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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:INTS6_DCBLD2 (FusionGDB2 ID:HG26512TG131566)

Fusion Gene Summary for INTS6_DCBLD2

Fusion gene summary

Fusion gene information	Fusion gene name: INTS6_DCBLD2
	Fusion gene ID: hg26512tg131566
		Hgene	Tgene
	Gene symbol	INTS6	DCBLD2
	Gene ID	26512	131566
	Gene name	integrator complex subunit 6	discoidin, CUB and LCCL domain containing 2
	Synonyms	DBI-1\|DDX26\|DDX26A\|DICE1\|HDB\|INT6\|Notchl2	CLCP1\|ESDN
	Cytomap	13q14.3	3q12.1\|3
	Type of gene	protein-coding	protein-coding
	Description	integrator complex subunit 6DEAD box proteinDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26RNA helicase HDBprotein deleted in cancer 1	discoidin, CUB and LCCL domain-containing protein 21700055P21RikCUB, LCCL and coagulation factor V/VIII-homology domains protein 1coagulation factor V/VIII-homology domains protein 1endothelial and smooth muscle cell-derived neuropilin-like protein
	Modification date	20240403	20240411
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000311234, ENST00000398119, ENST00000420668, ENST00000463928, ENST00000425000, ENST00000491723, ENST00000442263, ENST00000490542, ENST00000497989,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 4 X 3 X 4=48	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 4 X 7 X 7=196
	# samples	8	11
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(8/4810)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(11/19610)=-0.833350130590549 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: INTS6 [Title/Abstract] AND DCBLD2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	INTS6(52025160)-DCBLD2(98600611), # samples:2

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Fusion Gene Breakpoints for INTS6_DCBLD2

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
INTS6	chr13	52025160	DCBLD2	chr3	98600611
INTS6	chr13	52025161	DCBLD2	chr3	98600611

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for INTS6_DCBLD2

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
INTS6-DCBLD2	Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions M1		Promoter swap alters INTS6 expression while DCBLD2 transmembrane protein hyper-activates EGFR/VEGFR signaling and invasion.		RTK inhibitors; FAK/Src inhibitors		Invasive solid tumors and glioblastoma

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
INTS6-DCBLD2	Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions M1		Promoter swap alters INTS6 expression while DCBLD2 transmembrane protein hyper-activates EGFR/VEGFR signaling and invasion.	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 34095137; Title: DCBLD2 Affects the Development of Colorectal Cancer via EMT and Angiogenesis and Modulates 5-FU Drug Resistance.	RTK inhibitors; FAK/Src inhibitors		Invasive solid tumors and glioblastoma	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 34095137; Title: DCBLD2 Affects the Development of Colorectal Cancer via EMT and Angiogenesis and Modulates 5-FU Drug Resistance.; PMID: 33834039; Title: Transcriptomic Profiling Identifies DCBLD2 as a Diagnostic and Prognostic Biomarker in Pancreatic Ductal Adenocarcinoma.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	INTS6	GO:0016180	snRNA processing	16239144
Tgene	DCBLD2	GO:0030308	negative regulation of cell growth	11447234
Tgene	DCBLD2	GO:0042060	wound healing	11447234

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Fusion Genomic Features for INTS6_DCBLD2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
INTS6	chr13	52025160	-	DCBLD2	chr3	98600611	-	3.87e-02	9.61e-01

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
INTS6	chr13	52025160	-	DCBLD2	chr3	98600611	-	3.87e-02	9.61e-01

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for INTS6_DCBLD2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000425000	ENST00000326840	INTS6	chr13	52025160	-	DCBLD2	chr3	98600611	-
5UTR-3CDS	ENST00000425000	ENST00000326857	INTS6	chr13	52025160	-	DCBLD2	chr3	98600611	-
5UTR-3CDS	ENST00000491723	ENST00000326840	INTS6	chr13	52025160	-	DCBLD2	chr3	98600611	-
5UTR-3CDS	ENST00000491723	ENST00000326857	INTS6	chr13	52025160	-	DCBLD2	chr3	98600611	-
Frame-shift	ENST00000311234	ENST00000326840	INTS6	chr13	52025160	-	DCBLD2	chr3	98600611	-
Frame-shift	ENST00000311234	ENST00000326857	INTS6	chr13	52025160	-	DCBLD2	chr3	98600611	-
Frame-shift	ENST00000398119	ENST00000326840	INTS6	chr13	52025160	-	DCBLD2	chr3	98600611	-
Frame-shift	ENST00000398119	ENST00000326857	INTS6	chr13	52025160	-	DCBLD2	chr3	98600611	-
Frame-shift	ENST00000420668	ENST00000326840	INTS6	chr13	52025160	-	DCBLD2	chr3	98600611	-
Frame-shift	ENST00000420668	ENST00000326857	INTS6	chr13	52025160	-	DCBLD2	chr3	98600611	-
Frame-shift	ENST00000463928	ENST00000326840	INTS6	chr13	52025160	-	DCBLD2	chr3	98600611	-
Frame-shift	ENST00000463928	ENST00000326857	INTS6	chr13	52025160	-	DCBLD2	chr3	98600611	-

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000425000	ENST00000326840	INTS6	chr13	52025160	DCBLD2	chr3	98600611	0	368
ENST00000425000	ENST00000326857	INTS6	chr13	52025160	DCBLD2	chr3	98600611	0	669
ENST00000491723	ENST00000326840	INTS6	chr13	52025160	DCBLD2	chr3	98600611	0	368
ENST00000491723	ENST00000326857	INTS6	chr13	52025160	DCBLD2	chr3	98600611	0	669

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000425000	ENST00000326840	INTS6	chr13	52025160	DCBLD2	chr3	98600611	0.00e+00	2.15e-04
ENST00000425000	ENST00000326857	INTS6	chr13	52025160	DCBLD2	chr3	98600611	0.00e+00	2.21e-04
ENST00000491723	ENST00000326840	INTS6	chr13	52025160	DCBLD2	chr3	98600611	0.00e+00	2.15e-04
ENST00000491723	ENST00000326857	INTS6	chr13	52025160	DCBLD2	chr3	98600611	0.00e+00	2.21e-04

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for INTS6_DCBLD2

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for INTS6_DCBLD2

In-frame Fusion Transcript Sequences.

