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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:TMOD3_MCF2 (FusionGDB2 ID:HG29766TG4168)

Fusion Gene Summary for TMOD3_MCF2

Fusion gene summary

Fusion gene information	Fusion gene name: TMOD3_MCF2
	Fusion gene ID: hg29766tg4168
		Hgene	Tgene
	Gene symbol	TMOD3	MCF2
	Gene ID	29766	4168
	Gene name	tropomodulin 3	MCF.2 cell line derived transforming sequence
	Synonyms	UTMOD	ARHGEF21\|DBL
	Cytomap	15q21.2	Xq27.1
	Type of gene	protein-coding	protein-coding
	Description	tropomodulin-3tropomodulin 3 (ubiquitous)ubiquitous tropomodulin	proto-oncogene DBLOncogene MCF2 (oncogene DBL)proto-oncogene MCF-2
	Modification date	20240407	20240403
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000308580, ENST00000544199, ENST00000561136,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 10 X 8 X 9=720	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 3 X 4 X 3=36
	# samples	15	4
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(15/72010)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(4/3610)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: TMOD3 [Title/Abstract] AND MCF2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TMOD3(52122033)-MCF2(138697211), # samples:1

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Fusion Gene Breakpoints for TMOD3_MCF2

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
TMOD3	chr15	52122033	MCF2	chrX	138697211

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for TMOD3_MCF2

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

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Fusion Genomic Features for TMOD3_MCF2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TMOD3	chr15	52122033	+	MCF2	chrX	138697211	-	1.45e-04	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TMOD3	chr15	52122033	+	MCF2	chrX	138697211	-	1.45e-04	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for TMOD3_MCF2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000308580	ENST00000338585	TMOD3	chr15	52122033	+	MCF2	chrX	138697211	-
5UTR-3CDS	ENST00000308580	ENST00000370573	TMOD3	chr15	52122033	+	MCF2	chrX	138697211	-
5UTR-3CDS	ENST00000308580	ENST00000370576	TMOD3	chr15	52122033	+	MCF2	chrX	138697211	-
5UTR-3CDS	ENST00000308580	ENST00000370578	TMOD3	chr15	52122033	+	MCF2	chrX	138697211	-
5UTR-3CDS	ENST00000308580	ENST00000414978	TMOD3	chr15	52122033	+	MCF2	chrX	138697211	-
5UTR-3CDS	ENST00000308580	ENST00000519895	TMOD3	chr15	52122033	+	MCF2	chrX	138697211	-
5UTR-3CDS	ENST00000308580	ENST00000520602	TMOD3	chr15	52122033	+	MCF2	chrX	138697211	-
5UTR-3CDS	ENST00000308580	ENST00000536274	TMOD3	chr15	52122033	+	MCF2	chrX	138697211	-

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000308580	ENST00000338585	TMOD3	chr15	52122033	MCF2	chrX	138697211	0	161
ENST00000308580	ENST00000370573	TMOD3	chr15	52122033	MCF2	chrX	138697211	0	161
ENST00000308580	ENST00000370576	TMOD3	chr15	52122033	MCF2	chrX	138697211	0	461
ENST00000308580	ENST00000370578	TMOD3	chr15	52122033	MCF2	chrX	138697211	0	526
ENST00000308580	ENST00000414978	TMOD3	chr15	52122033	MCF2	chrX	138697211	0	229
ENST00000308580	ENST00000519895	TMOD3	chr15	52122033	MCF2	chrX	138697211	0	617
ENST00000308580	ENST00000520602	TMOD3	chr15	52122033	MCF2	chrX	138697211	0	542
ENST00000308580	ENST00000536274	TMOD3	chr15	52122033	MCF2	chrX	138697211	0	682

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000308580	ENST00000338585	TMOD3	chr15	52122033	MCF2	chrX	138697211	0.00e+00	4.32e-04
ENST00000308580	ENST00000370573	TMOD3	chr15	52122033	MCF2	chrX	138697211	0.00e+00	7.10e-04
ENST00000308580	ENST00000370576	TMOD3	chr15	52122033	MCF2	chrX	138697211	0.00e+00	4.17e-04
ENST00000308580	ENST00000370578	TMOD3	chr15	52122033	MCF2	chrX	138697211	0.00e+00	4.17e-04
ENST00000308580	ENST00000414978	TMOD3	chr15	52122033	MCF2	chrX	138697211	0.00e+00	4.17e-04
ENST00000308580	ENST00000519895	TMOD3	chr15	52122033	MCF2	chrX	138697211	0.00e+00	4.15e-04
ENST00000308580	ENST00000520602	TMOD3	chr15	52122033	MCF2	chrX	138697211	0.00e+00	4.14e-04
ENST00000308580	ENST00000536274	TMOD3	chr15	52122033	MCF2	chrX	138697211	0.00e+00	7.72e-04

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for TMOD3_MCF2

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for TMOD3_MCF2

In-frame Fusion Transcript Sequences.

