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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:RMDN3_SKA2 (FusionGDB2 ID:HG55177TG348235)

Fusion Gene Summary for RMDN3_SKA2

Fusion gene summary

Fusion gene information	Fusion gene name: RMDN3_SKA2
	Fusion gene ID: hg55177tg348235
		Hgene	Tgene
	Gene symbol	RMDN3	SKA2
	Gene ID	55177	348235
	Gene name	regulator of microtubule dynamics 3	spindle and kinetochore associated complex subunit 2
	Synonyms	FAM82A2\|FAM82C\|RMD-3\|RMD3\|ptpip51	FAM33A
	Cytomap	15q15.1	17q22
	Type of gene	protein-coding	protein-coding
	Description	regulator of microtubule dynamics protein 3TCPTP-interacting protein 51cerebral protein 10family with sequence similarity 82, member A2family with sequence similarity 82, member Cmicrotubule-associated proteinprotein tyrosine phosphatase-interacting	spindle and kinetochore-associated protein 2family with sequence similarity 33, member Aspindle and KT (kinetochore) associated 2
	Modification date	20240403	20240407
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000260385, ENST00000338376, ENST00000558560,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 5 X 5 X 5=125	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 5 X 7 X 4=140
	# samples	9	16
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(9/12510)=-0.473931188332412 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(16/14010)=0.192645077942396 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: RMDN3 [Title/Abstract] AND SKA2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RMDN3(41043623)-SKA2(57189706), # samples:1

Fusion gene breakpoints across RMDN3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SKA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for RMDN3_SKA2

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
FAM82A2	chr15	41043623	SKA2	chr17	57189706
RMDN3	chr15	41037174	SKA2	chr17	57196856
RMDN3	chr15	41043623	SKA2	chr17	57189706
RMDN3	chr15	41043624	SKA2	chr17	57189706
RMDN3	chr15	40751426	SKA2	chr17	59112345

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for RMDN3_SKA2

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SKA2	GO:0031110	regulation of microtubule polymerization or depolymerization	19289083
Tgene	SKA2	GO:0051315	attachment of mitotic spindle microtubules to kinetochore	29487209

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Fusion Genomic Features for RMDN3_SKA2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
RMDN3	chr15	41037174	-	SKA2	chr17	57196856	-	5.51e-11	1.00e+00
RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-	6.25e-09	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-	6.25e-09	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for RMDN3_SKA2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000260385	ENST00000437036	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-
5CDS-5UTR	ENST00000260385	ENST00000581068	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-
5CDS-5UTR	ENST00000260385	ENST00000583380	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-
5CDS-5UTR	ENST00000260385	ENST00000583927	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-
5CDS-5UTR	ENST00000338376	ENST00000437036	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-
5CDS-5UTR	ENST00000338376	ENST00000581068	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-
5CDS-5UTR	ENST00000338376	ENST00000583380	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-
5CDS-5UTR	ENST00000338376	ENST00000583927	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-
5UTR-3CDS	ENST00000558560	ENST00000330137	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-
5UTR-3CDS	ENST00000558560	ENST00000578105	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-
5UTR-3CDS	ENST00000558560	ENST00000580541	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-
5UTR-5UTR	ENST00000558560	ENST00000437036	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-
5UTR-5UTR	ENST00000558560	ENST00000581068	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-
5UTR-5UTR	ENST00000558560	ENST00000583380	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-
5UTR-5UTR	ENST00000558560	ENST00000583927	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-
Frame-shift	ENST00000260385	ENST00000330137	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-
Frame-shift	ENST00000260385	ENST00000578105	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-
Frame-shift	ENST00000260385	ENST00000580541	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-
Frame-shift	ENST00000338376	ENST00000330137	RMDN3	chr15	41037174	-	SKA2	chr17	57196856	-
Frame-shift	ENST00000338376	ENST00000330137	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-
Frame-shift	ENST00000338376	ENST00000580541	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-
In-frame	ENST00000260385	ENST00000330137	RMDN3	chr15	41037174	-	SKA2	chr17	57196856	-
In-frame	ENST00000338376	ENST00000578105	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000260385	ENST00000330137	RMDN3	chr15	41037174	SKA2	chr17	57196856	1875	497
ENST00000338376	ENST00000578105	RMDN3	chr15	41043623	SKA2	chr17	57189706	709	362

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000558560	ENST00000330137	RMDN3	chr15	41043623	SKA2	chr17	57189706	0	101
ENST00000558560	ENST00000578105	RMDN3	chr15	41043623	SKA2	chr17	57189706	0	71
ENST00000558560	ENST00000580541	RMDN3	chr15	41043623	SKA2	chr17	57189706	0	72

