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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene Breakpoints

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness

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Fusion Genomic Features

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Fusion Gene ORF Annotations

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Fusion Protein Retained/Non-Retained Functional Features

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Fusion Transcript Sequences

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Fusion Protein Sequences

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Personalized Fusion Protein Sequences

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Fusion Gene Expressed Samples

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Related Drugs

Fusion gene:CTNNBIP1_UBE4B (FusionGDB2 ID:HG56998TG10277)

Fusion Gene Summary for CTNNBIP1_UBE4B

check button Fusion gene summary
Fusion gene informationFusion gene name: CTNNBIP1_UBE4B
Fusion gene ID: hg56998tg10277
HgeneTgene
Gene symbol

CTNNBIP1

UBE4B

Gene ID

56998

10277

Gene namecatenin beta interacting protein 1ubiquitination factor E4B
SynonymsICATE4|HDNB1|UBOX3|UFD2|UFD2A
Cytomap

1p36.22

1p36.22

Type of geneprotein-codingprotein-coding
Descriptionbeta-catenin-interacting protein 1beta-catenin-interacting protein ICATinhibitor of beta-catenin and Tcf-4ubiquitin conjugation factor E4 BRING-type E3 ubiquitin transferase E4 Bhomologous to yeast UFD2homozygously deleted in neuroblastoma-1ubiquitin-fusion degradation protein 2ubiquitination factor E4B (UFD2 homolog, yeast)
Modification date2024030520240403
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000377263, ENST00000400904, 
ENST00000377256, ENST00000377258, 
ENST00000537447, 
Fusion gene scores* DoF score* DoF score (Degree of Frequency) = # partners X # break points X # disease types
11 X 11 X 10=1210		* DoF score (Degree of Frequency) = # partners X # break points X # disease types
6 X 23 X 14=1932
# samples 90128
** MAII score** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)
log2(901/1210*10)=2.89652005853894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)
log2(28/1932*10)=-2.78659636189081
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTNNBIP1 [Title/Abstract] AND UBE4B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCTNNBIP1(9970152)-UBE4B(10238701), # samples:1


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Fusion Gene Breakpoints for CTNNBIP1_UBE4B


check button RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.
HgeneHchrHbpTgeneTchrTbp
CTNNBIP1chr19970152UBE4Bchr110238701
CTNNBIP1chr19970152UBE4Bchr19970152
CTNNBIP1chr19970153UBE4Bchr110238702
CTNNBIP1chr19910095UBE4Bchr110178644


check button DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.
HgeneHchrHbpTgeneTchrTbpSV type
CTNNBIP1chr19925714UBE4Bchr110147796DEL
CTNNBIP1chr19963962UBE4Bchr110118393DUP
CTNNBIP1chr19961543UBE4Bchr110122905DUP
CTNNBIP1chr19935487UBE4Bchr110100879DUP
CTNNBIP1chr19926020UBE4Bchr110120793DEL
CTNNBIP1chr19926020UBE4Bchr110094313DEL
CTNNBIP1chr19942118UBE4Bchr110120793DUP
CTNNBIP1chr19942118UBE4Bchr110120793DEL
CTNNBIP1chr19942118UBE4Bchr110193026DUP


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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for CTNNBIP1_UBE4B


check button To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.
* We have 10 tumorigenic mechanism categories of fusion genes as shown below.
Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand FusionsAberrant Chimeric Transcription Factor / Fusion Transcription Factor ActivityEpigenetic Reprogramming / Histone Modifier DysregulationChromatin Remodeling DysregulationCondensate-Driven Transcriptional Rewiring / LLPPromoter / Enhancer HijackingDominant-Negative AntagonismCell Cycle / Checkpoint Bypass / RNA Processing DysregulationSubcellular Mislocalization / Spatial DysregulationNuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.
Fusion Gene NameMechanism CategoryMechanism PubMedTumorigenic ScenariosTumorigenic Scenario PubMedTargeting PointsTargeting PubMedMechanism BackgroundMechanism Background PubMed
CTNNBIP1-UBE4B
Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation
M8		Promoter swap drives UBE4B U-box E3/E4 ubiquitin ligase expression, accelerating polyubiquitination and degradation of p53.Proteasome inhibitors; p53-MDM2 modulatorsp53-wild-type solid tumors and neuroblastoma

