Home

Download

Statistics

Examples

About

Contact

	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:ATP2C1_NDUFB4 (FusionGDB2 ID:HG27032TG4710)

Fusion Gene Summary for ATP2C1_NDUFB4

Fusion gene summary

Fusion gene information	Fusion gene name: ATP2C1_NDUFB4
	Fusion gene ID: hg27032tg4710
		Hgene	Tgene
	Gene symbol	ATP2C1	NDUFB4
	Gene ID	27032	4710
	Gene name	ATPase secretory pathway Ca2+ transporting 1	NADH:ubiquinone oxidoreductase subunit B4
	Synonyms	ATP2C1A\|BCPM\|HHD\|PMR1\|SPCA1\|hSPCA1	B15\|CI-B15
	Cytomap	3q22.1	3q13.33
	Type of gene	protein-coding	protein-coding
	Description	calcium-transporting ATPase type 2C member 1ATP-dependent Ca(2+) pump PMR1ATPase 2C1ATPase, Ca(2+)-sequesteringATPase, Ca++ transporting, type 2C, member 1Ca(2+)/Mn(2+)-ATPase 2C1HUSSY-28secretory pathway Ca(2+)-transporting ATPase type 1secretory	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDaNADH-ubiquinone oxidoreductase B15 subunitcomplex I B15 subunitcomplex I-B15
	Modification date	20240407	20240411
	UniProtAcc	.	O95168
	Ensembl transtripts involved in fusion gene	ENST00000328560, ENST00000359644, ENST00000422190, ENST00000428331, ENST00000508532, ENST00000510168, ENST00000393221, ENST00000504381, ENST00000504948, ENST00000505330, ENST00000507488, ENST00000509150, ENST00000513801, ENST00000533801,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 20 X 21 X 17=7140	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 3 X 8 X 6=144
	# samples	71	8
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(71/714010)=-3.33003314452442 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(8/14410)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ATP2C1 [Title/Abstract] AND NDUFB4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ATP2C1(130613619)-NDUFB4(120319957), # samples:1

Fusion gene breakpoints across ATP2C1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NDUFB4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Breakpoints for ATP2C1_NDUFB4

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ATP2C1	chr3	130613619	NDUFB4	chr3	130613619
ATP2C1	chr3	130569772	NDUFB4	chr3	130569772
ATP2C1	chr3	130613619	NDUFB4	chr3	120319958
ATP2C1	chr3	130894775	NDUFB4	chr3	120601111

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

Top

Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for ATP2C1_NDUFB4

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NDUFB4 O95168

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ATP2C1	GO:0006816	calcium ion transport	12810057
Hgene	ATP2C1	GO:0006874	intracellular calcium ion homeostasis	12810057
Tgene	NDUFB4	GO:0006979	response to oxidative stress	12857734

Top

Fusion Genomic Features for ATP2C1_NDUFB4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ATP2C1	chr3	130613619	+	NDUFB4	chr3	120319957	+	1.05e-04	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

Top

Fusion Gene ORF Annotations for ATP2C1_NDUFB4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000328560	ENST00000485064	ATP2C1	chr3	130613619	+	NDUFB4	chr3	120319957	+
Frame-shift	ENST00000359644	ENST00000485064	ATP2C1	chr3	130613619	+	NDUFB4	chr3	120319957	+
Frame-shift	ENST00000422190	ENST00000485064	ATP2C1	chr3	130613619	+	NDUFB4	chr3	120319957	+
Frame-shift	ENST00000428331	ENST00000485064	ATP2C1	chr3	130613619	+	NDUFB4	chr3	120319957	+
Frame-shift	ENST00000508532	ENST00000485064	ATP2C1	chr3	130613619	+	NDUFB4	chr3	120319957	+
Frame-shift	ENST00000510168	ENST00000485064	ATP2C1	chr3	130613619	+	NDUFB4	chr3	120319957	+
In-frame	ENST00000328560	ENST00000184266	ATP2C1	chr3	130613619	+	NDUFB4	chr3	120319957	+
In-frame	ENST00000359644	ENST00000184266	ATP2C1	chr3	130613619	+	NDUFB4	chr3	120319957	+
In-frame	ENST00000422190	ENST00000184266	ATP2C1	chr3	130613619	+	NDUFB4	chr3	120319957	+
In-frame	ENST00000428331	ENST00000184266	ATP2C1	chr3	130613619	+	NDUFB4	chr3	120319957	+
In-frame	ENST00000508532	ENST00000184266	ATP2C1	chr3	130613619	+	NDUFB4	chr3	120319957	+
In-frame	ENST00000510168	ENST00000184266	ATP2C1	chr3	130613619	+	NDUFB4	chr3	120319957	+

