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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:SLC9A8_TOM1L2 (FusionGDB2 ID:HG23315TG146691)

Fusion Gene Summary for SLC9A8_TOM1L2

Fusion gene summary

Fusion gene information	Fusion gene name: SLC9A8_TOM1L2
	Fusion gene ID: hg23315tg146691
		Hgene	Tgene
	Gene symbol	SLC9A8	TOM1L2
	Gene ID	23315	146691
	Gene name	solute carrier family 9 member A8	target of myb1 like 2 membrane trafficking protein
	Synonyms	NHE-8\|NHE8	-
	Cytomap	20q13.13	17p11.2
	Type of gene	protein-coding	protein-coding
	Description	sodium/hydrogen exchanger 8Na(+)/H(+) exchanger 8solute carrier family 9 (sodium/hydrogen exchanger), member 8solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8	TOM1-like protein 2target of Myb-like protein 2target of myb1-like 2
	Modification date	20240403	20240407
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000361573, ENST00000417961, ENST00000539601, ENST00000541138, ENST00000490250,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 9 X 8 X 8=576	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 7 X 12 X 9=756
	# samples	15	25
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(15/57610)=-1.94110631094643 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(25/75610)=-1.59645813955899 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SLC9A8 [Title/Abstract] AND TOM1L2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SLC9A8(48431726)-TOM1L2(17754266), # samples:1

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Fusion Gene Breakpoints for SLC9A8_TOM1L2

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
SLC9A8	chr20	48431726	TOM1L2	chr17	17754266
SLC9A8	chr20	49815189	TOM1L2	chr17	17850952

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for SLC9A8_TOM1L2

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
SLC9A8-TOM1L2	Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions M1		Promoter swap alters NHE8 sodium/proton exchanger expression alongside TOM1L2, coordinating pH regulation with endosomal trafficking and receptor degradation.		Endocytosis modulators; endomembrane blockers		Carcinomas and solid tumors

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
SLC9A8-TOM1L2	Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions M1		Promoter swap alters NHE8 sodium/proton exchanger expression alongside TOM1L2, coordinating pH regulation with endosomal trafficking and receptor degradation.		Endocytosis modulators; endomembrane blockers		Carcinomas and solid tumors	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 15540165; Title: Gene amplifications in osteosarcoma-CGH microarray analysis.; PMID: 17366602; Title: COPS3 amplification and clinical outcome in osteosarcoma.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SLC9A8	GO:0035725	sodium ion transmembrane transport	15522866
Hgene	SLC9A8	GO:1902600	proton transmembrane transport	15522866
Hgene	SLC9A8	GO:1905526	regulation of Golgi lumen acidification	15522866
Tgene	TOM1L2	GO:0007165	signal transduction	16479011
Tgene	TOM1L2	GO:0045839	negative regulation of mitotic nuclear division	16479011

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Fusion Genomic Features for SLC9A8_TOM1L2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
SLC9A8	chr20	48431726	+	TOM1L2	chr17	17754266	-	1.46e-05	1.00e+00
SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-	9.19e-01	8.08e-02

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-	9.19e-01	8.08e-02

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for SLC9A8_TOM1L2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000539601	ENST00000318094	SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-
5UTR-3CDS	ENST00000539601	ENST00000379504	SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-
5UTR-3CDS	ENST00000539601	ENST00000395739	SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-
5UTR-3CDS	ENST00000539601	ENST00000535933	SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-
5UTR-3CDS	ENST00000539601	ENST00000581396	SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-
5UTR-3CDS	ENST00000541138	ENST00000318094	SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-
5UTR-3CDS	ENST00000541138	ENST00000379504	SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-
5UTR-3CDS	ENST00000541138	ENST00000395739	SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-
5UTR-3CDS	ENST00000541138	ENST00000535933	SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-
5UTR-3CDS	ENST00000541138	ENST00000581396	SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-
Frame-shift	ENST00000361573	ENST00000318094	SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-
Frame-shift	ENST00000361573	ENST00000379504	SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-
Frame-shift	ENST00000361573	ENST00000395739	SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-
Frame-shift	ENST00000361573	ENST00000535933	SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-
Frame-shift	ENST00000361573	ENST00000581396	SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-
Frame-shift	ENST00000417961	ENST00000318094	SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-
Frame-shift	ENST00000417961	ENST00000379504	SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-
Frame-shift	ENST00000417961	ENST00000395739	SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-
Frame-shift	ENST00000417961	ENST00000535933	SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-
Frame-shift	ENST00000417961	ENST00000581396	SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000539601	ENST00000318094	SLC9A8	chr20	48431726	TOM1L2	chr17	17754266	0	129
ENST00000539601	ENST00000379504	SLC9A8	chr20	48431726	TOM1L2	chr17	17754266	0	344
ENST00000539601	ENST00000395739	SLC9A8	chr20	48431726	TOM1L2	chr17	17754266	0	172
ENST00000539601	ENST00000535933	SLC9A8	chr20	48431726	TOM1L2	chr17	17754266	0	110
ENST00000539601	ENST00000581396	SLC9A8	chr20	48431726	TOM1L2	chr17	17754266	0	138
ENST00000541138	ENST00000318094	SLC9A8	chr20	48431726	TOM1L2	chr17	17754266	0	129
ENST00000541138	ENST00000379504	SLC9A8	chr20	48431726	TOM1L2	chr17	17754266	0	344
ENST00000541138	ENST00000395739	SLC9A8	chr20	48431726	TOM1L2	chr17	17754266	0	172
ENST00000541138	ENST00000535933	SLC9A8	chr20	48431726	TOM1L2	chr17	17754266	0	110
ENST00000541138	ENST00000581396	SLC9A8	chr20	48431726	TOM1L2	chr17	17754266	0	138