N-Truncated Transcript (5UTR-3CDS) Sequences

>TMOD3_MCF2_ENST00000308580_ENST00000338585_52122033_138697211 length=1635nt 
 Breakpoint=0nt
GTTCAAATGAAGACTATACAACTCAAGCTTGAAAACATTCGAAGTATATTTGAGAACCAGCAGGCTGGTTTCAGGAACCTGGCAGATAAGCATGTGAGGCCAATCCAATTTGTGGTACCCACACCTGAAAATTTGGTCACATCTGGGACA
CCATTTTTTTCATCTAAACAAGTGGGAGTTGGATACTCTTTCTTTCAAGCATGTAAACTTTTTTCAAAAGGGAAGAAGACTTGGAGACAAAATCAGAGCAACTTAAAAATTGAAGTGGTGCCTGATTGTCAGGAGAAGAGAAGTTCTGGT
CCATCCTCCAGTTTGGACAATGGCAATAGCTTGGATGTTTTAAAGAACCACGTACTAAATGAACTGATACAGACTGAGAGAGTTTATGTTCGAGAACTGTATACTGTTTTGTTGGGTTATAGAGCGGAGATGGATAATCCAGAGATGTTT
GATCTTATGCCACCTCTCCTGAGAAATAAAAAGGACATTCTCTTTGGAAACATGGCAGAAATATATGAATTCCATAACGACATTTTCTTGAGCAGCCTGGAAAATTGTGCTCATGCTCCAGAAAGAGTGGGACCTTGTTTCCTGGAAAGG
AAGGATGATTTTCAGATGTATGCAAAATATTGTCAGAATAAGCCCAGATCAGAAACAATTTGGAGGAAGTATTCAGAATGCGCATTTTTCCAGGAATGTCAAAGAAAGTTAAAACACAGACTTAGACTGGATTCCTATTTACTCAAACCA
GTGCAACGAATCACTAAATATCAGTTATTGTTGAAGGAGCTATTAAAATATAGCAAAGACTGTGAAGGATCTGCTCTGTTGAAGAAGGCACTCGATGCAATGCTGGATTTACTGAAGTCAGTTAATGATTCTATGCATCAGATTGCAATA
AATGGCTATATTGGAAACTTAAATGAACTGGGCAAGATGATAATGCAAGGTGGATTCAGCGTTTGGATAGGGCACAAGAAAGGTGCTACAAAAATGAAGGATTTGGCTAGATTCAAACCAATGCAGCGACACCTTTTCTTGTATGAAAAA
GCCATTGTTTTTTGCAAAAGGCGTGTTGAAAGTGGAGAAGGCTCTGACAGATACCCGTCATACAGTTTTAAACACTGTTGGAAAATGGATGAAGTTGGAATCACTGAATATGTAAAAGGTGATAACCGCAAGTTTGAAATCTGGTATGGT
GAAAAGGAAGAAGTTTATATTGTCCAGGCTTCTAATGTAGATGTGAAGATGACGTGGCTAAAAGAAATAAGAAATATTTTGTTGAAGCAGCAGGAACTTTTGACAGTTAAAAAAAGAAAGCAACAGGATCAATTAACAGAACGGGATAAG
TTTCAGATTTCTCTTCAGCAGAATGATGAAAAGCAACAGGGAGCTTTTATAAGTACTGAGGAAACTGAATTGGAACACACCAGCACTGTGGTGGAGGTCTGTGAGGCAATTGCGTCAGTTCAGGCAGAAGCAAATACAGTTTGGACTGAG
GCATCACAATCTGCAGAAATCTCTGAAGAACCTGCGGAATGGTCAAGCAACTATTTCTACCCTACTTATGATGAAAATGAAGAAGAAAATAGGCCCCTCATGAGACCTGTGTCGGAGATGGCTCTCCTATATTGA

>TMOD3_MCF2_ENST00000308580_ENST00000370573_52122033_138697211 length=1392nt 
 Breakpoint=0nt
GTTCAAATGAAGACTATACAACTCAAGCTTGAAAACATTCGAAGTATATTTGAGAACCAGCAGGCTGGTTTCAGGAACCTGGCAGATAAGCATGTGAGGCCAATCCAATTTGTGGTACCCACACCTGAAAATTTGGTCACATCTGGGACA
CCATTTTTTTCATCTAAACAAGGGAAGAAGACTTGGAGACAAAATCAGAGCAACTTAAAAATTGAAGTGGTGCCTGATTGTCAGGAGAAGAGAAGTTCTGGTCCATCCTCCAGTTTGGACAATGGCAATAGCTTGGATGTTTTAAAGAAC
CACGTACTAAATGAACTGATACAGACTGAGAGAGTTTATGTTCGAGAACTGTATACTGTTTTGTTGGGTTATAGAGCGGAGATGGATAATCCAGAGATGTTTGATCTTATGCCACCTCTCCTGAGAAATAAAAAGGACATTCTCTTTGGA
AACATGGCAGAAATATATGAATTCCATAACGACATTTTCTTGAGCAGCCTGGAAAATTGTGCTCATGCTCCAGAAAGAGTGGGACCTTGTTTCCTGGAAAGGAAGGATGATTTTCAGATGTATGCAAAATATTGTCAGAATAAGCCCAGA
TCAGAAACAATTTGGAGGAAGTATTCAGAATGCGCATTTTTCCAGGAATGTCAAAGAAAGTTAAAACACAGACTTAGACTGGATTCCTATTTACTCAAACCAGTGCAACGAATCACTAAATATCAGTTATTGTTGAAGGAGCTATTAAAA
TATAGCAAAGACTGTGAAGGATCTGCTCTGTTGAAGAAGGCACTCGATGCAATGCTGGATTTACTGAAGTCAGTTAATGATTCTATGCATCAGATTGCAATAAATGGCTATATTGGAAACTTAAATGAACTGGGCAAGATGATAATGCAA
GGTGGATTCAGCGTTTGGATAGGGCACAAGAAAGGTGCTACAAAAATGAAGGATTTGGCTAGATTCAAACCAATGCAGCGACACCTTTTCTTGTATGAAAAAGCCATTGTTTTTTGCAAAAGGCGTGTTGAAAGTGGAGAAGGCTCTGAC
AGATACCCGTCATACAGTTTTAAACACTGTTGGAAAATGGATGAAGTTGGAATCACTGAATATGTAAAAGGTGATAACCGCAAGTTTGAAATCTGGTATGGTGAAAAGGAAGAAGTTTATATTGTCCAGGCTTCTAATGTAGATGTGAAG
ATGACGTGGCTAAAAGAAATAAGAAATATTTTGTTGAAGCAGCAGGAACTTTTGACAGTTAAAAAAAGAAAGCAACAGGATCAATTAACAGAACGGGATAAGTTTCAGATTTCTCTTCAGCAGAATGATGAAGACCTGTGTCGGAGATGG
CTCTCCTATATTGATGAAGCTACTATGTCAAATGGCAAGTAG

