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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:DEPDC1B_PDE4D (FusionGDB2 ID:HG55789TG5144)

Fusion Gene Summary for DEPDC1B_PDE4D

Fusion gene summary

Fusion gene information	Fusion gene name: DEPDC1B_PDE4D
	Fusion gene ID: hg55789tg5144
		Hgene	Tgene
	Gene symbol	DEPDC1B	PDE4D
	Gene ID	55789	5144
	Gene name	DEP domain containing 1B	phosphodiesterase 4D
	Synonyms	BRCC3\|XTP1	ACRDYS2\|DPDE3\|HSPDE4D\|PDE43\|PDE4DN2\|STRK1
	Cytomap	5q12.1	5q11.2-q12.1
	Type of gene	protein-coding	protein-coding
	Description	DEP domain-containing protein 1BHBV X-transactivated gene 8 proteinHBV XAg-transactivated protein 8HBxAg transactivated protein 1breast cancer cell 3	3',5'-cyclic-AMP phosphodiesterase 4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DcAMP-specific phosphodiesterase PDE4D6phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)testicular tissue protein Li 136
	Modification date	20240403	20240416
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000265036, ENST00000453022, ENST00000545085, ENST00000509006,	ENST00000545085, ENST00000509006, ENST00000265036, ENST00000453022,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 10 X 9 X 9=810	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 7 X 55 X 16=6160
	# samples	25	54
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(25/81010)=-1.6959938131099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(54/616010)=-3.51189903853143 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DEPDC1B [Title/Abstract] AND PDE4D [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DEPDC1B(59938638)-PDE4D(59481514), # samples:2

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Fusion Gene Breakpoints for DEPDC1B_PDE4D

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
DEPDC1B	chr5	59938638	PDE4D	chr5	59481514
DEPDC1B	chr5	59982788	PDE4D	chr5	59481514
DEPDC1B	chr5	59982788	PDE4D	chr5	59284544
DEPDC1B	chr5	59982789	PDE4D	chr5	58511794

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for DEPDC1B_PDE4D

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
DEPDC1B-PDE4D	Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions M1		DEPDC1B promoter drives phosphodiesterase 4D expression, accelerating cyclic AMP degradation to permanently suppress cytostatic PKA signals.		PDE4 selective inhibitors (roflumilast); PKA activators		Colorectal, lung, and prostate carcinomas

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
DEPDC1B-PDE4D	Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions M1		DEPDC1B promoter drives phosphodiesterase 4D expression, accelerating cyclic AMP degradation to permanently suppress cytostatic PKA signals.	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 38319157; Title: GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines.; PMID: 39956959; Title: 5-hydroxymethylcytosine features of portal venous blood predict metachronous liver metastases of colorectal cancer and reveal phosphodiesterase 4 as a therapeutic target.	PDE4 selective inhibitors (roflumilast); PKA activators	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 39956959; Title: 5-hydroxymethylcytosine features of portal venous blood predict metachronous liver metastases of colorectal cancer and reveal phosphodiesterase 4 as a therapeutic target.	Colorectal, lung, and prostate carcinomas	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 39956959; Title: 5-hydroxymethylcytosine features of portal venous blood predict metachronous liver metastases of colorectal cancer and reveal phosphodiesterase 4 as a therapeutic target.; PMID: 38319157; Title: GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PDE4D	GO:0106072	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	20819076

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Fusion Genomic Features for DEPDC1B_PDE4D

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
DEPDC1B	chr5	59938638	-	PDE4D	chr5	59481514	-	3.88e-02	9.61e-01
DEPDC1B	chr5	59982788	-	PDE4D	chr5	59284544	-	2.02e-06	1.00e+00
DEPDC1B	chr5	59982788	-	PDE4D	chr5	59481514	-	3.14e-04	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for DEPDC1B_PDE4D

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000265036	ENST00000502484	DEPDC1B	chr5	59938638	-	PDE4D	chr5	59481514	-
5CDS-5UTR	ENST00000265036	ENST00000502484	DEPDC1B	chr5	59982788	-	PDE4D	chr5	59481514	-
5CDS-5UTR	ENST00000453022	ENST00000502484	DEPDC1B	chr5	59938638	-	PDE4D	chr5	59481514	-
5CDS-5UTR	ENST00000453022	ENST00000502484	DEPDC1B	chr5	59982788	-	PDE4D	chr5	59481514	-
5CDS-5UTR	ENST00000545085	ENST00000502484	DEPDC1B	chr5	59938638	-	PDE4D	chr5	59481514	-
5CDS-5UTR	ENST00000545085	ENST00000502484	DEPDC1B	chr5	59982788	-	PDE4D	chr5	59481514	-

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000265036	ENST00000340635	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	382	367
ENST00000265036	ENST00000360047	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	382	762
ENST00000265036	ENST00000502484	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	382	762
ENST00000265036	ENST00000502575	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	382	763
ENST00000265036	ENST00000507116	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	382	762
ENST00000265036	ENST00000546160	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	382	762
ENST00000453022	ENST00000340635	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	355	236
ENST00000453022	ENST00000360047	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	355	762
ENST00000453022	ENST00000502484	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	355	762
ENST00000453022	ENST00000502575	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	355	763
ENST00000453022	ENST00000507116	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	355	762
ENST00000453022	ENST00000546160	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	355	762

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000265036	ENST00000340635	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	7.64e-05	1.00e+00
ENST00000265036	ENST00000360047	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	3.28e-05	1.00e+00
ENST00000265036	ENST00000502484	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	1.91e-05	1.00e+00
ENST00000265036	ENST00000502575	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	4.90e-04	1.00e+00
ENST00000265036	ENST00000507116	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	3.28e-05	1.00e+00
ENST00000265036	ENST00000546160	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	1.89e-05	1.00e+00
ENST00000453022	ENST00000340635	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	7.68e-05	1.00e+00
ENST00000453022	ENST00000360047	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	3.29e-05	1.00e+00
ENST00000453022	ENST00000502484	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	2.02e-05	1.00e+00
ENST00000453022	ENST00000502575	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	5.33e-04	9.99e-01
ENST00000453022	ENST00000507116	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	3.29e-05	1.00e+00
ENST00000453022	ENST00000546160	DEPDC1B	chr5	59982788	PDE4D	chr5	58511794	2.00e-05	1.00e+00

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for DEPDC1B_PDE4D

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PDE4D

chr5:59982788

chr5:58511794

ENST00000340635

Q08499

762_773

151.66666666666666

810.0

Compositional bias

Polar residues

Tgene

PDE4D

chr5:59982788

chr5:58511794

ENST00000340635

Q08499

779_796

151.66666666666666

810.0

Compositional bias

Acidic residues

Tgene

PDE4D

chr5:59982788

chr5:58511794

ENST00000340635

Q08499

386_715

151.66666666666666

810.0

Domain

PDEase

Tgene

PDE4D

chr5:59982788

chr5:58511794

ENST00000340635

Q08499

343_364

151.66666666666666

810.0

Region

Disordered

Tgene

PDE4D

chr5:59982788

chr5:58511794

ENST00000340635

Q08499

710_729

151.66666666666666

810.0

Region

Disordered

Tgene

PDE4D

chr5:59982788

chr5:58511794

ENST00000340635

Q08499

739_809

151.66666666666666

810.0

Region

Disordered

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PDE4D

chr5:59982788

chr5:58511794

ENST00000340635

Q08499

58_89

151.66666666666666

810.0

Compositional bias

Pro residues

Tgene

PDE4D

chr5:59982788

chr5:58511794

ENST00000340635

Q08499

90_102

151.66666666666666

810.0

Compositional bias

Low complexity

Tgene

PDE4D

chr5:59982788

chr5:58511794

ENST00000340635

Q08499

1_107

151.66666666666666

810.0

Region

Disordered

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for DEPDC1B_PDE4D

In-frame Fusion Transcript Sequences.

