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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:YTHDF1_FAM173B (FusionGDB2 ID:HG54915TG134145)

Fusion Gene Summary for YTHDF1_FAM173B

Fusion gene summary

Fusion gene information	Fusion gene name: YTHDF1_FAM173B
	Fusion gene ID: hg54915tg134145
		Hgene	Tgene
	Gene symbol	YTHDF1	FAM173B
	Gene ID	54915	134145
	Gene name	YTH N6-methyladenosine RNA binding protein F1	ATP synthase c subunit lysine N-methyltransferase
	Synonyms	C20orf21\|DF1	FAM173B\|JS-2\|hFAM173B
	Cytomap	20q13.33	5p15.2
	Type of gene	protein-coding	protein-coding
	Description	YTH domain-containing family protein 1DACA-1YTH N(6)-methyladenosine RNA binding protein 1YTH N6-methyladenosine RNA binding protein 1YTH domain family 1YTH domain family protein 1YTH domain family, member 1dermatomyositis associated with cancer pu	ATP synthase subunit C lysine N-methyltransferasefamily with sequence similarity 173 member Bprotein FAM173Bprotein N-lysine methyltransferase FAM173B
	Modification date	20240407	20240330
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000370334, ENST00000370339, ENST00000370333,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 7 X 4 X 6=168	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 1 X 3 X 3=9
	# samples	9	3
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(9/16810)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(3/910)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: YTHDF1 [Title/Abstract] AND FAM173B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	YTHDF1(61845215)-FAM173B(10227759), # samples:1

Fusion gene breakpoints across YTHDF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FAM173B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for YTHDF1_FAM173B

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
YTHDF1	chr20	61845215	FAM173B	chr5	10227759

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for YTHDF1_FAM173B

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
YTHDF1-FAM173B	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation M8		YTHDF1 m6A RNA-binding translation reader couples to FAM173B mitochondrial methyltransferase, coordinating m6A-dependent translation enhancement directly with mitochondrial stroma modification.		Translation blockers; mitochondrial modulators		Metabolically active solid tumors

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
YTHDF1-FAM173B	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation M8		YTHDF1 m6A RNA-binding translation reader couples to FAM173B mitochondrial methyltransferase, coordinating m6A-dependent translation enhancement directly with mitochondrial stroma modification.		Translation blockers; mitochondrial modulators		Metabolically active solid tumors

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	YTHDF1	GO:0034063	stress granule assembly	32451507
Hgene	YTHDF1	GO:0043488	regulation of mRNA stability	32492408
Hgene	YTHDF1	GO:0045948	positive regulation of translational initiation	32492408
Hgene	YTHDF1	GO:0045948	positive regulation of translational initiation	26046440
Hgene	YTHDF1	GO:0061157	mRNA destabilization	32492408
Hgene	YTHDF1	GO:0070925	organelle assembly	31292544
Tgene	FAM173B	GO:0018022	peptidyl-lysine methylation	29444090

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Fusion Genomic Features for YTHDF1_FAM173B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
YTHDF1	chr20	61845215	-	FAM173B	chr5	10227759	-	1.24e-07	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for YTHDF1_FAM173B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000370334	ENST00000510052	YTHDF1	chr20	61845215	-	FAM173B	chr5	10227759	-
5CDS-5UTR	ENST00000370339	ENST00000510052	YTHDF1	chr20	61845215	-	FAM173B	chr5	10227759	-
Frame-shift	ENST00000370334	ENST00000280330	YTHDF1	chr20	61845215	-	FAM173B	chr5	10227759	-
Frame-shift	ENST00000370334	ENST00000510047	YTHDF1	chr20	61845215	-	FAM173B	chr5	10227759	-
Frame-shift	ENST00000370339	ENST00000280330	YTHDF1	chr20	61845215	-	FAM173B	chr5	10227759	-
Frame-shift	ENST00000370339	ENST00000510047	YTHDF1	chr20	61845215	-	FAM173B	chr5	10227759	-
In-frame	ENST00000370334	ENST00000511437	YTHDF1	chr20	61845215	-	FAM173B	chr5	10227759	-
In-frame	ENST00000370339	ENST00000511437	YTHDF1	chr20	61845215	-	FAM173B	chr5	10227759	-

