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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:ADNP_SCCPDH (FusionGDB2 ID:HG23394TG51097)

Fusion Gene Summary for ADNP_SCCPDH

Fusion gene summary

Fusion gene information	Fusion gene name: ADNP_SCCPDH
	Fusion gene ID: hg23394tg51097
		Hgene	Tgene
	Gene symbol	ADNP	SCCPDH
	Gene ID	23394	51097
	Gene name	activity dependent neuroprotector homeobox	saccharopine dehydrogenase (putative)
	Synonyms	ADNP1\|HVDAS\|MRD28	CGI-49\|NET11
	Cytomap	20q13.13	1q44
	Type of gene	protein-coding	protein-coding
	Description	activity-dependent neuroprotector homeobox proteinADNP homeobox 1activity-dependent neuroprotective proteinactivity-dependent neuroprotector	saccharopine dehydrogenase-like oxidoreductaseepididymis secretory sperm binding proteinprobable saccharopine dehydrogenase
	Modification date	20240403	20240305
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000349014, ENST00000396032, ENST00000371602, ENST00000396029,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 22 X 12 X 15=3960	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 6 X 19 X 8=912
	# samples	40	18
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(40/396010)=-3.30742852519225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(18/91210)=-2.34103691783507 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ADNP [Title/Abstract] AND SCCPDH [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ADNP(49518553)-SCCPDH(246899276), # samples:1

Fusion gene breakpoints across ADNP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SCCPDH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for ADNP_SCCPDH

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ADNP	chr20	49518553	SCCPDH	chr1	49518553
ADNP	chr20	49518554	SCCPDH	chr1	246899277
ADNP	chr20	50902017	SCCPDH	chr1	246735975

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for ADNP_SCCPDH

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
ADNP-SCCPDH	Promoter / Enhancer Hijacking M6		Promoter swap alters saccharopine dehydrogenase-like oxidoreductase expression, modulating lysine catabolism and mitochondrial redox.		Metabolic pathway inhibitors		Solid tumors

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
ADNP-SCCPDH	Promoter / Enhancer Hijacking M6		Promoter swap alters saccharopine dehydrogenase-like oxidoreductase expression, modulating lysine catabolism and mitochondrial redox.		Metabolic pathway inhibitors		Solid tumors	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 29939481; Title: Cell- and Tissue-Based Proteome Profiling and Bioimaging with Probes Derived from a Potent AXL Kinase Inhibitor.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

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Fusion Genomic Features for ADNP_SCCPDH

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ADNP	chr20	49518553	-	SCCPDH	chr1	246899276	+	7.54e-04	9.99e-01

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for ADNP_SCCPDH

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000349014	ENST00000366510	ADNP	chr20	49518553	-	SCCPDH	chr1	246899276	+
Frame-shift	ENST00000396032	ENST00000366510	ADNP	chr20	49518553	-	SCCPDH	chr1	246899276	+
In-frame	ENST00000371602	ENST00000366510	ADNP	chr20	49518553	-	SCCPDH	chr1	246899276	+
In-frame	ENST00000396029	ENST00000366510	ADNP	chr20	49518553	-	SCCPDH	chr1	246899276	+

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000371602	ENST00000366510	ADNP	chr20	49518553	SCCPDH	chr1	246899276	521	421
ENST00000396029	ENST00000366510	ADNP	chr20	49518553	SCCPDH	chr1	246899276	769	165

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000371602	ENST00000366510	ADNP	chr20	49518553	SCCPDH	chr1	246899276	2.12e-03	9.98e-01
ENST00000396029	ENST00000366510	ADNP	chr20	49518553	SCCPDH	chr1	246899276	1.84e-03	9.98e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for ADNP_SCCPDH

