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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:ANKRD26_MCM10 (FusionGDB2 ID:HG22852TG55388)

Fusion Gene Summary for ANKRD26_MCM10

Fusion gene summary

Fusion gene information	Fusion gene name: ANKRD26_MCM10
	Fusion gene ID: hg22852tg55388
		Hgene	Tgene
	Gene symbol	ANKRD26	MCM10
	Gene ID	22852	55388
	Gene name	ankyrin repeat domain containing 26	minichromosome maintenance 10 replication initiation factor
	Synonyms	THC2\|bA145E8.1	CNA43\|DNA43\|IMD80\|PRO2249
	Cytomap	10p12.1	10p13
	Type of gene	protein-coding	protein-coding
	Description	ankyrin repeat domain-containing protein 26GNS/ANKRD26/NCKAP1L fusionankyrin repeat domain 26	protein MCM10 homologMCM10 minichromosome maintenance deficient 10homolog of yeast MCM10hsMCM10minichromosome maintenance complex component 10
	Modification date	20240403	20240403
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000376087, ENST00000436985, ENST00000376070, ENST00000466890,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 6 X 8 X 6=288	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 3 X 9 X 4=108
	# samples	12	8
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(12/28810)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(8/10810)=-0.432959407276106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ANKRD26 [Title/Abstract] AND MCM10 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ANKRD26(27389013)-MCM10(13251090), # samples:1

Fusion gene breakpoints across ANKRD26 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MCM10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for ANKRD26_MCM10

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ANKRD26	chr10	27389013	MCM10	chr10	27389013
ANKRD26	chr10	27389014	MCM10	chr10	13251091
ANKRD26	chr10	27100085	MCM10	chr10	13209091

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for ANKRD26_MCM10

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

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Fusion Genomic Features for ANKRD26_MCM10

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ANKRD26	chr10	27389013	-	MCM10	chr10	13251090	+	3.68e-02	9.63e-01

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for ANKRD26_MCM10

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000376087	ENST00000378714	ANKRD26	chr10	27389013	-	MCM10	chr10	13251090	+
Frame-shift	ENST00000376087	ENST00000484800	ANKRD26	chr10	27389013	-	MCM10	chr10	13251090	+
Frame-shift	ENST00000436985	ENST00000378714	ANKRD26	chr10	27389013	-	MCM10	chr10	13251090	+
Frame-shift	ENST00000436985	ENST00000484800	ANKRD26	chr10	27389013	-	MCM10	chr10	13251090	+
In-frame	ENST00000376087	ENST00000378694	ANKRD26	chr10	27389013	-	MCM10	chr10	13251090	+
In-frame	ENST00000436985	ENST00000378694	ANKRD26	chr10	27389013	-	MCM10	chr10	13251090	+

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000376087	ENST00000378694	ANKRD26	chr10	27389013	MCM10	chr10	13251090	408	90
ENST00000436985	ENST00000378694	ANKRD26	chr10	27389013	MCM10	chr10	13251090	307	174

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000376087	ENST00000378694	ANKRD26	chr10	27389013	MCM10	chr10	13251090	5.29e-01	4.71e-01
ENST00000436985	ENST00000378694	ANKRD26	chr10	27389013	MCM10	chr10	13251090	4.70e-01	5.30e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for ANKRD26_MCM10