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000370334	ENST00000511437	YTHDF1	chr20	61845215	FAM173B	chr5	10227759	379	112
ENST00000370339	ENST00000511437	YTHDF1	chr20	61845215	FAM173B	chr5	10227759	474	1143

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000370334	ENST00000511437	YTHDF1	chr20	61845215	FAM173B	chr5	10227759	3.09e-02	9.69e-01
ENST00000370339	ENST00000511437	YTHDF1	chr20	61845215	FAM173B	chr5	10227759	4.26e-02	9.57e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for YTHDF1_FAM173B

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

FAM173B

chr20:61845215

chr5:10227759

ENST00000511437

Q6P4H8

56_90

165.0

234.0

Region

Required for mitochondrial location

Tgene

FAM173B

chr20:61845215

chr5:10227759

ENST00000511437

Q6P4H8

38_58

165.0

234.0

Transmembrane

Helical

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for YTHDF1_FAM173B

In-frame Fusion Transcript Sequences.

>YTHDF1_FAM173B_ENST00000370334_ENST00000511437_61845215_10227759 length=1294nt 
 Breakpoint=379nt
CCGCTGCTGTCGCCGCCGCCGCCGCCATTGGAGTCGACGCCTCCTCAGTGCGTCCGCGTCCCGGGCTCACCGCCGCTGCCGCCTCGCCAGGGGCCCGCGCGCCCAGCAGCCGCCGCCGCCGCCCGGCCGGCGCCCGGGGAATTGGCGGCG
GGGCCCGGGGCCGCGCGAGCTAGGGTGACAGGCCCGGCCTCTAGGGGAGGCCCGAGCCGGCGGGCGCCCCGGCCCCGCGTCTAGTTGTTCATGAAGCATGTCGGCCACCAGCGTGGACACCCAGAGAACAAAAGGACAAGATAATAAAGT
ACAAAATGGTTCGTTACATCAGAAGGATACAGTTCATGACAATGACTTTGAGCCCTACCTTACTGGACAGTCAAATCAGATGCTGCAGTTGGAGAAGAAACTTGAACGTGAACTTGAGGATGATGCACGAGTTATTGCTTGCCGGTTCCC
TTTCCCACATTGGACTCCAGACCACGTCACGGGGGAGGGGATAGACACAGTGTGGGCATATGATGCAAGCACTTTTAGAGGCCGTGAAAAGAGGCCCTGTACATCGATGCATTTCCAGCTGCCCATTCAAGCATAAACTTGACTGGGAGT
GTTTTTCTGAAATATTGTAGTCTTCCCTGATCTTGTAGAGACTTACAGCTGTGTCCTTAGCAAAGGAGCATAATTGTCTTTGGTTTGGAATGAGAAATTACTATTACTTTCCTTAACTGTTGGAGAAAACAAACGAAGAAAAACAGGTAG
ATTTAAAATCTGCTTTTGATGCTATTTTCTTAAAAATTGTACTTACTGCCTTTCCATGCACCTGGATGCATGAAAAGATGAATAAGTGATGGTCATGGTTATGGGTAGGAAAATAAGATGCCAATAGCTCTTCACATTATAAACAATATG
GCTTAATGCCTCGATAAGGAGAAATGATTTTTAAAGACAGTATATATTACCAACTGTTTGTAGTATCCTATAACTTTGTTCATACTTAAGTTGTATCTCTTTCCTTTTTGTACTTCATGGCAAAATTAATTTTCTAAAGGATTCAGAGAG
GCGTTTATATTTTATAACATTTATTAGAAATAATTTGTTCCACCACTAGATTACTGTATTTTATGGAATCTAAGCTGTATATGTGTACATTTGTATACATGTATGTGTAAATGTAAGCCTGACGTGGGTTCAGATTCCAGTTTTGTCATC
AGCAAGAGGCCTCGGACCCATGACTTACTGCCTCTGAGCCTTGGCTTTCTGTGTATCTCTGCCACTGGGATAATGGTACACATAACAGTGGAGT

