Home

Download

Statistics

Examples

About

Contact

	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:FBXO34_RALYL (FusionGDB2 ID:HG55030TG138046)

Fusion Gene Summary for FBXO34_RALYL

Fusion gene summary

Fusion gene information	Fusion gene name: FBXO34_RALYL
	Fusion gene ID: hg55030tg138046
		Hgene	Tgene
	Gene symbol	FBXO34	RALYL
	Gene ID	55030	138046
	Gene name	F-box protein 34	RALY RNA binding protein like
	Synonyms	CGI-301\|Fbx34	HNRPCL3
	Cytomap	14q22.3	8q21.2
	Type of gene	protein-coding	protein-coding
	Description	F-box only protein 34protein CGI-301	RNA-binding Raly-like proteinheterogeneous nuclear ribonucleoprotein C-like 3hnRNP core protein C-like 3
	Modification date	20240403	20240403
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000313833, ENST00000440021, ENST00000555087,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 14 X 8 X 11=1232	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 12 X 23 X 17=4692
	# samples	191	31
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(191/123210)=0.632570382228209 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(31/469210)=-3.91986289275427 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FBXO34 [Title/Abstract] AND RALYL [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FBXO34(55738255)-RALYL(85686813), # samples:1

Top

Fusion Gene Breakpoints for FBXO34_RALYL

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
FBXO34	chr14	55738255	RALYL	chr8	55738255
FBXO34	chr14	55738255	RALYL	chr8	85686814

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

Top

Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for FBXO34_RALYL

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Top

Fusion Genomic Features for FBXO34_RALYL

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
FBXO34	chr14	55738255	+	RALYL	chr8	85686813	+	3.18e-08	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
FBXO34	chr14	55738255	+	RALYL	chr8	85686813	+	3.18e-08	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

Top

Fusion Gene ORF Annotations for FBXO34_RALYL

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000313833	ENST00000517638	FBXO34	chr14	55738255	+	RALYL	chr8	85686813	+
5UTR-3CDS	ENST00000313833	ENST00000518566	FBXO34	chr14	55738255	+	RALYL	chr8	85686813	+
5UTR-3CDS	ENST00000313833	ENST00000521268	FBXO34	chr14	55738255	+	RALYL	chr8	85686813	+
5UTR-3CDS	ENST00000313833	ENST00000521376	FBXO34	chr14	55738255	+	RALYL	chr8	85686813	+
5UTR-3CDS	ENST00000313833	ENST00000521695	FBXO34	chr14	55738255	+	RALYL	chr8	85686813	+
5UTR-3CDS	ENST00000313833	ENST00000522455	FBXO34	chr14	55738255	+	RALYL	chr8	85686813	+
5UTR-3CDS	ENST00000313833	ENST00000523850	FBXO34	chr14	55738255	+	RALYL	chr8	85686813	+

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000313833	ENST00000517638	FBXO34	chr14	55738255	RALYL	chr8	85686813	0	178
ENST00000313833	ENST00000518566	FBXO34	chr14	55738255	RALYL	chr8	85686813	0	203
ENST00000313833	ENST00000521268	FBXO34	chr14	55738255	RALYL	chr8	85686813	0	192
ENST00000313833	ENST00000521376	FBXO34	chr14	55738255	RALYL	chr8	85686813	0	203
ENST00000313833	ENST00000521695	FBXO34	chr14	55738255	RALYL	chr8	85686813	0	131
ENST00000313833	ENST00000522455	FBXO34	chr14	55738255	RALYL	chr8	85686813	0	203
ENST00000313833	ENST00000523850	FBXO34	chr14	55738255	RALYL	chr8	85686813	0	203

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000313833	ENST00000517638	FBXO34	chr14	55738255	RALYL	chr8	85686813	0.00e+00	5.16e-03
ENST00000313833	ENST00000518566	FBXO34	chr14	55738255	RALYL	chr8	85686813	0.00e+00	7.19e-03
ENST00000313833	ENST00000521268	FBXO34	chr14	55738255	RALYL	chr8	85686813	0.00e+00	5.36e-03
ENST00000313833	ENST00000521376	FBXO34	chr14	55738255	RALYL	chr8	85686813	0.00e+00	7.32e-02
ENST00000313833	ENST00000521695	FBXO34	chr14	55738255	RALYL	chr8	85686813	0.00e+00	5.36e-03
ENST00000313833	ENST00000522455	FBXO34	chr14	55738255	RALYL	chr8	85686813	0.00e+00	5.03e-03
ENST00000313833	ENST00000523850	FBXO34	chr14	55738255	RALYL	chr8	85686813	0.00e+00	5.10e-03

