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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene Breakpoints

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness

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Fusion Genomic Features

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Fusion Gene ORF Annotations

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Fusion Protein Retained/Non-Retained Functional Features

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Fusion Transcript Sequences

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Fusion Protein Sequences

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Personalized Fusion Protein Sequences

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Fusion Gene Expressed Samples

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Related Drugs

Fusion gene:LUC7L3_SPATA20 (FusionGDB2 ID:HG51747TG64847)

Fusion Gene Summary for LUC7L3_SPATA20

check button Fusion gene summary
Fusion gene informationFusion gene name: LUC7L3_SPATA20
Fusion gene ID: hg51747tg64847
HgeneTgene
Gene symbol

LUC7L3

SPATA20

Gene ID

51747

64847

Gene nameLUC7 like 3 pre-mRNA splicing factorspermatogenesis associated 20
SynonymsCRA|CREAP-1|CROP|LUC7A|OA48-18|hLuc7AHEL-S-98|SSP411|Tisp78
Cytomap

17q21.33

17q21.33

Type of geneprotein-codingprotein-coding
Descriptionluc7-like protein 3CRE-associated protein 1LUC7-like 3cAMP regulatory element-associated protein 1cisplatin resistance-associated-overexpressed proteinokadaic acid-inducible phosphoprotein OA48-18spermatogenesis-associated protein 20epididymis secretory protein Li 98sperm protein SSP411sperm-specific protein 411transcript increased in spermiogenesis 78
Modification date2024040720240305
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000240304, ENST00000311571, 
ENST00000393227, ENST00000505658, 
ENST00000544170, ENST00000503798, 
Fusion gene scores* DoF score* DoF score (Degree of Frequency) = # partners X # break points X # disease types
21 X 11 X 9=2079		* DoF score (Degree of Frequency) = # partners X # break points X # disease types
1 X 6 X 4=24
# samples 27726
** MAII score** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)
log2(2772/2079*10)=3.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)
log2(6/24*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LUC7L3 [Title/Abstract] AND SPATA20 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLUC7L3(48797192)-SPATA20(48631611), # samples:1


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Fusion Gene Breakpoints for LUC7L3_SPATA20


check button RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.
HgeneHchrHbpTgeneTchrTbp
LUC7L3chr1748797192SPATA20chr1748624429
LUC7L3chr1748797192SPATA20chr1748797192
LUC7L3chr1748797192SPATA20chr1748631612
LUC7L3chr1750719831SPATA20chr1750554251


check button DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.
HgeneHchrHbpTgeneTchrTbpSV type


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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for LUC7L3_SPATA20


check button To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.
* We have 10 tumorigenic mechanism categories of fusion genes as shown below.
Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand FusionsAberrant Chimeric Transcription Factor / Fusion Transcription Factor ActivityEpigenetic Reprogramming / Histone Modifier DysregulationChromatin Remodeling DysregulationCondensate-Driven Transcriptional Rewiring / LLPPromoter / Enhancer HijackingDominant-Negative AntagonismCell Cycle / Checkpoint Bypass / RNA Processing DysregulationSubcellular Mislocalization / Spatial DysregulationNuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.
Fusion Gene NameMechanism CategoryMechanism PubMedTumorigenic ScenariosTumorigenic Scenario PubMedTargeting PointsTargeting PubMedMechanism BackgroundMechanism Background PubMed

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.
Fusion Gene NameMechanism CategoryMechanism PubMedTumorigenic ScenariosTumorigenic Scenario PubMedTargeting PointsTargeting PubMedMechanism BackgroundMechanism Background PubMed

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

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Fusion Genomic Features for LUC7L3_SPATA20


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LUC7L3chr1748797192+SPATA20chr1748631611+2.43e-091.00e+00


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LUC7L3chr1748797192+SPATA20chr1748631611+2.43e-091.00e+00

check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).
genomic feature

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Fusion Gene ORF Annotations for LUC7L3_SPATA20

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000240304ENST00000511937LUC7L3chr17

