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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene Breakpoints

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness

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Fusion Genomic Features

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Fusion Gene ORF Annotations

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Fusion Protein Retained/Non-Retained Functional Features

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Fusion Transcript Sequences

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Fusion Protein Sequences

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Personalized Fusion Protein Sequences

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Fusion Gene Expressed Samples

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Related Drugs

Fusion gene:OTUD5_GRIPAP1 (FusionGDB2 ID:HG55593TG56850)

Fusion Gene Summary for OTUD5_GRIPAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: OTUD5_GRIPAP1
Fusion gene ID: hg55593tg56850
HgeneTgene
Gene symbol

OTUD5

GRIPAP1

Gene ID

55593

56850

Gene nameOTU deubiquitinase 5GRIP1 associated protein 1
SynonymsDUBA|MCANDGRASP-1
Cytomap

Xp11.23

Xp11.23

Type of geneprotein-codingprotein-coding
DescriptionOTU domain-containing protein 5OTU domain containing 5deubiquinating enzyme Adeubiquitinase Adeubiquitinating enzyme AGRIP1-associated protein 1
Modification date2024030520240305
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000156084, ENST00000376488, 
ENST00000396743, ENST00000428668, 
ENST00000484499, 
Fusion gene scores* DoF score* DoF score (Degree of Frequency) = # partners X # break points X # disease types
9 X 10 X 23=2070		* DoF score (Degree of Frequency) = # partners X # break points X # disease types
1 X 6 X 6=36
# samples 51116
** MAII score** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)
log2(51/2070*10)=-2.02106161552783
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)
log2(116/36*10)=5.00998408857262
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: OTUD5 [Title/Abstract] AND GRIPAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointOTUD5(48791736)-GRIPAP1(48855916), # samples:2

check buttonFusion gene breakpoints across OTUD5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across GRIPAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Fusion Gene Breakpoints for OTUD5_GRIPAP1


check button RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.
HgeneHchrHbpTgeneTchrTbp
OTUD5chrX48791737GRIPAP1chrX48855916
OTUD5chrX48814242GRIPAP1chrX48855916


check button DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.
HgeneHchrHbpTgeneTchrTbpSV type


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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for OTUD5_GRIPAP1


check button To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.
* We have 10 tumorigenic mechanism categories of fusion genes as shown below.
Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand FusionsAberrant Chimeric Transcription Factor / Fusion Transcription Factor ActivityEpigenetic Reprogramming / Histone Modifier DysregulationChromatin Remodeling DysregulationCondensate-Driven Transcriptional Rewiring / LLPPromoter / Enhancer HijackingDominant-Negative AntagonismCell Cycle / Checkpoint Bypass / RNA Processing DysregulationSubcellular Mislocalization / Spatial DysregulationNuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.
Fusion Gene NameMechanism CategoryMechanism PubMedTumorigenic ScenariosTumorigenic Scenario PubMedTargeting PointsTargeting PubMedMechanism BackgroundMechanism Background PubMed

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.
Fusion Gene NameMechanism CategoryMechanism PubMedTumorigenic ScenariosTumorigenic Scenario PubMedTargeting PointsTargeting PubMedMechanism BackgroundMechanism Background PubMed

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOTUD5

GO:0016579

protein deubiquitination

22245969

HgeneOTUD5

GO:0032496

response to lipopolysaccharide

22245969

HgeneOTUD5

GO:0070536

protein K63-linked deubiquitination

22245969|23827681

HgeneOTUD5

GO:0071108

protein K48-linked deubiquitination

22245969|23827681


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Fusion Genomic Features for OTUD5_GRIPAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
OTUD5chrX48791736-GRIPAP1chrX48855916-1.37e-091.00e+00
OTUD5chrX48814242-GRIPAP1chrX48855916-1.97e-101.00e+00


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).
genomic feature

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Fusion Gene ORF Annotations for OTUD5_GRIPAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000484499ENST00000376425OTUD5chrX