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000260385	ENST00000330137	RMDN3	chr15	41037174	SKA2	chr17	57196856	5.13e-03	9.95e-01
ENST00000338376	ENST00000578105	RMDN3	chr15	41043623	SKA2	chr17	57189706	7.53e-02	9.25e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000558560	ENST00000330137	RMDN3	chr15	41043623	SKA2	chr17	57189706	0.00e+00	9.74e-01
ENST00000558560	ENST00000578105	RMDN3	chr15	41043623	SKA2	chr17	57189706	0.00e+00	9.53e-01
ENST00000558560	ENST00000580541	RMDN3	chr15	41043623	SKA2	chr17	57189706	0.00e+00	9.48e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for RMDN3_SKA2

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

RMDN3_SKA2_chr15-41037174_chr17-57196856.png

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RMDN3

chr15:41037174

chr17:57196856

ENST00000260385

Q96TC7

92_124

269.0

471.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RMDN3

chr15:41043623

chr17:57189706

ENST00000338376

Q96TC7

92_124

174.66666666666666

471.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RMDN3

chr15:41037174

chr17:57196856

ENST00000260385

Q96TC7

191_201

269.0

471.0

Compositional bias

Acidic residues

Hgene

RMDN3

chr15:41037174

chr17:57196856

ENST00000260385

Q96TC7

220_231

269.0

471.0

Compositional bias

Low complexity

Hgene

RMDN3

chr15:41037174

chr17:57196856

ENST00000260385

Q96TC7

157_163

269.0

471.0

Motif

FFAT

Hgene

RMDN3

chr15:41043623

chr17:57189706

ENST00000338376

Q96TC7

157_163

174.66666666666666

471.0

Motif

FFAT

Hgene

RMDN3

chr15:41037174

chr17:57196856

ENST00000260385

Q96TC7

168_231

269.0

471.0

Region

Disordered

Hgene

RMDN3

chr15:41037174

chr17:57196856

ENST00000260385

Q96TC7

1_12

269.0

471.0

Topological domain

Mitochondrial intermembrane

Hgene

RMDN3

chr15:41043623

chr17:57189706

ENST00000338376

Q96TC7

1_12

174.66666666666666

471.0

Topological domain

Mitochondrial intermembrane

Hgene

RMDN3

chr15:41037174

chr17:57196856

ENST00000260385

Q96TC7

13_35

269.0

471.0

Transmembrane

Helical

Hgene

RMDN3

chr15:41043623

chr17:57189706

ENST00000338376

Q96TC7

13_35

174.66666666666666

471.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RMDN3

chr15:41043623

chr17:57189706

ENST00000338376

Q96TC7

191_201

174.66666666666666

471.0

Compositional bias

Acidic residues

Hgene

RMDN3

chr15:41043623

chr17:57189706

ENST00000338376

Q96TC7

220_231

174.66666666666666

471.0

Compositional bias

Low complexity

Hgene

RMDN3

chr15:41043623

chr17:57189706

ENST00000338376

Q96TC7

168_231

174.66666666666666

471.0

Region

Disordered

Hgene

RMDN3

chr15:41037174

chr17:57196856

ENST00000260385

Q96TC7

36_470

269.0

471.0

Topological domain

Cytoplasmic

Hgene

RMDN3

chr15:41043623

chr17:57189706

ENST00000338376

Q96TC7

36_470

174.66666666666666

471.0

Topological domain

Cytoplasmic

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for RMDN3_SKA2

In-frame Fusion Transcript Sequences.

