Home

Download

Statistics

Examples

About

Contact

	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:KIF16B_PLCB1 (FusionGDB2 ID:HG55614TG23236)

Fusion Gene Summary for KIF16B_PLCB1

Fusion gene summary

Fusion gene information	Fusion gene name: KIF16B_PLCB1
	Fusion gene ID: hg55614tg23236
		Hgene	Tgene
	Gene symbol	KIF16B	PLCB1
	Gene ID	55614	23236
	Gene name	kinesin family member 16B	phospholipase C beta 1
	Synonyms	C20orf23\|KISC20ORF\|SNX23	DEE12\|EIEE12\|PI-PLC\|PLC-154\|PLC-I\|PLC-beta-1\|PLC154\|PLCB1A\|PLCB1B
	Cytomap	20p12.1	20p12.3
	Type of gene	protein-coding	protein-coding
	Description	kinesin-like protein KIF16Bkinesin motor proteinsorting nexin 23testis secretory sperm-binding protein Li 201a	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-11-phosphatidyl-D-myo-inositol-4,5-bisphosphateinositoltrisphosphohydrolasemonophosphatidylinositol phosphodiesterasephosphoinositidase Cphosphoinositide phospholipase Cphospholipase C,
	Modification date	20240305	20240416
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000354981, ENST00000355755, ENST00000408042, ENST00000378003,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 9 X 15 X 9=1215	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 5 X 27 X 10=1350
	# samples	17	30
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(17/121510)=-2.83734966235544 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(30/135010)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KIF16B [Title/Abstract] AND PLCB1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KIF16B(16553873)-PLCB1(8665578), # samples:1

Top

Fusion Gene Breakpoints for KIF16B_PLCB1

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
KIF16B	chr20	16553873	PLCB1	chr20	16553873
KIF16B	chr20	16553873	PLCB1	chr20	8665578
KIF16B	chr20	16553874	PLCB1	chr20	8665579
KIF16B	chr20	16573229	PLCB1	chr20	8684932

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

Top

Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for KIF16B_PLCB1

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
KIF16B-PLCB1	Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions M1		KIF16B kinesin motor couples to phospholipase C beta 1, coordinating endosomal trafficking with Gq-coupled calcium/IP3 signaling.		PLC pathway blockers; kinesin inhibitors		Carcinomas and neuroendocrine tumors

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
KIF16B-PLCB1	Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions M1		KIF16B kinesin motor couples to phospholipase C beta 1, coordinating endosomal trafficking with Gq-coupled calcium/IP3 signaling.	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 34580062; Title: A PLCB1-PI3K-AKT Signaling Axis Activates EMT to Promote Cholangiocarcinoma Progression.	PLC pathway blockers; kinesin inhibitors		Carcinomas and neuroendocrine tumors	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 34580062; Title: A PLCB1-PI3K-AKT Signaling Axis Activates EMT to Promote Cholangiocarcinoma Progression.; PMID: 37208557; Title: PLCB1 Enhances Cell Migration and Invasion in Gastric Cancer Via Regulating Actin Cytoskeletal Remodeling and Epithelial-Mesenchymal Transition.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PLCB1	GO:0035722	interleukin-12-mediated signaling pathway	11743656
Tgene	PLCB1	GO:0035723	interleukin-15-mediated signaling pathway	11743656
Tgene	PLCB1	GO:0046330	positive regulation of JNK cascade	9500449
Tgene	PLCB1	GO:0046488	phosphatidylinositol metabolic process	9188725
Tgene	PLCB1	GO:0070498	interleukin-1-mediated signaling pathway	8872139

Top

Fusion Genomic Features for KIF16B_PLCB1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
KIF16B	chr20	16553873	-	PLCB1	chr20	8665578	+	1.07e-03	9.99e-01

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
KIF16B	chr20	16553873	-	PLCB1	chr20	8665578	+	1.07e-03	9.99e-01

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

Top

Fusion Gene ORF Annotations for KIF16B_PLCB1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000378003	ENST00000338037	KIF16B	chr20	16553873	-	PLCB1	chr20	8665578	+
5UTR-3CDS	ENST00000378003	ENST00000378637	KIF16B	chr20	16553873	-	PLCB1	chr20	8665578	+
5UTR-3CDS	ENST00000378003	ENST00000378641	KIF16B	chr20	16553873	-	PLCB1	chr20	8665578	+
Frame-shift	ENST00000354981	ENST00000338037	KIF16B	chr20	16553873	-	PLCB1	chr20	8665578	+
Frame-shift	ENST00000354981	ENST00000378637	KIF16B	chr20	16553873	-	PLCB1	chr20	8665578	+
Frame-shift	ENST00000354981	ENST00000378641	KIF16B	chr20	16553873	-	PLCB1	chr20	8665578	+
Frame-shift	ENST00000355755	ENST00000338037	KIF16B	chr20	16553873	-	PLCB1	chr20	8665578	+
Frame-shift	ENST00000355755	ENST00000378637	KIF16B	chr20	16553873	-	PLCB1	chr20	8665578	+
Frame-shift	ENST00000355755	ENST00000378641	KIF16B	chr20	16553873	-	PLCB1	chr20	8665578	+
Frame-shift	ENST00000408042	ENST00000338037	KIF16B	chr20	16553873	-	PLCB1	chr20	8665578	+
Frame-shift	ENST00000408042	ENST00000378637	KIF16B	chr20	16553873	-	PLCB1	chr20	8665578	+
Frame-shift	ENST00000408042	ENST00000378641	KIF16B	chr20	16553873	-	PLCB1	chr20	8665578	+

