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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:MAN1A1_MAGT1 (FusionGDB2 ID:HG4121TG84061)

Fusion Gene Summary for MAN1A1_MAGT1

Fusion gene summary

Fusion gene information	Fusion gene name: MAN1A1_MAGT1
	Fusion gene ID: hg4121tg84061
		Hgene	Tgene
	Gene symbol	MAN1A1	MAGT1
	Gene ID	4121	84061
	Gene name	mannosidase alpha class 1A member 1	magnesium transporter 1
	Synonyms	HUMM3\|HUMM9\|MAN9	CDG1CC\|IAP\|MRX95\|OST3B\|PRO0756\|SLC58A1\|XMEN\|bA217H1.1
	Cytomap	6q22.31	Xq21.1
	Type of gene	protein-coding	protein-coding
	Description	mannosyl-oligosaccharide 1,2-alpha-mannosidase IAMan9-mannosidasealpha-1,2-mannosidase IAman(9)-alpha-mannosidaseprocessing alpha-1,2-mannosidase IA	magnesium transporter protein 1dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1implantation-associated proteinoligosaccharyl transferase subunit MAGT1oligosaccharyltransferase 3 homolog B
	Modification date	20240305	20240407
	UniProtAcc	P33908	.
	Ensembl transtripts involved in fusion gene	ENST00000368466, ENST00000368468,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 10 X 15 X 9=1350	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 3 X 9 X 8=216
	# samples	15	14
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(15/135010)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(14/21610)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MAN1A1 [Title/Abstract] AND MAGT1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MAN1A1(119611847)-MAGT1(77086392), # samples:1

Fusion gene breakpoints across MAN1A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MAGT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for MAN1A1_MAGT1

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
MAN1A1	chr6	119611847	MAGT1	chrX	77086392
MAN1A1	chr6	119611848	MAGT1	chrX	77086392
MAN1A1	chr6	119290683	MAGT1	chrX	77830895

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for MAN1A1_MAGT1

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
MAN1A1-MAGT1	Promoter / Enhancer Hijacking M6		Promoter swap alters mannosidase alpha class 1A member 1 alongside MAGT1 magnesium transporter, modifying N-glycosylation and magnesium influx.		Glycosylation pathway inhibitors; magnesium modulators		Solid tumors

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
MAN1A1-MAGT1	Promoter / Enhancer Hijacking		Promoter swap alters mannosidase alpha class 1A member 1 alongside MAGT1 magnesium transporter, modifying N-glycosylation and magnesium influx.	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 38896122; Title: HLH and Recurrent EBV Lymphoma as the presenting manifestation of MAGT1 Deficiency: A Systematic Review of the Expanding Disease Spectrum.	Glycosylation pathway inhibitors; magnesium modulators		Solid tumors	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 35796007; Title: Transcription factor KLF16 activates MAGT1 to regulate the tumorigenesis and progression of breast cancer.; PMID: 35416125; Title: Oncogenic magnesium transporter 1 upregulates programmed death-1-ligand 1 expression and contributes to growth and radioresistance of glioma cells through the ERK/MAPK signaling pathway.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAN1A1 P33908	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MAN1A1	GO:0036503	ERAD pathway	27108681
Hgene	MAN1A1	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	27108681
Tgene	MAGT1	GO:0006487	protein N-linked glycosylation	31831667

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Fusion Genomic Features for MAN1A1_MAGT1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
MAN1A1	chr6	119611847	-	MAGT1	chrX	77086392	-	6.18e-06	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for MAN1A1_MAGT1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000368466	ENST00000358075	MAN1A1	chr6	119611847	-	MAGT1	chrX	77086392	-
In-frame	ENST00000368468	ENST00000358075	MAN1A1	chr6	119611847	-	MAGT1	chrX	77086392	-

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000368466	ENST00000358075	MAN1A1	chr6	119611847	MAGT1	chrX	77086392	1383	387
ENST00000368468	ENST00000358075	MAN1A1	chr6	119611847	MAGT1	chrX	77086392	1339	419

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000368466	ENST00000358075	MAN1A1	chr6	119611847	MAGT1	chrX	77086392	2.05e-03	9.98e-01
ENST00000368468	ENST00000358075	MAN1A1	chr6	119611847	MAGT1	chrX	77086392	2.16e-03	9.98e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for MAN1A1_MAGT1