>RMDN3_SKA2_ENST00000260385_ENST00000330137_41037174_57196856 length=4447nt 
 Breakpoint=1875nt
TGTTATCATAGTCCATAAAATCGGTCTTTTTAGTTGCCACAATTATAAGAAGTTGCATACAATTACAAGAGTAAAACAGAATTATAAGACAGCACGTTAGGTTTAAGATTTATGGCCGGGTGCGGCGGCTCACGCACTTTGGGAGCCCGA
GGCGGGCGGATCGCACTTTGAGAGACCAGGAGAGCGGGACCCAGTCTCTACAAAATAAAAATAAAAATAAAATGTGGGGAGAGCGTGACGTTTTCCAGGTACAGAGGGGAGGTCCAGGCAGAAGCGCAGGTAGAAAGTGTGAATATGCTG
AGCGTATTCCGGGAGCAGCAAGTTAAGCCGGTGTGACCGGAGGGAAATGGAGGCCTGGCTGCCGGACGGTGAGGGTGACTGCGCGAGCGTCCGCCCAAGAAGTCTCCCTGCCTTCCCGCCTTTCCCCTGTCTTGGGCCCCTTCTTGCTTT
CCTTTCGCGCTCTGTGCTGACTCCGCCCCTCCGGCGGCGCCCGTGGCCCCGCCCCTGAGGGAAACAGACAAGGGGCGGGGCCGGCGCGGTCATCTCTCTGCGCCTTCCCGCAGGGCGCCGAGCACCTGGCGCCGCCTGCCTGACGTCACG
GTCACTGACAGCGTGAGCCCGCGGCGGCTGCTGCCATGGTGGCTGGCGGCCGGGTAAGGGTCTGAGTGGATCTCCTGCCAGGCCAGAGCGCCTTCGGGGGCCGCGGCGGAAGGCCAGGAGTTTGCAGCCAGGGCGCCGGGTTTGTGGTCT
GCAGTGTCGTGAGGCTGAGGTGGGGGTTGAAGGCCCAGAAGCCGGACTCTGTGACCCGGGTCGGGGGGTGTACTGGAGGGGCGGCTACGTCCAGGCTGGGTGAGAAGAGAGGCAGTGGGGCCCAGGAGGCTGGAGGAAGCCTTAGGGTTC
AGACTGGGGTGCACGTAGTCGAGAGCTCAGGGTTTGGGCAAGGGGATACCTGCCGGGGTTCAGCCTTGAGGGTGGGTTTACCGGGTTCACGAATCTCTCTCTCTCCTTACCCCCGCCCGCCCGCCCGCCTGCCTGCTCCCGGTGACTTCT
GCTGGCCGCAGGTGCAGCATGTCTAGACTGGGAGCCCTGGGTGGTGCCCGTGCCGGGCTGGGACTGTTGCTGGGTACCGCCGCCGGCCTTGGATTCCTGTGCCTCCTTTACAGCCAGCGATGGAAACGGACCCAGCGTCATGGCCGCAGC
CAGAGCCTGCCCAACTCCCTGGACTATACGCAGACTTCAGATCCCGGACGCCACGTGATGCTCCTGCGGGCTGTCCCAGGTGGGGCTGGAGATGCCTCAGTGCTGCCCAGCCTTCCACGGGAAGGACAGGAGAAGGTGCTGGACCGCCTG
GACTTTGTGCTGACCAGCCTTGTGGCGCTGCGGCGGGAGGTGGAGGAGCTGAGAAGCAGCCTGCGAGGGCTTGCGGGGGAGATTGTTGGGGAGGTCCGATGCCACATGGAAGAGAACCAGAGAGTGGCTCGGCGGCGAAGGTTTCCGTTT
GTCCGGGAGAGGAGTGACTCCACTGGCTCCAGCTCTGTCTACTTCACGGCCTCCTCGGGAGCCACGTTCACAGATGCTGAGAGTGAAGGGGGTTACACAACAGCCAATGCGGAGTCTGACAATGAGCGGGACTCTGACAAAGAAAGTGAG
GACGGGGAAGATGAAGTGAGCTGTGAGACTGTGAAGATGGGGAGAAAGGATTCTCTTGACTTGGAGGAAGAGGCAGCTTCAGGTGCCTCCAGTGCCCTGGAGGCTGGAGGTTCCTCAGGCTTGGAGGATGTGCTGCCCCTCCTGCAGCAG
GCCGACGAGCTGCACAGGGGTGATGAGCAAGGCAAGCGGGAGGGCTTCCAGCTGCTGCTCAACAACAAGCTGGTGAAAAATCCAGTTACACTCTTAAAGGAATTGTCAGTGATAAAGTCTCGATATCAAACTTTGTATGCCCGCTTTAAA
CCAGTTGCTGTTGAGCAGAAAGAGAGTAAGAGCCGCATTTGTGCTACTGTGAAAAAGACTATGAATATGATACAAAAACTACAGAAGCAAACAGACCTGGAGCTGTCACCACTGACTAAAGAAGAGAAAACTGCGGCAGAGCAATTCAAA
TTTCACATGCCAGATTTATGAAGAAATGGACTTGGAAAGGAAATTCTAACAGAGAAGAGCTTAATTCCGGAGAAATTTAGGAAGATGTCTTGTTAACCCTTGATGTCTAGAGATTGGGGGCTGGTGAAGGGGGTTTGGCTTCAATGACTG