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000378003	ENST00000338037	KIF16B	chr20	16553873	PLCB1	chr20	8665578	0	534
ENST00000378003	ENST00000378637	KIF16B	chr20	16553873	PLCB1	chr20	8665578	0	921
ENST00000378003	ENST00000378641	KIF16B	chr20	16553873	PLCB1	chr20	8665578	0	878

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000378003	ENST00000338037	KIF16B	chr20	16553873	PLCB1	chr20	8665578	0.00e+00	8.48e-06
ENST00000378003	ENST00000378637	KIF16B	chr20	16553873	PLCB1	chr20	8665578	0.00e+00	1.13e-05
ENST00000378003	ENST00000378641	KIF16B	chr20	16553873	PLCB1	chr20	8665578	0.00e+00	1.36e-05

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

Top

Fusion Protein Retained/Non-Retained Functional Features for KIF16B_PLCB1

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Fusion Transcript Sequence for KIF16B_PLCB1

In-frame Fusion Transcript Sequences.

N-Truncated Transcript (5UTR-3CDS) Sequences

>KIF16B_PLCB1_ENST00000378003_ENST00000338037_16553873_8665578 length=5840nt 
 Breakpoint=0nt
GACAAATATCAGTGGATGGGTTCATGCGCTATCTGAGTGGAGAAGAAAACGGAGTCGTTTCACCTGAGAAACTGGATTTGAATGAAGACATGTCTCAGCCCCTTTCTCACTATTTCATTAATTCCTCGCACAACACCTACCTCACAGCTG
GCCAACTGGCTGGAAACTCCTCTGTTGAGATGTATCGCCAAGTGCTCCTGTCTGGTTGTCGCTGTGTGGAGCTGGACTGCTGGAAGGGACGGACTGCAGAAGAGGAACCTGTCATCACCCATGGCTTCACCATGACAACTGAAATATCTT
TCAAGGAAGTGATAGAAGCAATTGCGGAGTGTGCATTTAAGACTTCACCTTTTCCAATTCTCCTTTCGTTTGAGAACCATGTGGATTCCCCAAAGCAGCAAGCCAAGATGGCGGAGTACTGCCGACTGATCTTTGGGGATGCCCTTCTCA
TGGAGCCCCTGGAAAAATATCCACTGGAATCTGGAGTTCCTCTTCCAAGCCCTATGGATTTAATGTATAAAATTTTGGTGAAAAATAAGAAGAAATCACACAAGTCATCAGAAGGAAGCGGCAAAAAGAAGCTCTCAGAACAAGCCTCCA
ACACCTACAGTGACTCCTCCAGCATGTTCGAGCCCTCATCCCCAGGAGCCGGAGAAGCTGATACGGAAAGTGACGACGACGATGATGATGATGACTGTAAAAAATCTTCAATGGATGAGGGGACTGCTGGAAGTGAGGCTATGGCCACAG
AAGAAATGTCTAATCTGGTGAACTATATTCAGCCAGTCAAGTTTGAGTCATTTGAAATTTCAAAAAAAAGAAATAAAAGTTTTGAAATGTCTTCCTTCGTGGAAACCAAAGGACTTGAACAACTCACCAAGTCTCCAGTGGAATTTGTAG
AATATAACAAAATGCAGCTTAGCAGGATATATCCAAAAGGAACACGTGTGGATTCATCCAACTATATGCCTCAGCTCTTCTGGAATGCAGGTTGTCAGATGGTGGCACTTAATTTCCAGACAATGGACCTGGCTATGCAAATAAATATGG
GGATGTATGAATACAACGGGAAGAGTGGCTACAGATTGAAGCCAGAGTTCATGAGGAGGCCTGACAAGCATTTTGATCCATTTACTGAAGGCATCGTAGATGGGATAGTGGCAAACACTTTGTCTGTTAAGATTATTTCAGGTCAGTTTC