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MAGT1

chr6:119611847

chrX:77086392

ENST00000358075

Q9H0U3

47_175

332.3333333333333

368.0

Domain

Note=Thioredoxin

Tgene

MAGT1

chr6:119611847

chrX:77086392

ENST00000358075

Q9H0U3

206_209

332.3333333333333

368.0

Topological domain

Cytoplasmic

Tgene

MAGT1

chr6:119611847

chrX:77086392

ENST00000358075

Q9H0U3

231_270

332.3333333333333

368.0

Topological domain

Extracellular

Tgene

MAGT1

chr6:119611847

chrX:77086392

ENST00000358075

Q9H0U3

292_300

332.3333333333333

368.0

Topological domain

Cytoplasmic

Tgene

MAGT1

chr6:119611847

chrX:77086392

ENST00000358075

Q9H0U3

30_184

332.3333333333333

368.0

Topological domain

Extracellular

Tgene

MAGT1

chr6:119611847

chrX:77086392

ENST00000358075

Q9H0U3

322_335

332.3333333333333

368.0

Topological domain

Extracellular

Tgene

MAGT1

chr6:119611847

chrX:77086392

ENST00000358075

Q9H0U3

185_205

332.3333333333333

368.0

Transmembrane

Helical

Tgene

MAGT1

chr6:119611847

chrX:77086392

ENST00000358075

Q9H0U3

210_230

332.3333333333333

368.0

Transmembrane

Helical

Tgene

MAGT1

chr6:119611847

chrX:77086392

ENST00000358075

Q9H0U3

271_291

332.3333333333333

368.0

Transmembrane

Helical

Tgene

MAGT1

chr6:119611847

chrX:77086392

ENST00000358075

Q9H0U3

301_321

332.3333333333333

368.0

Transmembrane

Helical

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for MAN1A1_MAGT1

In-frame Fusion Transcript Sequences.

