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Fusion gene:ACOT9_APOO (FusionGDB2 ID:HG23597TG79135) |
Fusion Gene Summary for ACOT9_APOO |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACOT9_APOO | Fusion gene ID: hg23597tg79135 | Hgene | Tgene | Gene symbol | ACOT9 | APOO | Gene ID | 23597 | 79135 |
| Gene name | acyl-CoA thioesterase 9 | apolipoprotein O | |
| Synonyms | ACATE2|CGI-16|MT-ACT48|MTACT48 | FAM121B|MIC26|MICOS26|Mic23|My025 | |
| Cytomap | Xp22.11 | Xp22.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | acyl-coenzyme A thioesterase 9, mitochondrialacyl-CoA thioester hydrolase 9acyl-Coenzyme A thioesterase 2, mitochondrialmitochondrial Acyl-CoA Thioesterase | MICOS complex subunit MIC26MICOS complex subunit MIC23brain my025family with sequence similarity 121Bmitochondrial contact site and cristae organizing system subunit 26 | |
| Modification date | 20240407 | 20240407 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000336430, ENST00000379295, ENST00000379303, ENST00000492081, | ENST00000379295, ENST00000336430, ENST00000379303, ENST00000492081, | |
| Fusion gene scores | * DoF score | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 1 X 9 X 7=63 | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 6 X 14 X 13=1092 |
| # samples | 13 | 23 | |
| ** MAII score | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(13/63*10)=1.04508788952854 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(23/1092*10)=-2.24726708997548 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ACOT9 [Title/Abstract] AND APOO [Title/Abstract] AND fusion [Title/Abstract] The landscape and therapeutic relevance of cancer-associated transcript fusions (pmid: Â 25500544) | ||
| Most frequent breakpoint | ACOT9(23739997)-APOO(23899069), # samples:9 | ||
| Fusion gene breakpoints across ACOT9 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across APOO (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Breakpoints for ACOT9_APOO |
| RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ACOT9 | chrX | 23761242 | APOO | chrX | 23876850 |
| ACOT9 | chrX | 23748644 | APOO | chrX | 23886805 |
| ACOT9 | chrX | 23731251 | APOO | chrX | 23899069 |
| ACOT9 | chrX | 23739997 | APOO | chrX | 23899068 |
| ACOT9 | chrX | 23739997 | APOO | chrX | 23899069 |
| ACOT9 | chrX | 23748643 | APOO | chrX | 23851626 |
| ACOT9 | chrX | 23748643 | APOO | chrX | 23851627 |
| ACOT9 | chrX | 23748643 | APOO | chrX | 23851728 |
| ACOT9 | chrX | 23748643 | APOO | chrX | 23851729 |
| ACOT9 | chrX | 23761241 | APOO | chrX | 23851626 |
| ACOT9 | chrX | 23761241 | APOO | chrX | 23851627 |
| ACOT9 | chrX | 23761241 | APOO | chrX | 23851728 |
| ACOT9 | chrX | 23761241 | APOO | chrX | 23851729 |
| ACOT9 | chrX | 23721940 | APOO | chrX | 23876850 |
| ACOT9 | chrX | 23721965 | APOO | chrX | 23876850 |
| ACOT9 | chrX | 23739998 | APOO | chrX | 23892574 |
| DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | SV type |
| ACOT9 | chrX | 23761122 | APOO | chrX | 23862997 | DEL |
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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for ACOT9_APOO |
| To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence. |
| Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions | Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity | Epigenetic Reprogramming / Histone Modifier Dysregulation | Chromatin Remodeling Dysregulation | Condensate-Driven Transcriptional Rewiring / LLP | Promoter / Enhancer Hijacking | Dominant-Negative Antagonism | Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation | Subcellular Mislocalization / Spatial Dysregulation | Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade |  |  |  |  |  |  |  |  |  |  |
* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
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Fusion Genomic Features for ACOT9_APOO |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| ACOT9 | chrX | 23731251 | - | APOO | chrX | 23899069 | - | 8.10e-06 | 1.00e+00 |
| ACOT9 | chrX | 23739997 | - | APOO | chrX | 23899069 | - | 1.36e-12 | 1.00e+00 |
| ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851627 | - | 8.35e-09 | 1.00e+00 |
| ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851729 | - | 1.24e-07 | 1.00e+00 |
| ACOT9 | chrX | 23748643 | - | APOO | chrX | 23886805 | - | 2.96e-09 | 1.00e+00 |
| ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851627 | - | 2.91e-09 | 1.00e+00 |
| ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851729 | - | 4.16e-08 | 1.00e+00 |
| ACOT9 | chrX | 23761241 | - | APOO | chrX | 23876850 | - | 2.29e-05 | 1.00e+00 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| ACOT9 | chrX | 23761241 | - | APOO | chrX | 23876850 | - | 2.29e-05 | 1.00e+00 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF). |
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Fusion Gene ORF Annotations for ACOT9_APOO |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000336430 | ENST00000379220 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851627 | - |
| 5CDS-3UTR | ENST00000336430 | ENST00000379220 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851729 | - |
| 5CDS-3UTR | ENST00000336430 | ENST00000379220 | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851627 | - |
| 5CDS-3UTR | ENST00000336430 | ENST00000379220 | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851729 | - |
| 5CDS-3UTR | ENST00000336430 | ENST00000379226 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851627 | - |
| 5CDS-3UTR | ENST00000336430 | ENST00000379226 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851729 | - |
| 5CDS-3UTR | ENST00000336430 | ENST00000379226 | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851627 | - |
| 5CDS-3UTR | ENST00000336430 | ENST00000379226 | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851729 | - |