TTTCTGATAAGAAAGTTGGGACTTACGTGGAAGTAGATATGTTTGGTTTGCCTGTGGATACAAGGAGGAAGGCATTTAAGACCAAAACATCCCAAGGAAATGCTGTGAATCCTGTCTGGGAAGAAGAACCTATTGTGTTCAAAAAGGTGG
TTCTTCCTACTCTGGCCTGTTTGAGAATAGCAGTTTATGAAGAAGGAGGTAAATTCATTGGCCACCGTATCTTGCCAGTGCAAGCCATTCGGCCAGGCTATCACTATATCTGTCTAAGGAATGAAAGGAACCAGCCTCTGACGCTGCCTG
CTGTCTTTGTCTACATAGAAGTGAAAGACTATGTGCCAGACACATATGCAGATGTCATCGAAGCTTTATCAAACCCAATCCGATATGTGAACCTGATGGAACAGAGAGCTAAGCAATTGGCTGCTTTGACACTGGAAGATGAAGAAGAAG
TAAAGAAAGAGGCTGATCCTGGAGAAACACCATCAGAGGCTCCAAGTGAAGCGAGAACGACTCCAGCAGAAAATGGGGTGAATCACACTACAACCCTGACACCCAAGCCACCCTCCCAGGCTCTCCACAGCCAGCCAGCTCCAGGTTCTG
TAAAGGCACCTGCCAAAACAGAAGATCTTATTCAGAGTGTCTTAACAGAAGTGGAAGCACAGACCATCGAAGAACTAAAGCAACAGAAATCGTTTGTGAAACTTCAAAAGAAACACTACAAAGAAATGAAAGACCTGGTTAAGAGACACC
ACAAGAAAACCACTGACCTTATCAAAGAACACACTACCAAGTATAATGAAATTCAGAATGACTACTTGAGAAGGAGAGCCGCTTTGGAAAAGTCCGCCAAAAAGGACAGTAAGAAAAAATCGGAACCCAGCAGCCCTGATCATGGTTCAT
CAACGATTGAGCAAGACCTCGCTGCTCTGGATGCTGAAATGACCCAAAAGTTAATAGACTTGAAGGACAAACAACAGCAGCAGCTGCTTAATCTTCGGCAAGAACAGTATTATAGTGAAAAATACCAGAAGCGAGAACATATTAAACTGC
TTATTCAAAAGTTGACGGATGTCGCAGAAGAGTGTCAGAACAATCAGTTAAAGAAGCTCAAAGAAATCTGTGAGAAAGAAAAGAAAGAATTAAAGAAGAAAATGGATAAAAAGAGGCAGGAGAAGATAACAGAAGCTAAATCCAAAGACA
AAAGTCAGATGGAAGAGGAGAAGACAGAGATGATCCGGTCATATATCCAGGAAGTGGTGCAGTATATCAAGAGGCTAGAAGAAGCGCAAAGTAAACGGCAAGAAAAACTCGTAGAGAAACACAAGGAAATACGTCAGCAGATCCTGGATG
AAAAGCCCAAGCTGCAGGTGGAGCTGGAGCAAGAATACCAAGACAAATTCAAAAGACTGCCCCTCGAGATTTTGGAATTCGTGCAGGAAGCCATGAAAGGAAAGATCAGTGAAGACAGCAATCACGGTTCTGCCCCTCTCTCCCTGTCCT
CAGACCCTGGAAAAGTGAACCACAAGACTCCCTCCAGTGAGGAGCTGGGAGGAGACATCCCAGGAAAAGAATTTGATACTCCTCTGTGAATGCTCCTGCCAGGCCTTCAGAAATTGCATGGCCACTCCAGCGTCATCGGACTCTCTCTTA
TTACAAAGATCACTGCCCAGGACCATCTTCCCGAGAAGCATCCCTTAGCCTAAAATCCACACCAAAGGGAGAGTTCCAGAGGAATCCATGAAGAATTCCCATGCCCAGGCTCCATGTGTCATGTGGAAACCTCCACAGGTCTGCTAGTGA
AGAATGCATGTATGTGAGATTTTTGTTTTCTTTCCAATAGCAAATTCAAAGCAAGCAACTTGCAGGCTCCATGGAACTTTTAATGAAGGACAGTGTCTTCTTTGAAGAAAATCAAGCTCGTGTTTTTATTCGAAGCTCTGGTGTAAAATA
TTTCAAAGTCATAGAAATAGTTTGAGAAATGCATAGCATTATTTAACACTATTGAACAGCCGACTTTGAGCATTGTTTCTTCTAACTGCCCCTCAACTACCATTATCTTCAAGTCAACATGCATATTACATTTTCATCCTTTGCTTTGCA
AGCACTGGTGGCTTGCAGTTTGCTAATTTATTTATCATAGAGTCATCAATGTATTTGTTGCTGACATGGTTTTATTAGATACTGTAGTGATTCAAATAAGTTTTCTATTTGAAAAAAAAAATCACTTGATTGTATCCTTGCCCAGTGAAG
CCATCCTAAGACTTAGCAATATGGATTGTACATTTGGCTGCATGAGCAAGTCGGCCGCACACTTCCAGACAGTGTGCTGTTTGAATTGACTATTTGCACTCAAAGTCTGGGTATTCATTGGTTATTGGCCTGAAATGATCAAATAACTAC