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000328560	ENST00000184266	ATP2C1	chr3	130613619	NDUFB4	chr3	120319957	7.93e-01	2.07e-01
ENST00000359644	ENST00000184266	ATP2C1	chr3	130613619	NDUFB4	chr3	120319957	9.05e-01	9.48e-02
ENST00000422190	ENST00000184266	ATP2C1	chr3	130613619	NDUFB4	chr3	120319957	9.05e-01	9.48e-02
ENST00000428331	ENST00000184266	ATP2C1	chr3	130613619	NDUFB4	chr3	120319957	8.22e-01	1.78e-01
ENST00000508532	ENST00000184266	ATP2C1	chr3	130613619	NDUFB4	chr3	120319957	8.41e-01	1.59e-01
ENST00000510168	ENST00000184266	ATP2C1	chr3	130613619	NDUFB4	chr3	120319957	8.24e-01	1.76e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

Top

Fusion Protein Retained/Non-Retained Functional Features for ATP2C1_NDUFB4

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

ATP2C1_NDUFB4_chr3-130613619_chr3-120319957.png

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NDUFB4

chr3:130613619

chr3:120319957

ENST00000184266

O95168

88_105

60.0

130.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATP2C1

chr3:130613619

chr3:120319957

ENST00000328560

P98194

124_262

2.0

889.0

Topological domain

Cytoplasmic

Hgene

ATP2C1

chr3:130613619

chr3:120319957

ENST00000328560

P98194

1_70

2.0

889.0

Topological domain

Cytoplasmic

Hgene

ATP2C1

chr3:130613619

chr3:120319957

ENST00000328560

P98194

283_294

2.0

889.0

Topological domain

Lumenal

Hgene

ATP2C1

chr3:130613619

chr3:120319957

ENST00000328560

P98194

313_699

2.0

889.0

Topological domain

Cytoplasmic

Hgene

ATP2C1

chr3:130613619

chr3:120319957

ENST00000328560

P98194

720_729

2.0

889.0

Topological domain

Lumenal

Hgene

ATP2C1

chr3:130613619

chr3:120319957

ENST00000328560

P98194

751_770

2.0

889.0

Topological domain

Cytoplasmic

Hgene

ATP2C1

chr3:130613619

chr3:120319957

ENST00000328560

P98194

794_808

2.0

889.0

Topological domain

Lumenal

Hgene

ATP2C1

chr3:130613619

chr3:120319957

ENST00000328560

P98194

829_841

2.0

889.0

Topological domain

Cytoplasmic

Hgene

ATP2C1

chr3:130613619

chr3:120319957

ENST00000328560

P98194

861_875

2.0

889.0

Topological domain

Lumenal

Hgene

ATP2C1

chr3:130613619

chr3:120319957

ENST00000328560

P98194

897_919

2.0

889.0

Topological domain

Cytoplasmic

Hgene

ATP2C1

chr3:130613619

chr3:120319957

ENST00000328560

P98194

92_104

2.0

889.0

Topological domain

Lumenal

Hgene

ATP2C1

chr3:130613619

chr3:120319957

ENST00000328560

P98194

105_123

2.0

889.0

Transmembrane

Helical%3B Name%3D2

Hgene

ATP2C1

chr3:130613619

chr3:120319957

ENST00000328560

P98194

263_282

2.0

889.0

Transmembrane