GATAATGATATCTTTCATGAGAGAGATTATAAGAAGAAGGGCAGATAATATATGAATAAAGTTCAGCCAAAAGGATCAAATGAGAATAAAACGATTTAAATATATGTACACACGCATGCACACACACACTTAGTCTTGTAATTTCAGGCC
AGAAATTCTCAACACTATTTTGCATCTGTTTTCTTTTTCTAAGTCATGATAATATAGATGTTCTGGTCTATCATAAAAGAATGTTTATGTACATTTCAGTCATTCGGTATGTGGCTTTGTAAATTAAAGTATAGGCAAAACATTTGTGTT
ATACATGATATATAATTTCATTTTGTAAATGTTGATTGCACATGTGGTCACATTATTGTTGAGACTGCTTTTATGTGACCTGTAGTCTCCCACAGAACCTAAAGTAATAAGCTGGCTTTTCTGTGATAGCCACGTTTGCGTATTTCTTTC
CCTATTTCCCTTGCCTGCTAATGTTGAACAGCATGAACTTGCTTTCTGATGCTGTTTTAGACTGTCCCTGTTGTATCTCAATAATATCTTTGTTTTCCTTCAGCCTTTATTACTATAATTGTTCATTCTACATGAAAGCTAGGAAACTGA
AATTAGAAGAGCACTTATCTGCTACTTGCCAGTTTTGCGTGAGTGTGTTATATGTATGTGTCAATTTCCCTTTAAAATAACTATTTATTTTAAAATAACTATTGGCAATAAGGAAACTGTTCAAAGTAGAGGCAGATCTTGATAGAAAGA
TGTTAATCACAGGGTTGTTTATAATAGCAATATACATACACATTTGGCTAGTACTAGGTGAATAGGAAAATAAATCATGCTGTATGTATACAATAAGAGGTCAAGTTGCCAATAAATTATTACTGTTAATGTTCTGGGAAATGCTGAAAC
TATGCTAAGTGGGGGAGAGGGAAAGCAGGTATTGCAGTTTTGTAGTGAAGATTGGGCTTTGGAGTCATATCTGAGATGTAAGTAGCAGCTTTTAAATTCTAGCTATGACCCTGTGCAGATCACTTAACTTTTGAGTGTCAGGATGTTTGG
AAGGACAAGACAGGAAAGTGTTTTAATACAGGGTTCAGTATTTAGTAAGCCTTCAATAAGTGATATTACATACATGTAATAAAAACTAAGCATTGAAAGGACTAGGAAAAATGCATCAAATGTTAGTTCTGCAGGTTATAGAATTATACT
TTTATGTAATTTTAAAATTTCAGTTATGAACATGTTTGTCCATTAACAAACTTATAATAGCTGAAAAACAGGGTTGTGAGAACAGCTTCAGTTAAAATTGTCCTGTCTAGTTTGAATATTTCAAGAACAGAAAGCCTTTTTTTTTTTTTT
TTTTTTTTTGAGACGGAGTCTCACTCTGTTGCCCAGGCTGGAATGCAGTGGTACGCTCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCAGTTCTCTGCCCCACCCTCCCGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCC
CGGCTATTTTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATCTTGACCAGGCTGGTCTTTAACTCCTGATGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCTACCGTGCCTGGCCCCCTTTTTTTTAA
TTACAGAGAAATAAGTTACACCTTAGTATCAGATATTAATTTTCTTCAGTGTTCAGGCAATTAGTATTTAGAAAGCTCTTGTCATGAGATGGCTCTGGGATGTGATGATGATTGTTGGGATTGAAAAAACGGTAGTATCATGGAGAGATC
ATAATAAATTCTTAGTATTAAAAGTGGTTTTGCTTTCAGTTAGGGAGAAAAATTAGATTGTACTATTTTTCCTCTATGATTTCCTTCAGTTATCTTCCAAATGTTGTTTTTTCCCCACAGCCCCCTTAACATTGTTCTCTATGCACTTCT
CAATACATTTTCATTTGTTTCTCAAGCCTCTTTGTGGATGACTCCTAAATATAACTTCTTCCACTAGCTCTAGATCCGTATTTCCAATAAAATCCCCTACCTGAATATTCAAGTTAAACATGTCCAGAATACTTACTGATTTTATTGTTA
ATAGCCACTATTCTGTTGTCTGGAATTAAAACCTGTATAACTAATTTGCATCCCTTTATCTTCTTAGTCAATAAAACCTACAATCCTCTTTCTAAAA

