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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:TMEM230_LMTK2 (FusionGDB2 ID:HG29058TG22853)

Fusion Gene Summary for TMEM230_LMTK2

Fusion gene summary

Fusion gene information	Fusion gene name: TMEM230_LMTK2
	Fusion gene ID: hg29058tg22853
		Hgene	Tgene
	Gene symbol	TMEM230	LMTK2
	Gene ID	29058	22853
	Gene name	transmembrane protein 230	lemur tyrosine kinase 2
	Synonyms	C20orf30\|HSPC274\|dJ1116H23.2.1	AATYK2\|BREK\|KPI-2\|KPI2\|LMR2\|PPP1R100\|cprk\|hBREK
	Cytomap	20p13-p12.3	7q21.3
	Type of gene	protein-coding	protein-coding
	Description	transmembrane protein 230UPF0414 transmembrane protein C20orf30	serine/threonine-protein kinase LMTK2CDK5/p35-regulated kinaseapoptosis-associated tyrosine kinase 2brain-enriched kinasecyclin-dependent kinase 5/p35-regulated kinasekinase/phosphatase/inhibitor 2protein phosphatase 1, regulatory subunit 100serine
	Modification date	20240305	20240411
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000202834, ENST00000342308, ENST00000379277, ENST00000379279, ENST00000379283, ENST00000379286, ENST00000492419,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 5 X 4 X 4=80	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 2 X 9 X 5=90
	# samples	7	10
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(7/8010)=-0.192645077942396 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(10/9010)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: TMEM230 [Title/Abstract] AND LMTK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TMEM230(5086833)-LMTK2(97820039), # samples:1

Fusion gene breakpoints across TMEM230 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LMTK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for TMEM230_LMTK2

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
TMEM230	chr20	5086833	LMTK2	chr7	97820039
TMEM230	chr20	5086833	LMTK2	chr7	5086833

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for TMEM230_LMTK2

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
TMEM230-LMTK2	Promoter / Enhancer Hijacking M6		Promoter swap alters transmembrane protein 230 secretory vesicle expression alongside LMTK2 (lemur tyrosine kinase 2), modifying secretory vesicular trafficking directly with transmembrane kinase survival signaling.		Pan-kinase inhibitors; secretory pathway blockers		Prostate and epithelial carcinomas

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
TMEM230-LMTK2	Promoter / Enhancer Hijacking	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 30761001; Title: Unraveling the Function of Lemur Tyrosine Kinase 2 Network.	Promoter swap alters transmembrane protein 230 secretory vesicle expression alongside LMTK2 (lemur tyrosine kinase 2), modifying secretory vesicular trafficking directly with transmembrane kinase survival signaling.	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 30761001; Title: Unraveling the Function of Lemur Tyrosine Kinase 2 Network.; PMID: 28040547; Title: Lemur tyrosine kinase 2 (LMTK2) is a determinant of cell sensitivity to apoptosis by regulating the levels of the BCL2 family members.	Pan-kinase inhibitors; secretory pathway blockers		Prostate and epithelial carcinomas	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 28040547; Title: Lemur tyrosine kinase 2 (LMTK2) is a determinant of cell sensitivity to apoptosis by regulating the levels of the BCL2 family members.; PMID: 30980866; Title: Lemur tyrosine kinase 2 acts as a positive regulator of NF-ÎºB activation and colon cancer cell proliferation.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	LMTK2	GO:0006468	protein phosphorylation	12393858
Tgene	LMTK2	GO:0018105	peptidyl-serine phosphorylation	16887929
Tgene	LMTK2	GO:0018107	peptidyl-threonine phosphorylation	16887929
Tgene	LMTK2	GO:0046777	protein autophosphorylation	12393858

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Fusion Genomic Features for TMEM230_LMTK2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+	1.44e-10	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+	1.44e-10	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for TMEM230_LMTK2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000492419	ENST00000297293	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+
Frame-shift	ENST00000202834	ENST00000297293	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+
Frame-shift	ENST00000342308	ENST00000297293	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+
Frame-shift	ENST00000379277	ENST00000297293	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+
Frame-shift	ENST00000379279	ENST00000297293	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+
Frame-shift	ENST00000379286	ENST00000297293	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+
In-frame	ENST00000379283	ENST00000297293	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000379283	ENST00000297293	TMEM230	chr20	5086833	LMTK2	chr7	97820039	568	203

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000492419	ENST00000297293	TMEM230	chr20	5086833	LMTK2	chr7	97820039	0	371

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000379283	ENST00000297293	TMEM230	chr20	5086833	LMTK2	chr7	97820039	2.13e-05	1.00e+00

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000492419	ENST00000297293	TMEM230	chr20	5086833	LMTK2	chr7	97820039	0.00e+00	1.21e-05

