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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene Breakpoints

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness

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Fusion Genomic Features

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Fusion Gene ORF Annotations

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Fusion Protein Retained/Non-Retained Functional Features

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Fusion Transcript Sequences

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Fusion Protein Sequences

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Personalized Fusion Protein Sequences

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Fusion Gene Expressed Samples

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Related Drugs

Fusion gene:CSNK1G1_PPIB (FusionGDB2 ID:HG53944TG5479)

Fusion Gene Summary for CSNK1G1_PPIB

check button Fusion gene summary
Fusion gene informationFusion gene name: CSNK1G1_PPIB
Fusion gene ID: hg53944tg5479
HgeneTgene
Gene symbol

CSNK1G1

PPIB

Gene ID

53944

5479

Gene namecasein kinase 1 gamma 1peptidylprolyl isomerase B
SynonymsCK1gamma1CYP-S1|CYPB|HEL-S-39|OI9|SCYLP
Cytomap

15q22.31

15q22.31

Type of geneprotein-codingprotein-coding
Descriptioncasein kinase I isoform gamma-1peptidyl-prolyl cis-trans isomerase BPPIase BS-cyclophilincyclophilin-like proteinepididymis secretory protein Li 39peptidylprolyl isomerase B (cyclophilin B)rotamase B
Modification date2024030520240407
UniProtAcc

Q9HCP0

.
Ensembl transtripts involved in fusion geneENST00000303032, ENST00000303052, 
ENST00000607537, 		ENST00000303052, 
ENST00000607537, ENST00000303032, 
Fusion gene scores* DoF score* DoF score (Degree of Frequency) = # partners X # break points X # disease types
9 X 8 X 8=576		* DoF score (Degree of Frequency) = # partners X # break points X # disease types
3 X 7 X 5=105
# samples 2925
** MAII score** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)
log2(29/576*10)=-0.990015911427378
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)
log2(25/105*10)=1.25153876699596
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CSNK1G1 [Title/Abstract] AND PPIB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCSNK1G1(64472546)-PPIB(64454353), # samples:10

check buttonFusion gene breakpoints across CSNK1G1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PPIB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Fusion Gene Breakpoints for CSNK1G1_PPIB


check button RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.
HgeneHchrHbpTgeneTchrTbp
CSNK1G1chr1564472547PPIBchr1564454353
CSNK1G1chr1564506088PPIBchr1564448344
CSNK1G1chr1564592517PPIBchr1564449108
CSNK1G1chr1564592517PPIBchr1564452396
CSNK1G1chr1564592518PPIBchr1564449108
CSNK1G1chr1564300319PPIBchr1564156909


check button DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.
HgeneHchrHbpTgeneTchrTbpSV type


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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for CSNK1G1_PPIB


check button To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.
* We have 10 tumorigenic mechanism categories of fusion genes as shown below.
Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand FusionsAberrant Chimeric Transcription Factor / Fusion Transcription Factor ActivityEpigenetic Reprogramming / Histone Modifier DysregulationChromatin Remodeling DysregulationCondensate-Driven Transcriptional Rewiring / LLPPromoter / Enhancer HijackingDominant-Negative AntagonismCell Cycle / Checkpoint Bypass / RNA Processing DysregulationSubcellular Mislocalization / Spatial DysregulationNuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.
Fusion Gene NameMechanism CategoryMechanism PubMedTumorigenic ScenariosTumorigenic Scenario PubMedTargeting PointsTargeting PubMedMechanism BackgroundMechanism Background PubMed
CSNK1G1-PPIB
Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions
M1		Promoter swap drives cyclophilin B (PPIB) expression, accelerating protein folding in the ER and shielding cancer cells from stress.Cyclophilin inhibitors; ER stress inducersCarcinomas displaying secretory dependency

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.
Fusion Gene NameMechanism CategoryMechanism PubMedTumorigenic ScenariosTumorigenic Scenario PubMedTargeting PointsTargeting PubMedMechanism BackgroundMechanism Background PubMed
CSNK1G1-PPIB
Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions
M1		Promoter swap drives cyclophilin B (PPIB) expression, accelerating protein folding in the ER and shielding cancer cells from stress.Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 35379924; Title: 27-hydroxycholesterol linked high cholesterol diet to lung adenocarcinoma metastasis.Cyclophilin inhibitors; ER stress inducersCarcinomas displaying secretory dependency

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSNK1G1

Q9HCP0

.