>TMOD3_MCF2_ENST00000308580_ENST00000370576_52122033_138697211 length=2287nt 
 Breakpoint=0nt
GTTCAAATGAAGACTATACAACTCAAGCTTGAAAACATTCGAAGTATATTTGAGAACCAGCAGGCTGGTTTCAGGAACCTGGCAGATAAGCATGTGAGGCCAATCCAATTTGTGGTACCCACACCTGAAAATTTGGTCACATCTGGGACA
CCATTTTTTTCATCTAAACAAGGGAAGAAGACTTGGAGACAAAATCAGAGCAACTTAAAAATTGAAGTGGTGCCTGATTGTCAGGAGAAGAGAAGTTCTGGTCCATCCTCCAGTTTGGACAATGGCAATAGCTTGGATGTTTTAAAGAAC
CACGTACTAAATGAACTGATACAGACTGAGAGAGTTTATGTTCGAGAACTGTATACTGTTTTGTTGGGTTATAGAGCGGAGATGGATAATCCAGAGATGTTTGATCTTATGCCACCTCTCCTGAGAAATAAAAAGGACATTCTCTTTGGA
AACATGGCAGAAATATATGAATTCCATAACGACATTTTCTTGAGCAGCCTGGAAAATTGTGCTCATGCTCCAGAAAGAGTGGGACCTTGTTTCCTGGAAAGGAAGGATGATTTTCAGATGTATGCAAAATATTGTCAGAATAAGCCCAGA
TCAGAAACAATTTGGAGGAAGTATTCAGAATGCGCATTTTTCCAGGAATGTCAAAGAAAGTTAAAACACAGACTTAGACTGGATTCCTATTTACTCAAACCAGTGCAACGAATCACTAAATATCAGTTATTGTTGAAGGAGCTATTAAAA
TATAGCAAAGACTGTGAAGGATCTGCTCTGTTGAAGAAGGCACTCGATGCAATGCTGGATTTACTGAAGTCAGTTAATGATTCTATGCATCAGATTGCAATAAATGGCTATATTGGAAACTTAAATGAACTGGGCAAGATGATAATGCAA
GGTGGATTCAGCGTTTGGATAGGGCACAAGAAAGGTGCTACAAAAATGAAGGATTTGGCTAGATTCAAACCAATGCAGCGACACCTTTTCTTGTATGAAAAAGCCATTGTTTTTTGCAAAAGGCGTGTTGAAAGTGGAGAAGGCTCTGAC
AGATACCCGTCATACAGTTTTAAACACTGTTGGAAAATGGATGAAGTTGGAATCACTGAATATGTAAAAGGTGATAACCGCAAGTTTGAAATCTGGTATGGTGAAAAGGAAGAAGTTTATATTGTCCAGGCTTCTAATGTAGATGTGAAG
ATGACGTGGCTAAAAGAAATAAGAAATATTTTGTTGAAGCAGCAGGAACTTTTGACAGTTAAAAAAAGAAAGCAACAGGATCAATTAACAGAACGGGATAAGTTTCAGATTTCTCTTCAGCAGAATGATGAAAAGCAACAGGGAGCTTTT
ATAAGTACTGAGGAAACTGAATTGGAACACACCAGCACTGTGGTGGAGGTCTGTGAGGCAATTGCGTCAGTTCAGGCAGAAGCAAATACAGTTTGGACTGAGGCATCACAATCTGCAGAAATCTCTGAAGAACCTGCGGAATGGTCAAGC
AACTATTTCTACCCTACTTATGATGAAAATGAAGAAGAAAATAGGCCCCTCATGAGACCTGTGTCGGAGATGGCTCTCCTATATTGATGAAGCTACTATGTCAAATGGCAAGTAGCTCTTTCCTGCCTGCTTCTCAGCTCATTTGGAAAA
ATACTGCGCAAAAGACATTGAGCTCAAATGATGCAGATGTTGTTTTCAGGTTAATGGACACGCAAAGAAACCACAGCACATACTTCTTTTCTTTCATTTAATAAAGCTTTTAATTATGGTACGCTGTCTTTTTAAAATCATGTATTTAAT
GTGTCAGATATTGTGCTTGAAAGATTCTCATCTCAGAATACTTTTGGACTTGAAAATTATTTCTTCTCTACTTTGTAACCAAATGCAATCGGTGTGCCTTGGATTATTTAGTTTATTAATGAATTAAGTCAAAATTACGGCTGCAAAATG
GCTAAGGTCAAGTAAAGCACAACATTATGATTTAATATGCTTTTGTTGAAACCACAGCTTTTGTGCCCATTGTTTTAACTTGTGTGAAACAATACAAAGCCCAGAAATTCTTTTCGGGGCATGAGTAAATTTTGTTCAGGGCTACTGTCT
GTATGTGCCCAGATAAAATTTTCATGAGAGTAGTTTACAAAAGCCGTATTTAAAAGTTAATATTTTCACACTTTTTTTCTGGATTTCTGCTTATAATTAATGTAACTTAAATTAGTTGTGCTCTGCTATTTTCTGTATATTTCATGTTGT
AATTCTTTTTTTCAAATAAAAATTAATTCTTCAGGTT

