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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IGLC3-AR (FusionGDB2 ID:HG3539TG367)

Fusion Gene Summary for IGLC3-AR

check button Fusion gene summary
Fusion gene informationFusion gene name: IGLC3-AR
Fusion gene ID: hg3539tg367
HgeneTgene
Gene symbol

IGLC3

AR

Gene ID

3539

367

Gene nameandrogen receptor
SynonymsAIS|AR8|DHTR|HUMARA|HYSP1|KD|NR3C4|SBMA|SMAX1|TFM
Cytomap('IGLC3')('AR')

Xq12

Type of geneprotein-coding
Descriptionandrogen receptordihydrotestosterone receptornuclear receptor subfamily 3 group C member 4
Modification date20200329
UniProtAcc

P0DOY3

.
Ensembl transtripts involved in fusion geneENST00000390325, 
Fusion gene scores* DoF score1 X 1 X 1=114 X 10 X 11=1540
# samples 116
** MAII scorelog2(1/1*10)=3.32192809488736log2(16/1540*10)=-3.2667865406949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IGLC3 [Title/Abstract] AND AR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIGLC3(23248961)-AR(66764976), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAR

GO:0006351

transcription, DNA-templated

15572661

TgeneAR

GO:0008284

positive regulation of cell proliferation

17277772

TgeneAR

GO:0010628

positive regulation of gene expression

24681825

TgeneAR

GO:0030521

androgen receptor signaling pathway

19886863|20048160

TgeneAR

GO:0030522

intracellular receptor signaling pathway

17277772

TgeneAR

GO:0045720

negative regulation of integrin biosynthetic process

21310825

TgeneAR

GO:0045726

positive regulation of integrin biosynthetic process

21310825

TgeneAR

GO:0045893

positive regulation of transcription, DNA-templated

11477070|12799378

TgeneAR

GO:0045944

positive regulation of transcription by RNA polymerase II

12799378|16728402|17505061|20048160|20181722

TgeneAR

GO:0045945

positive regulation of transcription by RNA polymerase III

18487222

TgeneAR

GO:1903076

regulation of protein localization to plasma membrane

21310825

TgeneAR

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

21310825



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THYMTCGA-XM-A8R8IGLC3chr22

23248961

+ARchrX

66764976

+
ChimerDB4UCECTCGA-A5-A2K3-01AIGLC3chr22

23248961

+ARchrX

66764976

+


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Fusion Gene ORF analysis for IGLC3-AR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000390325ENST00000513847IGLC3chr22

23248961

+ARchrX

66764976

+
3UTR-5UTRENST00000390325ENST00000374690IGLC3chr22

23248961

+ARchrX

66764976

+
3UTR-5UTRENST00000390325ENST00000504326IGLC3chr22

23248961

+ARchrX

66764976

+
3UTR-intronENST00000390325ENST00000396043IGLC3chr22

23248961

+ARchrX

66764976

+
3UTR-intronENST00000390325ENST00000396044IGLC3chr22

23248961

+ARchrX

66764976

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for IGLC3-AR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for IGLC3-AR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:23248961/:66764976)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGLC3

P0DOY3

.
FUNCTION: Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for IGLC3-AR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for IGLC3-AR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IGLC3-AR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IGLC3-AR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0039585Androgen-Insensitivity Syndrome74CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0268301Reifenstein Syndrome41CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0033578Prostatic Neoplasms21CTD_human
TgeneC0376358Malignant neoplasm of prostate21CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0011570Mental Depression5PSYGENET
TgeneC0011581Depressive disorder5PSYGENET
TgeneC3658266Prostatic Cancer, Castration-Resistant4CTD_human
TgeneC3658267Prostatic Neoplasms, Castration-Resistant4CTD_human
TgeneC0021364Male infertility3CTD_human
TgeneC0236663Alcohol withdrawal syndrome3PSYGENET
TgeneC0848676Subfertility, Male3CTD_human
TgeneC0917731Male sterility3CTD_human
TgeneC0001973Alcoholic Intoxication, Chronic2PSYGENET
TgeneC0006142Malignant neoplasm of breast2CTD_human;UNIPROT
TgeneC0238033Carcinoma of Male Breast2CTD_human
TgeneC0242788Breast Neoplasms, Male2CTD_human
TgeneC0678222Breast Carcinoma2CTD_human
TgeneC0936016Testicular Feminization2CTD_human
TgeneC1257931Mammary Neoplasms, Human2CTD_human
TgeneC1458155Mammary Neoplasms2CTD_human
TgeneC2713546Androgen Receptor Deficiency2CTD_human
TgeneC4704874Mammary Carcinoma, Human2CTD_human
TgeneC0002170Alopecia1CTD_human
TgeneC0004114Astrocytoma1CTD_human
TgeneC0004352Autistic Disorder1CTD_human
TgeneC0017412Genital Diseases, Male1CTD_human
TgeneC0020538Hypertensive disease1CTD_human
TgeneC0021361Female infertility1CTD_human
TgeneC0021655Insulin Resistance1CTD_human
TgeneC0023418leukemia1CTD_human
TgeneC0027643Neoplasm Recurrence, Local1CTD_human
TgeneC0038279Sterility, Postpartum1CTD_human
TgeneC0085207Gestational Diabetes1CTD_human
TgeneC0086873Pseudopelade1CTD_human
TgeneC0162311Androgenetic Alopecia1CTD_human
TgeneC0205768Subependymal Giant Cell Astrocytoma1CTD_human
TgeneC0263477Female pattern alopecia (disorder)1CTD_human
TgeneC0280783Juvenile Pilocytic Astrocytoma1CTD_human
TgeneC0280785Diffuse Astrocytoma1CTD_human
TgeneC0282612Prostatic Intraepithelial Neoplasias1CTD_human
TgeneC0334579Anaplastic astrocytoma1CTD_human
TgeneC0334580Protoplasmic astrocytoma1CTD_human
TgeneC0334581Gemistocytic astrocytoma1CTD_human
TgeneC0334582Fibrillary Astrocytoma1CTD_human
TgeneC0334583Pilocytic Astrocytoma1CTD_human
TgeneC0338070Childhood Cerebral Astrocytoma1CTD_human
TgeneC0341869Subfertility, Female1CTD_human
TgeneC0525045Mood Disorders1PSYGENET
TgeneC0547065Mixed oligoastrocytoma1CTD_human
TgeneC0556385Craving for alcohol1PSYGENET
TgeneC0750935Cerebral Astrocytoma1CTD_human
TgeneC0750936Intracranial Astrocytoma1CTD_human
TgeneC0917730Female sterility1CTD_human
TgeneC0920563Insulin Sensitivity1CTD_human
TgeneC1704230Grade I Astrocytoma1CTD_human
TgeneC2239176Liver carcinoma1CTD_human
TgeneC4083212Alopecia, Male Pattern1CTD_human