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392 length=4346nt 
 Breakpoint=1383nt
GTACCGTGCTGCTCTACTCGCTGCCATTCGCCCGCAGGTCGGCGCGCTCGCCCACCTGAGCCGCGCCGGGGCTGCGGGACCGTGGGACAGCGCGCTCAGCCCAGCCTAGGAAAGAGGCAGCAGTCTCAGCGCGGAGATGGGGAGCGGGCG
AAGTTGACGAGTCTCCCGCCCACGCTGCGCCCCTCCTGCCCAGAGGGGCTGCAGCCAGCGGTCTGTCGCGCGTGCCTGTGTGCCCGAGGAGCCGCCCCGGGGAGAAGACCCGGCGCGGAGTTGTTCCCCCAGGGAGGATCCGCAGCCCAG
CCGAGGGGGTCGGGCGGCCTGGCTACGCAGGACCCAGCCCCGCAGCCGCGGACTCCCAGCGGCGGCGAAGTTTGGCTGCTGAGCGGCGCGGCGCCGGACCACTGGACAGCGGGAGCGATGCCCGTGGGGGGCCTGTTGCCGCTCTTCAGC
AGCCCCGCGGGCGGCGTCCTGGGCGGGGGGCTCGGCGGCGGCGGTGGCAGGAAGGGGTCGGGCCCCGCCGCCCTCCGCCTGACGGAGAAGTTCGTGCTGCTGCTGGTATTCAGCGCCTTCATCACGCTCTGCTTCGGGGCGATCTTCTTC
CTGCCAGACTCCTCCAAGCTGCTCAGCGGGGTCCTGTTCCACTCCAGCCCCGCCTTGCAGCCGGCCGCCGACCACAAGCCCGGGCCCGGGGCGCGCGCCGAGGACGCGGCCGAGGGGCGAGCCCGGCGCCGCGAGGAGGGGGCACCCGGG
GACCCGGAGGCCGCCCTGGAGGACAACTTGGCCAGGATCCGCGAAAACCACGAGCGGGCTCTCAGGGAAGCCAAGGAGACCCTGCAGAAGCTGCCCGAGGAGATCCAAAGAGACATCCTACTGGAGAAGAAGAAGGTGGCCCAGGACCAG
CTGCGTGACAAGGCGCCGTTCAGAGGCCTGCCCCCGGTGGACTTCGTGCCCCCAATCGGGGTGGAGAGCCGGGAGCCCGCCGACGCCGCCATCCGCGAGAAAAGGGCAAAGATCAAAGAGGAAATTGAAGCCAGGAAGGGGCAAGCAAAT
TGCCCAGGGTCGAGCAGCTCCTGCGAGGTTGAAATCCAGATGATGAAACATGCTTGGAATAATTATAAAGGTTATGCCTGGGGATTAAATGAACTCAAACCTATATCAAAAGGAGGCCATTCAAGCAGTTTGTTTGGTAACATCAAAGGA
GCAACTATAGTAGATGCCCTGGATACACTTTTTATTATGGAAATGAAACATGAATTTGAAGAAGCAAAATCATGGGTTGAAGAAAATTTAGATTTTAATGTGAATGCTGAAATTTCTGTCTTTGAAGTAAATATACGCTTTGTTGGTGGA
CTACTCTCAGCCTACTATCTGTCTGGAGAAGAGTAATGTGTGTGGCTGGTATTGGACTTGTTGTATTATTCTTCAGTTGGATGCTCTCTATTTTTAGATCTAAATATCATGGCTACCCATACAGCTTTCTGATGAGTTAAAAAGGTCCCA
GAGATATATAGACACTGGAGTACTGGAAATTGAAAAACGAAAATCGTGTGTGTTTGAAAAGAAGAATGCAACTTGTATATTTTGTATTACCTCTTTTTTTCAAGTGATTTAAATAGTTAATCATTTAACCAAAGAAGATGTGTAGTGCCT
TAACAAGCAATCCTCTGTCAAAATCTGAGGTATTTGAAAATAATTATCCTCTTAACCTTCTCTTCCCAGTGAACTTTATGGAACATTTAATTTAGTACAATTAAGTATATTATAAAAATTGTAAAACTACTACTTTGTTTTAGTTAGAAC
AAAGCTCAAAACTACTTTAGTTAACTTGGTCATCTGATTTTATATTGCCTTATCCAAAGATGGGGAAAGTAAGTCCTGACCAGGTGTTCCCACATATGCCTGTTACAGATAACTACATTAGGAATTCATTCTTAGCTTCTTCATCTTTGT
GTGGATGTGTATACTTTACGCATCTTTCCTTTTGAGTAGAGAAATTATGTGTGTCATGTGGTCTTCTGAAAATGGAACACCATTCTTCAGAGCACACGTCTAGCCCTCAGCAAGACAGTTGTTTCTCCTCCTCCTTGCATATTTCCTACT
