCGCCATTGTAATTGGCATTGTC
GCCCTGGCCTGCTCCCTGGCTGCCTGCGTCGGCTGTTGCTGCTGCAAGAAGAGGAGCCAAGCTGTCCTGATGCAGATGAAGGCACCCAATGAGTGTTAAAGAGGCAGGCTGGAGCAGGGCTGGGGAATGATGGGACTGGAGGACCTGGGA
ATTTCATCTTTCTGCCTCCACCCCTGGGTCCATGGAGCTTTCCCGTGATTGCTCTTTCTGGCCCCAGAGAAAGGTGAGCCTACCTCTTCCTGACTTGCCTGATTCTCCCGTAGAGAAGCAGGTCGTGCCGGACCTTCCTACAATCAGGAA
GATAGATCCAACTGGCCATGGCAAAAGCCCTGGGGATTTCCGATTCATACCCCTGGGCTTCCTTCGAGAGGGCTCTTCCTCCAAATCCTCCCCACCTGTCCTCCAAGAACAGCCTTCCCTGCGCCCAGGCCCCCTCCGGGCCTCTGTAGA
CTCAGTTAGTCCACAGCCTGCTCACTTCGTGGGAATAGTTCTCCGCTGAGATAGCCCCTCTCGCCTAAGTATTATGTAAGTTGATTTCCCTTCTTTTGTTTCTCTTGTTTGTGCTACGGCTTGACCCAGCATGTCCCCTCAAATGAAAGT
TCTCCCCTTGATTTTCTGCTCCTGAAGGCAGGGTGAGTTCTCTCCTCAAAGAAGACTTCAAACCATTTAACTGGTTTCTTAAGAGCCGTCAATCAGCCTGGTTTTGGGGATGCTATGAAAGAGAGAAGGAAAATCATGCCGCTCAGTTCC
TGGAGACAGAAGAGCCGTCATCAGTGTCTCACTTGTGATTTTTATCTGGAAAAGGAAGAAACACCCCAGCACAGCAAGCTCAGCCTTTTAGAGAAGGATATTTCCAAACTGCAAACTTTGCTTTGAAAAGTTTAGCCCTTTAAGGAATGA
AATCATGTAGAATTTTGGACTTCTAAAAACATTAAAATCAGCTTATTAATACGGGATAGAGAAAGAAATCTGGTGCCTGGGGGTCCCTGTGTTCACCCCTAGAGTTTGTTTTAAAATTTTTAATTGAAGCATGTGAAGTGTACGTGCAGA
AAAGTGGGAACATGATAGTGTATGGCTTGGTGGATTTTCACAAACTGAACATACCTGTGTAATCAGCATCTAGACCCAGACCCAGAGCATCACAAATATCCCCCATCCTGGGCTTTTCCCAGAGGAGATGGGGGCTTCTGAAGATGGACT
TACCTGGGACCTGCCCCCCATGAGCCAGGACGGTCCCCCCACAGTCAGCCTGTGCAAAGGCCCCGTGGCCAGGGGTGGAGGAGAATATGTGGGTGTGGACAGGATGGGAGACTGTGGCCTGAACAGGAGATTTTATTATATCTGGAGACC
CTGAGAGACCCTGAGACCTGGGGCACCATGGCTGGCCAGGTCAGAAGCATCCTGACTGCAGAGGTCCGTGCAGCCACACCCTCTTCCCTGCCAGCAAGCTGTCTGCGGCTCATCGGAGGCCCCTCCGCCTGGAGCCTTCTATGGACGTGA
TATGCCTGTATCTGTTTTTAATTTTCATTCTTCACTTAGGGGAAGTGAAATCGCTCAGAGATGAGATCCTTTAATTGAAAACGAAGTGTAACGGAATCTAGTGTCTTTCTAATGTGGTAAAATTCTCCATCAACATCACAGTCAGCTGGC
AGCTGAACTTCAGAATCTCACTTACAGCAGGCGACACGGGGGTACACCGATGGGTCACACTGGGTCTGGGGGCTCCCTGGAGCTCCTCCTGCGTGTGGTCTGGTTAGGAGTTGAGTTGTTTGCTCCAGGGTTATTCTCCTCCTCGAGTCA
CAGTCACACGAATACCTGCCTTCTCTGGCTTTCCTGCTATACACATATTCACATGGCGCTCAAGAAGTTAGGCTCATGGCAACGTGTGTCTTTCTCTGGACAACTGGCCCAGTTTACAGTGAAATGGAGAATTTCAGGTCTCCACGTCTG
CCCAGGAAAGAACTTCAGCTGACTCCACGGGGATCTGGAAATCCACGACCAATCCCGATCGGCTCTTATTAGCTCCCCGCTCCACAAGACACCTGTGCTTTGGAAATCCACCACCAATCCCGATCGGCTCTTATTAGCTCCCCGCTCCAC
AAGACACCTGTGATCTGGAAATCTACCACCAATCCCGATCGGCTCTTATTAGCTCCCCGCTCCACAAGACACCTGTGACATCCTCCAGGGCCACAGGAGCACGTGCTGACCAGTTTTCCCTTCCAGTTCCTGCACAAAAAGTGTCCAGAG