>YTHDF1_FAM173B_ENST00000370339_ENST00000511437_61845215_10227759 length=1389nt 
 Breakpoint=474nt
CGCAGGCGCGAAGTGTGGCGGCCCGGCGCGGCGCTCCCGGCCTGCCCCGCGTGCACGCTGACGCCGCGCAGTCTCGTCCCCTGCCGCCGCCGTCGCCGCTGCTGTCGCCGCCGCCGCCGCCATTGGAGTCGACGCCTCCTCAGTGCGTCC
GCGTCCCGGGCTCACCGCCGCTGCCGCCTCGCCAGGGGCCCGCGCGCCCAGCAGCCGCCGCCGCCGCCCGGCCGGCGCCCGGGGAATTGGCGGCGGGGCCCGGGGCCGCGCGAGCTAGGGTGACAGGCCCGGCCTCTAGGGGAGGCCCGA
GCCGGCGGGCGCCCCGGCCCCGCGTCTAGTTGTTCATGAAGCATGTCGGCCACCAGCGTGGACACCCAGAGAACAAAAGGACAAGATAATAAAGTACAAAATGGTTCGTTACATCAGAAGGATACAGTTCATGACAATGACTTTGAGCCC
TACCTTACTGGACAGTCAAATCAGATGCTGCAGTTGGAGAAGAAACTTGAACGTGAACTTGAGGATGATGCACGAGTTATTGCTTGCCGGTTCCCTTTCCCACATTGGACTCCAGACCACGTCACGGGGGAGGGGATAGACACAGTGTGG
GCATATGATGCAAGCACTTTTAGAGGCCGTGAAAAGAGGCCCTGTACATCGATGCATTTCCAGCTGCCCATTCAAGCATAAACTTGACTGGGAGTGTTTTTCTGAAATATTGTAGTCTTCCCTGATCTTGTAGAGACTTACAGCTGTGTC
CTTAGCAAAGGAGCATAATTGTCTTTGGTTTGGAATGAGAAATTACTATTACTTTCCTTAACTGTTGGAGAAAACAAACGAAGAAAAACAGGTAGATTTAAAATCTGCTTTTGATGCTATTTTCTTAAAAATTGTACTTACTGCCTTTCC
ATGCACCTGGATGCATGAAAAGATGAATAAGTGATGGTCATGGTTATGGGTAGGAAAATAAGATGCCAATAGCTCTTCACATTATAAACAATATGGCTTAATGCCTCGATAAGGAGAAATGATTTTTAAAGACAGTATATATTACCAACT
GTTTGTAGTATCCTATAACTTTGTTCATACTTAAGTTGTATCTCTTTCCTTTTTGTACTTCATGGCAAAATTAATTTTCTAAAGGATTCAGAGAGGCGTTTATATTTTATAACATTTATTAGAAATAATTTGTTCCACCACTAGATTACT
GTATTTTATGGAATCTAAGCTGTATATGTGTACATTTGTATACATGTATGTGTAAATGTAAGCCTGACGTGGGTTCAGATTCCAGTTTTGTCATCAGCAAGAGGCCTCGGACCCATGACTTACTGCCTCTGAGCCTTGGCTTTCTGTGTA
TCTCTGCCACTGGGATAATGGTACACATAACAGTGGAGT

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for YTHDF1_FAM173B

In-frame Fusion Protein Sequences.

>YTHDF1_FAM173B_ENST00000370334_ENST00000511437_61845215_10227759 length=112nt
MSATSVDTQRTKGQDNKVQNGSLHQKDTVHDNDFEPYLTGQSNQMLQLEKKLERELEDDARVIACRFPFPHWTPDHVTGEGIDTVWAYDASTFRGREKRPCTSMHFQLPIQA

