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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene Breakpoints

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness

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Fusion Genomic Features

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Fusion Gene ORF Annotations

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Fusion Protein Retained/Non-Retained Functional Features

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Fusion Transcript Sequences

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Fusion Protein Sequences

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Personalized Fusion Protein Sequences

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Fusion Gene Expressed Samples

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Related Drugs

Fusion gene:CLIC4_SRRM1 (FusionGDB2 ID:HG25932TG10250)

Fusion Gene Summary for CLIC4_SRRM1

check button Fusion gene summary
Fusion gene informationFusion gene name: CLIC4_SRRM1
Fusion gene ID: hg25932tg10250
HgeneTgene
Gene symbol

CLIC4

SRRM1

Gene ID

25932

10250

Gene namechloride intracellular channel 4serine and arginine repetitive matrix 1
SynonymsCLIC4L|H1|MTCLIC|huH1|p64H1160-KD|POP101|SRM160
Cytomap

1p36.11

1p36.11

Type of geneprotein-codingprotein-coding
Descriptionchloride intracellular channel protein 4chloride intracellular channel 4 likeepididymis secretory sperm binding proteinintracellular chloride ion channel protein p64H1serine/arginine repetitive matrix protein 1SR-related nuclear matrix protein of 160 kDaSer/Arg-related nuclear matrix protein
Modification date2024040320240407
UniProtAcc

Q9Y696

.
Ensembl transtripts involved in fusion geneENST00000497755, ENST00000374379, 
Fusion gene scores* DoF score* DoF score (Degree of Frequency) = # partners X # break points X # disease types
21 X 7 X 18=2646		* DoF score (Degree of Frequency) = # partners X # break points X # disease types
4 X 24 X 12=1152
# samples 8040
** MAII score** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)
log2(80/2646*10)=-1.72574115650395
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)
log2(40/1152*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLIC4 [Title/Abstract] AND SRRM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCLIC4(25072116)-SRRM1(24972474), # samples:4


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Fusion Gene Breakpoints for CLIC4_SRRM1


check button RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.
HgeneHchrHbpTgeneTchrTbp
CLIC4chr125072116SRRM1chr124972475
CLIC4chr125072116SRRM1chr124997877
CLIC4chr125072116SRRM1chr124962135
CLIC4chr125072116SRRM1chr124959510
CLIC4chr125072116SRRM1chr124958129
CLIC4chr125072116SRRM1chr124995614
CLIC4chr125140710SRRM1chr125140710
CLIC4chr125124342SRRM1chr124972475


check button DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.
HgeneHchrHbpTgeneTchrTbpSV type


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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for CLIC4_SRRM1


check button To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.
* We have 10 tumorigenic mechanism categories of fusion genes as shown below.
Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand FusionsAberrant Chimeric Transcription Factor / Fusion Transcription Factor ActivityEpigenetic Reprogramming / Histone Modifier DysregulationChromatin Remodeling DysregulationCondensate-Driven Transcriptional Rewiring / LLPPromoter / Enhancer HijackingDominant-Negative AntagonismCell Cycle / Checkpoint Bypass / RNA Processing DysregulationSubcellular Mislocalization / Spatial DysregulationNuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.
Fusion Gene NameMechanism CategoryMechanism PubMedTumorigenic ScenariosTumorigenic Scenario PubMedTargeting PointsTargeting PubMedMechanism BackgroundMechanism Background PubMed

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.
Fusion Gene NameMechanism CategoryMechanism PubMedTumorigenic ScenariosTumorigenic Scenario PubMedTargeting PointsTargeting PubMedMechanism BackgroundMechanism Background PubMed

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLIC4

Q9Y696

.