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.
Fusion Gene NameMechanism CategoryMechanism PubMedTumorigenic ScenariosTumorigenic Scenario PubMedTargeting PointsTargeting PubMedMechanism BackgroundMechanism Background PubMed
CTNNBIP1-UBE4B
Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation
M8		Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 35996826; Title: SF3B4 Depletion Retards the Growth of A549 Non-Small Cell Lung Cancer Cells via UBE4B-Mediated Regulation of p53/p21 and p27 Expression.Promoter swap drives UBE4B U-box E3/E4 ubiquitin ligase expression, accelerating polyubiquitination and degradation of p53.Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 35996826; Title: SF3B4 Depletion Retards the Growth of A549 Non-Small Cell Lung Cancer Cells via UBE4B-Mediated Regulation of p53/p21 and p27 Expression.Proteasome inhibitors; p53-MDM2 modulatorsp53-wild-type solid tumors and neuroblastomaEvidence level: Limited indirect gene evidence; Confidence: Low; PMID: 31475882; Title: Low UBE4B expression increases sensitivity of chemoresistant neuroblastoma cells to EGFR and STAT5 inhibition.

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTNNBIP1

GO:0032091

negative regulation of protein binding

12408825|18287330

TgeneUBE4B

GO:0008626

granzyme-mediated apoptotic signaling pathway

11802788

TgeneUBE4B

GO:0009411

response to UV

11802788

TgeneUBE4B

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

23509263


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Fusion Genomic Features for CTNNBIP1_UBE4B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CTNNBIP1chr19970152-UBE4Bchr110238701+1.07e-081.00e+00


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CTNNBIP1chr19970152-UBE4Bchr110238701+1.07e-081.00e+00

check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).
genomic feature

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Fusion Gene ORF Annotations for CTNNBIP1_UBE4B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000377263ENST00000253251CTNNBIP1chr1

9970152

-UBE4Bchr1

10238701

+
5UTR-3CDSENST00000377263ENST00000343090CTNNBIP1chr1

9970152

-UBE4Bchr1

10238701

+
5UTR-3CDSENST00000377263ENST00000377157CTNNBIP1chr1

9970152

-UBE4Bchr1

10238701

+
5UTR-3CDSENST00000400904ENST00000253251CTNNBIP1chr1

9970152

-UBE4Bchr1

10238701

+
5UTR-3CDSENST00000400904ENST00000343090CTNNBIP1chr1

9970152

-UBE4Bchr1

10238701

+
5UTR-3CDSENST00000400904ENST00000377157CTNNBIP1chr1

9970152

-UBE4Bchr1

10238701

+

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)
ENST00000377263ENST00000253251CTNNBIP1chr19970152UBE4Bchr1102387010122
ENST00000377263ENST00000343090CTNNBIP1chr19970152UBE4Bchr1102387010184
ENST00000377263ENST00000377157CTNNBIP1chr19970152UBE4Bchr1102387010313
ENST00000400904ENST00000253251CTNNBIP1chr19970152UBE4Bchr110238701030
ENST00000400904ENST00000343090CTNNBIP1chr19970152UBE4Bchr1102387010184
ENST00000400904ENST00000377157CTNNBIP1chr19970152UBE4Bchr1102387010313

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score
ENST00000377263ENST00000253251CTNNBIP1chr19970152UBE4Bchr1102387010.00e+001.50e-02
ENST00000377263ENST00000343090CTNNBIP1chr19970152UBE4Bchr1102387010.00e+001.43e-01
ENST00000377263ENST00000377157CTNNBIP1chr19970152UBE4Bchr1102387010.00e+001.13e-01
ENST00000400904ENST00000253251CTNNBIP1chr19970152UBE4Bchr1102387010.00e+001.50e-02
ENST00000400904ENST00000343090CTNNBIP1chr19970152UBE4Bchr1102387010.00e+001.43e-01
ENST00000400904ENST00000377157CTNNBIP1chr19970152UBE4Bchr1102387010.00e+001.13e-01

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score

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Fusion Protein Retained/Non-Retained Functional Features for CTNNBIP1_UBE4B

check buttonProtein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.
fgviewer annotation
- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).
No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


check button - Retained PPIs in in-frame fusion.
PartnerHgeneHbpTgeneTbpENSTUniProtStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerHgeneHbpTgeneTbpENSTUniProtStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Fusion Transcript Sequence for CTNNBIP1_UBE4B

check button In-frame Fusion Transcript Sequences.