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPIB

GO:0000413

protein peptidyl-prolyl isomerization

20676357

TgenePPIB

GO:0030593

neutrophil chemotaxis

11688976

TgenePPIB

GO:0061077

chaperone-mediated protein folding

22665516


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Fusion Genomic Features for CSNK1G1_PPIB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CSNK1G1chr1564472546-PPIBchr1564454353-8.21e-051.00e+00
CSNK1G1chr1564506088-PPIBchr1564448344-1.39e-091.00e+00
CSNK1G1chr1564592517-PPIBchr1564449108-8.98e-101.00e+00
CSNK1G1chr1564592517-PPIBchr1564452396-1.88e-071.00e+00


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).
genomic feature

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Fusion Gene ORF Annotations for CSNK1G1_PPIB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000303032ENST00000558492CSNK1G1chr15

64592517

-PPIBchr15

64449108

-
5CDS-5UTRENST00000303032ENST00000558492CSNK1G1chr15

64592517

-PPIBchr15

64452396

-
5CDS-5UTRENST00000303052ENST00000558492CSNK1G1chr15

64592517

-PPIBchr15

64449108

-
5CDS-5UTRENST00000303052ENST00000558492CSNK1G1chr15

64592517

-PPIBchr15

64452396

-
5CDS-5UTRENST00000607537ENST00000558492CSNK1G1chr15

64592517

-PPIBchr15

64449108

-
5CDS-5UTRENST00000607537ENST00000558492CSNK1G1chr15

64592517

-PPIBchr15

64452396

-
Frame-shiftENST00000303032ENST00000300026CSNK1G1chr15

64506088

-PPIBchr15

64448344

-
Frame-shiftENST00000303032ENST00000300026CSNK1G1chr15

64592517

-PPIBchr15

64449108

-
Frame-shiftENST00000303052ENST00000300026CSNK1G1chr15

64472546

-PPIBchr15

64454353

-
Frame-shiftENST00000303052ENST00000300026CSNK1G1chr15

64506088

-PPIBchr15

64448344

-
Frame-shiftENST00000303052ENST00000300026CSNK1G1chr15

64592517

-PPIBchr15

64449108

-
Frame-shiftENST00000607537ENST00000300026CSNK1G1chr15

64472546

-PPIBchr15

64454353

-
Frame-shiftENST00000607537ENST00000300026CSNK1G1chr15

64506088

-PPIBchr15

64448344

-
Frame-shiftENST00000607537ENST00000300026CSNK1G1chr15

64592517

-PPIBchr15

64449108

-
In-frameENST00000303032ENST00000300026CSNK1G1chr15

64592517

-PPIBchr15

64452396

-
In-frameENST00000303052ENST00000300026CSNK1G1chr15

64592517

-PPIBchr15

64452396

-
In-frameENST00000607537ENST00000300026CSNK1G1chr15

64592517

-PPIBchr15

64452396

-

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)
ENST00000303032ENST00000300026CSNK1G1chr1564592517PPIBchr1564452396661116
ENST00000303052ENST00000300026CSNK1G1chr1564592517PPIBchr1564452396605156
ENST00000607537ENST00000300026CSNK1G1chr1564592517PPIBchr1564452396591116

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score
ENST00000303032ENST00000300026CSNK1G1chr1564592517PPIBchr15644523962.20e-029.78e-01
ENST00000303052ENST00000300026CSNK1G1chr1564592517PPIBchr15644523961.60e-029.84e-01
ENST00000607537ENST00000300026CSNK1G1chr1564592517PPIBchr15644523961.70e-029.83e-01

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score

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Fusion Protein Retained/Non-Retained Functional Features for CSNK1G1_PPIB

check buttonProtein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.
fgviewer annotation
- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).
CSNK1G1_PPIB_chr15-64592517_chr15-64452396.png
CSNK1G1_PPIB_chr15-64592517_chr15-64452396.png

- In-frame and retained protein feature among the 13 regional features (texts).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCSNK1G1chr15:64592517chr15:64452396ENST00000303032Q9HCP02111_1360.333333333333336394.0Compositional biasBasic and acidic residues
HgeneCSNK1G1chr15:64592517chr15:64452396ENST00000303032Q9HCP02111_3660.333333333333336394.0RegionDisordered
TgenePPIBchr15:64592517chr15:64452396ENST00000300026P2328415213_21683.0217.0MotifNote=Prevents secretion from ER