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706 length=1167nt 
 Breakpoint=709nt
GACGTCACGGTCACTGACAGCGTGAGCCCGCGGCGGCTGCTGCCATGGTGGCTGGCGGCCGGGTAAGGGTCTGAGTGGATCTCCTGCCAGGCCAGAGCGCCTTCGGGGGCCGCGGCGGAAGGCCAGGAGTTTGCAGCCAGGGCGCCGGGT
TTGTGGTCTGCAGTGTCGTGAGGCTGAGGTGCAGCATGTCTAGACTGGGAGCCCTGGGTGGTGCCCGTGCCGGGCTGGGACTGTTGCTGGGTACCGCCGCCGGCCTTGGATTCCTGTGCCTCCTTTACAGCCAGCGATGGAAACGGACCC
AGCGTCATGGCCGCAGCCAGAGCCTGCCCAACTCCCTGGACTATACGCAGACTTCAGATCCCGGACGCCACGTGATGCTCCTGCGGGCTGTCCCAGGTGGGGCTGGAGATGCCTCAGTGCTGCCCAGCCTTCCACGGGAAGGACAGGAGA
AGGTGCTGGACCGCCTGGACTTTGTGCTGACCAGCCTTGTGGCGCTGCGGCGGGAGGTGGAGGAGCTGAGAAGCAGCCTGCGAGGGCTTGCGGGGGAGATTGTTGGGGAGGTCCGATGCCACATGGAAGAGAACCAGAGAGTGGCTCGGC
GGCGAAGGTTTCCGTTTGTCCGGGAGAGGAGTGACTCCACTGGCTCCAGCTCTGTCTACTTCACGGCCTCCTCGGGAGCCACGTTCACAGATGCTGAGAGTGAAGGGGGCTGTCACCACTGACTAAAGAAGAGAAAACTGCGGCAGAGCA
ATTCAAATTTCACATGCCAGATTTATGAAGAAATGGACTTGGAAAGGAAATTCTAACAGAGAAGAGCTTAATTCCGGAGAAATTTAGGAAGATGTCTTGTTAACCCTTGATGTCTAGAGATTGGGGGCTGGTGAAGGGGGTTTGGCTTCA
ATGACTGGATAATGATATCTTTCATGAGAGAGATTATAAGAAGAAGGGCAGATAATATATGAATAAAGTTCAGCCAAAAGGATCAAATGAGAATAAAACGATTTAAATATATGTACACACGCATGCACACACACACTTAGTCTTGTAATT
TCAGGCCAGAAATTCTCAACACTATTTTGCATCTGTTTTCTTTTTCTAAGTCATGATAATATAGATGTTCTGGTCTATCATAAAAGAATGTTTATGTACATTTCAGTCATTCGGTAT