Helical%3B Name%3D3

Hgene

ATP2C1

chr3:130613619

chr3:120319957

ENST00000328560

P98194

295_312

2.0

889.0

Transmembrane

Helical%3B Name%3D4

Hgene

ATP2C1

chr3:130613619

chr3:120319957

ENST00000328560

P98194

700_719

2.0

889.0

Transmembrane

Helical%3B Name%3D5

Hgene

ATP2C1

chr3:130613619

chr3:120319957

ENST00000328560

P98194

71_91

2.0

889.0

Transmembrane

Helical%3B Name%3D1

Hgene

ATP2C1

chr3:130613619

chr3:120319957

ENST00000328560

P98194

730_750

2.0

889.0

Transmembrane

Helical%3B Name%3D6

Hgene

ATP2C1

chr3:130613619

chr3:120319957

ENST00000328560

P98194

771_793

2.0

889.0

Transmembrane

Helical%3B Name%3D7

Hgene

ATP2C1

chr3:130613619

chr3:120319957

ENST00000328560

P98194

809_828

2.0

889.0

Transmembrane

Helical%3B Name%3D8

Hgene

ATP2C1

chr3:130613619

chr3:120319957

ENST00000328560

P98194

876_896

2.0

889.0

Transmembrane

Helical%3B Name%3D10

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Fusion Transcript Sequence for ATP2C1_NDUFB4

In-frame Fusion Transcript Sequences.

>ATP2C1_NDUFB4_ENST00000328560_ENST00000184266_130613619_120319957 length=768nt 
 Breakpoint=328nt
GCTGGCGTGAGCTGGGGACGTTGCGGGCACACGACGGGGCGGGTGCGGGATCTTGGGGAGGGGGGCTCCCGAGATAGTGGCTGGGCGGGGAACTCCTTCCTCAGCCTCTCGTCAGCGCCGCTTCTCCTGGTTTCTCTTGCAGATGCTGCT
GCTAGGGGTGGTGGGAGCAGCCGTGGGACGCGTGGCCGGGAGCGGGGGTGACAGCCTGGGATTCCGGGGGCTTCTCTTCCTTGTCCTCCTCCTCTCCTCTCTATTCCCAGTGTGGCCGTGGCTGACACTAAAGACTTTGTAGCCATCAAC
CCGAGTGCAGTTTCGATGGAAAATGAAGGAAAATCCTGCCTTGCTTCGTTGGGCCTATGCAAGAACAATAAATGTCTATCCTAATTTCAGACCCACTCCTAAAAACTCACTCATGGGAGCTCTGTGTGGATTTGGGCCCCTCATCTTCAT
TTATTATATTATCAAAACTGAGAGGGATAGGAAAGAAAAACTTATCCAGGAAGGAAAATTGGATCGAACATTTCACCTCTCATATTAAGTCTGGCAATGATGACTATATGTATTCCTGCCTAAATAAATCATCTATTAATCATTAAGTAG
TAGTTTCTCTTTCTTAGTATTACCTTGATTCAATGTTAAAAACTATTAACACCCTAACAACACAGAAGCAGACGCAGCCCGTGTTGGGAATCTGCTGTCAGAGTGACAGCAAACATTTGCTGTACATTGAATGAATGAACATAAACTTCA
TTAAACTGTGAGCTCTTA

>ATP2C1_NDUFB4_ENST00000359644_ENST00000184266_130613619_120319957 length=575nt 
 Breakpoint=135nt
GGGGGTGACAGCCTGGGATTCCGGGGGCTTCTCTTCCTTGTCCTCCTCCTCTCCTCTCTATTCCCAGTGTGGCCGTGGCTGACACTAAAGACTTTGTAGCCATCAACCCGAGTGCAGTTTCGATGGAAAATGAAGGAAAATCCTGCCTTG
CTTCGTTGGGCCTATGCAAGAACAATAAATGTCTATCCTAATTTCAGACCCACTCCTAAAAACTCACTCATGGGAGCTCTGTGTGGATTTGGGCCCCTCATCTTCATTTATTATATTATCAAAACTGAGAGGGATAGGAAAGAAAAACTT
ATCCAGGAAGGAAAATTGGATCGAACATTTCACCTCTCATATTAAGTCTGGCAATGATGACTATATGTATTCCTGCCTAAATAAATCATCTATTAATCATTAAGTAGTAGTTTCTCTTTCTTAGTATTACCTTGATTCAATGTTAAAAAC
TATTAACACCCTAACAACACAGAAGCAGACGCAGCCCGTGTTGGGAATCTGCTGTCAGAGTGACAGCAAACATTTGCTGTACATTGAATGAATGAACATAAACTTCATTAAACTGTGAGCTCTTA