N-Truncated Transcript (5UTR-3CDS) Sequences

>INTS6_DCBLD2_ENST00000425000_ENST00000326840_52025160_98600611 length=5554nt 
 Breakpoint=0nt
GTGATGGATGTGGACACACTGTACTAGGCCCTGAGAGTGGAACCCTTACATCCATAAACTACCCACAGACCTATCCCAACAGCACTGTTTGTGAATGGGAGATCCGTGTAAAGATGGGAGAGAGAGTTCGCATCAAATTTGGTGACTTTG
ACATTGAAGATTCTGATTCTTGTCACTTTAATTACTTGAGAATTTATAATGGAATTGGAGTCAGCAGAACTGAAATAGGCAAATACTGTGGTCTGGGGTTGCAAATGAACCATTCAATTGAATCAAAAGGCAATGAAATCACATTGCTGT
TCATGAGTGGAATCCATGTTTCTGGACGCGGATTTTTGGCCTCATACTCTGTTATAGATAAACAAGATCTAATTACTTGTTTGGACACTGCATCCAATTTTTTGGAACCTGAGTTCAGTAAGTACTGCCCAGCTGGTTGTCTGCTTCCTT
TTGCTGAGATATCTGGAACAATTCCTCATGGATATAGAGATTCCTCGCCATTGTGCATGGCTGGTGTGCATGCAGGAGTAGTGTCAAACACGTTGGGCGGCCAAATCAGTGTTGTAATTAGTAAAGGTATCCCCTATTATGAAAGTTCTT
TGGCTAACAACGTCACATCTGTGGTGGGACACTTATCTACAAGTCTTTTTACATTTAAGACAAGTGGATGTTATGGAACACTGGGGATGGAGTCTGGTGTGATCGCGGATCCTCAAATAACAGCATCATCTGTGCTGGAGTGGACTGACC
ACACAGGGCAAGAGAACAGTTGGAAACCCAAAAAAGCCAGGCTGAAAAAACCTGGACCGCCTTGGGCTGCTTTTGCCACTGATGAATACCAGTGGTTACAAATAGATTTGAATAAGGAAAAGAAAATAACAGGCATTATAACCACTGGAT
CCACCATGGTGGAGCACAATTACTATGTGTCTGCCTACAGAATCCTGTACAGTGATGATGGGCAGAAATGGACTGTGTACAGAGAGCCTGGTGTGGAGCAAGATAAGATATTTCAAGGAAACAAAGATTATCACCAGGATGTGCGTAATA
ACTTTTTGCCACCAATTATTGCACGTTTTATTAGAGTGAATCCTACCCAATGGCAGCAGAAAATTGCCATGAAAATGGAGCTGCTCGGATGTCAGTTTATTCCTAAAGGTCGTCCTCCAAAACTTACTCAACCTCCACCTCCTCGGAACA
GCAATGACCTCAAAAACACTACAGCCCCTCCAAAAATAGCCAAAGGTCGTGCCCCAAAATTTACGCAACCACTACAACCTCGCAGTAGCAATGAATTTCCTGCACAGACAGAACAAACAACTGCCAGTCCTGATATCAGAAATACTACCG
TAACTCCAAATGTAACCAAAGATGTAGCGCTGGCTGCAGTTCTTGTCCCTGTGCTGGTCATGGTCCTCACTACTCTCATTCTCATATTAGTGTGTGCTTGGCACTGGAGAAACAGAAAGAAAAAAACTGAAGGCACCTATGACTTACCTT
ACTGGGACCGGGCAGGTTGGTGGAAAGGAATGAAGCAGTTTCTTCCTGCAAAAGCAGTGGACCATGAGGAAACCCCAGTTCGCTATAGCAGCAGCGAAGTTAATCACCTGAGTCCAAGAGAAGTCACCACAGTGCTGCAGGCTGACTCTG
CAGAGTATGCTCAGCCACTGGTAGGAGGAATTGTTGGTACACTTCATCAAAGATCTACCTTTAAACCAGAAGAAGGAAAAGAAGCAGGCTATGCAGACCTAGATCCTTACAACTCACCAGGGCAGGAAGTTTATCATGCCTATGCTGAAC
CACTCCCAATTACGGGGCCTGAGTATGCAACCCCAATCATCATGGACATGTCAGGGCACCCCACAACTTCAGTTGGTCAGCCCTCCACATCCACTTTCAAGGCTACGGGGAACCAACCTCCCCCACTAGTGGGAACTTACAATACACTTC
TCTCCAGGACTGACAGCTGCTCCTCAGCCCAGGCCCAGTATGATACCCCGAAAGCTGGGAAGCCAGGTCTACCTGCCCCAGACGAATTGGTGTACCAGGTGCCACAGAGCACACAAGAAGTATCAGGAGCAGGAAGGGATGGGGAATGTG
ATGTTTTTAAAGAAATCCTTTGAAGATGATGCTGCTTTTTACAAAGCATCGTTTTAAAGCACATGGCCTTTTTTTTTTAATTATTAGTGGTAGTAATATATAGAATGTATTACATAACTGTCACTGAAGTGGTTGGGGAAAATGTGGTGA
CTGAGGTACAGGAAACTACTAATCTTGCCATCTTGCTTTAAGGTGTTATGGTGGCACAGTTACTGCTCGCCTGTTAAATTTCAAATGTCCTGTTTGATACTACTGTAGAACACTATTTTTAATACAGAAAAAGCTCCCTATAATGCACTT
CAGAGAAATTAAAAATCACAGAGTATTTATTACCAATGCTGCAGGTACATTAATGAACTCGAGATGGCTCTGTAAGCCTGACTGGCAATAACGCACGGTACTGTTCTTGAAATACCTAATGGCTTGAAATTCTAGTCTGTTTGTGAAAGA
TGGGTACTATCATGATTTCCTCTTCTATTCCTATATTCTTTTCTGGATTTTTTTTAATAATTAGTGATATAAGCATTGTTTTTATTGCAGCCATATCCACTTATCCATCTTAAGATCTGTAGCTGGGATTTTCTGACTTGTAATGAGCAG