48791736

-GRIPAP1chrX

48855916

-
5UTR-3CDSENST00000484499ENST00000376425OTUD5chrX

48814242

-GRIPAP1chrX

48855916

-
5UTR-3CDSENST00000484499ENST00000376441OTUD5chrX

48791736

-GRIPAP1chrX

48855916

-
5UTR-3CDSENST00000484499ENST00000376441OTUD5chrX

48814242

-GRIPAP1chrX

48855916

-
5UTR-3CDSENST00000484499ENST00000376444OTUD5chrX

48791736

-GRIPAP1chrX

48855916

-
5UTR-3CDSENST00000484499ENST00000376444OTUD5chrX

48814242

-GRIPAP1chrX

48855916

-
Frame-shiftENST00000396743ENST00000376425OTUD5chrX

48791736

-GRIPAP1chrX

48855916

-
Frame-shiftENST00000396743ENST00000376441OTUD5chrX

48791736

-GRIPAP1chrX

48855916

-
Frame-shiftENST00000396743ENST00000376444OTUD5chrX

48791736

-GRIPAP1chrX

48855916

-
Frame-shiftENST00000428668ENST00000376425OTUD5chrX

48791736

-GRIPAP1chrX

48855916

-
Frame-shiftENST00000428668ENST00000376441OTUD5chrX

48791736

-GRIPAP1chrX

48855916

-
Frame-shiftENST00000428668ENST00000376444OTUD5chrX

48791736

-GRIPAP1chrX

48855916

-
In-frameENST00000156084ENST00000376425OTUD5chrX

48791736

-GRIPAP1chrX

48855916

-
In-frameENST00000156084ENST00000376425OTUD5chrX

48814242

-GRIPAP1chrX

48855916

-
In-frameENST00000156084ENST00000376441OTUD5chrX

48791736

-GRIPAP1chrX

48855916

-
In-frameENST00000156084ENST00000376441OTUD5chrX

48814242

-GRIPAP1chrX

48855916

-
In-frameENST00000156084ENST00000376444OTUD5chrX

48791736

-GRIPAP1chrX

48855916

-
In-frameENST00000156084ENST00000376444OTUD5chrX

48814242

-GRIPAP1chrX

48855916

-
In-frameENST00000376488ENST00000376425OTUD5chrX

48791736

-GRIPAP1chrX

48855916

-
In-frameENST00000376488ENST00000376425OTUD5chrX

48814242

-GRIPAP1chrX

48855916

-
In-frameENST00000376488ENST00000376441OTUD5chrX

48791736

-GRIPAP1chrX

48855916

-
In-frameENST00000376488ENST00000376441OTUD5chrX

48814242

-GRIPAP1chrX

48855916

-
In-frameENST00000376488ENST00000376444OTUD5chrX

48791736

-GRIPAP1chrX

48855916

-
In-frameENST00000376488ENST00000376444OTUD5chrX

48814242

-GRIPAP1chrX

48855916

-
In-frameENST00000396743ENST00000376425OTUD5chrX

48814242

-GRIPAP1chrX

48855916

-
In-frameENST00000396743ENST00000376441OTUD5chrX

48814242

-GRIPAP1chrX

48855916

-
In-frameENST00000396743ENST00000376444OTUD5chrX

48814242

-GRIPAP1chrX

48855916

-

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score

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Fusion Protein Retained/Non-Retained Functional Features for OTUD5_GRIPAP1

check buttonProtein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.
fgviewer annotation
- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).
OTUD5_GRIPAP1_chrX-48791736_chrX-48855916.png
OTUD5_GRIPAP1_chrX-48791736_chrX-48855916.png
OTUD5_GRIPAP1_chrX-48814242_chrX-48855916.png
OTUD5_GRIPAP1_chrX-48814242_chrX-48855916.png