| 5CDS-3UTR | ENST00000379295 | ENST00000379220 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851627 | - |
| 5CDS-3UTR | ENST00000379295 | ENST00000379220 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851729 | - |
| 5CDS-3UTR | ENST00000379295 | ENST00000379226 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851627 | - |
| 5CDS-3UTR | ENST00000379295 | ENST00000379226 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851729 | - |
| 5CDS-3UTR | ENST00000379303 | ENST00000379220 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851627 | - |
| 5CDS-3UTR | ENST00000379303 | ENST00000379220 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851729 | - |
| 5CDS-3UTR | ENST00000379303 | ENST00000379220 | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851627 | - |
| 5CDS-3UTR | ENST00000379303 | ENST00000379220 | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851729 | - |
| 5CDS-3UTR | ENST00000379303 | ENST00000379226 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851627 | - |
| 5CDS-3UTR | ENST00000379303 | ENST00000379226 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851729 | - |
| 5CDS-3UTR | ENST00000379303 | ENST00000379226 | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851627 | - |
| 5CDS-3UTR | ENST00000379303 | ENST00000379226 | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851729 | - |
| 5CDS-3UTR | ENST00000492081 | ENST00000379220 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851627 | - |
| 5CDS-3UTR | ENST00000492081 | ENST00000379220 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851729 | - |
| 5CDS-3UTR | ENST00000492081 | ENST00000379226 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851627 | - |
| 5CDS-3UTR | ENST00000492081 | ENST00000379226 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851729 | - |
| 5CDS-5UTR | ENST00000336430 | ENST00000476598 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851627 | - |
| 5CDS-5UTR | ENST00000336430 | ENST00000476598 | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851627 | - |
| 5CDS-5UTR | ENST00000379295 | ENST00000476598 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851627 | - |
| 5CDS-5UTR | ENST00000379303 | ENST00000476598 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851627 | - |
| 5CDS-5UTR | ENST00000379303 | ENST00000476598 | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851627 | - |
| 5CDS-5UTR | ENST00000492081 | ENST00000476598 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851627 | - |
| 5UTR-3CDS | ENST00000492081 | ENST00000379226 | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23876850 | - |
| 5UTR-3UTR | ENST00000492081 | ENST00000379220 | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851627 | - |
| 5UTR-3UTR | ENST00000492081 | ENST00000379220 | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851729 | - |
| 5UTR-3UTR | ENST00000492081 | ENST00000379226 | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851627 | - |
| 5UTR-3UTR | ENST00000492081 | ENST00000379226 | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851729 | - |
| 5UTR-5UTR | ENST00000492081 | ENST00000476598 | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851627 | - |
| Frame-shift | ENST00000336430 | ENST00000379226 | ACOT9 | chrX | 23731251 | - | APOO | chrX | 23899069 | - |
| Frame-shift | ENST00000336430 | ENST00000379226 | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23876850 | - |
| Frame-shift | ENST00000379295 | ENST00000379226 | ACOT9 | chrX | 23731251 | - | APOO | chrX | 23899069 | - |
| Frame-shift | ENST00000379295 | ENST00000379226 | ACOT9 | chrX | 23739997 | - | APOO | chrX | 23899069 | - |
| Frame-shift | ENST00000379295 | ENST00000379226 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23886805 | - |
| Frame-shift | ENST00000379303 | ENST00000379226 | ACOT9 | chrX | 23731251 | - | APOO | chrX | 23899069 | - |
| Frame-shift | ENST00000379303 | ENST00000379226 | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23876850 | - |
| Frame-shift | ENST00000492081 | ENST00000379226 | ACOT9 | chrX | 23739997 | - | APOO | chrX | 23899069 | - |
| Frame-shift | ENST00000492081 | ENST00000379226 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23886805 | - |
| In-frame | ENST00000336430 | ENST00000379226 | ACOT9 | chrX | 23739997 | - | APOO | chrX | 23899069 | - |
| In-frame | ENST00000336430 | ENST00000379226 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23886805 | - |
| In-frame | ENST00000379303 | ENST00000379226 | ACOT9 | chrX | 23739997 | - | APOO | chrX | 23899069 | - |
| In-frame | ENST00000379303 | ENST00000379226 | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23886805 | - |
| ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ENST00000336430 | ENST00000379226 | ACOT9 | chrX | 23739997 | APOO | chrX | 23892574 | 693 | 315 |
| ENST00000336430 | ENST00000379226 | ACOT9 | chrX | 23739997 | APOO | chrX | 23899069 | 693 | 391 |
| ENST00000336430 | ENST00000379226 | ACOT9 | chrX | 23748643 | APOO | chrX | 23886805 | 505 | 234 |
| ENST00000379303 | ENST00000379226 | ACOT9 | chrX | 23739997 | APOO | chrX | 23892574 | 717 | 979 |
| ENST00000379303 | ENST00000379226 | ACOT9 | chrX | 23739997 | APOO | chrX | 23899069 | 717 | 561 |
| ENST00000379303 | ENST00000379226 | ACOT9 | chrX | 23748643 | APOO | chrX | 23886805 | 529 | 182 |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ENST00000492081 | ENST00000379226 | ACOT9 | chrX | 23761241 | APOO | chrX | 23876850 | 0 | 113 |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| ENST00000336430 | ENST00000379226 | ACOT9 | chrX | 23739997 | APOO | chrX | 23892574 | 2.36e-03 | 9.98e-01 |
| ENST00000336430 | ENST00000379226 | ACOT9 | chrX | 23739997 | APOO | chrX | 23899069 | 1.86e-03 | 9.98e-01 |
| ENST00000336430 | ENST00000379226 | ACOT9 | chrX | 23748643 | APOO | chrX | 23886805 | 5.27e-03 | 9.95e-01 |