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

ADNP_SCCPDH_chr20-49518553_chr1-246899276.png

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ADNP

chr20:49518553

chr1:246899276

ENST00000371602

Q9H2P0

1058_1069

67.0

1103.0

Compositional bias

Polar residues

Hgene

ADNP

chr20:49518553

chr1:246899276

ENST00000371602

Q9H2P0

393_433

67.0

1103.0

Compositional bias

Low complexity

Hgene

ADNP

chr20:49518553

chr1:246899276

ENST00000371602

Q9H2P0

692_711

67.0

1103.0

Compositional bias

Polar residues

Hgene

ADNP

chr20:49518553

chr1:246899276

ENST00000371602

Q9H2P0

851_873

67.0

1103.0

Compositional bias

Basic and acidic residues

Hgene

ADNP

chr20:49518553

chr1:246899276

ENST00000371602

Q9H2P0

899_947

67.0

1103.0

Compositional bias

Basic and acidic residues

Hgene

ADNP

chr20:49518553

chr1:246899276

ENST00000371602

Q9H2P0

971_982

67.0

1103.0

Compositional bias

Polar residues

Hgene

ADNP

chr20:49518553

chr1:246899276

ENST00000371602

Q9H2P0

754_814

67.0

1103.0

DNA binding

Homeobox

Hgene

ADNP

chr20:49518553

chr1:246899276

ENST00000371602

Q9H2P0

1043_1102

67.0

1103.0

Region

Disordered

Hgene

ADNP

chr20:49518553

chr1:246899276

ENST00000371602

Q9H2P0

354_361

67.0

1103.0

Region

Neuroprotective peptide (NAP)

Hgene

ADNP

chr20:49518553

chr1:246899276

ENST00000371602

Q9H2P0

354_443

67.0

1103.0

Region

Disordered

Hgene

ADNP

chr20:49518553

chr1:246899276

ENST00000371602

Q9H2P0

691_712

67.0

1103.0

Region

Disordered

Hgene

ADNP

chr20:49518553

chr1:246899276

ENST00000371602

Q9H2P0

851_1030

67.0

1103.0

Region

Disordered

Hgene

ADNP

chr20:49518553

chr1:246899276

ENST00000371602

Q9H2P0

107_129

67.0

1103.0

Zinc finger

C2H2-type 2%3B atypical

Hgene

ADNP

chr20:49518553

chr1:246899276

ENST00000371602

Q9H2P0

165_188

67.0

1103.0

Zinc finger

C2H2-type 3

Hgene

ADNP

chr20:49518553

chr1:246899276

ENST00000371602

Q9H2P0

221_244

67.0

1103.0

Zinc finger

C2H2-type 4

Hgene

ADNP

chr20:49518553

chr1:246899276

ENST00000371602

Q9H2P0

447_469

67.0

1103.0

Zinc finger

C2H2-type 5%3B atypical

Hgene

ADNP

chr20:49518553

chr1:246899276

ENST00000371602

Q9H2P0

489_510

67.0

1103.0

Zinc finger

C2H2-type 6%3B atypical

Hgene

ADNP

chr20:49518553

chr1:246899276

ENST00000371602

Q9H2P0

512_535

67.0

1103.0

Zinc finger

C2H2-type 7

Hgene

ADNP

chr20:49518553

chr1:246899276

ENST00000371602

Q9H2P0

622_647

67.0

1103.0

Zinc finger

C2H2-type 8%3B atypical

Hgene

ADNP

chr20:49518553

chr1:246899276

ENST00000371602

Q9H2P0

662_686

67.0

1103.0

Zinc finger

C2H2-type 9%3B atypical

Hgene

ADNP

chr20:49518553

chr1:246899276

ENST00000371602

Q9H2P0

74_97

67.0

1103.0

Zinc finger

C2H2-type 1

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for ADNP_SCCPDH

In-frame Fusion Transcript Sequences.