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for TMEM230_LMTK2

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

TMEM230_LMTK2_chr20-5086833_chr7-97820039.png

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM230

chr20:5086833

chr7:97820039

ENST00000379283

Q96A57

46_66

74.0

121.0

Transmembrane

Helical

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

Q8IWU2

1088_1100

332.6666666666667

1504.0

Compositional bias

Polar residues

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

Q8IWU2

1277_1296

332.6666666666667

1504.0

Compositional bias

Acidic residues

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

Q8IWU2

1409_1424

332.6666666666667

1504.0

Compositional bias

Acidic residues

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

Q8IWU2

1430_1448

332.6666666666667

1504.0

Compositional bias

Polar residues

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

Q8IWU2

597_606

332.6666666666667

1504.0

Compositional bias

Acidic residues

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

Q8IWU2

804_820

332.6666666666667

1504.0

Compositional bias

Polar residues

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

Q8IWU2

970_984

332.6666666666667

1504.0

Compositional bias

Low complexity

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

Q8IWU2

1013_1202

332.6666666666667

1504.0

Region

Disordered

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

Q8IWU2

1276_1317

332.6666666666667

1504.0

Region

Disordered

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

Q8IWU2

1372_1469

332.6666666666667

1504.0

Region

Disordered

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

Q8IWU2

597_622

332.6666666666667

1504.0

Region

Disordered

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

Q8IWU2

804_840

332.6666666666667

1504.0

Region

Disordered

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

Q8IWU2

875_898

332.6666666666667

1504.0

Region

Disordered

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

Q8IWU2

970_999

332.6666666666667

1504.0

Region

Disordered

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM230

chr20:5086833

chr7:97820039

ENST00000379283

Q96A57

79_99

74.0

121.0

Transmembrane

Helical

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

Q8IWU2

137_407

332.6666666666667

1504.0

Domain

Protein kinase

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

Q8IWU2

1_10

332.6666666666667

1504.0

Topological domain

Cytoplasmic

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

Q8IWU2

32_42

332.6666666666667

1504.0

Topological domain

Lumenal

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

Q8IWU2

64_1503

332.6666666666667

1504.0

Topological domain

Cytoplasmic

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

Q8IWU2

11_31

332.6666666666667

1504.0

Transmembrane

Helical

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

Q8IWU2

43_63

332.6666666666667

1504.0

Transmembrane

Helical

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for TMEM230_LMTK2

In-frame Fusion Transcript Sequences.