GGGGATTGCTTTTTCACTTTGTGACACTCTTTAGAGCTTTAATGCTTCACAGTATATGGCCTGGTCTCATCCTTGCGTGTTCCACTTGAGGCCCTTTGGTGTCTTGCCCCATTCTTGTGTTTATAAAATGTTTGAGTATTTCTGATGAGT
GATGCTTGCCTTAGTCTCATGAATTCAGATCCCTTCATGTCCTTTAAGTATGCTCCTCAATGTGTAAACAGGAACAACTTTATGATTTGAAAGCTTTAAAGGAGATTCTTCTCCCACCCCCAACTTTATTTGCAATGGGATTTTTCCTAG
GAGAGTTATGAAAAGTTGAAGGCTTCTAAGGGAATACTGTAAACATGACCCACTTATATTTATCACAGTGAAAGGCAAAATTATTCACTCAGAAGTAATATAAATTACCTCTTTAAAAAGTAACCAGAATTTGTCCTTTTTGGTTTTATA
CATTCACAAACATATACATTTTTCTTGAGTCTCAAGGTATTTTATATTTTTAGTCAGAAAAAATAATTTTTCATTTCAGTTTTCCATAAACTGTTACACAAAATATAAACCTAACGTGTATTTTTCAGGACTGCGTGATCGTGCACTTTG
TGTGGTAAGAGGTTTGAGTAGTCCTATATGTCACCTAGGGAACAGACATTATAGCTTACTAGCAAATGAATATTCATGCCTTGTTTTTGATACCTCCTGGCAGCTTCCATGTCACCACTTGTTCATACCTGCCCAGAGCTAGTTTTAGAC
ATGGCAAAATAGAAATCATCTGTAATTTATTAGCTAACAATGTAAAACCATCTTTTAAAGCCTTCAGACTGTCAAGACGACATGAGCAGCTCACCATATGATAAAAATACATAAATTTGACATTCCCTCTTCCATAAACCTTTGTTTGTA
GATTTAATGTTGAACAGTACTTTTCCATAAAGTTCTAGTCACTTCTGTTGGCCTGAGCCACCAGATTATGATGTTGCCAGAATTCACTCAATTTGAATAAAGATGAACAGTATTTGTTTTCTTGTTTCCATGAATTATATCAGTATTCTA
AAACATCGCTTCAGAAAGAGAACTGTTTATTTCTGCAGGCTTCCTGTCCTTTTGTGGTATGGTTTTTTGGCCTTATTTTCACTGGCTTTTCCTTCTCCAAACTTTGAGGCGTGATTTCATTCATTGAAGAATCAATACATATTTTGTTTC
AAAATGTTTGAAACAAAAGACATAGATGGTAGACTTTTATTAAAACATATATGGATGTGGAAAGCACATATATTAATGCAGTCATCCCTTTTCAGGTGGGAAGAGAGCAAACCAGTTGATTTTTTAATTCATCCTTAGTACACAGAGAAT
ATACTTTTCCTCAAGTAATATACCTGTTTGAAGCTTTAAGAGAGATGTTTTTGGTAACTATTTCATTTTCCCAAAGAAGTTTGCTATTCTTGTGTTAATTGTGTATACCTGATTGTTTTTTCCTGGAGGTTTTTGTTGTTGTTGTTTAGT
TTTGGGTTTTTTTTTTTTTAAGAGGGGCAAGTGTTTTCTGAAATGATGCATATTTTAAGACTCGATTCATATTGCCACTGTGCTATCCTTGAACTACCAATAATTTTTATAAAATATCTAGTTTTTACTACTTTTATATAAACTTTACTT
TCCAGATGAAGAGCTGAGCCTGATTCAAATGGTTTTTCTGCTTTATACTTCTTTTTAGTTCATTGGTTTTTATAGTAGAGGTTTTCTATTTTTTTTTTTTTTTTTTTTACTACATTTATATGTCTGATACATATACGGCTTTGGAGACAA
TCAAGTAACAACTGAAAATGTGAAAGTAACCATATCTGACAAAATTCCCTTGAATTTTTATCCTTTGCTTGCAACATTTAAGACTCAAAGTCACTGGTATATTGGATTAAGTTTTTTCCTGTTAATGCAATTATAGAAATACATCGGAGA
CACAACAAATGTGGCCATTACAGGTTTCATAAAATTACACTGACTTGGCTGTTACTTGATCTTAGGAAACAGCACAGTTTAAGATATTGTGAATTCTGACTTATACTTTATTAAATGCTGTAAATCTAAATAGATCCTGTTGGATGTGAT
GGGTCTAGTCCAGTTTATTTAAGTTCATGTTTCACTGTTTGCACTTTGCATTGAACAATGGGTTTATTCGCTGATGTAAACGGTTCGAGTGAAGAATTAATGCAGTAAGTATGACAACACATACACACTTGCCTCTCCCCATCTCCAGAA
GAGGGGAGCAGAGTCCGAGCTTATCTAAATATGAATGTGGCCACAAAGCTGTGGAAGGTGACAAAGCTTAAACACCTTTGCCCTGGCTCTGCATTGTCACCTAGAGAGCAAGAGGTCTATAGAAACATCATGTCACATGAAACGATTCTC
TGCTTTTTGGTTCTGAACTTGAAGTCCCTAAACTGCAAAATCTAAGAGTTGGGTGGTTATTAAAATGCTTTTAAAGTCAACTGTGGCACCAATTCTAATGTAATCCAACTTGTGACTGTTTTTTTTTGTTTTGTTTTGTTTTTGTGTGTG
TGTGTGTGGCACTGGGAAAAGTGGAAACAAACATGTATTGAAATACATATTGGAAATAAAAATGGTTTGAGCGTCAGTGATATTCTCCCAGAATGTACTTATCTTACCTCGGCATGTACTGTAGTCACTCAGTATTTGTATATGTTGCTA
GAATTTAGATTGTAAAATAGTGAAATTTTAATGTGTTCATTTGTTTTTAATGTATATATGTCTTGCTCAGATTATTTGGTTTAAATAAAACAACCTTGAGGTTTGTAGCTTTTCCTTATACTATAAAATGCCAGATTCTTCTATTTTAAC
CTCA