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

Top

Fusion Protein Retained/Non-Retained Functional Features for FBXO34_RALYL

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Fusion Transcript Sequence for FBXO34_RALYL

In-frame Fusion Transcript Sequences.

N-Truncated Transcript (5UTR-3CDS) Sequences

>FBXO34_RALYL_ENST00000313833_ENST00000517638_55738255_85686813 length=1553nt 
 Breakpoint=0nt
ATATCAACATGGCAGGAGAGCCCAAACCATACAGACCAAAACCTGGAAACAAGAGGCCCCTTTCTGCACTTTACAGACTTGAATCAAAGGAACCTTTCCTGTCTGTTGGCGGTTATGTCTTTGACTATGATTACTACAGAGATGATTTCT
ACAATCGGTTATTTGATTACCACGGGCGTGTGCCTCCACCTCCCCGTGCAGTAATTCCGCTGAAGCGTCCCAGAGTGGCAGTCACAACGACTCGCAGGGGGAAAGGAGTCTTTTCCATGAAAGGTGGATCGAGATCTACTGCCAGTGGGT
CAACAGGTTCTAAATTGAAATCAGATGAGTTACAGACCATCAAGAAAGAATTAACCCAGATCAAAACTAAAATTGACTCCTTGCTAGGGCGCCTGGAGAAGATTGAGAAACAGCAGAAGGCGGAGGCAGAAGCTCAGAAGAAGCAATTGG
AAGAGAGTCTAGTGCTGATCCAAGAGGAATGTGTGTCAGAGATTGCAGATCACTCTACAGAGGAGCCTGCTGAAGGAGGGCCAGATGCCGATGGAGAAGAGATGACAGATGGGATAGAGGAGGACTTCGATGAAGATGGGGGTCATGAGC
TGTTTCTACAGATAAAGTGATCTGAAATAACGCATGATGCCACAAAGCAGAAAAGAGAAACTGTGACAACCCCCAGAAATGTGAAAGGAGGTTTCTTACTGGACAGCAGCATCTTTGGTTCAATTTATATAAAAACCCAAATAAATAAAA
TGGACAGTATTGCTCAGTTTTAGAAATTCCATTTCTTCTATGTTTTAAGCTGTACAATTGTCAGGTTTTTATGGTTTAAATTGTAAATGTGTTTTCCCCTTTGCTAATTATGTTTTTTTTTTCAGTCTTAAAATGTGAAAGGCATTTATG
AATGGTAAGGGAAACACTATATACAAATGTATATTTGTAAAAGCTATTTTTATGATTAGCATGTTTCACTGTTGATCATATATAAAGTCAGGTGATATTGCAATTCTGTATTTAAAGCTTATTTCCAACAATGTCATGTAAGAAAAGATG
CATCTTATGCTAGTTTTTATAATTTATTTATAATTTATAGTTTAAAGTACTTCAGATCATAATGATAAAATACTTGAAAAAGTTATATTTCTGCCCTGTATAAGCACCCTTTTTATTAATAAAGAATGCAGATATTTCAGATGTGATATA
ATAGTTAAAGAACTGTTGGTTTGATCTGTGATTAAGTTGAGCATGCTCCGCTCTACTGAACTAAATGATCCAATTATTACTTCAGTCTGGGTATGAGATTCCATGGACAAGTAAGGACTAGATTGCCAAGGAAAAGACTGTCTTGCCCTT
GGATCCAAAAGTTTAAATTAGTGCATACATCATGTCATTTCACCTCCTGTTCCTAGGAACTCTCCATTCCCAAGCATTGCCAGTGTTTTCCAGATAATCTTAGCTGTTGTCTTGTGCTGTGGAAATGGAAGAAACCATCTTCACAGACCG
TAGGAGAATTCAACATATAATTTCTTAATAAATACTGTTTCTTTTAAAACAAA