- In-frame and retained protein feature among the 13 regional features (texts).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOTUD5chrX:48791736chrX:48855916ENST00000156084Q96G745911_30358.0572.0Compositional biasPro residues
HgeneOTUD5chrX:48791736chrX:48855916ENST00000156084Q96G745932_47358.0572.0Compositional biasGly residues
HgeneOTUD5chrX:48791736chrX:48855916ENST00000156084Q96G745963_75358.0572.0Compositional biasPro residues
HgeneOTUD5chrX:48791736chrX:48855916ENST00000156084Q96G745984_97358.0572.0Compositional biasLow complexity
HgeneOTUD5chrX:48814242chrX:48855916ENST00000156084Q96G741911_30198.0572.0Compositional biasPro residues
HgeneOTUD5chrX:48814242chrX:48855916ENST00000156084Q96G741932_47198.0572.0Compositional biasGly residues
HgeneOTUD5chrX:48814242chrX:48855916ENST00000156084Q96G741963_75198.0572.0Compositional biasPro residues
HgeneOTUD5chrX:48814242chrX:48855916ENST00000156084Q96G741984_97198.0572.0Compositional biasLow complexity
HgeneOTUD5chrX:48791736chrX:48855916ENST00000156084Q96G7459213_341358.0572.0DomainOTU
HgeneOTUD5chrX:48791736chrX:48855916ENST00000156084Q96G7459146_175358.0572.0RegionDisordered
HgeneOTUD5chrX:48791736chrX:48855916ENST00000156084Q96G74591_111358.0572.0RegionDisordered
HgeneOTUD5chrX:48791736chrX:48855916ENST00000156084Q96G7459218_224358.0572.0RegionCys-loop
HgeneOTUD5chrX:48791736chrX:48855916ENST00000156084Q96G7459273_283358.0572.0RegionVariable-loop
HgeneOTUD5chrX:48791736chrX:48855916ENST00000156084Q96G7459329_334358.0572.0RegionHis-loop
HgeneOTUD5chrX:48814242chrX:48855916ENST00000156084Q96G7419146_175198.0572.0RegionDisordered
HgeneOTUD5chrX:48814242chrX:48855916ENST00000156084Q96G74191_111198.0572.0RegionDisordered
TgeneGRIPAP1chrX:48791736chrX:48855916ENST00000376425Q4V328025208_64114.0811.0Coiled coilOntology_term=ECO:0000255
TgeneGRIPAP1chrX:48791736chrX:48855916ENST00000376425Q4V328025701_73514.0811.0Coiled coilOntology_term=ECO:0000255
TgeneGRIPAP1chrX:48791736chrX:48855916ENST00000376425Q4V328025785_81414.0811.0Coiled coilOntology_term=ECO:0000255
TgeneGRIPAP1chrX:48814242chrX:48855916ENST00000376425Q4V328025208_64114.0811.0Coiled coilOntology_term=ECO:0000255
TgeneGRIPAP1chrX:48814242chrX:48855916ENST00000376425Q4V328025701_73514.0811.0Coiled coilOntology_term=ECO:0000255
TgeneGRIPAP1chrX:48814242chrX:48855916ENST00000376425Q4V328025785_81414.0811.0Coiled coilOntology_term=ECO:0000255
TgeneGRIPAP1chrX:48791736chrX:48855916ENST00000376425Q4V328025682_69414.0811.0Compositional biasLow complexity
TgeneGRIPAP1chrX:48814242chrX:48855916ENST00000376425Q4V328025682_69414.0811.0Compositional biasLow complexity
TgeneGRIPAP1chrX:48791736chrX:48855916ENST00000376425Q4V328025532_55114.0811.0RegionDisordered
TgeneGRIPAP1chrX:48791736chrX:48855916ENST00000376425Q4V328025558_58014.0811.0RegionDisordered
TgeneGRIPAP1chrX:48791736chrX:48855916ENST00000376425Q4V328025681_70614.0811.0RegionDisordered
TgeneGRIPAP1chrX:48814242chrX:48855916ENST00000376425Q4V328025532_55114.0811.0RegionDisordered
TgeneGRIPAP1chrX:48814242chrX:48855916ENST00000376425Q4V328025558_58014.0811.0RegionDisordered
TgeneGRIPAP1chrX:48814242chrX:48855916ENST00000376425Q4V328025681_70614.0811.0RegionDisordered

