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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene Breakpoints

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness

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Fusion Genomic Features

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Fusion Gene ORF Annotations

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Fusion Protein Retained/Non-Retained Functional Features

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Fusion Transcript Sequences

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Fusion Protein Sequences

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Personalized Fusion Protein Sequences

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Fusion Gene Expressed Samples

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Related Drugs

Fusion gene:CORO1C_PACRG (FusionGDB2 ID:HG23603TG135138)

Fusion Gene Summary for CORO1C_PACRG

check button Fusion gene summary
Fusion gene informationFusion gene name: CORO1C_PACRG
Fusion gene ID: hg23603tg135138
HgeneTgene
Gene symbol

CORO1C

PACRG

Gene ID

23603

135138

Gene namecoronin 1Cparkin coregulated
SynonymsHCRNN4BUG21|GLUP|HAK005771|PACRG2.1|PARK2CRG|pf12
Cytomap

12q24.11

6q26

Type of geneprotein-codingprotein-coding
Descriptioncoronin-1Ccoronin, actin binding protein, 1Ccoronin-3parkin coregulated gene proteinPARK2 co-regulatedPARK2 coregulatedmolecular chaperone/chaperonin-binding proteinparkin co-regulated gene protein
Modification date2024040720240411
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000261401, ENST00000549384, 
ENST00000420959, ENST00000421578, 
ENST00000541050, ENST00000549772, 
Fusion gene scores* DoF score* DoF score (Degree of Frequency) = # partners X # break points X # disease types
22 X 19 X 16=6688
* DoF score (Degree of Frequency) = # partners X # break points X # disease types
6 X 29 X 22=3828
# samples 22747
** MAII score** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)
log2(227/6688*10)=-1.55888254990261
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)
log2(47/3828*10)=-3.02585816792103
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CORO1C [Title/Abstract] AND PACRG [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCORO1C(109125204)-PACRG(163735858), # samples:1


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Fusion Gene Breakpoints for CORO1C_PACRG


check button RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.
HgeneHchrHbpTgeneTchrTbp
CORO1Cchr12109125204PACRGchr6109125204
CORO1Cchr12109125205PACRGchr6163735859
CORO1Cchr12108731429PACRGchr6163314827


check button DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.
HgeneHchrHbpTgeneTchrTbpSV type


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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for CORO1C_PACRG


check button To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.
* We have 10 tumorigenic mechanism categories of fusion genes as shown below.
Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand FusionsAberrant Chimeric Transcription Factor / Fusion Transcription Factor ActivityEpigenetic Reprogramming / Histone Modifier DysregulationChromatin Remodeling DysregulationCondensate-Driven Transcriptional Rewiring / LLPPromoter / Enhancer HijackingDominant-Negative AntagonismCell Cycle / Checkpoint Bypass / RNA Processing DysregulationSubcellular Mislocalization / Spatial DysregulationNuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.
Fusion Gene NameMechanism CategoryMechanism PubMedTumorigenic ScenariosTumorigenic Scenario PubMedTargeting PointsTargeting PubMedMechanism BackgroundMechanism Background PubMed

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.
Fusion Gene NameMechanism CategoryMechanism PubMedTumorigenic ScenariosTumorigenic Scenario PubMedTargeting PointsTargeting PubMedMechanism BackgroundMechanism Background PubMed

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCORO1C

GO:0016197

endosomal transport

30220460

HgeneCORO1C

GO:0090148

membrane fission

30220460

HgeneCORO1C

GO:0097750

endosome membrane tubulation

30220460

HgeneCORO1C

GO:0140285

endosome fission

30220460


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Fusion Genomic Features for CORO1C_PACRG


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CORO1Cchr12109125204-PACRGchr6163735858+1.46e-111.00e+00


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CORO1Cchr12109125204-PACRGchr6163735858+1.46e-111.00e+00

check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).
genomic feature

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Fusion Gene ORF Annotations for CORO1C_PACRG

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000261401ENST00000337019CORO1Cchr12

