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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene Breakpoints

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness

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Fusion Genomic Features

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Fusion Gene ORF Annotations

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Fusion Protein Retained/Non-Retained Functional Features

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Fusion Transcript Sequences

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Fusion Protein Sequences

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Personalized Fusion Protein Sequences

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Fusion Gene Expressed Samples

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Related Drugs

Fusion gene:CBX5_GTSF1 (FusionGDB2 ID:HG23468TG121355)

Fusion Gene Summary for CBX5_GTSF1

check button Fusion gene summary
Fusion gene informationFusion gene name: CBX5_GTSF1
Fusion gene ID: hg23468tg121355
HgeneTgene
Gene symbol

CBX5

GTSF1

Gene ID

23468

121355

Gene namechromobox 5gametocyte specific factor 1
SynonymsHEL25|HP1|HP1A|HP1alphaCue110|FAM112B
Cytomap

12q13.13

12q13.13

Type of geneprotein-codingprotein-coding
Descriptionchromobox protein homolog 5HP1 alpha homologHP1-ALPHAHP1Hs alphaantigen p25chromobox homolog 5 (HP1 alpha homolog, Drosophila)epididymis luminal protein 25heterochromatin protein 1 homolog alphaheterochromatin protein 1-alphagametocyte-specific factor 1asterixfamily with sequence similarity 112, member B
Modification date2024041120240313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000209875, ENST00000439541, 
ENST00000550411, 
Fusion gene scores* DoF score* DoF score (Degree of Frequency) = # partners X # break points X # disease types
24 X 14 X 19=6384		* DoF score (Degree of Frequency) = # partners X # break points X # disease types
3 X 8 X 7=168
# samples 368
** MAII score** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)
log2(36/6384*10)=-4.14839183989267
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)
log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CBX5 [Title/Abstract] AND GTSF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCBX5(54645824)-GTSF1(54865061), # samples:1

check buttonFusion gene breakpoints across CBX5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across GTSF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Fusion Gene Breakpoints for CBX5_GTSF1


check button RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.
HgeneHchrHbpTgeneTchrTbp
CBX5chr1254645824GTSF1chr1254857081
CBX5chr1254645824GTSF1chr1254858951
CBX5chr1254645824GTSF1chr1254865061
CBX5chr1254645825GTSF1chr1254865061


check button DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.
HgeneHchrHbpTgeneTchrTbpSV type


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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for CBX5_GTSF1


check button To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.
* We have 10 tumorigenic mechanism categories of fusion genes as shown below.
Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand FusionsAberrant Chimeric Transcription Factor / Fusion Transcription Factor ActivityEpigenetic Reprogramming / Histone Modifier DysregulationChromatin Remodeling DysregulationCondensate-Driven Transcriptional Rewiring / LLPPromoter / Enhancer HijackingDominant-Negative AntagonismCell Cycle / Checkpoint Bypass / RNA Processing DysregulationSubcellular Mislocalization / Spatial DysregulationNuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.
Fusion Gene NameMechanism CategoryMechanism PubMedTumorigenic ScenariosTumorigenic Scenario PubMedTargeting PointsTargeting PubMedMechanism BackgroundMechanism Background PubMed
CBX5-GTSF1
Epigenetic Reprogramming / Histone Modifier Dysregulation
M3		Promoter swap drives GTSF1 expression, perturbing gametocyte-specific piRNA-mediated transcriptional transposon silencing.Epigenetic modulators; standard chemotherapyGerm-cell tumors and carcinomas

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.
Fusion Gene NameMechanism CategoryMechanism PubMedTumorigenic ScenariosTumorigenic Scenario PubMedTargeting PointsTargeting PubMedMechanism BackgroundMechanism Background PubMed
CBX5-GTSF1
Epigenetic Reprogramming / Histone Modifier Dysregulation
M3		Promoter swap drives GTSF1 expression, perturbing gametocyte-specific piRNA-mediated transcriptional transposon silencing.Epigenetic modulators; standard chemotherapyEvidence level: Limited indirect gene evidence; Confidence: Low; PMID: 24850846; Title: Ectopic expression of cancer-testis antigens in cutaneous T-cell lymphoma patients.Germ-cell tumors and carcinomas

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCBX5

GO:0045892

negative regulation of DNA-templated transcription

9636147


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Fusion Genomic Features for CBX5_GTSF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CBX5chr1254645824-GTSF1chr1254857081-1.27e-081.00e+00
CBX5chr1254645824-GTSF1chr1254858951-7.88e-081.00e+00
CBX5chr1254645824-GTSF1chr1254865061-2.10e-071.00e+00