48797192

+SPATA20chr17

48631611

+
5CDS-3UTRENST00000311571ENST00000511937LUC7L3chr17

48797192

+SPATA20chr17

48631611

+
5CDS-3UTRENST00000393227ENST00000511937LUC7L3chr17

48797192

+SPATA20chr17

48631611

+
5CDS-3UTRENST00000505658ENST00000511937LUC7L3chr17

48797192

+SPATA20chr17

48631611

+
5UTR-3CDSENST00000544170ENST00000006658LUC7L3chr17

48797192

+SPATA20chr17

48631611

+
5UTR-3CDSENST00000544170ENST00000356488LUC7L3chr17

48797192

+SPATA20chr17

48631611

+
5UTR-3CDSENST00000544170ENST00000393244LUC7L3chr17

48797192

+SPATA20chr17

48631611

+
5UTR-3UTRENST00000544170ENST00000511937LUC7L3chr17

48797192

+SPATA20chr17

48631611

+
Frame-shiftENST00000240304ENST00000006658LUC7L3chr17

48797192

+SPATA20chr17

48631611

+
Frame-shiftENST00000240304ENST00000356488LUC7L3chr17

48797192

+SPATA20chr17

48631611

+
Frame-shiftENST00000240304ENST00000393244LUC7L3chr17

48797192

+SPATA20chr17

48631611

+
Frame-shiftENST00000311571ENST00000006658LUC7L3chr17

48797192

+SPATA20chr17

48631611

+
Frame-shiftENST00000311571ENST00000356488LUC7L3chr17

48797192

+SPATA20chr17

48631611

+
Frame-shiftENST00000311571ENST00000393244LUC7L3chr17

48797192

+SPATA20chr17

48631611

+
Frame-shiftENST00000393227ENST00000006658LUC7L3chr17

48797192

+SPATA20chr17

48631611

+
Frame-shiftENST00000393227ENST00000356488LUC7L3chr17

48797192

+SPATA20chr17

48631611

+
Frame-shiftENST00000393227ENST00000393244LUC7L3chr17

48797192

+SPATA20chr17

48631611

+
Frame-shiftENST00000505658ENST00000006658LUC7L3chr17

48797192

+SPATA20chr17

48631611

+
Frame-shiftENST00000505658ENST00000356488LUC7L3chr17

48797192

+SPATA20chr17

48631611

+
Frame-shiftENST00000505658ENST00000393244LUC7L3chr17

48797192

+SPATA20chr17

48631611

+

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)
ENST00000544170ENST00000006658LUC7L3chr1748797192SPATA20chr174863161101569
ENST00000544170ENST00000356488LUC7L3chr1748797192SPATA20chr17486316110452
ENST00000544170ENST00000393244LUC7L3chr1748797192SPATA20chr17486316110134

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score
ENST00000544170ENST00000006658LUC7L3chr1748797192SPATA20chr17486316110.00e+005.27e-03
ENST00000544170ENST00000356488LUC7L3chr1748797192SPATA20chr17486316110.00e+005.27e-03
ENST00000544170ENST00000393244LUC7L3chr1748797192SPATA20chr17486316110.00e+004.57e-03

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score
ENST00000240304ENST00000511937LUC7L3chr1748797192SPATA20chr17486316110.00e+001.63e-01
ENST00000311571ENST00000511937LUC7L3chr1748797192SPATA20chr17486316110.00e+001.63e-01
ENST00000393227ENST00000511937LUC7L3chr1748797192SPATA20chr17486316110.00e+001.20e-01
ENST00000505658ENST00000511937LUC7L3chr1748797192SPATA20chr17486316110.00e+002.17e-01

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Fusion Protein Retained/Non-Retained Functional Features for LUC7L3_SPATA20

check buttonProtein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.
fgviewer annotation
- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).
No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


check button - Retained PPIs in in-frame fusion.
PartnerHgeneHbpTgeneTbpENSTUniProtStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerHgeneHbpTgeneTbpENSTUniProtStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Fusion Transcript Sequence for LUC7L3_SPATA20

check button In-frame Fusion Transcript Sequences.

check button N-Truncated Transcript (5UTR-3CDS) Sequences
>LUC7L3_SPATA20_ENST00000544170_ENST00000006658_48797192_48631611 length=642nt
Breakpoint=0nt
ACCAGGATGGAGCAGAGCCCAGCGCCAATTCCGTGTCAGCCCACAACCTGCTCCGGCTGCATGGCTTCACGGGCCACAAGGACTGGATGGACAAGTGTGTGTGCCTATTGACCGCCTTTTCCGAGCGCATGCGTCGTGTCCCGGTGGCGT
TGCCCGAGATGGTCCGCGCCCTCTCAGCCCAGCAGCAGACCCTCAAGCAGATCGTGATCTGTGGAGACCGTCAGGCCAAGGACACCAAGGCCCTGGTGCAGTGCGTCCACTCTGTCTACATTCCTAACAAGGTGCTGATTCTGGCTGATG
GGGACCCCTCGAGCTTCCTGTCCCGCCAGCTGCCTTTCCTGAGTACCCTCCGACGGTTGGAAGACCAGGCCACTGCATATGTGTGTGAGAATCAAGCCTGCTCAGTGCCCATCACTGATCCCTGCGAATTACGAAAACTACTACATCCAT
GACTGCCCCAACCCCCTTGGGGTGGGGCAGAAGGTGAAGCATCCCAACTGACTAGAGACTCAGGCCCTGCAGGGCCCTATAGAACCTGTGGCCATCCCTGAGCACCCTGCCACCAGGTGACCTCGGCCATACTCACTGCCCCCCTTGGGC
ACCCACTCACCCTAGAATAAACTTAACAGTGTCCCGTGGTAA