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ANKRD26

chr10:27389013

chr10:13251090

ENST00000376087

Q9UPS8

1_41

80.66666666666667

1711.0

Region

Disordered

Hgene

ANKRD26

chr10:27389013

chr10:13251090

ENST00000376087

Q9UPS8

45_75

80.66666666666667

1711.0

Repeat

Note=ANK 1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ANKRD26

chr10:27389013

chr10:13251090

ENST00000376087

Q9UPS8

1517_1587

80.66666666666667

1711.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ANKRD26

chr10:27389013

chr10:13251090

ENST00000376087

Q9UPS8

1649_1674

80.66666666666667

1711.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ANKRD26

chr10:27389013

chr10:13251090

ENST00000376087

Q9UPS8

529_566

80.66666666666667

1711.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ANKRD26

chr10:27389013

chr10:13251090

ENST00000376087

Q9UPS8

743_873

80.66666666666667

1711.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ANKRD26

chr10:27389013

chr10:13251090

ENST00000376087

Q9UPS8

905_1472

80.66666666666667

1711.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ANKRD26

chr10:27389013

chr10:13251090

ENST00000376087

Q9UPS8

569_580

80.66666666666667

1711.0

Compositional bias

Acidic residues

Hgene

ANKRD26

chr10:27389013

chr10:13251090

ENST00000376087

Q9UPS8

586_602

80.66666666666667

1711.0

Compositional bias

Basic and acidic residues

Hgene

ANKRD26

chr10:27389013

chr10:13251090

ENST00000376087

Q9UPS8

613_626

80.66666666666667

1711.0

Compositional bias

Basic and acidic residues

Hgene

ANKRD26

chr10:27389013

chr10:13251090

ENST00000376087

Q9UPS8

650_660

80.66666666666667

1711.0

Compositional bias

Acidic residues

Hgene

ANKRD26

chr10:27389013

chr10:13251090

ENST00000376087

Q9UPS8

661_673

80.66666666666667

1711.0

Compositional bias

Basic and acidic residues

Hgene

ANKRD26

chr10:27389013

chr10:13251090

ENST00000376087

Q9UPS8

222_274

80.66666666666667

1711.0

Region

Disordered

Hgene

ANKRD26

chr10:27389013

chr10:13251090

ENST00000376087

Q9UPS8

504_630

80.66666666666667

1711.0

Region

Disordered

Hgene

ANKRD26

chr10:27389013

chr10:13251090

ENST00000376087

Q9UPS8

650_698

80.66666666666667

1711.0

Region

Disordered

Hgene

ANKRD26

chr10:27389013

chr10:13251090

ENST00000376087

Q9UPS8

892_912

80.66666666666667

1711.0

Region

Disordered

Hgene

ANKRD26

chr10:27389013

chr10:13251090

ENST00000376087

Q9UPS8

112_141

80.66666666666667

1711.0

Repeat

Note=ANK 3

Hgene

ANKRD26

chr10:27389013

chr10:13251090

ENST00000376087

Q9UPS8

145_174

80.66666666666667

1711.0

Repeat

Note=ANK 4

Hgene

ANKRD26

chr10:27389013

chr10:13251090

ENST00000376087

Q9UPS8

178_207

80.66666666666667

1711.0

Repeat

Note=ANK 5

Hgene

ANKRD26

chr10:27389013

chr10:13251090

ENST00000376087

Q9UPS8

79_108

80.66666666666667

1711.0

Repeat

Note=ANK 2

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for ANKRD26_MCM10

In-frame Fusion Transcript Sequences.