check button N-Truncated Transcript (5UTR-3CDS) Sequences
>CTNNBIP1_UBE4B_ENST00000377263_ENST00000253251_9970152_10238701 length=795nt
Breakpoint=0nt
AGATCCTACAGTAAGGAATTGTTTGAAGAAGTTATTTCAAAGATGCGGAAGGCAGGGATCAAATCCACAATAGCAATAGAAAAATTTAAGCTGCTCGCCGAGAAAGTGGAGGAGATAGTGGCCAAGAACGCACGCGCAGAAATCGACTAC
AGCGACGCTCCTGATGAGTTCAGAGACCCTCTGATGGACACCCTCATGACAGACCCCGTGCGGCTGCCCTCTGGCACCATCATGGACCGCTCCATCATCCTGCGGCACCTGCTCAACTCCCCCACGGACCCCTTCAACCGGCAGACGCTG
ACAGAGAGCATGCTGGAACCAGTGCCAGAACTGAAAGAGCAGATTCAGGCGTGGATGAGAGAGAAACAGAACAGCGATCACTAAACCGTTCCGCCGCCCACCCTCTGCTAGACACAGCCAAGGCCAACGAGGCAAGCAGAAGCAGCGGCC
GCAGCGAAGCTGCCGTTCATGTGTTGGAGGCCAAATGTGGCAAACCAACCCCAGGCCCACCCAGAGCGAGCAAACGCTGAGACCTGAAAGGACATGGATGAGAAGAGGAGCCCGCTTCCTGTACATATATTTAAGTGACAAACACGGTCA
AAAGCTTAAGGGACAGGTTTTATGGTTGCTTGTGTAATAAAGCATGTCCTTCGTATGTCACAGTTTGGGGCAACGGAAGTCTTTTAGTGATGGCTAATGGGTCTGGGCAGCATCCCTTCATGAATTTTTTTTTAATCCAATATCCGTTGA
TTTGATTGTGATTAGAGAACCTTGGACATTTTGCTGCTAAAGAAT

>CTNNBIP1_UBE4B_ENST00000377263_ENST00000343090_9970152_10238701 length=1667nt
Breakpoint=0nt
AGATCCTACAGTAAGGAATTGTTTGAAGAAGTTATTTCAAAGATGCGGAAGGCAGGGATCAAATCCACAATAGCAATAGAAAAATTTAAGCTGCTCGCCGAGAAAGTGGAGGAGATAGTGGCCAAGAACGCACGCGCAGAAATCGACTAC
AGCGACGCTCCTGATGAGTTCAGAGACCCTCTGATGGACACCCTCATGACAGACCCCGTGCGGCTGCCCTCTGGCACCATCATGGACCGCTCCATCATCCTGCGGCACCTGCTCAACTCCCCCACGGACCCCTTCAACCGGCAGACGCTG
ACAGAGAGCATGCTGGAACCAGTGCCAGAACTGAAAGAGCAGATTCAGGCGTGGATGAGAGAGAAACAGAACAGCGATCACTAAACCGTTCCGCCGCCCACCCTCTGCTAGACACAGCCAAGGCCAACGAGGCAAGCAGAAGCAGCGGCC
GCAGCGAAGCTGCCGTTCATGTGTTGGAGGCCAAATGTGGCAAACCAACCCCAGGCCCACCCAGAGCGAGCAAACGCTGAGACCTGAAAGGACATGGATGAGAAGAGGAGCCCGCTTCCTGTACATATATTTAAGTGACAAACACGGTCA
AAAGCTTAAGGGACAGGTTTTATGGTTGCTTGTGTAATAAAGCATGTCCTTCGTATGTCACAGTTTGGGGCAACGGAAGTCTTTTAGTGATGGCTAATGGGTCTGGGCAGCATCCCTTCATGAATTTTTTTTTAATCCAATATCCGTTGA
TTTGATTGTGATTAGAGAACCTTGGACATTTTGCTGCTAAAGAATCTTTTTTCCCCTCTCCCCCTTCCTGACCCTACTTGCACTGCTGTGGATTTTTTTAAGAGAAGCAAAAACAAAAGTAAACTCCTTTCCCTGGCCCTCCAAACATAT
ATTCTGTGAGATAACTGTGCCTGCTACCAAGTGTTAATCCTGGGATCGTATTTTTATATCATATTCACATATTTGTTTTTTTAATTGGTGTTAGATGACATGATTAATAAAAAAGGCAAGATATTTTCAGAATTTGAATTTCAGTTTTTT
TTTTCTTTTGAAATGTCCCTTTAAGATTTTTTTATTCTAAACAAAATAAAGAAAATCCTGCTGCTCTGGTCCTTGTGATAAGCCTCTCTTCGGCATCTGAGGAGCAGCTGCAGCAAAATCTAGGGGTGTAAGTGTATCAGGACTTATGTG
ACTTATATTTTGGGGAGATGAGGGTTGGGTTTTTTTTTTAATGCTACGTGACAGTTTGAAACCTTCACAGTTATCCTCTGGGGGTAAATCAATTCTTCAACCCTTGGGTGTGTGAGTTTGAGGCAGGGTCATTTGTGTGATGTGTTTGGC
CTTACCAAAGCAAAAGAGGGTGCAAGAATGTGGGAGTATGTCTGCCGGTTTCAACACACACAGACAAACACAGCCACACGCGCACACAAGTATAAGACTTTTTGTATTACTGCTCCCTACTTAACATACTTGAATTCTCAAATTTCCTTT
GGGGTAAAAAAAAAAAAAGGATTTGAAACCATAAAGTGTTCTGAAGAAATTAAGTCTATAAAAAGCATACTTTCTTTTTTCTTTTCCTTTTTTCCCTCCACAGACAATGTCCTCTGTTCAATTCCTAACGCAAACTACAATAAATGGTGA
CACACGTTCAGAAGAAA