N-Truncated Transcript (5UTR-3CDS) Sequences

>RMDN3_SKA2_ENST00000558560_ENST00000330137_41043623_57189706 length=2395nt 
 Breakpoint=0nt
CTGTCACCACTGACTAAAGAAGAGAAAACTGCGGCAGAGCAATTCAAATTTCACATGCCAGATTTATGAAGAAATGGACTTGGAAAGGAAATTCTAACAGAGAAGAGCTTAATTCCGGAGAAATTTAGGAAGATGTCTTGTTAACCCTTG
ATGTCTAGAGATTGGGGGCTGGTGAAGGGGGTTTGGCTTCAATGACTGGATAATGATATCTTTCATGAGAGAGATTATAAGAAGAAGGGCAGATAATATATGAATAAAGTTCAGCCAAAAGGATCAAATGAGAATAAAACGATTTAAATA
TATGTACACACGCATGCACACACACACTTAGTCTTGTAATTTCAGGCCAGAAATTCTCAACACTATTTTGCATCTGTTTTCTTTTTCTAAGTCATGATAATATAGATGTTCTGGTCTATCATAAAAGAATGTTTATGTACATTTCAGTCA
TTCGGTATGTGGCTTTGTAAATTAAAGTATAGGCAAAACATTTGTGTTATACATGATATATAATTTCATTTTGTAAATGTTGATTGCACATGTGGTCACATTATTGTTGAGACTGCTTTTATGTGACCTGTAGTCTCCCACAGAACCTAA
AGTAATAAGCTGGCTTTTCTGTGATAGCCACGTTTGCGTATTTCTTTCCCTATTTCCCTTGCCTGCTAATGTTGAACAGCATGAACTTGCTTTCTGATGCTGTTTTAGACTGTCCCTGTTGTATCTCAATAATATCTTTGTTTTCCTTCA
GCCTTTATTACTATAATTGTTCATTCTACATGAAAGCTAGGAAACTGAAATTAGAAGAGCACTTATCTGCTACTTGCCAGTTTTGCGTGAGTGTGTTATATGTATGTGTCAATTTCCCTTTAAAATAACTATTTATTTTAAAATAACTAT
TGGCAATAAGGAAACTGTTCAAAGTAGAGGCAGATCTTGATAGAAAGATGTTAATCACAGGGTTGTTTATAATAGCAATATACATACACATTTGGCTAGTACTAGGTGAATAGGAAAATAAATCATGCTGTATGTATACAATAAGAGGTC
AAGTTGCCAATAAATTATTACTGTTAATGTTCTGGGAAATGCTGAAACTATGCTAAGTGGGGGAGAGGGAAAGCAGGTATTGCAGTTTTGTAGTGAAGATTGGGCTTTGGAGTCATATCTGAGATGTAAGTAGCAGCTTTTAAATTCTAG
CTATGACCCTGTGCAGATCACTTAACTTTTGAGTGTCAGGATGTTTGGAAGGACAAGACAGGAAAGTGTTTTAATACAGGGTTCAGTATTTAGTAAGCCTTCAATAAGTGATATTACATACATGTAATAAAAACTAAGCATTGAAAGGAC
TAGGAAAAATGCATCAAATGTTAGTTCTGCAGGTTATAGAATTATACTTTTATGTAATTTTAAAATTTCAGTTATGAACATGTTTGTCCATTAACAAACTTATAATAGCTGAAAAACAGGGTTGTGAGAACAGCTTCAGTTAAAATTGTC
CTGTCTAGTTTGAATATTTCAAGAACAGAAAGCCTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTTGCCCAGGCTGGAATGCAGTGGTACGCTCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCAGTTCTCT
GCCCCACCCTCCCGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCCCGGCTATTTTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATCTTGACCAGGCTGGTCTTTAACTCCTGATGGTGATCCACCCACCTCGGCCTCCCAAAGT
GCTGGGATTACAGGCATGAGCTACCGTGCCTGGCCCCCTTTTTTTTAATTACAGAGAAATAAGTTACACCTTAGTATCAGATATTAATTTTCTTCAGTGTTCAGGCAATTAGTATTTAGAAAGCTCTTGTCATGAGATGGCTCTGGGATG
TGATGATGATTGTTGGGATTGAAAAAACGGTAGTATCATGGAGAGATCATAATAAATTCTTAGTATTAAAAGTGGTTTTGCTTTCAGTTAGGGAGAAAAATTAGATTGTACTATTTTTCCTCTATGATTTCCTTCAGTTATCTTCCAAAT
GTTGTTTTTTCCCCACAGCCCCCTTAACATTGTTCTCTATGCACTTCTCAATACATTTTCATTTGTTTCTCAAGCCTCTTTGTGGATGACTCCTAAATATAACTTCTTCCACTAGCTCTAGATCCGTATTTCCAATAAAATCCCCTACCT
GAATATTCAAGTTAAACATGTCCAGAATACTTACTGATTTTATTGTTAATAGCCACTATTCTGTTGTCTGGAATTAAAACCTGTATAACTAATTTGCATCCCTTTATCTTCTTAGTCAATAAAACCTACAATCCTCTTTCTAAAA

>RMDN3_SKA2_ENST00000558560_ENST00000578105_41043623_57189706 length=458nt 
 Breakpoint=0nt
CTGTCACCACTGACTAAAGAAGAGAAAACTGCGGCAGAGCAATTCAAATTTCACATGCCAGATTTATGAAGAAATGGACTTGGAAAGGAAATTCTAACAGAGAAGAGCTTAATTCCGGAGAAATTTAGGAAGATGTCTTGTTAACCCTTG
ATGTCTAGAGATTGGGGGCTGGTGAAGGGGGTTTGGCTTCAATGACTGGATAATGATATCTTTCATGAGAGAGATTATAAGAAGAAGGGCAGATAATATATGAATAAAGTTCAGCCAAAAGGATCAAATGAGAATAAAACGATTTAAATA
TATGTACACACGCATGCACACACACACTTAGTCTTGTAATTTCAGGCCAGAAATTCTCAACACTATTTTGCATCTGTTTTCTTTTTCTAAGTCATGATAATATAGATGTTCTGGTCTATCATAAAAGAATGTTTATGTACATTTCAGTCA
TTCGGTAT

>RMDN3_SKA2_ENST00000558560_ENST00000580541_41043623_57189706 length=460nt 
 Breakpoint=0nt
CTGTCACCACTGACTAAAGAAGAGAAAACTGCGGCAGAGCAATTCAAATTTCACATGCCAGATTTATGAAGAAATGGACTTGGAAAGGAAATTCTAACAGAGAAGAGCTTAATTCCGGAGAAATTTAGGAAGATGTCTTGTTAACCCTTG
ATGTCTAGAGATTGGGGGCTGGTGAAGGGGGTTTGGCTTCAATGACTGGATAATGATATCTTTCATGAGAGAGATTATAAGAAGAAGGGCAGATAATATATGAATAAAGTTCAGCCAAAAGGATCAAATGAGAATAAAACGATTTAAATA
TATGTACACACGCATGCACACACACACTTAGTCTTGTAATTTCAGGCCAGAAATTCTCAACACTATTTTGCATCTGTTTTCTTTTTCTAAGTCATGATAATATAGATGTTCTGGTCTATCATAAAAGAATGTTTATGTACATTTCAGTCA
TTCGGTATGT

C-Truncated Transcript (5CDS-3UTR) Sequences

Top

Fusion Protein Sequence for RMDN3_SKA2

In-frame Fusion Protein Sequences.