>ATP2C1_NDUFB4_ENST00000422190_ENST00000184266_130613619_120319957 length=575nt 
 Breakpoint=135nt
GGGGGTGACAGCCTGGGATTCCGGGGGCTTCTCTTCCTTGTCCTCCTCCTCTCCTCTCTATTCCCAGTGTGGCCGTGGCTGACACTAAAGACTTTGTAGCCATCAACCCGAGTGCAGTTTCGATGGAAAATGAAGGAAAATCCTGCCTTG
CTTCGTTGGGCCTATGCAAGAACAATAAATGTCTATCCTAATTTCAGACCCACTCCTAAAAACTCACTCATGGGAGCTCTGTGTGGATTTGGGCCCCTCATCTTCATTTATTATATTATCAAAACTGAGAGGGATAGGAAAGAAAAACTT
ATCCAGGAAGGAAAATTGGATCGAACATTTCACCTCTCATATTAAGTCTGGCAATGATGACTATATGTATTCCTGCCTAAATAAATCATCTATTAATCATTAAGTAGTAGTTTCTCTTTCTTAGTATTACCTTGATTCAATGTTAAAAAC
TATTAACACCCTAACAACACAGAAGCAGACGCAGCCCGTGTTGGGAATCTGCTGTCAGAGTGACAGCAAACATTTGCTGTACATTGAATGAATGAACATAAACTTCATTAAACTGTGAGCTCTTA

>ATP2C1_NDUFB4_ENST00000428331_ENST00000184266_130613619_120319957 length=681nt 
 Breakpoint=241nt
GGGAACTCCTTCCTCAGCCTCTCGTCAGCGCCGCTTCTCCTGGTTTCTCTTGCAGATGCTGCTGCTAGGGGTGGTGGGAGCAGCCGTGGGACGCGTGGCCGGGAGCGGGGGTGACAGCCTGGGATTCCGGGGGCTTCTCTTCCTTGTCCT
CCTCCTCTCCTCTCTATTCCCAGTGTGGCCGTGGCTGACACTAAAGACTTTGTAGCCATCAACCCGAGTGCAGTTTCGATGGAAAATGAAGGAAAATCCTGCCTTGCTTCGTTGGGCCTATGCAAGAACAATAAATGTCTATCCTAATTT
CAGACCCACTCCTAAAAACTCACTCATGGGAGCTCTGTGTGGATTTGGGCCCCTCATCTTCATTTATTATATTATCAAAACTGAGAGGGATAGGAAAGAAAAACTTATCCAGGAAGGAAAATTGGATCGAACATTTCACCTCTCATATTA
AGTCTGGCAATGATGACTATATGTATTCCTGCCTAAATAAATCATCTATTAATCATTAAGTAGTAGTTTCTCTTTCTTAGTATTACCTTGATTCAATGTTAAAAACTATTAACACCCTAACAACACAGAAGCAGACGCAGCCCGTGTTGG
GAATCTGCTGTCAGAGTGACAGCAAACATTTGCTGTACATTGAATGAATGAACATAAACTTCATTAAACTGTGAGCTCTTA

>ATP2C1_NDUFB4_ENST00000508532_ENST00000184266_130613619_120319957 length=855nt 
 Breakpoint=415nt
CAAAGCTGGGTTCGCGGCTGGCCCAGGAGTGCGGGGCGCGACTGGGCGGCCGGCGGCGGGGAGGGGCGGAGCGCAGGAGTCGGAGGCGGGAGCAGACCAGCACGGCCTCGCGGAGCCGGCCCGGCGGACCGTGACGGGTCCCCTCACCTC
CTCTTCTCTCCCCTCCCCGCCCGCCCTCTCTCCCTCCCTTCCTCCCTCCCGCTCGCTTCTTCTCACGCCGGGAGCAGGCTCCCGCCTCGCACCGCTGCCCCGCGAGCAGCTCCTCTTCTCCCGAGGCGCGCGGGGCGCCCCCGCGAGCCC
CGCGGCTGAGACCCCGCAGCCTGGAGGAGGGCTGTCCGGGGCTTTGGTGTGGCCGTGGCTGACACTAAAGACTTTGTAGCCATCAACCCGAGTGCAGTTTCGATGGAAAATGAAGGAAAATCCTGCCTTGCTTCGTTGGGCCTATGCAAG
AACAATAAATGTCTATCCTAATTTCAGACCCACTCCTAAAAACTCACTCATGGGAGCTCTGTGTGGATTTGGGCCCCTCATCTTCATTTATTATATTATCAAAACTGAGAGGGATAGGAAAGAAAAACTTATCCAGGAAGGAAAATTGGA
TCGAACATTTCACCTCTCATATTAAGTCTGGCAATGATGACTATATGTATTCCTGCCTAAATAAATCATCTATTAATCATTAAGTAGTAGTTTCTCTTTCTTAGTATTACCTTGATTCAATGTTAAAAACTATTAACACCCTAACAACAC
AGAAGCAGACGCAGCCCGTGTTGGGAATCTGCTGTCAGAGTGACAGCAAACATTTGCTGTACATTGAATGAATGAACATAAACTTCATTAAACTGTGAGCTCTTA