>INTS6_DCBLD2_ENST00000425000_ENST00000326857_52025160_98600611 length=3754nt 
 Breakpoint=0nt
GTGATGGATGTGGACACACTGTACTAGGCCCTGAGAGTGGAACCCTTACATCCATAAACTACCCACAGACCTATCCCAACAGCACTGTTTGTGAATGGGAGATCCGTGTAAAGATGGGAGAGAGAGTTCGCATCAAATTTGGTGACTTTG
ACATTGAAGATTCTGATTCTTGTCACTTTAATTACTTGAGAATTTATAATGGAATTGGAGTCAGCAGAACTGAAATAGGCAAATACTGTGGTCTGGGGTTGCAAATGAACCATTCAATTGAATCAAAAGGCAATGAAATCACATTGCTGT
TCATGAGTGGAATCCATGTTTCTGGACGCGGATTTTTGGCCTCATACTCTGTTATAGATAAACAAGATCTAATTACTTGTTTGGACACTGCATCCAATTTTTTGGAACCTGAGTTCAGTAAGTACTGCCCAGCTGGTTGTCTGCTTCCTT
TTGCTGAGATATCTGGAACAATTCCTCATGGATATAGAGATTCCTCGCCATTGTGCATGGCTGGTGTGCATGCAGGAGTAGTGTCAAACACGTTGGGCGGCCAAATCAGTGTTGTAATTAGTAAAGGTATCCCCTATTATGAAAGTTCTT
TGGCTAACAACGTCACATCTGTGGTGGGACACTTATCTACAAGTCTTTTTACATTTAAGACAAGTGGATGTTATGGAACACTGGGGATGGAGTCTGGTGTGATCGCGGATCCTCAAATAACAGCATCATCTGTGCTGGAGTGGACTGACC
ACACAGGGCAAGAGAACAGTTGGAAACCCAAAAAAGCCAGGCTGAAAAAACCTGGACCGCCTTGGGCTGCTTTTGCCACTGATGAATACCAGTGGTTACAAATAGATTTGAATAAGGAAAAGAAAATAACAGGCATTATAACCACTGGAT
CCACCATGGTGGAGCACAATTACTATGTGTCTGCCTACAGAATCCTGTACAGTGATGATGGGCAGAAATGGACTGTGTACAGAGAGCCTGGTGTGGAGCAAGATAAGATATTTCAAGGAAACAAAGATTATCACCAGGATGTGCGTAATA
ACTTTTTGCCACCAATTATTGCACGTTTTATTAGAGTGAATCCTACCCAATGGCAGCAGAAAATTGCCATGAAAATGGAGCTGCTCGGATGTCAGTTTATTCCTAAAGGTCGTCCTCCAAAACTTACTCAACCTCCACCTCCTCGGAACA
GCAATGACCTCAAAAACACTACAGCCCCTCCAAAAATAGCCAAAGGTCGTGCCCCAAAATTTACGCAACCACTACAACCTCGCAGTAGCAATGAATTTCCTGCACAGACAGAACAAACAACTGCCAGTCCTGATATCAGAAATACTACCG
TAACTCCAAATGTAACCAAAGATGTAGCGCTGGCTGCAGTTCTTGTCCCTGTGCTGGTCATGGTCCTCACTACTCTCATTCTCATATTAGTGTGTGCTTGGCACTGGAGAAACAGAAAGAAAAAAACTGAAGGCACCTATGACTTACCTT
ACTGGGACCGGGCAGGTTTTTATTTAATGGTCTCTTTGGCTTGCCGTCACAATGAAGGTTGGTGGAAAGGAATGAAGCAGTTTCTTCCTGCAAAAGCAGTGGACCATGAGGAAACCCCAGTTCGCTATAGCAGCAGCGAAGTTAATCACC
TGAGTCCAAGAGAAGTCACCACAGTGCTGCAGGCTGACTCTGCAGAGTATGCTCAGCCACTGGTAGGAGGAATTGTTGGTACACTTCATCAAAGATCTACCTTTAAACCAGAAGAAGGAAAAGAAGCAGGCTATGCAGACCTAGATCCTT
ACAACTCACCAGGGCAGGAAGTTTATCATGCCTATGCTGAACCACTCCCAATTACGGGGCCTGAGTATGCAACCCCAATCATCATGGACATGTCAGGGCACCCCACAACTTCAGTTGGTCAGCCCTCCACATCCACTTTCAAGGCTACGG
GGAACCAACCTCCCCCACTAGTGGGAACTTACAATACACTTCTCTCCAGGACTGACAGCTGCTCCTCAGCCCAGGCCCAGTATGATACCCCGAAAGCTGGGAAGCCAGGTCTACCTGCCCCAGACGAATTGGTGTACCAGGTGCCACAGA
GCACACAAGAAGTATCAGGAGCAGGAAGGGATGGGGAATGTGATGTTTTTAAAGAAATCCTTTGAAGATGATGCTGCTTTTTACAAAGCATCGTTTTAAAGCACATGGCCTTTTTTTTTTAATTATTAGTGGTAGTAATATATAGAATGT
ATTACATAACTGTCACTGAAGTGGTTGGGGAAAATGTGGTGACTGAGGTACAGGAAACTACTAATCTTGCCATCTTGCTTTAAGGTGTTATGGTGGCACAGTTACTGCTCGCCTGTTAAATTTCAAATGTCCTGTTTGATACTACTGTAG
AACACTATTTTTAATACAGAAAAAGCTCCCTATAATGCACTTCAGAGAAATTAAAAATCACAGAGTATTTATTACCAATGCTGCAGGTACATTAATGAACTCGAGATGGCTCTGTAAGCCTGACTGGCAATAACGCACGGTACTGTTCTT
GAAATACCTAATGGCTTGAAATTCTAGTCTGTTTGTGAAAGATGGGTACTATCATGATTTCCTCTTCTATTCCTATATTCTTTTCTGGATTTTTTTTAATAATTAGTGATATAAGCATTGTTTTTATTGCAGCCATATCCACTTATCCAT
CTTAAGATCTGTAGCTGGGATTTTCTGACTTGTAATGAGCAGGGGGATTGCTTTTTCACTTTGTGACACTCTTTAGAGCTTTAATGCTTCACAGTATATGGCCTGGTCTCATCCTTGCGTGTTCCACTTGAGGCCCTTTGGTGTCTTGCC
CCATTCTTGTGTTTATAAAATGTTTGAGTATTTCTGATGAGTGATGCTTGCCTTAGTCTCATGAATTCAGATCCCTTCATGTCCTTTAAGTATGCTCCTCAATGTGTAAACAGGAACAACTTTATGATTTGAAAGCTTTAAAGGAGATTC
TTCTCCCACCCCCAACTTTATTTGCAATGGGATTTTTCCTAGGAGAGTTATGAAAAGTTGAAGGCTTCTAAGGGAATACTGTAAACATGACCCACTTATATTTATCACAGTGAAAGGCAAAATTATTCACTCAGAAGTAATATAAATTAC
CTCTTTAAAAAGTAACCAGAATTTGTCCTTTTTGGTTTTATACATTCACAAACATATACATTTTTCTTGAGTCTCAAGGTATTTTATATTTTTAGTCAGAAAAAATAATTTTTCATTTCAGTTTTCCATAAACTGTTACACAAAATATAA
ACCTAACGTGTATTTTTCAGGACTGCGTGATCGTGCACTTTGTGTGGTAAGAGGTTTGAGTAGTCCTATATGTCACCTAGGGAACAGACATTATAGCTTACTAGCAAATGAATATTCATGCCTTGTTTTTGATACCTCCTGGCAGCTTCC
ATGTCACCACTTGTTCATACCTGCCCAGAGCTAGTTTTAGACATGGCAAAATAGAAATCATCTGTAATTTATTAGCTAACAATGTAAAACCATCTTTTAAAGCCTTCAGACTGTCAAGACGACATGAGCAGCTCACCATATGATAAAAAT
ACATAAATTTGACATTCCCTCTTCCATAAACCTTTGTTTGTAGATTTAATGTTGAACAGTACTTTTCCATAAAGTTCTAGTCACTTCTGTTGGCCTGAGCCACCAGATTATGATGTTGCCAGAATTCACTCAATTTGAATAAAGATGAAC
AGTA