109125204

-PACRGchr6

163735858

+
5UTR-3CDSENST00000261401ENST00000366888CORO1Cchr12

109125204

-PACRGchr6

163735858

+
5UTR-3CDSENST00000261401ENST00000366889CORO1Cchr12

109125204

-PACRGchr6

163735858

+
5UTR-3CDSENST00000549384ENST00000337019CORO1Cchr12

109125204

-PACRGchr6

163735858

+
5UTR-3CDSENST00000549384ENST00000366888CORO1Cchr12

109125204

-PACRGchr6

163735858

+
5UTR-3CDSENST00000549384ENST00000366889CORO1Cchr12

109125204

-PACRGchr6

163735858

+

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)
Seq length
(peptide)

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)
Seq length
(peptide)

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)
Seq length
(peptide)

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score
ENST00000261401ENST00000337019CORO1Cchr12109125204PACRGchr61637358580.00e+004.53e-01
ENST00000261401ENST00000366888CORO1Cchr12109125204PACRGchr61637358580.00e+003.39e-01
ENST00000261401ENST00000366889CORO1Cchr12109125204PACRGchr61637358580.00e+004.49e-01
ENST00000549384ENST00000337019CORO1Cchr12109125204PACRGchr61637358580.00e+004.53e-01
ENST00000549384ENST00000366888CORO1Cchr12109125204PACRGchr61637358580.00e+003.39e-01
ENST00000549384ENST00000366889CORO1Cchr12109125204PACRGchr61637358580.00e+004.49e-01

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score

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Fusion Protein Retained/Non-Retained Functional Features for CORO1C_PACRG

check buttonProtein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.
fgviewer annotation
- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).
No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


check button - Retained PPIs in in-frame fusion.
PartnerHgeneHbpTgeneTbpENSTUniProtStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerHgeneHbpTgeneTbpENSTUniProtStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Fusion Transcript Sequence for CORO1C_PACRG

check button In-frame Fusion Transcript Sequences.

check button N-Truncated Transcript (5UTR-3CDS) Sequences
>CORO1C_PACRG_ENST00000261401_ENST00000337019_109125204_163735858 length=665nt
Breakpoint=0nt
TGAACTCCGGAGACGGCATTGACTACAGCCAGCAGAAGAGGGAGAACATTGGGGACTTGATCCAGGAGACACTGGAGGCCTTCGAGCGCTACGGAGGAGAAAATGCCTTTATCAACATTAAGTACGTGGTCCCAACCTACGAGTCTTGCT
TGCTAAACTAACAGTGGCAGCAGCTGGGACTTGAAACCTCCCGTTGGTGTTGGGATCATCTGTCTCTGTTGCTTTTAGCATCTCATTCCTTGTGACTTCCACAGCTTTCTTTTCTACAGCTGCTAAAATAGTGGCTTATGGGCCATTGGA
CTGTTAGCCCTATTGAGAGCAAGGCTTTCCAATACATAAATAGTGTCTGTTTCTTAGATTACAATAGTGTACTGTGCTTATTTGTTCTAAGAGAAGAATTGCTTCTTTATACAGCTCCGACAGAAGCAGGAGTCCGAGTTAAACCTTCAG
TTGTATAGACAATAAACTATAATTTTCATATGCAATTCAGCAATTGCTGTTCTGTGTGTGCCTGCCCTGGGGGTGATGTCAGAGGTTGTAAGGGAAGAGTTTATGCTGACTGCTTACTAGGTGTTTGTCATGGAAGAGAAGCATGGGTTC
AGCAGTGCCTCTCTAGCAGCTGTGCGGAATAATGTGCTTTGACATTCAATAAAACTGTTGAATCT

>CORO1C_PACRG_ENST00000261401_ENST00000366888_109125204_163735858 length=485nt
Breakpoint=0nt
TGAACTCCGGAGACGGCATTGACTACAGCCAGCAGAAGAGGGAGAACATTGGGGACTTGATCCAGGAGACACTGGAGGCCTTCGAGCGCTACGGAGGAGAAAATGCCTTTATCAACATTAAGTACGTGGTCCCAACCTACGAGTCTTGCT
TGCTAAACTAACAGTGGCAGCAGCTGGGACTTGAAACCTCCCGTTGGTGTTGGGATCATCTGTCTCTGTTGCTTTTAGCATCTCATTCCTTGTGACTTCCACAGCTTTCTTTTCTACAGCTGCTAAAATAGTGGCTTATGGGCCATTGGA
CTGTTAGCCCTATTGAGAGCAAGGCTTTCCAATACATAAATAGTGTCTGTTTCTTAGATTACAATAGTGTACTGTGCTTATTTGTTCTAAGAGAAGAATTGCTTCTTTATACAGCTCCGACAGAAGCAGGAGTCCGAGTTAAACCTTCAG
TTGTATAGACAATAAACTATAATTTTCATATGCAA