>CTNNBIP1_UBE4B_ENST00000377263_ENST00000377157_9970152_10238701 length=1671nt
Breakpoint=0nt
AGATCCTACAGTAAGGAATTGTTTGAAGAAGTTATTTCAAAGATGCGGAAGGCAGGGATCAAATCCACAATAGCAATAGAAAAATTTAAGCTGCTCGCCGAGAAAGTGGAGGAGATAGTGGCCAAGAACGCACGCGCAGAAATCGACTAC
AGCGACGCTCCTGATGAGTTCAGAGGCAAGTGGACTCACCCTCTGATGGACACCCTCATGACAGACCCCGTGCGGCTGCCCTCTGGCACCATCATGGACCGCTCCATCATCCTGCGGCACCTGCTCAACTCCCCCACGGACCCCTTCAAC
CGGCAGACGCTGACAGAGAGCATGCTGGAACCAGTGCCAGAACTGAAAGAGCAGATTCAGGCGTGGATGAGAGAGAAACAGAACAGCGATCACTAAACCGTTCCGCCGCCCACCCTCTGCTAGACACAGCCAAGGCCAACGAGGCAAGCA
GAAGCAGCGGCCGCAGCGAAGCTGCCGTTCATGTGTTGGAGGCCAAATGTGGCAAACCAACCCCAGGCCCACCCAGAGCGAGCAAACGCTGAGACCTGAAAGGACATGGATGAGAAGAGGAGCCCGCTTCCTGTACATATATTTAAGTGA
CAAACACGGTCAAAAGCTTAAGGGACAGGTTTTATGGTTGCTTGTGTAATAAAGCATGTCCTTCGTATGTCACAGTTTGGGGCAACGGAAGTCTTTTAGTGATGGCTAATGGGTCTGGGCAGCATCCCTTCATGAATTTTTTTTTAATCC
AATATCCGTTGATTTGATTGTGATTAGAGAACCTTGGACATTTTGCTGCTAAAGAATCTTTTTTCCCCTCTCCCCCTTCCTGACCCTACTTGCACTGCTGTGGATTTTTTTAAGAGAAGCAAAAACAAAAGTAAACTCCTTTCCCTGGCC
CTCCAAACATATATTCTGTGAGATAACTGTGCCTGCTACCAAGTGTTAATCCTGGGATCGTATTTTTATATCATATTCACATATTTGTTTTTTTAATTGGTGTTAGATGACATGATTAATAAAAAAGGCAAGATATTTTCAGAATTTGAA
TTTCAGTTTTTTTTTTCTTTTGAAATGTCCCTTTAAGATTTTTTTATTCTAAACAAAATAAAGAAAATCCTGCTGCTCTGGTCCTTGTGATAAGCCTCTCTTCGGCATCTGAGGAGCAGCTGCAGCAAAATCTAGGGGTGTAAGTGTATC
AGGACTTATGTGACTTATATTTTGGGGAGATGAGGGTTGGGTTTTTTTTTTAATGCTACGTGACAGTTTGAAACCTTCACAGTTATCCTCTGGGGGTAAATCAATTCTTCAACCCTTGGGTGTGTGAGTTTGAGGCAGGGTCATTTGTGT
GATGTGTTTGGCCTTACCAAAGCAAAAGAGGGTGCAAGAATGTGGGAGTATGTCTGCCGGTTTCAACACACACAGACAAACACAGCCACACGCGCACACAAGTATAAGACTTTTTGTATTACTGCTCCCTACTTAACATACTTGAATTCT
CAAATTTCCTTTGGGGTAAAAAAAAAAAAAGGATTTGAAACCATAAAGTGTTCTGAAGAAATTAAGTCTATAAAAAGCATACTTTCTTTTTTCTTTTCCTTTTTTCCCTCCACAGACAATGTCCTCTGTTCAATTCCTAACGCAAACTAC
AATAAATGGTGACACACGTTC