GAAATACAGTGCTGTCTATGATTGTTTTTGTTTTGTTGTTTTTTTGAGACGGTCTCGCTGTGTCACACAGGCTGGAGTGCAGTGGCGTGAGCTCGGCTGACTGCAAACTCTGCCTCCCAGGTTTAAGCGATTCTCCTGTCACAGCTTCCC
AAGTAGCTGGGATTTACAGGTGTGCACCGCCATGCCAGGCTAATTTTTGTGTTTTTAGTAGAGACAGGGTTTCGCCAAGTTGTCCAGGCTGGTCTTGAACTCCTGGGCTCAAGTGATCCGCCCGCCTCAGTCTCCCAAAGTGCGAGGATG
ACATGTGTGAGCTACCACACCAGCAATGTCTATGCTTCTCGATAGCTGTGAACATGAAAAGACATCTATTGGGAGTCCGAGGCAGGTGGATTGCTTGAGGCCAGGAGTTAGAGACCAGCCTGGCCAACAAGGCAAAACCCCGTCTCTACT
AAAAATATGAAAATTAGCTGGGCTTGGTGGCTCATGCCTATAATCCTAGCTACTTGGGAGGCTGAGGCACGAGACTTGCTTAATACCTGGGAGGCGGAGATTGCAGTGAGCCGAGATCACGCTACTGCGCTCCAGCCTGAGTGATAGAGT
GAGACTCTGTCTCAAAAAAAAGTATCTCTAAATACAGGATTATAATTTCTGCTTGAGTATGGTGTTAACTACCTTGTATTTAGAAAGATTTCAGATTCATTCCATCTCCTTAGTTTTCTTTTAAGGTGACCCATCTGTGATAAAAATATA
GCTTAGTGCTAAAATCAGTGTAACTTATACATGGCCTAAAATGTTTCTACAAATTAGAGTTTGTCACTTATTCCATTTGTACCTAAGAGAAAAATAGGCTCAGTTAGAAAAGGACTCCCTGGCCAGGCGCAGTGACTTACGCCTGTAATC
TCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACGAGGTCAGGAGTTCGAGACCATCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATATAAAAATTAGCTGGGTGTGGTGGCAGGAGCCTGTAATCCCAGCTACACAGGAGGC
TGAGGCACGAGAATCACTTGAACTCAGGAGATGGAGGTTTCAGTGAGCCAAGATCACACCACTGCACTCCAGCCTGGCAACAGAGCGAGACTCCATCTCAAAAAAAAAAAAAAAAGTAAGAAAGAAAAGGACTCCCTTAGAATGGGAAAG
AAAAATCATAAAATATTGAGCTGATGCCTGTATATAGAAATTAAGCGTTTCTCGAAAGCTGTTCTATGTTTTGCTGTTATTTTAGTCTTTATTCTCTTCCTTTAGGTGGAGAAACAAAGTACCAATTTGAAGGGATTTTTTTTATTTTGT
CTTTTGGTTTCTGTCAGTAGAAATAACCATATGTGCTAACCAAATTTCTGTGAAGAATGTTTTCATGGTTATCATTATATCTAACTATAACCTCCCCCATAGTTATGAAGAGTAACCTGAAATGCCACTATTGTGGAAATAGGATAATTG
TAATTGTGAAAAAATAATTTTAAGGAAATCTTACAAGTATTACATTAAAAAGATACTATGACTGCCACCTGCCATTTACCTTCTAATAACCCTGCCATGTGGTTTGCAGAAAGAGATGGATATAGTAGCCTCAGAAGAAATATTTTATGT
GGGTTTTTTGTTTTTCGTTACTAGATTTCATGGATGAGGGGATATGGTTGACCTTTTACTTTTTAATGGAGCAGCCAGTTTTTGTTAATTACTCACTTGTAAATTGTGAGATTCTGAATTCCTTACCTGCTATTCTTGTACTTGTCTCAG
GCCAAATCTATGCTGTGGTTCTTATGAGACTTGTATGAAGATGCCCTGATTTGTACAGATTGACCACGGGAATACTACTGCCATGTAATCTGTATAGTTCCAGATAATTTGTCATGAACATTGACAGAATGACAATTTTTTGTATTTGCT
TTTTCTCCCTTTAAGAGCACATTCTTCTGTAAGGAGAAAGGCAGCATTCTGGCTAAAATGTGTAGAAGGTAATTTACTACACTTATAAAATAGTGTGACTTTTGTGAAAATTTTGAATTAGCTTTCATATGAAGTGCCTTAAGTAGACTC
TTCATTTACTTTTCTGGTAATGGTTTAAATATCATTTGTTATGCATTTTTAAGATACAGTTCAGAATGACACATTGTAGTGGCAAAGATAACCAAATGTCTGGCTGTTTGCTTTTTGACCATATCAATAAACTTTTACAATCTAAA