>TMOD3_MCF2_ENST00000308580_ENST00000370578_52122033_138697211 length=2287nt 
 Breakpoint=0nt
GTTCAAATGAAGACTATACAACTCAAGCTTGAAAACATTCGAAGTATATTTGAGAACCAGCAGGCTGGTTTCAGGAACCTGGCAGATAAGCATGTGAGGCCAATCCAATTTGTGGTACCCACACCTGAAAATTTGGTCACATCTGGGACA
CCATTTTTTTCATCTAAACAAGGGAAGAAGACTTGGAGACAAAATCAGAGCAACTTAAAAATTGAAGTGGTGCCTGATTGTCAGGAGAAGAGAAGTTCTGGTCCATCCTCCAGTTTGGACAATGGCAATAGCTTGGATGTTTTAAAGAAC
CACGTACTAAATGAACTGATACAGACTGAGAGAGTTTATGTTCGAGAACTGTATACTGTTTTGTTGGGTTATAGAGCGGAGATGGATAATCCAGAGATGTTTGATCTTATGCCACCTCTCCTGAGAAATAAAAAGGACATTCTCTTTGGA
AACATGGCAGAAATATATGAATTCCATAACGACATTTTCTTGAGCAGCCTGGAAAATTGTGCTCATGCTCCAGAAAGAGTGGGACCTTGTTTCCTGGAAAGGAAGGATGATTTTCAGATGTATGCAAAATATTGTCAGAATAAGCCCAGA
TCAGAAACAATTTGGAGGAAGTATTCAGAATGCGCATTTTTCCAGGAATGTCAAAGAAAGTTAAAACACAGACTTAGACTGGATTCCTATTTACTCAAACCAGTGCAACGAATCACTAAATATCAGTTATTGTTGAAGGAGCTATTAAAA
TATAGCAAAGACTGTGAAGGATCTGCTCTGTTGAAGAAGGCACTCGATGCAATGCTGGATTTACTGAAGTCAGTTAATGATTCTATGCATCAGATTGCAATAAATGGCTATATTGGAAACTTAAATGAACTGGGCAAGATGATAATGCAA
GGTGGATTCAGCGTTTGGATAGGGCACAAGAAAGGTGCTACAAAAATGAAGGATTTGGCTAGATTCAAACCAATGCAGCGACACCTTTTCTTGTATGAAAAAGCCATTGTTTTTTGCAAAAGGCGTGTTGAAAGTGGAGAAGGCTCTGAC
AGATACCCGTCATACAGTTTTAAACACTGTTGGAAAATGGATGAAGTTGGAATCACTGAATATGTAAAAGGTGATAACCGCAAGTTTGAAATCTGGTATGGTGAAAAGGAAGAAGTTTATATTGTCCAGGCTTCTAATGTAGATGTGAAG
ATGACGTGGCTAAAAGAAATAAGAAATATTTTGTTGAAGCAGCAGGAACTTTTGACAGTTAAAAAAAGAAAGCAACAGGATCAATTAACAGAACGGGATAAGTTTCAGATTTCTCTTCAGCAGAATGATGAAAAGCAACAGGGAGCTTTT
ATAAGTACTGAGGAAACTGAATTGGAACACACCAGCACTGTGGTGGAGGTCTGTGAGGCAATTGCGTCAGTTCAGGCAGAAGCAAATACAGTTTGGACTGAGGCATCACAATCTGCAGAAATCTCTGAAGAACCTGCGGAATGGTCAAGC
AACTATTTCTACCCTACTTATGATGAAAATGAAGAAGAAAATAGGCCCCTCATGAGACCTGTGTCGGAGATGGCTCTCCTATATTGATGAAGCTACTATGTCAAATGGCAAGTAGCTCTTTCCTGCCTGCTTCTCAGCTCATTTGGAAAA
ATACTGCGCAAAAGACATTGAGCTCAAATGATGCAGATGTTGTTTTCAGGTTAATGGACACGCAAAGAAACCACAGCACATACTTCTTTTCTTTCATTTAATAAAGCTTTTAATTATGGTACGCTGTCTTTTTAAAATCATGTATTTAAT
GTGTCAGATATTGTGCTTGAAAGATTCTCATCTCAGAATACTTTTGGACTTGAAAATTATTTCTTCTCTACTTTGTAACCAAATGCAATCGGTGTGCCTTGGATTATTTAGTTTATTAATGAATTAAGTCAAAATTACGGCTGCAAAATG
GCTAAGGTCAAGTAAAGCACAACATTATGATTTAATATGCTTTTGTTGAAACCACAGCTTTTGTGCCCATTGTTTTAACTTGTGTGAAACAATACAAAGCCCAGAAATTCTTTTCGGGGCATGAGTAAATTTTGTTCAGGGCTACTGTCT
GTATGTGCCCAGATAAAATTTTCATGAGAGTAGTTTACAAAAGCCGTATTTAAAAGTTAATATTTTCACACTTTTTTTCTGGATTTCTGCTTATAATTAATGTAACTTAAATTAGTTGTGCTCTGCTATTTTCTGTATATTTCATGTTGT
AATTCTTTTTTTCAAATAAAAATTAATTCTTCAGGTT