>ANKRD26_MCM10_ENST00000376087_ENST00000378694_27389013_13251090 length=2422nt 
 Breakpoint=408nt
GTCTAGCGGGATCGCTTGCTTGGTAACCCGGAGGGAGAGATTGGAAACCGCGGAGTTTCCTTTGGGAGGCTGCGGCCAGCCGGGGCTGACTTGTTATGTTGGGCTCCGGAGGCCGTTAAGAGCCGAGAGAGACATGAGGTGTCTCTGAAG
CCCGGTCGCCTGGGCCATGAAGAAGATTTTTAGTAAGAAGGGCGAGTCGCCCTTGGGCTCCTTCGCGCGGCGGCAGAGGAGCAGCGCGGGAGGCGGGGGCGAGCCGGGGGAGGGCGCCTACTCGCAGCCCGGCTACCACGTCCGAGACCG
AGATCTCGGCAAGATCCACAAAGCTGCCAGCGCGGGTAATGTGGCGAAAGTGCAGCAGATCCTTTTGCTCAGGAAGAATGGCTTGAACGATAGAGACAAGATGAACAGTAACTGTGGCCTCTACAAATGGGAACGGGACGGAATGCTAAA
GGTATGCCATTTGCGTACTAATTTTTGACTCCTTTTAGTGACCCATGCTAATAATGTGGAACCATCTCCTATTAAAATATTTTCATTTTTCTAGGAAAAGACTGGTCCAAAGATAGGAGGAGAAACTCTGTTACCAAGAGGAGAAGAACA
TGCTAAATTTCTGAACAGCCTTAAATAACCCGAACTTCAGACATTTTCCCACAGACTTCCTGGCCTCCTGTGACTCTGGAAAGCAAAGGATTGGCTGTGTATTGTCCATTGATTCCTGATTGACGCCGTCAAAAACAAATGCTTGTTAAG
CCCATAAGCTTTGCCTGCTTACTTTCTGCCATTGGGTTGGTTTGATACCACATTTAACATTGACATTTAAGTGGAAAACCAAGTTATCATTGTCTTTTCTAAGCTCAGTGTGGATGATTGCATTACTTCATTCACTGAAGTTTTTGCCCA
AAAATTGGAAGGTAAACAGAGAGCTATGTTTCTGTATCTTTTGGTTATAGAGTGTTCACTTCTTTATCATAACAAAATTCTAGTGTTTATACGAACACCCAGAGGCAAAAGAATTTGGCTTAATTCTCACTCCAGGTAAGTAGCTTAACT
TCTGGGCTTCAGTTTTCTCATCTGTAAAATCAGGAAGATTGGACTAAGTGATCCTGAAATGTATTTTTTAGCACTGGATTTCTACAAATAATAAAACTTTCCCATCTAGATAATGATGATCACATAGTCTTGATGTACGGACATTAAAAG
CCAGATTTCTTCATTCAATTCTGTTATCTCTGTTTTACTCTTTGAAATTGATCAAGCCACTGAATCACTTTGCATTTCAGTTTATATATATAGAGAGAAAGAAGGTGTCTGCTCTTACATTATTGTGGAGCCCTGTGATAGAAATATGTA
AAATCTCATATTATTTTTTTTTTAATTTTTTTATTTTTTATGACAGGGTCTCACTATGTCACCCTGGCTGGAGTGCAGTAGTGCGATCGCGGCACACTGCAGCCTTGGCTTCCCTGGGCTCAAGCAGTCCTCCCACCTCAGTCTCCCAAA
TAGCTAGGACTACAGGCGTGCGTGACCAAGCCCAGCTAATTTTTGCATTTTTTGTAGAGATGGGGTTTTGCCATGTTGCTCAGGCTGGTCTCAAACTCCTGAGCACTAGCAATCCACCCACCTCTGTTTCCAAAAAAAAAAAAAAAATGA
AAGGTCAACCCCTATGCAAATTACCACAGCAAAGGTTTCATTCAGGAGATTCTTCCATCTGGGCAACCTGGTTTTCCAAATATCATTTGACCTAAGTGAATGTTGATACTAGCTAAAGATTGGGTAAATTGGTTGAATTATTGTATTGAA
GCTTGAGCTGTAGCTAAAAGTAATTTAGGTTTCCCCTAAGATGTTATTATGTTAGGGACATAACACTTTTGGGAGGTTGTTGTGGGAGATGGTTGATTTAGGTTTTCAAAAGCTAGAAATAAAATTTACATGCCTTAGATTTCATAAAAT
TCTGCTCTAATTGGGTGGAAGGTGCTGTATCTAACTTGTGTTCCTCCTAAGGTTATGTCCTAATAACTATTCTTTTAGGAGTATACTTCTACTTTATAGAAGGTTGCTTTTCTTTTTAATTTTTTCTAACAAAGAAAAGAATAAAGTATT
TATTAATAAGAACCAGAAAGCACTTGAAACTGATGTTTTTAATGGCTCATTTAGGGTAGATTTATTTATCTCATTAACTTAAAACAGCTATGTGTATGAAATAGGTCACAACAGAACTTGAACACCAGGTTGGTGTCTGAGCAATCCCTT
TCTTATGGGAAAAACAATGTTCTTGTTTGAACAGAGGGTATCATTGCAGTCAGTATTCACGTGTATATTGTTATATAAGTTGTATAATATGCTTGTAAAGGCTGAGGGTGAGCTGTATCTGGATGCCTTTTTACAATTTGATTTTAACTT
TTAAAATAAATTTAAAACATAA