>TMEM230_LMTK2_ENST00000379283_ENST00000297293_5086833_97820039 length=8223nt 
 Breakpoint=568nt
TGGCACTTAAGCGGGCCATGCCATGCAACCTTGGGCGCTGCCAACCGTGGGCGAGCTCTGGGTGTGCGGGCGGCCTGGCGCGGCGCTCCGGTAAGGCGTGTGTGCGGCAGGGCGGGGACAGAACCGTCCTCTCGGGCTCTGGGCGTGTCC
GAGACCGCGCTCCCCGCCGAAATCAAGCTCCGAGTCATCCGTGTGGGGCATTCGTCCCCCCTGGCACAGTTGGCCTCTTTCCAGAAGCCCGTTTTGTTTGTTTTACGTCTAAATTCGCGTCGGTTCTTATTTCTCTCCCTGGCAAGGTCT
GAAGACGGGTAGGAGAATAACGTATGTAGAGCTGTGTCAGCGTGTTATGATGCCGTCCCGTACCAACCTGGCTACTGGAATCCCCAGTAGTAAAGTGAAATATTCAAGGCTCTCCAGCACAGACGATGGCTACATTGACCTTCAGTTTAA
GAAAACCCCTCCTAAGATCCCTTATAAGGCCATCGCACTTGCCACTGTGCTGTTTTTGATTGGCGCCTTTCTCATTATTATAGGCTCCCTCCTGCTGTCAGGCTACATCAGCAAAGGGGTCTCTGGGTGTGACACTTTGGGAGCTTTTTG
ACAATGCCGCACAGCCGTATTCAAACCTTTCCAACTTAGATGTCCTCAACCAAGTCATTAGAGAGAGAGACACAAAACTCCCGAAGCCCCAGCTGGAGCAGCCCTACTCTGATAGATGGTATGAAGTCTTACAGTTCTGTTGGCTGTCAC
CAGAAAAGAGACCCGCGGCTGAAGATGTGCACAGGCTGCTGACTTACCTGCGGCTGCAGAGCCAGCGGGACTCAGAGGTCGACTTTGAACAGCAGTGGAACGCTCTGAAGCCGAACACAAACAGCAGAGACTCCTCCAACAATGCTGCAT
TCCCAATTCTCGACCACTTTGCCAGGGACCGGCTGGGTCGTGAAATGGAGGAAGTCCTCACCGTGACCGAAACCAGCCAGGGCCTGAGCTTCGAGTATGTCTGGGAGGCCGCTAAGCACGACCACTTTGACGAGCGCAGCCGGGGCCACC
TGGACGAAGGCTTGTCCTACACGAGCATCTTCTATCCGGTTGAAGTTTTTGAGAGTTCGCTTTCAGATCCTGGGCCCGGAAAGCAAGATGACAGCGGCCAGGATGTCCCCCTGAGGGTCCCTGGAGTGGTTCCTGTTTTTGATGCCCACA
ACCTTTCTGTTGGAAGCGACTATTATATCCAGTTAGAAGAAAAAAGTGGTAGTAACTTGGAGCTTGATTACCCACCAGCGCTGCTCACAACCGACATGGATAATCCAGAAAGGACTGGCCCTGAACTGTCCCAGCTCACGGCGCTCAGGA
GCGTTGAACTTGAGGAGTCCAGTACAGATGAGGACTTCTTCCAAAGCAGTACAGACCCCAAAGACTCTAGCTTACCAGGGGACTTACACGTGACCAGTGGCCCCGAGAGCCCTTTCAACAATATATTTAATGATGTGGACAAATCGGAAG
ATTTGCCCAGTCACCAAAAAATATTCGACTTAATGGAATTAAACGGAGTTCAAGCCGACTTTAAACCTGCCACTTTAAGTTCCAGTTTGGATAACCCCAAAGAGTCAGTCATAACAGGCCACTTTGAGAAAGAAAAGCCCCGTAAGATTT
TTGACAGTGAGCCTCTCTGCCTATCAGATAATCTTATGCACCAAGATAATTTTGATCCATTGAATGTTCAAGAATTGTCAGAAAACTTTTTATTTCTTCAAGAGAAAAACTTACTAAAAGGCTCATTGTCCAGCAAAGAACACATAAATG
ATCTTCAGACAGAACTTAAGAATGCTGGTTTTACTGAAGCTATGTTAGAAACGTCATGTAGAAACTCTTTAGATACTGAGCTTCAGTTTGCTGAAAATAAGCCAGGCTTGTCTTTGTTGCAGGAAAACGTAAGCACAAAGGGTGACGATA
CAGATGTCATGCTCACAGGTGACACTTTGAGCACCTCATTGCAGTCTTCCCCGGAAGTGCAGGTACCTCCTACCTCCTTCGAAACAGAAGAAACGCCCCGTCGGGTACCCCCAGACTCACTCCCAACACAGGGAGAAACCCAGCCCACGT
GTTTAGATGTTATTGTCCCGGAGGACTGTCTCCACCAGGACATCAGTCCAGACGCTGTGACTGTCCCGGTTGAAATTCTCTCAACTGATGCCAGAACCCACAGCCTGGATAACAGGTCCCAGGACTCTCCTGGCGAGAGTGAGGAGACCC
TGCGACTCACCGAAAGTGACTCTGTTCTTGCTGATGACATCCTTGCCAGCAGGGTGAGTGTAGGGAGTAGTCTCCCGGAACTGGGACAGGAATTGCACAATAAACCATTTTCGGAAGACCATCACAGTCATCGCCGGCTAGAGAAAAACT
TAGAGGCTGTGGAGACTTTAAATCAGCTCAATTCTAAAGACGCAGCAAAAGAAGCAGGCTTGGTGTCTGCCCTCTCCTCGGACTCAACCAGTCAGGACAGCCTCCTGGAGGACAGCTTGTCAGCACCCTTCCCAGCCTCTGAGCCGTCCC
TGGAAACCCCGGACTCTCTGGAGTCAGTGGATGTCCACGAAGCGCTACTGGACTCTTTAGGATCTCACACTCCCCAGAAACTAGTGCCCCCCGATAAGCCGGCAGACAGTGGCTACGAAACAGAGAACTTGGAGTCTCCCGAGTGGACCT