>FBXO34_RALYL_ENST00000313833_ENST00000518566_55738255_85686813 length=1512nt 
 Breakpoint=0nt
ATATCAACATGGCAGGAGAGCCCAAACCATACAGACCAAAACCTGGAAACAAGAGGCCCCTTTCTGCACTTTACAGCGGTTATGTCTTTGACTATGATTACTACAGAGATGATTTCTACAATCGGTTATTTGATTACCACGGGCGTGTGC
CTCCACCTCCCCGTGCAGTAATTCCGCTGAAGCGTCCCAGAGTGGCAGTCACAACGACTCGCAGGGGGAAAGGAGTCTTTTCCATGAAAGGTGGATCGAGATCTACTGCCAGTGGGTCAACAGGTTCTAAATTGAAATCAGATGAGTTAC
AGACCATCAAGAAAGAATTAACCCAGATCAAAACTAAAATTGACTCCTTGCTAGGGCGCCTGGAGAAGATTGAGAAACAGCAGAAGGCGGAGGCAGAAGCTCAGAAGAAGCAATTGGAAGAGAGTCTAGTGCTGATCCAAGAGGAATGTG
TGTCAGAGATTGCAGATCACTCTACAGAGGAGCCTGCTGAAGGAGGGCCAGATGCCGATGGAGAAGAGATGACAGATGGGATAGAGGAGGACTTCGATGAAGATGGGGGTCATGAGCTGTTTCTACAGATAAAGTGATCTGAAATAACGC
ATGATGCCACAAAGCAGAAAAGAGAAACTGTGACAACCCCCAGAAATGTGAAAGGAGGTTTCTTACTGGACAGCAGCATCTTTGGTTCAATTTATATAAAAACCCAAATAAATAAAATGGACAGTATTGCTCAGTTTTAGAAATTCCATT
TCTTCTATGTTTTAAGCTGTACAATTGTCAGGTTTTTATGGTTTAAATTGTAAATGTGTTTTCCCCTTTGCTAATTATGTTTTTTTTTTCAGTCTTAAAATGTGAAAGGCATTTATGAATGGTAAGGGAAACACTATATACAAATGTATA
TTTGTAAAAGCTATTTTTATGATTAGCATGTTTCACTGTTGATCATATATAAAGTCAGGTGATATTGCAATTCTGTATTTAAAGCTTATTTCCAACAATGTCATGTAAGAAAAGATGCATCTTATGCTAGTTTTTATAATTTATTTATAA
TTTATAGTTTAAAGTACTTCAGATCATAATGATAAAATACTTGAAAAAGTTATATTTCTGCCCTGTATAAGCACCCTTTTTATTAATAAAGAATGCAGATATTTCAGATGTGATATAATAGTTAAAGAACTGTTGGTTTGATCTGTGATT
AAGTTGAGCATGCTCCGCTCTACTGAACTAAATGATCCAATTATTACTTCAGTCTGGGTATGAGATTCCATGGACAAGTAAGGACTAGATTGCCAAGGAAAAGACTGTCTTGCCCTTGGATCCAAAAGTTTAAATTAGTGCATACATCAT
GTCATTTCACCTCCTGTTCCTAGGAACTCTCCATTCCCAAGCATTGCCAGTGTTTTCCAGATAATCTTAGCTGTTGTCTTGTGCTGTGGAAATGGAAGAAACCATCTTCACAGACCGTAGGAGAATTCAACATATAATTTCTTAATAAAT
ACTGTTTCTTTT