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCSNK1G1chr15:64592517chr15:64452396ENST00000303032Q9HCP0211351_36060.333333333333336394.0Compositional biasBasic and acidic residues
HgeneCSNK1G1chr15:64592517chr15:64452396ENST00000303032Q9HCP0211361_37760.333333333333336394.0Compositional biasPolar residues
HgeneCSNK1G1chr15:64592517chr15:64452396ENST00000303032Q9HCP021144_31560.333333333333336394.0DomainProtein kinase
HgeneCSNK1G1chr15:64592517chr15:64452396ENST00000303032Q9HCP0211351_38960.333333333333336394.0RegionDisordered
TgenePPIBchr15:64592517chr15:64452396ENST00000300026P232841547_20483.0217.0DomainPPIase cyclophilin-type


check button - Retained PPIs in in-frame fusion.
PartnerHgeneHbpTgeneTbpENSTUniProtStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerHgeneHbpTgeneTbpENSTUniProtStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Fusion Transcript Sequence for CSNK1G1_PPIB

check button In-frame Fusion Transcript Sequences.
>CSNK1G1_PPIB_ENST00000303032_ENST00000300026_64592517_64452396 length=1274nt
Breakpoint=661nt
CTGCCCAAAGTTTGTCCTATTAGGCCCGCCAGGGTACTCTGCGACTCCGGGACGAGGGCGGGGCCGCGCTAGTGGTTCCGGTTCGGCTCCAGCCGCCCCTCGGCTCCTCGCCTTCCCCCTCCCGTCCGCCTTCTCCCCTCCCTCCCGCTC
CTGGGAAAGAGAGAAACCACCGCTGCGGGTGGGTAGAGAAGCACTTGGCGCCTCGGGGAGGGGACCGCGCCCGCCTCATTTGCGCCTTGCAGCACTGCTGGACCAGGTTACAAGATGTTCACCTAAGATTGAGACCTAGTGACTACATTT
CCTACGGGAACAAATAAATGGTTTTTCATCTCCCGGAGATACATTACAAACAAATATGGTGCTAAAAGAACTCCTTACCTTTCTCTGACTACAATTTATTTGGACATACTTTTGTATTGAAGAGAGGTATACATACTGAAGCTACTTGCT
GTACTATAGGAGACTCTGTCCTGTAGGATCATGGACCATCCTAGTAGGGAAAAGGATGAAAGACAACGGACAACTAAACCCATGGCACAAAGGAGTGCACACTGCTCTCGACCATCTGGCTCCTCATCGTCCTCTGGGGTTCTTATGGTG
GGACCCAACTTCAGGGTTGGCAAGAAGATAGGATGTGGGAACTTCGGAGAGCTCAGATTAGAAAGGATTTGGCTACAAAAACAGCAAATTCCATCGTGTAATCAAGGACTTCATGATCCAGGGCGGAGACTTCACCAGGGGAGATGGCAC
AGGAGGAAAGAGCATCTACGGTGAGCGCTTCCCCGATGAGAACTTCAAACTGAAGCACTACGGGCCTGGCTGGGTGAGCATGGCCAACGCAGGCAAAGACACCAACGGCTCCCAGTTCTTCATCACGACAGTCAAGACAGCCTGGCTAGA
TGGCAAGCATGTGGTGTTTGGCAAAGTTCTAGAGGGCATGGAGGTGGTGCGGAAGGTGGAGAGCACCAAGACAGACAGCCGGGATAAACCCCTGAAGGATGTGATCATCGCAGACTGCGGCAAGATCGAGGTGGAGAAGCCCTTTGCCAT
CGCCAAGGAGTAGGGCACAGGGACATCTTTCTTTGAGTGACCGTCTGTGCAGGCCCTGTAGTCCGCCACAGGGCTCTGAGCTGCACTGGCCCCGGTGCTGGCATCTGGTGGAGCGGACCCACTCCCCTCACATTCCACAGGCCCATGGAC
TCACTTTTGTAACAAACTCCTACCAACACTGACCAATAAAAAAAAATGTGGGTTTTTTTTTTTTTAATATATAA