>LUC7L3_SPATA20_ENST00000544170_ENST00000356488_48797192_48631611 length=642nt
Breakpoint=0nt
ACCAGGATGGAGCAGAGCCCAGCGCCAATTCCGTGTCAGCCCACAACCTGCTCCGGCTGCATGGCTTCACGGGCCACAAGGACTGGATGGACAAGTGTGTGTGCCTATTGACCGCCTTTTCCGAGCGCATGCGTCGTGTCCCGGTGGCGT
TGCCCGAGATGGTCCGCGCCCTCTCAGCCCAGCAGCAGACCCTCAAGCAGATCGTGATCTGTGGAGACCGTCAGGCCAAGGACACCAAGGCCCTGGTGCAGTGCGTCCACTCTGTCTACATTCCTAACAAGGTGCTGATTCTGGCTGATG
GGGACCCCTCGAGCTTCCTGTCCCGCCAGCTGCCTTTCCTGAGTACCCTCCGACGGTTGGAAGACCAGGCCACTGCATATGTGTGTGAGAATCAAGCCTGCTCAGTGCCCATCACTGATCCCTGCGAATTACGAAAACTACTACATCCAT
GACTGCCCCAACCCCCTTGGGGTGGGGCAGAAGGTGAAGCATCCCAACTGACTAGAGACTCAGGCCCTGCAGGGCCCTATAGAACCTGTGGCCATCCCTGAGCACCCTGCCACCAGGTGACCTCGGCCATACTCACTGCCCCCCTTGGGC
ACCCACTCACCCTAGAATAAACTTAACAGTGTCCCGTGGTAA

>LUC7L3_SPATA20_ENST00000544170_ENST00000393244_48797192_48631611 length=640nt
Breakpoint=0nt
ACCAGGATGGAGCAGAGCCCAGCGCCAATTCCGTGTCAGCCCACAACCTGCTCCGGCTGCATGGCTTCACGGGCCACAAGGACTGGATGGACAAGTGTGTGTGCCTATTGACCGCCTTTTCCGAGCGCATGCGTCGTGTCCCGGTGGCGT
TGCCCGAGATGGTCCGCGCCCTCTCAGCCCAGCAGCAGACCCTCAAGCAGATCGTGATCTGTGGAGACCGTCAGGCCAAGGACACCAAGGCCCTGGTGCAGTGCGTCCACTCTGTCTACATTCCTAACAAGGTGCTGATTCTGGCTGATG
GGGACCCCTCGAGCTTCCTGTCCCGCCAGCTGCCTTTCCTGAGTACCCTCCGACGGTTGGAAGACCAGGCCACTGCATATGTGTGTGAGAATCAAGCCTGCTCAGTGCCCATCACTGATCCCTGCGAATTACGAAAACTACTACATCCAT
GACTGCCCCAACCCCCTTGGGGTGGGGCAGAAGGTGAAGCATCCCAACTGACTAGAGACTCAGGCCCTGCAGGGCCCTATAGAACCTGTGGCCATCCCTGAGCACCCTGCCACCAGGTGACCTCGGCCATACTCACTGCCCCCCTTGGGC
ACCCACTCACCCTAGAATAAACTTAACAGTGTCCCGTGGT


check button C-Truncated Transcript (5CDS-3UTR) Sequences
>LUC7L3_SPATA20_ENST00000240304_ENST00000511937_48797192_48631611 length=229nt
Breakpoint=229nt
GTCTTGTCGGCTCCTGTGTGTAGGAGGGATTTCGGCCTGAGAGCGGGCCGAGGAGATTGGCGACGGTGTCGCCCGTGTTTTCGTTGGCGGGTGCCTGGGCTGGTGGGAACAGCCGCCCGAAGGAAGCACCATGATTTCGGCCGCGCAGTT
GTTGGATGAGTTAATGGGCCGGGACCGAAACCTAGCCCCGGACGAGAAGCGCAGCAACGTGCGGTGGGACCACGAGAGC

>LUC7L3_SPATA20_ENST00000311571_ENST00000511937_48797192_48631611 length=229nt
Breakpoint=229nt
GTCTTGTCGGCTCCTGTGTGTAGGAGGGATTTCGGCCTGAGAGCGGGCCGAGGAGATTGGCGACGGTGTCGCCCGTGTTTTCGTTGGCGGGTGCCTGGGCTGGTGGGAACAGCCGCCCGAAGGAAGCACCATGATTTCGGCCGCGCAGTT
GTTGGATGAGTTAATGGGCCGGGACCGAAACCTAGCCCCGGACGAGAAGCGCAGCAACGTGCGGTGGGACCACGAGAGC