>INTS6_DCBLD2_ENST00000491723_ENST00000326840_52025160_98600611 length=5554nt 
 Breakpoint=0nt
GTGATGGATGTGGACACACTGTACTAGGCCCTGAGAGTGGAACCCTTACATCCATAAACTACCCACAGACCTATCCCAACAGCACTGTTTGTGAATGGGAGATCCGTGTAAAGATGGGAGAGAGAGTTCGCATCAAATTTGGTGACTTTG
ACATTGAAGATTCTGATTCTTGTCACTTTAATTACTTGAGAATTTATAATGGAATTGGAGTCAGCAGAACTGAAATAGGCAAATACTGTGGTCTGGGGTTGCAAATGAACCATTCAATTGAATCAAAAGGCAATGAAATCACATTGCTGT
TCATGAGTGGAATCCATGTTTCTGGACGCGGATTTTTGGCCTCATACTCTGTTATAGATAAACAAGATCTAATTACTTGTTTGGACACTGCATCCAATTTTTTGGAACCTGAGTTCAGTAAGTACTGCCCAGCTGGTTGTCTGCTTCCTT
TTGCTGAGATATCTGGAACAATTCCTCATGGATATAGAGATTCCTCGCCATTGTGCATGGCTGGTGTGCATGCAGGAGTAGTGTCAAACACGTTGGGCGGCCAAATCAGTGTTGTAATTAGTAAAGGTATCCCCTATTATGAAAGTTCTT
TGGCTAACAACGTCACATCTGTGGTGGGACACTTATCTACAAGTCTTTTTACATTTAAGACAAGTGGATGTTATGGAACACTGGGGATGGAGTCTGGTGTGATCGCGGATCCTCAAATAACAGCATCATCTGTGCTGGAGTGGACTGACC
ACACAGGGCAAGAGAACAGTTGGAAACCCAAAAAAGCCAGGCTGAAAAAACCTGGACCGCCTTGGGCTGCTTTTGCCACTGATGAATACCAGTGGTTACAAATAGATTTGAATAAGGAAAAGAAAATAACAGGCATTATAACCACTGGAT
CCACCATGGTGGAGCACAATTACTATGTGTCTGCCTACAGAATCCTGTACAGTGATGATGGGCAGAAATGGACTGTGTACAGAGAGCCTGGTGTGGAGCAAGATAAGATATTTCAAGGAAACAAAGATTATCACCAGGATGTGCGTAATA
ACTTTTTGCCACCAATTATTGCACGTTTTATTAGAGTGAATCCTACCCAATGGCAGCAGAAAATTGCCATGAAAATGGAGCTGCTCGGATGTCAGTTTATTCCTAAAGGTCGTCCTCCAAAACTTACTCAACCTCCACCTCCTCGGAACA
GCAATGACCTCAAAAACACTACAGCCCCTCCAAAAATAGCCAAAGGTCGTGCCCCAAAATTTACGCAACCACTACAACCTCGCAGTAGCAATGAATTTCCTGCACAGACAGAACAAACAACTGCCAGTCCTGATATCAGAAATACTACCG
TAACTCCAAATGTAACCAAAGATGTAGCGCTGGCTGCAGTTCTTGTCCCTGTGCTGGTCATGGTCCTCACTACTCTCATTCTCATATTAGTGTGTGCTTGGCACTGGAGAAACAGAAAGAAAAAAACTGAAGGCACCTATGACTTACCTT
ACTGGGACCGGGCAGGTTGGTGGAAAGGAATGAAGCAGTTTCTTCCTGCAAAAGCAGTGGACCATGAGGAAACCCCAGTTCGCTATAGCAGCAGCGAAGTTAATCACCTGAGTCCAAGAGAAGTCACCACAGTGCTGCAGGCTGACTCTG
CAGAGTATGCTCAGCCACTGGTAGGAGGAATTGTTGGTACACTTCATCAAAGATCTACCTTTAAACCAGAAGAAGGAAAAGAAGCAGGCTATGCAGACCTAGATCCTTACAACTCACCAGGGCAGGAAGTTTATCATGCCTATGCTGAAC
CACTCCCAATTACGGGGCCTGAGTATGCAACCCCAATCATCATGGACATGTCAGGGCACCCCACAACTTCAGTTGGTCAGCCCTCCACATCCACTTTCAAGGCTACGGGGAACCAACCTCCCCCACTAGTGGGAACTTACAATACACTTC
TCTCCAGGACTGACAGCTGCTCCTCAGCCCAGGCCCAGTATGATACCCCGAAAGCTGGGAAGCCAGGTCTACCTGCCCCAGACGAATTGGTGTACCAGGTGCCACAGAGCACACAAGAAGTATCAGGAGCAGGAAGGGATGGGGAATGTG
ATGTTTTTAAAGAAATCCTTTGAAGATGATGCTGCTTTTTACAAAGCATCGTTTTAAAGCACATGGCCTTTTTTTTTTAATTATTAGTGGTAGTAATATATAGAATGTATTACATAACTGTCACTGAAGTGGTTGGGGAAAATGTGGTGA
CTGAGGTACAGGAAACTACTAATCTTGCCATCTTGCTTTAAGGTGTTATGGTGGCACAGTTACTGCTCGCCTGTTAAATTTCAAATGTCCTGTTTGATACTACTGTAGAACACTATTTTTAATACAGAAAAAGCTCCCTATAATGCACTT
CAGAGAAATTAAAAATCACAGAGTATTTATTACCAATGCTGCAGGTACATTAATGAACTCGAGATGGCTCTGTAAGCCTGACTGGCAATAACGCACGGTACTGTTCTTGAAATACCTAATGGCTTGAAATTCTAGTCTGTTTGTGAAAGA
TGGGTACTATCATGATTTCCTCTTCTATTCCTATATTCTTTTCTGGATTTTTTTTAATAATTAGTGATATAAGCATTGTTTTTATTGCAGCCATATCCACTTATCCATCTTAAGATCTGTAGCTGGGATTTTCTGACTTGTAATGAGCAG