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000539601	ENST00000318094	SLC9A8	chr20	48431726	TOM1L2	chr17	17754266	0.00e+00	4.21e-01
ENST00000539601	ENST00000379504	SLC9A8	chr20	48431726	TOM1L2	chr17	17754266	0.00e+00	6.07e-01
ENST00000539601	ENST00000395739	SLC9A8	chr20	48431726	TOM1L2	chr17	17754266	0.00e+00	1.87e-01
ENST00000539601	ENST00000535933	SLC9A8	chr20	48431726	TOM1L2	chr17	17754266	0.00e+00	2.64e-01
ENST00000539601	ENST00000581396	SLC9A8	chr20	48431726	TOM1L2	chr17	17754266	0.00e+00	9.12e-01
ENST00000541138	ENST00000318094	SLC9A8	chr20	48431726	TOM1L2	chr17	17754266	0.00e+00	4.21e-01
ENST00000541138	ENST00000379504	SLC9A8	chr20	48431726	TOM1L2	chr17	17754266	0.00e+00	6.07e-01
ENST00000541138	ENST00000395739	SLC9A8	chr20	48431726	TOM1L2	chr17	17754266	0.00e+00	1.87e-01
ENST00000541138	ENST00000535933	SLC9A8	chr20	48431726	TOM1L2	chr17	17754266	0.00e+00	2.64e-01
ENST00000541138	ENST00000581396	SLC9A8	chr20	48431726	TOM1L2	chr17	17754266	0.00e+00	9.12e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for SLC9A8_TOM1L2

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for SLC9A8_TOM1L2

In-frame Fusion Transcript Sequences.

N-Truncated Transcript (5UTR-3CDS) Sequences

>SLC9A8_TOM1L2_ENST00000539601_ENST00000318094_48431726_17754266 length=1032nt 
 Breakpoint=0nt
ATCCCCGTTGCGCAGCCATCTGTCATGGACGACATTGAGGTGTGGCTCAGGACCGACCTGAAGGGTGATGATCTGGAGGAGGGTGTCACAAGTGAAGAGTTTGATAAATTCCTTGAAGAAAGAGCCAAAGCTGCTGAAATGGTTCCCGAC
CTCCCCTCGCCCCCCATGGAGGCTCCTGCCCCAGCCTCAAACCCTTCTGGCCGGAAGAAGCCAGAGCGGTCAGAGGATGCCCTCTTCGCCCTGTGAGCAGCTCTGTGGTTTGCCTCCCCAGATGGCGGGTCCCCGCTCGCACCCCGTGGA
CACCGGGCACTGGCCACTCCTACATCCCCAGCTCCACACGGCCTGCACACCTGTGTTTCCATGGAAATGCCACCGTGTCTGCTCCCAGGCCTCCCACTAGTCAGGACCAGCTTCAGCCACTTCTTTTCTCTGAGTGGTGGGACAACTGCA
GCCAGAGACTCTCTCCCCTCCCACCATGGGCCCCTCTGCCCATGTTTCCTCCCAGGAAGAGCGGGCAGAGTGGCCCAGCCCCAGGCAGTGCTTCCTGAGCAGACCACCCGGACTGTCTTTCCTCCACCCGCCCATGGAGAAAGAGCACGC
CCGGCCCCGCCCTGTGCTCACCTCTGCCTGGCTCAGCGACCTTCTCAGGCATTCTGCCCTCCTGGGCCCCTCTCTCCCTGAAGGGGCTTTGTGGCATCTCTGGAAGAGCAGGGTGTGCTGCACTCATGGGCCTGGTCTCACTCCTTGGAC
TTGTCACCTTGTGACATTTGGCTTATCAGCATTTGAGAAGGCTCTGCTGGGTCTCCATGGTGGGGGTCTCTCACCTTCTTGACCCTCTCTCCATCATTCAGCTGCCAGCCCAGGCTTCACACCCAAGCTGGCTCAGCAGCCGAGCCTGGC
ACCGAGGGTCCCTGCAGGCTCCCTGGGCAGGGAGAGGGCCAAGGACAATTGGGAGGGCAGCAGGCAGCCCGCAGATGGTGGCCATGTGGCACGCTGCTGAGACGACACTACCAATAAACCAAACTGCCACGC

>SLC9A8_TOM1L2_ENST00000539601_ENST00000379504_48431726_17754266 length=1056nt 
 Breakpoint=0nt
ATCCCCGTTGCGCAGCCATCTGTCATGGACGACATTGAGGTGTGGCTCAGGACCGACCTGAAGGGTGATGATCTGGAGGAGGGTGTCACAAGTGAAGAGTTTGATAAATTCCTTGAAGAAAGAGCCAAAGCTGCTGAAATGGTTCCCGAC
CTCCCCTCGCCCCCCATGGAGGCTCCTGCCCCAGCCTCAAACCCTTCTGGCCGGAAGAAGCCAGAGCGGTCAGAGGATGCCCTCTTCGCCCTGTGAGCAGCTCTGTGGTTTGCCTCCCCAGATGGCGGGTCCCCGCTCGCACCCCGTGGA
CACCGGGCACTGGCCACTCCTACATCCCCAGCTCCACACGGCCTGCACACCTGTGTTTCCATGGAAATGCCACCGTGTCTGCTCCCAGGCCTCCCACTAGTCAGGACCAGCTTCAGCCACTTCTTTTCTCTGAGTGGTGGGACAACTGCA
GCCAGAGACTCTCTCCCCTCCCACCATGGGCCCCTCTGCCCATGTTTCCTCCCAGGAAGAGCGGGCAGAGTGGCCCAGCCCCAGGCAGTGCTTCCTGAGCAGACCACCCGGACTGTCTTTCCTCCACCCGCCCATGGAGAAAGAGCACGC
CCGGCCCCGCCCTGTGCTCACCTCTGCCTGGCTCAGCGACCTTCTCAGGCATTCTGCCCTCCTGGGCCCCTCTCTCCCTGAAGGGGCTTTGTGGCATCTCTGGAAGAGCAGGGTGTGCTGCACTCATGGGCCTGGTCTCACTCCTTGGAC
TTGTCACCTTGTGACATTTGGCTTATCAGCATTTGAGAAGGCTCTGCTGGGTCTCCATGGTGGGGGTCTCTCACCTTCTTGACCCTCTCTCCATCATTCAGCTGCCAGCCCAGGCTTCACACCCAAGCTGGCTCAGCAGCCGAGCCTGGC
ACCGAGGGTCCCTGCAGGCTCCCTGGGCAGGGAGAGGGCCAAGGACAATTGGGAGGGCAGCAGGCAGCCCGCAGATGGTGGCCATGTGGCACGCTGCTGAGACGACACTACCAATAAACCAAACTGCCACGCACACACTGCAGGCTCACA
CCCGCA