TGCATCCCGCTCCCGAGGGCACCGCAGACTCAGAACCAGCCACCACGGGCGATGGCGGCCACAGCGGTCTGCCTCCCAACCCGGTCATTGTCATCTCAGATGCCGGCGATGGTCACAGAGGCACAGAAGTGACCCCTGAGACGTTCACAG
CTGGCTCCCAGGGTTCATACCGAGACTCTGCGTACTTCTCAGACAATGACTCTGAGCCCGAGAAAAGGTCTGAGGAGGTCCCGGGAACCTCCCCATCCGCCTTGGTGTTGGTACAGGAGCAGCCCCTACCCGAGCCAGTCCTCCCCGAGC
AAAGTCCTGCTGCCCAGGATAGCTGCCTGGAAGCCAGAAAGAGCCAGCCAGATGAAAGTTGTCTGTCTGCTTTGCACAACTCCAGTGACCTGGAATTAAGAGCCACGCCGGAGCCAGCACAGACTGGTGTTCCCCAGCAGGTGCATCCCA
CGGAAGACGAGGCCAGCAGTCCCTGGAGTGTGCTGAATGCAGAACTTAGCAGCGGCGATGACTTCGAGACACAGGACGATCGCCCCTGCACCCTCGCTTCCACGGGGACCAACACGAACGAACTCCTTGCCTACACCAATTCTGCGCTGG
ACAAGTCCCTGTCCAGCCACTCCGAGGGCCCGAAGTTGAAGGAGCCGGACATCGAAGGGAAGTACCTGGGGAAACTCGGGGTGTCAGGGATGCTCGACCTCTCAGAGGACGGGATGGATGCAGACGAGGAGGACGAAAACAGCGACGACT
CGGACGAGGACCTGCGGGCCTTCAACCTGCATAGCCTCAGCTCCGAGTCGGAGGACGAGACCGAGCACCCCGTGCCCATCATCCTCAGCAACGAGGACGGAAGGCACCTGCGGAGTCTGTTGAAGCCCACAGCGGCCAATGCCCCCGACC
CACTGCCCGAGGACTGGAAGAAGGAAAAGAAGGCAGTCACGTTTTTCGATGATGTCACAGTCTACCTGTTTGACCAGGAGACCCCAACCAAAGAGCTGGGGCCCTGTGGAGGAGAGGCGTGCGGCCCGGACCTGAGCGGCCCAGCCCCAG
CCTCAGGCTCTCCCTACCTGAGCAGGTGCATCAACTCCGAAAGCTCCACCGACGAAGAAGGTGGTGGCTTTGAGTGGGATGATGACTTCTCCCCAGATCCTTTTATGTCAAAGACAACAAGTAACCTGCTCAGCTCCAAGCCTTCTCTCC
AAACATCCAAGTACTTTTCTCCGCCGCCACCGGCCCGGAGCACGGAGCAGAGCTGGCCGCACTCGGCGCCTTACTCCCGGTTCTCCATCTCTCCCGCCAACATTGCCAGCTTTTCCCTCACACACCTGACCGACTCGGACATCGAGCAGG
GCGGAAGCAGCGAAGACGGAGAAAAGGACTAGGTGGCTGCCAACGCGCACGCTCGGGTCCGAGGCTGCTCCCCTGGAGCGGCGCCCCTGCGCCCTCAGCCCGAGCAGCGACATCCACTCGCCATTTGCTGACATGAGATTGGGAGGAAGA
ATCCAGAGGTGAAGAGGGAGACGGCTCTTAGCTGCGTTCAAGGCGGGGCCCTCGGGAGCCCAGGTGCAGAGCGAGGCCGTGTCCAGGAGCCGGCGTCCCTCAGTGCCCCGTGCACCCGCGGCCGCGGCCTCCCAGGCAGTGCTCATGCGC
TGGCCGTCGGGGGAGGCAGGGGCACAGCCTCCATGTGCGCGCGCGTGTGGAGCTGTGTGCACCGCATGTGTGCTTTCCACAGGGGCGTCTCTGCGTCCACGCCTGCACATCCCGGCGCACGTGTGGGCACCACAGAGGACACGTGAGGGG
AATGGTCACCAGTGAGCCATATTTATTATTTCTAGAGAAATCACGAACTGCTTTCTGTAATTGCACTGTGGATAAATGTTCCGAGAGTCTCCATTGTTGTACAGGATCTTCAGTTATTCGAGGGGAATGAGGCAGGTCAAGCCGATGCTA
GCCACTAGTTTGATTTTTTTTCTGTTTTATAGTTTGCGCTGCATGGTACTTGTGAAGCTTAAATATTTTGAGTGTTCTACTGTGTCTAGGATTGTTGGGATTGTACATATGGTACTCTTTCATAAATGATAAATGATTCTGAATGTTAGT
GTTTTATGTTCATATAGGAAATATTTTCATTGAGTCCAAAATACCACTGTTTTGTTGATGGACTTGAATGCATTTTTGTCTCTTCTTGATGAAGCGGCTTTGCCGCAGCAAATGAGGCTTCTCTCTGAGGAGCTGAGAGGTCTTGCAGCC
TCTCCTTGTCATTCTCCCACCCCACATCCCATTTTTTAAAGCCCTTTTGGTAAAAACCAACAGGTTGTGGCCGCAGACCTCAGATGGACCCGGCCCATCCCTGGGGACGTGCTGGCGTGGCAGGTCCAGAGAGCTGCACCCTGCACGGGG
CACCGCACCGCTTCCCTCCGCGCAGCTCTTCTGCCTGGTTTTCGGAGGCCAGGCTGCTGGGAAGCTTCCGTGTTCCTGTCAGTCCTTCCTTCAAGAAGCCGGGGAACTCAGGCAGACTCATCTCCGCAGAGCATACCAGCCGTGGGGGAC
CGTTCGACTTGATGATGTGTGCACACTTCAGGTGGTGGGGACTTGAGCTTTAAAAAAACCTCCACAGCCGAATCTTCTCCTCCGAGCCACTCCACGTCACGTCCAGCTGGGCCTGGCCAGTCTGTGGTTATCCATGTGGGATGAGATAAC