| ENST00000379303 | ENST00000379226 | ACOT9 | chrX | 23739997 | APOO | chrX | 23892574 | 2.84e-03 | 9.97e-01 |
| ENST00000379303 | ENST00000379226 | ACOT9 | chrX | 23739997 | APOO | chrX | 23899069 | 2.51e-03 | 9.97e-01 |
| ENST00000379303 | ENST00000379226 | ACOT9 | chrX | 23748643 | APOO | chrX | 23886805 | 8.26e-03 | 9.92e-01 |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| ENST00000492081 | ENST00000379226 | ACOT9 | chrX | 23761241 | APOO | chrX | 23876850 | 0.00e+00 | 6.08e-01 |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| ENST00000336430 | ENST00000379220 | ACOT9 | chrX | 23748643 | APOO | chrX | 23851729 | 0.00e+00 | 6.26e-01 |
| ENST00000336430 | ENST00000379226 | ACOT9 | chrX | 23748643 | APOO | chrX | 23851729 | 0.00e+00 | 6.26e-01 |
| ENST00000379295 | ENST00000379220 | ACOT9 | chrX | 23748643 | APOO | chrX | 23851729 | 0.00e+00 | 9.58e-01 |
| ENST00000379295 | ENST00000379226 | ACOT9 | chrX | 23748643 | APOO | chrX | 23851729 | 0.00e+00 | 9.58e-01 |
| ENST00000379303 | ENST00000379220 | ACOT9 | chrX | 23748643 | APOO | chrX | 23851729 | 0.00e+00 | 3.72e-01 |
| ENST00000379303 | ENST00000379226 | ACOT9 | chrX | 23748643 | APOO | chrX | 23851729 | 0.00e+00 | 3.72e-01 |
| ENST00000492081 | ENST00000379220 | ACOT9 | chrX | 23748643 | APOO | chrX | 23851729 | 0.00e+00 | 4.62e-01 |
| ENST00000492081 | ENST00000379226 | ACOT9 | chrX | 23748643 | APOO | chrX | 23851729 | 0.00e+00 | 4.62e-01 |
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Fusion Protein Retained/Non-Retained Functional Features for ACOT9_APOO |
| Protein Level Annotation from FGviewer * Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS. |
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| - In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length). |
ACOT9_APOO_chrX-23739997_chrX-23892574.png |
ACOT9_APOO_chrX-23739997_chrX-23899069.png |
ACOT9_APOO_chrX-23748643_chrX-23886805.png |
| - In-frame and retained protein feature among the 13 regional features (texts). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | APOO | chrX:23739997 | chrX:23892574 | ENST00000379226 | Q9BUR5 | 2 | 9 | 108_128 | 79.0 | 191.0 | Transmembrane | Helical |
| Tgene | APOO | chrX:23739997 | chrX:23899069 | ENST00000379226 | Q9BUR5 | 0 | 9 | 108_128 | 3.0 | 191.0 | Transmembrane | Helical |
| Tgene | APOO | chrX:23748643 | chrX:23886805 | ENST00000379226 | Q9BUR5 | 3 | 9 | 108_128 | 97.33333333333333 | 191.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ACOT9 | chrX:23739997 | chrX:23899069 | ENST00000336430 | Q9Y305 | 7 | 15 | 289_401 | 187.0 | 440.0 | Domain | HotDog ACOT-type 2 |
| Hgene | ACOT9 | chrX:23739997 | chrX:23899069 | ENST00000336430 | Q9Y305 | 7 | 15 | 84_209 | 187.0 | 440.0 | Domain | HotDog ACOT-type 1 |
| Hgene | ACOT9 | chrX:23748643 | chrX:23886805 | ENST00000336430 | Q9Y305 | 5 | 15 | 289_401 | 124.33333333333333 | 440.0 | Domain | HotDog ACOT-type 2 |
| Hgene | ACOT9 | chrX:23748643 | chrX:23886805 | ENST00000336430 | Q9Y305 | 5 | 15 | 84_209 | 124.33333333333333 | 440.0 | Domain | HotDog ACOT-type 1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Fusion Transcript Sequence for ACOT9_APOO |
| In-frame Fusion Transcript Sequences. |
>ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23892574 length=1342nt Breakpoint=693nt GCTGTCCGGCTCCCGGGCTGTCCTCAGCAAGGGCGCGGTCTGGTACTCGTGCGTCTTTTATCGCCTCAGTTTCCCTCCGCCGACTAGCGCGCGGGGCCCGGTTCTCCATCGCGCGCACGGCAGCCTAGCGCAATGAGGCGGGCAGCACTG CGGCTTTGTGCCTTGGGCAAAGGGCAGCTTACTCCTGGAAGAGGACTGACTCAAGGACCCCAGAACCCCAAGAAACAGGGAATCTTCCACATTCATGAAGTTCGAGATAAGTTGCGGGAGATAGTAGGAGCATCCACAAACTGGAGAGAC CATGTGAAGGCAATGGAAGAAAGGAAATTACTTCATAGTTTCTTGGCTAAATCACAGGATGGACTGCCTCCTAGGAGAATGAAGGACAGTTATATTGAAGTTCTCTTGCCTTTGGGCAGTGAGCCTGAATTACGAGAGAAATATTTGACT GTTCAAAACACCGTAAGATTTGGCAGGATTCTTGAGGATCTTGACAGCTTGGGAGTTCTTATTTGTTACATGCACAACAAAATCCACTCCGCCAAGATGTCTCCTTTATCGATAGTTACAGCCCTGGTGGATAAGATTGATATGTGTAAG AAGAGCTTGAGCCCAGAACAGGACATTAAGTTCAGTGGCCATGTTAGCTGGGTCGGGAAGACATCCATGGAAGTGAAGATGCAAATGTTCCAGGAAACGTACTCCCAAACTAAGCCCAAGATGCAAAGTTTGGTTCAATGGGGGTTAGAC AGCTATGACTATCTCCAAAATGCACCTCCTGGATTTTTTCCGAGACTTGGTGTTATTGGTTTTGCTGGCCTTATTGGACTCCTTTTGGCTAGAGGTTCAAAAATAAAGAAGCTAGTGTATCCGCCTGGTTTCATGGGATTAGCTGCCTCC CTCTATTATCCACAACAAGCCATCGTGTTTGCCCAGGTCAGTGGGGAGAGATTATATGACTGGGGTTTACGAGGATATATAGTCATAGAAGATTTGTGGAAGGAGAACTTTCAAAAGCCAGGAAATGTGAAGAATTCACCTGGAACTAAG TAGAAAACTCCATGCTCTGCCATCTTAATCAGTTATAGGTAAACATTGGAAACTCCATAGAATAAATCAGTATTTCTACAGAAAAATGGCATAGAAGTCAGTATTGAATGTATTAAATTGGCTTTCTTCTTCAGGAAAAACTAGACCAGA CCTCTGTTATCTTCTGTGAAATCATCCTACAAGCAAACTAACCTGGAATCCCTTCACCTAGAGATAATGTACAAGCCTTAGAACTCCTCATTCTCATGTTGCTATTTATGTACCTAATTAAAACCCAAGTTAAAAAAAAAAA >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069 length=1570nt Breakpoint=693nt GCTGTCCGGCTCCCGGGCTGTCCTCAGCAAGGGCGCGGTCTGGTACTCGTGCGTCTTTTATCGCCTCAGTTTCCCTCCGCCGACTAGCGCGCGGGGCCCGGTTCTCCATCGCGCGCACGGCAGCCTAGCGCAATGAGGCGGGCAGCACTG CGGCTTTGTGCCTTGGGCAAAGGGCAGCTTACTCCTGGAAGAGGACTGACTCAAGGACCCCAGAACCCCAAGAAACAGGGAATCTTCCACATTCATGAAGTTCGAGATAAGTTGCGGGAGATAGTAGGAGCATCCACAAACTGGAGAGAC CATGTGAAGGCAATGGAAGAAAGGAAATTACTTCATAGTTTCTTGGCTAAATCACAGGATGGACTGCCTCCTAGGAGAATGAAGGACAGTTATATTGAAGTTCTCTTGCCTTTGGGCAGTGAGCCTGAATTACGAGAGAAATATTTGACT GTTCAAAACACCGTAAGATTTGGCAGGATTCTTGAGGATCTTGACAGCTTGGGAGTTCTTATTTGTTACATGCACAACAAAATCCACTCCGCCAAGATGTCTCCTTTATCGATAGTTACAGCCCTGGTGGATAAGATTGATATGTGTAAG AAGAGCTTGAGCCCAGAACAGGACATTAAGTTCAGTGGCCATGTTAGCTGGGTCGGGAAGACATCCATGGAAGTGAAGATGCAAATGTTCCAGGTAATTCAGAGGTCCGTGGGGCCAGCCAGCCTGAGCTTGCTCACCTTCAAAGTCTAT GCAGCACCAAAAAAGGACTCACCTCCCAAAAATTCCGTGAAGGTTGATGAGCTTTCACTCTACTCAGTTCCTGAGGGTCAATCGAAGTATGTGGAGGAGGCAAGGAGCCAGCTTGAAGAAAGCATCTCACAGCTCCGACACTATTGCGAG CCATACACAACCTGGTGTCAGGAAACGTACTCCCAAACTAAGCCCAAGATGCAAAGTTTGGTTCAATGGGGGTTAGACAGCTATGACTATCTCCAAAATGCACCTCCTGGATTTTTTCCGAGACTTGGTGTTATTGGTTTTGCTGGCCTT