>DEPDC1B_PDE4D_ENST00000265036_ENST00000340635_59982788_58511794 length=7983nt 
 Breakpoint=382nt
AAACTGCTGCTCCTCCGGCTGGCGGGGATCAGCGCTGGCGCGGCTGCGGCCGCTGCTGCCTACGCGCCATGGAGCATCGCATCGTGGGGCCCGGGCCGTACCGAGCTACCAGGCTGTGGAATGAGACCGTGGAGCTTTTTCGTGCTAAGA
TGCCGTTACGGAAACATCGCTGTCGTTTCAAGAGCTATGAGCATTGTTTCACAGCGGCCGAAGCTGTGGATTGGCTGCATGAGCTGCTGAGGTGCAGTCAAAACTTCGGCCCTGAAGTGACCCGCAAACAAACGGTCCAGCTGCTAAAAA
AATTCCTGAAGAATCACGTTATTGAAGACATCAAGGGAAAATGGGGTGAGGAAGATTTTGAAGACAATCGTCACTTATACAGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCG
GGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTC
CATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGA
AACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGTTTAAAAGGATGCTTAATCGGGAGCTCACCCATCTCTCTGAAATGAGTCGGT
CTGGAAATCAAGTGTCAGAGTTTATATCAAACACATTCTTAGATAAGCAACATGAAGTGGAAATTCCTTCTCCAACTCAGAAGGAAAAGGAGAAAAAGAAAAGACCAATGTCTCAGATCAGTGGAGTCAAGAAATTGATGCACAGCTCTA
GTCTGACTAATTCAAGTATCCCAAGGTTTGGAGTTAAAACTGAACAAGAAGATGTCCTTGCCAAGGAACTAGAAGATGTGAACAAATGGGGTCTTCATGTTTTCAGAATAGCAGAGTTGTCTGGTAACCGGCCCTTGACTGTTATCATGC
ACACCATTTTTCAGGAACGGGATTTATTAAAAACATTTAAAATTCCAGTAGATACTTTAATTACATATCTTATGACTCTCGAAGACCATTACCATGCTGATGTGGCCTATCACAACAATATCCATGCTGCAGATGTTGTCCAGTCTACTC
ATGTGCTATTATCTACACCTGCTTTGGAGGCTGTGTTTACAGATTTGGAGATTCTTGCAGCAATTTTTGCCAGTGCAATACATGATGTAGATCATCCTGGTGTGTCCAATCAATTTCTGATCAATACAAACTCTGAACTTGCCTTGATGT
ACAATGATTCCTCAGTCTTAGAGAACCATCATTTGGCTGTGGGCTTTAAATTGCTTCAGGAAGAAAACTGTGACATTTTCCAGAATTTGACCAAAAAACAAAGACAATCTTTAAGGAAAATGGTCATTGACATCGTACTTGCAACAGATA
TGTCAAAACACATGAATCTACTGGCTGATTTGAAGACTATGGTTGAAACTAAGAAAGTGACAAGCTCTGGAGTTCTTCTTCTTGATAATTATTCCGATAGGATTCAGGTTCTTCAGAATATGGTGCACTGTGCAGATCTGAGCAACCCAA
CAAAGCCTCTCCAGCTGTACCGCCAGTGGACGGACCGGATAATGGAGGAGTTCTTCCGCCAAGGAGACCGAGAGAGGGAACGTGGCATGGAGATAAGCCCCATGTGTGACAAGCACAATGCTTCCGTGGAAAAATCACAGGTGGGCTTCA
TAGACTATATTGTTCATCCCCTCTGGGAGACATGGGCAGACCTCGTCCACCCTGACGCCCAGGATATTTTGGACACTTTGGAGGACAATCGTGAATGGTACCAGAGCACAATCCCTCAGAGCCCCTCTCCTGCACCTGATGACCCAGAGG
AGGGCCGGCAGGGTCAAACTGAGAAATTCCAGTTTGAACTAACTTTAGAGGAAGATGGTGAGTCAGACACGGAAAAGGACAGTGGCAGTCAAGTGGAAGAAGACACTAGCTGCAGTGACTCCAAGACTCTTTGTACTCAAGACTCAGAGT
CTACTGAAATTCCCCTTGATGAACAGGTTGAAGAGGAGGCAGTAGGGGAAGAAGAGGAAAGCCAGCCTGAAGCCTGTGTCATAGATGATCGTTCTCCTGACACGTAACAGTGCAAAAACTTTCATGCCTTTTTTTTTTTTAAGTAGAAAA
ATTGTTTCCAAAGTGCATGTCACATGCCACAACCACGGTCACACCTCACTGTCATCTGCCAGGACGTTTGTTGAACAAAACTGACCTTGACTACTCAGTCCAGCGCTCAGGAATATCGTAACCAGTTTTTTCACCTCCATGTCATCCGAG
CAAGGTGGACATCTTCACGAACAGCGTTTTTAACAAGATTTCAGCTTGGTAGAGCTGACAAAGCAGATAAAATCTACTCCAAATTATTTTCAAGAGAGTGTGACTCATCAGGCAGCCCAAAAGTTTATTGGACTTGGGGTTTCTATTCCT
TTTTATTTGTTTGCAATATTTTCAGAAGAAAGGCATTGCACAGAGTGAACTTAATGGACGAAGCAACAAATATGTCAAGAACAGGACATAGCACGAATCTGTTACCAGTAGGAGGAGGATGAGCCACAGAAATTGCATAATTTTCTAATT
TCAAGTCTTCCTGATACATGACTGAATAGTGTGGTTCAGTGAGCTGCACTGACCTCTACATTTTGTATGATATGTAAAACAGATTTTTTGTAGAGCTTACTTTTATTATTAAATGTATTGAGGTATTATATTTAAAAAAAACTATGTTCA
GAACTTCATCTGCCACTGGTTATTTTTTTCTAAGGAGTAACTTGCAAGTTTTCAGTACAAATCTGTGCTACACTGGATAAAAATCTAATTTATGAATTTTACTTGCACCTTATAGTTCATAGCAATTAACTGATTTGTAGTGATTCATTG
TTTGTTTTATATACCAATGACTTCCATATTTTAAAAGAGAAAAACAACTTTATGTTGCAGGAAACCCTTTTTGTAAGTCTTTATTATTTACTTTGCATTTTGTTTCACTCTTTCCAGATAAGCAGAGTTGCTCTTCACCAGTGTTTTTCT
TCATGTGCAAAGTGACTATTTGTTCTATAATACTTTTATGTGTGTTATATCAAATGTGTCTTAAGCTTCATGCAAACTCAGTCATCAGTTCGTGTTGTCTGAAGCAAGTGGGAGATATATAAATACCCAGTAGCTAAAATGGTCAGTCTT
TTTTAGATGTTTTCCTACTTAGTATCTCCTAATAACGTTTTGCTGTGTCACTAGATGTTCATTTCACAAGTGCATGTCTTTCTAATAATCCACACATTTCATGCTCTAATAATCCACACATTTCATGCTCATTTTTATTGTTTTTACAGC
CAGTTATAGTAAGAAAAAGGTTTTTCCCCTTGTGCTGCTTTATAATTTAGCGTGTGTCTGAACCTTATCCATGTTTGCTAGATGAGGTCTTGTCAAATATATCACTACCATTGTCACCGGTGAAAAGAAACAGGTAGTTAAGTTAGGGTT
AACATTCATTTCAACCACGAGGTTGTATATCATGACTAGCTTTTACTCTTGGTTTACAGAGAAAAGTTAAACAGCCAACTAGGCAGTTTTTAAGAATATTAACAATATATTAACAAACACCAATACAACTAATCCTATTTGGTTTTAATG
ATTTCACCATGGGATTAAGAACTATATCAGGAACATCCCTGAGAAACGGTTTTAAGTGTAGCAACTACTCTTCCTTAATGGACAGCCACATAACGTGTAGGAAGTCCTTTATCACTTATCCTCGATCCATAAGCATATCTTGCAGAGGGG
AACTACTTCTTTAAACACATGGAGGGAAAGAAGATGATGCCACTGGCACCAGAGGGTTAGTACTGTGATGCATCCTAAAATATTTATTATATTGGTAAAAATTCTGGTTAAATAAAAAATTAGAGATCACTCTTGGCTGATTTCAGCACC
AGGAACTGTATTACAGTTTTAGAGATTAATTCCTAGTGTTTACCTGATTATAGCAGTTGGCATCATGGGGCATTTAATTCTGACTTTATCCCCACGTCAGCCTTAATAAAGTCTTCTTTACCTTCTCTATGAAGACTTTAAAGCCCAAAT
AATCATTTTTCACATTGATATTCAAGAATTGAGATAGATAGAAGCCAAAGTGGGTATCTGACAAGTGGAAAATCAAACGTTTAAGAAGAATTACAACTCTGAAAAGCATTTATATGTGGAACTTCTCAAGGAGCCTCCTGGGGACTGGAA
AGTAAGTCATCAGCCAGGCAAATGACTCATGCTGAAGAGAGTCCCCATTTCAGTCCCCTGAGATCTAGCTGATGCTTAGATCCTTTGAAATAAAAATTATGTCTTTATAACTCTGATCTTTTACATAAAGCAGAAGAGGAATCAACTAGT
TAATTGCAAGGTTTCTACTCTGTTTCCTCTGTAAAGATCAGATGGTAATCTTTCAAATAAGAAAAAAATAAAGACGTATGTTTGACCAAGTAGTTTCACAAGAATATTTGGGAACTTGTTTCTTTTAATTTTATTTGTCCCTGAGTGAAG
TCTAGAAAGAAAGGTAAAGAGTCTAGAGTTTATTCCTCTTTCCAAAACATTCTCATTCCTCTCCTCCCTACACTTAGTATTTCCCCCACAGAGTGCCTAGAATCTTAATAATGAATAAAATAAAAAGCAGCAATATGTCATTAACAAATC
CAGACCTGAAAGGGTAAAGGGTTTATAACTGCACTAATAAAGAGAGGCTCTTTTTTTTTCTTCCAGTTTGTTGGTTTTTAATGGTACCGTGTTGTAAAGATACCCACTAATGGACAATCAAATTGCAGAAAAGGCTCAATATCCAAGAGA
CAGGGACTAATGCACTGTACAATCTGCTTATCCTTGCCCTTCTCTCTTGCCAAAGTGTGCTTCAGAAATATATACTGCTTTAAAAAAGAATAAAAGAATATCCTTTTACAAGTGGCTTTACATTTCCTAAAATGCCATAAGAAAATGCAA
TATCTGGGTACTGTATGGGGAAAAAAATGTCCAAGTTTGTGTAAAACCAGTGCATTTCAGCTTGCAAGTTACTGAACACAATAATGCTGTTTTAATTTTGTTTTATATCAGTTAAAATTCACAATAATGTAGATAGAACAAATTACAGAC
AAGGAAAGAAAAAACTTGAATGAAATGGATTTTACAGAAAGCTTTATGATAATTTTTGAATGCATTATTTATTTTTTGTGCCATGCATTTTTTTTCTCACCAAATGACCTTACCTGTAATACAGTCTTGTTTGTCTGTTTACAACCATGT
ATTTATTGCAATGTACATACTGTAATGTTAATTGTAAATTATCTGTTCTTATTAAAACATCATCCCATGATGGGATGGTGTTGATATATTTGGAAACTCTTGGTGAGAGAATGAATGGTGTGTATACATACTCTGTACATTTTTCTTTTC
TCCTGTAATATAGTCTTGTCACCTTAGAGCTTGTTTATGGAAGATTCAAGAAAACTATAAAATACTTAAAGATATATAAATTTAAAAAAACATAGCTGCAGGTCTTTGGTCCCAGGGCTGTGCCTTAACTTTAACCAATATTTTCTTCTG
TTTTGCTGCATTTGAAAGGTAACAGTGGAGCTAGGGCTGGGCATTTTACATCCAGGCTTTTAATTGATTAGAATTCTGCCAATAGGTGGATTTTACAAAACCACAGACAACCTCTGAAAGATTCTGAGACCCTTTTGAGACAGAAGCTCT
TAAGTACTTCTTGCCAGGGAGCAGCACTGCATGTGTGATGGTTGTTTGCCATCTGTTGATCAGGAACTACTTCAGCTACTTGCATTTGATTATTTCCTTTTTTTTTTTTTTTAACTCGGAAACACAACTGGGGAAATATATTCTTTCCCA
GTGATTATAAACAATCTTTTTCTTTTTTTTAAGTCCTTTTGGCTTCTAGAGCTCATAGGAAAATGGACTTGATTTGAAATTGGAGCCAGAGTTTACTCGTGTTGGTTATCTATTCATCAGCTTCCTGACATGTTAAGAGAATACATTAAA
GAGAAAATACTGTTTTTTAATCCTAAAATTTTTCTTCCACTAAGATAAACCAAATGTCCTTACATATATGTAAACCCATCTATTTAAACGCAAAGGTGGGTTGATGTCAGTTTACATAGCAGAAAGCATTCACTATCCTCTAAGATTTGT
TTCTGCAAAACTTTCATTGCTTTAGAATTTTAAAATTTCACCTTGTACAATGGCCAGCCCCTAAAGCAGGAAACATTTATAATGGATTATATGGAAACATCCTCCCAGTACTTGCCCAGCCCTTGAATCATGTGGCTTTTCAGTGAAAGG
AAAGATTCTTTTTCTAGGAAAAATGAGCCTATTTTATTTTATTTTATTTTATTTTTTGACACAAACTGTAGATTTTAGCAGCCCTGGCCCAAAGGAATTTGATTACTTTTGTTTTAAACAGTACAAAGGGGACACTATAATTACAAAAAC
ATCCTTAACTGATTTGAGTTGTTTTTATTTCTTTGGATATATTTTCAGAGTGGTAAATTGTGTGTGAGAATTACAAATGATTATTCTTTTAGTGGTTTCTTAGCCTCTCTTACAGCCCACGGGGATAGTACTGTACATCAATACCTTCAT
ATGAAATTTTTATATGCAATGAAAATAAAAGCATGGGTTGATTCTGCCTATTTATGACTCAATCTTTTACAAATAAAAGATTATTCATTTTAAATTATAGTTCAATCAGCATGTCTCTTAGGATACTGAACGTGGTTGAAATGAAAGGAT
AGTGACATCATAAGTTAGTACTGATATTCATAACCAAATAAAGCCAACTTGAGTAATTTTGCTACATTAAAAATTACCAAAATTACTTAGATGGCCTATAAGATTAAGCATGGTGTTTTCTAAGCAAGCTTTGAAAGGGGCCTTCCATAC
TTACTTAATTGAATATTCTGGGATATTGAAAATTATTCAGATACTTGACAATTATTTTTGGTTACCTACTCCGCAAACTACAAAGTTTTAAGGACTCAACAATAAGTTAATGAGACACAGTGTTTGCTTTCATGGAGCTTACAGTCTGGA
GGGGACAAAGGCTTAAACAATACTCATATAATTATATATGTGATCAGTACAATGAAGGAGCTCAGTGGGGTAAATAAGCAGGAACCTGAACTTGATCTGTTCCGGAGGGCCACAGAAGGCTTCCTTGAGGCCTTGAGAAAGTGATTTGCA
TCTGAGTTCTGAAGGATTGTAAGAGGTAACTAGGGAAAAAGTTGACAGGAAGAGGAAGGGGATCCAGACAAGAAACATTTGCAAAGATCTTGAGGCATAAATGAGCTTGAGACATCTGGAGAAACTGAGGAAAAGTGAGAGAGTAGGCAG
GGCCTGGAGCCGCAGAGCCATTGCTAACCATCCTGTGTGAGATATCCCCCATTCTGTAGCTTTATTCTCATAACCCTGCTCAATTTTCTTTATAACACTTCTCACAGATTTATATACGTGTTTGTTTTTGTTATCTGTCTCTCCCACCAG
ACCACAGCTCCATGAGAGCAAGGTCTTTGCTTACCAATATATCACTAGCACTTAAAACTATGCCTGGTACACAGTAGGTTCTTAATATGTGTTGAATATAGCCATCAAATTGATATTGGATATAATTCAATCTGATAAGATATTTTGAGA
TATTAAAGAGTTTTTAACTTGATACCATAAAAA