>FBXO34_RALYL_ENST00000313833_ENST00000521268_55738255_85686813 length=1340nt 
 Breakpoint=0nt
ATATCAACATGGCAGGAGAGCCCAAACCATACAGACCAAAACCTGGAAACAAGAGGCCCCTTTCTGCACTTTACAGACTTGAATCAAAGGAACCTTTCCTGTCTGTTGGCGGTTATGTCTTTGACTATGATTACTACAGAGATGATTTCT
ACAATCGGTTATTTGATTACCACGGGCGTGTGCCTCCACCTCCCCGTGCAGTAATTCCGCTGAAGCGTCCCAGAGTGGCAGTCACAACGACTCGCAGGGGGAAAGGAGTCTTTTCCATGAAAGGTGGATCGAGATCTACTGCCAGTGGGT
CAACAGGTTCTAAATTGAAATCAGATGAGTTACAGACCATCAAGAAAGAATTAACCCAGATCAAAACTAAAATTGACTCCTTGCTAGGGCGCCTGGAGAAGATTGAGAAACAGCAGAAGGCGGAGGCAGAAGCTCAGAAGAAGCAATTGG
AAGAGAGTCTAGTGCTGATCCAAGAGGAATGTGTGTCAGAGATTGCAGATCACTCTACAGAGGAGCCTGCTGAAGGAGGGCCAGATGCCGATGGAGAAGAGATGACAGATGGGATAGAGGAGGACTTCGATGAAGATGGGGGTCATGAGC
TGTTTCTACAGATAAAGTGATCTGAAATAACGCATGATGCCACAAAGCAGAAAAGAGAAACTGTGACAACCCCCAGAAATGTGAAAGGAGGTTTCTTACTGGACAGCAGCATCTTTGGTTCAATTTATATAAAAACCCAAATAAATAAAA
TGGACAGTATTGCTCAGTTTTAGAAATTCCATTTCTTCTATGTTTTAAGCTGTACAATTGTCAGGTTTTTATGGTTTAAATTGTAAATGTGTTTTCCCCTTTGCTAATTATGTTTTTTTTTTCAGTCTTAAAATGTGAAAGGCATTTATG
AATGGTAAGGGAAACACTATATACAAATGTATATTTGTAAAAGCTATTTTTATGATTAGCATGTTTCACTGTTGATCATATATAAAGTCAGGTGATATTGCAATTCTGTATTTAAAGCTTATTTCCAACAATGTCATGTAAGAAAAGATG
CATCTTATGCTAGTTTTTATAATTTATTTATAATTTATAGTTTAAAGTACTTCAGATCATAATGATAAAATACTTGAAAAAGTTATATTTCTGCCCTGTATAAGCACCCTTTTTATTAATAAAGAATGCAGATATTTCAGATGTGATATA
ATAGTTAAAGAACTGTTGGTTTGATCTGTGATTAAGTTGAGCATGCTCCGCTCTACTGAACTAAATGATCCAATTATTACTTCAGTCTGGGTATGAGATTCCATGGACAAGTAAGGACTAGATTGCCAAGGAAAAGACTG