ATTGGACTCCTTTTGGCTAGAGGTTCAAAAATAAAGAAGCTAGTGTATCCGCCTGGTTTCATGGGATTAGCTGCCTCCCTCTATTATCCACAACAAGCCATCGTGTTTGCCCAGGTCAGTGGGGAGAGATTATATGACTGGGGTTTACGA GGATATATAGTCATAGAAGATTTGTGGAAGGAGAACTTTCAAAAGCCAGGAAATGTGAAGAATTCACCTGGAACTAAGTAGAAAACTCCATGCTCTGCCATCTTAATCAGTTATAGGTAAACATTGGAAACTCCATAGAATAAATCAGTA TTTCTACAGAAAAATGGCATAGAAGTCAGTATTGAATGTATTAAATTGGCTTTCTTCTTCAGGAAAAACTAGACCAGACCTCTGTTATCTTCTGTGAAATCATCCTACAAGCAAACTAACCTGGAATCCCTTCACCTAGAGATAATGTAC AAGCCTTAGAACTCCTCATTCTCATGTTGCTATTTATGTACCTAATTAAAACCCAAGTTAAAAAAAAAAA >ACOT9_APOO_ENST00000336430_ENST00000379226_23748643_23886805 length=1099nt Breakpoint=505nt GCTGTCCGGCTCCCGGGCTGTCCTCAGCAAGGGCGCGGTCTGGTACTCGTGCGTCTTTTATCGCCTCAGTTTCCCTCCGCCGACTAGCGCGCGGGGCCCGGTTCTCCATCGCGCGCACGGCAGCCTAGCGCAATGAGGCGGGCAGCACTG CGGCTTTGTGCCTTGGGCAAAGGGCAGCTTACTCCTGGAAGAGGACTGACTCAAGGACCCCAGAACCCCAAGAAACAGGGAATCTTCCACATTCATGAAGTTCGAGATAAGTTGCGGGAGATAGTAGGAGCATCCACAAACTGGAGAGAC CATGTGAAGGCAATGGAAGAAAGGAAATTACTTCATAGTTTCTTGGCTAAATCACAGGATGGACTGCCTCCTAGGAGAATGAAGGACAGTTATATTGAAGTTCTCTTGCCTTTGGGCAGTGAGCCTGAATTACGAGAGAAATATTTGACT GTTCAAAACACCGTAAGATTTGGCAGGATTCTTGAGGATCTTGACAGCTTGGGAGACAGCTATGACTATCTCCAAAATGCACCTCCTGGATTTTTTCCGAGACTTGGTGTTATTGGTTTTGCTGGCCTTATTGGACTCCTTTTGGCTAGA GGTTCAAAAATAAAGAAGCTAGTGTATCCGCCTGGTTTCATGGGATTAGCTGCCTCCCTCTATTATCCACAACAAGCCATCGTGTTTGCCCAGGTCAGTGGGGAGAGATTATATGACTGGGGTTTACGAGGATATATAGTCATAGAAGAT TTGTGGAAGGAGAACTTTCAAAAGCCAGGAAATGTGAAGAATTCACCTGGAACTAAGTAGAAAACTCCATGCTCTGCCATCTTAATCAGTTATAGGTAAACATTGGAAACTCCATAGAATAAATCAGTATTTCTACAGAAAAATGGCATA GAAGTCAGTATTGAATGTATTAAATTGGCTTTCTTCTTCAGGAAAAACTAGACCAGACCTCTGTTATCTTCTGTGAAATCATCCTACAAGCAAACTAACCTGGAATCCCTTCACCTAGAGATAATGTACAAGCCTTAGAACTCCTCATTC TCATGTTGCTATTTATGTACCTAATTAAAACCCAAGTTAAAAAAAAAAA >ACOT9_APOO_ENST00000379303_ENST00000379226_23739997_23892574 length=1366nt Breakpoint=717nt GTCCGGCTCCCGGGCTGTCCTCAGCAAGGGCGCGGTCTGGTACTCGTGCGTCTTTTATCGCCTCAGTTTCCCTCCGCCGACTAGCGCGCGGGGCCCGGTTCTCCATCGCGCGCACGGCAGCCTAGCGCAATGAGGCGGGCAGCACTGCGG CTTTGTGCCTTGGGCAAAGGGCAGCTTACTCCTGGAAGAGGACTGACTCAAGGACCCCAGAACCCCAAGAAACAGGGAATCTTCCACATTCATGAAGCATGTTCATCTATACATGTGAATCATGTTCGAGATAAGTTGCGGGAGATAGTA GGAGCATCCACAAACTGGAGAGACCATGTGAAGGCAATGGAAGAAAGGAAATTACTTCATAGTTTCTTGGCTAAATCACAGGATGGACTGCCTCCTAGGAGAATGAAGGACAGTTATATTGAAGTTCTCTTGCCTTTGGGCAGTGAGCCT GAATTACGAGAGAAATATTTGACTGTTCAAAACACCGTAAGATTTGGCAGGATTCTTGAGGATCTTGACAGCTTGGGAGTTCTTATTTGTTACATGCACAACAAAATCCACTCCGCCAAGATGTCTCCTTTATCGATAGTTACAGCCCTG GTGGATAAGATTGATATGTGTAAGAAGAGCTTGAGCCCAGAACAGGACATTAAGTTCAGTGGCCATGTTAGCTGGGTCGGGAAGACATCCATGGAAGTGAAGATGCAAATGTTCCAGGAAACGTACTCCCAAACTAAGCCCAAGATGCAA AGTTTGGTTCAATGGGGGTTAGACAGCTATGACTATCTCCAAAATGCACCTCCTGGATTTTTTCCGAGACTTGGTGTTATTGGTTTTGCTGGCCTTATTGGACTCCTTTTGGCTAGAGGTTCAAAAATAAAGAAGCTAGTGTATCCGCCT GGTTTCATGGGATTAGCTGCCTCCCTCTATTATCCACAACAAGCCATCGTGTTTGCCCAGGTCAGTGGGGAGAGATTATATGACTGGGGTTTACGAGGATATATAGTCATAGAAGATTTGTGGAAGGAGAACTTTCAAAAGCCAGGAAAT GTGAAGAATTCACCTGGAACTAAGTAGAAAACTCCATGCTCTGCCATCTTAATCAGTTATAGGTAAACATTGGAAACTCCATAGAATAAATCAGTATTTCTACAGAAAAATGGCATAGAAGTCAGTATTGAATGTATTAAATTGGCTTTC TTCTTCAGGAAAAACTAGACCAGACCTCTGTTATCTTCTGTGAAATCATCCTACAAGCAAACTAACCTGGAATCCCTTCACCTAGAGATAATGTACAAGCCTTAGAACTCCTCATTCTCATGTTGCTATTTATGTACCTAATTAAAACCC AAGTTAAAAAAAAAAA >ACOT9_APOO_ENST00000379303_ENST00000379226_23739997_23899069 length=1594nt Breakpoint=717nt GTCCGGCTCCCGGGCTGTCCTCAGCAAGGGCGCGGTCTGGTACTCGTGCGTCTTTTATCGCCTCAGTTTCCCTCCGCCGACTAGCGCGCGGGGCCCGGTTCTCCATCGCGCGCACGGCAGCCTAGCGCAATGAGGCGGGCAGCACTGCGG CTTTGTGCCTTGGGCAAAGGGCAGCTTACTCCTGGAAGAGGACTGACTCAAGGACCCCAGAACCCCAAGAAACAGGGAATCTTCCACATTCATGAAGCATGTTCATCTATACATGTGAATCATGTTCGAGATAAGTTGCGGGAGATAGTA GGAGCATCCACAAACTGGAGAGACCATGTGAAGGCAATGGAAGAAAGGAAATTACTTCATAGTTTCTTGGCTAAATCACAGGATGGACTGCCTCCTAGGAGAATGAAGGACAGTTATATTGAAGTTCTCTTGCCTTTGGGCAGTGAGCCT GAATTACGAGAGAAATATTTGACTGTTCAAAACACCGTAAGATTTGGCAGGATTCTTGAGGATCTTGACAGCTTGGGAGTTCTTATTTGTTACATGCACAACAAAATCCACTCCGCCAAGATGTCTCCTTTATCGATAGTTACAGCCCTG GTGGATAAGATTGATATGTGTAAGAAGAGCTTGAGCCCAGAACAGGACATTAAGTTCAGTGGCCATGTTAGCTGGGTCGGGAAGACATCCATGGAAGTGAAGATGCAAATGTTCCAGGTAATTCAGAGGTCCGTGGGGCCAGCCAGCCTG AGCTTGCTCACCTTCAAAGTCTATGCAGCACCAAAAAAGGACTCACCTCCCAAAAATTCCGTGAAGGTTGATGAGCTTTCACTCTACTCAGTTCCTGAGGGTCAATCGAAGTATGTGGAGGAGGCAAGGAGCCAGCTTGAAGAAAGCATC TCACAGCTCCGACACTATTGCGAGCCATACACAACCTGGTGTCAGGAAACGTACTCCCAAACTAAGCCCAAGATGCAAAGTTTGGTTCAATGGGGGTTAGACAGCTATGACTATCTCCAAAATGCACCTCCTGGATTTTTTCCGAGACTT GGTGTTATTGGTTTTGCTGGCCTTATTGGACTCCTTTTGGCTAGAGGTTCAAAAATAAAGAAGCTAGTGTATCCGCCTGGTTTCATGGGATTAGCTGCCTCCCTCTATTATCCACAACAAGCCATCGTGTTTGCCCAGGTCAGTGGGGAG AGATTATATGACTGGGGTTTACGAGGATATATAGTCATAGAAGATTTGTGGAAGGAGAACTTTCAAAAGCCAGGAAATGTGAAGAATTCACCTGGAACTAAGTAGAAAACTCCATGCTCTGCCATCTTAATCAGTTATAGGTAAACATTG GAAACTCCATAGAATAAATCAGTATTTCTACAGAAAAATGGCATAGAAGTCAGTATTGAATGTATTAAATTGGCTTTCTTCTTCAGGAAAAACTAGACCAGACCTCTGTTATCTTCTGTGAAATCATCCTACAAGCAAACTAACCTGGAA TCCCTTCACCTAGAGATAATGTACAAGCCTTAGAACTCCTCATTCTCATGTTGCTATTTATGTACCTAATTAAAACCCAAGTTAAAAAAAAAAA >ACOT9_APOO_ENST00000379303_ENST00000379226_23748643_23886805 length=1123nt Breakpoint=529nt GTCCGGCTCCCGGGCTGTCCTCAGCAAGGGCGCGGTCTGGTACTCGTGCGTCTTTTATCGCCTCAGTTTCCCTCCGCCGACTAGCGCGCGGGGCCCGGTTCTCCATCGCGCGCACGGCAGCCTAGCGCAATGAGGCGGGCAGCACTGCGG CTTTGTGCCTTGGGCAAAGGGCAGCTTACTCCTGGAAGAGGACTGACTCAAGGACCCCAGAACCCCAAGAAACAGGGAATCTTCCACATTCATGAAGCATGTTCATCTATACATGTGAATCATGTTCGAGATAAGTTGCGGGAGATAGTA GGAGCATCCACAAACTGGAGAGACCATGTGAAGGCAATGGAAGAAAGGAAATTACTTCATAGTTTCTTGGCTAAATCACAGGATGGACTGCCTCCTAGGAGAATGAAGGACAGTTATATTGAAGTTCTCTTGCCTTTGGGCAGTGAGCCT GAATTACGAGAGAAATATTTGACTGTTCAAAACACCGTAAGATTTGGCAGGATTCTTGAGGATCTTGACAGCTTGGGAGACAGCTATGACTATCTCCAAAATGCACCTCCTGGATTTTTTCCGAGACTTGGTGTTATTGGTTTTGCTGGC CTTATTGGACTCCTTTTGGCTAGAGGTTCAAAAATAAAGAAGCTAGTGTATCCGCCTGGTTTCATGGGATTAGCTGCCTCCCTCTATTATCCACAACAAGCCATCGTGTTTGCCCAGGTCAGTGGGGAGAGATTATATGACTGGGGTTTA CGAGGATATATAGTCATAGAAGATTTGTGGAAGGAGAACTTTCAAAAGCCAGGAAATGTGAAGAATTCACCTGGAACTAAGTAGAAAACTCCATGCTCTGCCATCTTAATCAGTTATAGGTAAACATTGGAAACTCCATAGAATAAATCA GTATTTCTACAGAAAAATGGCATAGAAGTCAGTATTGAATGTATTAAATTGGCTTTCTTCTTCAGGAAAAACTAGACCAGACCTCTGTTATCTTCTGTGAAATCATCCTACAAGCAAACTAACCTGGAATCCCTTCACCTAGAGATAATG TACAAGCCTTAGAACTCCTCATTCTCATGTTGCTATTTATGTACCTAATTAAAACCCAAGTTAAAAAAAAAAA |