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).
genomic feature

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Fusion Gene ORF Annotations for CBX5_GTSF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000209875ENST00000305879CBX5chr12

54645824

-GTSF1chr12

54865061

-
5CDS-5UTRENST00000209875ENST00000552395CBX5chr12

54645824

-GTSF1chr12

54857081

-
5CDS-5UTRENST00000209875ENST00000552395CBX5chr12

54645824

-GTSF1chr12

54865061

-
5CDS-5UTRENST00000209875ENST00000552397CBX5chr12

54645824

-GTSF1chr12

54865061

-
5CDS-5UTRENST00000439541ENST00000305879CBX5chr12

54645824

-GTSF1chr12

54865061

-
5CDS-5UTRENST00000439541ENST00000552395CBX5chr12

54645824

-GTSF1chr12

54857081

-
5CDS-5UTRENST00000439541ENST00000552395CBX5chr12

54645824

-GTSF1chr12

54865061

-
5CDS-5UTRENST00000439541ENST00000552397CBX5chr12

54645824

-GTSF1chr12

54865061

-
5CDS-5UTRENST00000550411ENST00000305879CBX5chr12

54645824

-GTSF1chr12

54865061

-
5CDS-5UTRENST00000550411ENST00000552395CBX5chr12

54645824

-GTSF1chr12

54857081

-
5CDS-5UTRENST00000550411ENST00000552395CBX5chr12

54645824

-GTSF1chr12

54865061

-
5CDS-5UTRENST00000550411ENST00000552397CBX5chr12

54645824

-GTSF1chr12

54865061

-
Frame-shiftENST00000209875ENST00000305879CBX5chr12

54645824

-GTSF1chr12

54857081

-
Frame-shiftENST00000209875ENST00000305879CBX5chr12

54645824

-GTSF1chr12

54858951

-
Frame-shiftENST00000209875ENST00000552397CBX5chr12

54645824

-GTSF1chr12

54857081

-
Frame-shiftENST00000209875ENST00000552397CBX5chr12

54645824

-GTSF1chr12

54858951

-
Frame-shiftENST00000439541ENST00000305879CBX5chr12

54645824

-GTSF1chr12

54857081

-
Frame-shiftENST00000439541ENST00000305879CBX5chr12

54645824

-GTSF1chr12

54858951

-
Frame-shiftENST00000439541ENST00000552397CBX5chr12

54645824

-GTSF1chr12

54857081

-
Frame-shiftENST00000439541ENST00000552397CBX5chr12

54645824

-GTSF1chr12

54858951

-
Frame-shiftENST00000550411ENST00000305879CBX5chr12

54645824

-GTSF1chr12

54857081

-
Frame-shiftENST00000550411ENST00000552397CBX5chr12

54645824

-GTSF1chr12

54857081

-
In-frameENST00000550411ENST00000305879CBX5chr12

54645824

-GTSF1chr12

54858951

-
In-frameENST00000550411ENST00000552397CBX5chr12

54645824

-GTSF1chr12

54858951

-

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)
ENST00000550411ENST00000305879CBX5chr1254645824GTSF1chr1254858951642238
ENST00000550411ENST00000552397CBX5chr1254645824GTSF1chr1254858951642162

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score
ENST00000550411ENST00000305879CBX5chr1254645824GTSF1chr12548589519.38e-029.06e-01
ENST00000550411ENST00000552397CBX5chr1254645824GTSF1chr12548589519.35e-029.06e-01

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score

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Fusion Protein Retained/Non-Retained Functional Features for CBX5_GTSF1

check buttonProtein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.
fgviewer annotation
- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).
CBX5_GTSF1_chr12-54645824_chr12-54858951.png
CBX5_GTSF1_chr12-54645824_chr12-54858951.png

- In-frame and retained protein feature among the 13 regional features (texts).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCBX5chr12:54645824chr12:54858951ENST00000550411P459733573_89108.0192.0Compositional biasBasic and acidic residues
HgeneCBX5chr12:54645824chr12:54858951ENST00000550411P459733520_78108.0192.0DomainChromo 1
TgeneGTSF1chr12:54645824chr12:54858951ENST00000305879Q8WW331914_415.333333333333333213.0Zinc fingerCHHC U11-48K-type 1
TgeneGTSF1chr12:54645824chr12:54858951ENST00000305879Q8WW331948_755.333333333333333213.0Zinc fingerCHHC U11-48K-type 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCBX5chr12:54645824chr12:54858951ENST00000550411P4597335121_179108.0192.0DomainChromo 2%3B shadow subtype
HgeneCBX5chr12:54645824chr12:54858951ENST00000550411P459733570_117108.0192.0RegionDisordered