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276 length=2345nt 
 Breakpoint=521nt
TTGAGCCCAGAAGGTTGAGGCTATGGTGAATCGTGAGTGCACTGCAGTCAATGAACCATGAGTGCACTGCACTCCAGCCTGCGCGACAGAGTAAGACTCTGTCTTAAGAAAAGGAAGGAAGGATGGATGGATGGATATATCAAGCCATAT
GCACATGAAAGCAGGTGTGTGTCTGTGTGTGTACACACTAGATGAGGATATCTATGCACCTTTTTTGTCAGATGGGTAGGTTTTATGATCCTATCATCAGTGGAATTAGTAAATATTACAAGTTGTACGTGTTTTGACTTTGACTTAAAT
TTTTTTTTCCAATAGAAACTATGTTCCAACTTCCTGTCAACAATCTTGGCAGTTTAAGAAAAGCCCGGAAAACTGTGAAAAAAATACTTAGTGACATTGGGTTGGAATACTGTAAAGAACATATAGAAGATTTTAAACAATTTGAACCTA
ATGACTTTTATTTGAAAAACACTACATGGGAGGATGTAGGACTGTGGGACCCATCACTTACGAAAAACCAGTATCGGTTTTATGGAGAACCTGTAATAAAAGCATGTATTGAAAATGGAGCCAGTTGTATCGACATCAGTGGAGAACCTC
AGTTTCTGGAACTAATGCAACTGAAGTATCATGAGAAAGCTGCAGACAAAGGGGTTTATATCATTGGAAGCAGCGGCTTTGACTCCATTCCAGCAGATCTGGGAGTAATATATACCAGAAATAAAATGAATGGTACTTTGACTGCTGTGG
AAAGTTTCCTGACTATACATTCAGGACCTGAGGGGTTGAGCATTCATGATGGTACCTGGAAGTCAGCAATTTATGGTTTTGGAGATCAGAGTAATTTGAGAAAACTAAGAAATGTATCAAATCTGAAACCTGTCCCGCTCATTGGTCCAA
AATTGAAGAGAAGGTGGCCAATTTCTTATTGTCGGGAACTCAAAGGTTATTCCATTCCTTTTATGGGATCTGATGTGTCTGTTGTAAGGAGGACTCAACGTTACTTGTATGAAAATTTAGAGGAATCACCAGTTCAGTATGCTGCGTATG
TAACTGTGGGAGGCATCACCTCTGTTATTAAGCTGATGTTTGCAGGACTTTTCTTTTTGTTCTTTGTGAGGTTTGGAATTGGAAGGCAACTTCTCATAAAATTCCCATGGTTCTTCTCCTTTGGCTATTTTTCAAAACAAGGCCCAACAC
AAAAACAGATTGATGCTGCCTCATTCACGCTGACATTCTTTGGTCAAGGATACAGCCAAGGCACTGGTACAGATAAGAACAAACCAAATATCAAAATTTGTACTCAGGTGAAAGGACCAGAGGCTGGCTATGTGGCTACCCCCATAGCTA
TGGTTCAGGCAGCCATGACTCTTCTAAGTGATGCTTCTCATCTGCCTAAGGCGGGCGGGGTCTTCACACCTGGAGCAGCTTTTTCCAAAACAAAGTTGATTGACAGACTCAACAAACACGGTATTGAGTTTAGTGTTATTAGCAGCTCTG
AAGTCTAAACACTGGAAGAATTAACTGAAGTCATAACGTGCGTGAATTAACAGCTTCTCTATTTGATATTTGAAATTCTTCTGTAAGCCTGTCTGAGTGTATGTGGAAACGATTGTCAAATCTAAAATATCTATATATTAAAAAGTAGGA
AATTGTCCTAGCTTACCCTAAATTTCAAATCTGAGTTGATTTTGTGATTTTATTGCTTATAACAGAGAACTCATATTTGACATATTTTTTTCATTGATGTGTTCCTGGTAGATTTTCACGAATGAGCTGGCAGGTCTAATGGGGGAGGCG
GCGTCCCAGTCTGTGTTGCAGCAGCATTCTCATCGGGGGTGCGCACACCATCGTTACTGTCGGGCAGTAACTGCCGCTTGCCTTGCCGCAGTAGGAGGGAAATCTCACCTTCCTTCCACATACTGTCTTGAGCCTTTGCTAAATTAAACT
GCACTTTTTGCTATTTTTGCCTAGTTTTTCGCCAATCTACACTGATTTTGGACTGTTACCTAAGTTGAAAAATAAAAGGTTGTCAATCGAATGGTGGTTTAATGTTTGGACCTGCCGATGTATTTGTATAGTGGTAGAAACATGCTGCTT
AAGTGGCCTAACCTGTTTCTTGCCAATAAGTAGGCTTATCATTTTATCTTTACGTAATTCTATATCTGTGACTAGGTTTTTAAGGATACAGCTTATAAGTTGCTATCAATTTTCACTACCTAAGCAGAATTTTTCTCTAATTTACTTTTT
GTATTTTAACTAGGTTTTACATGGAAGCCCTAAAATAAGGCAAAAGACTTTTTCTTTTGTAATAAGCATATAATAAACACGTATATACATAGCAA