>CTNNBIP1_UBE4B_ENST00000400904_ENST00000253251_9970152_10238701 length=795nt
Breakpoint=0nt
AGATCCTACAGTAAGGAATTGTTTGAAGAAGTTATTTCAAAGATGCGGAAGGCAGGGATCAAATCCACAATAGCAATAGAAAAATTTAAGCTGCTCGCCGAGAAAGTGGAGGAGATAGTGGCCAAGAACGCACGCGCAGAAATCGACTAC
AGCGACGCTCCTGATGAGTTCAGAGACCCTCTGATGGACACCCTCATGACAGACCCCGTGCGGCTGCCCTCTGGCACCATCATGGACCGCTCCATCATCCTGCGGCACCTGCTCAACTCCCCCACGGACCCCTTCAACCGGCAGACGCTG
ACAGAGAGCATGCTGGAACCAGTGCCAGAACTGAAAGAGCAGATTCAGGCGTGGATGAGAGAGAAACAGAACAGCGATCACTAAACCGTTCCGCCGCCCACCCTCTGCTAGACACAGCCAAGGCCAACGAGGCAAGCAGAAGCAGCGGCC
GCAGCGAAGCTGCCGTTCATGTGTTGGAGGCCAAATGTGGCAAACCAACCCCAGGCCCACCCAGAGCGAGCAAACGCTGAGACCTGAAAGGACATGGATGAGAAGAGGAGCCCGCTTCCTGTACATATATTTAAGTGACAAACACGGTCA
AAAGCTTAAGGGACAGGTTTTATGGTTGCTTGTGTAATAAAGCATGTCCTTCGTATGTCACAGTTTGGGGCAACGGAAGTCTTTTAGTGATGGCTAATGGGTCTGGGCAGCATCCCTTCATGAATTTTTTTTTAATCCAATATCCGTTGA
TTTGATTGTGATTAGAGAACCTTGGACATTTTGCTGCTAAAGAAT