>DEPDC1B_PDE4D_ENST00000265036_ENST00000360047_59982788_58511794 length=3333nt 
 Breakpoint=382nt
AAACTGCTGCTCCTCCGGCTGGCGGGGATCAGCGCTGGCGCGGCTGCGGCCGCTGCTGCCTACGCGCCATGGAGCATCGCATCGTGGGGCCCGGGCCGTACCGAGCTACCAGGCTGTGGAATGAGACCGTGGAGCTTTTTCGTGCTAAGA
TGCCGTTACGGAAACATCGCTGTCGTTTCAAGAGCTATGAGCATTGTTTCACAGCGGCCGAAGCTGTGGATTGGCTGCATGAGCTGCTGAGGTGCAGTCAAAACTTCGGCCCTGAAGTGACCCGCAAACAAACGGTCCAGCTGCTAAAAA
AATTCCTGAAGAATCACGTTATTGAAGACATCAAGGGAAAATGGGGTGAGGAAGATTTTGAAGACAATCGTCACTTATACAGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCG
GGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTC
CATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGA
AACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGTTTAAAAGGATGCTTAATCGGGAGCTCACCCATCTCTCTGAAATGAGTCGGT
CTGGAAATCAAGTGTCAGAGTTTATATCAAACACATTCTTAGATAAGCAACATGAAGTGGAAATTCCTTCTCCAACTCAGAAGGAAAAGGAGAAAAAGAAAAGACCAATGTCTCAGATCAGTGGAGTCAAGAAATTGATGCACAGCTCTA
GTCTGACTAATTCAAGTATCCCAAGGTTTGGAGTTAAAACTGAACAAGAAGATGTCCTTGCCAAGGAACTAGAAGATGTGAACAAATGGGGTCTTCATGTTTTCAGAATAGCAGAGTTGTCTGGTAACCGGCCCTTGACTGTTATCATGC
ACACCATTTTTCAGGAACGGGATTTATTAAAAACATTTAAAATTCCAGTAGATACTTTAATTACATATCTTATGACTCTCGAAGACCATTACCATGCTGATGTGGCCTATCACAACAATATCCATGCTGCAGATGTTGTCCAGTCTACTC
ATGTGCTATTATCTACACCTGCTTTGGAGGCTGTGTTTACAGATTTGGAGATTCTTGCAGCAATTTTTGCCAGTGCAATACATGATGTAGATCATCCTGGTGTGTCCAATCAATTTCTGATCAATACAAACTCTGAACTTGCCTTGATGT
ACAATGATTCCTCAGTCTTAGAGAACCATCATTTGGCTGTGGGCTTTAAATTGCTTCAGGAAGAAAACTGTGACATTTTCCAGAATTTGACCAAAAAACAAAGACAATCTTTAAGGAAAATGGTCATTGACATCGTACTTGCAACAGATA
TGTCAAAACACATGAATCTACTGGCTGATTTGAAGACTATGGTTGAAACTAAGAAAGTGACAAGCTCTGGAGTTCTTCTTCTTGATAATTATTCCGATAGGATTCAGGTTCTTCAGAATATGGTGCACTGTGCAGATCTGAGCAACCCAA
CAAAGCCTCTCCAGCTGTACCGCCAGTGGACGGACCGGATAATGGAGGAGTTCTTCCGCCAAGGAGACCGAGAGAGGGAACGTGGCATGGAGATAAGCCCCATGTGTGACAAGCACAATGCTTCCGTGGAAAAATCACAGGTGGGCTTCA
TAGACTATATTGTTCATCCCCTCTGGGAGACATGGGCAGACCTCGTCCACCCTGACGCCCAGGATATTTTGGACACTTTGGAGGACAATCGTGAATGGTACCAGAGCACAATCCCTCAGAGCCCCTCTCCTGCACCTGATGACCCAGAGG
AGGGCCGGCAGGGTCAAACTGAGAAATTCCAGTTTGAACTAACTTTAGAGGAAGATGGTGAGTCAGACACGGAAAAGGACAGTGGCAGTCAAGTGGAAGAAGACACTAGCTGCAGTGACTCCAAGACTCTTTGTACTCAAGACTCAGAGT
CTACTGAAATTCCCCTTGATGAACAGGTTGAAGAGGAGGCAGTAGGGGAAGAAGAGGAAAGCCAGCCTGAAGCCTGTGTCATAGATGATCGTTCTCCTGACACGTAACAGTGCAAAAACTTTCATGCCTTTTTTTTTTTTAAGTAGAAAA
ATTGTTTCCAAAGTGCATGTCACATGCCACAACCACGGTCACACCTCACTGTCATCTGCCAGGACGTTTGTTGAACAAAACTGACCTTGACTACTCAGTCCAGCGCTCAGGAATATCGTAACCAGTTTTTTCACCTCCATGTCATCCGAG
CAAGGTGGACATCTTCACGAACAGCGTTTTTAACAAGATTTCAGCTTGGTAGAGCTGACAAAGCAGATAAAATCTACTCCAAATTATTTTCAAGAGAGTGTGACTCATCAGGCAGCCCAAAAGTTTATTGGACTTGGGGTTTCTATTCCT
TTTTATTTGTTTGCAATATTTTCAGAAGAAAGGCATTGCACAGAGTGAACTTAATGGACGAAGCAACAAATATGTCAAGAACAGGACATAGCACGAATCTGTTACCAGTAGGAGGAGGATGAGCCACAGAAATTGCATAATTTTCTAATT
TCAAGTCTTCCTGATACATGACTGAATAGTGTGGTTCAGTGAGCTGCACTGACCTCTACATTTTGTATGATATGTAAAACAGATTTTTTGTAGAGCTTACTTTTATTATTAAATGTATTGAGGTATTATATTTAAAAAAAACTATGTTCA
GAACTTCATCTGCCACTGGTTATTTTTTTCTAAGGAGTAACTTGCAAGTTTTCAGTACAAATCTGTGCTACACTGGATAAAAATCTAATTTATGAATTTTACTTGCACCTTATAGTTCATAGCAATTAACTGATTTGTAGTGATTCATTG
TTTGTTTTATATACCAATGACTTCCATATTTTAAAAGAGAAAAACAACTTTATGTTGCAGGAAACCCTTTTTGTAAGTCTTTATTATTTACTTTGCATTTTGTTTCACTCTTTCCAGATAAGCAGAGTTGCTCTTCACCAGTGTTTTTCT
TCATGTGCAAAGTGACTATTTGTTCTATAATAC

>DEPDC1B_PDE4D_ENST00000265036_ENST00000502484_59982788_58511794 length=2364nt 
 Breakpoint=382nt
AAACTGCTGCTCCTCCGGCTGGCGGGGATCAGCGCTGGCGCGGCTGCGGCCGCTGCTGCCTACGCGCCATGGAGCATCGCATCGTGGGGCCCGGGCCGTACCGAGCTACCAGGCTGTGGAATGAGACCGTGGAGCTTTTTCGTGCTAAGA
TGCCGTTACGGAAACATCGCTGTCGTTTCAAGAGCTATGAGCATTGTTTCACAGCGGCCGAAGCTGTGGATTGGCTGCATGAGCTGCTGAGGTGCAGTCAAAACTTCGGCCCTGAAGTGACCCGCAAACAAACGGTCCAGCTGCTAAAAA
AATTCCTGAAGAATCACGTTATTGAAGACATCAAGGGAAAATGGGGTGAGGAAGATTTTGAAGACAATCGTCACTTATACAGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCG
GGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTC
CATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGA
AACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGTTTAAAAGGATGCTTAATCGGGAGCTCACCCATCTCTCTGAAATGAGTCGGT
CTGGAAATCAAGTGTCAGAGTTTATATCAAACACATTCTTAGATAAGCAACATGAAGTGGAAATTCCTTCTCCAACTCAGAAGGAAAAGGAGAAAAAGAAAAGACCAATGTCTCAGATCAGTGGAGTCAAGAAATTGATGCACAGCTCTA
GTCTGACTAATTCAAGTATCCCAAGGTTTGGAGTTAAAACTGAACAAGAAGATGTCCTTGCCAAGGAACTAGAAGATGTGAACAAATGGGGTCTTCATGTTTTCAGAATAGCAGAGTTGTCTGGTAACCGGCCCTTGACTGTTATCATGC
ACACCATTTTTCAGGAACGGGATTTATTAAAAACATTTAAAATTCCAGTAGATACTTTAATTACATATCTTATGACTCTCGAAGACCATTACCATGCTGATGTGGCCTATCACAACAATATCCATGCTGCAGATGTTGTCCAGTCTACTC
ATGTGCTATTATCTACACCTGCTTTGGAGGCTGTGTTTACAGATTTGGAGATTCTTGCAGCAATTTTTGCCAGTGCAATACATGATGTAGATCATCCTGGTGTGTCCAATCAATTTCTGATCAATACAAACTCTGAACTTGCCTTGATGT
ACAATGATTCCTCAGTCTTAGAGAACCATCATTTGGCTGTGGGCTTTAAATTGCTTCAGGAAGAAAACTGTGACATTTTCCAGAATTTGACCAAAAAACAAAGACAATCTTTAAGGAAAATGGTCATTGACATCGTACTTGCAACAGATA
TGTCAAAACACATGAATCTACTGGCTGATTTGAAGACTATGGTTGAAACTAAGAAAGTGACAAGCTCTGGAGTTCTTCTTCTTGATAATTATTCCGATAGGATTCAGGTTCTTCAGAATATGGTGCACTGTGCAGATCTGAGCAACCCAA
CAAAGCCTCTCCAGCTGTACCGCCAGTGGACGGACCGGATAATGGAGGAGTTCTTCCGCCAAGGAGACCGAGAGAGGGAACGTGGCATGGAGATAAGCCCCATGTGTGACAAGCACAATGCTTCCGTGGAAAAATCACAGGTGGGCTTCA
TAGACTATATTGTTCATCCCCTCTGGGAGACATGGGCAGACCTCGTCCACCCTGACGCCCAGGATATTTTGGACACTTTGGAGGACAATCGTGAATGGTACCAGAGCACAATCCCTCAGAGCCCCTCTCCTGCACCTGATGACCCAGAGG
AGGGCCGGCAGGGTCAAACTGAGAAATTCCAGTTTGAACTAACTTTAGAGGAAGATGGTGAGTCAGACACGGAAAAGGACAGTGGCAGTCAAGTGGAAGAAGACACTAGCTGCAGTGACTCCAAGACTCTTTGTACTCAAGACTCAGAGT
CTACTGAAATTCCCCTTGATGAACAGGTTGAAGAGGAGGCAGTAGGGGAAGAAGAGGAAAGCCAGCCTGAAGCCTGTGTCATAGATGATCGTTCTCCTGACACGTAACAGTGCA