>ADNP_SCCPDH_ENST00000396029_ENST00000366510_49518553_246899276 length=2593nt 
 Breakpoint=769nt
GCAGCGCTAAGGGGGATTTTGGCGTCTTCTCAGACACAGCTCCCTCTCTCGGTCCCCGCTGCTGAGGAGCGAGAGGAGCGCGGCCGCCGCCGCCCGCGCCGGTGAAGCCGCCTCTCCCACACCCTCCGTCTCCTCCCTCCGCCCCTCCTT
TGTCTGCACCGCTCGACGACGCCGCCGCCGCCCGCCGCTCTGCTGCGCCCGCCGCGCCCCCCGGCAGCACCCGCGGCCGCGGCGCGAGCCGGAGTCCGCCGAGCCGGAGCGCGACGAGGCCCCGGGCGCGCCCTCCCCGCTGCCGCCACC
GCCGTGCCGCCGCCATCCGCCCGCCGCCGCCGCCGCTGTCCGGCCCCCGAGCACGCCGGCCCCGCGCGCGCCTCGAGGCCGAGTCAAGGTGTGAGATGCACAATGCGAAACCTAGGCCCCAGCTTTTACACCATGATGCGCAGGGTTGTA
CTTTTTGTACTGAACTGATAGGTGGCCTAGTGGTTATGCCCTGTACTACCATTTTGAGGATCTGGACTCCGTTTCCTGCCTTGCTCTTTGGACCACATTGTCAATTCACACCGAAACTATGTTCCAACTTCCTGTCAACAATCTTGGCAG
TTTAAGAAAAGCCCGGAAAACTGTGAAAAAAATACTTAGTGACATTGGGTTGGAATACTGTAAAGAACATATAGAAGATTTTAAACAATTTGAACCTAATGACTTTTATTTGAAAAACACTACATGGGAGGATGTAGGACTGTGGGACCC
ATCACTTACGAAAAACCAGTATCGGTTTTATGGAGAACCTGTAATAAAAGCATGTATTGAAAATGGAGCCAGTTGTATCGACATCAGTGGAGAACCTCAGTTTCTGGAACTAATGCAACTGAAGTATCATGAGAAAGCTGCAGACAAAGG
GGTTTATATCATTGGAAGCAGCGGCTTTGACTCCATTCCAGCAGATCTGGGAGTAATATATACCAGAAATAAAATGAATGGTACTTTGACTGCTGTGGAAAGTTTCCTGACTATACATTCAGGACCTGAGGGGTTGAGCATTCATGATGG
TACCTGGAAGTCAGCAATTTATGGTTTTGGAGATCAGAGTAATTTGAGAAAACTAAGAAATGTATCAAATCTGAAACCTGTCCCGCTCATTGGTCCAAAATTGAAGAGAAGGTGGCCAATTTCTTATTGTCGGGAACTCAAAGGTTATTC
CATTCCTTTTATGGGATCTGATGTGTCTGTTGTAAGGAGGACTCAACGTTACTTGTATGAAAATTTAGAGGAATCACCAGTTCAGTATGCTGCGTATGTAACTGTGGGAGGCATCACCTCTGTTATTAAGCTGATGTTTGCAGGACTTTT
CTTTTTGTTCTTTGTGAGGTTTGGAATTGGAAGGCAACTTCTCATAAAATTCCCATGGTTCTTCTCCTTTGGCTATTTTTCAAAACAAGGCCCAACACAAAAACAGATTGATGCTGCCTCATTCACGCTGACATTCTTTGGTCAAGGATA
CAGCCAAGGCACTGGTACAGATAAGAACAAACCAAATATCAAAATTTGTACTCAGGTGAAAGGACCAGAGGCTGGCTATGTGGCTACCCCCATAGCTATGGTTCAGGCAGCCATGACTCTTCTAAGTGATGCTTCTCATCTGCCTAAGGC
GGGCGGGGTCTTCACACCTGGAGCAGCTTTTTCCAAAACAAAGTTGATTGACAGACTCAACAAACACGGTATTGAGTTTAGTGTTATTAGCAGCTCTGAAGTCTAAACACTGGAAGAATTAACTGAAGTCATAACGTGCGTGAATTAACA
GCTTCTCTATTTGATATTTGAAATTCTTCTGTAAGCCTGTCTGAGTGTATGTGGAAACGATTGTCAAATCTAAAATATCTATATATTAAAAAGTAGGAAATTGTCCTAGCTTACCCTAAATTTCAAATCTGAGTTGATTTTGTGATTTTA
TTGCTTATAACAGAGAACTCATATTTGACATATTTTTTTCATTGATGTGTTCCTGGTAGATTTTCACGAATGAGCTGGCAGGTCTAATGGGGGAGGCGGCGTCCCAGTCTGTGTTGCAGCAGCATTCTCATCGGGGGTGCGCACACCATC
GTTACTGTCGGGCAGTAACTGCCGCTTGCCTTGCCGCAGTAGGAGGGAAATCTCACCTTCCTTCCACATACTGTCTTGAGCCTTTGCTAAATTAAACTGCACTTTTTGCTATTTTTGCCTAGTTTTTCGCCAATCTACACTGATTTTGGA
CTGTTACCTAAGTTGAAAAATAAAAGGTTGTCAATCGAATGGTGGTTTAATGTTTGGACCTGCCGATGTATTTGTATAGTGGTAGAAACATGCTGCTTAAGTGGCCTAACCTGTTTCTTGCCAATAAGTAGGCTTATCATTTTATCTTTA
CGTAATTCTATATCTGTGACTAGGTTTTTAAGGATACAGCTTATAAGTTGCTATCAATTTTCACTACCTAAGCAGAATTTTTCTCTAATTTACTTTTTGTATTTTAACTAGGTTTTACATGGAAGCCCTAAAATAAGGCAAAAGACTTTT
TCTTTTGTAATAAGCATATAATAAACACGTATATACATAGCAA