>YTHDF1_FAM173B_ENST00000370339_ENST00000511437_61845215_10227759 length=1143nt
MTVGRRKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAA
ARNVNPKSPITELLEQNGGYGSATLSRGPPPPVGPAGSGYSGGLALAEYDQPYGGFLDILRGGTERLFTNLKDTSSKVIQSVANYAKGDLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPRTYRPSRFHNR
VSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCFCRLFSTAEAAVYMFSMKRCPPGIWPSHKRYIEYMCDMVAEEPITPHSKPILVRAVVMTPVPLFSKQRSGCRPFCEVYVGDERVASTSQEYDKM
RDFKIEDGKAVIPLGVTVQGDVLIVIYHARSTLGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRPSREAPPWENSSMRGLNPKILFSSREEQQDILSKFGKPELPRQPGSTAQYDAGA
GSPEAEPTDSDSPPSSSADASRFLHTLDWQEEKEAETGAENASSKESESALMEDRDESEVSDEGGSPISSEGQEPRADPEPPGLAAGLVQQDLVFEVETPAVLPEPVPQEDGVDLLGLHSEVGAGPAVPPQACKAPSSNTDLLSCLLGPP
EAASQGPPEDLLSEDPLLLASPAPPLSVQSTPRGGPPAAADPFGPLLPSSGNNSQPCSNPDLFGEFLNSDSVTVPPSFPSAHSAPPPSCSADFLHLGDLPGEPSKMTASSSNPDLLGGWAAWTETAASAVAPTPATEGPLFSPGGQPAPC
GSQASWTKSQNPDPFADLGDLSSGLQGSPAGFPPGGFIPKTATTPKGSSSWQTSRPPAQGASWPPQAKPPPKACTQPRPNYASNFSVIGAREERGVRAPSFAQKPKVSENDFEDLLSNQGFSSRSDKKGPKTIAEMRKQDLAKDTDPLKL
KLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVGMADLVAPEQVKKHYRRAVLAVHPDKAAGQPYEQHAKMIFMELNDAWSEFENQGSRPLF

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for YTHDF1_FAM173B

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

>YTHDF1_FAM173B_ENST00000370334_ENST00000511437_61845215_10227759_5-gene_p.Q41H_112_Q41H length=112AA
MSATSVDTQRTKGQDNKVQNGSLHQKDTVHDNDFEPYLTGHSNQMLQLEKKLERELEDDARVIACRFPFPHWTPDHVTGEGIDTVWAYDASTFRGREKRPCTSMHFQLPIQA

>YTHDF1_FAM173B_ENST00000370334_ENST00000511437_61845215_10227759_5-gene_p.Q25H_112_Q25H length=112AA
MSATSVDTQRTKGQDNKVQNGSLHHKDTVHDNDFEPYLTGQSNQMLQLEKKLERELEDDARVIACRFPFPHWTPDHVTGEGIDTVWAYDASTFRGREKRPCTSMHFQLPIQA

>YTHDF1_FAM173B_ENST00000370334_ENST00000511437_61845215_10227759_5-gene_p.D31Y_112_D31Y length=112AA
MSATSVDTQRTKGQDNKVQNGSLHQKDTVHYNDFEPYLTGQSNQMLQLEKKLERELEDDARVIACRFPFPHWTPDHVTGEGIDTVWAYDASTFRGREKRPCTSMHFQLPIQA

>YTHDF1_FAM173B_ENST00000370334_ENST00000511437_61845215_10227759_5-gene_p.V29F_112_V29F length=112AA
MSATSVDTQRTKGQDNKVQNGSLHQKDTFHDNDFEPYLTGQSNQMLQLEKKLERELEDDARVIACRFPFPHWTPDHVTGEGIDTVWAYDASTFRGREKRPCTSMHFQLPIQA

>YTHDF1_FAM173B_ENST00000370334_ENST00000511437_61845215_10227759_5-gene_p.N16T_112_N16T length=112AA
MSATSVDTQRTKGQDTKVQNGSLHQKDTVHDNDFEPYLTGQSNQMLQLEKKLERELEDDARVIACRFPFPHWTPDHVTGEGIDTVWAYDASTFRGREKRPCTSMHFQLPIQA

Fusion Protein ID	Sample ID	Mutated Partner	AAchange in WT	Seq. Length	AAchange in Fusion
ENST00000370334_ENST00000511437_61845215_10227759	TCGA-A5-A0G2-01A	5-gene	p.Q41H	112	Q41H
ENST00000370334_ENST00000511437_61845215_10227759	TCGA-AC-A23H-01A	5-gene	p.Q25H	112	Q25H
ENST00000370334_ENST00000511437_61845215_10227759	TCGA-BS-A0UV-01A	5-gene	p.D31Y	112	D31Y
ENST00000370334_ENST00000511437_61845215_10227759	TCGA-CA-6717-01A	5-gene	p.V29F	112	V29F
ENST00000370334_ENST00000511437_61845215_10227759	TCGA-D1-A103-01A	5-gene	p.N16T	112	N16T

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for YTHDF1_FAM173B

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		STAD	TCGA-CD-8530-01A	YTHDF1	chr20	61845215	-	FAM173B	chr5	10227759	-

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for YTHDF1_FAM173B

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status