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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:ANKRD11_CES5A (FusionGDB2 ID:HG29123TG221223)

Fusion Gene Summary for ANKRD11_CES5A

Fusion gene summary

Fusion gene information	Fusion gene name: ANKRD11_CES5A
	Fusion gene ID: hg29123tg221223
		Hgene	Tgene
	Gene symbol	ANKRD11	CES5A
	Gene ID	29123	221223
	Gene name	ankyrin repeat domain containing 11	carboxylesterase 5A
	Synonyms	ANCO-1\|ANCO1\|LZ16\|T13	CAUXIN\|CES4C1\|CES5\|CES7\|HEL126
	Cytomap	16q24.3	16q12.2
	Type of gene	protein-coding	protein-coding
	Description	ankyrin repeat domain-containing protein 11ankyrin repeat domain 11ankyrin repeat-containing cofactor 1ankyrin repeats containing cofactor 1nasopharyngeal carcinoma susceptibility protein	carboxylesterase 5Acarboxylesterase 5carboxylesterase 7carboxylesterase-like urinary excreted protein homologepididymis luminal protein 126
	Modification date	20240407	20240305
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000301030, ENST00000378330, ENST00000563291, ENST00000567736,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 77 X 71 X 40=218680	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 2 X 5 X 2=20
	# samples	144	4
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(144/21868010)=-7.24660865875727 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(4/2010)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ANKRD11 [Title/Abstract] AND CES5A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ANKRD11(89484691)-CES5A(55983814), # samples:1

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Fusion Gene Breakpoints for ANKRD11_CES5A

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ANKRD11	chr16	89484691	CES5A	chr16	55983814
ANKRD11	chr16	89484692	CES5A	chr16	55983814

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for ANKRD11_CES5A

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
ANKRD11-CES5A	Promoter / Enhancer Hijacking M6		Promoter swap alters carboxylesterase 5A expression, modifying lipid ester hydrolysis and prodrug metabolic activation.		Esterase modulators; standard chemotherapy		Epithelial carcinomas

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
ANKRD11-CES5A	Promoter / Enhancer Hijacking M6		Promoter swap alters carboxylesterase 5A expression, modifying lipid ester hydrolysis and prodrug metabolic activation.	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 28698656; Title: Gene-gene and gene-environment interactions influence platinum-based chemotherapy response and toxicity in non-small cell lung cancer patients.	Esterase modulators; standard chemotherapy	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 28698656; Title: Gene-gene and gene-environment interactions influence platinum-based chemotherapy response and toxicity in non-small cell lung cancer patients.	Epithelial carcinomas	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 28698656; Title: Gene-gene and gene-environment interactions influence platinum-based chemotherapy response and toxicity in non-small cell lung cancer patients.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

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Fusion Genomic Features for ANKRD11_CES5A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ANKRD11	chr16	89484691	-	CES5A	chr16	55983814	-	1.53e-07	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ANKRD11	chr16	89484691	-	CES5A	chr16	55983814	-	1.53e-07	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for ANKRD11_CES5A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000301030	ENST00000521992	ANKRD11	chr16	89484691	-	CES5A	chr16	55983814	-
5UTR-3CDS	ENST00000378330	ENST00000521992	ANKRD11	chr16	89484691	-	CES5A	chr16	55983814	-

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000301030	ENST00000521992	ANKRD11	chr16	89484691	CES5A	chr16	55983814	0	516
ENST00000378330	ENST00000521992	ANKRD11	chr16	89484691	CES5A	chr16	55983814	0	516

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000301030	ENST00000521992	ANKRD11	chr16	89484691	CES5A	chr16	55983814	0.00e+00	1.78e-04
ENST00000378330	ENST00000521992	ANKRD11	chr16	89484691	CES5A	chr16	55983814	0.00e+00	1.78e-04

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for ANKRD11_CES5A

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for ANKRD11_CES5A

In-frame Fusion Transcript Sequences.