>FBXO34_RALYL_ENST00000313833_ENST00000521376_55738255_85686813 length=1332nt 
 Breakpoint=0nt
ATATCAACATGGCAGGAGAGCCCAAACCATACAGACCAAAACCTGGAAACAAGAGGCCCCTTTCTGCACTTTACAGACTTGAATCAAAGGAACCTTTCCTGTCTGTTGGGTTATTTGATTACCACGGGCGTGTGCCTCCACCTCCCCGTG
CAGTAATTCCGCTGAAGCGTCCCAGAGTGGCAGTCACAACGACTCGCAGGGGGAAAGGAGTCTTTTCCATGAAAGGTGGATCGAGATCTACTGCCAGTGGGTCAACAGGTTCTAAATTGAAATCAGATGAGTTACAGACCATCAAGAAAG
AATTAACCCAGATCAAAACTAAAATTGACTCCTTGCTAGGGCGCCTGGAGAAGATTGAGAAACAGCAGAAGGCGGAGGCAGTTTCTACAGATAAAGTGATCTGAAATAACGCATGATGCCACAAAGCAGAAAAGAGAAACTGTGACAACC
CCCAGAAATGTGAAAGGAGGTTTCTTACTGGACAGCAGCATCTTTGGTTCAATTTATATAAAAACCCAAATAAATAAAATGGACAGTATTGCTCAGTTTTAGAAATTCCATTTCTTCTATGTTTTAAGCTGTACAATTGTCAGGTTTTTA
TGGTTTAAATTGTAAATGTGTTTTCCCCTTTGCTAATTATGTTTTTTTTTTCAGTCTTAAAATGTGAAAGGCATTTATGAATGGTAAGGGAAACACTATATACAAATGTATATTTGTAAAAGCTATTTTTATGATTAGCATGTTTCACTG
TTGATCATATATAAAGTCAGGTGATATTGCAATTCTGTATTTAAAGCTTATTTCCAACAATGTCATGTAAGAAAAGATGCATCTTATGCTAGTTTTTATAATTTATTTATAATTTATAGTTTAAAGTACTTCAGATCATAATGATAAAAT
ACTTGAAAAAGTTATATTTCTGCCCTGTATAAGCACCCTTTTTATTAATAAAGAATGCAGATATTTCAGATGTGATATAATAGTTAAAGAACTGTTGGTTTGATCTGTGATTAAGTTGAGCATGCTCCGCTCTACTGAACTAAATGATCC
AATTATTACTTCAGTCTGGGTATGAGATTCCATGGACAAGTAAGGACTAGATTGCCAAGGAAAAGACTGTCTTGCCCTTGGATCCAAAAGTTTAAATTAGTGCATACATCATGTCATTTCACCTCCTGTTCCTAGGAACTCTCCATTCCC
AAGCATTGCCAGTGTTTTCCAGATAATCTTAGCTGTTGTCTTGTGCTGTGGAAATGGAAGAAACCATCTTCACAGACCGTAGGAGAATTCAACATATAATTTCTTAATAAATACTGTTTCTTTTAAAACAAA

>FBXO34_RALYL_ENST00000313833_ENST00000521695_55738255_85686813 length=1340nt 
 Breakpoint=0nt
ATATCAACATGGCAGGAGAGCCCAAACCATACAGACCAAAACCTGGAAACAAGAGGCCCCTTTCTGCACTTTACAGACTTGAATCAAAGGAACCTTTCCTGTCTGTTGGCGGTTATGTCTTTGACTATGATTACTACAGAGATGATTTCT
ACAATCGGTTATTTGATTACCACGGGCGTGTGCCTCCACCTCCCCGTGCAGTAATTCCGCTGAAGCGTCCCAGAGTGGCAGTCACAACGACTCGCAGGGGGAAAGGAGTCTTTTCCATGAAAGGTGGATCGAGATCTACTGCCAGTGGGT
CAACAGGTTCTAAATTGAAATCAGATGAGTTACAGACCATCAAGAAAGAATTAACCCAGATCAAAACTAAAATTGACTCCTTGCTAGGGCGCCTGGAGAAGATTGAGAAACAGCAGAAGGCGGAGGCAGAAGCTCAGAAGAAGCAATTGG
AAGAGAGTCTAGTGCTGATCCAAGAGGAATGTGTGTCAGAGATTGCAGATCACTCTACAGAGGAGCCTGCTGAAGGAGGGCCAGATGCCGATGGAGAAGAGATGACAGATGGGATAGAGGAGGACTTCGATGAAGATGGGGGTCATGAGC
TGTTTCTACAGATAAAGTGATCTGAAATAACGCATGATGCCACAAAGCAGAAAAGAGAAACTGTGACAACCCCCAGAAATGTGAAAGGAGGTTTCTTACTGGACAGCAGCATCTTTGGTTCAATTTATATAAAAACCCAAATAAATAAAA
TGGACAGTATTGCTCAGTTTTAGAAATTCCATTTCTTCTATGTTTTAAGCTGTACAATTGTCAGGTTTTTATGGTTTAAATTGTAAATGTGTTTTCCCCTTTGCTAATTATGTTTTTTTTTTCAGTCTTAAAATGTGAAAGGCATTTATG
AATGGTAAGGGAAACACTATATACAAATGTATATTTGTAAAAGCTATTTTTATGATTAGCATGTTTCACTGTTGATCATATATAAAGTCAGGTGATATTGCAATTCTGTATTTAAAGCTTATTTCCAACAATGTCATGTAAGAAAAGATG
CATCTTATGCTAGTTTTTATAATTTATTTATAATTTATAGTTTAAAGTACTTCAGATCATAATGATAAAATACTTGAAAAAGTTATATTTCTGCCCTGTATAAGCACCCTTTTTATTAATAAAGAATGCAGATATTTCAGATGTGATATA
ATAGTTAAAGAACTGTTGGTTTGATCTGTGATTAAGTTGAGCATGCTCCGCTCTACTGAACTAAATGATCCAATTATTACTTCAGTCTGGGTATGAGATTCCATGGACAAGTAAGGACTAGATTGCCAAGGAAAAGACTG