check button - Retained PPIs in in-frame fusion.
PartnerHgeneHbpTgeneTbpENSTUniProtStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerHgeneHbpTgeneTbpENSTUniProtStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Fusion Transcript Sequence for CBX5_GTSF1

check button In-frame Fusion Transcript Sequences.
>CBX5_GTSF1_ENST00000550411_ENST00000305879_54645824_54858951 length=1347nt
Breakpoint=642nt
GTTAGCCCAGAGGGAAAGAAAGAACTGGGGCGATCCGGTAGGTAAAGGAGGGAACCCCCATTCATTTTCTACCTTTGGGGCTCCTCTTCTGCATGAAGGTATAAAGGGAGATTTTCCTTGTCTCTCCCTCAAAATGAAGAACACATGTAA
ATCCTTGTTTTTCCTGGTGAGGCAGGGGAGGCCATAGCCACAATGCTTAACTGCATGCATCTAACATGGGGCTGGTTTTAACCCCAGCGCTCTGACCTAAACTGCTCAGCTCCCGGAAATTCCAAGGGACCTGGTGGCCTTAGTCTTTCA
GGTGGAACGGTGTGCGACATGGGAAAGAAAACCAAGCGGACAGCTGACAGTTCTTCTTCAGAGGATGAGGAGGAGTATGTTGTGGAGAAGGTGCTAGACAGGCGCGTGGTTAAGGGACAAGTGGAATATCTACTGAAGTGGAAAGGCTTT
TCTGAGGAGCACAATACTTGGGAACCTGAGAAAAACTTGGATTGCCCTGAGCTAATTTCTGAATTTATGAAAAAGTATAAGAAGATGAAGGAGGGTGAAAATAATAAACCCAGGGAGAAGTCAGAAAGTAACAAGAGGAAATCCAATTTC
TCAAACAGTGCCGATGACATCAAATCTAAAAAAAAGAGAGAGCCGACTCCCTGGACCCTGAGAAGCTATTGCAATGCCCCTATGACAAAAACCATCAAATCAGGGCTTGCAGGTTTCCTTATCATCTTATCAAGTGCAGAAAGAATCATC
CTGATGTTGCAAGCAAATTGGCTACTTGTCCCTTCAATGCTCGCCACCAGGTTCCTCGAGCTGAAATTAGTCATCATATCTCAAGCTGTGATGACAGAAGTTGTATTGAGCAAGATGTTGTCAACCAAACCAGGAGCCTTAGACAAGAGA
CTCTGGCTGAGAGCACTTGGCAGTGCCCTCCTTGCGATGAAGACTGGGATAAAGATTTGTGGGAGCAGACCAGCACCCCATTTGTCTGGGGCACAACTCACTACTCTGACAACAACAGCCCTGCGAGCAACATAGTTACAGAACATAAGA
ATAACCTGGCTTCAGGCATGCGAGTTCCCAAATCTCTGCCGTATGTTCTGCCATGGAAAAACAATGGAAATGCACAGTAACTGAATACCTATCTCATCAAATGCCAGACCCTAGAAGACTGTTGCTTCTTCTTCTACCAGTGGGTTCTCA
TTTTCCTCCTAATCTAATTATAGAATGGTAAACTCCCTGTGACTTTCCAAACTGACAAGCACACTTTTTTCCTCCCCCCTTGAATCCTCATTTAATGCAAGAACCCTCATACTCAGAAGCTTCCAAATAAACCTTTGATACAGATTG