GGGGATTGCTTTTTCACTTTGTGACACTCTTTAGAGCTTTAATGCTTCACAGTATATGGCCTGGTCTCATCCTTGCGTGTTCCACTTGAGGCCCTTTGGTGTCTTGCCCCATTCTTGTGTTTATAAAATGTTTGAGTATTTCTGATGAGT
GATGCTTGCCTTAGTCTCATGAATTCAGATCCCTTCATGTCCTTTAAGTATGCTCCTCAATGTGTAAACAGGAACAACTTTATGATTTGAAAGCTTTAAAGGAGATTCTTCTCCCACCCCCAACTTTATTTGCAATGGGATTTTTCCTAG
GAGAGTTATGAAAAGTTGAAGGCTTCTAAGGGAATACTGTAAACATGACCCACTTATATTTATCACAGTGAAAGGCAAAATTATTCACTCAGAAGTAATATAAATTACCTCTTTAAAAAGTAACCAGAATTTGTCCTTTTTGGTTTTATA
CATTCACAAACATATACATTTTTCTTGAGTCTCAAGGTATTTTATATTTTTAGTCAGAAAAAATAATTTTTCATTTCAGTTTTCCATAAACTGTTACACAAAATATAAACCTAACGTGTATTTTTCAGGACTGCGTGATCGTGCACTTTG
TGTGGTAAGAGGTTTGAGTAGTCCTATATGTCACCTAGGGAACAGACATTATAGCTTACTAGCAAATGAATATTCATGCCTTGTTTTTGATACCTCCTGGCAGCTTCCATGTCACCACTTGTTCATACCTGCCCAGAGCTAGTTTTAGAC
ATGGCAAAATAGAAATCATCTGTAATTTATTAGCTAACAATGTAAAACCATCTTTTAAAGCCTTCAGACTGTCAAGACGACATGAGCAGCTCACCATATGATAAAAATACATAAATTTGACATTCCCTCTTCCATAAACCTTTGTTTGTA
GATTTAATGTTGAACAGTACTTTTCCATAAAGTTCTAGTCACTTCTGTTGGCCTGAGCCACCAGATTATGATGTTGCCAGAATTCACTCAATTTGAATAAAGATGAACAGTATTTGTTTTCTTGTTTCCATGAATTATATCAGTATTCTA
AAACATCGCTTCAGAAAGAGAACTGTTTATTTCTGCAGGCTTCCTGTCCTTTTGTGGTATGGTTTTTTGGCCTTATTTTCACTGGCTTTTCCTTCTCCAAACTTTGAGGCGTGATTTCATTCATTGAAGAATCAATACATATTTTGTTTC
AAAATGTTTGAAACAAAAGACATAGATGGTAGACTTTTATTAAAACATATATGGATGTGGAAAGCACATATATTAATGCAGTCATCCCTTTTCAGGTGGGAAGAGAGCAAACCAGTTGATTTTTTAATTCATCCTTAGTACACAGAGAAT
ATACTTTTCCTCAAGTAATATACCTGTTTGAAGCTTTAAGAGAGATGTTTTTGGTAACTATTTCATTTTCCCAAAGAAGTTTGCTATTCTTGTGTTAATTGTGTATACCTGATTGTTTTTTCCTGGAGGTTTTTGTTGTTGTTGTTTAGT
TTTGGGTTTTTTTTTTTTTAAGAGGGGCAAGTGTTTTCTGAAATGATGCATATTTTAAGACTCGATTCATATTGCCACTGTGCTATCCTTGAACTACCAATAATTTTTATAAAATATCTAGTTTTTACTACTTTTATATAAACTTTACTT
TCCAGATGAAGAGCTGAGCCTGATTCAAATGGTTTTTCTGCTTTATACTTCTTTTTAGTTCATTGGTTTTTATAGTAGAGGTTTTCTATTTTTTTTTTTTTTTTTTTTACTACATTTATATGTCTGATACATATACGGCTTTGGAGACAA
TCAAGTAACAACTGAAAATGTGAAAGTAACCATATCTGACAAAATTCCCTTGAATTTTTATCCTTTGCTTGCAACATTTAAGACTCAAAGTCACTGGTATATTGGATTAAGTTTTTTCCTGTTAATGCAATTATAGAAATACATCGGAGA
CACAACAAATGTGGCCATTACAGGTTTCATAAAATTACACTGACTTGGCTGTTACTTGATCTTAGGAAACAGCACAGTTTAAGATATTGTGAATTCTGACTTATACTTTATTAAATGCTGTAAATCTAAATAGATCCTGTTGGATGTGAT
GGGTCTAGTCCAGTTTATTTAAGTTCATGTTTCACTGTTTGCACTTTGCATTGAACAATGGGTTTATTCGCTGATGTAAACGGTTCGAGTGAAGAATTAATGCAGTAAGTATGACAACACATACACACTTGCCTCTCCCCATCTCCAGAA
GAGGGGAGCAGAGTCCGAGCTTATCTAAATATGAATGTGGCCACAAAGCTGTGGAAGGTGACAAAGCTTAAACACCTTTGCCCTGGCTCTGCATTGTCACCTAGAGAGCAAGAGGTCTATAGAAACATCATGTCACATGAAACGATTCTC
TGCTTTTTGGTTCTGAACTTGAAGTCCCTAAACTGCAAAATCTAAGAGTTGGGTGGTTATTAAAATGCTTTTAAAGTCAACTGTGGCACCAATTCTAATGTAATCCAACTTGTGACTGTTTTTTTTTGTTTTGTTTTGTTTTTGTGTGTG
TGTGTGTGGCACTGGGAAAAGTGGAAACAAACATGTATTGAAATACATATTGGAAATAAAAATGGTTTGAGCGTCAGTGATATTCTCCCAGAATGTACTTATCTTACCTCGGCATGTACTGTAGTCACTCAGTATTTGTATATGTTGCTA
GAATTTAGATTGTAAAATAGTGAAATTTTAATGTGTTCATTTGTTTTTAATGTATATATGTCTTGCTCAGATTATTTGGTTTAAATAAAACAACCTTGAGGTTTGTAGCTTTTCCTTATACTATAAAATGCCAGATTCTTCTATTTTAAC
CTCA