>CTNNBIP1_UBE4B_ENST00000400904_ENST00000343090_9970152_10238701 length=1667nt
Breakpoint=0nt
AGATCCTACAGTAAGGAATTGTTTGAAGAAGTTATTTCAAAGATGCGGAAGGCAGGGATCAAATCCACAATAGCAATAGAAAAATTTAAGCTGCTCGCCGAGAAAGTGGAGGAGATAGTGGCCAAGAACGCACGCGCAGAAATCGACTAC
AGCGACGCTCCTGATGAGTTCAGAGACCCTCTGATGGACACCCTCATGACAGACCCCGTGCGGCTGCCCTCTGGCACCATCATGGACCGCTCCATCATCCTGCGGCACCTGCTCAACTCCCCCACGGACCCCTTCAACCGGCAGACGCTG
ACAGAGAGCATGCTGGAACCAGTGCCAGAACTGAAAGAGCAGATTCAGGCGTGGATGAGAGAGAAACAGAACAGCGATCACTAAACCGTTCCGCCGCCCACCCTCTGCTAGACACAGCCAAGGCCAACGAGGCAAGCAGAAGCAGCGGCC
GCAGCGAAGCTGCCGTTCATGTGTTGGAGGCCAAATGTGGCAAACCAACCCCAGGCCCACCCAGAGCGAGCAAACGCTGAGACCTGAAAGGACATGGATGAGAAGAGGAGCCCGCTTCCTGTACATATATTTAAGTGACAAACACGGTCA
AAAGCTTAAGGGACAGGTTTTATGGTTGCTTGTGTAATAAAGCATGTCCTTCGTATGTCACAGTTTGGGGCAACGGAAGTCTTTTAGTGATGGCTAATGGGTCTGGGCAGCATCCCTTCATGAATTTTTTTTTAATCCAATATCCGTTGA
TTTGATTGTGATTAGAGAACCTTGGACATTTTGCTGCTAAAGAATCTTTTTTCCCCTCTCCCCCTTCCTGACCCTACTTGCACTGCTGTGGATTTTTTTAAGAGAAGCAAAAACAAAAGTAAACTCCTTTCCCTGGCCCTCCAAACATAT
ATTCTGTGAGATAACTGTGCCTGCTACCAAGTGTTAATCCTGGGATCGTATTTTTATATCATATTCACATATTTGTTTTTTTAATTGGTGTTAGATGACATGATTAATAAAAAAGGCAAGATATTTTCAGAATTTGAATTTCAGTTTTTT
TTTTCTTTTGAAATGTCCCTTTAAGATTTTTTTATTCTAAACAAAATAAAGAAAATCCTGCTGCTCTGGTCCTTGTGATAAGCCTCTCTTCGGCATCTGAGGAGCAGCTGCAGCAAAATCTAGGGGTGTAAGTGTATCAGGACTTATGTG
ACTTATATTTTGGGGAGATGAGGGTTGGGTTTTTTTTTTAATGCTACGTGACAGTTTGAAACCTTCACAGTTATCCTCTGGGGGTAAATCAATTCTTCAACCCTTGGGTGTGTGAGTTTGAGGCAGGGTCATTTGTGTGATGTGTTTGGC
CTTACCAAAGCAAAAGAGGGTGCAAGAATGTGGGAGTATGTCTGCCGGTTTCAACACACACAGACAAACACAGCCACACGCGCACACAAGTATAAGACTTTTTGTATTACTGCTCCCTACTTAACATACTTGAATTCTCAAATTTCCTTT
GGGGTAAAAAAAAAAAAAGGATTTGAAACCATAAAGTGTTCTGAAGAAATTAAGTCTATAAAAAGCATACTTTCTTTTTTCTTTTCCTTTTTTCCCTCCACAGACAATGTCCTCTGTTCAATTCCTAACGCAAACTACAATAAATGGTGA
CACACGTTCAGAAGAAA

>CTNNBIP1_UBE4B_ENST00000400904_ENST00000377157_9970152_10238701 length=1671nt
Breakpoint=0nt
AGATCCTACAGTAAGGAATTGTTTGAAGAAGTTATTTCAAAGATGCGGAAGGCAGGGATCAAATCCACAATAGCAATAGAAAAATTTAAGCTGCTCGCCGAGAAAGTGGAGGAGATAGTGGCCAAGAACGCACGCGCAGAAATCGACTAC
AGCGACGCTCCTGATGAGTTCAGAGGCAAGTGGACTCACCCTCTGATGGACACCCTCATGACAGACCCCGTGCGGCTGCCCTCTGGCACCATCATGGACCGCTCCATCATCCTGCGGCACCTGCTCAACTCCCCCACGGACCCCTTCAAC
CGGCAGACGCTGACAGAGAGCATGCTGGAACCAGTGCCAGAACTGAAAGAGCAGATTCAGGCGTGGATGAGAGAGAAACAGAACAGCGATCACTAAACCGTTCCGCCGCCCACCCTCTGCTAGACACAGCCAAGGCCAACGAGGCAAGCA
GAAGCAGCGGCCGCAGCGAAGCTGCCGTTCATGTGTTGGAGGCCAAATGTGGCAAACCAACCCCAGGCCCACCCAGAGCGAGCAAACGCTGAGACCTGAAAGGACATGGATGAGAAGAGGAGCCCGCTTCCTGTACATATATTTAAGTGA
CAAACACGGTCAAAAGCTTAAGGGACAGGTTTTATGGTTGCTTGTGTAATAAAGCATGTCCTTCGTATGTCACAGTTTGGGGCAACGGAAGTCTTTTAGTGATGGCTAATGGGTCTGGGCAGCATCCCTTCATGAATTTTTTTTTAATCC
AATATCCGTTGATTTGATTGTGATTAGAGAACCTTGGACATTTTGCTGCTAAAGAATCTTTTTTCCCCTCTCCCCCTTCCTGACCCTACTTGCACTGCTGTGGATTTTTTTAAGAGAAGCAAAAACAAAAGTAAACTCCTTTCCCTGGCC
CTCCAAACATATATTCTGTGAGATAACTGTGCCTGCTACCAAGTGTTAATCCTGGGATCGTATTTTTATATCATATTCACATATTTGTTTTTTTAATTGGTGTTAGATGACATGATTAATAAAAAAGGCAAGATATTTTCAGAATTTGAA
TTTCAGTTTTTTTTTTCTTTTGAAATGTCCCTTTAAGATTTTTTTATTCTAAACAAAATAAAGAAAATCCTGCTGCTCTGGTCCTTGTGATAAGCCTCTCTTCGGCATCTGAGGAGCAGCTGCAGCAAAATCTAGGGGTGTAAGTGTATC
AGGACTTATGTGACTTATATTTTGGGGAGATGAGGGTTGGGTTTTTTTTTTAATGCTACGTGACAGTTTGAAACCTTCACAGTTATCCTCTGGGGGTAAATCAATTCTTCAACCCTTGGGTGTGTGAGTTTGAGGCAGGGTCATTTGTGT
GATGTGTTTGGCCTTACCAAAGCAAAAGAGGGTGCAAGAATGTGGGAGTATGTCTGCCGGTTTCAACACACACAGACAAACACAGCCACACGCGCACACAAGTATAAGACTTTTTGTATTACTGCTCCCTACTTAACATACTTGAATTCT
CAAATTTCCTTTGGGGTAAAAAAAAAAAAAGGATTTGAAACCATAAAGTGTTCTGAAGAAATTAAGTCTATAAAAAGCATACTTTCTTTTTTCTTTTCCTTTTTTCCCTCCACAGACAATGTCCTCTGTTCAATTCCTAACGCAAACTAC
AATAAATGGTGACACACGTTC