>FBXO34_RALYL_ENST00000313833_ENST00000522455_55738255_85686813 length=1545nt 
 Breakpoint=0nt
ATATCAACATGGCAGGAGAGCCCAAACCATACAGACCAAAACCTGGAAACAAGAGGCCCCTTTCTGCACTTTACAGACTTGAATCAAAGGAACCTTTCCTGTCTGTTGGCGGTTATGTCTTTGACTATGATTACTACAGAGATGATTTCT
ACAATCGGTTATTTGATTACCACGGGCGTGTGCCTCCACCTCCCCGTGCAGTAATTCCGCTGAAGCGTCCCAGAGTGGCAGTCACAACGACTCGCAGGGGGAAAGGAGTCTTTTCCATGAAAGGTGGATCGAGATCTACTGCCAGTGGGT
CAACAGGTTCTAAATTGAAATCAGATGAGTTACAGACCATCAAGAAAGAATTAACCCAGATCAAAACTAAAATTGACTCCTTGCTAGGGCGCCTGGAGAAGATTGAGAAACAGCAGAAGGCGGAGGCAGAAGCTCAGAAGAAGCAATTGG
AAGAGAGTCTAGTGCTGATCCAAGAGGAATGTGTGTCAGAGATTGCAGATCACTCTACAGAGGAGCCTGCTGAAGGAGGGCCAGATGCCGATGGAGAAGAGATGACAGATGGGATAGAGGAGGACTTCGATGAAGATGGGGGTCATGAGC
TGTTTCTACAGATAAAGTGATCTGAAATAACGCATGATGCCACAAAGCAGAAAAGAGAAACTGTGACAACCCCCAGAAATGTGAAAGGAGGTTTCTTACTGGACAGCAGCATCTTTGGTTCAATTTATATAAAAACCCAAATAAATAAAA
TGGACAGTATTGCTCAGTTTTAGAAATTCCATTTCTTCTATGTTTTAAGCTGTACAATTGTCAGGTTTTTATGGTTTAAATTGTAAATGTGTTTTCCCCTTTGCTAATTATGTTTTTTTTTTCAGTCTTAAAATGTGAAAGGCATTTATG
AATGGTAAGGGAAACACTATATACAAATGTATATTTGTAAAAGCTATTTTTATGATTAGCATGTTTCACTGTTGATCATATATAAAGTCAGGTGATATTGCAATTCTGTATTTAAAGCTTATTTCCAACAATGTCATGTAAGAAAAGATG
CATCTTATGCTAGTTTTTATAATTTATTTATAATTTATAGTTTAAAGTACTTCAGATCATAATGATAAAATACTTGAAAAAGTTATATTTCTGCCCTGTATAAGCACCCTTTTTATTAATAAAGAATGCAGATATTTCAGATGTGATATA
ATAGTTAAAGAACTGTTGGTTTGATCTGTGATTAAGTTGAGCATGCTCCGCTCTACTGAACTAAATGATCCAATTATTACTTCAGTCTGGGTATGAGATTCCATGGACAAGTAAGGACTAGATTGCCAAGGAAAAGACTGTCTTGCCCTT
GGATCCAAAAGTTTAAATTAGTGCATACATCATGTCATTTCACCTCCTGTTCCTAGGAACTCTCCATTCCCAAGCATTGCCAGTGTTTTCCAGATAATCTTAGCTGTTGTCTTGTGCTGTGGAAATGGAAGAAACCATCTTCACAGACCG
TAGGAGAATTCAACATATAATTTCTTAATAAATACTGTTTCTTTT