>RMDN3_SKA2_ENST00000260385_ENST00000330137_41037174_57196856 length=497nt
MQVMALAARLWRLLPFRRGAAPGSRLPAGTSGSRGHCGPCRFRGFEVMGNPGTFKRGLLLSALSYLGFETYQVISQAAVVHATAKDHRFSDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNA
QGRRNGEALVRFVSEEHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRYIELFRSTAAEVQQ
VLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADRAFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCKLPCLSPPSYTFPA
PAAVIPTEAAIYQPSVILNPRALQPSTAYYPAGTQLFMNYTAYYPSV

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706 length=362nt
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

N-Truncated Protein (5UTR-3CDS) Sequences

>RMDN3_SKA2_ENST00000558560_ENST00000330137_41043623_57189706 length=101nt
MIGVQWHDLSLLQPPSPRFKQFPASASPVAGIIGTHHHAWLIFAFLVEIRFHHVGQAGLELLTSGDSPASASQSAGITGVSHRAQPMQTFLSAIGIHFISN

>RMDN3_SKA2_ENST00000558560_ENST00000578105_41043623_57189706 length=71nt
MKTIPSHIADTKGKTVLMGLRVLWSSSFVWSCKVLTIFTSHITKLVHRRSWWILSIPEDTLCLCSRTGTAV

>RMDN3_SKA2_ENST00000558560_ENST00000580541_41043623_57189706 length=72nt
MQNSVENFWPEITRLSVCVHACVHIFKSFYSHLILLAELYSYIICPSSYNLSHERYHYPVIEAKPPSPAPNL

C-Truncated Protein (5CDS-3UTR) Sequences

Top

Personalized Fusion Protein Sequence for RMDN3_SKA2

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.A12T_362_A24T length=362AA
MLPVTSAGRRCSMSRLGALGGARTGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.E247K_362_E259K length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADKLHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_3-gene_p.F64V_362_F305V length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARVKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.G23R_362_G35R length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAARLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.E186V_362_E198V length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNVRDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.S224C_362_S236C length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGACSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.H41Y_362_H53Y length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRYGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_3-gene_p.E49Q_362_E290Q length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKQLSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.Q87H;p.A179S_362_Q99H;A191S length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGHEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTSNAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.S172G_362_S184G length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAEGEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_3-gene_p.K48N_362_K289N length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLNELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.S163A_362_S175A length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASAGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_3-gene_p.K115R_362_K356R length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFRFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.R93H_362_R105H length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDHLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.L30I_362_L42I length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLIYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.M130T;p.A229T_362_M142T;A241T length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHTEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALETGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.E247K_362_E259K length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADKLHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_3-gene_p.S76T_362_S317T length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKTRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.A161T_362_A173T length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTTSSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.R146Q_362_R158Q length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVQERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_3-gene_p.P119S_362_P360S length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMSDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_3-gene_p.R77H_362_R318H length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSHICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_3-gene_p.S55P_362_S296P length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKPRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.L241I_362_L253I length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPILQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.E186K_362_E198K length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNKRDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_3-gene_p.D120N_362_D361N length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPNL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_both_p.V108L-p.L103M_362_V120L;L344M length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRRELEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPMTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.A73D_362_A85D length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGDGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.D190N_362_D202N length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSNKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.V63L_362_V75L length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHLMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.P143Q_362_P155Q length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFQFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.R106L_362_R118L length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRLEVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.L213V_362_L225V length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSVDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.H249Y_362_H261Y length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELYRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.R93H;p.I122V_362_R105H;I134V length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDHLDFVLTSLVALRREVEELRSSLRGLAGEVVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.D188N_362_D200N length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERNSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.A73T_362_A85T length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGTGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.S154Y_362_S166Y length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGYSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.S155N_362_S167N length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSNSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_3-gene_p.K94E_362_K335E length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQEQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.R34Q_362_R46Q length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQQWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.S224C_362_S236C length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGACSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