check button C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for CTNNBIP1_UBE4B

check button In-frame Fusion Protein Sequences.

check button N-Truncated Protein (5UTR-3CDS) Sequences
>CTNNBIP1_UBE4B_ENST00000377263_ENST00000253251_9970152_10238701 length=122nt
MMNLRKSGTLGHPGSLDETTYERLAEETLDSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIWLSSPSRYVVDLSVMTGLGKTGCTPTTACPSMSCWPQSSLKP

>CTNNBIP1_UBE4B_ENST00000377263_ENST00000343090_9970152_10238701 length=184nt
MSLKYMYRKRAPLLIHVLSGLSVCSLWVGLGLVCHIWPPTHERQLRCGRCFCLPRWPWLCLAEGGRRNGLVIAVLFLSHPRLNLLFQFWHWFQHALCQRLPVEGVRGGVEQVPQDDGAVHDGARGQPHGVCHEGVHQRVSELIRSVAVVD
FCACVLGHYLLHFLGEQLKFFYCYCGFDPCLPHL

>CTNNBIP1_UBE4B_ENST00000377263_ENST00000377157_9970152_10238701 length=313nt
MFLQGKVLRLQRRHGRENMAAAIPASCCPQGWHIWAHTVSCSEALWWAAPIASVSVSVPFTAFQGTGHLGARATCRESGGTEVVDGQGAQPLGHGAFVPLGADDGGVDVLLLEGCDLSFLLRPVQRLMQPIVAKALVVLLEVHPLQDQAE
SGRLGHVHLLCAPAALQHALRGITLHNGHHQADHLPDLMHHEALALHPDHRKLQALPHKGFLAVHLQDVAAGTGILRPLLRGEIVEVVRALVAGQEPVDLLQRLGAQAVGLILNVPVLVRKGKRGQQVAIGPGITSVLGVKPARDPLQSQ
NPNVRGKVAVDLF

>CTNNBIP1_UBE4B_ENST00000400904_ENST00000253251_9970152_10238701 length=30nt
MQYINLGCNLITELSLGTFQAWHGMQFLHN

>CTNNBIP1_UBE4B_ENST00000400904_ENST00000343090_9970152_10238701 length=184nt
MSLKYMYRKRAPLLIHVLSGLSVCSLWVGLGLVCHIWPPTHERQLRCGRCFCLPRWPWLCLAEGGRRNGLVIAVLFLSHPRLNLLFQFWHWFQHALCQRLPVEGVRGGVEQVPQDDGAVHDGARGQPHGVCHEGVHQRVSELIRSVAVVD
FCACVLGHYLLHFLGEQLKFFYCYCGFDPCLPHL