ACCACATCCTGCAGCTGTGAAGGGGGATGGACAAGGGACGACGGCCGACGGCAGAGCATCAGCAGCCGACACATAGTTCGGGTCGGGGCCTTGGGTGGTCCTGCATGGCCCGGGACTCATCTCACGGACCCTCCGTTCTGCATTAAGCCC
CAGGTTCTCTTCTGGCTTTGAAAGGGCCCGAGTGCTCCCAGTGTAGCTTCGTCACATCGTCACGAGCCCCTGTGGTCATGGGCGACCTCACACCTCCCTCCCTGAGTTCTGCTCTGACATAAGGAAGTCCTCGGTGGCTGGTGCAGCGCG
GCTGTGCTGTGCTGGGGAGGCAGCCGTTCCTTCGGGGGTCCTTGGGCCTGCAGTCCCCTCATACTCACCCTTCACCCAACATATTTTCCGGTGCTGATATGTTTCCAGACTCCAGCGCAACCTGGGGTGCTCTCCAGACCCGTGCAGGGG
CCGCCTGGGGTACACGGAAGGAAGTTGAGTCCTAGTGCAAAATGCAGGCGGACGTTGCCAGAGAGTGCGCAGCAAATGACCTTCATTGCCAGTTCCACCCTACTCCTCTCATTTTTTATACTAAGCAATAACTTTCCAAAGCAAGAAGTT
CAGGATGGAGAGAGTCCCCTCCTGTGTAGGCATGGGGTGGATGCGGTGCCCACCTGGGCTATGTGGGGAGCACCACTGTCTCGGGATGCGCGAATTTTTTTTTTTTTTTTAATTAACAGGGCATTAGAAGATGATTTTGCCAAAATTGTC
ATGACTCTGAATTCTTGCTGTGGGGACTTCCTGAGTTTTCTCAGTTTTTACATCTAAGATTAGTCTTGGCTGAAGAGAAATGAGACGTGATTATACTACTTTTTCAATTGCAGGTTTAAGGAGTTCAGATTTAATGACCAAAGTCATACA
GATCATGGAATCTGTCGTCGTCTTATACAGTGTCAGCCTCGAGTACATTTATTAACCTTTTGGGGCTGTCAGTTTTCCACTAGGATTAAGATTTTGGCCGGGCGCGGTGGCTCACGCCTGCAATCCCAACACATTGGGGGGTCGAGGCGG
ACGGATCACTTTGAGCCCAGGAGTTCAAGACCAGCCTGGGCAACATGGCGAAACCTCGTCTCTACTAAAAATACAAAATATATATATATATATATATACTAGCTGGGGCACATAGTGGTGTGCACCTGTAGTCCCAGCTGCTTGGGAGGC
TGAGGTGGGAGGATGGCTAGAGCCCAGGAGATGGGTGTTGCAGTGAGCTGAGACCATGCCACTGTACTCTAGCCTGGGTAACAGCCAGACCCTGTCTCAAAAAAAAAAACAATTTTTTTCATAACATAATTCCCATTTTTATTTATTTTG
AGTCACTCATAATTAATTGCCAAAAAAGCATTTTATACATTGAGTTGGGGGGTAGTGGATCTTAGTGTGGTGTTGCATGGAGGGGCGAGATTTTATATTTATAATCAACACGTGGGTTAACATGTTTTTTTGAAATCCAAGCAATACACA
GGAAATTTAAGTAGAATAAAAATTGCAGCCCATTTTTGAAATGTCAGCATGTGCTGTGTTCAGTTCAGGTTTTTGTTGTTTGTTTTGTTATTTTTTAACTAATAAGTTGGTTATCAGTGGTGGGTTTTCAAAATGTACTTGTTCTAATAA
GTTGTACAATGAACTAAATCAGTGGCATTCTCTAGATAATGTGGGGGAAGGTTAGAATATTTTCTGGCCTTCTATGGGGTAGCAACCCAGAATCAATCTGAATTAGTCCTGTTTTGGTGGAGTTTGTACATTTTAAATCCTATAACAAAA
ATAATCTAGTTTTCATTTCCTTACTAGCTAGATGCGAATTTGTCTTTTTGAATGACCCTGTCAATAAGCCAGAAAGGGCAACCCAGAAAAAGTGCTCCCCACATCCTTCTGAGACTTGGCCTGTGTGTGTGGACGAGAAGCCATTCACCG
TAAGGGTGCAGAAAGCTCGACCAAGCCGAATTGCAAACAACGTTCGTTCTATTTTTAAATGTACAGGTTCGATCGTTTCTATAGAAATGGGTTTATCTAAGAAAAGTCTTGGTTTGTCTTGCTGCTGTAAAAGGCCTTTCCAAACCCCTC
CTTTTATTCCTGTTTCCCGAAATAAGGTATTTGTAGAGTTAAGGACCTACTGCATGCCTGTCCCCAGGGCCCCGGTGGAAGGAAGGCAGCGCCTGCTCTTCCTTAACTCAGCCCATCATCTGAAAATTCAGAAGTGAACCAAGGGTTAGA
CGCCAGAGGTTGGGCTTCTGTTAGAGTGGCTTCAAAACATGAGCCTTATGGGAAGTAGCCTTAAAAAAAGAATGGGTATACGCAGTGACTTCCGATGGAAATCTCCAAAACAATATTCCTAAGTAGCAATGGGGTTGGCTCAAGTCTTTA
TTAACAAAGAACATTCTCTTTCATCTATAAAGAAATTCTTAAAGATGCATTGACAGTGTTGAATTACCAACAGCCTGTGAAGATCAGTTTGACCGGTGTGGACACGTGCTGGTTAAGCACTCAGGCCTACGTGGGCCGAGCGGGATCTTG
ATCATGGGGCTGGTGTATGGATCCACCGTCGGATTCCGTCTGCAGAGGAGGACGTAGGGGGCCGTCACACCCACCAGGCCTCCCTGCTGTGCTTTAACACAGGCAGAAGAGGTTCATGGCAATATAATAGTCAATGAACTTTCAGTTTAA
ATTGTGTACATTTTTAAATTGTAAGATTTTTACTGTATATTGATGCATAGTGTGATTCAATAAATTGCTTGTAATTTAAAAACTATTTAATATTCAAAATAAATATAGTTATATATTTATAAA