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLIC4

GO:0030336

negative regulation of cell migration

12163372

TgeneSRRM1

GO:0051179

localization

12624182


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Fusion Genomic Features for CLIC4_SRRM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CLIC4chr125072116+SRRM1chr124972474+8.13e-081.00e+00
CLIC4chr125072116+SRRM1chr124995613+9.65e-061.00e+00
CLIC4chr125072116+SRRM1chr124997876+6.21e-049.99e-01


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).
genomic feature

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Fusion Gene ORF Annotations for CLIC4_SRRM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000497755ENST00000323848CLIC4chr1

25072116

+SRRM1chr1

24972474

+
3UTR-3CDSENST00000497755ENST00000323848CLIC4chr1

25072116

+SRRM1chr1

24995613

+
3UTR-3CDSENST00000497755ENST00000323848CLIC4chr1

25072116

+SRRM1chr1

24997876

+
3UTR-3CDSENST00000497755ENST00000374389CLIC4chr1

25072116

+SRRM1chr1

24972474

+
3UTR-3CDSENST00000497755ENST00000374389CLIC4chr1

25072116

+SRRM1chr1

24995613

+
3UTR-3CDSENST00000497755ENST00000374389CLIC4chr1

25072116

+SRRM1chr1

24997876

+
3UTR-3CDSENST00000497755ENST00000447431CLIC4chr1

25072116

+SRRM1chr1

24972474

+
3UTR-3CDSENST00000497755ENST00000447431CLIC4chr1

25072116

+SRRM1chr1

24995613

+
3UTR-3CDSENST00000497755ENST00000447431CLIC4chr1

25072116

+SRRM1chr1

24997876

+
3UTR-3UTRENST00000497755ENST00000479034CLIC4chr1

25072116

+SRRM1chr1

24972474

+
3UTR-3UTRENST00000497755ENST00000479034CLIC4chr1

25072116

+SRRM1chr1

24995613

+
3UTR-3UTRENST00000497755ENST00000479034CLIC4chr1

25072116

+SRRM1chr1

24997876

+
5CDS-3UTRENST00000374379ENST00000479034CLIC4chr1

25072116

+SRRM1chr1

24972474

+
5CDS-3UTRENST00000374379ENST00000479034CLIC4chr1

25072116

+SRRM1chr1

24995613

+
5CDS-3UTRENST00000374379ENST00000479034CLIC4chr1

25072116

+SRRM1chr1

24997876

+
Frame-shiftENST00000374379ENST00000323848CLIC4chr1

25072116

+SRRM1chr1

24995613

+
Frame-shiftENST00000374379ENST00000374389CLIC4chr1

25072116

+SRRM1chr1

24995613

+
Frame-shiftENST00000374379ENST00000447431CLIC4chr1

25072116

+SRRM1chr1

24995613

+
In-frameENST00000374379ENST00000323848CLIC4chr1

25072116

+SRRM1chr1

24972474

+
In-frameENST00000374379ENST00000323848CLIC4chr1

25072116

+SRRM1chr1

24997876

+
In-frameENST00000374379ENST00000374389CLIC4chr1

25072116

+SRRM1chr1

24972474

+
In-frameENST00000374379ENST00000374389CLIC4chr1

25072116

+SRRM1chr1

24997876

+
In-frameENST00000374379ENST00000447431CLIC4chr1

25072116

+SRRM1chr1

24972474

+
In-frameENST00000374379ENST00000447431CLIC4chr1

25072116

+SRRM1chr1

24997876

+

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score
ENST00000374379ENST00000479034CLIC4chr125124342SRRM1chr1249724740.00e+001.33e-02

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Fusion Protein Retained/Non-Retained Functional Features for CLIC4_SRRM1

check buttonProtein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.
fgviewer annotation
- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).
CLIC4_SRRM1_chr1-25072116_chr1-24972474.png
CLIC4_SRRM1_chr1-25072116_chr1-24972474.png
CLIC4_SRRM1_chr1-25072116_chr1-24997876.png
CLIC4_SRRM1_chr1-25072116_chr1-24997876.png