>SLC9A8_TOM1L2_ENST00000539601_ENST00000395739_48431726_17754266 length=532nt 
 Breakpoint=0nt
ATCCCCGTTGCGCAGCCATCTGTCATGGACGACATTGAGGTGTGGCTCAGGACCGACCTGAAGGGTGATGATCTGGAGGAGGGTGTCACAAGTGAAGAGTTTGATAAATTCCTTGAAGAAAGAGCCAAAGCTGCTGAAATGGTTCCCGAC
CTCCCCTCGCCCCCCATGGAGGCTCCTGCCCCAGCCTCAAACCCTTCTGGCCGGAAGAAGCCAGAGCGGTCAGAGGATGCCCTCTTCGCCCTGTGAGCAGCTCTGTGGTTTGCCTCCCCAGATGGCGGGTCCCCGCTCGCACCCCGTGGA
CACCGGGCACTGGCCACTCCTACATCCCCAGCTCCACACGGCCTGCACACCTGTGTTTCCATGGAAATGCCACCGTGTCTGCTCCCAGGCCTCCCACTAGTCAGGACCAGCTTCAGCCACTTCTTTTCTCTGAGTGGTGGGACAACTGCA
GCCAGAGACTCTCTCCCCTCCCACCATGGGCCCCTCTGCCCATGTTTCCTCCCAGGAAGAGCGGGCAGAGTGGCCCAGCCCC

>SLC9A8_TOM1L2_ENST00000539601_ENST00000535933_48431726_17754266 length=435nt 
 Breakpoint=0nt
ATCCCCGTTGCGCAGCCATCTGTCATGGACGACATTGAGGTGTGGCTCAGGACCGACCTGAAGGGTGATGATCTGGAGGAGGGTGTCACAAGTGAAGAGTTTGATAAATTCCTTGAAGAAAGAGCCAAAGCTGCTGAAATGGTTCCCGAC
CTCCCCTCGCCCCCCATGGAGGCTCCTGCCCCAGCCTCAAACCCTTCTGGCCGGAAGAAGCCAGAGCGGTCAGAGGATGCCCTCTTCGCCCTGTGAGCAGCTCTGTGGTTTGCCTCCCCAGATGGCGGGTCCCCGCTCGCACCCCGTGGA
CACCGGGCACTGGCCACTCCTACATCCCCAGCTCCACACGGCCTGCACACCTGTGTTTCCATGGAAATGCCACCGTGTCTGCTCCCAGGCCTCCCACTAGTCAGGACCAGCTTCAGCCACTTCTTTTCTCTGAGT