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOTUD5chrX:48791736chrX:48855916ENST00000156084Q96G7459430_443358.0572.0Compositional biasLow complexity
HgeneOTUD5chrX:48791736chrX:48855916ENST00000156084Q96G7459450_462358.0572.0Compositional biasLow complexity
HgeneOTUD5chrX:48814242chrX:48855916ENST00000156084Q96G7419430_443198.0572.0Compositional biasLow complexity
HgeneOTUD5chrX:48814242chrX:48855916ENST00000156084Q96G7419450_462198.0572.0Compositional biasLow complexity
HgeneOTUD5chrX:48814242chrX:48855916ENST00000156084Q96G7419213_341198.0572.0DomainOTU
HgeneOTUD5chrX:48791736chrX:48855916ENST00000156084Q96G7459418_502358.0572.0RegionDisordered
HgeneOTUD5chrX:48814242chrX:48855916ENST00000156084Q96G7419218_224198.0572.0RegionCys-loop
HgeneOTUD5chrX:48814242chrX:48855916ENST00000156084Q96G7419273_283198.0572.0RegionVariable-loop
HgeneOTUD5chrX:48814242chrX:48855916ENST00000156084Q96G7419329_334198.0572.0RegionHis-loop
HgeneOTUD5chrX:48814242chrX:48855916ENST00000156084Q96G7419418_502198.0572.0RegionDisordered
TgeneGRIPAP1chrX:48791736chrX:48855916ENST00000376425Q4V3280254_16114.0811.0Coiled coilOntology_term=ECO:0000255
TgeneGRIPAP1chrX:48814242chrX:48855916ENST00000376425Q4V3280254_16114.0811.0Coiled coilOntology_term=ECO:0000255


check button - Retained PPIs in in-frame fusion.
PartnerHgeneHbpTgeneTbpENSTUniProtStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerHgeneHbpTgeneTbpENSTUniProtStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Fusion Transcript Sequence for OTUD5_GRIPAP1

check button In-frame Fusion Transcript Sequences.

check button N-Truncated Transcript (5UTR-3CDS) Sequences

check button C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for OTUD5_GRIPAP1

check button In-frame Fusion Protein Sequences.

check button N-Truncated Protein (5UTR-3CDS) Sequences

check button C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for OTUD5_GRIPAP1


check button TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences
NumGene GroupDomain LociFusion Protein IDFusion Gene NamePartnerMutated Residue in WT ProteinSeq. LengthMutated Residue in Fusion Protein

check button CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

NumGene GroupDomain LociFusion Protein IDFusion Gene NamePartnerMutated Residue in WT ProteinSeq. LengthMutated Residue in Fusion Protein

check button TCGA All Mutated Fusion Protein Sequences


Fusion Protein IDSample IDMutated PartnerAAchange in WTSeq. LengthAAchange in Fusion

check button CCLE All Mutated Fusion Protein Sequences


Fusion Protein IDSample IDMutated PartnerAAchange in WTSeq. LengthAAchange in Fusion

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Fusion Gene Exprssed Samples for OTUD5_GRIPAP1


check buttonRNA-seq based fusion gene expressed samples.
SourceStudyDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
CCLEInvasive Breast CarcinomaKPL1OTUD5

chrX

48791737-GRIPAP1

chrX

48855916

-
ChimerDBLIHCTCGA-2Y-A9GZ-01AOTUD5

chrX

48814242-GRIPAP1

chrX

48855916

-
cBioPortalCCLE_BROAD_2019MIXEDKPL1_BREASTOTUD5

chrX

48791737GRIPAP1

chrX

48855916


check buttonDNA-seq based fusion gene expressed samples.
SourceStudyDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrandSV type


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Related Drugs for OTUD5_GRIPAP1


check button PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.
PMIDFusion Gene NameDrugStudy Title

check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status