| N-Truncated Transcript (5UTR-3CDS) Sequences |
>ACOT9_APOO_ENST00000492081_ENST00000379226_23761241_23876850 length=498nt Breakpoint=0nt GTTCAAAAATAAAGAAGCTAGTGTATCCGCCTGGTTTCATGGGATTAGCTGCCTCCCTCTATTATCCACAACAAGCCATCGTGTTTGCCCAGGTCAGTGGGGAGAGATTATATGACTGGGGTTTACGAGGATATATAGTCATAGAAGATT TGTGGAAGGAGAACTTTCAAAAGCCAGGAAATGTGAAGAATTCACCTGGAACTAAGTAGAAAACTCCATGCTCTGCCATCTTAATCAGTTATAGGTAAACATTGGAAACTCCATAGAATAAATCAGTATTTCTACAGAAAAATGGCATAG AAGTCAGTATTGAATGTATTAAATTGGCTTTCTTCTTCAGGAAAAACTAGACCAGACCTCTGTTATCTTCTGTGAAATCATCCTACAAGCAAACTAACCTGGAATCCCTTCACCTAGAGATAATGTACAAGCCTTAGAACTCCTCATTCT CATGTTGCTATTTATGTACCTAATTAAAACCCAAGTTAAAAAAAAAAA |
| C-Truncated Transcript (5CDS-3UTR) Sequences |
>ACOT9_APOO_ENST00000336430_ENST00000379220_23748643_23851729 length=505nt Breakpoint=505nt GCTGTCCGGCTCCCGGGCTGTCCTCAGCAAGGGCGCGGTCTGGTACTCGTGCGTCTTTTATCGCCTCAGTTTCCCTCCGCCGACTAGCGCGCGGGGCCCGGTTCTCCATCGCGCGCACGGCAGCCTAGCGCAATGAGGCGGGCAGCACTG CGGCTTTGTGCCTTGGGCAAAGGGCAGCTTACTCCTGGAAGAGGACTGACTCAAGGACCCCAGAACCCCAAGAAACAGGGAATCTTCCACATTCATGAAGTTCGAGATAAGTTGCGGGAGATAGTAGGAGCATCCACAAACTGGAGAGAC CATGTGAAGGCAATGGAAGAAAGGAAATTACTTCATAGTTTCTTGGCTAAATCACAGGATGGACTGCCTCCTAGGAGAATGAAGGACAGTTATATTGAAGTTCTCTTGCCTTTGGGCAGTGAGCCTGAATTACGAGAGAAATATTTGACT GTTCAAAACACCGTAAGATTTGGCAGGATTCTTGAGGATCTTGACAGCTTGGGAG >ACOT9_APOO_ENST00000336430_ENST00000379226_23748643_23851729 length=505nt Breakpoint=505nt GCTGTCCGGCTCCCGGGCTGTCCTCAGCAAGGGCGCGGTCTGGTACTCGTGCGTCTTTTATCGCCTCAGTTTCCCTCCGCCGACTAGCGCGCGGGGCCCGGTTCTCCATCGCGCGCACGGCAGCCTAGCGCAATGAGGCGGGCAGCACTG CGGCTTTGTGCCTTGGGCAAAGGGCAGCTTACTCCTGGAAGAGGACTGACTCAAGGACCCCAGAACCCCAAGAAACAGGGAATCTTCCACATTCATGAAGTTCGAGATAAGTTGCGGGAGATAGTAGGAGCATCCACAAACTGGAGAGAC CATGTGAAGGCAATGGAAGAAAGGAAATTACTTCATAGTTTCTTGGCTAAATCACAGGATGGACTGCCTCCTAGGAGAATGAAGGACAGTTATATTGAAGTTCTCTTGCCTTTGGGCAGTGAGCCTGAATTACGAGAGAAATATTTGACT GTTCAAAACACCGTAAGATTTGGCAGGATTCTTGAGGATCTTGACAGCTTGGGAG >ACOT9_APOO_ENST00000379295_ENST00000379220_23748643_23851729 length=1611nt Breakpoint=1611nt AAGAGCAGTAACACAAACAGGGCTGAAACACGCCCTCCTCCCGTCCCCACACCCCCGCGACTTGCCATGTTGCGGGTGATGTGAAGGAGAGAAGTGCTGTGGCCCTTCAGGGAGCACAGACCTAGGGGCTCCCTGAGCCAGGGCTGTGAC ACCCTCTTTGGGGCTCTGCGGTTTCTGGTATCTTCAAACTTCCGGGCACCACTGCATTCCCCTTGTCCAGACACAGGTGCCCACAGCAGAAGCCGCTTGTGGTTCATCAGATCCAGCTGCAGACTTGCATAGAACCGGCACCTTTGCCGG CGCCTGGAGCTGCCTGCCCAGCTGCAGCAGCTGGTGTGTCCGGCTCTGCGCAGTGGCCAGACCCTGCGTTCGCTCGCCTGCACACCCCTCGCTGTTCCGTGCCTGGCTCACCCTCGGCAGGCGTGGAATCCTGGCTGGTAGCATGAGCTG AGCACAGCCTGCCAGGCCACGTCAGTGGAACAAGTCTGGCGGGCCTGATCAAAACTCAGGCAAAGGCACCACTGGTCACAGAGCTTTCTAGCTGGAAAAGCAACACCTGAAGGATCCCGTGACACAATCAACCTGCTAGGAGATCCCTGC CACCCTGAGAGGCTGCAGGAAGCTGCCTCCATCCAGGCCTCTTCACAGAAGGAGAATTGCAGAGACCGTAGGATTTTTCTACTCACAGGAACAGATGGTGTCCGGTCAGGAAGGTAAAATGCTTCAAGAAAAGTGCAATAGGGATTATAA TACTGATGATCTGAGACTCTGATAATGACTCTGAGATGATTCCCAATTCTATGATGAATCATCTCAGAATGACTCCGAGATGATGATTCCTGATTCTACGATGATTGAGGCAGAGCTCACTGGTTGGTGAATCTAGTTGGTAGAGCTGAG GCACCGCAATACCATCATTTCTTTCTGAGGAAATCTAAAGATGAAAGAATTCATCACTAAAACTGTACTACGAGAAATGCTAAAGGAAGTTGTTCAAACTGATGGAAAATTATACCAGATGGACACTTGAATTTGCCCAAAGGAATGAAG AGCACCAGAAATGGCAAATGTGTGGTCTTACTGTATCTTCATGTCAGTGTCATATCAAGGACAAGACAGCAGAAATGGTCCACTCCAGTTGCAGATAGTAAAGACCCTGTAGCTCCAGCATCAGCTCACCTTTCTGGTTTTGAATTTCAT GCTTATTACCATCCTGTCATCACCTACTGTTTCCATGGTAGACGGGACTAAGAGATGGGCTTTGTGCCTTGGGCAAAGGGCAGCTTACTCCTGGAAGAGGACTGACTCAAGGACCCCAGAACCCCAAGAAACAGGGAATCTTCCACATTC ATGAAGTTCGAGATAAGTTGCGGGAGATAGTAGGAGCATCCACAAACTGGAGAGACCATGTGAAGGCAATGGAAGAAAGGAAATTACTTCATAGTTTCTTGGCTAAATCACAGGATGGACTGCCTCCTAGGAGAATGAAGGACAGTTATA TTGAAGTTCTCTTGCCTTTGGGCAGTGAGCCTGAATTACGAGAGAAATATTTGACTGTTCAAAACACCGTAAGATTTGGCAGGATTCTTGAGGATCTTGACAGCTTGGGAG >ACOT9_APOO_ENST00000379295_ENST00000379226_23748643_23851729 length=1611nt Breakpoint=1611nt AAGAGCAGTAACACAAACAGGGCTGAAACACGCCCTCCTCCCGTCCCCACACCCCCGCGACTTGCCATGTTGCGGGTGATGTGAAGGAGAGAAGTGCTGTGGCCCTTCAGGGAGCACAGACCTAGGGGCTCCCTGAGCCAGGGCTGTGAC ACCCTCTTTGGGGCTCTGCGGTTTCTGGTATCTTCAAACTTCCGGGCACCACTGCATTCCCCTTGTCCAGACACAGGTGCCCACAGCAGAAGCCGCTTGTGGTTCATCAGATCCAGCTGCAGACTTGCATAGAACCGGCACCTTTGCCGG CGCCTGGAGCTGCCTGCCCAGCTGCAGCAGCTGGTGTGTCCGGCTCTGCGCAGTGGCCAGACCCTGCGTTCGCTCGCCTGCACACCCCTCGCTGTTCCGTGCCTGGCTCACCCTCGGCAGGCGTGGAATCCTGGCTGGTAGCATGAGCTG AGCACAGCCTGCCAGGCCACGTCAGTGGAACAAGTCTGGCGGGCCTGATCAAAACTCAGGCAAAGGCACCACTGGTCACAGAGCTTTCTAGCTGGAAAAGCAACACCTGAAGGATCCCGTGACACAATCAACCTGCTAGGAGATCCCTGC CACCCTGAGAGGCTGCAGGAAGCTGCCTCCATCCAGGCCTCTTCACAGAAGGAGAATTGCAGAGACCGTAGGATTTTTCTACTCACAGGAACAGATGGTGTCCGGTCAGGAAGGTAAAATGCTTCAAGAAAAGTGCAATAGGGATTATAA TACTGATGATCTGAGACTCTGATAATGACTCTGAGATGATTCCCAATTCTATGATGAATCATCTCAGAATGACTCCGAGATGATGATTCCTGATTCTACGATGATTGAGGCAGAGCTCACTGGTTGGTGAATCTAGTTGGTAGAGCTGAG GCACCGCAATACCATCATTTCTTTCTGAGGAAATCTAAAGATGAAAGAATTCATCACTAAAACTGTACTACGAGAAATGCTAAAGGAAGTTGTTCAAACTGATGGAAAATTATACCAGATGGACACTTGAATTTGCCCAAAGGAATGAAG AGCACCAGAAATGGCAAATGTGTGGTCTTACTGTATCTTCATGTCAGTGTCATATCAAGGACAAGACAGCAGAAATGGTCCACTCCAGTTGCAGATAGTAAAGACCCTGTAGCTCCAGCATCAGCTCACCTTTCTGGTTTTGAATTTCAT GCTTATTACCATCCTGTCATCACCTACTGTTTCCATGGTAGACGGGACTAAGAGATGGGCTTTGTGCCTTGGGCAAAGGGCAGCTTACTCCTGGAAGAGGACTGACTCAAGGACCCCAGAACCCCAAGAAACAGGGAATCTTCCACATTC ATGAAGTTCGAGATAAGTTGCGGGAGATAGTAGGAGCATCCACAAACTGGAGAGACCATGTGAAGGCAATGGAAGAAAGGAAATTACTTCATAGTTTCTTGGCTAAATCACAGGATGGACTGCCTCCTAGGAGAATGAAGGACAGTTATA TTGAAGTTCTCTTGCCTTTGGGCAGTGAGCCTGAATTACGAGAGAAATATTTGACTGTTCAAAACACCGTAAGATTTGGCAGGATTCTTGAGGATCTTGACAGCTTGGGAG >ACOT9_APOO_ENST00000379303_ENST00000379220_23748643_23851729 length=529nt Breakpoint=529nt GTCCGGCTCCCGGGCTGTCCTCAGCAAGGGCGCGGTCTGGTACTCGTGCGTCTTTTATCGCCTCAGTTTCCCTCCGCCGACTAGCGCGCGGGGCCCGGTTCTCCATCGCGCGCACGGCAGCCTAGCGCAATGAGGCGGGCAGCACTGCGG CTTTGTGCCTTGGGCAAAGGGCAGCTTACTCCTGGAAGAGGACTGACTCAAGGACCCCAGAACCCCAAGAAACAGGGAATCTTCCACATTCATGAAGCATGTTCATCTATACATGTGAATCATGTTCGAGATAAGTTGCGGGAGATAGTA