>RMDN3_SKA2_ENST00000338376_ENST00000578105_41043623_57189706_5-gene_p.R106W_362_R118W length=362AA
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRWEVEELRSSLRGLAGEIVGEVRCHMEENQRVAR
RRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVKNPVTLLKELSVIKSRYQT
LYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL

Fusion Protein ID	Sample ID	Mutated Partner	AAchange in WT	Seq. Length	AAchange in Fusion
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-06-0939-01A	5-gene	p.A12T	362	A24T
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-2W-A8YY-01A	5-gene	p.E247K	362	E259K
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-3N-A9WC-06A	3-gene	p.F64V	362	F305V
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-44-7670-01A	5-gene	p.G23R	362	G35R
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-55-8096-01A	5-gene	p.E186V	362	E198V
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-56-8503-01A	5-gene	p.S224C	362	S236C
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-63-A5MH-01A	5-gene	p.H41Y	362	H53Y
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-92-8065-01A	3-gene	p.E49Q	362	E290Q
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-A5-A0G2-01A	5-gene	p.Q87H;p.A179S	362	Q99H;A191S
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-AA-3492-01A	5-gene	p.S172G	362	S184G
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-AJ-A3EK-01A	3-gene	p.K48N	362	K289N
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-AO-A128-01A	5-gene	p.S163A	362	S175A
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-AX-A0J0-01A	3-gene	p.K115R	362	K356R
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-AX-A1C5-01A	5-gene	p.R93H	362	R105H
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-B0-5692-01A	5-gene	p.L30I	362	L42I
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-B5-A3FA-01A	5-gene	p.M130T;p.A229T	362	M142T;A241T
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-B5-A3FC-01A	5-gene	p.E247K	362	E259K
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-BR-6452-01A	3-gene	p.S76T	362	S317T
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-BR-8680-01A	5-gene	p.A161T	362	A173T
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-CD-A48A-01A	5-gene	p.R146Q	362	R158Q
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-CD-A4MJ-01A	3-gene	p.P119S	362	P360S
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-D1-A15X-01A	3-gene	p.R77H	362	R318H
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-D1-A16Y-01A	3-gene	p.S55P	362	S296P
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-D3-A2JC-06A	5-gene	p.L241I	362	L253I
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-D8-A1JA-01A	5-gene	p.E186K	362	E198K
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-DI-A0WH-01A	3-gene	p.D120N	362	D361N
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-DK-A3X1-01A	both	p.V108L-p.L103M	362	V120L;L344M
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-DX-A6YT-01A	5-gene	p.A73D	362	A85D
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-E2-A2P6-01A	5-gene	p.D190N	362	D202N
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-EE-A2M7-06A	5-gene	p.V63L	362	V75L
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-EE-A2MQ-06A	5-gene	p.P143Q	362	P155Q
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-ER-A2NF-06A	5-gene	p.R106L	362	R118L
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-EY-A1GS-01A	5-gene	p.L213V	362	L225V
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-FI-A2D0-01A	5-gene	p.H249Y	362	H261Y
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-FI-A2D5-01A	5-gene	p.R93H;p.I122V	362	R105H;I134V
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-G2-A2ES-01A	5-gene	p.D188N	362	D200N
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-GN-A263-01A	5-gene	p.A73T	362	A85T
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-HV-A7OP-01A	5-gene	p.S154Y	362	S166Y
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-IB-7651-01A	5-gene	p.S155N	362	S167N
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-ND-A4WC-01A	3-gene	p.K94E	362	K335E
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-UY-A9PF-01A	5-gene	p.R34Q	362	R46Q
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-VS-A8EL-01A	5-gene	p.S224C	362	S236C
ENST00000338376_ENST00000578105_41043623_57189706	TCGA-XF-AAN0-01A	5-gene	p.R106W	362	R118W

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for RMDN3_SKA2

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		BRCA	TCGA-C8-A1HI	FAM82A2	chr15	41043623	-	SKA2	chr17	57189706	-
ChimerDB		BRCA	TCGA-C8-A1HI-01A	RMDN3	chr15	41037174	-	SKA2	chr17	57196856	-
ChimerDB		BRCA	TCGA-C8-A1HI-01A	RMDN3	chr15	41043623	-	SKA2	chr17	57189706	-
WashU		BRCA	TCGA-C8-A1HI-01A	RMDN3	chr15	41043624	-	SKA2	chr17	57189706	-
cBioPortal	BRCA_TCGA_PAN_CAN_ATLAS_2018	BRCA	TCGA-C8-A1HI-01	RMDN3	chr15	40751426		SKA2	chr17	59112345

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for RMDN3_SKA2

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status