N-Truncated Transcript (5UTR-3CDS) Sequences

>ANKRD11_CES5A_ENST00000301030_ENST00000521992_89484691_55983814 length=2070nt 
 Breakpoint=0nt
GAGTTTAGGATAAGAAGGGGAATGTGGAGATTGTGCCTGGTTTACTATTTTTATCCAGCCTCCTCAACTTTGTATGTATTGAGGATTGATGTCTTAAACTACACTTCCAAAGATGAGGGGCCTTCTGCTGAAGGGCCACAGAGGAACACC
AGGCTGGGATGGATTCAGGGCAAGCAAGTCACTGTGCTGGGAAGCCCTGTGCCTGTGAACGTGTTCCTCGGAGTCCCCTTTGCTGCTCCCCCGCTGGGATCCCTGCGATTTACGAACCCGCAGCCTGCATCGCCCTGGGATAACTTGCGA
GAAGCCACCTCCTACCCTAATTTGTGCCTCCAGAACTCAGAGTGGCTGCTCTTAGATCAACATATGCTCAAGGTGCATTACCCGAAATTCGGAGTGTCAGAAGACTGCCTCTACCTGAACATCTATGCGCCTGCCCACGCCGATACAGGC
TCCAAGCTCCCCGTCTTGGTGTGGTTCCCAGGAGGTGCCTTCAAGACTGGCTCAGCCTCCATCTTTGATGGGTCCGCCCTGGCTGCCTATGAGGACGTGCTGGTTGTGGTCGTCCAGTACCGGCTAGGAATATTTGGTTTCTTCACCACA
TGGGATCAGCATGCTCCGGGGAACTGGGCCTTCAAGGACCAGGTGGCTGCTCTGTCCTGGGTCCAGAAGAACATCGAGTTCTTCGGTGGGGACCCCAGCTCTGTGACCATCTTTGGCGAGTCCGCGGGAGCCATAAGTGTTTCTAGTCTT
ATACTGTCTCCCATGGCCAAAGGCTTATTCCACAAAGCCATCATGGAGAGTGGGGTGGCCATCATCCCTTACCTGGAGGCCCATGATTATGAGAAGAGTGAGGACCTGCAGGTGGTTGCACATTTCTGTGGTAACAATGCGTCAGACTCT
GAGGCCCTGCTGAGGTGCCTGAGGACAAAACCCTCCAAGGAGCTGCTGACCCTCAGCCAGAAAACAAAGTCTTTCACTCGAGTGGTTGATGGTGCTTTCTTTCCTAATGAGCCTCTAGATCTATTGTCTCAGAAAGCATTTAAAGCAATT
CCTTCCATCATCGGAGTCAATAACCACGAGTGTGGCTTCCTGCTGCCTATGAAGGAGGCTCCTGAGATCCTCAGTGGCTCCAACAAGTCCCTTGCCCTCCATCTGATACAAAACATCCTGCACATCCCGCCTCAGTATTTGCACCTTGTG
GCTAATGAATACTTCCATGACAAGCACTCCCTGACTGAAATCCGAGACAGTCTTCTGGACTTGCTTGGAGATGTGTTCTTTGTGGTCCCTGCACTGATCACAGCTCGATATCACAGAGATGCTGGTGCACCTGTCTACTTCTATGAGTTT
CGGCACCGGCCTCAGTGCTTTGAAGACACGAAGCCAGCTTTTGTCAAAGCCGACCACGCTGATGAAGTCCGCTTTGTGTTCGGTGGTGCCTTCCTGAAGGGGGACATTGTTATGTTCGAAGGAGCCACGGAGGAGGAGAAGTTACTGAGC
CGGAAGATGATGAAATACTGGGCTACCTTTGCTCGAACCGGGAATCCTAATGGGAACGACCTGTCTCTGTGGCCAGCTTATAATCTGACTGAGCAGTACCTCCAGCTGGACTTGAACATGAGCCTCGGACAGAGACTCAAAGAACCGCGG
GTGGATTTTTGGACCAGCACCATCCCCCTGATCCTGTCTGCCTCCGACATGCTCCACAGTCCTCTTTCTTCCTTAACTTTCCTCTCTCTCCTCCAGCCTTTCTTTTTCTTTTGTGCTCCTTGAGAAGTTATCTTTCTGTGATTTTGGTTT
CCCTTCTCCTCCCATAATTTCTCCCGCAATCATTAGCTTCTTTCTGAGCTCAGCTGCTTTCTATGGGGATCCTTGCAAAACAAGCTGCTTTCGCTGATATTTTATGGACTTAGGAATGATCCTTACAGAATTCTTTTCAACATCAAAAAG
TGCAATTTGTCTTGGAAGGCAACAAGATTTCTTCAATAAATTTGGAAGAGGGCTGGCCTATTAGTTGTCATAATAATGGTTTTGTAACTCATATGAAATAAAATCAGAATGTAAAATAGG