N-Truncated Transcript (5UTR-3CDS) Sequences

>TMEM230_LMTK2_ENST00000492419_ENST00000297293_5086833_97820039 length=7655nt 
 Breakpoint=0nt
GTCTCTGGGTGTGACACTTTGGGAGCTTTTTGACAATGCCGCACAGCCGTATTCAAACCTTTCCAACTTAGATGTCCTCAACCAAGTCATTAGAGAGAGAGACACAAAACTCCCGAAGCCCCAGCTGGAGCAGCCCTACTCTGATAGATG
GTATGAAGTCTTACAGTTCTGTTGGCTGTCACCAGAAAAGAGACCCGCGGCTGAAGATGTGCACAGGCTGCTGACTTACCTGCGGCTGCAGAGCCAGCGGGACTCAGAGGTCGACTTTGAACAGCAGTGGAACGCTCTGAAGCCGAACAC
AAACAGCAGAGACTCCTCCAACAATGCTGCATTCCCAATTCTCGACCACTTTGCCAGGGACCGGCTGGGTCGTGAAATGGAGGAAGTCCTCACCGTGACCGAAACCAGCCAGGGCCTGAGCTTCGAGTATGTCTGGGAGGCCGCTAAGCA
CGACCACTTTGACGAGCGCAGCCGGGGCCACCTGGACGAAGGCTTGTCCTACACGAGCATCTTCTATCCGGTTGAAGTTTTTGAGAGTTCGCTTTCAGATCCTGGGCCCGGAAAGCAAGATGACAGCGGCCAGGATGTCCCCCTGAGGGT
CCCTGGAGTGGTTCCTGTTTTTGATGCCCACAACCTTTCTGTTGGAAGCGACTATTATATCCAGTTAGAAGAAAAAAGTGGTAGTAACTTGGAGCTTGATTACCCACCAGCGCTGCTCACAACCGACATGGATAATCCAGAAAGGACTGG
CCCTGAACTGTCCCAGCTCACGGCGCTCAGGAGCGTTGAACTTGAGGAGTCCAGTACAGATGAGGACTTCTTCCAAAGCAGTACAGACCCCAAAGACTCTAGCTTACCAGGGGACTTACACGTGACCAGTGGCCCCGAGAGCCCTTTCAA
CAATATATTTAATGATGTGGACAAATCGGAAGATTTGCCCAGTCACCAAAAAATATTCGACTTAATGGAATTAAACGGAGTTCAAGCCGACTTTAAACCTGCCACTTTAAGTTCCAGTTTGGATAACCCCAAAGAGTCAGTCATAACAGG
CCACTTTGAGAAAGAAAAGCCCCGTAAGATTTTTGACAGTGAGCCTCTCTGCCTATCAGATAATCTTATGCACCAAGATAATTTTGATCCATTGAATGTTCAAGAATTGTCAGAAAACTTTTTATTTCTTCAAGAGAAAAACTTACTAAA
AGGCTCATTGTCCAGCAAAGAACACATAAATGATCTTCAGACAGAACTTAAGAATGCTGGTTTTACTGAAGCTATGTTAGAAACGTCATGTAGAAACTCTTTAGATACTGAGCTTCAGTTTGCTGAAAATAAGCCAGGCTTGTCTTTGTT
GCAGGAAAACGTAAGCACAAAGGGTGACGATACAGATGTCATGCTCACAGGTGACACTTTGAGCACCTCATTGCAGTCTTCCCCGGAAGTGCAGGTACCTCCTACCTCCTTCGAAACAGAAGAAACGCCCCGTCGGGTACCCCCAGACTC
ACTCCCAACACAGGGAGAAACCCAGCCCACGTGTTTAGATGTTATTGTCCCGGAGGACTGTCTCCACCAGGACATCAGTCCAGACGCTGTGACTGTCCCGGTTGAAATTCTCTCAACTGATGCCAGAACCCACAGCCTGGATAACAGGTC
CCAGGACTCTCCTGGCGAGAGTGAGGAGACCCTGCGACTCACCGAAAGTGACTCTGTTCTTGCTGATGACATCCTTGCCAGCAGGGTGAGTGTAGGGAGTAGTCTCCCGGAACTGGGACAGGAATTGCACAATAAACCATTTTCGGAAGA
CCATCACAGTCATCGCCGGCTAGAGAAAAACTTAGAGGCTGTGGAGACTTTAAATCAGCTCAATTCTAAAGACGCAGCAAAAGAAGCAGGCTTGGTGTCTGCCCTCTCCTCGGACTCAACCAGTCAGGACAGCCTCCTGGAGGACAGCTT
GTCAGCACCCTTCCCAGCCTCTGAGCCGTCCCTGGAAACCCCGGACTCTCTGGAGTCAGTGGATGTCCACGAAGCGCTACTGGACTCTTTAGGATCTCACACTCCCCAGAAACTAGTGCCCCCCGATAAGCCGGCAGACAGTGGCTACGA
AACAGAGAACTTGGAGTCTCCCGAGTGGACCTTGCATCCCGCTCCCGAGGGCACCGCAGACTCAGAACCAGCCACCACGGGCGATGGCGGCCACAGCGGTCTGCCTCCCAACCCGGTCATTGTCATCTCAGATGCCGGCGATGGTCACAG
AGGCACAGAAGTGACCCCTGAGACGTTCACAGCTGGCTCCCAGGGTTCATACCGAGACTCTGCGTACTTCTCAGACAATGACTCTGAGCCCGAGAAAAGGTCTGAGGAGGTCCCGGGAACCTCCCCATCCGCCTTGGTGTTGGTACAGGA
GCAGCCCCTACCCGAGCCAGTCCTCCCCGAGCAAAGTCCTGCTGCCCAGGATAGCTGCCTGGAAGCCAGAAAGAGCCAGCCAGATGAAAGTTGTCTGTCTGCTTTGCACAACTCCAGTGACCTGGAATTAAGAGCCACGCCGGAGCCAGC
ACAGACTGGTGTTCCCCAGCAGGTGCATCCCACGGAAGACGAGGCCAGCAGTCCCTGGAGTGTGCTGAATGCAGAACTTAGCAGCGGCGATGACTTCGAGACACAGGACGATCGCCCCTGCACCCTCGCTTCCACGGGGACCAACACGAA
CGAACTCCTTGCCTACACCAATTCTGCGCTGGACAAGTCCCTGTCCAGCCACTCCGAGGGCCCGAAGTTGAAGGAGCCGGACATCGAAGGGAAGTACCTGGGGAAACTCGGGGTGTCAGGGATGCTCGACCTCTCAGAGGACGGGATGGA
TGCAGACGAGGAGGACGAAAACAGCGACGACTCGGACGAGGACCTGCGGGCCTTCAACCTGCATAGCCTCAGCTCCGAGTCGGAGGACGAGACCGAGCACCCCGTGCCCATCATCCTCAGCAACGAGGACGGAAGGCACCTGCGGAGTCT
GTTGAAGCCCACAGCGGCCAATGCCCCCGACCCACTGCCCGAGGACTGGAAGAAGGAAAAGAAGGCAGTCACGTTTTTCGATGATGTCACAGTCTACCTGTTTGACCAGGAGACCCCAACCAAAGAGCTGGGGCCCTGTGGAGGAGAGGC
GTGCGGCCCGGACCTGAGCGGCCCAGCCCCAGCCTCAGGCTCTCCCTACCTGAGCAGGTGCATCAACTCCGAAAGCTCCACCGACGAAGAAGGTGGTGGCTTTGAGTGGGATGATGACTTCTCCCCAGATCCTTTTATGTCAAAGACAAC
AAGTAACCTGCTCAGCTCCAAGCCTTCTCTCCAAACATCCAAGTACTTTTCTCCGCCGCCACCGGCCCGGAGCACGGAGCAGAGCTGGCCGCACTCGGCGCCTTACTCCCGGTTCTCCATCTCTCCCGCCAACATTGCCAGCTTTTCCCT
CACACACCTGACCGACTCGGACATCGAGCAGGGCGGAAGCAGCGAAGACGGAGAAAAGGACTAGGTGGCTGCCAACGCGCACGCTCGGGTCCGAGGCTGCTCCCCTGGAGCGGCGCCCCTGCGCCCTCAGCCCGAGCAGCGACATCCACT
CGCCATTTGCTGACATGAGATTGGGAGGAAGAATCCAGAGGTGAAGAGGGAGACGGCTCTTAGCTGCGTTCAAGGCGGGGCCCTCGGGAGCCCAGGTGCAGAGCGAGGCCGTGTCCAGGAGCCGGCGTCCCTCAGTGCCCCGTGCACCCG