>TMOD3_MCF2_ENST00000308580_ENST00000414978_52122033_138697211 length=2287nt 
 Breakpoint=0nt
GTTCAAATGAAGACTATACAACTCAAGCTTGAAAACATTCGAAGTATATTTGAGAACCAGCAGGCTGGTTTCAGGAACCTGGCAGATAAGCATGTGAGGCCAATCCAATTTGTGGTACCCACACCTGAAAATTTGGTCACATCTGGGACA
CCATTTTTTTCATCTAAACAAGGGAAGAAGACTTGGAGACAAAATCAGAGCAACTTAAAAATTGAAGTGGTGCCTGATTGTCAGGAGAAGAGAAGTTCTGGTCCATCCTCCAGTTTGGACAATGGCAATAGCTTGGATGTTTTAAAGAAC
CACGTACTAAATGAACTGATACAGACTGAGAGAGTTTATGTTCGAGAACTGTATACTGTTTTGTTGGGTTATAGAGCGGAGATGGATAATCCAGAGATGTTTGATCTTATGCCACCTCTCCTGAGAAATAAAAAGGACATTCTCTTTGGA
AACATGGCAGAAATATATGAATTCCATAACGACATTTTCTTGAGCAGCCTGGAAAATTGTGCTCATGCTCCAGAAAGAGTGGGACCTTGTTTCCTGGAAAGGAAGGATGATTTTCAGATGTATGCAAAATATTGTCAGAATAAGCCCAGA
TCAGAAACAATTTGGAGGAAGTATTCAGAATGCGCATTTTTCCAGGAATGTCAAAGAAAGTTAAAACACAGACTTAGACTGGATTCCTATTTACTCAAACCAGTGCAACGAATCACTAAATATCAGTTATTGTTGAAGGAGCTATTAAAA
TATAGCAAAGACTGTGAAGGATCTGCTCTGTTGAAGAAGGCACTCGATGCAATGCTGGATTTACTGAAGTCAGTTAATGATTCTATGCATCAGATTGCAATAAATGGCTATATTGGAAACTTAAATGAACTGGGCAAGATGATAATGCAA
GGTGGATTCAGCGTTTGGATAGGGCACAAGAAAGGTGCTACAAAAATGAAGGATTTGGCTAGATTCAAACCAATGCAGCGACACCTTTTCTTGTATGAAAAAGCCATTGTTTTTTGCAAAAGGCGTGTTGAAAGTGGAGAAGGCTCTGAC
AGATACCCGTCATACAGTTTTAAACACTGTTGGAAAATGGATGAAGTTGGAATCACTGAATATGTAAAAGGTGATAACCGCAAGTTTGAAATCTGGTATGGTGAAAAGGAAGAAGTTTATATTGTCCAGGCTTCTAATGTAGATGTGAAG
ATGACGTGGCTAAAAGAAATAAGAAATATTTTGTTGAAGCAGCAGGAACTTTTGACAGTTAAAAAAAGAAAGCAACAGGATCAATTAACAGAACGGGATAAGTTTCAGATTTCTCTTCAGCAGAATGATGAAAAGCAACAGGGAGCTTTT
ATAAGTACTGAGGAAACTGAATTGGAACACACCAGCACTGTGGTGGAGGTCTGTGAGGCAATTGCGTCAGTTCAGGCAGAAGCAAATACAGTTTGGACTGAGGCATCACAATCTGCAGAAATCTCTGAAGAACCTGCGGAATGGTCAAGC
AACTATTTCTACCCTACTTATGATGAAAATGAAGAAGAAAATAGGCCCCTCATGAGACCTGTGTCGGAGATGGCTCTCCTATATTGATGAAGCTACTATGTCAAATGGCAAGTAGCTCTTTCCTGCCTGCTTCTCAGCTCATTTGGAAAA
ATACTGCGCAAAAGACATTGAGCTCAAATGATGCAGATGTTGTTTTCAGGTTAATGGACACGCAAAGAAACCACAGCACATACTTCTTTTCTTTCATTTAATAAAGCTTTTAATTATGGTACGCTGTCTTTTTAAAATCATGTATTTAAT
GTGTCAGATATTGTGCTTGAAAGATTCTCATCTCAGAATACTTTTGGACTTGAAAATTATTTCTTCTCTACTTTGTAACCAAATGCAATCGGTGTGCCTTGGATTATTTAGTTTATTAATGAATTAAGTCAAAATTACGGCTGCAAAATG
GCTAAGGTCAAGTAAAGCACAACATTATGATTTAATATGCTTTTGTTGAAACCACAGCTTTTGTGCCCATTGTTTTAACTTGTGTGAAACAATACAAAGCCCAGAAATTCTTTTCGGGGCATGAGTAAATTTTGTTCAGGGCTACTGTCT
GTATGTGCCCAGATAAAATTTTCATGAGAGTAGTTTACAAAAGCCGTATTTAAAAGTTAATATTTTCACACTTTTTTTCTGGATTTCTGCTTATAATTAATGTAACTTAAATTAGTTGTGCTCTGCTATTTTCTGTATATTTCATGTTGT
AATTCTTTTTTTCAAATAAAAATTAATTCTTCAGGTT

>TMOD3_MCF2_ENST00000308580_ENST00000519895_52122033_138697211 length=1809nt 
 Breakpoint=0nt
GTTCAAATGAAGACTATACAACTCAAGCTTGAAAACATTCGAAGTATATTTGAGAACCAGCAGGCTGGTTTCAGGAACCTGGCAGATAAGCATGTGAGGCCAATCCAATTTGTGGTACCCACACCTGAAAATTTGGTCACATCTGGGACA
CCATTTTTTTCATCTAAACAAGTGGGAGTTGGATACTCTTTCTTTCAAGCATGTAAACTTTTTTCAAAAGGGAAGAAGACTTGGAGACAAAATCAGAGCAACTTAAAAATTGAAGTGGTGCCTGATTGTCAGGAGAAGAGAAGTTCTGGT
CCATCCTCCAGTTTGGACAATGGCAATAGCTTGGATGTTTTAAAGAACCACGTACTAAATGAACTGATACAGACTGAGAGAGTTTATGTTCGAGAACTGTATACTGTTTTGTTGGGTTATAGAGCGGAGATGGATAATCCAGAGATGTTT
GATCTTATGCCACCTCTCCTGAGAAATAAAAAGGACATTCTCTTTGGAAACATGGCAGAAATATATGAATTCCATAACGACATTTTCTTGAGCAGCCTGGAAAATTGTGCTCATGCTCCAGAAAGAGTGGGACCTTGTTTCCTGGAAAGG
AAGGATGATTTTCAGATGTATGCAAAATATTGTCAGAATAAGCCCAGATCAGAAACAATTTGGAGGAAGTATTCAGAATGCGCATTTTTCCAGGAATGTCAAAGAAAGTTAAAACACAGACTTAGACTGGATTCCTATTTACTCAAACCA
GTGCAACGAATCACTAAATATCAGTTATTGTTGAAGGAGCTATTAAAATATAGCAAAGACTGTGAAGGATCTGCTCTGTTGAAGAAGGCACTCGATGCAATGCTGGATTTACTGAAGTCAGTTAATGATTCTATGCATCAGATTGCAATA
AATGGCTATATTGGAAACTTAAATGAACTGGGCAAGATGATAATGCAAGGTGGATTCAGCGTTTGGATAGGGCACAAGAAAGGTGCTACAAAAATGAAGGATTTGGCTAGATTCAAACCAATGCAGCGACACCTTTTCTTGTATGAAAAA
GCCATTGTTTTTTGCAAAAGGCGTGTTGAAAGTGGAGAAGGCTCTGACAGATACCCGTCATACAGTTTTAAACACTGTTGGAAAATGGATGAAGTTGGAATCACTGAATATGTAAAAGGTGATAACCGCAAGTTTGAAATCTGGTATGGT
GAAAAGGAAGAAGTTTATATTGTCCAGGCTTCTAATGTAGATGTGAAGATGACGTGGCTAAAAGAAATAAGAAATATTTTGTTGAAGCAGCAGGAACTTTTGACAGTTAAAAAAAGAAAGCAACAGGATCAATTAACAGAACGGGATAAG
TTTCAGATTTCTCTTCAGCAGAATGATGAAAAGCAACAGGGAGCTTTTATAAGTACTGAGGAAACTGAATTGGAACACACCAGCACTGTGGTGGAGGTCTGTGAGGCAATTGCGTCAGTTCAGGCAGAAGCAAATACAGTTTGGACTGAG
GCATCACAATCTGCAGAAATCTCTGAAGAACCTGCGGAATGGTCAAGCAACTATTTCTACCCTACTTATGATGAAAATGAAGAAGAAAATAGGCCCCTCATGAGACCTGTGTCGGAGATGGCTCTCCTATATTGATGAAGCTACTATGTC
AAATGGCAAGTAGCTCTTTCCTGCCTGCTTCTCAGCTCATTTGGAAAAATACTGCGCAAAAGACATTGAGCTCAAATGATGCAGATGTTGTTTTCAGGTTAATGGACACGCAAAGAAACCACAGCACATACTTCTTTTCTTTCATTTAAT
AAAGCTTTT