>SLC9A8_TOM1L2_ENST00000539601_ENST00000581396_48431726_17754266 length=4367nt 
 Breakpoint=0nt
ATCCCCGTTGCGCAGCCATCTGTCATGGACGACATTGAGGTGTGGCTCAGGACCGACCTGAAGGGTGATGATCTGGAGGAGGGTGTCACAAGTGAAGAGTTTGATAAATTCCTTGAAGAAAGAGCCAAAGCTGCTGAAATGGTTCCCGAC
CTCCCCTCGCCCCCCATGGAGGCTCCTGCCCCAGCCTCAAACCCTTCTGGCCGGAAGAAGCCAGAGCGGTCAGAGGATGCCCTCTTCGCCCTGTGAGCAGCTCTGTGGTTTGCCTCCCCAGATGGCGGGTCCCCGCTCGCACCCCGTGGA
CACCGGGCACTGGCCACTCCTACATCCCCAGCTCCACACGGCCTGCACACCTGTGTTTCCATGGAAATGCCACCGTGTCTGCTCCCAGGCCTCCCACTAGTCAGGACCAGCTTCAGCCACTTCTTTTCTCTGAGTGGTGGGACAACTGCA
GCCAGAGACTCTCTCCCCTCCCACCATGGGCCCCTCTGCCCATGTTTCCTCCCAGGAAGAGCGGGCAGAGTGGCCCAGCCCCAGGCAGTGCTTCCTGAGCAGACCACCCGGACTGTCTTTCCTCCACCCGCCCATGGAGAAAGAGCACGC
CCGGCCCCGCCCTGTGCTCACCTCTGCCTGGCTCAGCGACCTTCTCAGGCATTCTGCCCTCCTGGGCCCCTCTCTCCCTGAAGGGGCTTTGTGGCATCTCTGGAAGAGCAGGGTGTGCTGCACTCATGGGCCTGGTCTCACTCCTTGGAC
TTGTCACCTTGTGACATTTGGCTTATCAGCATTTGAGAAGGCTCTGCTGGGTCTCCATGGTGGGGGTCTCTCACCTTCTTGACCCTCTCTCCATCATTCAGCTGCCAGCCCAGGCTTCACACCCAAGCTGGCTCAGCAGCCGAGCCTGGC
ACCGAGGGTCCCTGCAGGCTCCCTGGGCAGGGAGAGGGCCAAGGACAATTGGGAGGGCAGCAGGCAGCCCGCAGATGGTGGCCATGTGGCACGCTGCTGAGACGACACTACCAATAAACCAAACTGCCACGCACACACTGCAGGCTCACA
CCCGCACACCTGGTCCTGGCTTGTGGAGGGACTTGCACTGGAGGTATTGCTCTGGCTTGCCTGGGGAAGTGTCACAGATGTGCACATGGGCCACACTCAGTGCTGTGGCCTGGCCTGCCGTAGCCTCACACATCTGCCTCAAGAGCCAGC
AGCAAACAGCTTTGTGGCATCCTTGGAGGTTCCCAGTGACTGAGAGGCCTGGGCAGCACTAAGGCCCCTGCTCTGCTCCCTGGCATAGGCCTTGGCCTCCTTGCACAGACTCTCCTGACAGTCTGGCCTCCTCCCACCTCAGAGGTCCTC
TGGCCACCAATTTATACTCTCTCCCCAAGCTGATCCTGAAGGCAGGCAGAGCAGCTAGGGGCTGGTAACATGTATTCCCATCCCGTGTCCTCACTGGTGTGTCTCCTGGCCATGGGCAAGGGACTCGGGTCATCCCAGGCCCTGGTCCAG
CCAGACACCTGGCCCCACACCTCCCACCAGGCTGCTGTTGCTCAGAAGGAGAATACTGCAGCTGTATGCATCCCCGTGTGTCTTGGGCCCAGCTCGCTGGGTCAGTCTGCTCCTGTCCCCTCCAGCATGCACTGCCTAGGTCAGCACAGG
TTCCTGATCCATGGTGTAGTTAGCCCTTCCCACCTGGCAGGACGGCCCAGACCACCAGCCAAGCAGGGAAAGGGGGCTGGGCTTGACGGGAGAAGAGACCAGCGACATGGTCGTTGGGGAGCATTCAGGATGGCGACTTCAGCTGGGGGT
CATGCTGAGCACCAACAGGAACTATTCCAGTGAAGAGCAAGTGCTGCCCGACCCAGGACCCTGTGCCAGGCTAGCAGCCCTCCAGCTCCCTCCAGAGAGGAAACCTCTGTCTGGCTGAGGGTGGGACTAGCTGGGATGTCTCACTCCAGT
TGCTCAGGTTCACCCAGGAAGCTCCTCCGTGGAGTGGCCAGCCTGATTCTAGCCCTGTCCTCTCTGGCAGCACATGCCACACCTGCCTGGGCCTTCTGCTCCCTGATGCTTGATGAGCCCCTGCCTCCTCAATGTTTCTCAAAGACAGAC
CCCCCTGAGGCCAGCTTGAATGTGAAGACTGCTGAAGTTAGCTGGCTTCACTTGAGCTGCAGAAAAGGTGGCTGGGATGGCCCAGGTGCACCCAGAGGCCCCAGCCCTTTGGCTGCCTTTGGGTTGTGACTTGGGTTGTCTCTGAGGCCC
TGCCAGAGCTGGGCCTGCGGGTGGTGGGCGGTCCGACCTCGGGCAGTCAGTGCTCCGCAGCCTCAGCACTGCATCCCAGACCCAGTGTCCTCAGAGGGAAGAGCCAGCCTCCCTGCCTCATGGAACCAGGAGTCCCAAAAAGTCAGGAGC
CTGGAGGCTCTGAAAGGAGCAGGGATTCCATAGTGCGTGAAGCTGAAATAGGCGCCCTCCTGGGGAGCCCCCAGCAAAACTGTTTTTCATACCCACTCCCAGAACTGCCCCGCTCCAGCTCCAGCGCCAGCGCCAGCTGGTTGCCAGGCA
TCATTGGAGAGGCCTGGCTGCCCCAGGGGCAGCAGGGAGTGGTGGACCTGTATGGGCTGGCAGGAGGCCATTGGCCATGCTGACAAGTGTCACCTGCCTTCCTAGCCTGGAGCCACCCCTCAGGTGGCCTGCTTGCACCTCCTATCCGGA
GGTAGCCTGCCCCACCTGTAGGCAGAGGGGGCTCTTGCTTGAGGCCTGCACAGGAAGCAAGTATAGCCCCGGTGCCCCAGAGTGGGTTCCACTTAGCCCTGGCGAGATGGCCTGTCCTGAGATCTCTGCTCCCAGACCCCACCATCTGGG
GAGCACAGTCCTTAGGCTGCCTGGTCCAGGAAGGGGGTGCGGCTCTGTCAGGAAACCTGGACTCTCAAGGCCCACCAGCCTCTCCGTGAGTGTTAGAAATCACAGATACAGTATATACTTAATTACACTAAATTATTGCTGGGATTCCTT
ATAAGCACTAATTATACCTGATTATAGGTTAAAATATTTATTTTGTCAAAATATTTTCTTGGGAATGTGTTTAACCCTTTCTGCGTTCATTGTTGCTGAGATGTGAAAACTAACCATTCCCTCCTGCCTACCTTTTTGGCCACTGGGCGG
CAGAGAATGGCGCTATGTGCAGTTGGGCCCCTGGCACCATGGGCCTTTGGCCTGCCTGCTGCAGAGTAGCCCTGCCTGGGCAGTCTCCAGGCACTGAGCAGGCCATCTGTGGCCAGGCTGAGAGAATGACTGGCTCGCTTACCAGCGTGC
ATGGGACAAGGAGCTTTGGAGCCTCAAGGGGTTGTTGCTGGCCTGGGCTAGAGGGAAAGGTGACCATCCGTCTGTCCTCCTGTCTTTCTATTAGCGCCTCCATGTGAGTGATGGTGCCTTGGTTCACTAGCCTTCCCCCACCACCCCACC
ATGCCACCTGGTGGTCTTGGGGCCTGTGCTGTCACTCCAGCCCCTGGGGAGGAGAGGACCCAGCCCGGAGAGTTGGGGCAAGGGCTCCACATGGCCCAAGGGCAACAGATGCTCGCAGGGCAGCTGCTGCCGATGCTCACGCTCCTGCCC
CCCTCCTTCCCGCTGCCACACCCCACCCTGGGCCCCCGCAGACACGCATCTCTAACTCAGTTGGGCCCAGCCTTCTGGATGGCTTGGGGTAGGCCATGGGCCCACCTGGGGCCAGGCCAGCCCCTGGGGCAGCTCTGGAAGAGCAGTGTG
GAGGAGCACTTGCTTGCAGCCTGGCTTCAGCCTCTGGCACTGCTGGAGTGGTCCCTGGGAGCTTCTGCACTGTCGGCTTTGGGGACGTCTCACCCACTTGGGTTACAGTAGGCCTTCCCCACCCAGAGAGAAGTGTTTCCACCCCAGAGA
CATTGTCTGTCAGCCCCTGAAGTGCTCGCCTCCCCCAGTGCCCGTCACCAGCCCTTCCTATCTGTGGGGTCCAAGTCAGGCTTCCCCTGCGGCCACCAGCCATAGGGAGCAGCCATCAGCCCCCGAGTCAGAACTGCTTCTGTCTGTCCA
TACCTCCAGGCTCTCCCGGAGAGGGGGACGGATATTTATTTCCTAAAGTTTGCACTTAATTGTGAGGATTCTCAGGATTGTTGGGGGCTACTGAAAAGAGGAATGTGTTGAATGTCGCGTTTGCTGTCCACTCGTCCTAGAAGTTTAGTG
TTTTTGTCACTGTCATGTGTTTCTGTGGGCAGAGCTGGTTCTGGAGGGTGGGTCAGTGCACCCGAGGCTCAGAGCATCCATCCACCCCACTGGCCCTCCTTCCAGATACCCTCTCTCTAATTGGGTTCTTGCATGTAAAATACTCCACAA
TAAATAAATAATTGAAC