>CSNK1G1_PPIB_ENST00000303052_ENST00000300026_64592517_64452396 length=1218nt
Breakpoint=605nt
GGCGGGGCCGCGCTAGTGGTTCCGGTTCGGCTCCAGCCGCCCCTCGGCTCCTCGCCTTCCCCCTCCCGTCCGCCTTCTCCCCTCCCTCCCGCTCCTGGGAAAGAGAGAAACCACCGCTGCGGGTGGGTAGAGAAGCACTTGGCGCCTCGG
GGAGGGGACCGCGCCCGCCTCATTTGCGCCTTGCAGCACTGCTGGACCAGGTTACAAGATGTTCACCTAAGATTGAGACCTAGTGACTACATTTCCTACGGGAACAAATAAATGGTTTTTCATCTCCCGGAGATACATTACAAACAAATA
TGGTGCTAAAAGAACTCCTTACCTTTCTCTGACTACAATTTATTTGGACATACTTTTGTATTGAAGAGAGGTATACATACTGAAGCTACTTGCTGTACTATAGGAGACTCTGTCCTGTAGGATCATGGACCATCCTAGTAGGGAAAAGGA
TGAAAGACAACGGACAACTAAACCCATGGCACAAAGGAGTGCACACTGCTCTCGACCATCTGGCTCCTCATCGTCCTCTGGGGTTCTTATGGTGGGACCCAACTTCAGGGTTGGCAAGAAGATAGGATGTGGGAACTTCGGAGAGCTCAG
ATTAGAAAGGATTTGGCTACAAAAACAGCAAATTCCATCGTGTAATCAAGGACTTCATGATCCAGGGCGGAGACTTCACCAGGGGAGATGGCACAGGAGGAAAGAGCATCTACGGTGAGCGCTTCCCCGATGAGAACTTCAAACTGAAGC
ACTACGGGCCTGGCTGGGTGAGCATGGCCAACGCAGGCAAAGACACCAACGGCTCCCAGTTCTTCATCACGACAGTCAAGACAGCCTGGCTAGATGGCAAGCATGTGGTGTTTGGCAAAGTTCTAGAGGGCATGGAGGTGGTGCGGAAGG
TGGAGAGCACCAAGACAGACAGCCGGGATAAACCCCTGAAGGATGTGATCATCGCAGACTGCGGCAAGATCGAGGTGGAGAAGCCCTTTGCCATCGCCAAGGAGTAGGGCACAGGGACATCTTTCTTTGAGTGACCGTCTGTGCAGGCCC
TGTAGTCCGCCACAGGGCTCTGAGCTGCACTGGCCCCGGTGCTGGCATCTGGTGGAGCGGACCCACTCCCCTCACATTCCACAGGCCCATGGACTCACTTTTGTAACAAACTCCTACCAACACTGACCAATAAAAAAAAATGTGGGTTTT
TTTTTTTTTAATATATAA

>CSNK1G1_PPIB_ENST00000607537_ENST00000300026_64592517_64452396 length=1204nt
Breakpoint=591nt
AGTGGTTCCGGTTCGGCTCCAGCCGCCCCTCGGCTCCTCGCCTTCCCCCTCCCGTCCGCCTTCTCCCCTCCCTCCCGCTCCTGGGAAAGAGAGAAACCACCGCTGCGGGTGGGTAGAGAAGCACTTGGCGCCTCGGGGAGGGGACCGCGC
CCGCCTCATTTGCGCCTTGCAGCACTGCTGGACCAGGTTACAAGATGTTCACCTAAGATTGAGACCTAGTGACTACATTTCCTACGGGAACAAATAAATGGTTTTTCATCTCCCGGAGATACATTACAAACAAATATGGTGCTAAAAGAA
CTCCTTACCTTTCTCTGACTACAATTTATTTGGACATACTTTTGTATTGAAGAGAGGTATACATACTGAAGCTACTTGCTGTACTATAGGAGACTCTGTCCTGTAGGATCATGGACCATCCTAGTAGGGAAAAGGATGAAAGACAACGGA
CAACTAAACCCATGGCACAAAGGAGTGCACACTGCTCTCGACCATCTGGCTCCTCATCGTCCTCTGGGGTTCTTATGGTGGGACCCAACTTCAGGGTTGGCAAGAAGATAGGATGTGGGAACTTCGGAGAGCTCAGATTAGAAAGGATTT
GGCTACAAAAACAGCAAATTCCATCGTGTAATCAAGGACTTCATGATCCAGGGCGGAGACTTCACCAGGGGAGATGGCACAGGAGGAAAGAGCATCTACGGTGAGCGCTTCCCCGATGAGAACTTCAAACTGAAGCACTACGGGCCTGGC
TGGGTGAGCATGGCCAACGCAGGCAAAGACACCAACGGCTCCCAGTTCTTCATCACGACAGTCAAGACAGCCTGGCTAGATGGCAAGCATGTGGTGTTTGGCAAAGTTCTAGAGGGCATGGAGGTGGTGCGGAAGGTGGAGAGCACCAAG
ACAGACAGCCGGGATAAACCCCTGAAGGATGTGATCATCGCAGACTGCGGCAAGATCGAGGTGGAGAAGCCCTTTGCCATCGCCAAGGAGTAGGGCACAGGGACATCTTTCTTTGAGTGACCGTCTGTGCAGGCCCTGTAGTCCGCCACA
GGGCTCTGAGCTGCACTGGCCCCGGTGCTGGCATCTGGTGGAGCGGACCCACTCCCCTCACATTCCACAGGCCCATGGACTCACTTTTGTAACAAACTCCTACCAACACTGACCAATAAAAAAAAATGTGGGTTTTTTTTTTTTTAATAT
ATAA