>DEPDC1B_PDE4D_ENST00000265036_ENST00000502575_59982788_58511794 length=1032nt 
 Breakpoint=382nt
AAACTGCTGCTCCTCCGGCTGGCGGGGATCAGCGCTGGCGCGGCTGCGGCCGCTGCTGCCTACGCGCCATGGAGCATCGCATCGTGGGGCCCGGGCCGTACCGAGCTACCAGGCTGTGGAATGAGACCGTGGAGCTTTTTCGTGCTAAGA
TGCCGTTACGGAAACATCGCTGTCGTTTCAAGAGCTATGAGCATTGTTTCACAGCGGCCGAAGCTGTGGATTGGCTGCATGAGCTGCTGAGGTGCAGTCAAAACTTCGGCCCTGAAGTGACCCGCAAACAAACGGTCCAGCTGCTAAAAA
AATTCCTGAAGAATCACGTTATTGAAGACATCAAGGGAAAATGGGGTGAGGAAGATTTTGAAGACAATCGTCACTTATACAGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCG
GGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTC
CATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGGATCCTGGATGGAAT
TGAACCCATATACGTTACTTGACATGTGAAACACGTGTGACCCTGGCAGATGATTTGGCTGACCTTGAAAACTACAGCTGTTTAGTCACTTTGAAAACAATGCAATACAAGTGATTTACTAGGCTTCAGTTTTAACCATTTTATGCTGAC
TGGTGGAAATTCTAACCCTTCAGAAAGAAAAAAAAATTGTGAAGCAATGGAAATGTACCATCCTGGGTATTAATGTCATTAATTTTCAATACATTTTCTCACAAAAAGTATAAAGAAGTCTTTGCTTGACCT

>DEPDC1B_PDE4D_ENST00000265036_ENST00000507116_59982788_58511794 length=3333nt 
 Breakpoint=382nt
AAACTGCTGCTCCTCCGGCTGGCGGGGATCAGCGCTGGCGCGGCTGCGGCCGCTGCTGCCTACGCGCCATGGAGCATCGCATCGTGGGGCCCGGGCCGTACCGAGCTACCAGGCTGTGGAATGAGACCGTGGAGCTTTTTCGTGCTAAGA
TGCCGTTACGGAAACATCGCTGTCGTTTCAAGAGCTATGAGCATTGTTTCACAGCGGCCGAAGCTGTGGATTGGCTGCATGAGCTGCTGAGGTGCAGTCAAAACTTCGGCCCTGAAGTGACCCGCAAACAAACGGTCCAGCTGCTAAAAA
AATTCCTGAAGAATCACGTTATTGAAGACATCAAGGGAAAATGGGGTGAGGAAGATTTTGAAGACAATCGTCACTTATACAGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCG
GGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTC
CATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGA
AACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGTTTAAAAGGATGCTTAATCGGGAGCTCACCCATCTCTCTGAAATGAGTCGGT
CTGGAAATCAAGTGTCAGAGTTTATATCAAACACATTCTTAGATAAGCAACATGAAGTGGAAATTCCTTCTCCAACTCAGAAGGAAAAGGAGAAAAAGAAAAGACCAATGTCTCAGATCAGTGGAGTCAAGAAATTGATGCACAGCTCTA
GTCTGACTAATTCAAGTATCCCAAGGTTTGGAGTTAAAACTGAACAAGAAGATGTCCTTGCCAAGGAACTAGAAGATGTGAACAAATGGGGTCTTCATGTTTTCAGAATAGCAGAGTTGTCTGGTAACCGGCCCTTGACTGTTATCATGC
ACACCATTTTTCAGGAACGGGATTTATTAAAAACATTTAAAATTCCAGTAGATACTTTAATTACATATCTTATGACTCTCGAAGACCATTACCATGCTGATGTGGCCTATCACAACAATATCCATGCTGCAGATGTTGTCCAGTCTACTC
ATGTGCTATTATCTACACCTGCTTTGGAGGCTGTGTTTACAGATTTGGAGATTCTTGCAGCAATTTTTGCCAGTGCAATACATGATGTAGATCATCCTGGTGTGTCCAATCAATTTCTGATCAATACAAACTCTGAACTTGCCTTGATGT
ACAATGATTCCTCAGTCTTAGAGAACCATCATTTGGCTGTGGGCTTTAAATTGCTTCAGGAAGAAAACTGTGACATTTTCCAGAATTTGACCAAAAAACAAAGACAATCTTTAAGGAAAATGGTCATTGACATCGTACTTGCAACAGATA
TGTCAAAACACATGAATCTACTGGCTGATTTGAAGACTATGGTTGAAACTAAGAAAGTGACAAGCTCTGGAGTTCTTCTTCTTGATAATTATTCCGATAGGATTCAGGTTCTTCAGAATATGGTGCACTGTGCAGATCTGAGCAACCCAA
CAAAGCCTCTCCAGCTGTACCGCCAGTGGACGGACCGGATAATGGAGGAGTTCTTCCGCCAAGGAGACCGAGAGAGGGAACGTGGCATGGAGATAAGCCCCATGTGTGACAAGCACAATGCTTCCGTGGAAAAATCACAGGTGGGCTTCA
TAGACTATATTGTTCATCCCCTCTGGGAGACATGGGCAGACCTCGTCCACCCTGACGCCCAGGATATTTTGGACACTTTGGAGGACAATCGTGAATGGTACCAGAGCACAATCCCTCAGAGCCCCTCTCCTGCACCTGATGACCCAGAGG
AGGGCCGGCAGGGTCAAACTGAGAAATTCCAGTTTGAACTAACTTTAGAGGAAGATGGTGAGTCAGACACGGAAAAGGACAGTGGCAGTCAAGTGGAAGAAGACACTAGCTGCAGTGACTCCAAGACTCTTTGTACTCAAGACTCAGAGT
CTACTGAAATTCCCCTTGATGAACAGGTTGAAGAGGAGGCAGTAGGGGAAGAAGAGGAAAGCCAGCCTGAAGCCTGTGTCATAGATGATCGTTCTCCTGACACGTAACAGTGCAAAAACTTTCATGCCTTTTTTTTTTTTAAGTAGAAAA
ATTGTTTCCAAAGTGCATGTCACATGCCACAACCACGGTCACACCTCACTGTCATCTGCCAGGACGTTTGTTGAACAAAACTGACCTTGACTACTCAGTCCAGCGCTCAGGAATATCGTAACCAGTTTTTTCACCTCCATGTCATCCGAG
CAAGGTGGACATCTTCACGAACAGCGTTTTTAACAAGATTTCAGCTTGGTAGAGCTGACAAAGCAGATAAAATCTACTCCAAATTATTTTCAAGAGAGTGTGACTCATCAGGCAGCCCAAAAGTTTATTGGACTTGGGGTTTCTATTCCT
TTTTATTTGTTTGCAATATTTTCAGAAGAAAGGCATTGCACAGAGTGAACTTAATGGACGAAGCAACAAATATGTCAAGAACAGGACATAGCACGAATCTGTTACCAGTAGGAGGAGGATGAGCCACAGAAATTGCATAATTTTCTAATT
TCAAGTCTTCCTGATACATGACTGAATAGTGTGGTTCAGTGAGCTGCACTGACCTCTACATTTTGTATGATATGTAAAACAGATTTTTTGTAGAGCTTACTTTTATTATTAAATGTATTGAGGTATTATATTTAAAAAAAACTATGTTCA
GAACTTCATCTGCCACTGGTTATTTTTTTCTAAGGAGTAACTTGCAAGTTTTCAGTACAAATCTGTGCTACACTGGATAAAAATCTAATTTATGAATTTTACTTGCACCTTATAGTTCATAGCAATTAACTGATTTGTAGTGATTCATTG
TTTGTTTTATATACCAATGACTTCCATATTTTAAAAGAGAAAAACAACTTTATGTTGCAGGAAACCCTTTTTGTAAGTCTTTATTATTTACTTTGCATTTTGTTTCACTCTTTCCAGATAAGCAGAGTTGCTCTTCACCAGTGTTTTTCT
TCATGTGCAAAGTGACTATTTGTTCTATAATAC

>DEPDC1B_PDE4D_ENST00000265036_ENST00000546160_59982788_58511794 length=2357nt 
 Breakpoint=382nt
AAACTGCTGCTCCTCCGGCTGGCGGGGATCAGCGCTGGCGCGGCTGCGGCCGCTGCTGCCTACGCGCCATGGAGCATCGCATCGTGGGGCCCGGGCCGTACCGAGCTACCAGGCTGTGGAATGAGACCGTGGAGCTTTTTCGTGCTAAGA
TGCCGTTACGGAAACATCGCTGTCGTTTCAAGAGCTATGAGCATTGTTTCACAGCGGCCGAAGCTGTGGATTGGCTGCATGAGCTGCTGAGGTGCAGTCAAAACTTCGGCCCTGAAGTGACCCGCAAACAAACGGTCCAGCTGCTAAAAA
AATTCCTGAAGAATCACGTTATTGAAGACATCAAGGGAAAATGGGGTGAGGAAGATTTTGAAGACAATCGTCACTTATACAGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCG
GGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTC
CATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGA
AACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGTTTAAAAGGATGCTTAATCGGGAGCTCACCCATCTCTCTGAAATGAGTCGGT
CTGGAAATCAAGTGTCAGAGTTTATATCAAACACATTCTTAGATAAGCAACATGAAGTGGAAATTCCTTCTCCAACTCAGAAGGAAAAGGAGAAAAAGAAAAGACCAATGTCTCAGATCAGTGGAGTCAAGAAATTGATGCACAGCTCTA
GTCTGACTAATTCAAGTATCCCAAGGTTTGGAGTTAAAACTGAACAAGAAGATGTCCTTGCCAAGGAACTAGAAGATGTGAACAAATGGGGTCTTCATGTTTTCAGAATAGCAGAGTTGTCTGGTAACCGGCCCTTGACTGTTATCATGC
ACACCATTTTTCAGGAACGGGATTTATTAAAAACATTTAAAATTCCAGTAGATACTTTAATTACATATCTTATGACTCTCGAAGACCATTACCATGCTGATGTGGCCTATCACAACAATATCCATGCTGCAGATGTTGTCCAGTCTACTC
ATGTGCTATTATCTACACCTGCTTTGGAGGCTGTGTTTACAGATTTGGAGATTCTTGCAGCAATTTTTGCCAGTGCAATACATGATGTAGATCATCCTGGTGTGTCCAATCAATTTCTGATCAATACAAACTCTGAACTTGCCTTGATGT
ACAATGATTCCTCAGTCTTAGAGAACCATCATTTGGCTGTGGGCTTTAAATTGCTTCAGGAAGAAAACTGTGACATTTTCCAGAATTTGACCAAAAAACAAAGACAATCTTTAAGGAAAATGGTCATTGACATCGTACTTGCAACAGATA
TGTCAAAACACATGAATCTACTGGCTGATTTGAAGACTATGGTTGAAACTAAGAAAGTGACAAGCTCTGGAGTTCTTCTTCTTGATAATTATTCCGATAGGATTCAGGTTCTTCAGAATATGGTGCACTGTGCAGATCTGAGCAACCCAA
CAAAGCCTCTCCAGCTGTACCGCCAGTGGACGGACCGGATAATGGAGGAGTTCTTCCGCCAAGGAGACCGAGAGAGGGAACGTGGCATGGAGATAAGCCCCATGTGTGACAAGCACAATGCTTCCGTGGAAAAATCACAGGTGGGCTTCA
TAGACTATATTGTTCATCCCCTCTGGGAGACATGGGCAGACCTCGTCCACCCTGACGCCCAGGATATTTTGGACACTTTGGAGGACAATCGTGAATGGTACCAGAGCACAATCCCTCAGAGCCCCTCTCCTGCACCTGATGACCCAGAGG
AGGGCCGGCAGGGTCAAACTGAGAAATTCCAGTTTGAACTAACTTTAGAGGAAGATGGTGAGTCAGACACGGAAAAGGACAGTGGCAGTCAAGTGGAAGAAGACACTAGCTGCAGTGACTCCAAGACTCTTTGTACTCAAGACTCAGAGT
CTACTGAAATTCCCCTTGATGAACAGGTTGAAGAGGAGGCAGTAGGGGAAGAAGAGGAAAGCCAGCCTGAAGCCTGTGTCATAGATGATCGTTCTCCTGACACGTAA