CGGCCGCGGCCTCCCAGGCAGTGCTCATGCGCTGGCCGTCGGGGGAGGCAGGGGCACAGCCTCCATGTGCGCGCGCGTGTGGAGCTGTGTGCACCGCATGTGTGCTTTCCACAGGGGCGTCTCTGCGTCCACGCCTGCACATCCCGGCGC
ACGTGTGGGCACCACAGAGGACACGTGAGGGGAATGGTCACCAGTGAGCCATATTTATTATTTCTAGAGAAATCACGAACTGCTTTCTGTAATTGCACTGTGGATAAATGTTCCGAGAGTCTCCATTGTTGTACAGGATCTTCAGTTATT
CGAGGGGAATGAGGCAGGTCAAGCCGATGCTAGCCACTAGTTTGATTTTTTTTCTGTTTTATAGTTTGCGCTGCATGGTACTTGTGAAGCTTAAATATTTTGAGTGTTCTACTGTGTCTAGGATTGTTGGGATTGTACATATGGTACTCT
TTCATAAATGATAAATGATTCTGAATGTTAGTGTTTTATGTTCATATAGGAAATATTTTCATTGAGTCCAAAATACCACTGTTTTGTTGATGGACTTGAATGCATTTTTGTCTCTTCTTGATGAAGCGGCTTTGCCGCAGCAAATGAGGC
TTCTCTCTGAGGAGCTGAGAGGTCTTGCAGCCTCTCCTTGTCATTCTCCCACCCCACATCCCATTTTTTAAAGCCCTTTTGGTAAAAACCAACAGGTTGTGGCCGCAGACCTCAGATGGACCCGGCCCATCCCTGGGGACGTGCTGGCGT
GGCAGGTCCAGAGAGCTGCACCCTGCACGGGGCACCGCACCGCTTCCCTCCGCGCAGCTCTTCTGCCTGGTTTTCGGAGGCCAGGCTGCTGGGAAGCTTCCGTGTTCCTGTCAGTCCTTCCTTCAAGAAGCCGGGGAACTCAGGCAGACT
CATCTCCGCAGAGCATACCAGCCGTGGGGGACCGTTCGACTTGATGATGTGTGCACACTTCAGGTGGTGGGGACTTGAGCTTTAAAAAAACCTCCACAGCCGAATCTTCTCCTCCGAGCCACTCCACGTCACGTCCAGCTGGGCCTGGCC
AGTCTGTGGTTATCCATGTGGGATGAGATAACACCACATCCTGCAGCTGTGAAGGGGGATGGACAAGGGACGACGGCCGACGGCAGAGCATCAGCAGCCGACACATAGTTCGGGTCGGGGCCTTGGGTGGTCCTGCATGGCCCGGGACTC
ATCTCACGGACCCTCCGTTCTGCATTAAGCCCCAGGTTCTCTTCTGGCTTTGAAAGGGCCCGAGTGCTCCCAGTGTAGCTTCGTCACATCGTCACGAGCCCCTGTGGTCATGGGCGACCTCACACCTCCCTCCCTGAGTTCTGCTCTGAC
ATAAGGAAGTCCTCGGTGGCTGGTGCAGCGCGGCTGTGCTGTGCTGGGGAGGCAGCCGTTCCTTCGGGGGTCCTTGGGCCTGCAGTCCCCTCATACTCACCCTTCACCCAACATATTTTCCGGTGCTGATATGTTTCCAGACTCCAGCGC
AACCTGGGGTGCTCTCCAGACCCGTGCAGGGGCCGCCTGGGGTACACGGAAGGAAGTTGAGTCCTAGTGCAAAATGCAGGCGGACGTTGCCAGAGAGTGCGCAGCAAATGACCTTCATTGCCAGTTCCACCCTACTCCTCTCATTTTTTA
TACTAAGCAATAACTTTCCAAAGCAAGAAGTTCAGGATGGAGAGAGTCCCCTCCTGTGTAGGCATGGGGTGGATGCGGTGCCCACCTGGGCTATGTGGGGAGCACCACTGTCTCGGGATGCGCGAATTTTTTTTTTTTTTTTAATTAACA
GGGCATTAGAAGATGATTTTGCCAAAATTGTCATGACTCTGAATTCTTGCTGTGGGGACTTCCTGAGTTTTCTCAGTTTTTACATCTAAGATTAGTCTTGGCTGAAGAGAAATGAGACGTGATTATACTACTTTTTCAATTGCAGGTTTA
AGGAGTTCAGATTTAATGACCAAAGTCATACAGATCATGGAATCTGTCGTCGTCTTATACAGTGTCAGCCTCGAGTACATTTATTAACCTTTTGGGGCTGTCAGTTTTCCACTAGGATTAAGATTTTGGCCGGGCGCGGTGGCTCACGCC
TGCAATCCCAACACATTGGGGGGTCGAGGCGGACGGATCACTTTGAGCCCAGGAGTTCAAGACCAGCCTGGGCAACATGGCGAAACCTCGTCTCTACTAAAAATACAAAATATATATATATATATATATACTAGCTGGGGCACATAGTGG
TGTGCACCTGTAGTCCCAGCTGCTTGGGAGGCTGAGGTGGGAGGATGGCTAGAGCCCAGGAGATGGGTGTTGCAGTGAGCTGAGACCATGCCACTGTACTCTAGCCTGGGTAACAGCCAGACCCTGTCTCAAAAAAAAAAACAATTTTTT
TCATAACATAATTCCCATTTTTATTTATTTTGAGTCACTCATAATTAATTGCCAAAAAAGCATTTTATACATTGAGTTGGGGGGTAGTGGATCTTAGTGTGGTGTTGCATGGAGGGGCGAGATTTTATATTTATAATCAACACGTGGGTT
AACATGTTTTTTTGAAATCCAAGCAATACACAGGAAATTTAAGTAGAATAAAAATTGCAGCCCATTTTTGAAATGTCAGCATGTGCTGTGTTCAGTTCAGGTTTTTGTTGTTTGTTTTGTTATTTTTTAACTAATAAGTTGGTTATCAGT
GGTGGGTTTTCAAAATGTACTTGTTCTAATAAGTTGTACAATGAACTAAATCAGTGGCATTCTCTAGATAATGTGGGGGAAGGTTAGAATATTTTCTGGCCTTCTATGGGGTAGCAACCCAGAATCAATCTGAATTAGTCCTGTTTTGGT
GGAGTTTGTACATTTTAAATCCTATAACAAAAATAATCTAGTTTTCATTTCCTTACTAGCTAGATGCGAATTTGTCTTTTTGAATGACCCTGTCAATAAGCCAGAAAGGGCAACCCAGAAAAAGTGCTCCCCACATCCTTCTGAGACTTG
GCCTGTGTGTGTGGACGAGAAGCCATTCACCGTAAGGGTGCAGAAAGCTCGACCAAGCCGAATTGCAAACAACGTTCGTTCTATTTTTAAATGTACAGGTTCGATCGTTTCTATAGAAATGGGTTTATCTAAGAAAAGTCTTGGTTTGTC
TTGCTGCTGTAAAAGGCCTTTCCAAACCCCTCCTTTTATTCCTGTTTCCCGAAATAAGGTATTTGTAGAGTTAAGGACCTACTGCATGCCTGTCCCCAGGGCCCCGGTGGAAGGAAGGCAGCGCCTGCTCTTCCTTAACTCAGCCCATCA
TCTGAAAATTCAGAAGTGAACCAAGGGTTAGACGCCAGAGGTTGGGCTTCTGTTAGAGTGGCTTCAAAACATGAGCCTTATGGGAAGTAGCCTTAAAAAAAGAATGGGTATACGCAGTGACTTCCGATGGAAATCTCCAAAACAATATTC
CTAAGTAGCAATGGGGTTGGCTCAAGTCTTTATTAACAAAGAACATTCTCTTTCATCTATAAAGAAATTCTTAAAGATGCATTGACAGTGTTGAATTACCAACAGCCTGTGAAGATCAGTTTGACCGGTGTGGACACGTGCTGGTTAAGC
ACTCAGGCCTACGTGGGCCGAGCGGGATCTTGATCATGGGGCTGGTGTATGGATCCACCGTCGGATTCCGTCTGCAGAGGAGGACGTAGGGGGCCGTCACACCCACCAGGCCTCCCTGCTGTGCTTTAACACAGGCAGAAGAGGTTCATG
GCAATATAATAGTCAATGAACTTTCAGTTTAAATTGTGTACATTTTTAAATTGTAAGATTTTTACTGTATATTGATGCATAGTGTGATTCAATAAATTGCTTGTAATTTAAAAACTATTTAATATTCAAAATAAATATAGTTATATATTT
ATAAA