>ANKRD26_MCM10_ENST00000436985_ENST00000378694_27389013_13251090 length=2321nt 
 Breakpoint=307nt
GGCTCCGGAGGCCGTTAAGAGCCGAGAGAGACATGAGGTGTCTCTGAAGCCCGGTCGCCTGGGCCATGAAGAAGATTTTTAGTAAGAAGGGCGAGTCGCCCTTGGGCTCCTTCGCGCGGCGGCAGAGGAGCAGCGCGGGAGGCGGGGGCG
AGCCGGGGGAGGGCGCCTACTCGCAGCCCGGCTACCACGTCCGAGACCGAGATCTCGGCAAGATCCACAAAGCTGCCAGCGCGGGTAATGTGGCGAAAGTGCAGCAGATCCTTTTGCTCAGGAAGAATGGCTTGAACGATAGAGACAAGA
TGAACAGTAACTGTGGCCTCTACAAATGGGAACGGGACGGAATGCTAAAGGTATGCCATTTGCGTACTAATTTTTGACTCCTTTTAGTGACCCATGCTAATAATGTGGAACCATCTCCTATTAAAATATTTTCATTTTTCTAGGAAAAGA
CTGGTCCAAAGATAGGAGGAGAAACTCTGTTACCAAGAGGAGAAGAACATGCTAAATTTCTGAACAGCCTTAAATAACCCGAACTTCAGACATTTTCCCACAGACTTCCTGGCCTCCTGTGACTCTGGAAAGCAAAGGATTGGCTGTGTA
TTGTCCATTGATTCCTGATTGACGCCGTCAAAAACAAATGCTTGTTAAGCCCATAAGCTTTGCCTGCTTACTTTCTGCCATTGGGTTGGTTTGATACCACATTTAACATTGACATTTAAGTGGAAAACCAAGTTATCATTGTCTTTTCTA
AGCTCAGTGTGGATGATTGCATTACTTCATTCACTGAAGTTTTTGCCCAAAAATTGGAAGGTAAACAGAGAGCTATGTTTCTGTATCTTTTGGTTATAGAGTGTTCACTTCTTTATCATAACAAAATTCTAGTGTTTATACGAACACCCA
GAGGCAAAAGAATTTGGCTTAATTCTCACTCCAGGTAAGTAGCTTAACTTCTGGGCTTCAGTTTTCTCATCTGTAAAATCAGGAAGATTGGACTAAGTGATCCTGAAATGTATTTTTTAGCACTGGATTTCTACAAATAATAAAACTTTC
CCATCTAGATAATGATGATCACATAGTCTTGATGTACGGACATTAAAAGCCAGATTTCTTCATTCAATTCTGTTATCTCTGTTTTACTCTTTGAAATTGATCAAGCCACTGAATCACTTTGCATTTCAGTTTATATATATAGAGAGAAAG
AAGGTGTCTGCTCTTACATTATTGTGGAGCCCTGTGATAGAAATATGTAAAATCTCATATTATTTTTTTTTTAATTTTTTTATTTTTTATGACAGGGTCTCACTATGTCACCCTGGCTGGAGTGCAGTAGTGCGATCGCGGCACACTGCA
GCCTTGGCTTCCCTGGGCTCAAGCAGTCCTCCCACCTCAGTCTCCCAAATAGCTAGGACTACAGGCGTGCGTGACCAAGCCCAGCTAATTTTTGCATTTTTTGTAGAGATGGGGTTTTGCCATGTTGCTCAGGCTGGTCTCAAACTCCTG
AGCACTAGCAATCCACCCACCTCTGTTTCCAAAAAAAAAAAAAAAATGAAAGGTCAACCCCTATGCAAATTACCACAGCAAAGGTTTCATTCAGGAGATTCTTCCATCTGGGCAACCTGGTTTTCCAAATATCATTTGACCTAAGTGAAT
GTTGATACTAGCTAAAGATTGGGTAAATTGGTTGAATTATTGTATTGAAGCTTGAGCTGTAGCTAAAAGTAATTTAGGTTTCCCCTAAGATGTTATTATGTTAGGGACATAACACTTTTGGGAGGTTGTTGTGGGAGATGGTTGATTTAG
GTTTTCAAAAGCTAGAAATAAAATTTACATGCCTTAGATTTCATAAAATTCTGCTCTAATTGGGTGGAAGGTGCTGTATCTAACTTGTGTTCCTCCTAAGGTTATGTCCTAATAACTATTCTTTTAGGAGTATACTTCTACTTTATAGAA
GGTTGCTTTTCTTTTTAATTTTTTCTAACAAAGAAAAGAATAAAGTATTTATTAATAAGAACCAGAAAGCACTTGAAACTGATGTTTTTAATGGCTCATTTAGGGTAGATTTATTTATCTCATTAACTTAAAACAGCTATGTGTATGAAA
TAGGTCACAACAGAACTTGAACACCAGGTTGGTGTCTGAGCAATCCCTTTCTTATGGGAAAAACAATGTTCTTGTTTGAACAGAGGGTATCATTGCAGTCAGTATTCACGTGTATATTGTTATATAAGTTGTATAATATGCTTGTAAAGG
CTGAGGGTGAGCTGTATCTGGATGCCTTTTTACAATTTGATTTTAACTTTTAAAATAAATTTAAAACATAA