>DEPDC1B_PDE4D_ENST00000453022_ENST00000340635_59982788_58511794 length=7956nt 
 Breakpoint=355nt
ATCAGCGCTGGCGCGGCTGCGGCCGCTGCTGCCTACGCGCCATGGAGCATCGCATCGTGGGGCCCGGGCCGTACCGAGCTACCAGGCTGTGGAATGAGACCGTGGAGCTTTTTCGTGCTAAGATGCCGTTACGGAAACATCGCTGTCGTT
TCAAGAGCTATGAGCATTGTTTCACAGCGGCCGAAGCTGTGGATTGGCTGCATGAGCTGCTGAGGTGCAGTCAAAACTTCGGCCCTGAAGTGACCCGCAAACAAACGGTCCAGCTGCTAAAAAAATTCCTGAAGAATCACGTTATTGAAG
ACATCAAGGGAAAATGGGGTGAGGAAGATTTTGAAGACAATCGTCACTTATACAGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCC
ACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGC
GAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGAAACTGGCCAGCGAGACCCTGGAGGAGC
TGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGTTTAAAAGGATGCTTAATCGGGAGCTCACCCATCTCTCTGAAATGAGTCGGTCTGGAAATCAAGTGTCAGAGTTTATAT
CAAACACATTCTTAGATAAGCAACATGAAGTGGAAATTCCTTCTCCAACTCAGAAGGAAAAGGAGAAAAAGAAAAGACCAATGTCTCAGATCAGTGGAGTCAAGAAATTGATGCACAGCTCTAGTCTGACTAATTCAAGTATCCCAAGGT
TTGGAGTTAAAACTGAACAAGAAGATGTCCTTGCCAAGGAACTAGAAGATGTGAACAAATGGGGTCTTCATGTTTTCAGAATAGCAGAGTTGTCTGGTAACCGGCCCTTGACTGTTATCATGCACACCATTTTTCAGGAACGGGATTTAT
TAAAAACATTTAAAATTCCAGTAGATACTTTAATTACATATCTTATGACTCTCGAAGACCATTACCATGCTGATGTGGCCTATCACAACAATATCCATGCTGCAGATGTTGTCCAGTCTACTCATGTGCTATTATCTACACCTGCTTTGG
AGGCTGTGTTTACAGATTTGGAGATTCTTGCAGCAATTTTTGCCAGTGCAATACATGATGTAGATCATCCTGGTGTGTCCAATCAATTTCTGATCAATACAAACTCTGAACTTGCCTTGATGTACAATGATTCCTCAGTCTTAGAGAACC
ATCATTTGGCTGTGGGCTTTAAATTGCTTCAGGAAGAAAACTGTGACATTTTCCAGAATTTGACCAAAAAACAAAGACAATCTTTAAGGAAAATGGTCATTGACATCGTACTTGCAACAGATATGTCAAAACACATGAATCTACTGGCTG
ATTTGAAGACTATGGTTGAAACTAAGAAAGTGACAAGCTCTGGAGTTCTTCTTCTTGATAATTATTCCGATAGGATTCAGGTTCTTCAGAATATGGTGCACTGTGCAGATCTGAGCAACCCAACAAAGCCTCTCCAGCTGTACCGCCAGT
GGACGGACCGGATAATGGAGGAGTTCTTCCGCCAAGGAGACCGAGAGAGGGAACGTGGCATGGAGATAAGCCCCATGTGTGACAAGCACAATGCTTCCGTGGAAAAATCACAGGTGGGCTTCATAGACTATATTGTTCATCCCCTCTGGG
AGACATGGGCAGACCTCGTCCACCCTGACGCCCAGGATATTTTGGACACTTTGGAGGACAATCGTGAATGGTACCAGAGCACAATCCCTCAGAGCCCCTCTCCTGCACCTGATGACCCAGAGGAGGGCCGGCAGGGTCAAACTGAGAAAT
TCCAGTTTGAACTAACTTTAGAGGAAGATGGTGAGTCAGACACGGAAAAGGACAGTGGCAGTCAAGTGGAAGAAGACACTAGCTGCAGTGACTCCAAGACTCTTTGTACTCAAGACTCAGAGTCTACTGAAATTCCCCTTGATGAACAGG
TTGAAGAGGAGGCAGTAGGGGAAGAAGAGGAAAGCCAGCCTGAAGCCTGTGTCATAGATGATCGTTCTCCTGACACGTAACAGTGCAAAAACTTTCATGCCTTTTTTTTTTTTAAGTAGAAAAATTGTTTCCAAAGTGCATGTCACATGC
CACAACCACGGTCACACCTCACTGTCATCTGCCAGGACGTTTGTTGAACAAAACTGACCTTGACTACTCAGTCCAGCGCTCAGGAATATCGTAACCAGTTTTTTCACCTCCATGTCATCCGAGCAAGGTGGACATCTTCACGAACAGCGT
TTTTAACAAGATTTCAGCTTGGTAGAGCTGACAAAGCAGATAAAATCTACTCCAAATTATTTTCAAGAGAGTGTGACTCATCAGGCAGCCCAAAAGTTTATTGGACTTGGGGTTTCTATTCCTTTTTATTTGTTTGCAATATTTTCAGAA
GAAAGGCATTGCACAGAGTGAACTTAATGGACGAAGCAACAAATATGTCAAGAACAGGACATAGCACGAATCTGTTACCAGTAGGAGGAGGATGAGCCACAGAAATTGCATAATTTTCTAATTTCAAGTCTTCCTGATACATGACTGAAT
AGTGTGGTTCAGTGAGCTGCACTGACCTCTACATTTTGTATGATATGTAAAACAGATTTTTTGTAGAGCTTACTTTTATTATTAAATGTATTGAGGTATTATATTTAAAAAAAACTATGTTCAGAACTTCATCTGCCACTGGTTATTTTT
TTCTAAGGAGTAACTTGCAAGTTTTCAGTACAAATCTGTGCTACACTGGATAAAAATCTAATTTATGAATTTTACTTGCACCTTATAGTTCATAGCAATTAACTGATTTGTAGTGATTCATTGTTTGTTTTATATACCAATGACTTCCAT
ATTTTAAAAGAGAAAAACAACTTTATGTTGCAGGAAACCCTTTTTGTAAGTCTTTATTATTTACTTTGCATTTTGTTTCACTCTTTCCAGATAAGCAGAGTTGCTCTTCACCAGTGTTTTTCTTCATGTGCAAAGTGACTATTTGTTCTA
TAATACTTTTATGTGTGTTATATCAAATGTGTCTTAAGCTTCATGCAAACTCAGTCATCAGTTCGTGTTGTCTGAAGCAAGTGGGAGATATATAAATACCCAGTAGCTAAAATGGTCAGTCTTTTTTAGATGTTTTCCTACTTAGTATCT
CCTAATAACGTTTTGCTGTGTCACTAGATGTTCATTTCACAAGTGCATGTCTTTCTAATAATCCACACATTTCATGCTCTAATAATCCACACATTTCATGCTCATTTTTATTGTTTTTACAGCCAGTTATAGTAAGAAAAAGGTTTTTCC
CCTTGTGCTGCTTTATAATTTAGCGTGTGTCTGAACCTTATCCATGTTTGCTAGATGAGGTCTTGTCAAATATATCACTACCATTGTCACCGGTGAAAAGAAACAGGTAGTTAAGTTAGGGTTAACATTCATTTCAACCACGAGGTTGTA
TATCATGACTAGCTTTTACTCTTGGTTTACAGAGAAAAGTTAAACAGCCAACTAGGCAGTTTTTAAGAATATTAACAATATATTAACAAACACCAATACAACTAATCCTATTTGGTTTTAATGATTTCACCATGGGATTAAGAACTATAT
CAGGAACATCCCTGAGAAACGGTTTTAAGTGTAGCAACTACTCTTCCTTAATGGACAGCCACATAACGTGTAGGAAGTCCTTTATCACTTATCCTCGATCCATAAGCATATCTTGCAGAGGGGAACTACTTCTTTAAACACATGGAGGGA
AAGAAGATGATGCCACTGGCACCAGAGGGTTAGTACTGTGATGCATCCTAAAATATTTATTATATTGGTAAAAATTCTGGTTAAATAAAAAATTAGAGATCACTCTTGGCTGATTTCAGCACCAGGAACTGTATTACAGTTTTAGAGATT
AATTCCTAGTGTTTACCTGATTATAGCAGTTGGCATCATGGGGCATTTAATTCTGACTTTATCCCCACGTCAGCCTTAATAAAGTCTTCTTTACCTTCTCTATGAAGACTTTAAAGCCCAAATAATCATTTTTCACATTGATATTCAAGA
ATTGAGATAGATAGAAGCCAAAGTGGGTATCTGACAAGTGGAAAATCAAACGTTTAAGAAGAATTACAACTCTGAAAAGCATTTATATGTGGAACTTCTCAAGGAGCCTCCTGGGGACTGGAAAGTAAGTCATCAGCCAGGCAAATGACT
CATGCTGAAGAGAGTCCCCATTTCAGTCCCCTGAGATCTAGCTGATGCTTAGATCCTTTGAAATAAAAATTATGTCTTTATAACTCTGATCTTTTACATAAAGCAGAAGAGGAATCAACTAGTTAATTGCAAGGTTTCTACTCTGTTTCC
TCTGTAAAGATCAGATGGTAATCTTTCAAATAAGAAAAAAATAAAGACGTATGTTTGACCAAGTAGTTTCACAAGAATATTTGGGAACTTGTTTCTTTTAATTTTATTTGTCCCTGAGTGAAGTCTAGAAAGAAAGGTAAAGAGTCTAGA
GTTTATTCCTCTTTCCAAAACATTCTCATTCCTCTCCTCCCTACACTTAGTATTTCCCCCACAGAGTGCCTAGAATCTTAATAATGAATAAAATAAAAAGCAGCAATATGTCATTAACAAATCCAGACCTGAAAGGGTAAAGGGTTTATA
ACTGCACTAATAAAGAGAGGCTCTTTTTTTTTCTTCCAGTTTGTTGGTTTTTAATGGTACCGTGTTGTAAAGATACCCACTAATGGACAATCAAATTGCAGAAAAGGCTCAATATCCAAGAGACAGGGACTAATGCACTGTACAATCTGC
TTATCCTTGCCCTTCTCTCTTGCCAAAGTGTGCTTCAGAAATATATACTGCTTTAAAAAAGAATAAAAGAATATCCTTTTACAAGTGGCTTTACATTTCCTAAAATGCCATAAGAAAATGCAATATCTGGGTACTGTATGGGGAAAAAAA
TGTCCAAGTTTGTGTAAAACCAGTGCATTTCAGCTTGCAAGTTACTGAACACAATAATGCTGTTTTAATTTTGTTTTATATCAGTTAAAATTCACAATAATGTAGATAGAACAAATTACAGACAAGGAAAGAAAAAACTTGAATGAAATG
GATTTTACAGAAAGCTTTATGATAATTTTTGAATGCATTATTTATTTTTTGTGCCATGCATTTTTTTTCTCACCAAATGACCTTACCTGTAATACAGTCTTGTTTGTCTGTTTACAACCATGTATTTATTGCAATGTACATACTGTAATG
TTAATTGTAAATTATCTGTTCTTATTAAAACATCATCCCATGATGGGATGGTGTTGATATATTTGGAAACTCTTGGTGAGAGAATGAATGGTGTGTATACATACTCTGTACATTTTTCTTTTCTCCTGTAATATAGTCTTGTCACCTTAG
AGCTTGTTTATGGAAGATTCAAGAAAACTATAAAATACTTAAAGATATATAAATTTAAAAAAACATAGCTGCAGGTCTTTGGTCCCAGGGCTGTGCCTTAACTTTAACCAATATTTTCTTCTGTTTTGCTGCATTTGAAAGGTAACAGTG
GAGCTAGGGCTGGGCATTTTACATCCAGGCTTTTAATTGATTAGAATTCTGCCAATAGGTGGATTTTACAAAACCACAGACAACCTCTGAAAGATTCTGAGACCCTTTTGAGACAGAAGCTCTTAAGTACTTCTTGCCAGGGAGCAGCAC
TGCATGTGTGATGGTTGTTTGCCATCTGTTGATCAGGAACTACTTCAGCTACTTGCATTTGATTATTTCCTTTTTTTTTTTTTTTAACTCGGAAACACAACTGGGGAAATATATTCTTTCCCAGTGATTATAAACAATCTTTTTCTTTTT
TTTAAGTCCTTTTGGCTTCTAGAGCTCATAGGAAAATGGACTTGATTTGAAATTGGAGCCAGAGTTTACTCGTGTTGGTTATCTATTCATCAGCTTCCTGACATGTTAAGAGAATACATTAAAGAGAAAATACTGTTTTTTAATCCTAAA
ATTTTTCTTCCACTAAGATAAACCAAATGTCCTTACATATATGTAAACCCATCTATTTAAACGCAAAGGTGGGTTGATGTCAGTTTACATAGCAGAAAGCATTCACTATCCTCTAAGATTTGTTTCTGCAAAACTTTCATTGCTTTAGAA
TTTTAAAATTTCACCTTGTACAATGGCCAGCCCCTAAAGCAGGAAACATTTATAATGGATTATATGGAAACATCCTCCCAGTACTTGCCCAGCCCTTGAATCATGTGGCTTTTCAGTGAAAGGAAAGATTCTTTTTCTAGGAAAAATGAG
CCTATTTTATTTTATTTTATTTTATTTTTTGACACAAACTGTAGATTTTAGCAGCCCTGGCCCAAAGGAATTTGATTACTTTTGTTTTAAACAGTACAAAGGGGACACTATAATTACAAAAACATCCTTAACTGATTTGAGTTGTTTTTA
TTTCTTTGGATATATTTTCAGAGTGGTAAATTGTGTGTGAGAATTACAAATGATTATTCTTTTAGTGGTTTCTTAGCCTCTCTTACAGCCCACGGGGATAGTACTGTACATCAATACCTTCATATGAAATTTTTATATGCAATGAAAATA
AAAGCATGGGTTGATTCTGCCTATTTATGACTCAATCTTTTACAAATAAAAGATTATTCATTTTAAATTATAGTTCAATCAGCATGTCTCTTAGGATACTGAACGTGGTTGAAATGAAAGGATAGTGACATCATAAGTTAGTACTGATAT
TCATAACCAAATAAAGCCAACTTGAGTAATTTTGCTACATTAAAAATTACCAAAATTACTTAGATGGCCTATAAGATTAAGCATGGTGTTTTCTAAGCAAGCTTTGAAAGGGGCCTTCCATACTTACTTAATTGAATATTCTGGGATATT
GAAAATTATTCAGATACTTGACAATTATTTTTGGTTACCTACTCCGCAAACTACAAAGTTTTAAGGACTCAACAATAAGTTAATGAGACACAGTGTTTGCTTTCATGGAGCTTACAGTCTGGAGGGGACAAAGGCTTAAACAATACTCAT
ATAATTATATATGTGATCAGTACAATGAAGGAGCTCAGTGGGGTAAATAAGCAGGAACCTGAACTTGATCTGTTCCGGAGGGCCACAGAAGGCTTCCTTGAGGCCTTGAGAAAGTGATTTGCATCTGAGTTCTGAAGGATTGTAAGAGGT
AACTAGGGAAAAAGTTGACAGGAAGAGGAAGGGGATCCAGACAAGAAACATTTGCAAAGATCTTGAGGCATAAATGAGCTTGAGACATCTGGAGAAACTGAGGAAAAGTGAGAGAGTAGGCAGGGCCTGGAGCCGCAGAGCCATTGCTAA
CCATCCTGTGTGAGATATCCCCCATTCTGTAGCTTTATTCTCATAACCCTGCTCAATTTTCTTTATAACACTTCTCACAGATTTATATACGTGTTTGTTTTTGTTATCTGTCTCTCCCACCAGACCACAGCTCCATGAGAGCAAGGTCTT
TGCTTACCAATATATCACTAGCACTTAAAACTATGCCTGGTACACAGTAGGTTCTTAATATGTGTTGAATATAGCCATCAAATTGATATTGGATATAATTCAATCTGATAAGATATTTTGAGATATTAAAGAGTTTTTAACTTGATACCA
TAAAAA