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for ADNP_SCCPDH

In-frame Fusion Protein Sequences.

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276 length=421nt
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000396029_ENST00000366510_49518553_246899276 length=165nt
MHRSTTPPPPAALLRPPRPPAAPAAAARAGVRRAGARRGPGRALPAAATAVPPPSARRRRRCPAPEHAGPARASRPSQETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQITP
ISTRAGTTGSLTTRN

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for ADNP_SCCPDH

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_5-gene_p.T64R_421_T90R length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLRKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.P247L_421_P239L length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSILFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.P247S_421_P239S length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSISFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.K353M_421_K345M length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDMNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.M290K_421_M282K length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLKFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.A381E_421_A373E length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQEAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.I358S_421_I350S length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNSKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.P247A_421_P239A length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIAFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.D332N_421_D324N length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQINAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.E268Q_421_E260Q length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLQESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.K288N_421_K280N length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVINLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.D122Y_421_D114Y length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIYISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.G195S_421_G187S length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDSTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_both_p.N8D;p.T51N-p.G203D;p.S245Y_421_N34D;T77N;G195D;S237Y length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNDLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNNTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYDFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYYIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.L410F_421_L402F length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKFIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.G250R_421_G242R length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMRSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.R239Q_421_R231Q length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCQELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.P247A_421_P239A length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIAFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.A112S_421_A104S length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKSCIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.S254Y_421_S246Y length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVYVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.R211I_421_R203I length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLIKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.E265D_421_E257D length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYDNLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.F180L_421_F172L length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESLLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.R301W_421_R293W length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVWFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.D143Y_421_D135Y length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAAYKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.Q347R_421_Q339R length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSRGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.I310L_421_I302L length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LLKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.T182I_421_T174I length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLIIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.G342S_421_G334S length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFSQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.I376V_421_I368V length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPVAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.R306G_421_R298G length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGGQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.I310L_421_I302L length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LLKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.S152I_421_S144I length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSIGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.S156Y_421_S148Y length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDYIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.G189W_421_G181W length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEWLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.P223L_421_P215L length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVLLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.F299L_421_F291L length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFLVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.E115K_421_E107K length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIKNGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.F421L_421_F413L length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIELSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.E131K_421_E123K length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLKLMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.L289P_421_L281P length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKPMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.F129Y_421_F121Y length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQYLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.R239Q_421_R231Q length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCQELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.N171S_421_N163S length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMSGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.M383T_421_M375T length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAATTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_5-gene_p.I22K;p.L23I_421_I48K;L49I length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKKISDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.R103P_421_R95P length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYPFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_5-gene_p.H34N_421_H60N length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKENIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.E368D_421_E360D length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPDAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.E115K_421_E107K length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIKNGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_3-gene_p.G325D_421_G317D length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQDPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000371602_ENST00000366510_49518553_246899276_5-gene_p.E54K_421_E80K length=421AA
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWKDVGLWDPSLTKNQYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIP
ADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQL
LIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