GGAGCATCCACAAACTGGAGAGACCATGTGAAGGCAATGGAAGAAAGGAAATTACTTCATAGTTTCTTGGCTAAATCACAGGATGGACTGCCTCCTAGGAGAATGAAGGACAGTTATATTGAAGTTCTCTTGCCTTTGGGCAGTGAGCCT GAATTACGAGAGAAATATTTGACTGTTCAAAACACCGTAAGATTTGGCAGGATTCTTGAGGATCTTGACAGCTTGGGAG >ACOT9_APOO_ENST00000379303_ENST00000379226_23748643_23851729 length=529nt Breakpoint=529nt GTCCGGCTCCCGGGCTGTCCTCAGCAAGGGCGCGGTCTGGTACTCGTGCGTCTTTTATCGCCTCAGTTTCCCTCCGCCGACTAGCGCGCGGGGCCCGGTTCTCCATCGCGCGCACGGCAGCCTAGCGCAATGAGGCGGGCAGCACTGCGG CTTTGTGCCTTGGGCAAAGGGCAGCTTACTCCTGGAAGAGGACTGACTCAAGGACCCCAGAACCCCAAGAAACAGGGAATCTTCCACATTCATGAAGCATGTTCATCTATACATGTGAATCATGTTCGAGATAAGTTGCGGGAGATAGTA GGAGCATCCACAAACTGGAGAGACCATGTGAAGGCAATGGAAGAAAGGAAATTACTTCATAGTTTCTTGGCTAAATCACAGGATGGACTGCCTCCTAGGAGAATGAAGGACAGTTATATTGAAGTTCTCTTGCCTTTGGGCAGTGAGCCT GAATTACGAGAGAAATATTTGACTGTTCAAAACACCGTAAGATTTGGCAGGATTCTTGAGGATCTTGACAGCTTGGGAG >ACOT9_APOO_ENST00000492081_ENST00000379220_23748643_23851729 length=381nt Breakpoint=381nt GCAAGGGCGCGGTCTGGTACTCGTGCGTCTTTTATCGCCTCAGTTTCCCTCCGCCGACTAGCGCGCGGGGCCCGGTTCTCCATCGCGCGCACGGCAGCCTAGCGCAATGAGGCGGGCAGCACTGCGTTCGAGATAAGTTGCGGGAGATAG TAGGAGCATCCACAAACTGGAGAGACCATGTGAAGGCAATGGAAGAAAGGAAATTACTTCATAGTTTCTTGGCTAAATCACAGGATGGACTGCCTCCTAGGAGAATGAAGGACAGTTATATTGAAGTTCTCTTGCCTTTGGGCAGTGAGC CTGAATTACGAGAGAAATATTTGACTGTTCAAAACACCGTAAGATTTGGCAGGATTCTTGAGGATCTTGACAGCTTGGGAG >ACOT9_APOO_ENST00000492081_ENST00000379226_23748643_23851729 length=381nt Breakpoint=381nt GCAAGGGCGCGGTCTGGTACTCGTGCGTCTTTTATCGCCTCAGTTTCCCTCCGCCGACTAGCGCGCGGGGCCCGGTTCTCCATCGCGCGCACGGCAGCCTAGCGCAATGAGGCGGGCAGCACTGCGTTCGAGATAAGTTGCGGGAGATAG TAGGAGCATCCACAAACTGGAGAGACCATGTGAAGGCAATGGAAGAAAGGAAATTACTTCATAGTTTCTTGGCTAAATCACAGGATGGACTGCCTCCTAGGAGAATGAAGGACAGTTATATTGAAGTTCTCTTGCCTTTGGGCAGTGAGC CTGAATTACGAGAGAAATATTTGACTGTTCAAAACACCGTAAGATTTGGCAGGATTCTTGAGGATCTTGACAGCTTGGGAG |
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Fusion Protein Sequence for ACOT9_APOO |
| In-frame Fusion Protein Sequences. |
>ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23892574 length=315nt MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQETYSQTKPKMQSLVQWGLDSYDYLQNAPPGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKE NFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069 length=391nt MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23748643_23886805 length=234nt MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGDSYDYLQNAPPGFFPRL GVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000379303_ENST00000379226_23739997_23892574 length=979nt MAAASGGSRQETWGDDAPASEKLVTKRPQKGSRQGLFWGEGQTDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGT GPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGH EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKL SDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVI RPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDS GPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSW DCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV >ACOT9_APOO_ENST00000379303_ENST00000379226_23739997_23899069 length=561nt MRATGAGVGWGRGWESGPTARSPGRAFRSDLIRPPRHWARQRIGGAGGRERPAQIFTAARRVRAQVRPAPPLRPPQTLPSGLPPGRARLPRLAGLPRTGAAQPPPNLLEAAAAWAPTPPESYARASSLQPWRPGRRGSGWGRRGGGVGAG RPRSIAPGAQAPPHQPHRSTSALPLYGAARAHSFRAGPARHLRPSAAARRIRRRSPQHVGPRRRDAVRHPDLPEAVDDIVSALKLGPGTVVPELRSLKPEAQALITQGLYSHCRALLSQLPDTGAPLEDKDTQGLLAVGEALIKIDSGQP HWHLLLADILMAQGSYEEAGTHLEKALHRAPTSEAARARLGLLQLKKGDVPGAARDLQSLAEVDAPDLSCLLHLLEASERQSLAQAAAQEAGTLLDAGQPRQALGYCSLSVLASGSSACHLRLRATCLAELQEFGRALRDLDHVLQEALG DGDLPRRAEDFCRQGRLLLSLGDEAAAAGAFAQALKLAPSLAQNSLCRQPGRAPTARMFLLRGQCCLEEQRHAEAWTAVESGLLVDPDHRGLKRLKARIRREASSGCWLQX >ACOT9_APOO_ENST00000379303_ENST00000379226_23748643_23886805 length=182nt MDVNGGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRFHIGNEKQNYRLYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQ NHGKLNGIKWHYFKGPSYSLRSTTMMIRPLDF |
| N-Truncated Protein (5UTR-3CDS) Sequences |
>ACOT9_APOO_ENST00000492081_ENST00000379226_23761241_23876850 length=113nt MLLELLVVTSIIVSLYQVITICFPLSPLVAWEPLRGKHSPHTGMGCLQSCITPLFCLKNKTTLYKGKEWFIFSPQQRCPMWKWQKKDQSLAGNVGNHLPLSCNTILAVPLPSL |
| C-Truncated Protein (5CDS-3UTR) Sequences |
Top |
Personalized Fusion Protein Sequence for ACOT9_APOO |
| TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| TCGA All Mutated Fusion Protein Sequences |
>ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.G196A_391_G389A length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPATK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.V35M_391_V228M length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSMKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.I117S;p.G124V_391_I310S;G317V length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVSGFAGLIVLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.P11S_391_P204S length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGSASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.V45L_391_V238L length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSLPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.Q59R_391_Q252R length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSRLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.Q104L_391_Q297L length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLLNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.Q160H_391_Q353H length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAHVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.V157M_391_V350M length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIMFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.Y138H_391_Y331H length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVHPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.S99I_391_S292I length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDIYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.F142Y_391_F335Y