>SLC9A8_TOM1L2_ENST00000541138_ENST00000318094_48431726_17754266 length=1032nt 
 Breakpoint=0nt
ATCCCCGTTGCGCAGCCATCTGTCATGGACGACATTGAGGTGTGGCTCAGGACCGACCTGAAGGGTGATGATCTGGAGGAGGGTGTCACAAGTGAAGAGTTTGATAAATTCCTTGAAGAAAGAGCCAAAGCTGCTGAAATGGTTCCCGAC
CTCCCCTCGCCCCCCATGGAGGCTCCTGCCCCAGCCTCAAACCCTTCTGGCCGGAAGAAGCCAGAGCGGTCAGAGGATGCCCTCTTCGCCCTGTGAGCAGCTCTGTGGTTTGCCTCCCCAGATGGCGGGTCCCCGCTCGCACCCCGTGGA
CACCGGGCACTGGCCACTCCTACATCCCCAGCTCCACACGGCCTGCACACCTGTGTTTCCATGGAAATGCCACCGTGTCTGCTCCCAGGCCTCCCACTAGTCAGGACCAGCTTCAGCCACTTCTTTTCTCTGAGTGGTGGGACAACTGCA
GCCAGAGACTCTCTCCCCTCCCACCATGGGCCCCTCTGCCCATGTTTCCTCCCAGGAAGAGCGGGCAGAGTGGCCCAGCCCCAGGCAGTGCTTCCTGAGCAGACCACCCGGACTGTCTTTCCTCCACCCGCCCATGGAGAAAGAGCACGC
CCGGCCCCGCCCTGTGCTCACCTCTGCCTGGCTCAGCGACCTTCTCAGGCATTCTGCCCTCCTGGGCCCCTCTCTCCCTGAAGGGGCTTTGTGGCATCTCTGGAAGAGCAGGGTGTGCTGCACTCATGGGCCTGGTCTCACTCCTTGGAC
TTGTCACCTTGTGACATTTGGCTTATCAGCATTTGAGAAGGCTCTGCTGGGTCTCCATGGTGGGGGTCTCTCACCTTCTTGACCCTCTCTCCATCATTCAGCTGCCAGCCCAGGCTTCACACCCAAGCTGGCTCAGCAGCCGAGCCTGGC
ACCGAGGGTCCCTGCAGGCTCCCTGGGCAGGGAGAGGGCCAAGGACAATTGGGAGGGCAGCAGGCAGCCCGCAGATGGTGGCCATGTGGCACGCTGCTGAGACGACACTACCAATAAACCAAACTGCCACGC

>SLC9A8_TOM1L2_ENST00000541138_ENST00000379504_48431726_17754266 length=1056nt 
 Breakpoint=0nt
ATCCCCGTTGCGCAGCCATCTGTCATGGACGACATTGAGGTGTGGCTCAGGACCGACCTGAAGGGTGATGATCTGGAGGAGGGTGTCACAAGTGAAGAGTTTGATAAATTCCTTGAAGAAAGAGCCAAAGCTGCTGAAATGGTTCCCGAC
CTCCCCTCGCCCCCCATGGAGGCTCCTGCCCCAGCCTCAAACCCTTCTGGCCGGAAGAAGCCAGAGCGGTCAGAGGATGCCCTCTTCGCCCTGTGAGCAGCTCTGTGGTTTGCCTCCCCAGATGGCGGGTCCCCGCTCGCACCCCGTGGA
CACCGGGCACTGGCCACTCCTACATCCCCAGCTCCACACGGCCTGCACACCTGTGTTTCCATGGAAATGCCACCGTGTCTGCTCCCAGGCCTCCCACTAGTCAGGACCAGCTTCAGCCACTTCTTTTCTCTGAGTGGTGGGACAACTGCA
GCCAGAGACTCTCTCCCCTCCCACCATGGGCCCCTCTGCCCATGTTTCCTCCCAGGAAGAGCGGGCAGAGTGGCCCAGCCCCAGGCAGTGCTTCCTGAGCAGACCACCCGGACTGTCTTTCCTCCACCCGCCCATGGAGAAAGAGCACGC
CCGGCCCCGCCCTGTGCTCACCTCTGCCTGGCTCAGCGACCTTCTCAGGCATTCTGCCCTCCTGGGCCCCTCTCTCCCTGAAGGGGCTTTGTGGCATCTCTGGAAGAGCAGGGTGTGCTGCACTCATGGGCCTGGTCTCACTCCTTGGAC
TTGTCACCTTGTGACATTTGGCTTATCAGCATTTGAGAAGGCTCTGCTGGGTCTCCATGGTGGGGGTCTCTCACCTTCTTGACCCTCTCTCCATCATTCAGCTGCCAGCCCAGGCTTCACACCCAAGCTGGCTCAGCAGCCGAGCCTGGC
ACCGAGGGTCCCTGCAGGCTCCCTGGGCAGGGAGAGGGCCAAGGACAATTGGGAGGGCAGCAGGCAGCCCGCAGATGGTGGCCATGTGGCACGCTGCTGAGACGACACTACCAATAAACCAAACTGCCACGCACACACTGCAGGCTCACA
CCCGCA