>LUC7L3_SPATA20_ENST00000393227_ENST00000511937_48797192_48631611 length=233nt
Breakpoint=233nt
TTTTGTCTTGTCGGCTCCTGTGTGTAGGAGGGATTTCGGCCTGAGAGCGGGCCGAGGAGATTGGCGACGGTGTCGCCCGTGTTTTCGTTGGCGGGTGCCTGGGCTGGTGGGAACAGCCGCCCGAAGGAAGCACCATGATTTCGGCCGCGC
AGTTGTTGGATGAGTTAATGGGCCGGGACCGAAACCTAGCCCCGGACGAGAAGCGCAGCAACGTGCGGTGGGACCACGAGAGC

>LUC7L3_SPATA20_ENST00000505658_ENST00000511937_48797192_48631611 length=288nt
Breakpoint=288nt
CTGGGCGTGTCCCACGGGCGCACGGCATGCTGGGAAGGCGTCCGCGCGGCGGCCATTTTGTCTTGTCGGCTCCTGTGTGTAGGAGGGATTTCGGCCTGAGAGCGGGCCGAGGAGATTGGCGACGGTGTCGCCCGTGTTTTCGTTGGCGGG
TGCCTGGGCTGGTGGGAACAGCCGCCCGAAGGAAGCACCATGATTTCGGCCGCGCAGTTGTTGGATGAGTTAATGGGCCGGGACCGAAACCTAGCCCCGGACGAGAAGCGCAGCAACGTGCGGTGGGACCACGAGAGC


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Fusion Protein Sequence for LUC7L3_SPATA20

check button In-frame Fusion Protein Sequences.

check button N-Truncated Protein (5UTR-3CDS) Sequences
>LUC7L3_SPATA20_ENST00000544170_ENST00000006658_48797192_48631611 length=1569nt
MIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLM
ITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCE
ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRY
TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQREL
GNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETR
YHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPN
TGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTV
PPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEET
GHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHF
HASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQE
DILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES

>LUC7L3_SPATA20_ENST00000544170_ENST00000356488_48797192_48631611 length=452nt
MKVKDEYSERDENVLKSEPMGNAEEPEIPYSYSREYNEYENIKLERHVVSFDSSRPTSGKMNCDVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHTGEKPFKCHLCNYACQRRDALTGHLRTHSVEKPYKCEFC
GRSYKQRSSLEEHKERCRTFLQSTDPGDTASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQ
ELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQNHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYEFSSHIARGEHRAL
LK

>LUC7L3_SPATA20_ENST00000544170_ENST00000393244_48797192_48631611 length=134nt
MLRLHGFTGHKDWMDKCVCLLTAFSERMRRVPVALPEMVRALSAQQQTLKQIVICGDRQAKDTKALVQCVHSVYIPNKVLILADGDPSSFLSRQLPFLSTLRRLEDQATAYVCENQACSVPITDPCELRKLLHP


check button C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for LUC7L3_SPATA20


check button TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences
NumGene GroupDomain LociFusion Protein IDFusion Gene NamePartnerMutated Residue in WT ProteinSeq. LengthMutated Residue in Fusion Protein

check button CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

NumGene GroupDomain LociFusion Protein IDFusion Gene NamePartnerMutated Residue in WT ProteinSeq. LengthMutated Residue in Fusion Protein

check button TCGA All Mutated Fusion Protein Sequences


Fusion Protein IDSample IDMutated PartnerAAchange in WTSeq. LengthAAchange in Fusion

check button CCLE All Mutated Fusion Protein Sequences


Fusion Protein IDSample IDMutated PartnerAAchange in WTSeq. LengthAAchange in Fusion

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Fusion Gene Exprssed Samples for LUC7L3_SPATA20


check buttonRNA-seq based fusion gene expressed samples.
SourceStudyDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDBLUSCTCGA-21-A5DI-01ALUC7L3

chr17

48797192+SPATA20

chr17

48624429

+
ChimerDBLUSCTCGA-21-A5DILUC7L3

chr17

48797192+SPATA20

chr17

48624429

+
ChimerDBSTADTCGA-HU-A4GH-01ALUC7L3

chr17

48797192+SPATA20

chr17

48797192

+
WashULUSCTCGA-21-A5DI-01ALUC7L3

chr17

48797192+SPATA20

chr17

48624429

+
WashUSTADTCGA-HU-A4GH-01ALUC7L3

chr17

48797192+SPATA20

chr17

48631612

+
cBioPortalSTAD_TCGA_PAN_CAN_ATLAS_2018STADTCGA-HU-A4GH-01LUC7L3

chr17

50719831SPATA20

chr17

50554251


check buttonDNA-seq based fusion gene expressed samples.
SourceStudyDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrandSV type


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Related Drugs for LUC7L3_SPATA20


check button PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.
PMIDFusion Gene NameDrugStudy Title

check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status