>MAN1A1_MAGT1_ENST00000368468_ENST00000358075_119611847_77086392 length=4302nt 
 Breakpoint=1339nt
AGTGCTCGCGGGGCCGCGGCGGAGTGTACCGTGCTGCTCTACTCGCTGCCATTCGCCCGCAGGTCGGCGCGCTCGCCCACCTGAGCCGCGCCGGGGCTGCGGGACCGTGGGACAGCGCGCTCAGCCCAGCCTAGGAAAGAGGCAGCAGTC
TCAGCGCGGAGATGGGGAGCGGGCGAAGTTGACGAGTCTCCCGCCCACGCTGCGCCCCTCCTGCCCAGAGGGGCTGCAGCCAGCGGTCTGTCGCGCGTGCCTGTGTGCCCGAGGAGCCGCCCCGGGGAGAAGACCCGGCGCGGAGTTGTT
CCCCCAGGGAGGATCCGCAGCCCAGCCGAGGGGGTCGGGCGGCCTGGCTACGCAGGACCCAGCCCCGCAGCCGCGGACTCCCAGCGGCGGCGAAGTTTGGCTGCTGAGCGGCGCGGCGCCGGACCACTGGACAGCGGGAGCGATGCCCGT
GGGGGGCCTGTTGCCGCTCTTCAGCAGCCCCGCGGGCGGCGTCCTGGGCGGGGGGCTCGGCGGCGGCGGTGGCAGGAAGGGGTCGGGCCCCGCCGCCCTCCGCCTGACGGAGAAGTTCGTGCTGCTGCTGGTATTCAGCGCCTTCATCAC
GCTCTGCTTCGGGGCGATCTTCTTCCTGCCAGACTCCTCCAAGCTGCTCAGCGGGGTCCTGTTCCACTCCAGCCCCGCCTTGCAGCCGGCCGCCGACCACAAGCCCGGGCCCGGGGCGCGCGCCGAGGACGCGGCCGAGGGGCGAGCCCG
GCGCCGCGAGGAGGGGGCACCCGGGGACCCGGAGGCCGCCCTGGAGGACAACTTGGCCAGGATCCGCGAAAACCACGAGCGGGCTCTCAGGGAAGCCAAGGAGACCCTGCAGAAGCTGCCCGAGGAGATCCAAAGAGACATCCTACTGGA
GAAGAAGAAGGTGGCCCAGGACCAGCTGCGTGACAAGGCGCCGTTCAGAGGCCTGCCCCCGGTGGACTTCGTGCCCCCAATCGGGGTGGAGAGCCGGGAGCCCGCCGACGCCGCCATCCGCGAGAAAAGGGCAAAGATCAAAGAGATGAT
GAAACATGCTTGGAATAATTATAAAGGTTATGCCTGGGGATTAAATGAACTCAAACCTATATCAAAAGGAGGCCATTCAAGCAGTTTGTTTGGTAACATCAAAGGAGCAACTATAGTAGATGCCCTGGATACACTTTTTATTATGGAAAT
GAAACATGAATTTGAAGAAGCAAAATCATGGGTTGAAGAAAATTTAGATTTTAATGTGAATGCTGAAATTTCTGTCTTTGAAGTAAATATACGCTTTGTTGGTGGACTACTCTCAGCCTACTATCTGTCTGGAGAAGAGTAATGTGTGTG
GCTGGTATTGGACTTGTTGTATTATTCTTCAGTTGGATGCTCTCTATTTTTAGATCTAAATATCATGGCTACCCATACAGCTTTCTGATGAGTTAAAAAGGTCCCAGAGATATATAGACACTGGAGTACTGGAAATTGAAAAACGAAAAT
CGTGTGTGTTTGAAAAGAAGAATGCAACTTGTATATTTTGTATTACCTCTTTTTTTCAAGTGATTTAAATAGTTAATCATTTAACCAAAGAAGATGTGTAGTGCCTTAACAAGCAATCCTCTGTCAAAATCTGAGGTATTTGAAAATAAT
TATCCTCTTAACCTTCTCTTCCCAGTGAACTTTATGGAACATTTAATTTAGTACAATTAAGTATATTATAAAAATTGTAAAACTACTACTTTGTTTTAGTTAGAACAAAGCTCAAAACTACTTTAGTTAACTTGGTCATCTGATTTTATA
TTGCCTTATCCAAAGATGGGGAAAGTAAGTCCTGACCAGGTGTTCCCACATATGCCTGTTACAGATAACTACATTAGGAATTCATTCTTAGCTTCTTCATCTTTGTGTGGATGTGTATACTTTACGCATCTTTCCTTTTGAGTAGAGAAA
TTATGTGTGTCATGTGGTCTTCTGAAAATGGAACACCATTCTTCAGAGCACACGTCTAGCCCTCAGCAAGACAGTTGTTTCTCCTCCTCCTTGCATATTTCCTACTGAAATACAGTGCTGTCTATGATTGTTTTTGTTTTGTTGTTTTTT