check button N-Truncated Transcript (5UTR-3CDS) Sequences

check button C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for CSNK1G1_PPIB

check button In-frame Fusion Protein Sequences.
>CSNK1G1_PPIB_ENST00000303032_ENST00000300026_64592517_64452396 length=116nt
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000303052_ENST00000300026_64592517_64452396 length=156nt
MPPSGSPVPSSRKGSLPRNHFEGAEAKKPRCSQRRRQLSLVTWAPQAATPEARGASRSPTEPARRPEGANLSSPKFPHPIFLPTLKLGPTIRTPEDDEEPDGREQCALLCAMGLVVRCLSSFSLLGWSMILQDRVSYSTASSFSMYTSLQ
YKSMSK

>CSNK1G1_PPIB_ENST00000607537_ENST00000300026_64592517_64452396 length=116nt
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE


check button N-Truncated Protein (5UTR-3CDS) Sequences

check button C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for CSNK1G1_PPIB


check button TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences
NumGene GroupDomain LociFusion Protein IDFusion Gene NamePartnerMutated Residue in WT ProteinSeq. LengthMutated Residue in Fusion Protein

check button CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

NumGene GroupDomain LociFusion Protein IDFusion Gene NamePartnerMutated Residue in WT ProteinSeq. LengthMutated Residue in Fusion Protein

check button TCGA All Mutated Fusion Protein Sequences
>CSNK1G1_PPIB_ENST00000303032_ENST00000300026_64592517_64452396_3-gene_p.G134W_116_G34W length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYWPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000303032_ENST00000300026_64592517_64452396_3-gene_p.V157I_116_V57I length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTIKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000303032_ENST00000300026_64592517_64452396_3-gene_p.H132Y_116_H32Y length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKYYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000303032_ENST00000300026_64592517_64452396_3-gene_p.A214T_116_A114T length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAITKE

>CSNK1G1_PPIB_ENST00000303032_ENST00000300026_64592517_64452396_3-gene_p.T113A_116_T13A length=116AA
MIQGGDFTRGDGAGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000303032_ENST00000300026_64592517_64452396_3-gene_p.C202Y_116_C102Y length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADYGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000303032_ENST00000300026_64592517_64452396_3-gene_p.P135L_116_P35L length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGLGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000303032_ENST00000300026_64592517_64452396_3-gene_p.R190Q_116_R90Q length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSQDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000303032_ENST00000300026_64592517_64452396_3-gene_p.T155M_116_T55M length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFIMTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000303032_ENST00000300026_64592517_64452396_3-gene_p.F123L_116_F23L length=116AA
MIQGGDFTRGDGTGGKSIYGERLPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000303032_ENST00000300026_64592517_64452396_3-gene_p.T155M_116_T55M length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFIMTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000303032_ENST00000300026_64592517_64452396_3-gene_p.R122H_116_R22H length=116AA
MIQGGDFTRGDGTGGKSIYGEHFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000303032_ENST00000300026_64592517_64452396_3-gene_p.Y133C_116_Y33C length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHCGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000303032_ENST00000300026_64592517_64452396_3-gene_p.G120S_116_G20S length=116AA
MIQGGDFTRGDGTGGKSIYSERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000303032_ENST00000300026_64592517_64452396_3-gene_p.S150F_116_S50F length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGFQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000607537_ENST00000300026_64592517_64452396_3-gene_p.G134W_116_G34W length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYWPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000607537_ENST00000300026_64592517_64452396_3-gene_p.V157I_116_V57I length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTIKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000607537_ENST00000300026_64592517_64452396_3-gene_p.H132Y_116_H32Y length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKYYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000607537_ENST00000300026_64592517_64452396_3-gene_p.A214T_116_A114T length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAITKE

>CSNK1G1_PPIB_ENST00000607537_ENST00000300026_64592517_64452396_3-gene_p.T113A_116_T13A length=116AA
MIQGGDFTRGDGAGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000607537_ENST00000300026_64592517_64452396_3-gene_p.C202Y_116_C102Y length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADYGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000607537_ENST00000300026_64592517_64452396_3-gene_p.P135L_116_P35L length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGLGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000607537_ENST00000300026_64592517_64452396_3-gene_p.R190Q_116_R90Q length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSQDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000607537_ENST00000300026_64592517_64452396_3-gene_p.T155M_116_T55M length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFIMTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000607537_ENST00000300026_64592517_64452396_3-gene_p.F123L_116_F23L length=116AA
MIQGGDFTRGDGTGGKSIYGERLPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000607537_ENST00000300026_64592517_64452396_3-gene_p.T155M_116_T55M length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFIMTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000607537_ENST00000300026_64592517_64452396_3-gene_p.R122H_116_R22H length=116AA
MIQGGDFTRGDGTGGKSIYGEHFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000607537_ENST00000300026_64592517_64452396_3-gene_p.Y133C_116_Y33C length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHCGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000607537_ENST00000300026_64592517_64452396_3-gene_p.G120S_116_G20S length=116AA
MIQGGDFTRGDGTGGKSIYSERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

>CSNK1G1_PPIB_ENST00000607537_ENST00000300026_64592517_64452396_3-gene_p.S150F_116_S50F length=116AA
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGFQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE



Fusion Protein IDSample IDMutated PartnerAAchange in WTSeq. LengthAAchange in Fusion
ENST00000303032_ENST00000300026_64592517_64452396TCGA-09-1675-01B3-genep.G134W116G34W
ENST00000303032_ENST00000300026_64592517_64452396TCGA-A5-A0VP-01A3-genep.V157I116V57I
ENST00000303032_ENST00000300026_64592517_64452396TCGA-AN-A03X-01A3-genep.H132Y116H32Y
ENST00000303032_ENST00000300026_64592517_64452396TCGA-AX-A1CE-01A3-genep.A214T116A114T
ENST00000303032_ENST00000300026_64592517_64452396TCGA-AX-A2HJ-01A3-genep.T113A116T13A
ENST00000303032_ENST00000300026_64592517_64452396TCGA-B0-4816-01A3-genep.C202Y116C102Y
ENST00000303032_ENST00000300026_64592517_64452396TCGA-B5-A3FC-01A3-genep.P135L116P35L
ENST00000303032_ENST00000300026_64592517_64452396TCGA-BS-A0UF-01A3-genep.R190Q116R90Q
ENST00000303032_ENST00000300026_64592517_64452396TCGA-D1-A103-01A3-genep.T155M116T55M
ENST00000303032_ENST00000300026_64592517_64452396TCGA-EE-A185-06A3-genep.F123L116F23L
ENST00000303032_ENST00000300026_64592517_64452396TCGA-EO-A22U-01A3-genep.T155M116T55M
ENST00000303032_ENST00000300026_64592517_64452396TCGA-EO-A3AY-01A3-genep.R122H116R22H
ENST00000303032_ENST00000300026_64592517_64452396TCGA-F7-A624-01A3-genep.Y133C116Y33C
ENST00000303032_ENST00000300026_64592517_64452396TCGA-G4-6302-01A3-genep.G120S116G20S
ENST00000303032_ENST00000300026_64592517_64452396TCGA-YD-A9TA-06A3-genep.S150F116S50F
ENST00000607537_ENST00000300026_64592517_64452396TCGA-09-1675-01B3-genep.G134W116G34W
ENST00000607537_ENST00000300026_64592517_64452396TCGA-A5-A0VP-01A3-genep.V157I116V57I
ENST00000607537_ENST00000300026_64592517_64452396TCGA-AN-A03X-01A3-genep.H132Y116H32Y
ENST00000607537_ENST00000300026_64592517_64452396TCGA-AX-A1CE-01A3-genep.A214T116A114T
ENST00000607537_ENST00000300026_64592517_64452396TCGA-AX-A2HJ-01A3-genep.T113A116T13A
ENST00000607537_ENST00000300026_64592517_64452396TCGA-B0-4816-01A3-genep.C202Y116C102Y
ENST00000607537_ENST00000300026_64592517_64452396TCGA-B5-A3FC-01A3-genep.P135L116P35L
ENST00000607537_ENST00000300026_64592517_64452396TCGA-BS-A0UF-01A3-genep.R190Q116R90Q
ENST00000607537_ENST00000300026_64592517_64452396TCGA-D1-A103-01A3-genep.T155M116T55M
ENST00000607537_ENST00000300026_64592517_64452396TCGA-EE-A185-06A3-genep.F123L116F23L
ENST00000607537_ENST00000300026_64592517_64452396TCGA-EO-A22U-01A3-genep.T155M116T55M
ENST00000607537_ENST00000300026_64592517_64452396TCGA-EO-A3AY-01A3-genep.R122H116R22H
ENST00000607537_ENST00000300026_64592517_64452396TCGA-F7-A624-01A3-genep.Y133C116Y33C
ENST00000607537_ENST00000300026_64592517_64452396TCGA-G4-6302-01A3-genep.G120S116G20S
ENST00000607537_ENST00000300026_64592517_64452396TCGA-YD-A9TA-06A3-genep.S150F116S50F