>INTS6_DCBLD2_ENST00000491723_ENST00000326857_52025160_98600611 length=3754nt 
 Breakpoint=0nt
GTGATGGATGTGGACACACTGTACTAGGCCCTGAGAGTGGAACCCTTACATCCATAAACTACCCACAGACCTATCCCAACAGCACTGTTTGTGAATGGGAGATCCGTGTAAAGATGGGAGAGAGAGTTCGCATCAAATTTGGTGACTTTG
ACATTGAAGATTCTGATTCTTGTCACTTTAATTACTTGAGAATTTATAATGGAATTGGAGTCAGCAGAACTGAAATAGGCAAATACTGTGGTCTGGGGTTGCAAATGAACCATTCAATTGAATCAAAAGGCAATGAAATCACATTGCTGT
TCATGAGTGGAATCCATGTTTCTGGACGCGGATTTTTGGCCTCATACTCTGTTATAGATAAACAAGATCTAATTACTTGTTTGGACACTGCATCCAATTTTTTGGAACCTGAGTTCAGTAAGTACTGCCCAGCTGGTTGTCTGCTTCCTT
TTGCTGAGATATCTGGAACAATTCCTCATGGATATAGAGATTCCTCGCCATTGTGCATGGCTGGTGTGCATGCAGGAGTAGTGTCAAACACGTTGGGCGGCCAAATCAGTGTTGTAATTAGTAAAGGTATCCCCTATTATGAAAGTTCTT
TGGCTAACAACGTCACATCTGTGGTGGGACACTTATCTACAAGTCTTTTTACATTTAAGACAAGTGGATGTTATGGAACACTGGGGATGGAGTCTGGTGTGATCGCGGATCCTCAAATAACAGCATCATCTGTGCTGGAGTGGACTGACC
ACACAGGGCAAGAGAACAGTTGGAAACCCAAAAAAGCCAGGCTGAAAAAACCTGGACCGCCTTGGGCTGCTTTTGCCACTGATGAATACCAGTGGTTACAAATAGATTTGAATAAGGAAAAGAAAATAACAGGCATTATAACCACTGGAT
CCACCATGGTGGAGCACAATTACTATGTGTCTGCCTACAGAATCCTGTACAGTGATGATGGGCAGAAATGGACTGTGTACAGAGAGCCTGGTGTGGAGCAAGATAAGATATTTCAAGGAAACAAAGATTATCACCAGGATGTGCGTAATA
ACTTTTTGCCACCAATTATTGCACGTTTTATTAGAGTGAATCCTACCCAATGGCAGCAGAAAATTGCCATGAAAATGGAGCTGCTCGGATGTCAGTTTATTCCTAAAGGTCGTCCTCCAAAACTTACTCAACCTCCACCTCCTCGGAACA
GCAATGACCTCAAAAACACTACAGCCCCTCCAAAAATAGCCAAAGGTCGTGCCCCAAAATTTACGCAACCACTACAACCTCGCAGTAGCAATGAATTTCCTGCACAGACAGAACAAACAACTGCCAGTCCTGATATCAGAAATACTACCG
TAACTCCAAATGTAACCAAAGATGTAGCGCTGGCTGCAGTTCTTGTCCCTGTGCTGGTCATGGTCCTCACTACTCTCATTCTCATATTAGTGTGTGCTTGGCACTGGAGAAACAGAAAGAAAAAAACTGAAGGCACCTATGACTTACCTT
ACTGGGACCGGGCAGGTTTTTATTTAATGGTCTCTTTGGCTTGCCGTCACAATGAAGGTTGGTGGAAAGGAATGAAGCAGTTTCTTCCTGCAAAAGCAGTGGACCATGAGGAAACCCCAGTTCGCTATAGCAGCAGCGAAGTTAATCACC
TGAGTCCAAGAGAAGTCACCACAGTGCTGCAGGCTGACTCTGCAGAGTATGCTCAGCCACTGGTAGGAGGAATTGTTGGTACACTTCATCAAAGATCTACCTTTAAACCAGAAGAAGGAAAAGAAGCAGGCTATGCAGACCTAGATCCTT
ACAACTCACCAGGGCAGGAAGTTTATCATGCCTATGCTGAACCACTCCCAATTACGGGGCCTGAGTATGCAACCCCAATCATCATGGACATGTCAGGGCACCCCACAACTTCAGTTGGTCAGCCCTCCACATCCACTTTCAAGGCTACGG
GGAACCAACCTCCCCCACTAGTGGGAACTTACAATACACTTCTCTCCAGGACTGACAGCTGCTCCTCAGCCCAGGCCCAGTATGATACCCCGAAAGCTGGGAAGCCAGGTCTACCTGCCCCAGACGAATTGGTGTACCAGGTGCCACAGA
GCACACAAGAAGTATCAGGAGCAGGAAGGGATGGGGAATGTGATGTTTTTAAAGAAATCCTTTGAAGATGATGCTGCTTTTTACAAAGCATCGTTTTAAAGCACATGGCCTTTTTTTTTTAATTATTAGTGGTAGTAATATATAGAATGT
ATTACATAACTGTCACTGAAGTGGTTGGGGAAAATGTGGTGACTGAGGTACAGGAAACTACTAATCTTGCCATCTTGCTTTAAGGTGTTATGGTGGCACAGTTACTGCTCGCCTGTTAAATTTCAAATGTCCTGTTTGATACTACTGTAG
AACACTATTTTTAATACAGAAAAAGCTCCCTATAATGCACTTCAGAGAAATTAAAAATCACAGAGTATTTATTACCAATGCTGCAGGTACATTAATGAACTCGAGATGGCTCTGTAAGCCTGACTGGCAATAACGCACGGTACTGTTCTT
GAAATACCTAATGGCTTGAAATTCTAGTCTGTTTGTGAAAGATGGGTACTATCATGATTTCCTCTTCTATTCCTATATTCTTTTCTGGATTTTTTTTAATAATTAGTGATATAAGCATTGTTTTTATTGCAGCCATATCCACTTATCCAT
CTTAAGATCTGTAGCTGGGATTTTCTGACTTGTAATGAGCAGGGGGATTGCTTTTTCACTTTGTGACACTCTTTAGAGCTTTAATGCTTCACAGTATATGGCCTGGTCTCATCCTTGCGTGTTCCACTTGAGGCCCTTTGGTGTCTTGCC
CCATTCTTGTGTTTATAAAATGTTTGAGTATTTCTGATGAGTGATGCTTGCCTTAGTCTCATGAATTCAGATCCCTTCATGTCCTTTAAGTATGCTCCTCAATGTGTAAACAGGAACAACTTTATGATTTGAAAGCTTTAAAGGAGATTC
TTCTCCCACCCCCAACTTTATTTGCAATGGGATTTTTCCTAGGAGAGTTATGAAAAGTTGAAGGCTTCTAAGGGAATACTGTAAACATGACCCACTTATATTTATCACAGTGAAAGGCAAAATTATTCACTCAGAAGTAATATAAATTAC
CTCTTTAAAAAGTAACCAGAATTTGTCCTTTTTGGTTTTATACATTCACAAACATATACATTTTTCTTGAGTCTCAAGGTATTTTATATTTTTAGTCAGAAAAAATAATTTTTCATTTCAGTTTTCCATAAACTGTTACACAAAATATAA
ACCTAACGTGTATTTTTCAGGACTGCGTGATCGTGCACTTTGTGTGGTAAGAGGTTTGAGTAGTCCTATATGTCACCTAGGGAACAGACATTATAGCTTACTAGCAAATGAATATTCATGCCTTGTTTTTGATACCTCCTGGCAGCTTCC
ATGTCACCACTTGTTCATACCTGCCCAGAGCTAGTTTTAGACATGGCAAAATAGAAATCATCTGTAATTTATTAGCTAACAATGTAAAACCATCTTTTAAAGCCTTCAGACTGTCAAGACGACATGAGCAGCTCACCATATGATAAAAAT
ACATAAATTTGACATTCCCTCTTCCATAAACCTTTGTTTGTAGATTTAATGTTGAACAGTACTTTTCCATAAAGTTCTAGTCACTTCTGTTGGCCTGAGCCACCAGATTATGATGTTGCCAGAATTCACTCAATTTGAATAAAGATGAAC
AGTA