AAATGATCTGTTGAATAAAAATAGTTGAGCTGATATATGTTAAGCAGATATTCAATCAGAATGAACAGGTTCCGGTGGTTATTTTGCCGTTTGACATTTTTTATGGTTCATTTATTTTTAATATAGAGAGGAAGATTGAATATTTATCTA
GAGAATACAAAGACCCACATGTAAATGATAGGTATTATCTCCATGTATATATGTACCCACTTAGTCATGTAAGTGCATATACACATACACACACATGAGTGTAGACATGTGTTTATTAATTGACAATGACCCAAATCTCTTCCACAAGAC
TTAAAACCAAATTCAGGGACAAATGGATAGAGAAGAAAAGGGTCAAACATCGAGATTACATGGATGTTAAATTATATGGAGACGCTAAGAAATAATTGATGGAGCCATTGATGCAAACCGAAGTAGATTTAGAACTTATATGAATTTGAT
TTATATTTTGCAAGATCAAAAATTAGATGTTAAGTATCAGATTTTAAGCTTGTTTTAATGGTCAAAAAATTAGGACAGAAATAATATGGACATTTATTAGTATCTTCCATAATTTTTAAGTCTGACACATTTCTATTTTATTCTAACATA
AAAAAACTTCCATTATATATTTACTAAGTATATTTAATTCACTTAACTCTGTCTTTATAAGTTCCTATTTTAGATGGAATAAGAGAAACAAATTATATCAAGGTAAAACTGATCAAAAGCATAATTGAAAGTTCTGAAAAAAGAAAAATA
ATAATATGTAGAAAAATGTAACTTAGAGAGTAACACATGAACATTGAAGTTAAAACCCAGAAGCCAGATGCTCACAGTTTTATTTTACTTTAAAATAAACCTGTCTGACTGTAGCTTTGTGAAATATCTTAAAACGCAAAAACCAATTGT
GTCCTGAAAATTGTTTCAAGAATTTAATATTTTTATGAAAATTATTTTATTTAACTTTAAGCAATAACTAGAGATTACAATTAAATTTTAATCAAAATGAAGGCTTAGTTCAAACATAAGGAAACAGTGTTTGATTAAAAAAAACACATC
TAGTAAGACGTAAGGGGAAAATCACATCCTCTTTGGAGATGATTATATTTTGATCTGAAGGGTTTGGGGTGTTCATTAGACACTTAATAAAACTTAACTTCCAATGAAAAAGAAATCTTTTGTAAATCATTCTACTTTTGCACTTTGAAA
GAAAGGCGTTAATCATAAAGAAGCAAGAATGGTCAAAATCGAATGCTGCATTTTTATAAACAAAATTACAGACTGTCTGAAATTGAAGAAGAATGAACTAATAATAGCATTCATAACCAAACACAATGATGATTATTGCAGAACATTGTA
TCACATTTTAGTCCAGAGATAGAATAAAGTTGAATAACCTTGACTTACACAAAACTGTTTTGGTAGTTGGATTTCATTATCTTAGTGAATTTAGTCATTTTACAATATGTTTGTATTTGGCCATTTACTGTAATCACATTTTTATATCTG
TACAATGACACTTTTTGCAGTTGTGGGGTAGTGTGTAACACTGTCCATCTTGCATCATTGAAACTACTACAATGATACTATCATTTAATAATATTAATATTACTTGAAATAGACTAAGATAAAGAAAAGGGGTCTGTATGATGTGCAGTT
TTGTGCCTTTATGTATTTGCCTTGTTCTTTGTCGAATGTGTGAAATTCCGTACTGTGGTTTTTCCTATAATAGAAAGTAGAGCTGTGTATTAAATTAGACTGTGTCTCTCTGATACCTTTACACTACTGAGAATAGCATGGTTTTGGCCA
TGTAAACCAATTTTCAAAGTTCTAATGACATAGCCATGTGTTTTTGGTTTTTTATATTTCATTTTAAAATTTGAGTATCACCATACATTAATTAATACTCCTGTAGTAGATAAGCTGTCATTAAGTAATTCCCAAAAAAAGGGCCATTTG
CTTGCATTACTTTGAATTTAATGTTGCGCTTGTGCACTGTGTTAATATTGTTTGTGATGGATTGGACGTTGTGACTCTTGCCTTTTAAGAAGAAAAAAAAGATAGGACAAAGTATTTGAAGCTCTTAAAATGTACATATTTTGGTTCTTC
TATCTCAAATTATTTAAAATGCATAATTCACATTTTTGTAATAATTCTATGCAATTTTGTGGCATGATGTTTCTTCCACTTGTAATTTTATGTGCTTTCATCACAAATCCAAAGGAAAGAATAAAAATTTCTTAACACAA