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for TMEM230_LMTK2

In-frame Fusion Protein Sequences.

>TMEM230_LMTK2_ENST00000379283_ENST00000297293_5086833_97820039 length=203nt
MRPCAAGWGGLRCAEALVSAMIRQERSTSYQEAVRPALPSSKPCLLTSPAVLVKLLSSSASTSRPPNLGHLWQPSSSVPLHRAASLAKVRQFQLSEELVQVVENSELADEQDKETVRVQGPGILPGTDPTGSSDTGSITSCPIIHSNTNS
PYCHSEPASTTSSSNTACCPGSSPAASSTPAAGSVHPAPANFKSASTTSYSPC

N-Truncated Protein (5UTR-3CDS) Sequences

>TMEM230_LMTK2_ENST00000492419_ENST00000297293_5086833_97820039 length=371nt
MLALQMNEEQYQKDGQLIECRCCYGEFPFEELTQCADAHLFCKECLIRYAQEAVFGSGKLELSCMEGSCTCSFPTSELEKVLPQTILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSDVKRFSCPNPHCRKETCRKCQGLWKEHNG
LTCEELAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRCGAQMCYLCRVSINGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEKLIEEIQKEAEEEQKRKNGENTFKRIGPPLEKPVEKVQRVEALPRPVPQNLPQP
QMPPYAFAHPPFPLPPVRPVFNNFPLNMGPIPAPYVPPLPNVRVNYDFGPIHMPLEHNLPMHFGPQPRHRF

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for TMEM230_LMTK2

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for TMEM230_LMTK2

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		LUAD	TCGA-62-A46U-01A	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+
ChimerDB		LUAD	TCGA-62-A46U	TMEM230	chr20	5086833	-	LMTK2	chr7	5086833	+

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for TMEM230_LMTK2

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status