- In-frame and retained protein feature among the 13 regional features (texts).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017139_1707.0905.0Compositional biasBasic and acidic residues
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017171_2077.0905.0Compositional biasBasic residues
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017214_2347.0905.0Compositional biasBasic and acidic residues
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017246_2757.0905.0Compositional biasBasic and acidic residues
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017276_3297.0905.0Compositional biasBasic residues
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017336_3517.0905.0Compositional biasBasic residues
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017352_3687.0905.0Compositional biasLow complexity
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017428_4387.0905.0Compositional biasPolar residues
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017478_5017.0905.0Compositional biasLow complexity
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017503_5187.0905.0Compositional biasBasic and acidic residues
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017533_5607.0905.0Compositional biasBasic residues
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017567_5927.0905.0Compositional biasBasic residues
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017593_6057.0905.0Compositional biasLow complexity
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017621_6367.0905.0Compositional biasBasic residues
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017649_6637.0905.0Compositional biasBasic residues
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017701_7197.0905.0Compositional biasLow complexity
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017736_7597.0905.0Compositional biasLow complexity
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017771_7867.0905.0Compositional biasLow complexity
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017809_8347.0905.0Compositional biasBasic residues
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017837_8667.0905.0Compositional biasLow complexity
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017882_8927.0905.0Compositional biasBasic and acidic residues
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417809_834800.0905.0Compositional biasBasic residues
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417837_866800.0905.0Compositional biasLow complexity
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417882_892800.0905.0Compositional biasBasic and acidic residues
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB301727_1267.0905.0DomainPWI
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017139_9047.0905.0RegionDisordered
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB3017300_6887.0905.0RegionNote=Necessary for speckles and matrix localization

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLIC4chr1:25072116chr1:24972474ENST00000374379Q9Y6961681_24424.0254.0DomainGST C-terminal
HgeneCLIC4chr1:25072116chr1:24997876ENST00000374379Q9Y6961681_24424.0254.0DomainGST C-terminal
HgeneCLIC4chr1:25072116chr1:24972474ENST00000374379Q9Y6961635_3824.0254.0MotifG-site
HgeneCLIC4chr1:25072116chr1:24997876ENST00000374379Q9Y6961635_3824.0254.0MotifG-site
HgeneCLIC4chr1:25072116chr1:24972474ENST00000374379Q9Y696162_10124.0254.0RegionRequired for insertion into the membrane
HgeneCLIC4chr1:25072116chr1:24997876ENST00000374379Q9Y696162_10124.0254.0RegionRequired for insertion into the membrane
HgeneCLIC4chr1:25072116chr1:24972474ENST00000374379Q9Y6961637_5724.0254.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
HgeneCLIC4chr1:25072116chr1:24997876ENST00000374379Q9Y6961637_5724.0254.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417139_170800.0905.0Compositional biasBasic and acidic residues
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417171_207800.0905.0Compositional biasBasic residues
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417214_234800.0905.0Compositional biasBasic and acidic residues
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417246_275800.0905.0Compositional biasBasic and acidic residues
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417276_329800.0905.0Compositional biasBasic residues
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417336_351800.0905.0Compositional biasBasic residues
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417352_368800.0905.0Compositional biasLow complexity
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417428_438800.0905.0Compositional biasPolar residues
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417478_501800.0905.0Compositional biasLow complexity
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417503_518800.0905.0Compositional biasBasic and acidic residues
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417533_560800.0905.0Compositional biasBasic residues
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417567_592800.0905.0Compositional biasBasic residues
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417593_605800.0905.0Compositional biasLow complexity
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417621_636800.0905.0Compositional biasBasic residues
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417649_663800.0905.0Compositional biasBasic residues
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417701_719800.0905.0Compositional biasLow complexity
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417736_759800.0905.0Compositional biasLow complexity
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417771_786800.0905.0Compositional biasLow complexity
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB3141727_126800.0905.0DomainPWI
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB30171_1517.0905.0RegionNote=Necessary for DNA and RNA-binding
TgeneSRRM1chr1:25072116chr1:24972474ENST00000323848Q8IYB30171_1567.0905.0RegionNote=Necessary for mRNA 3'-end cleavage and cytoplasmic accumulation
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417139_904800.0905.0RegionDisordered
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB314171_151800.0905.0RegionNote=Necessary for DNA and RNA-binding
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB314171_156800.0905.0RegionNote=Necessary for mRNA 3'-end cleavage and cytoplasmic accumulation
TgeneSRRM1chr1:25072116chr1:24997876ENST00000323848Q8IYB31417300_688800.0905.0RegionNote=Necessary for speckles and matrix localization


check button - Retained PPIs in in-frame fusion.
PartnerHgeneHbpTgeneTbpENSTUniProtStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerHgeneHbpTgeneTbpENSTUniProtStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Fusion Transcript Sequence for CLIC4_SRRM1

check button In-frame Fusion Transcript Sequences.