TGAGACGGTCTCGCTGTGTCACACAGGCTGGAGTGCAGTGGCGTGAGCTCGGCTGACTGCAAACTCTGCCTCCCAGGTTTAAGCGATTCTCCTGTCACAGCTTCCCAAGTAGCTGGGATTTACAGGTGTGCACCGCCATGCCAGGCTAAT
TTTTGTGTTTTTAGTAGAGACAGGGTTTCGCCAAGTTGTCCAGGCTGGTCTTGAACTCCTGGGCTCAAGTGATCCGCCCGCCTCAGTCTCCCAAAGTGCGAGGATGACATGTGTGAGCTACCACACCAGCAATGTCTATGCTTCTCGATA
GCTGTGAACATGAAAAGACATCTATTGGGAGTCCGAGGCAGGTGGATTGCTTGAGGCCAGGAGTTAGAGACCAGCCTGGCCAACAAGGCAAAACCCCGTCTCTACTAAAAATATGAAAATTAGCTGGGCTTGGTGGCTCATGCCTATAAT
CCTAGCTACTTGGGAGGCTGAGGCACGAGACTTGCTTAATACCTGGGAGGCGGAGATTGCAGTGAGCCGAGATCACGCTACTGCGCTCCAGCCTGAGTGATAGAGTGAGACTCTGTCTCAAAAAAAAGTATCTCTAAATACAGGATTATA
ATTTCTGCTTGAGTATGGTGTTAACTACCTTGTATTTAGAAAGATTTCAGATTCATTCCATCTCCTTAGTTTTCTTTTAAGGTGACCCATCTGTGATAAAAATATAGCTTAGTGCTAAAATCAGTGTAACTTATACATGGCCTAAAATGT
TTCTACAAATTAGAGTTTGTCACTTATTCCATTTGTACCTAAGAGAAAAATAGGCTCAGTTAGAAAAGGACTCCCTGGCCAGGCGCAGTGACTTACGCCTGTAATCTCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACGAGGTCAGGA
GTTCGAGACCATCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATATAAAAATTAGCTGGGTGTGGTGGCAGGAGCCTGTAATCCCAGCTACACAGGAGGCTGAGGCACGAGAATCACTTGAACTCAGGAGATGGAGGTTTCAGT
GAGCCAAGATCACACCACTGCACTCCAGCCTGGCAACAGAGCGAGACTCCATCTCAAAAAAAAAAAAAAAAGTAAGAAAGAAAAGGACTCCCTTAGAATGGGAAAGAAAAATCATAAAATATTGAGCTGATGCCTGTATATAGAAATTAA
GCGTTTCTCGAAAGCTGTTCTATGTTTTGCTGTTATTTTAGTCTTTATTCTCTTCCTTTAGGTGGAGAAACAAAGTACCAATTTGAAGGGATTTTTTTTATTTTGTCTTTTGGTTTCTGTCAGTAGAAATAACCATATGTGCTAACCAAA
TTTCTGTGAAGAATGTTTTCATGGTTATCATTATATCTAACTATAACCTCCCCCATAGTTATGAAGAGTAACCTGAAATGCCACTATTGTGGAAATAGGATAATTGTAATTGTGAAAAAATAATTTTAAGGAAATCTTACAAGTATTACA
TTAAAAAGATACTATGACTGCCACCTGCCATTTACCTTCTAATAACCCTGCCATGTGGTTTGCAGAAAGAGATGGATATAGTAGCCTCAGAAGAAATATTTTATGTGGGTTTTTTGTTTTTCGTTACTAGATTTCATGGATGAGGGGATA
TGGTTGACCTTTTACTTTTTAATGGAGCAGCCAGTTTTTGTTAATTACTCACTTGTAAATTGTGAGATTCTGAATTCCTTACCTGCTATTCTTGTACTTGTCTCAGGCCAAATCTATGCTGTGGTTCTTATGAGACTTGTATGAAGATGC
CCTGATTTGTACAGATTGACCACGGGAATACTACTGCCATGTAATCTGTATAGTTCCAGATAATTTGTCATGAACATTGACAGAATGACAATTTTTTGTATTTGCTTTTTCTCCCTTTAAGAGCACATTCTTCTGTAAGGAGAAAGGCAG
CATTCTGGCTAAAATGTGTAGAAGGTAATTTACTACACTTATAAAATAGTGTGACTTTTGTGAAAATTTTGAATTAGCTTTCATATGAAGTGCCTTAAGTAGACTCTTCATTTACTTTTCTGGTAATGGTTTAAATATCATTTGTTATGC
ATTTTTAAGATACAGTTCAGAATGACACATTGTAGTGGCAAAGATAACCAAATGTCTGGCTGTTTGCTTTTTGACCATATCAATAAACTTTTACAATCTAAA