>TMOD3_MCF2_ENST00000308580_ENST00000520602_52122033_138697211 length=2288nt 
 Breakpoint=0nt
GTTCAAATGAAGACTATACAACTCAAGCTTGAAAACATTCGAAGTATATTTGAGAACCAGCAGGCTGGTTTCAGGAACCTGGCAGATAAGCATGTGAGGCCAATCCAATTTGTGGTACCCACACCTGAAAATTTGGTCACATCTGGGACA
CCATTTTTTTCATCTAAACAAGGGAAGAAGACTTGGAGACAAAATCAGAGCAACTTAAAAATTGAAGTGGTGCCTGATTGTCAGGAGAAGAGAAGTTCTGGTCCATCCTCCAGTTTGGACAATGGCAATAGCTTGGATGTTTTAAAGAAC
CACGTACTAAATGAACTGATACAGACTGAGAGAGTTTATGTTCGAGAACTGTATACTGTTTTGTTGGGTTATAGAGCGGAGATGGATAATCCAGAGATGTTTGATCTTATGCCACCTCTCCTGAGAAATAAAAAGGACATTCTCTTTGGA
AACATGGCAGAAATATATGAATTCCATAACGACATTTTCTTGAGCAGCCTGGAAAATTGTGCTCATGCTCCAGAAAGAGTGGGACCTTGTTTCCTGGAAAGGAAGGATGATTTTCAGATGTATGCAAAATATTGTCAGAATAAGCCCAGA
TCAGAAACAATTTGGAGGAAGTATTCAGAATGCGCATTTTTCCAGGAATGTCAAAGAAAGTTAAAACACAGACTTAGACTGGATTCCTATTTACTCAAACCAGTGCAACGAATCACTAAATATCAGTTATTGTTGAAGGAGCTATTAAAA
TATAGCAAAGACTGTGAAGGATCTGCTCTGTTGAAGAAGGCACTCGATGCAATGCTGGATTTACTGAAGTCAGTTAATGATTCTATGCATCAGATTGCAATAAATGGCTATATTGGAAACTTAAATGAACTGGGCAAGATGATAATGCAA
GGTGGATTCAGCGTTTGGATAGGGCACAAGAAAGGTGCTACAAAAATGAAGGATTTGGCTAGATTCAAACCAATGCAGCGACACCTTTTCTTGTATGAAAAAGCCATTGTTTTTTGCAAAAGGCGTGTTGAAAGTGGAGAAGGCTCTGAC
AGATACCCGTCATACAGTTTTAAACACTGTTGGAAAATGGATGAAGTTGGAATCACTGAATATGTAAAAGGTGATAACCGCAAGTTTGAAATCTGGTATGGTGAAAAGGAAGAAGTTTATATTGTCCAGGCTTCTAATGTAGATGTGAAG
ATGACGTGGCTAAAAGAAATAAGAAATATTTTGTTGAAGCAGCAGGAACTTTTGACAGTTAAAAAAAGAAAGCAACAGGATCAATTAACAGAACGGGATAAGTTTCAGATTTCTCTTCAGCAGAATGATGAAAAGCAACAGGGAGCTTTT
ATAAGTACTGAGGAAACTGAATTGGAACACACCAGCACTGTGGTGGAGGTCTGTGAGGCAATTGCGTCAGTTCAGGCAGAAGCAAATACAGTTTGGACTGAGGCATCACAATCTGCAGAAATCTCTGAAGAACCTGCGGAATGGTCAAGC
AACTATTTCTACCCTACTTATGATGAAAATGAAGAAGAAAATAGGCCCCTCATGAGACCTGTGTCGGAGATGGCTCTCCTATATTGATGAAGCTACTATGTCAAATGGCAAGTAGCTCTTTCCTGCCTGCTTCTCAGCTCATTTGGAAAA
ATACTGCGCAAAAGACATTGAGCTCAAATGATGCAGATGTTGTTTTCAGGTTAATGGACACGCAAAGAAACCACAGCACATACTTCTTTTCTTTCATTTAATAAAGCTTTTAATTATGGTACGCTGTCTTTTTAAAATCATGTATTTAAT
GTGTCAGATATTGTGCTTGAAAGATTCTCATCTCAGAATACTTTTGGACTTGAAAATTATTTCTTCTCTACTTTGTAACCAAATGCAATCGGTGTGCCTTGGATTATTTAGTTTATTAATGAATTAAGTCAAAATTACGGCTGCAAAATG
GCTAAGGTCAAGTAAAGCACAACATTATGATTTAATATGCTTTTGTTGAAACCACAGCTTTTGTGCCCATTGTTTTAACTTGTGTGAAACAATACAAAGCCCAGAAATTCTTTTCGGGGCATGAGTAAATTTTGTTCAGGGCTACTGTCT
GTATGTGCCCAGATAAAATTTTCATGAGAGTAGTTTACAAAAGCCGTATTTAAAAGTTAATATTTTCACACTTTTTTTCTGGATTTCTGCTTATAATTAATGTAACTTAAATTAGTTGTGCTCTGCTATTTTCTGTATATTTCATGTTGT
AATTCTTTTTTTCAAATAAAAATTAATTCTTCAGGTTA