>KIF16B_PLCB1_ENST00000378003_ENST00000378637_16553873_8665578 length=2989nt 
 Breakpoint=0nt
GACAAATATCAGTGGATGGGTTCATGCGCTATCTGAGTGGAGAAGAAAACGGAGTCGTTTCACCTGAGAAACTGGATTTGAATGAAGACATGTCTCAGCCCCTTTCTCACTATTTCATTAATTCCTCGCACAACACCTACCTCACAGCTG
GCCAACTGGCTGGAAACTCCTCTGTTGAGATGTATCGCCAAGTGCTCCTGTCTGGTTGTCGCTGTGTGGAGCTGGACTGCTGGAAGGGACGGACTGCAGAAGAGGAACCTGTCATCACCCATGGCTTCACCATGACAACTGAAATATCTT
TCAAGGAAGTGATAGAAGCAATTGCGGAGTGTGCATTTAAGACTTCACCTTTTCCAATTCTCCTTTCGTTTGAGAACCATGTGGATTCCCCAAAGCAGCAAGCCAAGATGGCGGAGTACTGCCGACTGATCTTTGGGGATGCCCTTCTCA
TGGAGCCCCTGGAAAAATATCCACTGGAATCTGGAGTTCCTCTTCCAAGCCCTATGGATTTAATGTATAAAATTTTGGTGAAAAATAAGAAGAAATCACACAAGTCATCAGAAGGAAGCGGCAAAAAGAAGCTCTCAGAACAAGCCTCCA
ACACCTACAGTGACTCCTCCAGCATGTTCGAGCCCTCATCCCCAGGAGCCGGAGAAGCTGATACGGAAAGTGACGACGACGATGATGATGATGACTGTAAAAAATCTTCAATGGATGAGGGGACTGCTGGAAGTGAGGCTATGGCCACAG
AAGAAATGTCTAATCTGGTGAACTATATTCAGCCAGTCAAGTTTGAGTCATTTGAAATTTCAAAAAAAAGAAATAAAAGTTTTGAAATGTCTTCCTTCGTGGAAACCAAAGGACTTGAACAACTCACCAAGTCTCCAGTGGAATTTGTAG
AATATAACAAAATGCAGCTTAGCAGGATATATCCAAAAGGAACACGTGTGGATTCATCCAACTATATGCCTCAGCTCTTCTGGAATGCAGGTTGTCAGATGGTGGCACTTAATTTCCAGACAATGGACCTGGCTATGCAAATAAATATGG
GGATGTATGAATACAACGGGAAGAGTGGCTACAGATTGAAGCCAGAGTTCATGAGGAGGCCTGACAAGCATTTTGATCCATTTACTGAAGGCATCGTAGATGGGATAGTGGCAAACACTTTGTCTGTTAAGATTATTTCAGGTCAGTTTC
TTTCTGATAAGAAAGTTGGGACTTACGTGGAAGTAGATATGTTTGGTTTGCCTGTGGATACAAGGAGGAAGGCATTTAAGACCAAAACATCCCAAGGAAATGCTGTGAATCCTGTCTGGGAAGAAGAACCTATTGTGTTCAAAAAGGTGG
TTCTTCCTACTCTGGCCTGTTTGAGAATAGCAGTTTATGAAGAAGGAGGTAAATTCATTGGCCACCGTATCTTGCCAGTGCAAGCCATTCGGCCAGGCTATCACTATATCTGTCTAAGGAATGAAAGGAACCAGCCTCTGACGCTGCCTG
CTGTCTTTGTCTACATAGAAGTGAAAGACTATGTGCCAGACACATATGCAGATGTCATCGAAGCTTTATCAAACCCAATCCGATATGTGAACCTGATGGAACAGAGAGCTAAGCAATTGGCTGCTTTGACACTGGAAGATGAAGAAGAAG
TAAAGAAAGAGGCTGATCCTGGAGAAACACCATCAGAGGCTCCAAGTGAAGCGAGAACGACTCCAGCAGAAAATGGGGTGAATCACACTACAACCCTGACACCCAAGCCACCCTCCCAGGCTCTCCACAGCCAGCCAGCTCCAGGTTCTG
TAAAGGCACCTGCCAAAACAGAAGATCTTATTCAGAGTGTCTTAACAGAAGTGGAAGCACAGACCATCGAAGAACTAAAGCAACAGAAATCGTTTGTGAAACTTCAAAAGAAACACTACAAAGAAATGAAAGACCTGGTTAAGAGACACC
ACAAGAAAACCACTGACCTTATCAAAGAACACACTACCAAGTATAATGAAATTCAGAATGACTACTTGAGAAGGAGAGCCGCTTTGGAAAAGTCCGCCAAAAAGGACAGTAAGAAAAAATCGGAACCCAGCAGCCCTGATCATGGTTCAT
CAACGATTGAGCAAGACCTCGCTGCTCTGGATGCTGAAATGACCCAAAAGTTAATAGACTTGAAGGACAAACAACAGCAGCAGCTGCTTAATCTTCGGCAAGAACAGTATTATAGTGAAAAATACCAGAAGCGAGAACATATTAAACTGC
TTATTCAAAAGTTGACGGATGTCGCAGAAGAGTGTCAGAACAATCAGTTAAAGAAGCTCAAAGAAATCTGTGAGAAAGAAAAGAAAGAATTAAAGAAGAAAATGGATAAAAAGAGGCAGGAGAAGATAACAGAAGCTAAATCCAAAGACA
AAAGTCAGATGGAAGAGGAGAAGACAGAGATGATCCGGTCATATATCCAGGAAGTGGTGCAGTATATCAAGAGGCTAGAAGAAGCGCAAAGTAAACGGCAAGAAAAACTCGTAGAGAAACACAAGGAAATACGTCAGCAGATCCTGGATG
AAAAGCCCAAGGGGGAAGGTTCCTCCTCATTCTTGTCGGAAACTTGCCATGAGGATCCCTCTGTTTCCCCCAACTTTACTCCCCCCAACCCTCAAGCTCTCAAGTGGTGACCACCGTCCTTCCGGCCAGGTAGGACTGGATGGGAGGGGT
CGCTTTTGAGAGAAGGGTGGTGTGTAGCCATCCAGTTTTCAGGCATCACGGACTTGCTCGTTTGTCCTTCATCCTCCCTTTCTCTACATTCCCATCTTTTTTTTCTGCTAAAGTTCCCAGCCACACCCATGATCATTTCCTCATCCTTTC
TGCCTTCCTCTGGTATTAATTTCTCCATCATTGTGCTCTCTCTTCCTGACATAAATCTCATTCTTCCATATTGTCTTCTTCCTCTTTCTCCATTTTGTTTCTCTATTGGCAAATTTGGCTTCCTTTTTAATCTGGATTT