>ADNP_SCCPDH_ENST00000396029_ENST00000366510_49518553_246899276_5-gene_p.T64R_165_T144R length=165AA
MHRSTTPPPPAALLRPPRPPAAPAAAARAGVRRAGARRGPGRALPAAATAVPPPSARRRRRCPAPEHAGPARASRPSQETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLRKNQITP
ISTRAGTTGSLTTRN

>ADNP_SCCPDH_ENST00000396029_ENST00000366510_49518553_246899276_5-gene_p.N8D;p.T51N_165_N88D;T131N length=165AA
MHRSTTPPPPAALLRPPRPPAAPAAAARAGVRRAGARRGPGRALPAAATAVPPPSARRRRRCPAPEHAGPARASRPSQETMFQLPVNDLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNNTWEDVGLWDPSLTKNQITP
ISTRAGTTGSLTTRN

>ADNP_SCCPDH_ENST00000396029_ENST00000366510_49518553_246899276_5-gene_p.I22K;p.L23I_165_I102K;L103I length=165AA
MHRSTTPPPPAALLRPPRPPAAPAAAARAGVRRAGARRGPGRALPAAATAVPPPSARRRRRCPAPEHAGPARASRPSQETMFQLPVNNLGSLRKARKTVKKKISDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQITP
ISTRAGTTGSLTTRN

>ADNP_SCCPDH_ENST00000396029_ENST00000366510_49518553_246899276_5-gene_p.H34N_165_H114N length=165AA
MHRSTTPPPPAALLRPPRPPAAPAAAARAGVRRAGARRGPGRALPAAATAVPPPSARRRRRCPAPEHAGPARASRPSQETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKENIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQITP
ISTRAGTTGSLTTRN

>ADNP_SCCPDH_ENST00000396029_ENST00000366510_49518553_246899276_5-gene_p.E54K_165_E134K length=165AA
MHRSTTPPPPAALLRPPRPPAAPAAAARAGVRRAGARRGPGRALPAAATAVPPPSARRRRRCPAPEHAGPARASRPSQETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWKDVGLWDPSLTKNQITP
ISTRAGTTGSLTTRN