>TMOD3_MCF2_ENST00000308580_ENST00000536274_52122033_138697211 length=2064nt 
 Breakpoint=0nt
GTTCAAATGAAGACTATACAACTCAAGCTTGAAAACATTCGAAGTATATTTGAGAACCAGCAGGCTGGTTTCAGGAACCTGGCAGATAAGCATGTGAGGCCAATCCAATTTGTGGTACCCACACCTGAAAATTTGGTCACATCTGGGACA
CCATTTTTTTCATCTAAACAAGGGAAGAAGACTTGGAGACAAAATCAGAGCAACTTAAAAATTGAAGTGGTGCCTGATTGTCAGGAGAAGAGAAGTTCTGGTCCATCCTCCAGTTTGGACAATGGCAATAGCTTGGATGTTTTAAAGAAC
CACGTACTAAATGAACTGATACAGACTGAGAGAGTTTATGTTCGAGAACTGTATACTGTTTTGTTGGGTTATAGAGCGGAGATGGATAATCCAGAGATGTTTGATCTTATGCCACCTCTCCTGAGAAATAAAAAGGACATTCTCTTTGGA
AACATGGCAGAAATATATGAATTCCATAACGACATTTTCTTGAGCAGCCTGGAAAATTGTGCTCATGCTCCAGAAAGAGTGGGACCTTGTTTCCTGGAAAGGAAGGATGATTTTCAGATGTATGCAAAATATTGTCAGAATAAGCCCAGA
TCAGAAACAATTTGGAGGAAGTATTCAGAATGCGCATTTTTCCAGGAATGTCAAAGAAAGTTAAAACACAGACTTAGACTGGATTCCTATTTACTCAAACCAGTGCAACGAATCACTAAATATCAGTTATTGTTGAAGGAGCTATTAAAA
TATAGCAAAGACTGTGAAGGATCTGCTCTGTTGAAGAAGGCACTCGATGCAATGCTGGATTTACTGAAGTCAGTTAATGATTCTATGCATCAGATTGCAATAAATGGCTATATTGGAAACTTAAATGAACTGGGCAAGATGATAATGCAA
GGTGGATTCAGCGTTTGGATAGGGCACAAGAAAGGTGCTACAAAAATGAAGGATTTGGCTAGATTCAAACCAATGCAGCGACACCTTTTCTTGTATGAAAAAGCCATTGTTTTTTGCAAAAGGCGTGTTGAAAGTGGAGAAGGCTCTGAC
AGATACCCGTCATACAGTTTTAAACACTGTTGGAAAATGGATGAAGTTGGAATCACTGAATATGTAAAAGGTGATAACCGCAAGTTTGAAATCTGGTATGGTGAAAAGGAAGAAGTTTATATTGTCCAGGCTTCTAATGTAGATGTGAAG
ATGACGTGGCTAAAAGAAATAAGAAATATTTTGTTGAAGCAGCAGGAACTTTTGACAGTTAAAAAAAGAAAGCAACAGGATCAATTAACAGAACGGGATAAGTTTCAGATTTCTCTTCAGCAGAATGATGAAGACCTGTGTCGGAGATGG
CTCTCCTATATTGATGAAGCTACTATGTCAAATGGCAAGTAGCTCTTTCCTGCCTGCTTCTCAGCTCATTTGGAAAAATACTGCGCAAAAGACATTGAGCTCAAATGATGCAGATGTTGTTTTCAGGTTAATGGACACGCAAAGAAACCA
CAGCACATACTTCTTTTCTTTCATTTAATAAAGCTTTTAATTATGGTACGCTGTCTTTTTAAAATCATGTATTTAATGTGTCAGATATTGTGCTTGAAAGATTCTCATCTCAGAATACTTTTGGACTTGAAAATTATTTCTTCTCTACTT
TGTAACCAAATGCAATCGGTGTGCCTTGGATTATTTAGTTTATTAATGAATTAAGTCAAAATTACGGCTGCAAAATGGCTAAGGTCAAGTAAAGCACAACATTATGATTTAATATGCTTTTGTTGAAACCACAGCTTTTGTGCCCATTGT
TTTAACTTGTGTGAAACAATACAAAGCCCAGAAATTCTTTTCGGGGCATGAGTAAATTTTGTTCAGGGCTACTGTCTGTATGTGCCCAGATAAAATTTTCATGAGAGTAGTTTACAAAAGCCGTATTTAAAAGTTAATATTTTCACACTT
TTTTTCTGGATTTCTGCTTATAATTAATGTAACTTAAATTAGTTGTGCTCTGCTATTTTCTGTATATTTCATGTTGTAATTCTTTTTTTCAAATAAAAATTAATTCTTCAGGTT

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for TMOD3_MCF2

In-frame Fusion Protein Sequences.