>FBXO34_RALYL_ENST00000313833_ENST00000523850_55738255_85686813 length=1550nt 
 Breakpoint=0nt
ATATCAACATGGCAGGAGAGCCCAAACCATACAGACCAAAACCTGGAAACAAGAGGCCCCTTTCTGCACTTTACAGACTTGAATCAAAGGAACCTTTCCTGTCTGTTGGCGGTTATGTCTTTGACTATGATTACTACAGAGATGATTTCT
ACAATCGGTTATTTGATTACCACGGGCGTGTGCCTCCACCTCCCCGTGCAGTAATTCCGCTGAAGCGTCCCAGAGTGGCAGTCACAACGACTCGCAGGGGGAAAGGAGTCTTTTCCATGAAAGGTGGATCGAGATCTACTGCCAGTGGGT
CAACAGGTTCTAAATTGAAATCAGATGAGTTACAGACCATCAAGAAAGAATTAACCCAGATCAAAACTAAAATTGACTCCTTGCTAGGGCGCCTGGAGAAGATTGAGAAACAGCAGAAGGCGGAGGCAGAAGCTCAGAAGAAGCAATTGG
AAGAGAGTCTAGTGCTGATCCAAGAGGAATGTGTGTCAGAGATTGCAGATCACTCTACAGAGGAGCCTGCTGAAGGAGGGCCAGATGCCGATGGAGAAGAGATGACAGATGGGATAGAGGAGGACTTCGATGAAGATGGGGGTCATGAGC
TGTTTCTACAGATAAAGTGATCTGAAATAACGCATGATGCCACAAAGCAGAAAAGAGAAACTGTGACAACCCCCAGAAATGTGAAAGGAGGTTTCTTACTGGACAGCAGCATCTTTGGTTCAATTTATATAAAAACCCAAATAAATAAAA
TGGACAGTATTGCTCAGTTTTAGAAATTCCATTTCTTCTATGTTTTAAGCTGTACAATTGTCAGGTTTTTATGGTTTAAATTGTAAATGTGTTTTCCCCTTTGCTAATTATGTTTTTTTTTTCAGTCTTAAAATGTGAAAGGCATTTATG
AATGGTAAGGGAAACACTATATACAAATGTATATTTGTAAAAGCTATTTTTATGATTAGCATGTTTCACTGTTGATCATATATAAAGTCAGGTGATATTGCAATTCTGTATTTAAAGCTTATTTCCAACAATGTCATGTAAGAAAAGATG
CATCTTATGCTAGTTTTTATAATTTATTTATAATTTATAGTTTAAAGTACTTCAGATCATAATGATAAAATACTTGAAAAAGTTATATTTCTGCCCTGTATAAGCACCCTTTTTATTAATAAAGAATGCAGATATTTCAGATGTGATATA
ATAGTTAAAGAACTGTTGGTTTGATCTGTGATTAAGTTGAGCATGCTCCGCTCTACTGAACTAAATGATCCAATTATTACTTCAGTCTGGGTATGAGATTCCATGGACAAGTAAGGACTAGATTGCCAAGGAAAAGACTGTCTTGCCCTT
GGATCCAAAAGTTTAAATTAGTGCATACATCATGTCATTTCACCTCCTGTTCCTAGGAACTCTCCATTCCCAAGCATTGCCAGTGTTTTCCAGATAATCTTAGCTGTTGTCTTGTGCTGTGGAAATGGAAGAAACCATCTTCACAGACCG
TAGGAGAATTCAACATATAATTTCTTAATAAATACTGTTTCTTTTAAAAC

C-Truncated Transcript (5CDS-3UTR) Sequences

Top

Fusion Protein Sequence for FBXO34_RALYL

In-frame Fusion Protein Sequences.