length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGYMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.N184I_391_N377I length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKEIFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.P139L_391_P332L length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYLPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.P195S_391_P388S length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSSGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.P139L_391_P332L length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYLPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.I5F_391_I198F length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVFQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.S50L_391_S243L length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQLKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.Q79H_391_Q272H length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCHETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.G48C_391_G241C length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPECQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.R7K_391_R200K length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQKSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.P139L_391_P332L length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYLPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.P139L_391_P332L length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYLPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.D38N_391_D231N length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVNELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.A128P_391_A321P length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLPRGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.D38Y_391_D231Y length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVYELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.V161I_391_V354I length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQISGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.T18N_391_T211N length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLNFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.C78Y_391_C271Y length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWYQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23739997_23899069_3-gene_p.V157M_391_V350M length=391AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSP LSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAP PGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIMFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-09-2049-01D | 3-gene | p.G196A | 391 | G389A |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-13-1500-01A | 3-gene | p.V35M | 391 | V228M |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-22-4601-01A | 3-gene | p.I117S;p.G124V | 391 | I310S;G317V |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-41-4097-01A | 3-gene | p.P11S | 391 | P204S |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-44-7660-01A | 3-gene | p.V45L | 391 | V238L |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-52-7809-01A | 3-gene | p.Q59R | 391 | Q252R |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-85-7710-01A | 3-gene | p.Q104L | 391 | Q297L |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-A5-A0G2-01A | 3-gene | p.Q160H | 391 | Q353H |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-A5-A1OF-01A | 3-gene | p.V157M | 391 | V350M |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-A8-A094-01A | 3-gene | p.Y138H | 391 | Y331H |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-AP-A1DV-01A | 3-gene | p.S99I | 391 | S292I |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-B5-A1MR-01A | 3-gene | p.F142Y | 391 | F335Y |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-CJ-5672-01A | 3-gene | p.N184I | 391 | N377I |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-D3-A5GN-06A | 3-gene | p.P139L | 391 | P332L |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-DF-A2KN-01A | 3-gene | p.P195S | 391 | P388S |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-DF-A2KU-01A | 3-gene | p.P139L | 391 | P332L |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-DU-8158-01A | 3-gene | p.I5F | 391 | I198F |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-E6-A1LX-01A | 3-gene | p.S50L | 391 | S243L |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-EB-A5UL-06A | 3-gene | p.Q79H | 391 | Q272H |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-EE-A181-06A | 3-gene | p.G48C | 391 | G241C |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-EE-A3JI-06A | 3-gene | p.R7K | 391 | R200K |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-EJ-7782-01A | 3-gene | p.P139L | 391 | P332L |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-EO-A22U-01A | 3-gene | p.P139L | 391 | P332L |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-G2-A2EJ-01A | 3-gene | p.D38N | 391 | D231N |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-LL-A8F5-01A | 3-gene | p.A128P | 391 | A321P |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-O2-A52Q-01A | 3-gene | p.D38Y | 391 | D231Y |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-W3-A825-06A | 3-gene | p.V161I | 391 | V354I |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-WY-A859-01A | 3-gene | p.T18N | 391 | T211N |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-XF-A9SI-01A | 3-gene | p.C78Y | 391 | C271Y |
| ENST00000336430_ENST00000379226_23739997_23899069 | TCGA-XK-AAIW-01A | 3-gene | p.V157M | 391 | V350M |
| CCLE All Mutated Fusion Protein Sequences |