check button CCLE All Mutated Fusion Protein Sequences


Fusion Protein IDSample IDMutated PartnerAAchange in WTSeq. LengthAAchange in Fusion

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Fusion Gene Exprssed Samples for CSNK1G1_PPIB


check buttonRNA-seq based fusion gene expressed samples.
SourceStudyDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
GTExtissueSRR1345628CSNK1G1

chr15

64472547-PPIB

chr15

64454353

-
GTExtissueSRR1347190CSNK1G1

chr15

64472547-PPIB

chr15

64454353

-
GTExtissueSRR1445087CSNK1G1

chr15

64472547-PPIB

chr15

64454353

-
GTExtissueSRR1445895CSNK1G1

chr15

64472547-PPIB

chr15

64454353

-
GTExtissueSRR1447986CSNK1G1

chr15

64472547-PPIB

chr15

64454353

-
GTExtissueSRR1499982CSNK1G1

chr15

64472547-PPIB

chr15

64454353

-
GTExtissueSRR661937CSNK1G1

chr15

64472547-PPIB

chr15

64454353

-
GTExtissueSRR810571CSNK1G1

chr15

64472547-PPIB

chr15

64454353

-
GTExtissueSRR819346CSNK1G1

chr15

64472547-PPIB

chr15

64454353

-
GTExtissueSRR820209CSNK1G1

chr15

64472547-PPIB

chr15

64454353

-
ChimerDBLUSCTCGA-56-A5DS-01ACSNK1G1

chr15

64506088-PPIB

chr15

64448344

-
ChimerDBLUSCTCGA-77-A5G7-01BCSNK1G1

chr15

64592517-PPIB

chr15

64449108

-
ChimerDBLUSCTCGA-77-A5G7CSNK1G1

chr15

64592517-PPIB

chr15

64449108

-
ChimerDBLUSCTCGA-77-A5G7CSNK1G1

chr15

64592517-PPIB

chr15

64452396

-
WashULUSCTCGA-77-A5G7-01BCSNK1G1

chr15

64592518-PPIB

chr15

64449108

-
cBioPortalLUSC_TCGA_PAN_CAN_ATLAS_2018LUSCTCGA-77-A5G7-01CSNK1G1

chr15

64300319PPIB

chr15

64156909


check buttonDNA-seq based fusion gene expressed samples.
SourceStudyDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrandSV type


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Related Drugs for CSNK1G1_PPIB


check button PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.
PMIDFusion Gene NameDrugStudy Title

check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status