N-Truncated Protein (5UTR-3CDS) Sequences

>FBXO34_RALYL_ENST00000313833_ENST00000517638_55738255_85686813 length=178nt
MSRVNCSQFLGLCALPGCKFKDVRRNVQKDTEELKSCGIQDIFVFCTRGELSKYRVPNLLDLYQQCGIITHHHPIADGGTPDIASCCEIMEELTTCLKNYRKTLIHCYGGLGRSCLAACLLLYLSDTISPEQAIDSLRDLRGSGAIQTIK
QYNYLHEFRDKLAAHLSSRDSQSRSVSR

>FBXO34_RALYL_ENST00000313833_ENST00000518566_55738255_85686813 length=203nt
MAGEPKPYRPKPGNKRPLSALYRLESKEPFLSVGGYVFDYDYYRDDFYNRLFDYHGRVPPPPRAVIPLKRPRVAVTTTRRGKGVFSMKGGSRSTASGSTGSKLKSDELQTIKKELTQIKTKIDSLLGRLEKIEKQQKAEAEAQKKQLEES
LVLIQEECVSEIADHSTEEPAEGGPDADGEEMTDGIEEDFDEDGGHELFLQIK

>FBXO34_RALYL_ENST00000313833_ENST00000521268_55738255_85686813 length=192nt
MAGEPKPYRPKPGNKRPLSALYSGYVFDYDYYRDDFYNRLFDYHGRVPPPPRAVIPLKRPRVAVTTTRRGKGVFSMKGGSRSTASGSTGSKLKSDELQTIKKELTQIKTKIDSLLGRLEKIEKQQKAEAEAQKKQLEESLVLIQEECVSE
IADHSTEEPAEGGPDADGEEMTDGIEEDFDEDGGHELFLQIK

>FBXO34_RALYL_ENST00000313833_ENST00000521376_55738255_85686813 length=203nt
MAGEPKPYRPKPGNKRPLSALYRLESKEPFLSVGGYVFDYDYYRDDFYNRLFDYHGRVPPPPRAVIPLKRPRVAVTTTRRGKGVFSMKGGSRSTASGSTGSKLKSDELQTIKKELTQIKTKIDSLLGRLEKIEKQQKAEAEAQKKQLEES
LVLIQEECVSEIADHSTEEPAEGGPDADGEEMTDGIEEDFDEDGGHELFLQIK

>FBXO34_RALYL_ENST00000313833_ENST00000521695_55738255_85686813 length=131nt
MAGEPKPYRPKPGNKRPLSALYRLESKEPFLSVGLFDYHGRVPPPPRAVIPLKRPRVAVTTTRRGKGVFSMKGGSRSTASGSTGSKLKSDELQTIKKELTQIKTKIDSLLGRLEKIEKQQKAEAVSTDKVI

>FBXO34_RALYL_ENST00000313833_ENST00000522455_55738255_85686813 length=203nt
MAGEPKPYRPKPGNKRPLSALYRLESKEPFLSVGGYVFDYDYYRDDFYNRLFDYHGRVPPPPRAVIPLKRPRVAVTTTRRGKGVFSMKGGSRSTASGSTGSKLKSDELQTIKKELTQIKTKIDSLLGRLEKIEKQQKAEAEAQKKQLEES
LVLIQEECVSEIADHSTEEPAEGGPDADGEEMTDGIEEDFDEDGGHELFLQIK

>FBXO34_RALYL_ENST00000313833_ENST00000523850_55738255_85686813 length=203nt
MAGEPKPYRPKPGNKRPLSALYRLESKEPFLSVGGYVFDYDYYRDDFYNRLFDYHGRVPPPPRAVIPLKRPRVAVTTTRRGKGVFSMKGGSRSTASGSTGSKLKSDELQTIKKELTQIKTKIDSLLGRLEKIEKQQKAEAEAQKKQLEES
LVLIQEECVSEIADHSTEEPAEGGPDADGEEMTDGIEEDFDEDGGHELFLQIK

C-Truncated Protein (5CDS-3UTR) Sequences

Top

Personalized Fusion Protein Sequence for FBXO34_RALYL

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

Top

Fusion Gene Exprssed Samples for FBXO34_RALYL

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		KIRC	TCGA-CZ-4865-01A	FBXO34	chr14	55738255	-	RALYL	chr8	0	+
ChimerDB		KIRC	TCGA-CZ-4865-01A	FBXO34	chr14	55738255	+	RALYL	chr8	55738255	+
WashU		KIRC	TCGA-CZ-4865-01A	FBXO34	chr14	55738255	+	RALYL	chr8	85686814	+

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

Top

Related Drugs for FBXO34_RALYL

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status