>ANKRD11_CES5A_ENST00000378330_ENST00000521992_89484691_55983814 length=2070nt 
 Breakpoint=0nt
GAGTTTAGGATAAGAAGGGGAATGTGGAGATTGTGCCTGGTTTACTATTTTTATCCAGCCTCCTCAACTTTGTATGTATTGAGGATTGATGTCTTAAACTACACTTCCAAAGATGAGGGGCCTTCTGCTGAAGGGCCACAGAGGAACACC
AGGCTGGGATGGATTCAGGGCAAGCAAGTCACTGTGCTGGGAAGCCCTGTGCCTGTGAACGTGTTCCTCGGAGTCCCCTTTGCTGCTCCCCCGCTGGGATCCCTGCGATTTACGAACCCGCAGCCTGCATCGCCCTGGGATAACTTGCGA
GAAGCCACCTCCTACCCTAATTTGTGCCTCCAGAACTCAGAGTGGCTGCTCTTAGATCAACATATGCTCAAGGTGCATTACCCGAAATTCGGAGTGTCAGAAGACTGCCTCTACCTGAACATCTATGCGCCTGCCCACGCCGATACAGGC
TCCAAGCTCCCCGTCTTGGTGTGGTTCCCAGGAGGTGCCTTCAAGACTGGCTCAGCCTCCATCTTTGATGGGTCCGCCCTGGCTGCCTATGAGGACGTGCTGGTTGTGGTCGTCCAGTACCGGCTAGGAATATTTGGTTTCTTCACCACA
TGGGATCAGCATGCTCCGGGGAACTGGGCCTTCAAGGACCAGGTGGCTGCTCTGTCCTGGGTCCAGAAGAACATCGAGTTCTTCGGTGGGGACCCCAGCTCTGTGACCATCTTTGGCGAGTCCGCGGGAGCCATAAGTGTTTCTAGTCTT
ATACTGTCTCCCATGGCCAAAGGCTTATTCCACAAAGCCATCATGGAGAGTGGGGTGGCCATCATCCCTTACCTGGAGGCCCATGATTATGAGAAGAGTGAGGACCTGCAGGTGGTTGCACATTTCTGTGGTAACAATGCGTCAGACTCT
GAGGCCCTGCTGAGGTGCCTGAGGACAAAACCCTCCAAGGAGCTGCTGACCCTCAGCCAGAAAACAAAGTCTTTCACTCGAGTGGTTGATGGTGCTTTCTTTCCTAATGAGCCTCTAGATCTATTGTCTCAGAAAGCATTTAAAGCAATT
CCTTCCATCATCGGAGTCAATAACCACGAGTGTGGCTTCCTGCTGCCTATGAAGGAGGCTCCTGAGATCCTCAGTGGCTCCAACAAGTCCCTTGCCCTCCATCTGATACAAAACATCCTGCACATCCCGCCTCAGTATTTGCACCTTGTG
GCTAATGAATACTTCCATGACAAGCACTCCCTGACTGAAATCCGAGACAGTCTTCTGGACTTGCTTGGAGATGTGTTCTTTGTGGTCCCTGCACTGATCACAGCTCGATATCACAGAGATGCTGGTGCACCTGTCTACTTCTATGAGTTT
CGGCACCGGCCTCAGTGCTTTGAAGACACGAAGCCAGCTTTTGTCAAAGCCGACCACGCTGATGAAGTCCGCTTTGTGTTCGGTGGTGCCTTCCTGAAGGGGGACATTGTTATGTTCGAAGGAGCCACGGAGGAGGAGAAGTTACTGAGC
CGGAAGATGATGAAATACTGGGCTACCTTTGCTCGAACCGGGAATCCTAATGGGAACGACCTGTCTCTGTGGCCAGCTTATAATCTGACTGAGCAGTACCTCCAGCTGGACTTGAACATGAGCCTCGGACAGAGACTCAAAGAACCGCGG
GTGGATTTTTGGACCAGCACCATCCCCCTGATCCTGTCTGCCTCCGACATGCTCCACAGTCCTCTTTCTTCCTTAACTTTCCTCTCTCTCCTCCAGCCTTTCTTTTTCTTTTGTGCTCCTTGAGAAGTTATCTTTCTGTGATTTTGGTTT
CCCTTCTCCTCCCATAATTTCTCCCGCAATCATTAGCTTCTTTCTGAGCTCAGCTGCTTTCTATGGGGATCCTTGCAAAACAAGCTGCTTTCGCTGATATTTTATGGACTTAGGAATGATCCTTACAGAATTCTTTTCAACATCAAAAAG
TGCAATTTGTCTTGGAAGGCAACAAGATTTCTTCAATAAATTTGGAAGAGGGCTGGCCTATTAGTTGTCATAATAATGGTTTTGTAACTCATATGAAATAAAATCAGAATGTAAAATAGG

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for ANKRD11_CES5A

In-frame Fusion Protein Sequences.

N-Truncated Protein (5UTR-3CDS) Sequences

>ANKRD11_CES5A_ENST00000301030_ENST00000521992_89484691_55983814 length=516nt
MHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQT
IGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLN
HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGE
MPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP

>ANKRD11_CES5A_ENST00000378330_ENST00000521992_89484691_55983814 length=516nt
MHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQT
IGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLN
HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGE
MPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for ANKRD11_CES5A

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for ANKRD11_CES5A

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		BRCA	TCGA-A8-A084-01A	ANKRD11	chr16	89484691	-	CES5A	chr16	55983814	-
WashU		BRCA	TCGA-A8-A084-01A	ANKRD11	chr16	89484692	-	CES5A	chr16	55983814	-

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for ANKRD11_CES5A

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status