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for INTS6_DCBLD2

In-frame Fusion Protein Sequences.

N-Truncated Protein (5UTR-3CDS) Sequences

>INTS6_DCBLD2_ENST00000425000_ENST00000326840_52025160_98600611 length=368nt
MDSTGSRLDYRRYADTLFDILVAGSMLAPGGTRIDDGDKTKMTNHCVFSANEDHETIRNYAQVFNKLIRRYKYLEKAFEDEMKKLLLFLKAFSETEQTKLAMLSGILLGNGTLPATILTSLFTDSLVKEGIAASFAVKLFKAWMAEKDAN
SVTSSLRKANLDKRLLELFPVNRQSVDHFAKYFTDAGLKELSDFLRVQQSLGTRKELQKELQERLSQECPIKEVVLYVKEEMKRNDLPETAVIGLLWTCIMNAVEWNKKEELVAEQALKHLKQYAPLLAVFSSQGQSELILLQKVQEYCY
DNIHFMKAFQKIVVLFYKADVLSEEAILKWYKEAHVAKGKSVFLDQMKKFVEWLQNAEEESESEGEEN

>INTS6_DCBLD2_ENST00000425000_ENST00000326857_52025160_98600611 length=669nt
MGERVRIKFGDFDIEDSDSCHFNYLRIYNGIGVSRTEIGKYCGLGLQMNHSIESKGNEITLLFMSGIHVSGRGFLASYSVIDKQDLITCLDTASNFLEPEFSKYCPAGCLLPFAEISGTIPHGYRDSSPLCMAGVHAGVVSNTLGGQISV
VISKGIPYYESSLANNVTSVVGHLSTSLFTFKTSGCYGTLGMESGVIADPQITASSVLEWTDHTGQENSWKPKKARLKKPGPPWAAFATDEYQWLQIDLNKEKKITGIITTGSTMVEHNYYVSAYRILYSDDGQKWTVYREPGVEQDKIF
QGNKDYHQDVRNNFLPPIIARFIRVNPTQWQQKIAMKMELLGCQFIPKGRPPKLTQPPPPRNSNDLKNTTAPPKIAKGRAPKFTQPLQPRSSNEFPAQTEQTTASPDIRNTTVTPNVTKDVALAAVLVPVLVMVLTTLILILVCAWHWRN
RKKKTEGTYDLPYWDRAGWWKGMKQFLPAKAVDHEETPVRYSSSEVNHLSPREVTTVLQADSAEYAQPLVGGIVGTLHQRSTFKPEEGKEAGYADLDPYNSPGQEVYHAYAEPLPITGPEYATPIIMDMSGHPTTSVGQPSTSTFKATGN
QPPPLVGTYNTLLSRTDSCSSAQAQYDTPKAGKPGLPAPDELVYQVPQSTQEVSGAGRDGECDVFKEIL

>INTS6_DCBLD2_ENST00000491723_ENST00000326840_52025160_98600611 length=368nt
MDSTGSRLDYRRYADTLFDILVAGSMLAPGGTRIDDGDKTKMTNHCVFSANEDHETIRNYAQVFNKLIRRYKYLEKAFEDEMKKLLLFLKAFSETEQTKLAMLSGILLGNGTLPATILTSLFTDSLVKEGIAASFAVKLFKAWMAEKDAN
SVTSSLRKANLDKRLLELFPVNRQSVDHFAKYFTDAGLKELSDFLRVQQSLGTRKELQKELQERLSQECPIKEVVLYVKEEMKRNDLPETAVIGLLWTCIMNAVEWNKKEELVAEQALKHLKQYAPLLAVFSSQGQSELILLQKVQEYCY
DNIHFMKAFQKIVVLFYKADVLSEEAILKWYKEAHVAKGKSVFLDQMKKFVEWLQNAEEESESEGEEN

>INTS6_DCBLD2_ENST00000491723_ENST00000326857_52025160_98600611 length=669nt
MGERVRIKFGDFDIEDSDSCHFNYLRIYNGIGVSRTEIGKYCGLGLQMNHSIESKGNEITLLFMSGIHVSGRGFLASYSVIDKQDLITCLDTASNFLEPEFSKYCPAGCLLPFAEISGTIPHGYRDSSPLCMAGVHAGVVSNTLGGQISV
VISKGIPYYESSLANNVTSVVGHLSTSLFTFKTSGCYGTLGMESGVIADPQITASSVLEWTDHTGQENSWKPKKARLKKPGPPWAAFATDEYQWLQIDLNKEKKITGIITTGSTMVEHNYYVSAYRILYSDDGQKWTVYREPGVEQDKIF
QGNKDYHQDVRNNFLPPIIARFIRVNPTQWQQKIAMKMELLGCQFIPKGRPPKLTQPPPPRNSNDLKNTTAPPKIAKGRAPKFTQPLQPRSSNEFPAQTEQTTASPDIRNTTVTPNVTKDVALAAVLVPVLVMVLTTLILILVCAWHWRN
RKKKTEGTYDLPYWDRAGWWKGMKQFLPAKAVDHEETPVRYSSSEVNHLSPREVTTVLQADSAEYAQPLVGGIVGTLHQRSTFKPEEGKEAGYADLDPYNSPGQEVYHAYAEPLPITGPEYATPIIMDMSGHPTTSVGQPSTSTFKATGN
QPPPLVGTYNTLLSRTDSCSSAQAQYDTPKAGKPGLPAPDELVYQVPQSTQEVSGAGRDGECDVFKEIL

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for INTS6_DCBLD2

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for INTS6_DCBLD2

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		OV	TCGA-23-1114-01B	INTS6	chr13	52025160	-	DCBLD2	chr3	98600611	-
ChimerDB		OV	TCGA-23-1114	INTS6	chr13	52025160	-	DCBLD2	chr3	98600611	-
WashU		OV	TCGA-23-1114-01B	INTS6	chr13	52025161	-	DCBLD2	chr3	98600611	-

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for INTS6_DCBLD2

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status