Fusion Protein ID	Sample ID	Mutated Partner	AAchange in WT	Seq. Length	AAchange in Fusion
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-17-Z001-01A	5-gene	p.T64R	421	T90R
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-18-3409-01A	3-gene	p.P247L	421	P239L
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-21-1079-01A	3-gene	p.P247S	421	P239S
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-2G-AAFO-01A	3-gene	p.K353M	421	K345M
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-33-4547-01A	3-gene	p.M290K	421	M282K
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-33-4566-01A	3-gene	p.A381E	421	A373E
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-3N-A9WC-06A	3-gene	p.I358S	421	I350S
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-49-6742-01A	3-gene	p.P247A	421	P239A
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-50-5941-01A	3-gene	p.D332N	421	D324N
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-58-8393-01A	3-gene	p.E268Q	421	E260Q
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-85-8354-01A	3-gene	p.K288N	421	K280N
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-96-A4JK-01A	3-gene	p.D122Y	421	D114Y
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-98-8022-01A	3-gene	p.G195S	421	G187S
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-A5-A0G2-01A	both	p.N8D;p.T51N-p.G203D;p.S245Y	421	N34D;T77N;G195D;S237Y
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-A8-A07B-01A	3-gene	p.L410F	421	L402F
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-AJ-A3EK-01A	3-gene	p.G250R	421	G242R
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-AJ-A3OJ-01A	3-gene	p.R239Q	421	R231Q
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-AO-A03M-01B	3-gene	p.P247A	421	P239A
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-AP-A051-01A	3-gene	p.A112S	421	A104S
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-AX-A2HC-01A	3-gene	p.S254Y	421	S246Y
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-B5-A0JY-01A	3-gene	p.R211I	421	R203I
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-B5-A3FA-01A	3-gene	p.E265D	421	E257D
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-B5-A5OC-01A	3-gene	p.F180L	421	F172L
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-BP-4988-01A	3-gene	p.R301W	421	R293W
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-BR-8081-01A	3-gene	p.D143Y	421	D135Y
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-BR-8487-01A	3-gene	p.Q347R	421	Q339R
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-CC-5263-01A	3-gene	p.I310L	421	I302L
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-CM-5348-01A	3-gene	p.T182I	421	T174I
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-CV-7406-01A	3-gene	p.G342S	421	G334S
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-CV-A6K1-01A	3-gene	p.I376V	421	I368V
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-D1-A17U-01A	3-gene	p.R306G	421	R298G
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-DD-A1EE-01A	3-gene	p.I310L	421	I302L
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-DX-A6YV-01A	3-gene	p.S152I	421	S144I
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-EA-A439-01A	3-gene	p.S156Y	421	S148Y
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-EE-A20F-06A	3-gene	p.G189W	421	G181W
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-EE-A29R-06A	3-gene	p.P223L	421	P215L
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-EE-A2A2-06A	3-gene	p.F299L	421	F291L
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-EO-A22U-01A	3-gene	p.E115K	421	E107K
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-EO-A22X-01A	3-gene	p.F421L	421	F413L
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-FI-A2D4-01A	3-gene	p.E131K	421	E123K
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-FI-A2F4-01A	3-gene	p.L289P	421	L281P
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-FS-A1ZZ-06A	3-gene	p.F129Y	421	F121Y
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-IN-A7NT-01A	3-gene	p.R239Q	421	R231Q
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-L9-A8F4-01A	3-gene	p.N171S	421	N163S
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-QG-A5Z2-01A	3-gene	p.M383T	421	M375T
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-S3-AA11-01A	5-gene	p.I22K;p.L23I	421	I48K;L49I
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-UY-A9PF-01A	3-gene	p.R103P	421	R95P
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-UZ-A9PN-01A	5-gene	p.H34N	421	H60N
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-WE-A8ZR-06A	3-gene	p.E368D	421	E360D
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-YC-A89H-01A	3-gene	p.E115K	421	E107K
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-YD-A89C-06A	3-gene	p.G325D	421	G317D
ENST00000371602_ENST00000366510_49518553_246899276	TCGA-ZF-A9RC-01A	5-gene	p.E54K	421	E80K
ENST00000396029_ENST00000366510_49518553_246899276	TCGA-17-Z001-01A	5-gene	p.T64R	165	T144R
ENST00000396029_ENST00000366510_49518553_246899276	TCGA-A5-A0G2-01A	5-gene	p.N8D;p.T51N	165	N88D;T131N
ENST00000396029_ENST00000366510_49518553_246899276	TCGA-S3-AA11-01A	5-gene	p.I22K;p.L23I	165	I102K;L103I
ENST00000396029_ENST00000366510_49518553_246899276	TCGA-UZ-A9PN-01A	5-gene	p.H34N	165	H114N
ENST00000396029_ENST00000366510_49518553_246899276	TCGA-ZF-A9RC-01A	5-gene	p.E54K	165	E134K

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for ADNP_SCCPDH

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		PRAD	TCGA-KC-A7F6-01A	ADNP	chr20	49518553	-	SCCPDH	chr1	49518553	+
ChimerDB		PRAD	TCGA-KC-A7F6	ADNP	chr20	49518553	-	SCCPDH	chr1	49518553	+
TCGAfusionPortal		PRAD	TCGA-KC-A7F6-01A	ADNP	chr20	49518554	-	SCCPDH	chr1	246899277	+
WashU		PRAD	TCGA-KC-A7F6-01A	ADNP	chr20	49518554	-	SCCPDH	chr1	246899277	+
cBioPortal	PRAD_TCGA_PAN_CAN_ATLAS_2018	PRAD	TCGA-KC-A7F6-01	ADNP	chr20	50902017		SCCPDH	chr1	246735975

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for ADNP_SCCPDH

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status