>CTNNBIP1_UBE4B_ENST00000400904_ENST00000377157_9970152_10238701 length=313nt
MFLQGKVLRLQRRHGRENMAAAIPASCCPQGWHIWAHTVSCSEALWWAAPIASVSVSVPFTAFQGTGHLGARATCRESGGTEVVDGQGAQPLGHGAFVPLGADDGGVDVLLLEGCDLSFLLRPVQRLMQPIVAKALVVLLEVHPLQDQAE
SGRLGHVHLLCAPAALQHALRGITLHNGHHQADHLPDLMHHEALALHPDHRKLQALPHKGFLAVHLQDVAAGTGILRPLLRGEIVEVVRALVAGQEPVDLLQRLGAQAVGLILNVPVLVRKGKRGQQVAIGPGITSVLGVKPARDPLQSQ
NPNVRGKVAVDLF


check button C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for CTNNBIP1_UBE4B


check button TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences
NumGene GroupDomain LociFusion Protein IDFusion Gene NamePartnerMutated Residue in WT ProteinSeq. LengthMutated Residue in Fusion Protein

check button CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

NumGene GroupDomain LociFusion Protein IDFusion Gene NamePartnerMutated Residue in WT ProteinSeq. LengthMutated Residue in Fusion Protein

check button TCGA All Mutated Fusion Protein Sequences


Fusion Protein IDSample IDMutated PartnerAAchange in WTSeq. LengthAAchange in Fusion

check button CCLE All Mutated Fusion Protein Sequences


Fusion Protein IDSample IDMutated PartnerAAchange in WTSeq. LengthAAchange in Fusion

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Fusion Gene Exprssed Samples for CTNNBIP1_UBE4B


check buttonRNA-seq based fusion gene expressed samples.
SourceStudyDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDBLUSCTCGA-56-7730-01ACTNNBIP1

chr1

9970152-UBE4B

chr1

10238701

+
ChimerDBLUSCTCGA-56-7730-01ACTNNBIP1

chr1

9970152-UBE4B

chr1

9970152

+
ChimerDBLUSCTCGA-56-7730CTNNBIP1

chr1

9970152-UBE4B

chr1

9970152

+
WashULUSCTCGA-56-7730-01ACTNNBIP1

chr1

9970153-UBE4B

chr1

10238702

+
cBioPortalLUSC_TCGA_PAN_CAN_ATLAS_2018LUSCTCGA-56-7730-01CTNNBIP1

chr1

9910095UBE4B

chr1

10178644


check buttonDNA-seq based fusion gene expressed samples.
SourceStudyDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrandSV type
dbVarnstd100Unknown_CellUnknown_Set_9872007CTNNBIP1

chr1

9925714UBE4B

chr1

10147796

DEL
dbVarnstd100Unknown_CellUnknown_Set_9884031CTNNBIP1

chr1

9963962UBE4B

chr1

10118393

DUP
dbVarnstd113Unknown_CellUnknown_Set_49274CTNNBIP1

chr1

9925714UBE4B

chr1

10147796

DEL
dbVarnstd113Unknown_CellUnknown_Set_37250CTNNBIP1

chr1

9963962UBE4B

chr1

10118393

DUP
dbVarnstd223Unknown_CellCTNNBIP1

chr1

9961543UBE4B

chr1

10122905

DUP
dbVarnstd229Unknown_CellCTNNBIP1

chr1

9935487UBE4B

chr1

10100879

DUP
dbVarnstd229Unknown_CellCTNNBIP1

chr1

9961543UBE4B

chr1

10122905

DUP
dbVarnstd239Unknown_CellWG1004367-DNAD10-014941-0095503627CTNNBIP1

chr1

9926020UBE4B

chr1

10120793

DEL
dbVarnstd239Unknown_CellWG1004375-DNAG12-014403-0095501257CTNNBIP1

chr1

9926020UBE4B

chr1

10094313

DEL
dbVarnstd239Unknown_CellWG1004352-DNAF08-012752-0095437379CTNNBIP1

chr1

9942118UBE4B

chr1

10120793

DUP
dbVarnstd239Unknown_CellWG1004359-DNAG03-014543-0095436418CTNNBIP1

chr1

9942118UBE4B

chr1

10120793

DEL
dbVarnstd239Unknown_CellWG1006244-DNAH10-023883-1047564180CTNNBIP1

chr1

9942118UBE4B

chr1

10193026

DUP
dbVarnstd54Unknown_CellUnknown_Set_9884031CTNNBIP1

chr1

9963962UBE4B

chr1

10118393

DUP


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Related Drugs for CTNNBIP1_UBE4B


check button PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.
PMIDFusion Gene NameDrugStudy Title

check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status