>KIF16B_PLCB1_ENST00000378003_ENST00000378641_16553873_8665578 length=5958nt 
 Breakpoint=0nt
GACAAATATCAGTGGATGGGTTCATGCGCTATCTGAGTGGAGAAGAAAACGGAGTCGTTTCACCTGAGAAACTGGATTTGAATGAAGACATGTCTCAGCCCCTTTCTCACTATTTCATTAATTCCTCGCACAACACCTACCTCACAGCTG
GCCAACTGGCTGGAAACTCCTCTGTTGAGATGTATCGCCAAGTGCTCCTGTCTGGTTGTCGCTGTGTGGAGCTGGACTGCTGGAAGGGACGGACTGCAGAAGAGGAACCTGTCATCACCCATGGCTTCACCATGACAACTGAAATATCTT
TCAAGGAAGTGATAGAAGCAATTGCGGAGTGTGCATTTAAGACTTCACCTTTTCCAATTCTCCTTTCGTTTGAGAACCATGTGGATTCCCCAAAGCAGCAAGCCAAGATGGCGGAGTACTGCCGACTGATCTTTGGGGATGCCCTTCTCA
TGGAGCCCCTGGAAAAATATCCACTGGAATCTGGAGTTCCTCTTCCAAGCCCTATGGATTTAATGTATAAAATTTTGGTGAAAAATAAGAAGAAATCACACAAGTCATCAGAAGGAAGCGGCAAAAAGAAGCTCTCAGAACAAGCCTCCA
ACACCTACAGTGACTCCTCCAGCATGTTCGAGCCCTCATCCCCAGGAGCCGGAGAAGCTGATACGGAAAGTGACGACGACGATGATGATGATGACTGTAAAAAATCTTCAATGGATGAGGGGACTGCTGGAAGTGAGGCTATGGCCACAG
AAGAAATGTCTAATCTGGTGAACTATATTCAGCCAGTCAAGTTTGAGTCATTTGAAATTTCAAAAAAAAGAAATAAAAGTTTTGAAATGTCTTCCTTCGTGGAAACCAAAGGACTTGAACAACTCACCAAGTCTCCAGTGGAATTTGTAG
AATATAACAAAATGCAGCTTAGCAGGATATATCCAAAAGGAACACGTGTGGATTCATCCAACTATATGCCTCAGCTCTTCTGGAATGCAGGTTGTCAGATGGTGGCACTTAATTTCCAGACAATGGACCTGGCTATGCAAATAAATATGG
GGATGTATGAATACAACGGGAAGAGTGGCTACAGATTGAAGCCAGAGTTCATGAGGAGGCCTGACAAGCATTTTGATCCATTTACTGAAGGCATCGTAGATGGGATAGTGGCAAACACTTTGTCTGTTAAGATTATTTCAGGTCAGTTTC
TTTCTGATAAGAAAGTTGGGACTTACGTGGAAGTAGATATGTTTGGTTTGCCTGTGGATACAAGGAGGAAGGCATTTAAGACCAAAACATCCCAAGGAAATGCTGTGAATCCTGTCTGGGAAGAAGAACCTATTGTGTTCAAAAAGGTGG
TTCTTCCTACTCTGGCCTGTTTGAGAATAGCAGTTTATGAAGAAGGAGGTAAATTCATTGGCCACCGTATCTTGCCAGTGCAAGCCATTCGGCCAGGCTATCACTATATCTGTCTAAGGAATGAAAGGAACCAGCCTCTGACGCTGCCTG
CTGTCTTTGTCTACATAGAAGTGAAAGACTATGTGCCAGACACATATGCAGATGTCATCGAAGCTTTATCAAACCCAATCCGATATGTGAACCTGATGGAACAGAGAGCTAAGCAATTGGCTGCTTTGACACTGGAAGATGAAGAAGAAG
TAAAGAAAGAGGCTGATCCTGGAGAAACACCATCAGAGGCTCCAAGTGAAGCGAGAACGACTCCAGCAGAAAATGGGGTGAATCACACTACAACCCTGACACCCAAGCCACCCTCCCAGGCTCTCCACAGCCAGCCAGCTCCAGGTTCTG
TAAAGGCACCTGCCAAAACAGAAGATCTTATTCAGAGTGTCTTAACAGAAGTGGAAGCACAGACCATCGAAGAACTAAAGCAACAGAAATCGTTTGTGAAACTTCAAAAGAAACACTACAAAGAAATGAAAGACCTGGTTAAGAGACACC
ACAAGAAAACCACTGACCTTATCAAAGAACACACTACCAAGTATAATGAAATTCAGAATGACTACTTGAGAAGGAGAGCCGCTTTGGAAAAGTCCGCCAAAAAGGACAGTAAGAAAAAATCGGAACCCAGCAGCCCTGATCATGGTTCAT
CAACGATTGAGCAAGACCTCGCTGCTCTGGATGCTGAAATGACCCAAAAGTTAATAGACTTGAAGGACAAACAACAGCAGCAGCTGCTTAATCTTCGGCAAGAACAGTATTATAGTGAAAAATACCAGAAGCGAGAACATATTAAACTGC
TTATTCAAAAGTTGACGGATGTCGCAGAAGAGTGTCAGAACAATCAGTTAAAGAAGCTCAAAGAAATCTGTGAGAAAGAAAAGAAAGAATTAAAGAAGAAAATGGATAAAAAGAGGCAGGAGAAGATAACAGAAGCTAAATCCAAAGACA
AAAGTCAGATGGAAGAGGAGAAGACAGAGATGATCCGGTCATATATCCAGGAAGTGGTGCAGTATATCAAGAGGCTAGAAGAAGCGCAAAGTAAACGGCAAGAAAAACTCGTAGAGAAACACAAGGAAATACGTCAGCAGATCCTGGATG
AAAAGCCCAAGGGGGAAGGTTCCTCCTCATTCTTGTCGGAAACTTGCCATGAGGATCCCTCTGTTTCCCCCAACTTTACTCCCCCCAACCCTCAAGCTCTCAAGTGGTGACCACCGTCCTTCCGGCCAGCTGCAGGTGGAGCTGGAGCAA
GAATACCAAGACAAATTCAAAAGACTGCCCCTCGAGATTTTGGAATTCGTGCAGGAAGCCATGAAAGGAAAGATCAGTGAAGACAGCAATCACGGTTCTGCCCCTCTCTCCCTGTCCTCAGACCCTGGAAAAGTGAACCACAAGACTCCC
TCCAGTGAGGAGCTGGGAGGAGACATCCCAGGAAAAGAATTTGATACTCCTCTGTGAATGCTCCTGCCAGGCCTTCAGAAATTGCATGGCCACTCCAGCGTCATCGGACTCTCTCTTATTACAAAGATCACTGCCCAGGACCATCTTCCC