>ATP2C1_NDUFB4_ENST00000510168_ENST00000184266_130613619_120319957 length=996nt 
 Breakpoint=556nt
TCTCTCAGCGGAAGTAATAGTGACAAAGCTGGGTTCGCGGCTGGCCCAGGAGTGCGGGGCGCGACTGGGCGGCCGGCGGCGGGGAGGGGCGGAGCGCAGGAGTCGGAGGCGGGAGCAGACCAGCACGGCCTCGCGGAGCCGGCCCGGCGG
ACCGTGACGGGTCCCCTCACCTCCTCTTCTCTCCCCTCCCCGCCCGCCCTCTCTCCCTCCCTTCCTCCCTCCCGCTCGCTTCTTCTCACGCCGGGAGCAGGCTCCCGCCTCGCACCGCTGCCCCGCGAGCAGCTCCTCTTCTCCCGAGGC
GCGCGGGGCGCCCCCGCGAGCCCCGCGGCTGAGACCCCGCAGCCTGGAGGAGGGCTGTCCGGGGCTTTGGATGCTGCTGCTAGGGGTGGTGGGAGCAGCCGTGGGACGCGTGGCCGGGAGCGGGGGTGACAGCCTGGGATTCCGGGGGCT
TCTCTTCCTTGTCCTCCTCCTCTCCTCTCTATTCCCAGTGTGGCCGTGGCTGACACTAAAGACTTTGTAGCCATCAACCCGAGTGCAGTTTCGATGGAAAATGAAGGAAAATCCTGCCTTGCTTCGTTGGGCCTATGCAAGAACAATAAA
TGTCTATCCTAATTTCAGACCCACTCCTAAAAACTCACTCATGGGAGCTCTGTGTGGATTTGGGCCCCTCATCTTCATTTATTATATTATCAAAACTGAGAGGGATAGGAAAGAAAAACTTATCCAGGAAGGAAAATTGGATCGAACATT
TCACCTCTCATATTAAGTCTGGCAATGATGACTATATGTATTCCTGCCTAAATAAATCATCTATTAATCATTAAGTAGTAGTTTCTCTTTCTTAGTATTACCTTGATTCAATGTTAAAAACTATTAACACCCTAACAACACAGAAGCAGA
CGCAGCCCGTGTTGGGAATCTGCTGTCAGAGTGACAGCAAACATTTGCTGTACATTGAATGAATGAACATAAACTTCATTAAACTGTGAGCTCTTA

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

Top

Fusion Protein Sequence for ATP2C1_NDUFB4

In-frame Fusion Protein Sequences.

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

Top

Personalized Fusion Protein Sequence for ATP2C1_NDUFB4

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

Top

Fusion Gene Exprssed Samples for ATP2C1_NDUFB4

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		UCS	TCGA-N5-A4R8-01A	ATP2C1	chr3	130613619	+	NDUFB4	chr3	130613619	+
ChimerDB		UCS	TCGA-N5-A4R8	ATP2C1	chr3	130569772	+	NDUFB4	chr3	130569772	+
ChimerDB		UCS	TCGA-N5-A4R8	ATP2C1	chr3	130613619	+	NDUFB4	chr3	130613619	+
WashU		UCS	TCGA-N5-A4R8-01A	ATP2C1	chr3	130613619	+	NDUFB4	chr3	120319958	+
cBioPortal	UCS_TCGA_PAN_CAN_ATLAS_2018	UCS	TCGA-N5-A4R8-01	ATP2C1	chr3	130894775		NDUFB4	chr3	120601111

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

Top

Related Drugs for ATP2C1_NDUFB4

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Tgene	NDUFB4	O95168	DB00157	NADH		Small molecule	Approved\|Nutraceutical