>CORO1C_PACRG_ENST00000261401_ENST00000366889_109125204_163735858 length=666nt
Breakpoint=0nt
TGAACTCCGGAGACGGCATTGACTACAGCCAGCAGAAGAGGGAGAACATTGGGGACTTGATCCAGGAGACACTGGAGGCCTTCGAGCGCTACGGAGGAGAAAATGCCTTTATCAACATTAAGTACGTGGTCCCAACCTACGAGTCTTGCT
TGCTAAACTAACAGTGGCAGCAGCTGGGACTTGAAACCTCCCGTTGGTGTTGGGATCATCTGTCTCTGTTGCTTTTAGCATCTCATTCCTTGTGACTTCCACAGCTTTCTTTTCTACAGCTGCTAAAATAGTGGCTTATGGGCCATTGGA
CTGTTAGCCCTATTGAGAGCAAGGCTTTCCAATACATAAATAGTGTCTGTTTCTTAGATTACAATAGTGTACTGTGCTTATTTGTTCTAAGAGAAGAATTGCTTCTTTATACAGCTCCGACAGAAGCAGGAGTCCGAGTTAAACCTTCAG
TTGTATAGACAATAAACTATAATTTTCATATGCAATTCAGCAATTGCTGTTCTGTGTGTGCCTGCCCTGGGGGTGATGTCAGAGGTTGTAAGGGAAGAGTTTATGCTGACTGCTTACTAGGTGTTTGTCATGGAAGAGAAGCATGGGTTC
AGCAGTGCCTCTCTAGCAGCTGTGCGGAATAATGTGCTTTGACATTCAATAAAACTGTTGAATCTA

>CORO1C_PACRG_ENST00000549384_ENST00000337019_109125204_163735858 length=665nt
Breakpoint=0nt
TGAACTCCGGAGACGGCATTGACTACAGCCAGCAGAAGAGGGAGAACATTGGGGACTTGATCCAGGAGACACTGGAGGCCTTCGAGCGCTACGGAGGAGAAAATGCCTTTATCAACATTAAGTACGTGGTCCCAACCTACGAGTCTTGCT
TGCTAAACTAACAGTGGCAGCAGCTGGGACTTGAAACCTCCCGTTGGTGTTGGGATCATCTGTCTCTGTTGCTTTTAGCATCTCATTCCTTGTGACTTCCACAGCTTTCTTTTCTACAGCTGCTAAAATAGTGGCTTATGGGCCATTGGA
CTGTTAGCCCTATTGAGAGCAAGGCTTTCCAATACATAAATAGTGTCTGTTTCTTAGATTACAATAGTGTACTGTGCTTATTTGTTCTAAGAGAAGAATTGCTTCTTTATACAGCTCCGACAGAAGCAGGAGTCCGAGTTAAACCTTCAG
TTGTATAGACAATAAACTATAATTTTCATATGCAATTCAGCAATTGCTGTTCTGTGTGTGCCTGCCCTGGGGGTGATGTCAGAGGTTGTAAGGGAAGAGTTTATGCTGACTGCTTACTAGGTGTTTGTCATGGAAGAGAAGCATGGGTTC
AGCAGTGCCTCTCTAGCAGCTGTGCGGAATAATGTGCTTTGACATTCAATAAAACTGTTGAATCT