>SLC9A8_TOM1L2_ENST00000541138_ENST00000395739_48431726_17754266 length=532nt 
 Breakpoint=0nt
ATCCCCGTTGCGCAGCCATCTGTCATGGACGACATTGAGGTGTGGCTCAGGACCGACCTGAAGGGTGATGATCTGGAGGAGGGTGTCACAAGTGAAGAGTTTGATAAATTCCTTGAAGAAAGAGCCAAAGCTGCTGAAATGGTTCCCGAC
CTCCCCTCGCCCCCCATGGAGGCTCCTGCCCCAGCCTCAAACCCTTCTGGCCGGAAGAAGCCAGAGCGGTCAGAGGATGCCCTCTTCGCCCTGTGAGCAGCTCTGTGGTTTGCCTCCCCAGATGGCGGGTCCCCGCTCGCACCCCGTGGA
CACCGGGCACTGGCCACTCCTACATCCCCAGCTCCACACGGCCTGCACACCTGTGTTTCCATGGAAATGCCACCGTGTCTGCTCCCAGGCCTCCCACTAGTCAGGACCAGCTTCAGCCACTTCTTTTCTCTGAGTGGTGGGACAACTGCA
GCCAGAGACTCTCTCCCCTCCCACCATGGGCCCCTCTGCCCATGTTTCCTCCCAGGAAGAGCGGGCAGAGTGGCCCAGCCCC

>SLC9A8_TOM1L2_ENST00000541138_ENST00000535933_48431726_17754266 length=435nt 
 Breakpoint=0nt
ATCCCCGTTGCGCAGCCATCTGTCATGGACGACATTGAGGTGTGGCTCAGGACCGACCTGAAGGGTGATGATCTGGAGGAGGGTGTCACAAGTGAAGAGTTTGATAAATTCCTTGAAGAAAGAGCCAAAGCTGCTGAAATGGTTCCCGAC
CTCCCCTCGCCCCCCATGGAGGCTCCTGCCCCAGCCTCAAACCCTTCTGGCCGGAAGAAGCCAGAGCGGTCAGAGGATGCCCTCTTCGCCCTGTGAGCAGCTCTGTGGTTTGCCTCCCCAGATGGCGGGTCCCCGCTCGCACCCCGTGGA
CACCGGGCACTGGCCACTCCTACATCCCCAGCTCCACACGGCCTGCACACCTGTGTTTCCATGGAAATGCCACCGTGTCTGCTCCCAGGCCTCCCACTAGTCAGGACCAGCTTCAGCCACTTCTTTTCTCTGAGT