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for MAN1A1_MAGT1

In-frame Fusion Protein Sequences.

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392 length=387nt
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368468_ENST00000358075_119611847_77086392 length=419nt
MVPIPALAMTLAASSQRSQIIRSKFRSVLQLRIHRRNQEQISDPDPWISASDPPLAPALPSGTAPFLFSPGVLLPEPEYCPPWRSPKKESPKISQRWRESKPRGNLTYHQYMPPEPRQGSRADPQAEGSALGPPGPSLWEGTDSQQPHPR
MKPSPLTPCPPGVPSPSPPPHKLELQTLKLEELTVSELRQQLRLRGLPVSGTKSMLLERMRGGAPPRERPKPRREDSPAGAPWPRLKPKALAAARRQGSVKPSAASHRPPLPRAADTPGTAPAPTPTPAPAAAPALTPSSGPGSAALTLE
EELQEAIRRAQLLPNRGIDDILEDQVEPDGVCGDWKNHFTVAQSEAFDRAYRKQMRGMPTFPWDEDPEEDGSPDPEPSPEPEPKPSLEPNTSLEREPRPNSSPSPSPGQASETPHPRPS

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for MAN1A1_MAGT1

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.D112H_387_D200H length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGHPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.F48C_387_F136C length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVCSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.Q161K_387_Q249K length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDKLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.R37L_387_R125L length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALLLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.Q81H_387_Q169H length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALHPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.E126G_387_E214G length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRGNHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.W215R_387_W303R length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YARGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.A122D;p.A135D;p.T138N_387_A210D;A223D;T226N length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLDRIRENHERALREDKENLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.E280K_387_E368K length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFKVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.E259Q_387_E347Q length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEQAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.E137K_387_E225K length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKKTLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.E219K_387_E307K length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNKLKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.D243Y;p.D269Y_387_D331Y;D357Y length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVYALDTLFIMEMKHEFEEAKSWVEENLYFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.L295R_387_L383R length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYRSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.V242A_387_V330A length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIADALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.R105H_387_R193H length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRHEEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.K204R_387_K292R length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMRHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.Q159R_387_Q247R length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVARDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.W207R_387_W295R length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHARNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.D269Y_387_D357Y length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLYFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.N218H_387_N306H length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLHELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.L117P_387_L205P length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAAPEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.P179Q_387_P267Q length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPQIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.G111V_387_G199V length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPVDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.F168L;p.G297E_387_F256L;G385E length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPLRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSEEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.I180F_387_I268F length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPFGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.G108E_387_G196E length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEEAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.K156M_387_K244M length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKMVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.D189V_387_D277V length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPAVAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.E126K_387_E214K length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRKNHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.R169T_387_R257T length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFTGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.A190V_387_A278V length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADVAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.K254Q_387_K342Q length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMQHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.E183G_387_E271G length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVGSREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.E107D_387_E195D length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREDGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.S184N_387_S272N length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVENREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.E256K_387_E344K length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHKFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.E275K_387_E363K length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAKISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.E280K_387_E368K length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFKVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.E252K;p.L268V_387_E340K;L356V length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMKMKHEFEEAKSWVEENVDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.G57W_387_G145W length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFWAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.L62M_387_L150M length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFM
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.P179T_387_P267T length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPTIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.A58T_387_A146T length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGTIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.G238R_387_G326R length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKRATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.R193L_387_R281L length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAILEKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.D246Y_387_D334Y length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALYTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

>MAN1A1_MAGT1_ENST00000368466_ENST00000358075_119611847_77086392_5-gene_p.D269N_387_D357N length=387AA
MTSLPPTLRPSCPEGLQPAVCRACLCARGAAPGRRPGAELFPQGGSAAQPRGSGGLATQDPAPQPRTPSGGEVWLLSGAAPDHWTAGAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFL
PDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKG
YAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLNFNVNAEISVFEVNIRFVGGLLSAYYLSGEE