>CORO1C_PACRG_ENST00000549384_ENST00000366888_109125204_163735858 length=485nt
Breakpoint=0nt
TGAACTCCGGAGACGGCATTGACTACAGCCAGCAGAAGAGGGAGAACATTGGGGACTTGATCCAGGAGACACTGGAGGCCTTCGAGCGCTACGGAGGAGAAAATGCCTTTATCAACATTAAGTACGTGGTCCCAACCTACGAGTCTTGCT
TGCTAAACTAACAGTGGCAGCAGCTGGGACTTGAAACCTCCCGTTGGTGTTGGGATCATCTGTCTCTGTTGCTTTTAGCATCTCATTCCTTGTGACTTCCACAGCTTTCTTTTCTACAGCTGCTAAAATAGTGGCTTATGGGCCATTGGA
CTGTTAGCCCTATTGAGAGCAAGGCTTTCCAATACATAAATAGTGTCTGTTTCTTAGATTACAATAGTGTACTGTGCTTATTTGTTCTAAGAGAAGAATTGCTTCTTTATACAGCTCCGACAGAAGCAGGAGTCCGAGTTAAACCTTCAG
TTGTATAGACAATAAACTATAATTTTCATATGCAA

>CORO1C_PACRG_ENST00000549384_ENST00000366889_109125204_163735858 length=666nt
Breakpoint=0nt
TGAACTCCGGAGACGGCATTGACTACAGCCAGCAGAAGAGGGAGAACATTGGGGACTTGATCCAGGAGACACTGGAGGCCTTCGAGCGCTACGGAGGAGAAAATGCCTTTATCAACATTAAGTACGTGGTCCCAACCTACGAGTCTTGCT
TGCTAAACTAACAGTGGCAGCAGCTGGGACTTGAAACCTCCCGTTGGTGTTGGGATCATCTGTCTCTGTTGCTTTTAGCATCTCATTCCTTGTGACTTCCACAGCTTTCTTTTCTACAGCTGCTAAAATAGTGGCTTATGGGCCATTGGA
CTGTTAGCCCTATTGAGAGCAAGGCTTTCCAATACATAAATAGTGTCTGTTTCTTAGATTACAATAGTGTACTGTGCTTATTTGTTCTAAGAGAAGAATTGCTTCTTTATACAGCTCCGACAGAAGCAGGAGTCCGAGTTAAACCTTCAG
TTGTATAGACAATAAACTATAATTTTCATATGCAATTCAGCAATTGCTGTTCTGTGTGTGCCTGCCCTGGGGGTGATGTCAGAGGTTGTAAGGGAAGAGTTTATGCTGACTGCTTACTAGGTGTTTGTCATGGAAGAGAAGCATGGGTTC
AGCAGTGCCTCTCTAGCAGCTGTGCGGAATAATGTGCTTTGACATTCAATAAAACTGTTGAATCTA


check button C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for CORO1C_PACRG

check button In-frame Fusion Protein Sequences.

check button N-Truncated Protein (5UTR-3CDS) Sequences

check button C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for CORO1C_PACRG


check button TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences
NumGene GroupDomain LociFusion Protein IDFusion Gene NamePartnerMutated Residue in WT ProteinSeq. LengthMutated Residue in Fusion Protein

check button CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

NumGene GroupDomain LociFusion Protein IDFusion Gene NamePartnerMutated Residue in WT ProteinSeq. LengthMutated Residue in Fusion Protein

check button TCGA All Mutated Fusion Protein Sequences


Fusion Protein IDSample IDMutated PartnerAAchange in WTSeq. LengthAAchange in Fusion

check button CCLE All Mutated Fusion Protein Sequences


Fusion Protein IDSample IDMutated PartnerAAchange in WTSeq. LengthAAchange in Fusion

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Fusion Gene Exprssed Samples for CORO1C_PACRG


check buttonRNA-seq based fusion gene expressed samples.
SourceStudyDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDBLIHCTCGA-XR-A8TG-01ACORO1C

chr12

109125204-PACRG

chr6

109125204

+
WashULIHCTCGA-XR-A8TG-01ACORO1C

chr12

109125205-PACRG

chr6

163735859

+
cBioPortalLIHC_TCGA_PAN_CAN_ATLAS_2018HCCTCGA-XR-A8TG-01CORO1C

chr12

108731429PACRG

chr6

163314827


check buttonDNA-seq based fusion gene expressed samples.
SourceStudyDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrandSV type


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Related Drugs for CORO1C_PACRG


check button PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.
PMIDFusion Gene NameDrugStudy Title

check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status