>SLC9A8_TOM1L2_ENST00000541138_ENST00000581396_48431726_17754266 length=4367nt 
 Breakpoint=0nt
ATCCCCGTTGCGCAGCCATCTGTCATGGACGACATTGAGGTGTGGCTCAGGACCGACCTGAAGGGTGATGATCTGGAGGAGGGTGTCACAAGTGAAGAGTTTGATAAATTCCTTGAAGAAAGAGCCAAAGCTGCTGAAATGGTTCCCGAC
CTCCCCTCGCCCCCCATGGAGGCTCCTGCCCCAGCCTCAAACCCTTCTGGCCGGAAGAAGCCAGAGCGGTCAGAGGATGCCCTCTTCGCCCTGTGAGCAGCTCTGTGGTTTGCCTCCCCAGATGGCGGGTCCCCGCTCGCACCCCGTGGA
CACCGGGCACTGGCCACTCCTACATCCCCAGCTCCACACGGCCTGCACACCTGTGTTTCCATGGAAATGCCACCGTGTCTGCTCCCAGGCCTCCCACTAGTCAGGACCAGCTTCAGCCACTTCTTTTCTCTGAGTGGTGGGACAACTGCA
GCCAGAGACTCTCTCCCCTCCCACCATGGGCCCCTCTGCCCATGTTTCCTCCCAGGAAGAGCGGGCAGAGTGGCCCAGCCCCAGGCAGTGCTTCCTGAGCAGACCACCCGGACTGTCTTTCCTCCACCCGCCCATGGAGAAAGAGCACGC
CCGGCCCCGCCCTGTGCTCACCTCTGCCTGGCTCAGCGACCTTCTCAGGCATTCTGCCCTCCTGGGCCCCTCTCTCCCTGAAGGGGCTTTGTGGCATCTCTGGAAGAGCAGGGTGTGCTGCACTCATGGGCCTGGTCTCACTCCTTGGAC
TTGTCACCTTGTGACATTTGGCTTATCAGCATTTGAGAAGGCTCTGCTGGGTCTCCATGGTGGGGGTCTCTCACCTTCTTGACCCTCTCTCCATCATTCAGCTGCCAGCCCAGGCTTCACACCCAAGCTGGCTCAGCAGCCGAGCCTGGC
ACCGAGGGTCCCTGCAGGCTCCCTGGGCAGGGAGAGGGCCAAGGACAATTGGGAGGGCAGCAGGCAGCCCGCAGATGGTGGCCATGTGGCACGCTGCTGAGACGACACTACCAATAAACCAAACTGCCACGCACACACTGCAGGCTCACA
CCCGCACACCTGGTCCTGGCTTGTGGAGGGACTTGCACTGGAGGTATTGCTCTGGCTTGCCTGGGGAAGTGTCACAGATGTGCACATGGGCCACACTCAGTGCTGTGGCCTGGCCTGCCGTAGCCTCACACATCTGCCTCAAGAGCCAGC
AGCAAACAGCTTTGTGGCATCCTTGGAGGTTCCCAGTGACTGAGAGGCCTGGGCAGCACTAAGGCCCCTGCTCTGCTCCCTGGCATAGGCCTTGGCCTCCTTGCACAGACTCTCCTGACAGTCTGGCCTCCTCCCACCTCAGAGGTCCTC
TGGCCACCAATTTATACTCTCTCCCCAAGCTGATCCTGAAGGCAGGCAGAGCAGCTAGGGGCTGGTAACATGTATTCCCATCCCGTGTCCTCACTGGTGTGTCTCCTGGCCATGGGCAAGGGACTCGGGTCATCCCAGGCCCTGGTCCAG
CCAGACACCTGGCCCCACACCTCCCACCAGGCTGCTGTTGCTCAGAAGGAGAATACTGCAGCTGTATGCATCCCCGTGTGTCTTGGGCCCAGCTCGCTGGGTCAGTCTGCTCCTGTCCCCTCCAGCATGCACTGCCTAGGTCAGCACAGG
TTCCTGATCCATGGTGTAGTTAGCCCTTCCCACCTGGCAGGACGGCCCAGACCACCAGCCAAGCAGGGAAAGGGGGCTGGGCTTGACGGGAGAAGAGACCAGCGACATGGTCGTTGGGGAGCATTCAGGATGGCGACTTCAGCTGGGGGT
CATGCTGAGCACCAACAGGAACTATTCCAGTGAAGAGCAAGTGCTGCCCGACCCAGGACCCTGTGCCAGGCTAGCAGCCCTCCAGCTCCCTCCAGAGAGGAAACCTCTGTCTGGCTGAGGGTGGGACTAGCTGGGATGTCTCACTCCAGT
TGCTCAGGTTCACCCAGGAAGCTCCTCCGTGGAGTGGCCAGCCTGATTCTAGCCCTGTCCTCTCTGGCAGCACATGCCACACCTGCCTGGGCCTTCTGCTCCCTGATGCTTGATGAGCCCCTGCCTCCTCAATGTTTCTCAAAGACAGAC
CCCCCTGAGGCCAGCTTGAATGTGAAGACTGCTGAAGTTAGCTGGCTTCACTTGAGCTGCAGAAAAGGTGGCTGGGATGGCCCAGGTGCACCCAGAGGCCCCAGCCCTTTGGCTGCCTTTGGGTTGTGACTTGGGTTGTCTCTGAGGCCC
TGCCAGAGCTGGGCCTGCGGGTGGTGGGCGGTCCGACCTCGGGCAGTCAGTGCTCCGCAGCCTCAGCACTGCATCCCAGACCCAGTGTCCTCAGAGGGAAGAGCCAGCCTCCCTGCCTCATGGAACCAGGAGTCCCAAAAAGTCAGGAGC
CTGGAGGCTCTGAAAGGAGCAGGGATTCCATAGTGCGTGAAGCTGAAATAGGCGCCCTCCTGGGGAGCCCCCAGCAAAACTGTTTTTCATACCCACTCCCAGAACTGCCCCGCTCCAGCTCCAGCGCCAGCGCCAGCTGGTTGCCAGGCA
TCATTGGAGAGGCCTGGCTGCCCCAGGGGCAGCAGGGAGTGGTGGACCTGTATGGGCTGGCAGGAGGCCATTGGCCATGCTGACAAGTGTCACCTGCCTTCCTAGCCTGGAGCCACCCCTCAGGTGGCCTGCTTGCACCTCCTATCCGGA
GGTAGCCTGCCCCACCTGTAGGCAGAGGGGGCTCTTGCTTGAGGCCTGCACAGGAAGCAAGTATAGCCCCGGTGCCCCAGAGTGGGTTCCACTTAGCCCTGGCGAGATGGCCTGTCCTGAGATCTCTGCTCCCAGACCCCACCATCTGGG
GAGCACAGTCCTTAGGCTGCCTGGTCCAGGAAGGGGGTGCGGCTCTGTCAGGAAACCTGGACTCTCAAGGCCCACCAGCCTCTCCGTGAGTGTTAGAAATCACAGATACAGTATATACTTAATTACACTAAATTATTGCTGGGATTCCTT
ATAAGCACTAATTATACCTGATTATAGGTTAAAATATTTATTTTGTCAAAATATTTTCTTGGGAATGTGTTTAACCCTTTCTGCGTTCATTGTTGCTGAGATGTGAAAACTAACCATTCCCTCCTGCCTACCTTTTTGGCCACTGGGCGG
CAGAGAATGGCGCTATGTGCAGTTGGGCCCCTGGCACCATGGGCCTTTGGCCTGCCTGCTGCAGAGTAGCCCTGCCTGGGCAGTCTCCAGGCACTGAGCAGGCCATCTGTGGCCAGGCTGAGAGAATGACTGGCTCGCTTACCAGCGTGC
ATGGGACAAGGAGCTTTGGAGCCTCAAGGGGTTGTTGCTGGCCTGGGCTAGAGGGAAAGGTGACCATCCGTCTGTCCTCCTGTCTTTCTATTAGCGCCTCCATGTGAGTGATGGTGCCTTGGTTCACTAGCCTTCCCCCACCACCCCACC
ATGCCACCTGGTGGTCTTGGGGCCTGTGCTGTCACTCCAGCCCCTGGGGAGGAGAGGACCCAGCCCGGAGAGTTGGGGCAAGGGCTCCACATGGCCCAAGGGCAACAGATGCTCGCAGGGCAGCTGCTGCCGATGCTCACGCTCCTGCCC
CCCTCCTTCCCGCTGCCACACCCCACCCTGGGCCCCCGCAGACACGCATCTCTAACTCAGTTGGGCCCAGCCTTCTGGATGGCTTGGGGTAGGCCATGGGCCCACCTGGGGCCAGGCCAGCCCCTGGGGCAGCTCTGGAAGAGCAGTGTG
GAGGAGCACTTGCTTGCAGCCTGGCTTCAGCCTCTGGCACTGCTGGAGTGGTCCCTGGGAGCTTCTGCACTGTCGGCTTTGGGGACGTCTCACCCACTTGGGTTACAGTAGGCCTTCCCCACCCAGAGAGAAGTGTTTCCACCCCAGAGA
CATTGTCTGTCAGCCCCTGAAGTGCTCGCCTCCCCCAGTGCCCGTCACCAGCCCTTCCTATCTGTGGGGTCCAAGTCAGGCTTCCCCTGCGGCCACCAGCCATAGGGAGCAGCCATCAGCCCCCGAGTCAGAACTGCTTCTGTCTGTCCA
TACCTCCAGGCTCTCCCGGAGAGGGGGACGGATATTTATTTCCTAAAGTTTGCACTTAATTGTGAGGATTCTCAGGATTGTTGGGGGCTACTGAAAAGAGGAATGTGTTGAATGTCGCGTTTGCTGTCCACTCGTCCTAGAAGTTTAGTG
TTTTTGTCACTGTCATGTGTTTCTGTGGGCAGAGCTGGTTCTGGAGGGTGGGTCAGTGCACCCGAGGCTCAGAGCATCCATCCACCCCACTGGCCCTCCTTCCAGATACCCTCTCTCTAATTGGGTTCTTGCATGTAAAATACTCCACAA
TAAATAAATAATTGAAC