>DEPDC1B_PDE4D_ENST00000453022_ENST00000360047_59982788_58511794 length=3306nt 
 Breakpoint=355nt
ATCAGCGCTGGCGCGGCTGCGGCCGCTGCTGCCTACGCGCCATGGAGCATCGCATCGTGGGGCCCGGGCCGTACCGAGCTACCAGGCTGTGGAATGAGACCGTGGAGCTTTTTCGTGCTAAGATGCCGTTACGGAAACATCGCTGTCGTT
TCAAGAGCTATGAGCATTGTTTCACAGCGGCCGAAGCTGTGGATTGGCTGCATGAGCTGCTGAGGTGCAGTCAAAACTTCGGCCCTGAAGTGACCCGCAAACAAACGGTCCAGCTGCTAAAAAAATTCCTGAAGAATCACGTTATTGAAG
ACATCAAGGGAAAATGGGGTGAGGAAGATTTTGAAGACAATCGTCACTTATACAGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCC
ACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGC
GAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGAAACTGGCCAGCGAGACCCTGGAGGAGC
TGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGTTTAAAAGGATGCTTAATCGGGAGCTCACCCATCTCTCTGAAATGAGTCGGTCTGGAAATCAAGTGTCAGAGTTTATAT
CAAACACATTCTTAGATAAGCAACATGAAGTGGAAATTCCTTCTCCAACTCAGAAGGAAAAGGAGAAAAAGAAAAGACCAATGTCTCAGATCAGTGGAGTCAAGAAATTGATGCACAGCTCTAGTCTGACTAATTCAAGTATCCCAAGGT
TTGGAGTTAAAACTGAACAAGAAGATGTCCTTGCCAAGGAACTAGAAGATGTGAACAAATGGGGTCTTCATGTTTTCAGAATAGCAGAGTTGTCTGGTAACCGGCCCTTGACTGTTATCATGCACACCATTTTTCAGGAACGGGATTTAT
TAAAAACATTTAAAATTCCAGTAGATACTTTAATTACATATCTTATGACTCTCGAAGACCATTACCATGCTGATGTGGCCTATCACAACAATATCCATGCTGCAGATGTTGTCCAGTCTACTCATGTGCTATTATCTACACCTGCTTTGG
AGGCTGTGTTTACAGATTTGGAGATTCTTGCAGCAATTTTTGCCAGTGCAATACATGATGTAGATCATCCTGGTGTGTCCAATCAATTTCTGATCAATACAAACTCTGAACTTGCCTTGATGTACAATGATTCCTCAGTCTTAGAGAACC
ATCATTTGGCTGTGGGCTTTAAATTGCTTCAGGAAGAAAACTGTGACATTTTCCAGAATTTGACCAAAAAACAAAGACAATCTTTAAGGAAAATGGTCATTGACATCGTACTTGCAACAGATATGTCAAAACACATGAATCTACTGGCTG
ATTTGAAGACTATGGTTGAAACTAAGAAAGTGACAAGCTCTGGAGTTCTTCTTCTTGATAATTATTCCGATAGGATTCAGGTTCTTCAGAATATGGTGCACTGTGCAGATCTGAGCAACCCAACAAAGCCTCTCCAGCTGTACCGCCAGT
GGACGGACCGGATAATGGAGGAGTTCTTCCGCCAAGGAGACCGAGAGAGGGAACGTGGCATGGAGATAAGCCCCATGTGTGACAAGCACAATGCTTCCGTGGAAAAATCACAGGTGGGCTTCATAGACTATATTGTTCATCCCCTCTGGG
AGACATGGGCAGACCTCGTCCACCCTGACGCCCAGGATATTTTGGACACTTTGGAGGACAATCGTGAATGGTACCAGAGCACAATCCCTCAGAGCCCCTCTCCTGCACCTGATGACCCAGAGGAGGGCCGGCAGGGTCAAACTGAGAAAT
TCCAGTTTGAACTAACTTTAGAGGAAGATGGTGAGTCAGACACGGAAAAGGACAGTGGCAGTCAAGTGGAAGAAGACACTAGCTGCAGTGACTCCAAGACTCTTTGTACTCAAGACTCAGAGTCTACTGAAATTCCCCTTGATGAACAGG
TTGAAGAGGAGGCAGTAGGGGAAGAAGAGGAAAGCCAGCCTGAAGCCTGTGTCATAGATGATCGTTCTCCTGACACGTAACAGTGCAAAAACTTTCATGCCTTTTTTTTTTTTAAGTAGAAAAATTGTTTCCAAAGTGCATGTCACATGC
CACAACCACGGTCACACCTCACTGTCATCTGCCAGGACGTTTGTTGAACAAAACTGACCTTGACTACTCAGTCCAGCGCTCAGGAATATCGTAACCAGTTTTTTCACCTCCATGTCATCCGAGCAAGGTGGACATCTTCACGAACAGCGT
TTTTAACAAGATTTCAGCTTGGTAGAGCTGACAAAGCAGATAAAATCTACTCCAAATTATTTTCAAGAGAGTGTGACTCATCAGGCAGCCCAAAAGTTTATTGGACTTGGGGTTTCTATTCCTTTTTATTTGTTTGCAATATTTTCAGAA
GAAAGGCATTGCACAGAGTGAACTTAATGGACGAAGCAACAAATATGTCAAGAACAGGACATAGCACGAATCTGTTACCAGTAGGAGGAGGATGAGCCACAGAAATTGCATAATTTTCTAATTTCAAGTCTTCCTGATACATGACTGAAT
AGTGTGGTTCAGTGAGCTGCACTGACCTCTACATTTTGTATGATATGTAAAACAGATTTTTTGTAGAGCTTACTTTTATTATTAAATGTATTGAGGTATTATATTTAAAAAAAACTATGTTCAGAACTTCATCTGCCACTGGTTATTTTT
TTCTAAGGAGTAACTTGCAAGTTTTCAGTACAAATCTGTGCTACACTGGATAAAAATCTAATTTATGAATTTTACTTGCACCTTATAGTTCATAGCAATTAACTGATTTGTAGTGATTCATTGTTTGTTTTATATACCAATGACTTCCAT
ATTTTAAAAGAGAAAAACAACTTTATGTTGCAGGAAACCCTTTTTGTAAGTCTTTATTATTTACTTTGCATTTTGTTTCACTCTTTCCAGATAAGCAGAGTTGCTCTTCACCAGTGTTTTTCTTCATGTGCAAAGTGACTATTTGTTCTA
TAATAC