N-Truncated Protein (5UTR-3CDS) Sequences

>TMOD3_MCF2_ENST00000308580_ENST00000338585_52122033_138697211 length=161nt
MTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVA
LHCGSYGYTMA

>TMOD3_MCF2_ENST00000308580_ENST00000370573_52122033_138697211 length=161nt
MTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVA
LHCGSYGYTMA

>TMOD3_MCF2_ENST00000308580_ENST00000370576_52122033_138697211 length=461nt
MKTIQLKLENIRSIFENQQAGFRNLADKHVRPIQFVVPTPENLVTSGTPFFSSKQGKKTWRQNQSNLKIEVVPDCQEKRSSGPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNM
AEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGG
FSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKEEVYIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQNDEDLCRRWLS
YIDEATMSNGK

>TMOD3_MCF2_ENST00000308580_ENST00000370578_52122033_138697211 length=526nt
MKTIQLKLENIRSIFENQQAGFRNLADKHVRPIQFVVPTPENLVTSGTPFFSSKQGKKTWRQNQSNLKIEVVPDCQEKRSSGPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNM
AEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGG
FSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKEEVYIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQNDEKQQGAFIS
TEETELEHTSTVVEVCEAIASVQAEANTVWTEASQSAEISEEPAEWSSNYFYPTYDENEEENRPLMRPVSEMALLY

>TMOD3_MCF2_ENST00000308580_ENST00000414978_52122033_138697211 length=229nt
LKDDDSGDHDQNEENSTQKDGEKEKTERDKNQSSSKRKAVVPGPAEHPLQYNYTFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIRLRKGLASRCWENLILAMLG
EQFMVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKAWEEFHGLVNSSGR

>TMOD3_MCF2_ENST00000308580_ENST00000519895_52122033_138697211 length=617nt
MKDTSIAINHTIITSYSIENLQHECRSILERLQTDGQFALARRVAELAELPVDNLVIKEITQEMQTLKHIEQWSLKQARIDFWKKCHENFKKNSISSKAASSFFSTQAHVACEHPTGWSSMEERHLLLTLAGHWLAQEDVVPLDKLEELE
KQIWLCRITQHTLGRNQEETEPRFSRQISTSGELSFDSLASEFSFSKLAALNTSKYLELNSLPSKETCENRLDWKEQESLNFLIGRLLDDGCVHEASRVCRYFHFYNPDVALVLHCRALASGEASMEDLHPEIHALLQSAELLEEEAPDI
PLRRVHSTSSLDSQKFVTVPSSNEVVTNLEVLTSKCLHGKNYCRQVLCLYDLAKELGCSYTDVAAQDGEAMLRKILASQQPDRCKRAQAFISTQGLKPDTVAELVAEEVTRELLTSSQGTGHKQMFNPTEESQTFLQLTTLCQDRTLVGM
KLLDKISSVPHGELSCTTELLILAHHCFTLTCHMEGIIRVLQAAHMLTDNHLAPSEEYGLVVRLLTGIGRYNEMTYIFDLLHKKHYFEVLMRKKLDPSGTLKTALLDYIKRCRPGDSEKHNMIALCFSMCREIGENHEAAARIQLKLIES
QPWDINNISLLTWSWKT

>TMOD3_MCF2_ENST00000308580_ENST00000520602_52122033_138697211 length=542nt
MKTIQLKLENIRSIFENQQAGFRNLADKHVRPIQFVVPTPENLVTSGTPFFSSKQVGVGYSFFQACKLFSKGKKTWRQNQSNLKIEVVPDCQEKRSSGPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDL
MPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLLKSVNDSMHQIAING
YIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKEEVYIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQ
ISLQQNDEKQQGAFISTEETELEHTSTVVEVCEAIASVQAEANTVWTEASQSAEISEEPAEWSSNYFYPTYDENEEENRPLMRPVSEMALLY

>TMOD3_MCF2_ENST00000308580_ENST00000536274_52122033_138697211 length=682nt
MKDTSIAINHTIITSYSIENLQHECRSILERLQTDGQFALARRVAELAELPVDNLVIKEITQEMQTLKHIEQWSLKQARIDFWKKCHENFKKNSISSKAASSFFSTQAHVACEHPTGWSSMEERHLLLTLAGHWLAQEDVVPLDKLEELE
KQIWLCRITQHTLGRNQEETEPRFSRQISTSGELSFDSLASEFSFSKLAALNTSKYLELNSLPSKETCENRLDWKEQESLNFLIGRLLDDGCVHEASRVCRYFHFYNPDVALVLHCRALASGEASMEDLHPEIHALLQSAELLEEEAPDI
PLRRVHSRHKQMFNPTEESQTFLQLTTLCQDRTLVGMKLLDKISSVPHGELSCTTELLILAHHCFTLTCHMEGIIRVLQAAHMLTDNHLAPSEEYGLVVRLLTGIGRYNEMTYIFDLLHKKHYFEVLMRKKLDPSGTLKTALLDYIKRCR
PGDSEKHNMIALCFSMCREIGENHEAAARIQLKLIESQPWEDSLKDGHQLKQLLLKALTLMLDAAESYAKDSCVRQAQHCQRLTKLITLQIHFLNTGQNTMLINLGRHKLMDCILALPRFYQASIVAEAYDFVPDWAEILYQQVILKGDF
NYLEEFKQQRLLKSSIFEEISKKYKQHQPTDMVMENLKKLLTYCEDVYLYYKLAYEHKFYEIVNVLLKDPQTGCCLKDMLAG

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for TMOD3_MCF2

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for TMOD3_MCF2

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
NCBI		GenBank	X13230.1	TMOD3	chr15	52122033	+	MCF2	chrX	138697211	-

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for TMOD3_MCF2

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status