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for SLC9A8_TOM1L2

In-frame Fusion Protein Sequences.

N-Truncated Protein (5UTR-3CDS) Sequences

>SLC9A8_TOM1L2_ENST00000539601_ENST00000318094_48431726_17754266 length=129nt
MNVPEASLFSEQHWGLGASLGLSLQAPPGFPERRCDWQEAGYPQGNPSSRLGDPHCRLLLNSAGNQSWQPPVGGQSRFPWQPSAASSWLGREGSKPAEIAMEGLAQAATLVCWAKTLMTPPFQIRLGCH

>SLC9A8_TOM1L2_ENST00000539601_ENST00000379504_48431726_17754266 length=344nt
MMQAQGILIRDNVRTIGAQVYEQVLRSAYAKRNSSVNDSDYPLDLNHSETFLQTTTFLPEDFTYFANHTCPERLPSMKGPIDINMSEIGMDYIHELFSKDPTIKLGGHWKPSDCMPRWKVAILIPFRNRHEHLPVLFRHLLPMLQRQRLQ
FAFYVVEQVGTQPFNRAMLFNVGFQEAMKDLDWDCLIFHDVDHIPESDRNYYGCGQMPRHFATKLDKYMYLLPYTEFFGGVSGLTVEQFRKINGFPNAFWGWGGEDDDLWNRVQNAGYSVSRPEGDTGKYKSIPHHHRGEVQFLGRYALL
RKSKERQGLDGLNNLNYFANITYDALYKNITVNLTPELAQVNEY

>SLC9A8_TOM1L2_ENST00000539601_ENST00000395739_48431726_17754266 length=172nt
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRAAHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRS
SPFRSVLSHTSMSSMTDGCATG

>SLC9A8_TOM1L2_ENST00000539601_ENST00000535933_48431726_17754266 length=110nt
MIWRRVSQVKSLINSLKKEPKLLKWFPTSPRPPWRLLPQPQTLLAGRSQSGQRMPSSPCEQLCGLPPQMAGPRSHPVDTGHWPLLHPQLHTACTPVFPWKCHRVCSQASH

>SLC9A8_TOM1L2_ENST00000539601_ENST00000581396_48431726_17754266 length=138nt
MKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRAAHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRSSPFRSVLSHTSMSSMTDGCATG

>SLC9A8_TOM1L2_ENST00000541138_ENST00000318094_48431726_17754266 length=129nt
MNVPEASLFSEQHWGLGASLGLSLQAPPGFPERRCDWQEAGYPQGNPSSRLGDPHCRLLLNSAGNQSWQPPVGGQSRFPWQPSAASSWLGREGSKPAEIAMEGLAQAATLVCWAKTLMTPPFQIRLGCH

>SLC9A8_TOM1L2_ENST00000541138_ENST00000379504_48431726_17754266 length=344nt
MMQAQGILIRDNVRTIGAQVYEQVLRSAYAKRNSSVNDSDYPLDLNHSETFLQTTTFLPEDFTYFANHTCPERLPSMKGPIDINMSEIGMDYIHELFSKDPTIKLGGHWKPSDCMPRWKVAILIPFRNRHEHLPVLFRHLLPMLQRQRLQ
FAFYVVEQVGTQPFNRAMLFNVGFQEAMKDLDWDCLIFHDVDHIPESDRNYYGCGQMPRHFATKLDKYMYLLPYTEFFGGVSGLTVEQFRKINGFPNAFWGWGGEDDDLWNRVQNAGYSVSRPEGDTGKYKSIPHHHRGEVQFLGRYALL
RKSKERQGLDGLNNLNYFANITYDALYKNITVNLTPELAQVNEY

>SLC9A8_TOM1L2_ENST00000541138_ENST00000395739_48431726_17754266 length=172nt
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRAAHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRS
SPFRSVLSHTSMSSMTDGCATG

>SLC9A8_TOM1L2_ENST00000541138_ENST00000535933_48431726_17754266 length=110nt
MIWRRVSQVKSLINSLKKEPKLLKWFPTSPRPPWRLLPQPQTLLAGRSQSGQRMPSSPCEQLCGLPPQMAGPRSHPVDTGHWPLLHPQLHTACTPVFPWKCHRVCSQASH

>SLC9A8_TOM1L2_ENST00000541138_ENST00000581396_48431726_17754266 length=138nt
MKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRAAHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRSSPFRSVLSHTSMSSMTDGCATG

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for SLC9A8_TOM1L2

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for SLC9A8_TOM1L2

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		BLCA	TCGA-4Z-AA7R-01A	SLC9A8	chr20	48431726	-	TOM1L2	chr17	17754266	-
ChimerDB		BLCA	TCGA-4Z-AA7R-01A	SLC9A8	chr20	48431726	+	TOM1L2	chr17	17754266	-
cBioPortal	BLCA_TCGA_PAN_CAN_ATLAS_2018	BLCA	TCGA-4Z-AA7R-01	SLC9A8	chr20	49815189		TOM1L2	chr17	17850952

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for SLC9A8_TOM1L2

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status