GAGAAGCATCCCTTAGCCTAAAATCCACACCAAAGGGAGAGTTCCAGAGGAATCCATGAAGAATTCCCATGCCCAGGCTCCATGTGTCATGTGGAAACCTCCACAGGTCTGCTAGTGAAGAATGCATGTATGTGAGATTTTTGTTTTCTT
TCCAATAGCAAATTCAAAGCAAGCAACTTGCAGGCTCCATGGAACTTTTAATGAAGGACAGTGTCTTCTTTGAAGAAAATCAAGCTCGTGTTTTTATTCGAAGCTCTGGTGTAAAATATTTCAAAGTCATAGAAATAGTTTGAGAAATGC
ATAGCATTATTTAACACTATTGAACAGCCGACTTTGAGCATTGTTTCTTCTAACTGCCCCTCAACTACCATTATCTTCAAGTCAACATGCATATTACATTTTCATCCTTTGCTTTGCAAGCACTGGTGGCTTGCAGTTTGCTAATTTATT
TATCATAGAGTCATCAATGTATTTGTTGCTGACATGGTTTTATTAGATACTGTAGTGATTCAAATAAGTTTTCTATTTGAAAAAAAAAATCACTTGATTGTATCCTTGCCCAGTGAAGCCATCCTAAGACTTAGCAATATGGATTGTACA
TTTGGCTGCATGAGCAAGTCGGCCGCACACTTCCAGACAGTGTGCTGTTTGAATTGACTATTTGCACTCAAAGTCTGGGTATTCATTGGTTATTGGCCTGAAATGATCAAATAACTACAAATGATCTGTTGAATAAAAATAGTTGAGCTG
ATATATGTTAAGCAGATATTCAATCAGAATGAACAGGTTCCGGTGGTTATTTTGCCGTTTGACATTTTTTATGGTTCATTTATTTTTAATATAGAGAGGAAGATTGAATATTTATCTAGAGAATACAAAGACCCACATGTAAATGATAGG
TATTATCTCCATGTATATATGTACCCACTTAGTCATGTAAGTGCATATACACATACACACACATGAGTGTAGACATGTGTTTATTAATTGACAATGACCCAAATCTCTTCCACAAGACTTAAAACCAAATTCAGGGACAAATGGATAGAG
AAGAAAAGGGTCAAACATCGAGATTACATGGATGTTAAATTATATGGAGACGCTAAGAAATAATTGATGGAGCCATTGATGCAAACCGAAGTAGATTTAGAACTTATATGAATTTGATTTATATTTTGCAAGATCAAAAATTAGATGTTA
AGTATCAGATTTTAAGCTTGTTTTAATGGTCAAAAAATTAGGACAGAAATAATATGGACATTTATTAGTATCTTCCATAATTTTTAAGTCTGACACATTTCTATTTTATTCTAACATAAAAAAACTTCCATTATATATTTACTAAGTATA
TTTAATTCACTTAACTCTGTCTTTATAAGTTCCTATTTTAGATGGAATAAGAGAAACAAATTATATCAAGGTAAAACTGATCAAAAGCATAATTGAAAGTTCTGAAAAAAGAAAAATAATAATATGTAGAAAAATGTAACTTAGAGAGTA
ACACATGAACATTGAAGTTAAAACCCAGAAGCCAGATGCTCACAGTTTTATTTTACTTTAAAATAAACCTGTCTGACTGTAGCTTTGTGAAATATCTTAAAACGCAAAAACCAATTGTGTCCTGAAAATTGTTTCAAGAATTTAATATTT
TTATGAAAATTATTTTATTTAACTTTAAGCAATAACTAGAGATTACAATTAAATTTTAATCAAAATGAAGGCTTAGTTCAAACATAAGGAAACAGTGTTTGATTAAAAAAAACACATCTAGTAAGACGTAAGGGGAAAATCACATCCTCT
TTGGAGATGATTATATTTTGATCTGAAGGGTTTGGGGTGTTCATTAGACACTTAATAAAACTTAACTTCCAATGAAAAAGAAATCTTTTGTAAATCATTCTACTTTTGCACTTTGAAAGAAAGGCGTTAATCATAAAGAAGCAAGAATGG
TCAAAATCGAATGCTGCATTTTTATAAACAAAATTACAGACTGTCTGAAATTGAAGAAGAATGAACTAATAATAGCATTCATAACCAAACACAATGATGATTATTGCAGAACATTGTATCACATTTTAGTCCAGAGATAGAATAAAGTTG
AATAACCTTGACTTACACAAAACTGTTTTGGTAGTTGGATTTCATTATCTTAGTGAATTTAGTCATTTTACAATATGTTTGTATTTGGCCATTTACTGTAATCACATTTTTATATCTGTACAATGACACTTTTTGCAGTTGTGGGGTAGT
GTGTAACACTGTCCATCTTGCATCATTGAAACTACTACAATGATACTATCATTTAATAATATTAATATTACTTGAAATAGACTAAGATAAAGAAAAGGGGTCTGTATGATGTGCAGTTTTGTGCCTTTATGTATTTGCCTTGTTCTTTGT
CGAATGTGTGAAATTCCGTACTGTGGTTTTTCCTATAATAGAAAGTAGAGCTGTGTATTAAATTAGACTGTGTCTCTCTGATACCTTTACACTACTGAGAATAGCATGGTTTTGGCCATGTAAACCAATTTTCAAAGTTCTAATGACATA
GCCATGTGTTTTTGGTTTTTTATATTTCATTTTAAAATTTGAGTATCACCATACATTAATTAATACTCCTGTAGTAGATAAGCTGTCATTAAGTAATTCCCAAAAAAAGGGCCATTTGCTTGCATTACTTTGAATTTAATGTTGCGCTTG
TGCACTGTGTTAATATTGTTTGTGATGGATTGGACGTTGTGACTCTTGCCTTTTAAGAAGAAAAAAAAGATAGGACAAAGTATTTGAAGCTCTTAAAATGTACATATTTTGGTTCTTCTATCTCAAATTATTTAAAATGCATAATTCACA
TTTTTGTAATAATTCTATGCAATTTTGTGGCATGATGTTTCTTCCACTTGTAATTTTATGTGCTTTCATCACAAATCCAAAGGAAAGAATAAAAATTTCTTAACACAA