>DEPDC1B_PDE4D_ENST00000453022_ENST00000502484_59982788_58511794 length=2337nt 
 Breakpoint=355nt
ATCAGCGCTGGCGCGGCTGCGGCCGCTGCTGCCTACGCGCCATGGAGCATCGCATCGTGGGGCCCGGGCCGTACCGAGCTACCAGGCTGTGGAATGAGACCGTGGAGCTTTTTCGTGCTAAGATGCCGTTACGGAAACATCGCTGTCGTT
TCAAGAGCTATGAGCATTGTTTCACAGCGGCCGAAGCTGTGGATTGGCTGCATGAGCTGCTGAGGTGCAGTCAAAACTTCGGCCCTGAAGTGACCCGCAAACAAACGGTCCAGCTGCTAAAAAAATTCCTGAAGAATCACGTTATTGAAG
ACATCAAGGGAAAATGGGGTGAGGAAGATTTTGAAGACAATCGTCACTTATACAGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCC
ACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGC
GAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGAAACTGGCCAGCGAGACCCTGGAGGAGC
TGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGTTTAAAAGGATGCTTAATCGGGAGCTCACCCATCTCTCTGAAATGAGTCGGTCTGGAAATCAAGTGTCAGAGTTTATAT
CAAACACATTCTTAGATAAGCAACATGAAGTGGAAATTCCTTCTCCAACTCAGAAGGAAAAGGAGAAAAAGAAAAGACCAATGTCTCAGATCAGTGGAGTCAAGAAATTGATGCACAGCTCTAGTCTGACTAATTCAAGTATCCCAAGGT
TTGGAGTTAAAACTGAACAAGAAGATGTCCTTGCCAAGGAACTAGAAGATGTGAACAAATGGGGTCTTCATGTTTTCAGAATAGCAGAGTTGTCTGGTAACCGGCCCTTGACTGTTATCATGCACACCATTTTTCAGGAACGGGATTTAT
TAAAAACATTTAAAATTCCAGTAGATACTTTAATTACATATCTTATGACTCTCGAAGACCATTACCATGCTGATGTGGCCTATCACAACAATATCCATGCTGCAGATGTTGTCCAGTCTACTCATGTGCTATTATCTACACCTGCTTTGG
AGGCTGTGTTTACAGATTTGGAGATTCTTGCAGCAATTTTTGCCAGTGCAATACATGATGTAGATCATCCTGGTGTGTCCAATCAATTTCTGATCAATACAAACTCTGAACTTGCCTTGATGTACAATGATTCCTCAGTCTTAGAGAACC
ATCATTTGGCTGTGGGCTTTAAATTGCTTCAGGAAGAAAACTGTGACATTTTCCAGAATTTGACCAAAAAACAAAGACAATCTTTAAGGAAAATGGTCATTGACATCGTACTTGCAACAGATATGTCAAAACACATGAATCTACTGGCTG
ATTTGAAGACTATGGTTGAAACTAAGAAAGTGACAAGCTCTGGAGTTCTTCTTCTTGATAATTATTCCGATAGGATTCAGGTTCTTCAGAATATGGTGCACTGTGCAGATCTGAGCAACCCAACAAAGCCTCTCCAGCTGTACCGCCAGT
GGACGGACCGGATAATGGAGGAGTTCTTCCGCCAAGGAGACCGAGAGAGGGAACGTGGCATGGAGATAAGCCCCATGTGTGACAAGCACAATGCTTCCGTGGAAAAATCACAGGTGGGCTTCATAGACTATATTGTTCATCCCCTCTGGG
AGACATGGGCAGACCTCGTCCACCCTGACGCCCAGGATATTTTGGACACTTTGGAGGACAATCGTGAATGGTACCAGAGCACAATCCCTCAGAGCCCCTCTCCTGCACCTGATGACCCAGAGGAGGGCCGGCAGGGTCAAACTGAGAAAT
TCCAGTTTGAACTAACTTTAGAGGAAGATGGTGAGTCAGACACGGAAAAGGACAGTGGCAGTCAAGTGGAAGAAGACACTAGCTGCAGTGACTCCAAGACTCTTTGTACTCAAGACTCAGAGTCTACTGAAATTCCCCTTGATGAACAGG
TTGAAGAGGAGGCAGTAGGGGAAGAAGAGGAAAGCCAGCCTGAAGCCTGTGTCATAGATGATCGTTCTCCTGACACGTAACAGTGCA

>DEPDC1B_PDE4D_ENST00000453022_ENST00000502575_59982788_58511794 length=1005nt 
 Breakpoint=355nt
ATCAGCGCTGGCGCGGCTGCGGCCGCTGCTGCCTACGCGCCATGGAGCATCGCATCGTGGGGCCCGGGCCGTACCGAGCTACCAGGCTGTGGAATGAGACCGTGGAGCTTTTTCGTGCTAAGATGCCGTTACGGAAACATCGCTGTCGTT
TCAAGAGCTATGAGCATTGTTTCACAGCGGCCGAAGCTGTGGATTGGCTGCATGAGCTGCTGAGGTGCAGTCAAAACTTCGGCCCTGAAGTGACCCGCAAACAAACGGTCCAGCTGCTAAAAAAATTCCTGAAGAATCACGTTATTGAAG
ACATCAAGGGAAAATGGGGTGAGGAAGATTTTGAAGACAATCGTCACTTATACAGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCC
ACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGC
GAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGGATCCTGGATGGAATTGAACCCATATACGTTACTTGACATGT
GAAACACGTGTGACCCTGGCAGATGATTTGGCTGACCTTGAAAACTACAGCTGTTTAGTCACTTTGAAAACAATGCAATACAAGTGATTTACTAGGCTTCAGTTTTAACCATTTTATGCTGACTGGTGGAAATTCTAACCCTTCAGAAAG
AAAAAAAAATTGTGAAGCAATGGAAATGTACCATCCTGGGTATTAATGTCATTAATTTTCAATACATTTTCTCACAAAAAGTATAAAGAAGTCTTTGCTTGACCT

>DEPDC1B_PDE4D_ENST00000453022_ENST00000507116_59982788_58511794 length=3306nt 
 Breakpoint=355nt
ATCAGCGCTGGCGCGGCTGCGGCCGCTGCTGCCTACGCGCCATGGAGCATCGCATCGTGGGGCCCGGGCCGTACCGAGCTACCAGGCTGTGGAATGAGACCGTGGAGCTTTTTCGTGCTAAGATGCCGTTACGGAAACATCGCTGTCGTT
TCAAGAGCTATGAGCATTGTTTCACAGCGGCCGAAGCTGTGGATTGGCTGCATGAGCTGCTGAGGTGCAGTCAAAACTTCGGCCCTGAAGTGACCCGCAAACAAACGGTCCAGCTGCTAAAAAAATTCCTGAAGAATCACGTTATTGAAG
ACATCAAGGGAAAATGGGGTGAGGAAGATTTTGAAGACAATCGTCACTTATACAGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCC
ACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGC
GAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGAAACTGGCCAGCGAGACCCTGGAGGAGC
TGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGTTTAAAAGGATGCTTAATCGGGAGCTCACCCATCTCTCTGAAATGAGTCGGTCTGGAAATCAAGTGTCAGAGTTTATAT
CAAACACATTCTTAGATAAGCAACATGAAGTGGAAATTCCTTCTCCAACTCAGAAGGAAAAGGAGAAAAAGAAAAGACCAATGTCTCAGATCAGTGGAGTCAAGAAATTGATGCACAGCTCTAGTCTGACTAATTCAAGTATCCCAAGGT
TTGGAGTTAAAACTGAACAAGAAGATGTCCTTGCCAAGGAACTAGAAGATGTGAACAAATGGGGTCTTCATGTTTTCAGAATAGCAGAGTTGTCTGGTAACCGGCCCTTGACTGTTATCATGCACACCATTTTTCAGGAACGGGATTTAT
TAAAAACATTTAAAATTCCAGTAGATACTTTAATTACATATCTTATGACTCTCGAAGACCATTACCATGCTGATGTGGCCTATCACAACAATATCCATGCTGCAGATGTTGTCCAGTCTACTCATGTGCTATTATCTACACCTGCTTTGG
AGGCTGTGTTTACAGATTTGGAGATTCTTGCAGCAATTTTTGCCAGTGCAATACATGATGTAGATCATCCTGGTGTGTCCAATCAATTTCTGATCAATACAAACTCTGAACTTGCCTTGATGTACAATGATTCCTCAGTCTTAGAGAACC
ATCATTTGGCTGTGGGCTTTAAATTGCTTCAGGAAGAAAACTGTGACATTTTCCAGAATTTGACCAAAAAACAAAGACAATCTTTAAGGAAAATGGTCATTGACATCGTACTTGCAACAGATATGTCAAAACACATGAATCTACTGGCTG
ATTTGAAGACTATGGTTGAAACTAAGAAAGTGACAAGCTCTGGAGTTCTTCTTCTTGATAATTATTCCGATAGGATTCAGGTTCTTCAGAATATGGTGCACTGTGCAGATCTGAGCAACCCAACAAAGCCTCTCCAGCTGTACCGCCAGT
GGACGGACCGGATAATGGAGGAGTTCTTCCGCCAAGGAGACCGAGAGAGGGAACGTGGCATGGAGATAAGCCCCATGTGTGACAAGCACAATGCTTCCGTGGAAAAATCACAGGTGGGCTTCATAGACTATATTGTTCATCCCCTCTGGG
AGACATGGGCAGACCTCGTCCACCCTGACGCCCAGGATATTTTGGACACTTTGGAGGACAATCGTGAATGGTACCAGAGCACAATCCCTCAGAGCCCCTCTCCTGCACCTGATGACCCAGAGGAGGGCCGGCAGGGTCAAACTGAGAAAT
TCCAGTTTGAACTAACTTTAGAGGAAGATGGTGAGTCAGACACGGAAAAGGACAGTGGCAGTCAAGTGGAAGAAGACACTAGCTGCAGTGACTCCAAGACTCTTTGTACTCAAGACTCAGAGTCTACTGAAATTCCCCTTGATGAACAGG
TTGAAGAGGAGGCAGTAGGGGAAGAAGAGGAAAGCCAGCCTGAAGCCTGTGTCATAGATGATCGTTCTCCTGACACGTAACAGTGCAAAAACTTTCATGCCTTTTTTTTTTTTAAGTAGAAAAATTGTTTCCAAAGTGCATGTCACATGC
CACAACCACGGTCACACCTCACTGTCATCTGCCAGGACGTTTGTTGAACAAAACTGACCTTGACTACTCAGTCCAGCGCTCAGGAATATCGTAACCAGTTTTTTCACCTCCATGTCATCCGAGCAAGGTGGACATCTTCACGAACAGCGT
TTTTAACAAGATTTCAGCTTGGTAGAGCTGACAAAGCAGATAAAATCTACTCCAAATTATTTTCAAGAGAGTGTGACTCATCAGGCAGCCCAAAAGTTTATTGGACTTGGGGTTTCTATTCCTTTTTATTTGTTTGCAATATTTTCAGAA
GAAAGGCATTGCACAGAGTGAACTTAATGGACGAAGCAACAAATATGTCAAGAACAGGACATAGCACGAATCTGTTACCAGTAGGAGGAGGATGAGCCACAGAAATTGCATAATTTTCTAATTTCAAGTCTTCCTGATACATGACTGAAT
AGTGTGGTTCAGTGAGCTGCACTGACCTCTACATTTTGTATGATATGTAAAACAGATTTTTTGTAGAGCTTACTTTTATTATTAAATGTATTGAGGTATTATATTTAAAAAAAACTATGTTCAGAACTTCATCTGCCACTGGTTATTTTT
TTCTAAGGAGTAACTTGCAAGTTTTCAGTACAAATCTGTGCTACACTGGATAAAAATCTAATTTATGAATTTTACTTGCACCTTATAGTTCATAGCAATTAACTGATTTGTAGTGATTCATTGTTTGTTTTATATACCAATGACTTCCAT
ATTTTAAAAGAGAAAAACAACTTTATGTTGCAGGAAACCCTTTTTGTAAGTCTTTATTATTTACTTTGCATTTTGTTTCACTCTTTCCAGATAAGCAGAGTTGCTCTTCACCAGTGTTTTTCTTCATGTGCAAAGTGACTATTTGTTCTA
TAATAC