GGCTGTTTGCAAACACTAGTGCACTTTGTAGCTTTTCACCCTCTGTCCCAGGGAATCTAGGAGAGATGAGGCCCGTCAGAGTCAAGAGATGTCATCCCCCCAGGGTCTCCAAGGCATTTCCACACTATTGGTGGCACCTGGAGGACATGC
ACCAAGGCTTGCCAGAGCCAACAGGAAGTGAGCCCAGAGCATGGCACATGAGCATCACCCGCTGATGGTGGCCTGCTGTGCCTGGTGCCAACAGGGGCATCCCGGCCCGTACCCCTCCAGACAGGAAGCATGGGTTTGCCCACAGACCTG
TCGGGTGCTCCTGTGAGTGGCCTCCAGATGTCTTTGTGCATAGGCACAAGTGGGCCAGGGCTGGAGGGAGGTGGGAAACCTCATCATCCGGTGGGCCCTGCCAATCTTAACCCAGAACCCTTAGGTATTCCTGGCAGTAGCCATGACATT
GGAGCACCTTCCTCTCCAGCCAGAGGCTGACCTGAGGGCCACTGTCCTCAGATGACACCACCCAGGAGCACCCTAGGTGAGGGGTGAGGGCCCCCTTATGTGAACCTCTTGCCTCTTCCTTTCTCCCATCAGAGTGGTTGGATGGAGCCA
TTGGCCTCCTTTTCTTCAGCGGGCCCTTCAACCTCTCTGCACCATGTTGTCTGGCTGAGGAGCTACTAGAAAAGCTGAGTGGAGTCTCCTTTCCAACAGGATGATGCATTTGCTCAATTCTCAGGGCTGGAATGAGCCGGCTGGTCCCCC
AGAAAGCTGGAGTGGGGTACAGAGTTCAGTTTTCCTCTCTGTTTACAGCTCCTTGACAGTCCCACGCCCATCTGGAGTGGGAGCTGGGAGTCAGTGTTGGAGAAGAAACAACAAAAGCCAATTAGAACCACTATTTTTAAAAAGTGCTTA
CTGTGCACAGATACTCTTCAAGCACTGGACGTGGATTCTCTCTCTAGCCCTCAGCACCCCTGCGGTAGGAGTGCCGCCTCTACCCACTTGTGATGGGGTACAGAGGCACTTGCTCTTCTGCATGGTGTTCAATAGGCTGGGAGTTTTATT
TATCTCTTCAAACTTTGTACAAGAGCTCATGGCTTGTCTTGGGCTTTCGTCATTAAACCAAAGGAAATGGAAGCCATTCCCCTGTTGCTCTCCTTAGTCTTGGTCATCAGAACCTCACTTGGTACCATATAGATCAAAAGCTTTGTAACC
ACAGGAAAAAATAAACTCTTCCATCCCTTAAAGAATAGAATAGTTTGTCCCTCTCATGGGAATTGGGCTGTATGTATATTGTTCTTCCTCCTTAGAATTTAGAGATACAAGAGTTCTACTTAGAACTTTTCATGGACACAATTTCCACAA
CCTTTCAGATGCTGATGTAGAGCTATTGGGAAAGAACTTCCAAACTCAGGAAGTTTGCAGAGAGCAGACAGCTAGAGATAACTCGGGACCCAGAGTTGGTCGACAGATGTTAGATGTATCCTAGCTTTTAGCTATAAACCACTCAAAGAT
TCAGCCCCCAGATCCCACAGTCAGAACTGAATCTGCGTTGTTGGGAAGCCAGCAGTGGCCTTGGGAAGGAAGCCATGGCTGTGGTTCAGAGAGGGTGGGCTGGCAAGCCACTTCCGGGGAAAACTCCTTCCGCCCCAGGTTTCTTCTTCT
CTTAAGGAGAGATTGTTCTCACCAACCCGCTGCCTTCATGCTGCCTTCAAAGCTAGATCATGTTTGCCTTGCTTAGAGAATTACTGCAAATCAGCCCCAGTGCTTGGCGATGCATTTACAGATTTCTAGGCCCTCAGGGTTTTGTAGAGT
GTGAGCCCTGGTGGGCAGGGTTGGGGGGTCTGTCTTCTGCTGGATGCTGCTTGTAATCCATTTGGTGTACAGAATCAACAATAAATAATATACATGTATA

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for FGF12_LRRC15

In-frame Fusion Protein Sequences.

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for FGF12_LRRC15

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for FGF12_LRRC15

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		LUSC	TCGA-51-6867-01A	FGF12	chr3	192444969	-	LRRC15	chr3	194081775	-

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for FGF12_LRRC15

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status