check button N-Truncated Transcript (5UTR-3CDS) Sequences

check button C-Truncated Transcript (5CDS-3UTR) Sequences
>CLIC4_SRRM1_ENST00000374379_ENST00000479034_25124342_24972474 length=379nt
Breakpoint=379nt
AAGCGGCTCGGGCTGCGGCTGGCTCAGAGTGGCGCGGGGGGCGTGGGGCGGTGCTGAGGAGCTGAAGCCGTGGCCAGCTCGACGCCGGACAGTCCAGCGAGCAGCACGGCGGGAACCGGCAGCCGGAGCAGTCCCGGAGCAGAAGCAGCA
GCAGCAGCAGCAGCCCTCGCCGTTCGCGGAGCGCAGCCGAGCCGGCCATGGCGTTGTCGATGCCGCTGAATGGGCTGAAGGAGGAGGACAAAGAGCCCCTCATCGAGCTCTTCGTCAAGGCTGGCAGTGATGGTGAAAGCATAGGAAACT
GCCCCTTTTCCCAGAGGCTCTTCATGATTCTTTGGCTCAAAGGAGTTGTATTTAGTGTGACGACTGTTGACCTGAAAAG


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Fusion Protein Sequence for CLIC4_SRRM1

check button In-frame Fusion Protein Sequences.

check button N-Truncated Protein (5UTR-3CDS) Sequences

check button C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for CLIC4_SRRM1


check button TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences
NumGene GroupDomain LociFusion Protein IDFusion Gene NamePartnerMutated Residue in WT ProteinSeq. LengthMutated Residue in Fusion Protein

check button CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

NumGene GroupDomain LociFusion Protein IDFusion Gene NamePartnerMutated Residue in WT ProteinSeq. LengthMutated Residue in Fusion Protein

check button TCGA All Mutated Fusion Protein Sequences


Fusion Protein IDSample IDMutated PartnerAAchange in WTSeq. LengthAAchange in Fusion

check button CCLE All Mutated Fusion Protein Sequences


Fusion Protein IDSample IDMutated PartnerAAchange in WTSeq. LengthAAchange in Fusion

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Fusion Gene Exprssed Samples for CLIC4_SRRM1


check buttonRNA-seq based fusion gene expressed samples.
SourceStudyDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
CCLESerous Ovarian CancerTO14CLIC4

chr1

25072116+SRRM1

chr1

24972475

+
CCLELung AdenocarcinomaA427CLIC4

chr1

25072116+SRRM1

chr1

24972475

+
CCLEAlveolar RhabdomyosarcomaRH4CLIC4

chr1

25072116+SRRM1

chr1

24997877

+
CCLELung AdenocarcinomaA427CLIC4

chr1

25072116+SRRM1

chr1

24962135

+
CCLELung AdenocarcinomaA427CLIC4

chr1

25072116+SRRM1

chr1

24959510

+
CCLELung AdenocarcinomaA427CLIC4

chr1

25072116+SRRM1

chr1

24958129

+
CCLEHigh-Grade Serous Ovarian CancerONCODG1CLIC4

chr1

25072116+SRRM1

chr1

24995614

+
ChimerDBGBMTCGA-06-2565-01ACLIC4

chr1

25140710+SRRM1

chr1

25140710

+
ChimerDBGBMTCGA-06-2565CLIC4

chr1

25140710+SRRM1

chr1

25140710

+
cBioPortalCCLE_BROAD_2019MIXEDA427_LUNGCLIC4

chr1

25072116SRRM1

chr1

24959510

cBioPortalCCLE_BROAD_2019MIXEDA427_LUNGCLIC4

chr1

25072116SRRM1

chr1

24962135

cBioPortalCCLE_BROAD_2019MIXEDA427_LUNGCLIC4

chr1

25072116SRRM1

chr1

24972475

cBioPortalCCLE_BROAD_2019MIXEDEN_ENDOMETRIUMCLIC4

chr1

25124342SRRM1

chr1

24972475

cBioPortalCCLE_BROAD_2019MIXEDONCODG1_OVARYCLIC4

chr1

25072116SRRM1

chr1

24995614

cBioPortalCCLE_GENENTECH_2014MIXEDS-A-427CLIC4

chr1

25072116SRRM1

chr1

24972475


check buttonDNA-seq based fusion gene expressed samples.
SourceStudyDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrandSV type


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Related Drugs for CLIC4_SRRM1


check button PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.
PMIDFusion Gene NameDrugStudy Title

check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status