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for ANKRD26_MCM10

In-frame Fusion Protein Sequences.

>ANKRD26_MCM10_ENST00000376087_ENST00000378694_27389013_13251090 length=90nt
MCSGPAQSLGVFPSYLPVHSFQRTYGREVHDAPHSNLLWAGRMPERLTHSLIKVSQSIGFPCWSFTGLLHLYSSLNLLEVFLMNIKILPG

>ANKRD26_MCM10_ENST00000436985_ENST00000378694_27389013_13251090 length=174nt
MLSLFYSLKLIKPLNHFAFQFIYIERKKVSALTLLWSPVIEICKISYYFFFNFFIFYDRVSLCHPGWSAVVRSRHTAALASLGSSSPPTSVSQIARTTGVRDQAQLIFAFFVEMGFCHVAQAGLKLLSTSNPPTSVSKKKKKMKGQPLCK
LPQQRFHSGDSSIWATWFSKYHLT

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for ANKRD26_MCM10

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for ANKRD26_MCM10

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		BLCA	TCGA-XF-A8HD-01A	ANKRD26	chr10	27389013	-	MCM10	chr10	27389013	+
WashU		BLCA	TCGA-XF-A8HD-01A	ANKRD26	chr10	27389014	-	MCM10	chr10	13251091	+
cBioPortal	BLCA_TCGA_PAN_CAN_ATLAS_2018	BLCA	TCGA-XF-A8HD-01	ANKRD26	chr10	27100085		MCM10	chr10	13209091

DNA-seq based fusion gene expressed samples.

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Related Drugs for ANKRD26_MCM10

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

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