Fusion Protein ID	Sample ID	Mutated Partner	AAchange in WT	Seq. Length	AAchange in Fusion
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-19-2620-01A	5-gene	p.D112H	387	D200H
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-19-5956-01A	5-gene	p.F48C	387	F136C
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-33-4586-01A	5-gene	p.Q161K	387	Q249K
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-55-7995-01A	5-gene	p.R37L	387	R125L
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-63-A5MW-01A	5-gene	p.Q81H	387	Q169H
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-77-8139-01A	5-gene	p.E126G	387	E214G
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-77-8154-01A	5-gene	p.W215R	387	W303R
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-A5-A0G1-01A	5-gene	p.A122D;p.A135D;p.T138N	387	A210D;A223D;T226N
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-A7-A56D-01A	5-gene	p.E280K	387	E368K
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-AA-3955-01A	5-gene	p.E259Q	387	E347Q
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-AD-6895-01A	5-gene	p.E137K	387	E225K
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-AN-A046-01A	5-gene	p.E219K	387	E307K
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-B5-A1MR-01A	5-gene	p.D243Y;p.D269Y	387	D331Y;D357Y
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-BF-A1Q0-01A	5-gene	p.L295R	387	L383R
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-BK-A6W3-01A	5-gene	p.V242A	387	V330A
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-BR-8081-01A	5-gene	p.R105H	387	R193H
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-BS-A0UJ-01A	5-gene	p.K204R	387	K292R
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-BT-A3PK-01A	5-gene	p.Q159R	387	Q247R
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-CA-6717-01A	5-gene	p.W207R	387	W295R
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-D1-A103-01A	5-gene	p.D269Y	387	D357Y
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-D1-A16I-01A	5-gene	p.N218H	387	N306H
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-D1-A17Q-01A	5-gene	p.L117P	387	L205P
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-D3-A2J6-06A	5-gene	p.P179Q	387	P267Q
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-D3-A2JG-06A	5-gene	p.G111V	387	G199V
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-D3-A8GI-06A	5-gene	p.F168L;p.G297E	387	F256L;G385E
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-D3-A8GK-06A	5-gene	p.I180F	387	I268F
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-D3-A8GQ-06A	5-gene	p.G108E	387	G196E
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-D6-6823-01A	5-gene	p.K156M	387	K244M
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-DD-AACI-01A	5-gene	p.D189V	387	D277V
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-DK-A1AC-01A	5-gene	p.E126K	387	E214K
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-DK-A3WW-01A	5-gene	p.R169T	387	R257T
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-DU-6392-01A	5-gene	p.A190V	387	A278V
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-DV-5566-01A	5-gene	p.K254Q	387	K342Q
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-E6-A1LX-01A	5-gene	p.E183G	387	E271G
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-EE-A2M7-06A	5-gene	p.E107D	387	E195D
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-EE-A3J4-06A	5-gene	p.S184N	387	S272N
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-EE-A3J5-06A	5-gene	p.E256K	387	E344K
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-EE-A3JD-06A	5-gene	p.E275K	387	E363K
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-EJ-7794-01A	5-gene	p.E280K	387	E368K
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-EO-A3B0-01A	5-gene	p.E252K;p.L268V	387	E340K;L356V
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-ER-A19C-06A	5-gene	p.G57W	387	G145W
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-ER-A19P-06A	5-gene	p.L62M	387	L150M
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-ER-A19Q-06A	5-gene	p.P179T	387	P267T
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-F4-6570-01A	5-gene	p.A58T	387	A146T
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-FW-A3R5-06A	5-gene	p.G238R	387	G326R
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-HF-A5NB-01A	5-gene	p.R193L	387	R281L
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-JY-A6F8-01A	5-gene	p.D246Y	387	D334Y
ENST00000368466_ENST00000358075_119611847_77086392	TCGA-RP-A694-06A	5-gene	p.D269N	387	D357N

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for MAN1A1_MAGT1

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		SARC	TCGA-DX-AB2F-01A	MAN1A1	chr6	119611847	-	MAGT1	chrX	77086392	-
WashU		SARC	TCGA-DX-AB2F-01A	MAN1A1	chr6	119611848	-	MAGT1	chrX	77086392	-
cBioPortal	SARC_TCGA_PAN_CAN_ATLAS_2018	SOFT_TISSUE	TCGA-DX-AB2F-01	MAN1A1	chr6	119290683		MAGT1	chrX	77830895

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for MAN1A1_MAGT1

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status