C-Truncated Transcript (5CDS-3UTR) Sequences

Top

Fusion Protein Sequence for KIF16B_PLCB1

In-frame Fusion Protein Sequences.

N-Truncated Protein (5UTR-3CDS) Sequences

>KIF16B_PLCB1_ENST00000378003_ENST00000338037_16553873_8665578 length=534nt
MLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISCSNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRGILVKLMEWEPGREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEG
EARNCCETSIRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGHDSPFAESTFVEDTHENTELVS
SADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQPLIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAA
PVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPLSPTKLSQYPYM

>KIF16B_PLCB1_ENST00000378003_ENST00000378637_16553873_8665578 length=921nt
MRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYP
LESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLS
RIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACL
RIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTE
DLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDV
AEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNH
KTPSSEELGGDIPGKEFDTPL

>KIF16B_PLCB1_ENST00000378003_ENST00000378641_16553873_8665578 length=878nt
MRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYP
LESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLS
RIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACL
RIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTE
DLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDV
AEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKGEGSSSFLSETCHEDPSVSPNFTPPNPQALKW

C-Truncated Protein (5CDS-3UTR) Sequences

Top

Personalized Fusion Protein Sequence for KIF16B_PLCB1

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

Top

Fusion Gene Exprssed Samples for KIF16B_PLCB1

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		BRCA	TCGA-BH-A1FH-01A	KIF16B	chr20	16553873	-	PLCB1	chr20	16553873	+
ChimerDB		BRCA	TCGA-BH-A1FH-01A	KIF16B	chr20	16553873	-	PLCB1	chr20	8665578	+
ChimerDB		BRCA	TCGA-BH-A1FH	KIF16B	chr20	16553873	-	PLCB1	chr20	16553873	+
WashU		BRCA	TCGA-BH-A1FH-01A	KIF16B	chr20	16553874	-	PLCB1	chr20	8665579	+
cBioPortal	BRCA_TCGA_PAN_CAN_ATLAS_2018	BRCA	TCGA-BH-A1FH-01	KIF16B	chr20	16573229		PLCB1	chr20	8684932

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

Top

Related Drugs for KIF16B_PLCB1

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status