>CBX5_GTSF1_ENST00000550411_ENST00000552397_54645824_54858951 length=1350nt
Breakpoint=642nt
GTTAGCCCAGAGGGAAAGAAAGAACTGGGGCGATCCGGTAGGTAAAGGAGGGAACCCCCATTCATTTTCTACCTTTGGGGCTCCTCTTCTGCATGAAGGTATAAAGGGAGATTTTCCTTGTCTCTCCCTCAAAATGAAGAACACATGTAA
ATCCTTGTTTTTCCTGGTGAGGCAGGGGAGGCCATAGCCACAATGCTTAACTGCATGCATCTAACATGGGGCTGGTTTTAACCCCAGCGCTCTGACCTAAACTGCTCAGCTCCCGGAAATTCCAAGGGACCTGGTGGCCTTAGTCTTTCA
GGTGGAACGGTGTGCGACATGGGAAAGAAAACCAAGCGGACAGCTGACAGTTCTTCTTCAGAGGATGAGGAGGAGTATGTTGTGGAGAAGGTGCTAGACAGGCGCGTGGTTAAGGGACAAGTGGAATATCTACTGAAGTGGAAAGGCTTT
TCTGAGGAGCACAATACTTGGGAACCTGAGAAAAACTTGGATTGCCCTGAGCTAATTTCTGAATTTATGAAAAAGTATAAGAAGATGAAGGAGGGTGAAAATAATAAACCCAGGGAGAAGTCAGAAAGTAACAAGAGGAAATCCAATTTC
TCAAACAGTGCCGATGACATCAAATCTAAAAAAAAGAGAGAGCCGACTCCCTGGACCCTGAGAAGCTATTGCAATGCCCCTATGACAAAAACCATCAAATCAGGGCTTGCAGGTTTCCTTATCATCTTATCAAGTGCAGAAAGAATCATC
CTGATGTTGCAAGCAAATTGGCTACTTGTCCCTTCAATGCTCGCCACCAGGTTCCTCGAGCTGAAATTAGTCATCATATCTCAAGCTGTGATGACAGAAGTTGTATTGAGCAAGATGTTGTCAACCAAACCAGGAGCCTTAGACAAGAGA
CTCTGGCTGAGAGCACTTGGCAGTGCCCTCCTTGCGATGAAGACTGGGATAAAGATTTGTGGGAGCAGACCAGCACCCCATTTGTCTGGGGCACAACTCACTACTCTGACAACAACAGCCCTGCGAGCAACATAGTTACAGAACATAAGA
ATAACCTGGCTTCAGGCATGCGAGTTCCCAAATCTCTGCCGTATGTTCTGCCATGGAAAAACAATGGAAATGCACAGTAACTGAATACCTATCTCATCAAATGCCAGACCCTAGAAGACTGTTGCTTCTTCTTCTACCAGTGGGTTCTCA
TTTTCCTCCTAATCTAATTATAGAATGGTAAACTCCCTGTGACTTTCCAAACTGACAAGCACACTTTTTTCCTCCCCCCTTGAATCCTCATTTAATGCAAGAACCCTCATACTCAGAAGCTTCCAAATAAACCTTTGATACAGATTGCTT



check button N-Truncated Transcript (5UTR-3CDS) Sequences

check button C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for CBX5_GTSF1

check button In-frame Fusion Protein Sequences.
>CBX5_GTSF1_ENST00000550411_ENST00000305879_54645824_54858951 length=238nt
MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREPTPWTLRSYCNAPMTKTIKSGLAGFLIILSSAERIILMLQAN
WLLVPSMLATRFLELKLVIISQAVMTEVVLSKMLSTKPGALDKRLWLRALGSALLAMKTGIKICGSRPAPHLSGAQLTTLTTTALRAT

>CBX5_GTSF1_ENST00000550411_ENST00000552397_54645824_54858951 length=162nt
MRLGVMLTSPSQGWPRGLLFASWFSRPVSWKHGEHHFWTLRPCRASVISTTQVQQRFLVVALSVLLGDQPLHFTRYSTLPLRIRFFSMLSTAKTCSPTAGSSMAEPERAGALAAGAAADAASSRRRPAAAPAEAPPPPPPLAPHSPAGPP
LPAPAPAPGSRS


check button N-Truncated Protein (5UTR-3CDS) Sequences

check button C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for CBX5_GTSF1


check button TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences
NumGene GroupDomain LociFusion Protein IDFusion Gene NamePartnerMutated Residue in WT ProteinSeq. LengthMutated Residue in Fusion Protein

check button CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

NumGene GroupDomain LociFusion Protein IDFusion Gene NamePartnerMutated Residue in WT ProteinSeq. LengthMutated Residue in Fusion Protein

check button TCGA All Mutated Fusion Protein Sequences


Fusion Protein IDSample IDMutated PartnerAAchange in WTSeq. LengthAAchange in Fusion

check button CCLE All Mutated Fusion Protein Sequences


Fusion Protein IDSample IDMutated PartnerAAchange in WTSeq. LengthAAchange in Fusion

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Fusion Gene Exprssed Samples for CBX5_GTSF1


check buttonRNA-seq based fusion gene expressed samples.
SourceStudyDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDBOVTCGA-25-1329-01ACBX5

chr12

54645824-GTSF1

chr12

54857081

-
ChimerDBOVTCGA-25-1329-01ACBX5

chr12

54645824-GTSF1

chr12

54858951

-
ChimerDBOVTCGA-25-1329-01ACBX5

chr12

54645824-GTSF1

chr12

54865061

-
WashUOVTCGA-25-1329-01ACBX5

chr12

54645825-GTSF1

chr12

54865061

-

check buttonDNA-seq based fusion gene expressed samples.
SourceStudyDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrandSV type


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Related Drugs for CBX5_GTSF1


check button PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.
PMIDFusion Gene NameDrugStudy Title

check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status