>DEPDC1B_PDE4D_ENST00000453022_ENST00000546160_59982788_58511794 length=2330nt 
 Breakpoint=355nt
ATCAGCGCTGGCGCGGCTGCGGCCGCTGCTGCCTACGCGCCATGGAGCATCGCATCGTGGGGCCCGGGCCGTACCGAGCTACCAGGCTGTGGAATGAGACCGTGGAGCTTTTTCGTGCTAAGATGCCGTTACGGAAACATCGCTGTCGTT
TCAAGAGCTATGAGCATTGTTTCACAGCGGCCGAAGCTGTGGATTGGCTGCATGAGCTGCTGAGGTGCAGTCAAAACTTCGGCCCTGAAGTGACCCGCAAACAAACGGTCCAGCTGCTAAAAAAATTCCTGAAGAATCACGTTATTGAAG
ACATCAAGGGAAAATGGGGTGAGGAAGATTTTGAAGACAATCGTCACTTATACAGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCC
ACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGC
GAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGAAACTGGCCAGCGAGACCCTGGAGGAGC
TGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGTTTAAAAGGATGCTTAATCGGGAGCTCACCCATCTCTCTGAAATGAGTCGGTCTGGAAATCAAGTGTCAGAGTTTATAT
CAAACACATTCTTAGATAAGCAACATGAAGTGGAAATTCCTTCTCCAACTCAGAAGGAAAAGGAGAAAAAGAAAAGACCAATGTCTCAGATCAGTGGAGTCAAGAAATTGATGCACAGCTCTAGTCTGACTAATTCAAGTATCCCAAGGT
TTGGAGTTAAAACTGAACAAGAAGATGTCCTTGCCAAGGAACTAGAAGATGTGAACAAATGGGGTCTTCATGTTTTCAGAATAGCAGAGTTGTCTGGTAACCGGCCCTTGACTGTTATCATGCACACCATTTTTCAGGAACGGGATTTAT
TAAAAACATTTAAAATTCCAGTAGATACTTTAATTACATATCTTATGACTCTCGAAGACCATTACCATGCTGATGTGGCCTATCACAACAATATCCATGCTGCAGATGTTGTCCAGTCTACTCATGTGCTATTATCTACACCTGCTTTGG
AGGCTGTGTTTACAGATTTGGAGATTCTTGCAGCAATTTTTGCCAGTGCAATACATGATGTAGATCATCCTGGTGTGTCCAATCAATTTCTGATCAATACAAACTCTGAACTTGCCTTGATGTACAATGATTCCTCAGTCTTAGAGAACC
ATCATTTGGCTGTGGGCTTTAAATTGCTTCAGGAAGAAAACTGTGACATTTTCCAGAATTTGACCAAAAAACAAAGACAATCTTTAAGGAAAATGGTCATTGACATCGTACTTGCAACAGATATGTCAAAACACATGAATCTACTGGCTG
ATTTGAAGACTATGGTTGAAACTAAGAAAGTGACAAGCTCTGGAGTTCTTCTTCTTGATAATTATTCCGATAGGATTCAGGTTCTTCAGAATATGGTGCACTGTGCAGATCTGAGCAACCCAACAAAGCCTCTCCAGCTGTACCGCCAGT
GGACGGACCGGATAATGGAGGAGTTCTTCCGCCAAGGAGACCGAGAGAGGGAACGTGGCATGGAGATAAGCCCCATGTGTGACAAGCACAATGCTTCCGTGGAAAAATCACAGGTGGGCTTCATAGACTATATTGTTCATCCCCTCTGGG
AGACATGGGCAGACCTCGTCCACCCTGACGCCCAGGATATTTTGGACACTTTGGAGGACAATCGTGAATGGTACCAGAGCACAATCCCTCAGAGCCCCTCTCCTGCACCTGATGACCCAGAGGAGGGCCGGCAGGGTCAAACTGAGAAAT
TCCAGTTTGAACTAACTTTAGAGGAAGATGGTGAGTCAGACACGGAAAAGGACAGTGGCAGTCAAGTGGAAGAAGACACTAGCTGCAGTGACTCCAAGACTCTTTGTACTCAAGACTCAGAGTCTACTGAAATTCCCCTTGATGAACAGG
TTGAAGAGGAGGCAGTAGGGGAAGAAGAGGAAAGCCAGCCTGAAGCCTGTGTCATAGATGATCGTTCTCCTGACACGTAA

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for DEPDC1B_PDE4D

In-frame Fusion Protein Sequences.

>DEPDC1B_PDE4D_ENST00000265036_ENST00000340635_59982788_58511794 length=367nt
MEHRIVGPGPYRATRLWNETVELFRAKMPLRKHRCRFKSYEHCFTAAEAVDWLHELLRCSQNFGPEVTRKQTVQLLKKFLKNHVIEDIKGKWGEEDFEDNRHLYRFPPSSPLKPYPKKPPNQKDVIKFPEWNDLPPGTSQENIPVRPVVM
NSEMWYKRHSIAIGEVPACRLVHRRQLTEANVEEIWKSMTLSYLQKILGLDSLEEVLDVKLVNSKFIIHNVYSVSKQGVVILDDKSKELPHWVLSAMKCLANCGLGTFHALLNTAVHVVMYSYYGLSALGPAYQKYLWWKKYLTSLQLVQ
FVIVAIHISQFFFMEDCKYQFPVFACIIMSYSFMFLLLFLHFWYRAYTKGQRLPKTVKNGTCKNKDN

>DEPDC1B_PDE4D_ENST00000265036_ENST00000360047_59982788_58511794 length=762nt
MEHRIVGPGPYRATRLWNETVELFRAKMPLRKHRCRFKSYEHCFTAAEAVDWLHELLRCSQNFGPEVTRKQTVQLLKKFLKNHVIEDIKGKWGEEDFEDNRHLYSFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDS
DYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIP
SPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIF
ASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGD
RERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQP
EACVIDDRSPDT

>DEPDC1B_PDE4D_ENST00000265036_ENST00000502484_59982788_58511794 length=762nt
MEHRIVGPGPYRATRLWNETVELFRAKMPLRKHRCRFKSYEHCFTAAEAVDWLHELLRCSQNFGPEVTRKQTVQLLKKFLKNHVIEDIKGKWGEEDFEDNRHLYSFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDS
DYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIP
SPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIF
ASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGD
RERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQP
EACVIDDRSPDT

>DEPDC1B_PDE4D_ENST00000265036_ENST00000502575_59982788_58511794 length=763nt
MEHRIVGPGPYRATRLWNETVELFRAKMPLRKHRCRFKSYEHCFTAAEAVDWLHELLRCSQNFGPEVTRKQTVQLLKKFLKNHVIEDIKGKWGEEDFEDNRHLYSFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDS
DYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIP
SPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIF
ASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGD
RERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQP
EACVIDDRSPDTX

>DEPDC1B_PDE4D_ENST00000265036_ENST00000507116_59982788_58511794 length=762nt
MEHRIVGPGPYRATRLWNETVELFRAKMPLRKHRCRFKSYEHCFTAAEAVDWLHELLRCSQNFGPEVTRKQTVQLLKKFLKNHVIEDIKGKWGEEDFEDNRHLYSFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDS
DYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIP
SPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIF
ASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGD
RERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQP
EACVIDDRSPDT

>DEPDC1B_PDE4D_ENST00000265036_ENST00000546160_59982788_58511794 length=762nt
MEHRIVGPGPYRATRLWNETVELFRAKMPLRKHRCRFKSYEHCFTAAEAVDWLHELLRCSQNFGPEVTRKQTVQLLKKFLKNHVIEDIKGKWGEEDFEDNRHLYSFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDS
DYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIP
SPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIF
ASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGD
RERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQP
EACVIDDRSPDT

>DEPDC1B_PDE4D_ENST00000453022_ENST00000340635_59982788_58511794 length=236nt
MEHRIVGPGPYRATRLWNETVELFRAKMPLRKHRCRFKSYEHCFTAAEAVDWLHELLRCSQNFGPEVTRKQTVQLLKKFLKNHVIEDIKGKWGEEDFEDNRHLYSFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDS
DYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITGSWMELNPYTLLDM

>DEPDC1B_PDE4D_ENST00000453022_ENST00000360047_59982788_58511794 length=762nt
MEHRIVGPGPYRATRLWNETVELFRAKMPLRKHRCRFKSYEHCFTAAEAVDWLHELLRCSQNFGPEVTRKQTVQLLKKFLKNHVIEDIKGKWGEEDFEDNRHLYSFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDS
DYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIP
SPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIF
ASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGD
RERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQP
EACVIDDRSPDT

>DEPDC1B_PDE4D_ENST00000453022_ENST00000502484_59982788_58511794 length=762nt
MEHRIVGPGPYRATRLWNETVELFRAKMPLRKHRCRFKSYEHCFTAAEAVDWLHELLRCSQNFGPEVTRKQTVQLLKKFLKNHVIEDIKGKWGEEDFEDNRHLYSFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDS
DYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIP
SPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIF
ASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGD
RERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQP
EACVIDDRSPDT

>DEPDC1B_PDE4D_ENST00000453022_ENST00000502575_59982788_58511794 length=763nt
MEHRIVGPGPYRATRLWNETVELFRAKMPLRKHRCRFKSYEHCFTAAEAVDWLHELLRCSQNFGPEVTRKQTVQLLKKFLKNHVIEDIKGKWGEEDFEDNRHLYSFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDS
DYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIP
SPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIF
ASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGD
RERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQP
EACVIDDRSPDTX

>DEPDC1B_PDE4D_ENST00000453022_ENST00000507116_59982788_58511794 length=762nt
MEHRIVGPGPYRATRLWNETVELFRAKMPLRKHRCRFKSYEHCFTAAEAVDWLHELLRCSQNFGPEVTRKQTVQLLKKFLKNHVIEDIKGKWGEEDFEDNRHLYSFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDS
DYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIP
SPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIF
ASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGD
RERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQP
EACVIDDRSPDT

>DEPDC1B_PDE4D_ENST00000453022_ENST00000546160_59982788_58511794 length=762nt
MEHRIVGPGPYRATRLWNETVELFRAKMPLRKHRCRFKSYEHCFTAAEAVDWLHELLRCSQNFGPEVTRKQTVQLLKKFLKNHVIEDIKGKWGEEDFEDNRHLYSFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDS
DYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIP
SPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIF
ASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGD
RERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQP
EACVIDDRSPDT

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for DEPDC1B_PDE4D

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for DEPDC1B_PDE4D

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		BLCA	TCGA-CU-A3KJ-01A	DEPDC1B	chr5	59938638	-	PDE4D	chr5	59481514	-
ChimerDB		BLCA	TCGA-CU-A3KJ	DEPDC1B	chr5	59938638	-	PDE4D	chr5	59481514	-
ChimerDB		BRCA	TCGA-AC-A2BK-01A	DEPDC1B	chr5	59982788	-	PDE4D	chr5	59481514	-
ChimerDB		LIHC	TCGA-CC-A5UC-01A	DEPDC1B	chr5	59982788	-	PDE4D	chr5	59284544	-
cBioPortal	CCLE_GENENTECH_2014	MIXED	S-RMG-I	DEPDC1B	chr5	59982789		PDE4D	chr5	58511794

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for DEPDC1B_PDE4D

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status