>ACOT9_APOO_ENST00000336430_ENST00000379226_23748643_23886805_3-gene_p.L103P_234_L139P length=234AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGDSYDYPQNAPPGFFPRL GVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK >ACOT9_APOO_ENST00000336430_ENST00000379226_23748643_23886805_3-gene_p.G189E_234_G225E length=234AA MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGDSYDYLQNAPPGFFPRL GVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPENVKNSPGTK |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
| ENST00000336430_ENST00000379226_23748643_23886805 | ACH-000011 | 3-gene | p.L103P | 234 | L139P |
| ENST00000336430_ENST00000379226_23748643_23886805 | ACH-002005 | 3-gene | p.G189E | 234 | G225E |
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Fusion Gene Exprssed Samples for ACOT9_APOO |
| RNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| CCLE | Lung Squamous Cell Carcinoma | HCC2814 | ACOT9 | chrX | 23761242 | - | APOO | chrX | 23876850 | - | |
| CCLE | Oral Cavity Squamous Cell Carcinoma | UPCISCC131 | ACOT9 | chrX | 23748644 | - | APOO | chrX | 23886805 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01A | ACOT9 | chrX | 23731251 | - | APOO | chrX | 23899069 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01A | ACOT9 | chrX | 23731251 | - | APOO | chrX | 23899069 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01A | ACOT9 | chrX | 23739997 | - | APOO | chrX | 23899068 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01A | ACOT9 | chrX | 23739997 | - | APOO | chrX | 23899069 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01A | ACOT9 | chrX | 23739997 | - | APOO | chrX | 23899069 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01A | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851626 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01A | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851627 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01A | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851627 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01A | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851728 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01A | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851729 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01A | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851729 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01A | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851626 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01A | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851627 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01A | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851627 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01A | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851728 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01A | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851729 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01A | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851729 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01B | ACOT9 | chrX | 23731251 | - | APOO | chrX | 23899069 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01B | ACOT9 | chrX | 23739997 | - | APOO | chrX | 23899069 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01B | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851627 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01B | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851729 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01B | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851627 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D-01B | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851729 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D | ACOT9 | chrX | 23731251 | - | APOO | chrX | 23899069 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D | ACOT9 | chrX | 23739997 | - | APOO | chrX | 23899069 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851627 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D | ACOT9 | chrX | 23748643 | - | APOO | chrX | 23851729 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851627 | - | |
| ChimerDB | BRCA | TCGA-A7-A13D | ACOT9 | chrX | 23761241 | - | APOO | chrX | 23851729 | - | |
| ChimerDB | BRCA | TCGA-AC-A8OQ-01A | ACOT9 | chrX | 23739997 | - | APOO | chrX | 23899069 | - | |
| ChimerDB | CESC | TCGA-DG-A2KH-01A | ACOT9 | chrX | 23721940 | - | APOO | chrX | 23876850 | - | |
| ChimerDB | CESC | TCGA-DG-A2KH-01A | ACOT9 | chrX | 23721965 | - | APOO | chrX | 23876850 | - | |
| ChimerDB | LUAD | TCGA-05-5423-01A | ACOT9 | chrX | 23739997 | - | APOO | chrX | 23899069 | - | |
| ChimerDB | LUAD | TCGA-05-5423-01A | ACOT9 | chrX | 23739997 | - | APOO | chrX | 23899069 | - | |
| ChimerDB | LUAD | TCGA-05-5423 | ACOT9 | chrX | 23739997 | - | APOO | chrX | 23899069 | - | |
| ChimerDB | LUSC | TCGA-43-A56U-01A | ACOT9 | chrX | 23739997 | - | APOO | chrX | 23899069 | - | |
| ChimerDB | LUSC | TCGA-43-A56U-01A | ACOT9 | chrX | 23739997 | - | APOO | chrX | 23899069 | - | |
| ChimerDB | LUSC | TCGA-43-A56U | ACOT9 | chrX | 23739997 | - | APOO | chrX | 23899069 | - | |
| ChimerDB | LUSC | TCGA-98-A53A-01A | ACOT9 | chrX | 23739997 | - | APOO | chrX | 23899069 | - | |
| TCGAfusionPortal | BRCA | TCGA-A7-A13D-01A | ACOT9 | chrX | 23739997 | - | APOO | chrX | 23899069 | - | |
| cBioPortal | CCLE_GENENTECH_2014 | MIXED | S-OvCA-432 | ACOT9 | chrX | 23739998 | APOO | chrX | 23892574 |
| DNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | SV type |
| dbVar | nstd132 | Whole blood | CGPQ-229 | ACOT9 | chrX | 23761122 | APOO | chrX | 23862997 | DEL |
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Related Drugs for ACOT9_APOO |
| PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug'] * For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub. |
| PMID | Fusion Gene Name | Drug | Study Title |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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